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Tytuł :
Targeting the endothelin axis as a therapeutic strategy for oral cancer metastasis and pain.
Autorzy :
Dang D; Department of Oral and Maxillofacial Surgery, New York University, New York, NY, USA.; Bluestone Center for Clinical Research, New York University, New York, NY, USA.
Ye Y; Department of Oral and Maxillofacial Surgery, New York University, New York, NY, USA.; Bluestone Center for Clinical Research, New York University, New York, NY, USA.
Aouizerat BE; Department of Oral and Maxillofacial Surgery, New York University, New York, NY, USA.; Bluestone Center for Clinical Research, New York University, New York, NY, USA.; Rory Meyers College of Nursing, New York University, New York, NY, USA.
Patel YK; Bluestone Center for Clinical Research, New York University, New York, NY, USA.
Viet DT; Bluestone Center for Clinical Research, New York University, New York, NY, USA.
Chan KC; Division of Oral and Maxillofacial Radiology, Section of Hospital Dentistry, Columbia University Irving Medical Center, New York, NY, USA.
Ono K; Department of Physiology, Kyushu Dental University, Kitakyushu, Japan.
Doan C; Department of Oral and Maxillofacial Surgery, Loma Linda University School of Dentistry, Loma Linda, CA, USA.
Figueroa JD; Department of Basic Sciences, Center for Health Disparities and Molecular Medicine, Loma Linda University School of Medicine, Loma Linda, CA, USA.
Yu G; Rory Meyers College of Nursing, New York University, New York, NY, USA.
Viet CT; Department of Oral and Maxillofacial Surgery, Loma Linda University School of Dentistry, Loma Linda, CA, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 30; Vol. 10 (1), pp. 20832. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelins/*genetics
Mouth Neoplasms/*therapy
Neoplasm Metastasis/*therapy
Adult ; Animals ; Cell Line, Tumor ; Cell Proliferation/genetics ; Endothelins/metabolism ; Endothelins/physiology ; Female ; HeLa Cells ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mouth Neoplasms/metabolism ; Neoplasm Invasiveness/genetics ; Pain/metabolism ; Pain/physiopathology ; Pain Management/methods ; Pyrimidines/pharmacology ; Receptor, Endothelin A/genetics ; Receptor, Endothelin A/metabolism ; Receptor, Endothelin B/genetics ; Receptor, Endothelin B/metabolism ; Sulfonamides/pharmacology
Czasopismo naukowe
Tytuł :
Evolution of the endothelin pathway drove neural crest cell diversification.
Autorzy :
Square TA; Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO, USA. .; Department of Molecular and Cellular Biology, University of California, Berkeley, CA, USA. .
Jandzik D; Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO, USA. .; Department of Zoology, Comenius University in Bratislava, Bratislava, Slovakia. .; Department of Zoology, Charles University in Prague, Prague, Czech Republic. .
Massey JL; Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO, USA.
Romášek M; Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO, USA.; Gymnázium Jiřího Wolkera, Prostějov, Czech Republic.
Stein HP; Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO, USA.
Hansen AW; Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO, USA.
Purkayastha A; Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO, USA.
Cattell MV; Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO, USA.; Department of Biology, Metropolitan State University, Denver, CO, USA.
Medeiros DM; Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO, USA. .
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Źródło :
Nature [Nature] 2020 Sep; Vol. 585 (7826), pp. 563-568. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Evolution, Molecular*
Signal Transduction*
Endothelins/*metabolism
Neural Crest/*cytology
Petromyzon/*metabolism
Xenopus/*metabolism
Animals ; Bone Development ; Bone and Bones/cytology ; Bone and Bones/metabolism ; Cell Lineage ; Endothelins/genetics ; Female ; Head/growth & development ; Heart/growth & development ; Larva/growth & development ; Ligands ; Male ; Petromyzon/genetics ; Petromyzon/growth & development ; Receptors, Endothelin/deficiency ; Receptors, Endothelin/genetics ; Receptors, Endothelin/metabolism ; Xenopus/genetics ; Xenopus/growth & development
Czasopismo naukowe
Tytuł :
Sovateltide (IRL-1620) activates neuronal differentiation and prevents mitochondrial dysfunction in adult mammalian brains following stroke.
