Temat: "ENZYME inhibitors" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Clinical impact of suboptimal RAASi therapy following an episode of hyperkalemia.
Autorzy:: Kanda E; Department of Medical Science, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan. .
Rastogi A; Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA.
Murohara T; Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Lesén E; Medical & Payer Evidence, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Agiro A; US Evidence, Medical Affairs, BioPharmaceuticals R&D, AstraZeneca, DE, Wilmington, USA.
Arnold M; Real World Science and Digital, AstraZeneca, Cambridge, UK.
Chen G; Health Economics & Payer Evidence, AstraZeneca, Cambridge, UK.
Yajima T; CVRM TA, Medical Affairs, AstraZeneca, Tokyo, Japan.
Järbrink K; Medical & Payer Evidence, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Pollack CV Jr; Department of Emergency Medicine, University of Mississippi School of Medicine, Jackson, MS, USA.; Pokaż więcej
Źródło:: BMC nephrology [BMC Nephrol] 2023 Jan 19; Vol. 24 (1), pp. 18. Date of Electronic Publication: 2023 Jan 19.
Typ publikacji:: Observational Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Angiotensin-Converting Enzyme Inhibitors*/adverse effects
Heart Failure*/complications
Heart Failure*/drug therapy
Hyperkalemia*/chemically induced
Hyperkalemia*/drug therapy
Renal Insufficiency, Chronic*/complications
Renal Insufficiency, Chronic*/drug therapy
Humans ; Aldosterone ; Antihypertensive Agents/therapeutic use ; Enzyme Inhibitors/therapeutic use ; Potassium/therapeutic use ; Renin-Angiotensin System

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Skocz do pozycji: 2.

Tytuł:: Discovery of novel sulfonamide chromone-oxime derivatives as potent indoleamine 2,3-dioxygenase 1 inhibitors.
Autorzy:: Wang K; Guangxi Key Laboratory for Pharmaceutical Molecular Discovery and Druggability Optimization, School of Pharmacy, Guilin Medical University, Guilin, 541199, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin, 541199, China.
Song LH; Guangxi Key Laboratory for Pharmaceutical Molecular Discovery and Druggability Optimization, School of Pharmacy, Guilin Medical University, Guilin, 541199, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin, 541199, China.
Liang QL; Guangxi Key Laboratory for Pharmaceutical Molecular Discovery and Druggability Optimization, School of Pharmacy, Guilin Medical University, Guilin, 541199, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin, 541199, China.
Zhang Y; Guangxi Key Laboratory for Pharmaceutical Molecular Discovery and Druggability Optimization, School of Pharmacy, Guilin Medical University, Guilin, 541199, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin, 541199, China.
Ma XL; Guangxi Key Laboratory for Pharmaceutical Molecular Discovery and Druggability Optimization, School of Pharmacy, Guilin Medical University, Guilin, 541199, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin, 541199, China.
Wang Q; Guangxi Key Laboratory for Pharmaceutical Molecular Discovery and Druggability Optimization, School of Pharmacy, Guilin Medical University, Guilin, 541199, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin, 541199, China.
Zhang HY; Guangxi Key Laboratory for Pharmaceutical Molecular Discovery and Druggability Optimization, School of Pharmacy, Guilin Medical University, Guilin, 541199, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin, 541199, China.
Jiang CN; Guangxi Key Laboratory for Pharmaceutical Molecular Discovery and Druggability Optimization, School of Pharmacy, Guilin Medical University, Guilin, 541199, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin, 541199, China. Electronic address: .
Wei JH; Guangxi Key Laboratory for Pharmaceutical Molecular Discovery and Druggability Optimization, School of Pharmacy, Guilin Medical University, Guilin, 541199, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin, 541199, China. Electronic address: .
Huang RZ; Guangxi Key Laboratory for Pharmaceutical Molecular Discovery and Druggability Optimization, School of Pharmacy, Guilin Medical University, Guilin, 541199, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin, 541199, China. Electronic address: .; Pokaż więcej
Źródło:: European journal of medicinal chemistry [Eur J Med Chem] 2023 Jun 05; Vol. 254, pp. 115349. Date of Electronic Publication: 2023 Apr 11.
Typ publikacji:: Journal Article
MeSH Terms:: Indoleamine-Pyrrole 2,3,-Dioxygenase*
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/chemistry
Animals ; Mice ; Structure-Activity Relationship ; Molecular Docking Simulation ; Oximes/pharmacology ; Heme ; Sulfonamides/pharmacology

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Skocz do pozycji: 3.

