Temat: "ENZYME inhibitors" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Kolaflavanone, a biflavonoid derived from medicinal plant Garcinia, is an inhibitor of mitotic kinesin Eg5.
Autorzy:: Alrazi IMD; Department of Bioinformatics, Graduate School of Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo 192-8577, Japan.
Ogunwa TH; Department of Bioinformatics, Graduate School of Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo 192-8577, Japan.
Kolawole AO; Department of Biochemistry, The Federal University of Technology, Akure, Ondo State, PMB 704, Nigeria.
Elekofehinti OO; Department of Biochemistry, The Federal University of Technology, Akure, Ondo State, PMB 704, Nigeria.
Omotuyi OI; Centre for Biocomputing and Drug Design, Biochemistry Department, Adekunle Ajasin University, Akungba-Akoko, Ondo State, PMB 001, Nigeria.
Miyanishi T; Graduate School of Fisheries and Environmental Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki, 852-8521, Japan.
Maruta S; Department of Bioinformatics, Graduate School of Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo 192-8577, Japan.; Pokaż więcej
Źródło:: Journal of biochemistry [J Biochem] 2021 Dec 28; Vol. 170 (5), pp. 611-622.
Typ publikacji:: Journal Article
MeSH Terms:: Biflavonoids*/chemistry
Biflavonoids*/pharmacology
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
Garcinia*/chemistry
Kinesins*/antagonists & inhibitors
Kinesins*/chemistry
Kinesins*/metabolism
Plants, Medicinal*/chemistry
Spindle Apparatus*/drug effects
Spindle Apparatus*/metabolism
Animals ; Mice ; Adenosine Triphosphatases/antagonists & inhibitors ; Mitosis/drug effects ; Molecular Docking Simulation/methods

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Skocz do pozycji: 2.

Tytuł:: Targeting EZH2 as cancer therapy.
Autorzy:: Hanaki S; Department of Biochemistry, Joint Faculty of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8511, Japan.
Shimada M; Department of Biochemistry, Joint Faculty of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8511, Japan.; Pokaż więcej
Źródło:: Journal of biochemistry [J Biochem] 2021 Sep 22; Vol. 170 (1), pp. 1-4.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Antineoplastic Agents/*pharmacology
Enhancer of Zeste Homolog 2 Protein/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Neoplasms/*drug therapy
Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Enzyme Inhibitors/chemistry ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology

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Skocz do pozycji: 3.

Tytuł:: Screening and identification of potential tyrosinase inhibitors from Semen Oroxyli extract by ultrafiltration LC-MS and in silico molecular docking.
Autorzy:: Yin XS; Department of Pharmacy, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei province, PR China.
Zhang XQ; Department of Pharmacy, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei province, PR China.
Yin JT; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, 050000, Hebei province, PR China.
Kong DZ; School of Chinese Integrative Medicine, Hebei Medical University, Shijiazhuang 050000, Hebei province, PR China.
Li DQ; Department of Pharmacy, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei province, PR China.; Pokaż więcej
Źródło:: Journal of chromatographic science [J Chromatogr Sci] 2019 Oct 17; Vol. 57 (9), pp. 838-846.
Typ publikacji:: Journal Article
MeSH Terms:: Bignoniaceae*
Enzyme Inhibitors*/analysis
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/metabolism
Plant Extracts*/analysis
Plant Extracts*/chemistry
Plant Extracts*/metabolism
Drug Discovery/*methods
Monophenol Monooxygenase/*antagonists & inhibitors
Chromatography, High Pressure Liquid/methods ; Flavones/analysis ; Flavones/chemistry ; Flavones/metabolism ; Glucosides/analysis ; Glucosides/chemistry ; Glucosides/metabolism ; Mass Spectrometry/methods ; Molecular Docking Simulation/methods ; Monophenol Monooxygenase/chemistry ; Monophenol Monooxygenase/metabolism ; Ultrafiltration/methods

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Skocz do pozycji: 4.