Autorzy :
Ranjan AK; Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, 60515, USA. .
Briyal S; Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, 60515, USA.
Gulati A; Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, 60515, USA. .; Pharmazz Inc. Research and Development, Willlowbrook, IL, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 29; Vol. 10 (1), pp. 12737. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelins/*administration & dosage
Infarction, Middle Cerebral Artery/*drug therapy
Mitochondria/*metabolism
Neural Stem Cells/*cytology
Peptide Fragments/*administration & dosage
Stroke/*drug therapy
Administration, Intravenous ; Animals ; Antigens, Nuclear/metabolism ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Differentiation/drug effects ; Cell Hypoxia/drug effects ; Disease Models, Animal ; Dynamins/metabolism ; Endothelins/pharmacology ; GTP Phosphohydrolases/metabolism ; Infarction, Middle Cerebral Artery/complications ; Infarction, Middle Cerebral Artery/metabolism ; Male ; Mitochondria/drug effects ; Mitochondrial Dynamics ; Mitochondrial Proteins/metabolism ; Nerve Tissue Proteins/metabolism ; Neural Stem Cells/drug effects ; Peptide Fragments/pharmacology ; Rats ; Stroke/etiology ; Stroke/metabolism
Czasopismo naukowe
Tytuł :
Endotheliitis, endothelin, and endothelin receptor blockers in COVID-19.
Autorzy :
Sanghavi DK; Department of Critical Care Medicine, Mayo Clinic, Jacksonville, FL, United States. Electronic address: .
Titus A; Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA, United States. Electronic address: .
Caulfield TR; Department of Neurologic Surgery, Mayo Clinic, Jacksonville, FL, United States.
David Freeman W; Department of Neurologic Surgery, Mayo Clinic, Jacksonville, FL, United States.
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Źródło :
Medical hypotheses [Med Hypotheses] 2021 May; Vol. 150, pp. 110564. Date of Electronic Publication: 2021 Mar 23.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*drug therapy
Endothelin Receptor Antagonists/*therapeutic use
Endothelium, Vascular/*pathology
Endothelins ; Humans ; Receptors, Endothelin ; Sulfonamides
Czasopismo naukowe
Tytuł :
Serum concentration of endocan, fetuin-A, and endothelin in plaque psoriasis - coincidence or fate? A preliminary study.
Autorzy :
Grochowiec, Marcelina
Narbutt, Joanna
Lesiak, Aleksandra
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Alternatywny tytuł :
Stężenia endokanu, fetuiny A i endoteliny w surowicy pacjentów z łuszczycą plackowatą - przypadek czy prawidłowość? Badanie wstępne.
Źródło :
Dermatology Review / Przeglad Dermatologiczny. 2021, Vol. 108 Issue 1, p16-26. 11p.
Czasopismo naukowe
Tytuł :
Inhibition of Endothelin system during the postnatal nephrogenic period in the rat. Its relationship with hypertension and renal disease in adulthood.
Autorzy :
Albertoni Borghese MF; Departamento de Ciencias Biológicas, Cátedra de Biología Celular y Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.; Departamento de Ciencias Biológicas, Cátedra de Biología Celular y Molecular, CONICET, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
Ortiz MDC; Departamento de Ciencias Biológicas, Cátedra de Biología Celular y Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
Marinoni RC; Departamento de Ciencias Biológicas, Cátedra de Biología Celular y Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
Oronel LH; Departamento de Ciencias Biológicas, Cátedra de Biología Celular y Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
Palamidessi M; Departamento de Ciencias Biológicas, Cátedra de Biología Celular y Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
Yarza CA; Departamento de Ciencias Biológicas, Cátedra de Biología Celular y Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
Di Siervi N; CONICET, Facultad de Farmacia y Bioquímica, Instituto de Investigaciones Farmacológicas (ININFA), Universidad de Buenos Aires, Buenos Aires, Argentina.
Davio C; Departamento de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.; CONICET, Facultad de Farmacia y Bioquímica, Instituto de Investigaciones Farmacológicas (ININFA), Universidad de Buenos Aires, Buenos Aires, Argentina.