Tytuł:: Monobody Inhibitor Selective to the Phosphatase Domain of SHP2 and its Use as a Probe for Quantifying SHP2 Allosteric Regulation.
Autorzy:: Sha F; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, United States.
Kurosawa K; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, United States; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, United States.
Glasser E; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, United States.
Ketavarapu G; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, United States.
Albazzaz S; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, United States.
Koide A; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, United States; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, United States; Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, United States.
Koide S; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, United States; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, United States; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, United States. Electronic address: .; Pokaż więcej
Źródło:: Journal of molecular biology [J Mol Biol] 2023 Apr 15; Vol. 435 (8), pp. 168010. Date of Electronic Publication: 2023 Feb 16.
Typ publikacji:: Journal Article
MeSH Terms:: Protein Tyrosine Phosphatase, Non-Receptor Type 11*/antagonists & inhibitors
Protein Tyrosine Phosphatase, Non-Receptor Type 11*/chemistry
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Humans ; Allosteric Regulation/drug effects ; Mutation ; Neoplasms/genetics ; Signal Transduction ; Protein Domains

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Skocz do pozycji: 4.

Tytuł:: In Vitro and In Silico Studies on Angiotensin I-Converting Enzyme Inhibitory Peptides Found in Hydrophobic Domains of Porcine Elastin.
Autorzy:: Hatakenaka T; Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, Japan.; Vital Resources Applied Laboratory, Inc., Iizuka 820-0067, Japan.
Kato T; Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, Japan.
Okamoto K; Vital Resources Applied Laboratory, Inc., Iizuka 820-0067, Japan.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Apr 10; Vol. 28 (8). Date of Electronic Publication: 2023 Apr 10.
Typ publikacji:: Journal Article
MeSH Terms:: Angiotensin-Converting Enzyme Inhibitors*/pharmacology
Angiotensin-Converting Enzyme Inhibitors*/chemistry
Peptidyl-Dipeptidase A*/chemistry
Animals ; Swine ; Molecular Docking Simulation ; Elastin ; Peptides/pharmacology ; Peptides/chemistry

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Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 5.

Tytuł:: Chemical Characterization and Multidirectional Biological Effects of Different Solvent Extracts of Arum elongatum: in Vitro and in Silico Approaches.
Autorzy:: Fawzi Mahomoodally M; Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Reduit, 80837, Mauritius.; Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Chennai, 600077, India.; Center of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.
Zengin G; Department of Biology, Faculty of Science, Selcuk University, Selcuklu, 42130, Konya, Turkey.
Roumita SS; Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Reduit, 80837, Mauritius.
Caprioli G; School of Pharmacy, University of Camerino, 62032, Camerino, Italy.
Mustafa AM; School of Pharmacy, University of Camerino, 62032, Camerino, Italy.
Piatti D; School of Pharmacy, University of Camerino, 62032, Camerino, Italy.
Yıldıztugay E; Department of Biotechnology, Faculty of Science, Selcuk University, Selcuklu, 42130, Konya, Turkey.
Ak G; Department of Biology, Faculty of Science, Selcuk University, Selcuklu, 42130, Konya, Turkey.
Esra Karadağ A; Department of Pharmacognosy, School of Pharmacy, Istanbul Medipol University, 34810, Istanbul, Türkiye.
Khalid A; Substance Abuse and Toxicology Research Center, Jazan University, P.O. Box: 114, Jazan, 45142, Saudi Arabia.; Medicinal and Aromatic Plants and Traditional Medicine Research Institute, National Center for Research, 2404, Khartoum, Sudan.
Abdalla AN; Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, 21955, Saudi Arabia.
Ibrahim Uba A; Department of Molecular Biology and Genetics, Istanbul AREL University, 34537, Istanbul, Türkiye.
Demirci F; Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470, Eskisehir, Türkiye.; Pokaż więcej
Źródło:: Chemistry & biodiversity [Chem Biodivers] 2023 Apr; Vol. 20 (4), pp. e202201181. Date of Electronic Publication: 2023 Mar 22.
Typ publikacji:: Journal Article
MeSH Terms:: Arum*/chemistry
Enzyme Inhibitors*/chemistry
Plant Extracts*/pharmacology
Plant Extracts*/chemistry
Acetylcholinesterase ; Antioxidants/chemistry ; Butyrylcholinesterase ; Caffeic Acids ; Flavonoids/pharmacology ; Flavonoids/analysis ; Kaempferols ; Methanol ; Monophenol Monooxygenase ; Parabens ; Solvents ; Water ; Ellagic Acid/chemistry ; Ellagic Acid/pharmacology