Tytuł:: A novel angiotensin-I converting enzyme inhibitory peptide derived from the glutelin of vinegar soaked black soybean and its antihypertensive effect in spontaneously hypertensive rats.
Autorzy:: Zhang Y; School of Life Science, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, China.
Zhang Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, China.
Chen P; School of Life Science, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, China.
Shu F; ICF International Inc., 3 Corporate Blvd, NE#100, Atlanta, GA, USA.
Li K; School of Life Science, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, China.
Qiao L; School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, China.
Chen Z; Department of Cardiovascular Surgery, Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 167 North Lishi Road, Xicheng District, Beijing, China.
Wang L; School of Life Science, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing, China.; Pokaż więcej
Źródło:: Journal of biochemistry [J Biochem] 2019 Sep 01; Vol. 166 (3), pp. 223-230.
Typ publikacji:: Journal Article
MeSH Terms:: Angiotensin-Converting Enzyme Inhibitors/*pharmacology
Antihypertensive Agents/*pharmacology
Glutens/*chemistry
Hypertension/*drug therapy
Oligopeptides/*pharmacology
Glycine max/*chemistry
Acetic Acid/chemistry ; Angiotensin-Converting Enzyme Inhibitors/chemistry ; Angiotensin-Converting Enzyme Inhibitors/isolation & purification ; Animals ; Antihypertensive Agents/chemistry ; Antihypertensive Agents/isolation & purification ; Dose-Response Relationship, Drug ; Glutens/isolation & purification ; Hypertension/metabolism ; Male ; Molecular Docking Simulation ; Oligopeptides/chemistry ; Oligopeptides/isolation & purification ; Peptidyl-Dipeptidase A/metabolism ; Rats ; Rats, Inbred SHR ; Structure-Activity Relationship

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Skocz do pozycji: 5.

Tytuł:: Morelloflavone as a novel inhibitor of mitotic kinesin Eg5.
Autorzy:: Ogunwa TH; Department of Environmental Studies, Graduate School of Fisheries and Environmental Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki, Japan.
Taii K; Department of Bioinformatics, Graduate School of Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo, Japan.
Sadakane K; Department of Bioinformatics, Graduate School of Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo, Japan.
Kawata Y; Department of Environmental Studies, Graduate School of Fisheries and Environmental Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki, Japan.
Maruta S; Department of Bioinformatics, Graduate School of Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo, Japan.
Miyanishi T; Department of Environmental Studies, Graduate School of Fisheries and Environmental Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki, Japan.; Pokaż więcej
Źródło:: Journal of biochemistry [J Biochem] 2019 Aug 01; Vol. 166 (2), pp. 129-137.
Typ publikacji:: Journal Article
MeSH Terms:: Mitosis*
Biflavonoids/*pharmacology
Enzyme Inhibitors/*pharmacology
Kinesins/*antagonists & inhibitors
Biflavonoids/chemistry ; Enzyme Inhibitors/chemistry ; Garcinia/chemistry ; Humans ; Kinesins/metabolism ; Models, Molecular ; Molecular Structure ; Plant Leaves/chemistry

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Skocz do pozycji: 6.

Tytuł:: Serum potassium changes due to concomitant ACEI/ARB and spironolactone therapy: A systematic review and meta-analysis.
Autorzy:: Villa-Zapata L; Department of Pharmacy Practice, College of Pharmacy, Mercer University, Atlanta, GA, USA.
Carhart BS; Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Horn JR; Department of Pharmacy Practice, School of Pharmacy, University of Washington, Seattle, WA.; Pharmacy Services, UW Medicine, Seattle, WA, USA.
Hansten PD; School of Pharmacy, University of Washington, Seattle, WA, USA.
Subbian V; Department of Biomedical Engineering and Department of Systems & Industrial Engineering, College of Engineering, The University of Arizona, Tucson, AZ, USA.
Gephart S; Community and Health Systems Science, College of Nursing, The University of Arizona, Tucson, AZ, USA.
Tan M; College of Pharmacy, L.S. Skaggs Research Institute, University of Utah, Salt Lake City, UT, USA.
Romero A; Department of Pharmacy, Banner University Medical Center, Tucson, AZ, USA.
Malone DC; College of Pharmacy, L.S. Skaggs Research Institute, University of Utah, Salt Lake City, UT, USA.; Pokaż więcej
Źródło:: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists [Am J Health Syst Pharm] 2021 Dec 09; Vol. 78 (24), pp. 2245-2255.
Typ publikacji:: Journal Article; Meta-Analysis; Systematic Review
MeSH Terms:: Angiotensin Receptor Antagonists*
Spironolactone*/adverse effects
Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Humans ; Potassium ; Reproducibility of Results

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Skocz do pozycji: 7.