Majowicz MP; Departamento de Ciencias Biológicas, Cátedra de Biología Celular y Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
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Źródło :
PloS one [PLoS One] 2020 Mar 03; Vol. 15 (3), pp. e0229756. Date of Electronic Publication: 2020 Mar 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelins/*metabolism
Hypertension/*etiology
Kidney Medulla/*growth & development
Receptors, Endothelin/*metabolism
Signal Transduction/*physiology
Adult ; Animals ; Animals, Newborn ; Aquaporin 2/metabolism ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Disease Models, Animal ; Endothelin Receptor Antagonists/pharmacology ; Endothelins/antagonists & inhibitors ; Epithelial Sodium Channels/metabolism ; Humans ; Hypertension/physiopathology ; Infant, Newborn ; Kidney Medulla/drug effects ; Male ; Rats ; Rats, Sprague-Dawley ; Renal Elimination/drug effects ; Renal Elimination/physiology ; Signal Transduction/drug effects ; Sodium Chloride, Dietary/adverse effects ; Sodium Chloride, Dietary/metabolism ; Vasopressins/metabolism
Czasopismo naukowe
Tytuł :
Endothelin: 30 Years From Discovery to Therapy.
Autorzy :
Barton M; From Molecular Internal Medicine, University of Zürich, Switzerland (M.B.).; Andreas Grüntzig Foundation, Zürich, Switzerland (M.B.).
Yanagisawa M; International Institute for Integrative Sleep Medicine (WPI-IIIS) and Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba, Japan (M.Y.).; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX (M.Y.).
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Źródło :
Hypertension (Dallas, Tex. : 1979) [Hypertension] 2019 Dec; Vol. 74 (6), pp. 1232-1265. Date of Electronic Publication: 2019 Nov 04.
Typ publikacji :
Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cardiovascular Diseases/*physiopathology
Endothelins/*biosynthesis
Endothelins/*history
Cardiovascular Diseases/drug therapy ; Clinical Trials as Topic ; Coronary Artery Disease/drug therapy ; Coronary Artery Disease/physiopathology ; Endothelins/drug effects ; Female ; Follow-Up Studies ; History, 20th Century ; Humans ; Hypertension/drug therapy ; Hypertension/physiopathology ; Male ; Receptors, Endothelin/drug effects ; Renal Artery Obstruction/drug therapy ; Renal Artery Obstruction/physiopathology ; Risk Assessment
Czasopismo naukowe
Tytuł :
Endothelins (EDN1, EDN2, EDN3) and their receptors (EDNRA, EDNRB, EDNRB2) in chickens: Functional analysis and tissue distribution.
Autorzy :
Liu H; Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, PR China.
Luo Q; Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, PR China.
Zhang J; Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, PR China.
Mo C; Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, PR China.
Wang Y; Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, PR China.
Li J; Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, PR China. Electronic address: .
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Źródło :
General and comparative endocrinology [Gen Comp Endocrinol] 2019 Nov 01; Vol. 283, pp. 113231. Date of Electronic Publication: 2019 Jul 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chickens/*metabolism
Endothelins/*metabolism
Receptors, Endothelin/*metabolism
Amino Acid Sequence ; Animals ; Endothelins/chemistry ; Endothelins/genetics ; Female ; HEK293 Cells ; Humans ; Male ; Receptors, Endothelin/chemistry ; Signal Transduction ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Endothelin receptors in the brain modulate autonomic responses and arrhythmogenesis during acute myocardial infarction in rats.
Autorzy :
Lekkas P; Cardiovascular Research Institute, Ioannina and Athens, Greece; Department of Physiology, Medical School, University of Ioannina, Greece.
Kontonika M; Cardiovascular Research Institute, Ioannina and Athens, Greece.
Georgiou ES; Cardiovascular Research Institute, Ioannina and Athens, Greece.
La Rocca V; Cardiovascular Research Institute, Ioannina and Athens, Greece.
Mouchtouri ET; Cardiovascular Research Institute, Ioannina and Athens, Greece; Department of Cardiology, Medical School, University of Ioannina, Greece.
Mourouzis I; Department of Pharmacology, Medical School, National & Kapodistrian University of Athens, Greece.
Pantos C; Department of Pharmacology, Medical School, National & Kapodistrian University of Athens, Greece.