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Skocz do pozycji: 6.

Tytuł:: Relationship Between Phenolic Content Determined by LC/MS/MS and Antioxidant Capacity and Enzyme Inhibition of Cyclotrichium niveum L.
Autorzy:: Güzel A; Vocational School of Health Services, Inonu University, Malatya, 44000, Turkey.; Pokaż więcej
Źródło:: Chemistry & biodiversity [Chem Biodivers] 2023 Apr; Vol. 20 (4), pp. e202300027. Date of Electronic Publication: 2023 Mar 20.
Typ publikacji:: Journal Article
MeSH Terms:: Antioxidants*/chemistry
Lamiaceae*/chemistry
Lamiaceae*/enzymology
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
Humans ; Acetylcholinesterase ; Methanol ; Phenols/chemistry ; Phytochemicals ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Tandem Mass Spectrometry ; Water

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Skocz do pozycji: 7.

Tytuł:: Angiotensin pathways under therapy with empagliflozin in patients with chronic heart failure.
Autorzy:: Bosch A; Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Poglitsch M; Attoquant Diagnostics, Vienna, Austria.
Kannenkeril D; Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Kolwelter J; Department of Cardiology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Striepe K; Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Ott C; Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.; Department of Nephrology and Hypertension, Paracelsus Medical University, Nürnberg, Germany.
Rauh M; Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Schiffer M; Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Achenbach S; Department of Cardiology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Schmieder RE; Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.; Pokaż więcej
Źródło:: ESC heart failure [ESC Heart Fail] 2023 Jun; Vol. 10 (3), pp. 1635-1642. Date of Electronic Publication: 2023 Feb 13.
Typ publikacji:: Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Angiotensin-Converting Enzyme Inhibitors*/therapeutic use
Heart Failure*/drug therapy
Humans ; Angiotensin II ; Angiotensin Receptor Antagonists/therapeutic use ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Receptors, Angiotensin ; Sodium

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Skocz do pozycji: 8.

Tytuł:: Synthesis and biological evaluation of new kojic acid-1,3,4-oxadiazole hybrids as tyrosinase inhibitors and their application in the anti-browning of fresh-cut mushrooms.
Autorzy:: Wang G; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, China. Electronic address: .
He M; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, China; Teaching and Research Section of Natural Medicinal Chemistry, School of Pharmacy, Guizhou Medical University, Guiyang, China.
Huang Y; Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Medical University, Guiyang, China.
Peng Z; Clinical Trails Center, The Affiliated Hospital of Guizhou Medical University, Guiyang, China. Electronic address: .; Pokaż więcej
Źródło:: Food chemistry [Food Chem] 2023 May 30; Vol. 409, pp. 135275. Date of Electronic Publication: 2022 Dec 22.
Typ publikacji:: Journal Article
MeSH Terms:: Enzyme Inhibitors*/chemistry
Agaricales*/metabolism
Molecular Docking Simulation ; Copper ; Monophenol Monooxygenase ; Structure-Activity Relationship ; Molecular Structure

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Skocz do pozycji: 9.