Tytuł:: Evaluation of compound selectivity of aldo-keto reductases using differential scanning fluorimetry.
Autorzy:: Kabir A; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Endo S; Labolatory of Biochemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi Gifu 501-1196, Japan.
Toyooka N; Graduate School of Science and Engineering, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan.
Fukuoka M; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Kuwata K; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.; Department of Gene and Development, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Kamatari YO; Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.; Pokaż więcej
Źródło:: Journal of biochemistry [J Biochem] 2017 Feb 01; Vol. 161 (2), pp. 215-222.
Typ publikacji:: Journal Article
MeSH Terms:: Aldehyde Reductase/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Fluorometry/*methods
Aldehyde Reductase/chemistry ; Aldehyde Reductase/metabolism ; Aldo-Keto Reductases ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Enzyme Assays/methods ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/classification ; Isoenzymes/genetics ; Models, Chemical ; Models, Molecular ; Molecular Structure ; Phylogeny ; Protein Domains ; Reproducibility of Results

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Skocz do pozycji: 8.

Tytuł:: Plants with increased expression of ent-kaurene oxidase are resistant to chemical inhibitors of this gibberellin biosynthesis enzyme.
Autorzy:: Swain SM; CSIRO Plant Industry, 585 River Ave, Merbein, Victoria 3505, Australia. />Singh DP
Helliwell CA
Poole AT; Pokaż więcej
Źródło:: Plant & cell physiology [Plant Cell Physiol] 2005 Feb; Vol. 46 (2), pp. 284-91. Date of Electronic Publication: 2005 Feb 02.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cytochrome P-450 Enzyme Inhibitors*
Arabidopsis/*enzymology
Cytochrome P-450 Enzyme System/*metabolism
Enzyme Inhibitors/*pharmacology
Gibberellins/*biosynthesis
Oxygenases/*antagonists & inhibitors
Oxygenases/*metabolism
Arabidopsis/genetics ; Arabidopsis/growth & development ; Caulimovirus/genetics ; Cytochrome P-450 Enzyme System/genetics ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Plant ; Germination/drug effects ; Gibberellins/metabolism ; Green Fluorescent Proteins/genetics ; Oxygenases/genetics ; Plants, Genetically Modified ; Pollen/drug effects ; Pollen/physiology ; Promoter Regions, Genetic/genetics ; RNA, Messenger/metabolism ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Seedlings/physiology ; Seeds/physiology ; Triazoles/pharmacology

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Skocz do pozycji: 9.

Tytuł:: Biochemical and Chemical Biology Study of Rice OsTAR1 Revealed that Tryptophan Aminotransferase is Involved in Auxin Biosynthesis: Identification of a Potent OsTAR1 Inhibitor, Pyruvamine2031.
Autorzy:: Kakei Y; Yokohama City University, Kihara Institute for Biological Research, Maiokacho 641-12, Totsuka, Yokohama, Kanagawa, 244-0813 Japan.
Nakamura A; Yokohama City University, Kihara Institute for Biological Research, Maiokacho 641-12, Totsuka, Yokohama, Kanagawa, 244-0813 Japan.
Yamamoto M; Yokohama City University, Kihara Institute for Biological Research, Maiokacho 641-12, Totsuka, Yokohama, Kanagawa, 244-0813 Japan.
Ishida Y; Yokohama City University, Kihara Institute for Biological Research, Maiokacho 641-12, Totsuka, Yokohama, Kanagawa, 244-0813 Japan.
Yamazaki C; Yokohama City University, Kihara Institute for Biological Research, Maiokacho 641-12, Totsuka, Yokohama, Kanagawa, 244-0813 Japan.
Sato A; Yokohama City University, Kihara Institute for Biological Research, Maiokacho 641-12, Totsuka, Yokohama, Kanagawa, 244-0813 Japan.
Narukawa-Nara M; Yokohama City University, Kihara Institute for Biological Research, Maiokacho 641-12, Totsuka, Yokohama, Kanagawa, 244-0813 Japan.; Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba, 278-8510 Japan.
Soeno K; National Agriculture and Food Research Organization (NARO), Western Region Agricultural Research Center (WARC), Senyu, Zentsuji, Kagawa, 765-8508 Japan.
Shimada Y; Yokohama City University, Kihara Institute for Biological Research, Maiokacho 641-12, Totsuka, Yokohama, Kanagawa, 244-0813 Japan.; Pokaż więcej
Źródło:: Plant & cell physiology [Plant Cell Physiol] 2017 Mar 01; Vol. 58 (3), pp. 598-606.
Typ publikacji:: Journal Article
MeSH Terms:: Enzyme Inhibitors/*pharmacology
Indoleacetic Acids/*metabolism
Indoles/*metabolism
Oryza/*enzymology
Oryza/*metabolism
Tryptophan/*metabolism
Tryptophan Transaminase/*drug effects
Tryptophan Transaminase/*metabolism
Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Biosynthetic Pathways/drug effects ; Biosynthetic Pathways/genetics ; Enzyme Inhibitors/chemistry ; Gene Expression Regulation, Plant/drug effects ; Indoles/chemistry ; Oryza/drug effects ; Oryza/genetics ; Plant Roots/metabolism ; Recombinant Proteins ; Seedlings/metabolism ; Tryptophan Transaminase/genetics

