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Tytuł :
[Establishment of an in vitro model of alveolar macrophage cell efferocytosis dysfunction].
Autorzy :
Lou X; Henan University of Traditional Chinese Medicine (TCM), Henan Key Laboratory of TCM Prescription and Syndrome Signaling, Zhengzhou 450046, Henan, China. Corresponding author: Cui Shanshan, Email: .
Chen Y
Liu X
Wu Y
Li C
Shang Y
Gao X
Cui S
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Źródło :
Zhonghua wei zhong bing ji jiu yi xue [Zhonghua Wei Zhong Bing Ji Jiu Yi Xue] 2021 Jan; Vol. 33 (1), pp. 38-42.
Typ publikacji :
Journal Article
MeSH Terms :
Alveolar Epithelial Cells*
Macrophages, Alveolar*
Animals ; Cell Line ; Epithelial Cells ; Rats ; Smoke
Czasopismo naukowe
Tytuł :
A transitional stem cell state in the lung.
Autorzy :
Verheyden JM; Department of Pediatrics, University of California, San Diego, San Diego, CA, USA.
Sun X; Department of Pediatrics, University of California, San Diego, San Diego, CA, USA. .; Department of Biological Sciences, University of California, San Diego, San Diego, CA, USA. .
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Źródło :
Nature cell biology [Nat Cell Biol] 2020 Sep; Vol. 22 (9), pp. 1025-1026.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Alveolar Epithelial Cells*
Pulmonary Fibrosis*
Epithelial Cells ; Humans ; Stem Cells
Czasopismo naukowe
Tytuł :
Single-cell transcriptome profiling reveals the mechanism of abnormal proliferation of epithelial cells in congenital cystic adenomatoid malformation.
Autorzy :
Zhang S; Department of General Surgery, Jiangxi Provincial Children's Hospital, Jiangxi, China; Department of Pediatrics, The Affiliated Children's Hospital of Nanchang University, Jiangxi, China.
Ye C; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China.
Xiao J; Department of Ultrasound, Jiangxi Provincial Maternal and Child Health Hospital, Jiangxi, China.
Yang J; Department of Pediatrics, The Affiliated Children's Hospital of Nanchang University, Jiangxi, China.
Zhu C; Department of General Surgery, Jiangxi Provincial Children's Hospital, Jiangxi, China; Department of Pediatrics, The Affiliated Children's Hospital of Nanchang University, Jiangxi, China.
Xiao Y; Department of General Surgery, Jiangxi Provincial Children's Hospital, Jiangxi, China; Department of Pediatrics, The Affiliated Children's Hospital of Nanchang University, Jiangxi, China.
Ye M; Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China. Electronic address: .
Chen Q; Department of General Surgery, Jiangxi Provincial Children's Hospital, Jiangxi, China; Department of Pediatrics, The Affiliated Children's Hospital of Nanchang University, Jiangxi, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2020 Nov 15; Vol. 396 (2), pp. 112299. Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Profiling*
Single-Cell Analysis*
Cystic Adenomatoid Malformation of Lung, Congenital/*genetics
Cystic Adenomatoid Malformation of Lung, Congenital/*pathology
Epithelial Cells/*metabolism
Epithelial Cells/*pathology
Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/pathology ; Cell Lineage/genetics ; Cell Proliferation/genetics ; Child, Preschool ; Humans ; Lung/metabolism ; Lung/pathology ; Mast Cells/metabolism
Czasopismo naukowe
Tytuł :
Single-Cell Reconstruction of Human Basal Cell Diversity in Normal and Idiopathic Pulmonary Fibrosis Lungs.
Autorzy :
Carraro G; Lung and Regenerative Medicine Institutes, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Mulay A; Lung and Regenerative Medicine Institutes, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Yao C; Lung and Regenerative Medicine Institutes, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Mizuno T; Lung and Regenerative Medicine Institutes, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Konda B; Lung and Regenerative Medicine Institutes, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Petrov M; Lung and Regenerative Medicine Institutes, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Lafkas D; Genentech Inc., San Francisco, California.