Tytuł:: Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors.
Autorzy:: Skácel J; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.
Djukic S; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.
Baszczyňski O; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.; Faculty of Science, Charles University in Prague, Hlavova 2030/8, Prague 2 12843, Czech Republic.
Kalčic F; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.
Bílek T; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.
Chalupský K; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.
Kozák J; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.
Dvořáková A; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.
Tloušt'ová E; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.
Král'ová Z; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.; Faculty of Science, Charles University in Prague, Hlavova 2030/8, Prague 2 12843, Czech Republic.
Šmídková M; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.
Voldřich J; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.; University of Chemistry and Technology, Technická 5, Prague 16628, Czech Republic.
Rumlová M; University of Chemistry and Technology, Technická 5, Prague 16628, Czech Republic.
Pachl P; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.
Brynda J; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.
Vučková T; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.
Fábry M; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.; Institute of Molecular Genetics, The Czech Academy of Science, Vídeňská 1083, Prague 14220, Czech Republic.
Snášel J; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.
Pichová I; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.
Řezáčová P; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.
Mertlíková-Kaiserová H; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.
Janeba Z; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Flemingovo nám. 2, Prague 16610, Czech Republic.; Pokaż więcej
Źródło:: Journal of medicinal chemistry [J Med Chem] 2023 May 25; Vol. 66 (10), pp. 6652-6681. Date of Electronic Publication: 2023 May 03.
Typ publikacji:: Journal Article
MeSH Terms:: Purine-Nucleoside Phosphorylase*/metabolism
Enzyme Inhibitors*/chemistry
Humans ; Crystallography

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Skocz do pozycji: 10.

Tytuł:: Purification, Identification, and Inhibitory Mechanisms of a Novel ACE Inhibitory Peptide from Torreya grandis .
Autorzy:: Wu F; College of Advanced Agricultural Sciences, Zhejiang Agriculture and Forestry University, Hangzhou 311300, China.
Luo X; College of Food and Health, Zhejiang Agriculture and Forestry University, Hangzhou 311300, China.
Zhang Y; College of Food and Health, Zhejiang Agriculture and Forestry University, Hangzhou 311300, China.
Wang P; College of Food and Health, Zhejiang Agriculture and Forestry University, Hangzhou 311300, China.
Chang Y; College of Food and Health, Zhejiang Agriculture and Forestry University, Hangzhou 311300, China.
He Z; College of Food and Health, Zhejiang Agriculture and Forestry University, Hangzhou 311300, China.
Liu X; College of Food and Health, Zhejiang Agriculture and Forestry University, Hangzhou 311300, China.; Pokaż więcej
Źródło:: Nutrients [Nutrients] 2023 May 18; Vol. 15 (10). Date of Electronic Publication: 2023 May 18.
Typ publikacji:: Journal Article
MeSH Terms:: Antihypertensive Agents*/pharmacology
Antihypertensive Agents*/chemistry
Angiotensin-Converting Enzyme Inhibitors*/metabolism
Humans ; Molecular Docking Simulation ; Chromatography, Liquid ; Endothelial Cells/metabolism ; Tandem Mass Spectrometry ; Peptides/chemistry ; Peptidyl-Dipeptidase A/metabolism ; Protein Hydrolysates/metabolism

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Skocz do pozycji: 11.