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Skocz do pozycji: 10.

Tytuł:: Antihypertensive prescribing patterns and hypertension control in females of childbearing age.
Autorzy:: White BM; Billings Clinic, Billings, MT, USA.
Anderson SL; University of Colorado Skaggs School of Pharmacy & Pharmaceutical Sciences, Aurora, CO, USA.
Marrs JC; University of Colorado Skaggs School of Pharmacy & Pharmaceutical Sciences, Aurora, CO, USA.; Pokaż więcej
Źródło:: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists [Am J Health Syst Pharm] 2021 Jul 09; Vol. 78 (14), pp. 1317-1322.
Typ publikacji:: Journal Article
MeSH Terms:: Antihypertensive Agents*/adverse effects
Hypertension*/diagnosis
Hypertension*/drug therapy
Hypertension*/epidemiology
Adult ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Cross-Sectional Studies ; Female ; Humans ; Pregnancy ; Retrospective Studies

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Skocz do pozycji: 11.

Tytuł:: Lonafarnib.
Źródło:: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists [Am J Health Syst Pharm] 2021 Apr 22; Vol. 78 (9), pp. 755-757.
Typ publikacji:: Journal Article
MeSH Terms:: Piperidines*
Pyridines*/adverse effects
Enzyme Inhibitors ; Humans

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Skocz do pozycji: 12.

Tytuł:: A comprehensive drug repurposing study for COVID19 treatment: novel putative dihydroorotate dehydrogenase inhibitors show association to serotonin-dopamine receptors.
Autorzy:: Berber B; Eskisehir Technical University, Department of Biology.
Doluca O; Massey University, New Zealand.; Pokaż więcej
Źródło:: Briefings in bioinformatics [Brief Bioinform] 2021 Mar 22; Vol. 22 (2), pp. 1023-1037.
Typ publikacji:: Journal Article
MeSH Terms:: Drug Repositioning*
Antiviral Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Oxidoreductases Acting on CH-CH Group Donors/*antagonists & inhibitors
Receptors, Dopamine/*drug effects
Receptors, Serotonin/*drug effects
Computer Simulation ; Dihydroorotate Dehydrogenase ; Humans ; Molecular Docking Simulation ; Oxidoreductases Acting on CH-CH Group Donors/chemistry ; SARS-CoV-2 ; COVID-19 Drug Treatment

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Skocz do pozycji: 13.

Tytuł:: ABIN3 Negatively Regulates Necroptosis-induced Intestinal Inflammation Through Recruiting A20 and Restricting the Ubiquitination of RIPK3 in Inflammatory Bowel Disease.
Autorzy:: Zhou M; Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.
He J; Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Shi Y; Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.
Liu X; Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.
Luo S; Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.
Cheng C; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.
Ge W; Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qu C; Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Du P; Department of Colorectal Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen Y; Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.; Pokaż więcej
Źródło:: Journal of Crohn's & colitis [J Crohns Colitis] 2021 Jan 13; Vol. 15 (1), pp. 99-114.
Typ publikacji:: Journal Article
MeSH Terms:: Inflammatory Bowel Diseases*/immunology
Inflammatory Bowel Diseases*/metabolism
Receptor-Interacting Protein Serine-Threonine Kinases*/antagonists & inhibitors
Receptor-Interacting Protein Serine-Threonine Kinases*/metabolism
Adaptor Proteins, Signal Transducing/*metabolism
Benzothiazoles/*pharmacology
Imidazoles/*pharmacology
Indoles/*pharmacology
Quinolines/*pharmacology
Tumor Necrosis Factor alpha-Induced Protein 3/*metabolism
Animals ; Enzyme Inhibitors/pharmacology ; Inflammation/metabolism ; Mice ; Mice, Inbred C57BL ; Necroptosis/drug effects ; Signal Transduction/drug effects ; Ubiquitination/drug effects

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Skocz do pozycji: 14.