Arron JR; Genentech Inc., San Francisco, California.
Hogaboam CM; Lung and Regenerative Medicine Institutes, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Chen P; Lung and Regenerative Medicine Institutes, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Jiang D; Lung and Regenerative Medicine Institutes, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Noble PW; Lung and Regenerative Medicine Institutes, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Randell SH; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina; and.
McQualter JL; Lung and Regenerative Medicine Institutes, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.; School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia.
Stripp BR; Lung and Regenerative Medicine Institutes, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2020 Dec 01; Vol. 202 (11), pp. 1540-1550.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Plasticity*
Cell Proliferation/*genetics
Cell Self Renewal/*genetics
Epithelial Cells/*cytology
Idiopathic Pulmonary Fibrosis/*genetics
Respiratory Mucosa/*cytology
Aged ; Alveolar Epithelial Cells/cytology ; Alveolar Epithelial Cells/metabolism ; Basement Membrane ; Case-Control Studies ; Epithelial Cells/metabolism ; Female ; Gene Expression Profiling ; Humans ; Idiopathic Pulmonary Fibrosis/metabolism ; Male ; Middle Aged ; RNA-Seq ; Respiratory Mucosa/metabolism ; Single-Cell Analysis ; Transcriptome ; Young Adult
Czasopismo naukowe
Tytuł :
A new mixed-ligand coordination polymer: protective activity on influenza a virus-induced COPD via regulating tlr3 gene expression on alveolar epithelial cells.
Autorzy :
Tu Y; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yang C; Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Zhang X; Department of Respiratory and Critical Care Medicine, Wuxi Branch of Ruijin Hospital, Wuxi, China.
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Źródło :
Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2021 Jan; Vol. 47 (1), pp. 92-99. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article
MeSH Terms :
Influenza A virus*
Pulmonary Disease, Chronic Obstructive*
Alveolar Epithelial Cells/*chemistry
Epithelial Cells ; Gene Expression ; Humans ; Ligands ; Molecular Docking Simulation ; Polymers/chemistry ; Toll-Like Receptor 3/chemistry ; Toll-Like Receptor 3/genetics ; Toll-Like Receptor 3/metabolism
Czasopismo naukowe
Tytuł :
Epigallocatechin gallate diminishes cigarette smoke-induced oxidative stress, lipid peroxidation, and inflammation in human bronchial epithelial cells.
Autorzy :
Lakshmi SP; Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India. Electronic address: .
Reddy AT; Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India.
Kodidhela LD; Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India.
Varadacharyulu NC; Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India.
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Źródło :
Life sciences [Life Sci] 2020 Oct 15; Vol. 259, pp. 118260. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
Alveolar Epithelial Cells/*drug effects
Catechin/*analogs & derivatives
Cigarette Smoking/*drug therapy
Aldehydes/pharmacology ; Alveolar Epithelial Cells/metabolism ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Bronchi/metabolism ; Catechin/metabolism ; Catechin/pharmacology ; Cell Line ; Cigarette Smoking/adverse effects ; Cigarette Smoking/physiopathology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Humans ; Inflammation/metabolism ; Lipid Peroxidation/drug effects ; NF-kappa B/metabolism ; Oxidation-Reduction/drug effects ; Oxidative Stress/drug effects ; Pulmonary Alveoli/metabolism ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Reactive Oxygen Species ; Signal Transduction/drug effects ; Smoke/adverse effects ; Smoking/adverse effects
Czasopismo naukowe
Tytuł :
Prematurity negatively affects regenerative properties of human amniotic epithelial cells in the context of lung repair.
Autorzy :
Zhu D; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria 3800, Australia.
Kusuma GD; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria 3800, Australia.
Schwab R; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria 3800, Australia.
Chan ST; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria 3800, Australia.
Tan J; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria 3800, Australia.
Saad MI; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria 3800, Australia.