Tytuł:: Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1.
Autorzy:: Markwalder JA; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States. Electronic address: .
Balog AJ; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.
Williams DK; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States. Electronic address: .
Nara SJ; Discovery Chemistry, Biocon Bristol Myers Squibb Research & Development Center, Bangalore, India.
Reddy R; Discovery Chemistry, Biocon Bristol Myers Squibb Research & Development Center, Bangalore, India.
Roy S; Former Bristol Myers Squibb Employee, United States.
Kanyaboina Y; Discovery Chemistry, Biocon Bristol Myers Squibb Research & Development Center, Bangalore, India.
Li X; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.
Johnston K; Former Bristol Myers Squibb Employee, United States.
Fan Y; Former Bristol Myers Squibb Employee, United States.
Lewis H; Former Bristol Myers Squibb Employee, United States.
Marsilio F; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.
Yan C; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.
Critton D; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.
Newitt JA; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.
Traeger SC; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.
Wu DR; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.
Jure-Kunkel MN; Former Bristol Myers Squibb Employee, United States.
Jayaraman L; Former Bristol Myers Squibb Employee, United States.
Lin TA; Former Bristol Myers Squibb Employee, United States.
Sinz MW; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ 08543, United States.
Hunt JT; Former Bristol Myers Squibb Employee, United States.
Seitz SP; Former Bristol Myers Squibb Employee, United States.; Pokaż więcej
Źródło:: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 May 15; Vol. 88, pp. 129280. Date of Electronic Publication: 2023 Apr 11.
Typ publikacji:: Journal Article
MeSH Terms:: Enzyme Inhibitors*/chemistry
Ethers*
Humans ; Structure-Activity Relationship ; HeLa Cells ; Indoleamine-Pyrrole 2,3,-Dioxygenase

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Skocz do pozycji: 12.

Tytuł:: Study on the Effect of EZH2 Inhibitor Combined with TIGIT Monoclonal Antibody against Multiple Myeloma Cells.
Autorzy:: Liu Z; Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan Street, Heping District, Tianjin 300052, China.
Jia Y; Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan Street, Heping District, Tianjin 300052, China.
Yang C; Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan Street, Heping District, Tianjin 300052, China.
Liu H; Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan Street, Heping District, Tianjin 300052, China.
Shen H; Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan Street, Heping District, Tianjin 300052, China.
Wang H; Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan Street, Heping District, Tianjin 300052, China.
Fu R; Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan Street, Heping District, Tianjin 300052, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 May 11; Vol. 24 (10). Date of Electronic Publication: 2023 May 11.
Typ publikacji:: Journal Article
MeSH Terms:: Antibodies, Monoclonal*/therapeutic use
Enhancer of Zeste Homolog 2 Protein*/antagonists & inhibitors
Enzyme Inhibitors*/therapeutic use
Multiple Myeloma*/metabolism
Humans ; Histones/metabolism ; Receptors, Immunologic/metabolism

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Skocz do pozycji: 13.

Tytuł:: Using Machine Learning and Molecular Docking to Leverage Urease Inhibition Data for Virtual Screening.
Autorzy:: Aniceto N; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.; Department of Pharmaceutical Sciences and Medicines, Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.
Albuquerque TS; iBB-Institute for Bioengineering and Biosciences, and Associate Laboratory i4HB-Institute for Health and Bioeconomy at Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
Bonifácio VDB; iBB-Institute for Bioengineering and Biosciences, and Associate Laboratory i4HB-Institute for Health and Bioeconomy at Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.; Bioengineering Department, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
Guedes RC; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.; Department of Pharmaceutical Sciences and Medicines, Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal.
Martinho N; iBB-Institute for Bioengineering and Biosciences, and Associate Laboratory i4HB-Institute for Health and Bioeconomy at Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 May 03; Vol. 24 (9). Date of Electronic Publication: 2023 May 03.
Typ publikacji:: Journal Article
MeSH Terms:: Urease*/metabolism
Enzyme Inhibitors*/chemistry
Molecular Docking Simulation ; Computer Simulation ; Urea

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Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 14.

Tytuł:: Effect of multi-mode sweep frequency ultrasound pretreatment on properties of the zeins and ACE inhibitory peptides activity of the hydrolysates.
Autorzy:: Zhang S; College of Food Science and Engineering, Qingdao Agricultural University, Qingdao, China.
Xu Z; College of Food Science and Engineering, Qingdao Agricultural University, Qingdao, China.
Zheng W; College of Food Science and Engineering, Qingdao Agricultural University, Qingdao, China.
Pan Q; College of Food Science and Engineering, Qingdao Agricultural University, Qingdao, China. Electronic address: .
Zhu Y; College of Food Science and Engineering, Qingdao Agricultural University, Qingdao, China. Electronic address: .; Pokaż więcej
Źródło:: Food chemistry [Food Chem] 2023 May 01; Vol. 407, pp. 135126. Date of Electronic Publication: 2022 Dec 01.
Typ publikacji:: Journal Article
MeSH Terms:: Angiotensin-Converting Enzyme Inhibitors*/chemistry
Zein*/metabolism
Peptides/chemistry ; Hydrolysis ; Proteolysis ; Protein Hydrolysates/chemistry

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Skocz do pozycji: 15.