Tytuł:: Characterization of hamster NAD+-dependent 3(17)β-hydroxysteroid dehydrogenase belonging to the aldo-keto reductase 1C subfamily.
Autorzy:: Endo S; Laboratory of Biochemistry and.
Noda M; Laboratory of Biochemistry and.
Ikari A; Laboratory of Biochemistry and.
Tatematsu K; Laboratory of Radiochemistry, Gifu Pharmaceutical University, Gifu 501-1196, Japan;
El-Kabbani O; Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; and.
Hara A; Faculty of Engineering, Gifu University, Gifu 501-1193, Japan.
Kitade Y; Faculty of Engineering, Gifu University, Gifu 501-1193, Japan.
Matsunaga T; Laboratory of Biochemistry and .; Pokaż więcej
Źródło:: Journal of biochemistry [J Biochem] 2015 Nov; Vol. 158 (5), pp. 425-34. Date of Electronic Publication: 2015 May 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: 17-Hydroxysteroid Dehydrogenases/*metabolism
Alcohol Oxidoreductases/*metabolism
Enzyme Inhibitors/*pharmacology
Estradiol Dehydrogenases/*metabolism
Flavonoids/*pharmacology
Liver/*enzymology
NAD/*metabolism
17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors ; 17-Hydroxysteroid Dehydrogenases/genetics ; Alcohol Oxidoreductases/antagonists & inhibitors ; Alcohol Oxidoreductases/genetics ; Amino Acid Substitution ; Animals ; Binding, Competitive ; Enzyme Inhibitors/metabolism ; Estradiol Dehydrogenases/antagonists & inhibitors ; Estradiol Dehydrogenases/genetics ; Female ; Flavonoids/metabolism ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Liver/metabolism ; Male ; Mesocricetus ; Mutagenesis, Site-Directed ; Mutant Proteins/metabolism ; Organ Specificity ; Oxidation-Reduction ; RNA, Messenger/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Sex Characteristics ; Substrate Specificity

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Skocz do pozycji: 15.

Tytuł:: Involvement of nitric oxide in serotonin-induced scratching in mice.
Autorzy:: Ostadhadi S; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Haj-Mirzaian A; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Azimi E; Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA.
Mansouri P; Skin and Stem cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Dehpour AR; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.; Pokaż więcej
Źródło:: Clinical and experimental dermatology [Clin Exp Dermatol] 2015 Aug; Vol. 40 (6), pp. 647-52. Date of Electronic Publication: 2015 Feb 22.
Typ publikacji:: Journal Article
MeSH Terms:: Enzyme Inhibitors*
Serotonin*
Serotonin Receptor Agonists*
Nitric Oxide/*physiology
Pruritus/*chemically induced
Analysis of Variance ; Animals ; Arginine/pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Guanidines/pharmacology ; Injections, Intradermal ; Male ; Mice ; NG-Nitroarginine Methyl Ester ; Nitric Oxide Synthase/antagonists & inhibitors ; Pruritus/physiopathology

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Skocz do pozycji: 16.

Tytuł:: Targeting histone methyltransferase EZH2 as cancer treatment.
Autorzy:: Kondo Y; Department of Epigenomics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan .; Pokaż więcej
Źródło:: Journal of biochemistry [J Biochem] 2014 Nov; Vol. 156 (5), pp. 249-57. Date of Electronic Publication: 2014 Aug 31.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Neoplasms/*drug therapy
Polycomb Repressive Complex 2/*antagonists & inhibitors
Small Molecule Libraries/*pharmacology
Antineoplastic Agents/chemistry ; Enhancer of Zeste Homolog 2 Protein ; Enzyme Inhibitors/chemistry ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology ; Polycomb Repressive Complex 2/genetics ; Polycomb Repressive Complex 2/metabolism ; Small Molecule Libraries/chemistry

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Skocz do pozycji: 17.