Leeman KT; School of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; Division of Newborn Medicine, Department of Paediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA, U.S.A.
Kim C; Boston Children's Hospital Boston Stem Cell Program, Department of Genetics, Harvard Medical School and Harvard Stem Cell Institute, MA, U.S.A.
Wallace EM; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria 3800, Australia.
Lim R; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria 3800, Australia.
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Źródło :
Clinical science (London, England : 1979) [Clin Sci (Lond)] 2020 Oct 30; Vol. 134 (20), pp. 2665-2679.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Regeneration*
Amnion/*cytology
Epithelial Cells/*cytology
Lung/*physiology
Premature Birth/*pathology
Alveolar Epithelial Cells/cytology ; Animals ; Bleomycin ; Female ; Fluorescent Antibody Technique ; Gene Expression Regulation ; Humans ; Ligands ; Mice, Inbred C57BL ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Organoids/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-myc/metabolism ; Stem Cells/cytology ; Transcription, Genetic ; Wnt Signaling Pathway/genetics ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
Bioprinting for Human Respiratory and Gastrointestinal In Vitro Models.
Autorzy :
Estermann M; Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland.
Bisig C; Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland.; Comprehensive Molecular Analytics, Helmholtz Center Munich, Munich, Germany.
Septiadi D; Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland.
Petri-Fink A; Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland.
Rothen-Rutishauser B; Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2020; Vol. 2140, pp. 199-215.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biocompatible Materials*
Epithelial Cells*
Printing, Three-Dimensional*
Bioprinting/*methods
Tissue Engineering/*methods
A549 Cells ; Alveolar Epithelial Cells ; Automation ; Bronchi/cytology ; Caco-2 Cells ; Drug Evaluation, Preclinical ; Electric Impedance ; Equipment Design ; Gastrointestinal Tract/cytology ; Humans ; In Vitro Techniques ; Intestinal Mucosa/cytology ; L-Lactate Dehydrogenase/analysis ; Microscopy, Confocal ; Microscopy, Fluorescence ; Toxicity Tests
Czasopismo naukowe
Tytuł :
Cigarette smoke extract induces pyroptosis in human bronchial epithelial cells through the ROS/NLRP3/caspase-1 pathway.
Autorzy :
Zhang MY; Department of Pulmonary and Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Jiang YX; Department of Pulmonary and Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Yang YC; Department of Pulmonary and Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Liu JY; Department of Pulmonary and Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Huo C; Department of Pulmonary and Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Ji XL; Department of Pulmonary Disease, Jinan Traditional Chinese Medicine Hospital, Jinan 250012, China.
Qu YQ; Department of Pulmonary and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan 250012, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Mar 15; Vol. 269, pp. 119090. Date of Electronic Publication: 2021 Jan 16.
Typ publikacji :
Journal Article
MeSH Terms :
Pyroptosis*
Bronchi/*pathology
Caspase 1/*metabolism
Epithelial Cells/*pathology
NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
Pulmonary Disease, Chronic Obstructive/*pathology
Reactive Oxygen Species/*metabolism
Smoke/*adverse effects
Animals ; Bronchi/drug effects ; Bronchi/metabolism ; Caspase 1/genetics ; Disease Models, Animal ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Humans ; Inflammasomes/drug effects ; Inflammasomes/metabolism ; Inflammation/etiology ; Inflammation/metabolism ; Inflammation/pathology ; Male ; Mice ; Mice, Inbred C57BL ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Oxidative Stress/drug effects ; Pulmonary Disease, Chronic Obstructive/etiology ; Pulmonary Disease, Chronic Obstructive/metabolism ; Signal Transduction ; Tobacco
Czasopismo naukowe
Tytuł :
The cytoprotective effects of dihydromyricetin and associated metabolic pathway changes on deoxynivalenol treated IPEC-J2 cells.
Autorzy :
Long H; Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Xin Z; Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Zhang F; Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Zhai Z; Jiangxi Functional Feed Additive Engineering Laboratory, Institute of Biological Resource, Jiangxi Academy of Sciences, Nanchang, China.