Tytuł:: Understanding the Chemical Composition and Biological Activities of Different Extracts of Secamone afzelii Leaves: A Potential Source of Bioactive Compounds for the Food Industry.
Autorzy:: Sinan KI; Department of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey.
Yagi S; Department of Botany, Faculty of Science, University of Khartoum, Khartoum 11115, Sudan.
Llorent-Martínez EJ; Department of Physical and Analytical Chemistry, University of Jaén, Campus Las Lagunillas S/N, 23071 Jaén, Spain.
Ruiz-Medina A; Department of Physical and Analytical Chemistry, University of Jaén, Campus Las Lagunillas S/N, 23071 Jaén, Spain.
Gordo-Moreno AI; Department of Physical and Analytical Chemistry, University of Jaén, Campus Las Lagunillas S/N, 23071 Jaén, Spain.
Stefanucci A; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.
Mollica A; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.
Bene K; Laboratoire de Botanique et Phytothérapie, Unité de Formation et de Recherche Sciences de la Nature, Université Nangui Abrogoua, Abidjan 02 BP 801, Côte d'Ivoire.
Zengin G; Department of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Apr 24; Vol. 28 (9). Date of Electronic Publication: 2023 Apr 24.
Typ publikacji:: Journal Article
MeSH Terms:: Enzyme Inhibitors*/pharmacology
Antioxidants*/chemistry
Methanol/chemistry ; Monophenol Monooxygenase ; Plant Extracts/chemistry ; Butyrylcholinesterase ; Plant Leaves/chemistry ; Flavonoids/pharmacology ; Flavonoids/analysis ; Phenols/analysis ; Food Industry ; Water/analysis

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Skocz do pozycji: 16.

Tytuł:: Au-Fe 3 O 4 nanozyme coupled with CRISPR-Cas12a for sensitive and visual antibiotic resistance diagnosing.
Autorzy:: Chen H; Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University, Xiamen, 361005, PR China.
Li B; School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, PR China.
Shi S; State Key Laboratory of Computer Architecture, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, 100190, PR China; School of Computer Science and Technology, University of Chinese Academy of Sciences, Beijing, 100049, PR China.
Zhou T; Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University, Xiamen, 361005, PR China.
Wang X; School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, PR China.
Wang Z; College of Materials Science and Engineering, Hunan University, Changsha, 410072, PR China.
Zhou X; Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University, Xiamen, 361005, PR China.
Wang M; Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University, Xiamen, 361005, PR China.
Shi W; Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University, Xiamen, 361005, PR China. Electronic address: .
Ren L; Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University, Xiamen, 361005, PR China; State Key Lab of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, 361005, PR China. Electronic address: .; Pokaż więcej
Źródło:: Analytica chimica acta [Anal Chim Acta] 2023 Apr 22; Vol. 1251, pp. 341014. Date of Electronic Publication: 2023 Feb 25.
Typ publikacji:: Journal Article
MeSH Terms:: Angiotensin Receptor Antagonists*
Angiotensin-Converting Enzyme Inhibitors*
CRISPR-Cas Systems ; Ampicillin ; Drug Resistance, Microbial/genetics

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Szczegóły

Skocz do pozycji: 17.