Kolettis TM; Cardiovascular Research Institute, Ioannina and Athens, Greece; Department of Cardiology, Medical School, University of Ioannina, Greece. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2019 Dec 15; Vol. 239, pp. 117062. Date of Electronic Publication: 2019 Nov 14.
Typ publikacji :
Journal Article
MeSH Terms :
Endothelins/*pharmacology
Myocardial Infarction/*physiopathology
Receptors, Endothelin/*metabolism
Action Potentials/drug effects ; Animals ; Arrhythmias, Cardiac/complications ; Arrhythmias, Cardiac/metabolism ; Autonomic Nervous System/metabolism ; Brain/metabolism ; Brain/physiology ; Endothelin Receptor Antagonists/metabolism ; Endothelin Receptor Antagonists/pharmacology ; Endothelin-1/pharmacology ; Endothelins/metabolism ; Heart Rate/drug effects ; Heart Rate/physiology ; Male ; Myocardial Infarction/metabolism ; Myocardium/metabolism ; Rats ; Rats, Wistar ; Receptor, Endothelin A/metabolism ; Receptor, Endothelin B/metabolism ; Receptors, Endothelin/physiology ; Sympathetic Nervous System/drug effects ; Tachycardia, Ventricular/metabolism ; Tachycardia, Ventricular/physiopathology
Czasopismo naukowe
Tytuł :
Elucidating essential kinases of endothelin signalling by logic modelling of phosphoproteomics data.
Autorzy :
Schäfer A; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
Gjerga E; Faculty of Medicine, Joint Research Centre for Computational Biomedicine (JRC-COMBINE), RWTH Aachen University, Aachen, Germany.
Welford RW; Idorsia Pharmaceuticals, Allschwil, Switzerland.
Renz I; Idorsia Pharmaceuticals, Allschwil, Switzerland.
Lehembre F; Idorsia Pharmaceuticals, Allschwil, Switzerland.
Groenen PM; Idorsia Pharmaceuticals, Allschwil, Switzerland.
Saez-Rodriguez J; Faculty of Medicine, Joint Research Centre for Computational Biomedicine (JRC-COMBINE), RWTH Aachen University, Aachen, Germany.; Faculty of Medicine, Institute for Computational Biomedicine, Heidelberg University Hospital, Bioquant, Heidelberg University, Heidelberg, Germany.
Aebersold R; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.; Faculty of Science, University of Zürich, Zürich, Switzerland.
Gstaiger M; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.; Competence Center Personalized Medicine UZH/ETH, Zürich, Switzerland.
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Źródło :
Molecular systems biology [Mol Syst Biol] 2019 Aug; Vol. 15 (8), pp. e8828.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Protein Processing, Post-Translational*
Signal Transduction*
Endothelins/*pharmacology
Melanocytes/*metabolism
Phosphoproteins/*genetics
AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; Endothelins/genetics ; Endothelins/metabolism ; Gene Regulatory Networks ; Humans ; MAP Kinase Kinase 4/genetics ; MAP Kinase Kinase 4/metabolism ; Melanocytes/drug effects ; Melanocytes/pathology ; Phosphoproteins/metabolism ; Phosphorylation ; Protein Kinase C/genetics ; Protein Kinase C/metabolism ; Proteomics/methods ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, Endothelin B/genetics ; Receptor, Endothelin B/metabolism
Czasopismo naukowe
Tytuł :
Deletion of the myeloid endothelin-B receptor confers long-term protection from angiotensin II-mediated kidney, eye and vessel injury.
Autorzy :
Guyonnet L; Paris Cardiovascular Research Centre-PARCC, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Paris, Paris, France.
Czopek A; University/BHF Centre of Research Excellence, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK.
Farrah TE; University/BHF Centre of Research Excellence, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK.
Baudrie V; Paris Cardiovascular Research Centre-PARCC, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Paris, Paris, France.
Bonnin P; INSERM U1275 & Physiologie Clinique, Hôpital Lariboisière, Université de Paris, Paris, France.
Chipont A; Paris Cardiovascular Research Centre-PARCC, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Paris, Paris, France.