Ni X; Yunnan Animal Science and Veterinary Institute, Kunming, Yunnan, China.
Chen J; Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Yang K; Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Liao P; Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Zhang L; Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Xiao Z; Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Sindaye D; Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
Deng B; Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Feb 15; Vol. 338, pp. 128116. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article
MeSH Terms :
Cytoprotection/*drug effects
Epithelial Cells/*cytology
Epithelial Cells/*drug effects
Flavonols/*pharmacology
Trichothecenes/*pharmacology
Animals ; Cell Line ; Cell Survival/drug effects ; Epithelial Cells/metabolism ; Swine
Czasopismo naukowe
Tytuł :
Clinical and molecular characterization of the R751L-CFTR mutation.
Autorzy :
Haq IJ; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.; Paediatric Respiratory Medicine, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
Althaus M; Institute for Functional Gene Analytics, Department of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, Rheinbach, Germany.
Gardner AI; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Yeoh HY; Cellular Protein Chemistry, Science4Life, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Joshi U; Cellular Protein Chemistry, Science4Life, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Saint-Criq V; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Verdon B; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Townshend J; Paediatric Respiratory Medicine, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
O'Brien C; Paediatric Respiratory Medicine, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
Ben-Hamida M; Department of Paediatrics, West Cumberland Hospital, Whitehaven, United Kingdom.
Thomas M; Paediatric Respiratory Medicine, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
Bourke S; Respiratory Medicine, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
van der Sluijs P; Cellular Protein Chemistry, Science4Life, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Braakman I; Cellular Protein Chemistry, Science4Life, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Ward C; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Gray MA; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Brodlie M; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.; Paediatric Respiratory Medicine, Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2021 Feb 01; Vol. 320 (2), pp. L288-L300. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bronchi*/metabolism
Bronchi*/pathology
Cystic Fibrosis*/genetics
Cystic Fibrosis*/metabolism
Cystic Fibrosis*/pathology
Cystic Fibrosis Transmembrane Conductance Regulator*/genetics
Cystic Fibrosis Transmembrane Conductance Regulator*/metabolism
Epithelial Cells*/metabolism
Epithelial Cells*/pathology
Mutation, Missense*
Sodium Chloride/*metabolism
Amino Acid Substitution ; Animals ; Female ; Humans ; Male ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Overexpression of the SARS-CoV-2 receptor ACE2 is induced by cigarette smoke in bronchial and alveolar epithelia.
Autorzy :
Liu A; Department of Geriatrics, Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, PR China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, PR China.
Zhang X; Clinical Experimental Center, Jiangmen Key Laboratory of Clinical Biobanks and Translational Research, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, PR China.
Li R; Department of Pathology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, PR China.
Zheng M; Clinical Experimental Center, Jiangmen Key Laboratory of Clinical Biobanks and Translational Research, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, PR China.
Yang S; Department of Geriatrics, Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, PR China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, PR China.
Dai L; Department of Geriatrics, Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, PR China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, PR China.
Wu A; Center for Healthcare-associated Infection Control, Xiangya Hospital, Central South University, Changsha, PR China.
Hu C; Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, PR China.
Huang Y; Clinical Experimental Center, Jiangmen Key Laboratory of Clinical Biobanks and Translational Research, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, PR China.
Xie M; Department of Geriatrics, Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, PR China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, PR China.
Chen Q; Department of Geriatrics, Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, PR China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, PR China.
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Źródło :
The Journal of pathology [J Pathol] 2021 Jan; Vol. 253 (1), pp. 17-30. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alveolar Epithelial Cells/*enzymology
Angiotensin-Converting Enzyme 2/*metabolism
Bronchi/*enzymology
COVID-19/*virology
Epithelial Cells/*virology
Smoking/*adverse effects
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alveolar Epithelial Cells/virology ; Animals ; Child ; Child, Preschool ; Disease Models, Animal ; Epithelial Cells/metabolism ; Female ; Humans ; Infant ; Lung/metabolism ; Lung/virology ; Middle Aged ; SARS-CoV-2 ; Young Adult
Czasopismo naukowe
Tytuł :
Micronucleus Formation in Primary Oropharyngeal Epithelial Cells Reveals Mutagenicity of Cement Dusts.