Tytuł:: Dihydropyrimidone Derivatives as Thymidine Phosphorylase Inhibitors: Inhibition Kinetics, Cytotoxicity, and Molecular Docking.
Autorzy:: Cui TM; School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
Altaf M; Department of Biochemistry, Federal Urdu University of Arts, Sciences and Technology, Karachi 75300, Pakistan.
Aldarhami A; Department of Medical Microbiology, Qunfudah Faculty of Medicine, Umm Al-Qura University, Al-Qunfudah 21961, Saudi Arabia.
Bazaid AS; Department of Medical Laboratory Science, College of Applied Medical Sciences, University of Ha'il, Hail 55476, Saudi Arabia.
Saeedi NH; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.
Alkayyal AA; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.
Alshabrmi FM; Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.
Ali F; Department of Chemistry, Federal Urdu University of Arts, Sciences and Technology, Karachi 75300, Pakistan.
Aladhadh M; Department of Food Science and Human Nutrition, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah 51452, Saudi Arabia.
Khan MY; Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Vaccine and Immunotherapy Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Alsaiari AA; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.
Ma YR; School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Apr 21; Vol. 28 (8). Date of Electronic Publication: 2023 Apr 21.
Typ publikacji:: Journal Article
MeSH Terms:: Thymidine Phosphorylase*
Enzyme Inhibitors*/pharmacology
Animals ; Mice ; Molecular Docking Simulation ; Drug Discovery

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Skocz do pozycji: 18.

Tytuł:: Dynamic interfacial properties and foam behavior of licorice root extract solutions.
Autorzy:: Tighchi HA; Faculty of Mechanical Engineering, Shahrood University of Technology, Shahrood, Iran.
Kayhani MH; Faculty of Mechanical Engineering, Shahrood University of Technology, Shahrood, Iran. Electronic address: h_.
Faezian A; Department of Food Machinery Design, Research Institute of Food Science & Technology (RIFST), Mashhad, Iran.
Yeganehzad S; Department of Food Processing, Research Institute of Food Science & Technology (RIFST), Mashhad, Iran.
Miller R; Technical University Darmstadt, Physics Department, Germany.; Pokaż więcej
Źródło:: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2023 Apr; Vol. 224, pp. 113181. Date of Electronic Publication: 2023 Jan 30.
Typ publikacji:: Journal Article
MeSH Terms:: Surface-Active Agents*
Enzyme Inhibitors*
Surface Properties ; Surface Tension ; Rheology ; Adsorption ; Water

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Szczegóły

Skocz do pozycji: 19.

Tytuł:: Anchoring of Polymer Loops on Enzyme-Immobilized Mesoporous ZIF-8 Enhances the Recognition Selectivity of Angiotensin-Converting Enzyme Inhibitory Peptides.
Autorzy:: Wang Z; School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.; Institute of Biological Manufacturing Technology Co., Ltd., Guangxi Institute of Industrial Technology, Nanning 530002, China.
Zhou Q; School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
Liu S; Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning 530006, China.
Liao D; School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
Liu P; Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning 530006, China.; Key Laboratory of New Technology for Chemical and Biological Transformation Process of Guangxi Higher Education Institutes, Guangxi Minzu University, Nanning 530006, China.
Lan X; Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning 530006, China.; Key Laboratory of New Technology for Chemical and Biological Transformation Process of Guangxi Higher Education Institutes, Guangxi Minzu University, Nanning 530006, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Mar 31; Vol. 28 (7). Date of Electronic Publication: 2023 Mar 31.
Typ publikacji:: Journal Article
MeSH Terms:: Peptides*/pharmacology
Peptides*/chemistry
Angiotensin-Converting Enzyme Inhibitors*/pharmacology
Angiotensin-Converting Enzyme Inhibitors*/chemistry
Antihypertensive Agents/chemistry ; Peptidyl-Dipeptidase A ; Angiotensins

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Skocz do pozycji: 20.

Tytuł:: Enzymes and Enzyme Inhibitors-Applications in Medicine and Diagnosis.
Autorzy:: Geronikaki A; School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Eleutheriou PT; Clinical Chemistry-Biochemistry, International Hellenic University, 57400 Thessalonik, Greece.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 09; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 09.
Typ publikacji:: Editorial
MeSH Terms:: Enzyme Inhibitors*/therapeutic use
Enzyme Inhibitors*/pharmacology
Medicine*
Enzymes

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