Lenoir O; Paris Cardiovascular Research Centre-PARCC, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Paris, Paris, France.
Sennlaub F; Institut National de la Santé et de la Recherche Médicale, Institut de la Vision, Paris, France.
Roubeix C; Institut National de la Santé et de la Recherche Médicale, Institut de la Vision, Paris, France.
Webb DJ; University/BHF Centre of Research Excellence, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK.
Kluth DC; University/BHF Centre of Research Excellence, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK.
Bailey MA; University/BHF Centre of Research Excellence, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK.
Tharaux PL; Paris Cardiovascular Research Centre-PARCC, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Paris, Paris, France. Electronic address: .
Dhaun N; Paris Cardiovascular Research Centre-PARCC, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Paris, Paris, France; University/BHF Centre of Research Excellence, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK. Electronic address: .
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Źródło :
Kidney international [Kidney Int] 2020 Nov; Vol. 98 (5), pp. 1193-1209. Date of Electronic Publication: 2020 Jun 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin II*
Hypertension*/chemically induced
Hypertension*/genetics
Animals ; Blood Pressure ; Endothelins ; Kidney ; Mice ; Receptor, Endothelin B/genetics
Czasopismo naukowe
Tytuł :
Central endothelin ET B receptor activation reduces blood pressure and catecholaminergic activity in the olfactory bulb of deoxycorticosterone acetate-salt hypertensive rats.
Autorzy :
Guil MJ; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Fisiología, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Buenos Aires, Argentina.
Soria C; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Fisiología, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Buenos Aires, Argentina.
Seijas M; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Fisiología, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Buenos Aires, Argentina.
Bianciotti LG; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Fisiopatología, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, Instituto de Inmunología, Genética y Metabolismo (INIGEM), Buenos Aires, Argentina.
Vatta MS; Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Fisiología, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Buenos Aires, Argentina. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 Oct 15; Vol. 885, pp. 173543. Date of Electronic Publication: 2020 Sep 05.
Typ publikacji :
Journal Article
MeSH Terms :
Blood Pressure/*drug effects
Hypertension/*drug therapy
Hypertension/*physiopathology
Olfactory Bulb/*drug effects
Receptor, Endothelin B/*agonists
Sympathetic Nervous System/*drug effects
Animals ; Desoxycorticosterone ; Endothelins/pharmacology ; Heart Rate/drug effects ; Hypertension/chemically induced ; Male ; Nitric Oxide Synthase Type I/biosynthesis ; Nitric Oxide Synthase Type I/genetics ; Peptide Fragments/pharmacology ; RNA, Messenger/biosynthesis ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Transition from post-capillary pulmonary hypertension to combined pre- and post-capillary pulmonary hypertension in swine: a key role for endothelin.
Autorzy :
van Duin RWB; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands.
Stam K; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands.
Cai Z; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands.
Uitterdijk A; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands.
Garcia-Alvarez A; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.; Hospital Clinic of Barcelona, IDIBAPS, Barcelona, Spain.
Ibanez B; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.; IIS-Fundación Jiménez Díaz University Hospital, Madrid, Spain.; CIBERCV, Madrid, Spain.
Danser AHJ; Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands.
Reiss IKM; Pediatrics / Neonatology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
Duncker DJ; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands.
Merkus D; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands.
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Źródło :
The Journal of physiology [J Physiol] 2019 Feb; Vol. 597 (4), pp. 1157-1173. Date of Electronic Publication: 2018 Jun 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelins/*metabolism
Hypertension, Pulmonary/*metabolism
Microvessels/*metabolism
Animals ; Down-Regulation ; Endothelins/genetics ; Endothelium, Vascular/metabolism ; Female ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/physiopathology ; Lung/blood supply ; Male ; Microvessels/drug effects ; Microvessels/physiopathology ; Pyridines/pharmacology ; Swine ; Tetrazoles/pharmacology ; Vasodilator Agents/pharmacology ; Ventricular Dysfunction, Left/complications
Czasopismo naukowe
Tytuł :
Effect of Ulinastatin Combined with Octreotide on Serum Endothelin, Endotoxin Levels and Immune Function in Acute Pancreatitis.