Autorzy :
Pawliczak J; Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Leipzig, Germany.; Department of Otolaryngology, Head and Neck Surgery, Krankenhaus Martha-Maria, Halle/Saale, Germany.
Kolb M; Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Leipzig, Germany.
Bauer M; Department of Environmental Immunology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.
Gminski R; Institute of Environmental Health Sciences and Hospital Infection Control, Department of Environmental Toxicology and Nanotoxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Dietz A; Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Leipzig, Germany.
Wichmann G; Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Leipzig, Germany; .
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Źródło :
Anticancer research [Anticancer Res] 2021 Apr; Vol. 41 (4), pp. 1849-1858.
Typ publikacji :
Journal Article
MeSH Terms :
Dust*
Construction Materials/*toxicity
Epithelial Cells/*drug effects
Micronuclei, Chromosome-Defective/*chemically induced
Mouth Mucosa/*drug effects
Cells, Cultured ; Dose-Response Relationship, Drug ; Epithelial Cells/pathology ; Female ; Humans ; Laryngeal Neoplasms/chemically induced ; Laryngeal Neoplasms/pathology ; Male ; Micronucleus Tests ; Mouth Mucosa/pathology ; Primary Cell Culture ; Risk Assessment ; Squamous Cell Carcinoma of Head and Neck/chemically induced ; Squamous Cell Carcinoma of Head and Neck/pathology
Czasopismo naukowe
Tytuł :
Epigenetically regulated digital signaling defines epithelial innate immunity at the tissue level.
Autorzy :
Clark HR; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Oncology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
McKenney C; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Oncology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Livingston NM; The Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Gershman A; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Sajjan S; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Oncology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Chan IS; Oncology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ewald AJ; Oncology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Timp W; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Wu B; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Singh A; Electrical and Computer Engineering, University of Delaware, Newark, DE, USA.
Regot S; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Oncology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 23; Vol. 12 (1), pp. 1836. Date of Electronic Publication: 2021 Mar 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Immunity, Innate*/drug effects
Immunity, Innate*/genetics
Bacteria/*immunology
Epithelial Cells/*immunology
Lipopeptides/*immunology
NF-kappa B/*metabolism
Toll-Like Receptor 2/*metabolism
Animals ; Bacteria/metabolism ; Cell Line ; Cytokines/metabolism ; Cytokines/pharmacology ; DNA Methylation/drug effects ; Epigenesis, Genetic/drug effects ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Flagellin/pharmacology ; Gene Expression Regulation/genetics ; Gene Expression Regulation/immunology ; Humans ; Image Processing, Computer-Assisted ; In Situ Hybridization, Fluorescence ; Mammary Glands, Animal ; Mice ; Organoids/drug effects ; Organoids/immunology ; Organoids/metabolism ; Promoter Regions, Genetic ; RNA-Seq ; Signal Transduction/immunology ; Single-Cell Analysis ; Toll-Like Receptor 2/agonists ; Toll-Like Receptor 2/genetics ; Toll-Like Receptors/agonists ; Toll-Like Receptors/metabolism
Czasopismo naukowe
Tytuł :
[Effects of Acrolein on the Proliferation of and Per 1 Gene Expression in Pulmonary Epithelial Cells].
Autorzy :
Li CM; Department of Occupational and Environmental Health, School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
Liu Y; Department of Histology and Embryology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China.
Xu LM; Department of Occupational and Environmental Health, School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
Wu WD; Department of Occupational and Environmental Health, School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
Jiang BJ; Department of Occupational and Environmental Health, School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
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Źródło :
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition [Sichuan Da Xue Xue Bao Yi Xue Ban] 2021 Mar; Vol. 52 (2), pp. 216-221.