Tytuł:: Modulation of the kallikrein/kinin system by the angiotensin-converting enzyme inhibitor alleviates experimental autoimmune encephalomyelitis.
Autorzy:: Uzawa A; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Mori M
Taniguchi J
Kuwabara S; Pokaż więcej
Źródło:: Clinical and experimental immunology [Clin Exp Immunol] 2014 Nov; Vol. 178 (2), pp. 245-52.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Angiotensin-Converting Enzyme Inhibitors/*pharmacology
Encephalomyelitis, Autoimmune, Experimental/*metabolism
Kallikreins/*metabolism
Angiotensin-Converting Enzyme Inhibitors/administration & dosage ; Animals ; Bradykinin/analogs & derivatives ; Bradykinin/blood ; Bradykinin/metabolism ; Bradykinin/pharmacology ; Cytokines/blood ; Cytokines/metabolism ; Demyelinating Diseases/drug therapy ; Demyelinating Diseases/metabolism ; Disease Models, Animal ; Enalapril/administration & dosage ; Enalapril/pharmacology ; Encephalomyelitis, Autoimmune, Experimental/drug therapy ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Female ; Mice ; Multiple Sclerosis/metabolism ; Severity of Illness Index ; Th17 Cells/immunology ; Th17 Cells/pathology

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Skocz do pozycji: 18.

Tytuł:: Genotype-based treatment approved for type 1 Gaucher disease.
Autorzy:: Thompson CA; Pokaż więcej
Źródło:: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists [Am J Health Syst Pharm] 2014 Oct 01; Vol. 71 (19), pp. 1606.
Typ publikacji:: Journal Article
MeSH Terms:: Enzyme Inhibitors/*therapeutic use
Gaucher Disease/*drug therapy
Pyrrolidines/*therapeutic use
Adult ; Drug Approval ; Enzyme Inhibitors/pharmacology ; Gaucher Disease/genetics ; Genotype ; Humans ; Pyrrolidines/pharmacology ; United States ; United States Food and Drug Administration

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Tytuł:: Prescription Opioids induce Gut Dysbiosis and Exacerbate Colitis in a Murine Model of Inflammatory Bowel Disease.
Autorzy:: Sharma U; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Olson RK; Department of Surgery, University of Minnesota, Minneapolis, MN, USA.
Erhart FN; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Zhang L; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Meng J; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Segura B; Department of Surgery, University of Minnesota, Minneapolis, MN, USA.
Banerjee S; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Sharma M; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Saluja AK; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Ramakrishnan S; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Abreu MT; Division of Gastroenterology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Roy S; Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.; Pokaż więcej
Źródło:: Journal of Crohn's & colitis [J Crohns Colitis] 2020 Jul 09; Vol. 14 (6), pp. 801-817.
Typ publikacji:: Journal Article
MeSH Terms:: Dysbiosis*/chemically induced
Dysbiosis*/microbiology
Dysbiosis*/physiopathology
Dysbiosis*/prevention & control
Gastrointestinal Microbiome*/drug effects
Gastrointestinal Microbiome*/physiology
Hydromorphone*/administration & dosage
Hydromorphone*/adverse effects
Inflammatory Bowel Diseases*/drug therapy
Inflammatory Bowel Diseases*/immunology
Inflammatory Bowel Diseases*/microbiology
Azepines/*pharmacology
Myosin-Light-Chain Kinase/*antagonists & inhibitors
Naphthalenes/*pharmacology
Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/adverse effects ; Animals ; Disease Models, Animal ; Enzyme Inhibitors/pharmacology ; Interleukin-10/genetics ; Mice ; Mice, Knockout ; Pain Management/adverse effects ; Pain Management/methods

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Tytuł:: A leukotriene C4 synthase inhibitor with the backbone of 5-(5-methylene-4-oxo-4,5-dihydrothiazol-2-ylamino) isophthalic acid.
Autorzy:: Ago H; Structural Biophysics Laboratory, RIKEN SPring-8 Center, Harima Institute, 1-1-1 Kouto, Sayo, Hyogo 679-5148, Japan, USA. />Okimoto N
Kanaoka Y
Morimoto G
Ukita Y
Saino H
Taiji M
Miyano M; Pokaż więcej
Źródło:: Journal of biochemistry [J Biochem] 2013 May; Vol. 153 (5), pp. 421-9. Date of Electronic Publication: 2013 Jan 31.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Enzyme Inhibitors/*pharmacology
Glutathione Transferase/*antagonists & inhibitors
Phthalic Acids/*pharmacology
Enzyme Inhibitors/chemistry ; Molecular Structure ; Phthalic Acids/chemistry

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