Autorzy :
Meng L; Department of Vascular Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University,Hangzhou City, Zhejiang Province, 310009, China.
Wu Z; Department of Vascular Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University,Hangzhou City, Zhejiang Province, 310009, China.
Zhang H; Department of Vascular Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University,Hangzhou City, Zhejiang Province, 310009, China.
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Źródło :
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP [J Coll Physicians Surg Pak] 2019 Jan; Vol. 29 (1), pp. 90-92.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Endothelins/*blood
Endotoxins/*blood
Gastrointestinal Agents/*pharmacology
Glycoproteins/*pharmacology
Immunoglobulins/*blood
Octreotide/*pharmacology
Pancreatitis/*drug therapy
Trypsin Inhibitors/*pharmacology
Acute Disease ; Adult ; Drug Combinations ; Endothelins/drug effects ; Female ; Gastrointestinal Agents/administration & dosage ; Glycoproteins/administration & dosage ; Humans ; Immunoglobulins/drug effects ; Male ; Middle Aged ; Octreotide/administration & dosage ; Pancreatitis/metabolism ; Treatment Outcome ; Trypsin Inhibitors/administration & dosage
Czasopismo naukowe
Tytuł :
The EDN2 rs110287192 gene polymorphism is associated with paratuberculosis susceptibility in multibreed cattle population.
Autorzy :
Çınar MU; Department of Animal Science, Faculty of Agriculture, Erciyes University, Kayseri, Turkey.; Department of Veterinary Microbiology & Pathology, Washington State University, Pullman, WA, United States of America.
Akyüz B; Department of Genetics, Faculty of Veterinary Medicine, Erciyes University, Kayseri, Turkey.
Arslan K; Department of Genetics, Faculty of Veterinary Medicine, Erciyes University, Kayseri, Turkey.
White SN; Department of Veterinary Microbiology & Pathology, Washington State University, Pullman, WA, United States of America.; Animal Disease Research Unit, Agricultural Research Service, U.S. Department of Agriculture, Pullman, WA, United States of America.; Center for Reproductive Biology, Washington State University, Pullman, WA, United States of America.
Neibergs HL; Center for Reproductive Biology, Washington State University, Pullman, WA, United States of America.; Department of Animal Science, Washington State University, Pullman, WA, United States of America.
Gümüşsoy KS; Department of Microbiology, Erciyes University, Faculty of Veterinary Medicine, Kayseri, Turkey.
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Źródło :
PloS one [PLoS One] 2020 Sep 03; Vol. 15 (9), pp. e0238631. Date of Electronic Publication: 2020 Sep 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breeding*
Genetic Predisposition to Disease*
Cattle/*genetics
Cattle/*microbiology
Endothelins/*genetics
Paratuberculosis/*genetics
Polymorphism, Single Nucleotide/*genetics
Alleles ; Animals ; Logistic Models ; Paratuberculosis/microbiology
Czasopismo naukowe
Tytuł :
First trimester inflammatory mediators in women with chronic hypertension.
Autorzy :
Nzelu D; Fetal Medicine Research Institute, King's College Hospital, London, UK.
Dumitrascu-Biris D; Fetal Medicine Research Institute, King's College Hospital, London, UK.
Karampitsakos T; Fetal Medicine Research Institute, King's College Hospital, London, UK.
Nicolaides KK; Fetal Medicine Research Institute, King's College Hospital, London, UK.; King's College London, London, UK.
Kametas NA; Fetal Medicine Research Institute, King's College Hospital, London, UK.; King's College London, London, UK.
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Źródło :
Acta obstetricia et gynecologica Scandinavica [Acta Obstet Gynecol Scand] 2020 Sep; Vol. 99 (9), pp. 1198-1205. Date of Electronic Publication: 2020 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelins/*blood
Hypertension/*blood
Inflammation Mediators/*blood
Interleukin-6/*blood
Pregnancy Trimester, First/*blood
Tumor Necrosis Factor-alpha/*blood
Vascular Cell Adhesion Molecule-1/*blood
Adult ; Biomarkers/blood ; Case-Control Studies ; Female ; Gestational Age ; Humans ; Pre-Eclampsia/blood ; Pregnancy
Czasopismo naukowe

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