Typ publikacji :
Journal Article
MeSH Terms :
Acrolein*/pharmacology
Epithelial Cells*
Cell Proliferation ; Gene Expression ; Lung
Czasopismo naukowe
Tytuł :
Halting SARS-CoV-2: lung organoids step up to the plate.
Autorzy :
Leibel SL; Department of Pediatrics, University of California at San Diego, La Jolla, CA, USA.
Sun X; Department of Pediatrics, University of California at San Diego, La Jolla, CA, USA.; Department of Biological Sciences, University of California at San Diego, La Jolla, CA, USA.
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Źródło :
The EMBO journal [EMBO J] 2021 Mar 01; Vol. 40 (5), pp. e107651. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Biological*
Virus Replication*
Alveolar Epithelial Cells/*metabolism
COVID-19/*metabolism
Organoids/*metabolism
SARS-CoV-2/*physiology
Alveolar Epithelial Cells/pathology ; Alveolar Epithelial Cells/virology ; COVID-19/drug therapy ; COVID-19/pathology ; Humans ; Organoids/pathology ; Organoids/virology
Czasopismo naukowe
Tytuł :
Galectin-7 overexpression destroys airway epithelial barrier in transgenic mice.
Autorzy :
Tian J; Department of Respiratory Medicine II, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
He R; Department of Respiratory Medicine II, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Fan Y; Department of Respiratory Medicine II, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Zhang Q; Department of Respiratory Medicine II, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Tian B; Department of Respiratory Medicine II, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Zhou C; Virus Laboratory, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China.
Liu C; Virus Laboratory, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, China.
Song M; Key Laboratory of Human Disease Comparative Medicine, National Health Commission of China (NHC), Beijing Engineering Research Center for Experimental Animal Models of Human Diseases, Institute of Laboratory Animal Science, Peking Union Medicine College, Chinese Academy of Medical Sciences, Beijing, China.
Zhao S; Department of Respiratory Medicine II, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
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Źródło :
Integrative zoology [Integr Zool] 2021 Mar; Vol. 16 (2), pp. 270-279. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
Asthma/*physiopathology
Epithelial Cells/*drug effects
Galectins/*metabolism
Animals ; Apoptosis ; Bronchi/cytology ; Bronchi/drug effects ; Bronchi/virology ; Cadherins/metabolism ; Disease Models, Animal ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Epithelial Cells/virology ; Galectins/genetics ; Mice, Transgenic ; Ovalbumin/pharmacology ; Rats, Sprague-Dawley ; Respiratory Syncytial Virus Infections ; Respiratory Syncytial Viruses ; Tight Junctions/metabolism
Czasopismo naukowe
Tytuł :
Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib.
Autorzy :
Du J; Center for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Li G; Center for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Jiang L; Center for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zhang X; Department of Medical Oncology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China.
Xu Z; Center for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Yan H; Center for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zhou Z; Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
He Q; Center for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Yang X; Center for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Luo P; Center for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Mar 01; Vol. 338, pp. 1-9. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article
MeSH Terms :
Alveolar Epithelial Cells/*drug effects
Antineoplastic Agents/*toxicity
Cell Communication/*drug effects
Fibroblasts/*drug effects
Gefitinib/*toxicity
Lung/*drug effects
Macrophages, Alveolar/*drug effects
Protein Kinase Inhibitors/*toxicity
Aged ; Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/pathology ; Animals ; Apoptosis/drug effects ; Cell Line ; Chemokine CCL2/genetics ; Chemokine CCL2/metabolism ; Coculture Techniques ; Epithelial-Mesenchymal Transition/drug effects ; Female ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Humans ; Lung/metabolism ; Lung/pathology ; Macrophages, Alveolar/metabolism ; Macrophages, Alveolar/pathology ; Male ; Mice ; Middle Aged ; STAT3 Transcription Factor/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells.
Autorzy :
Lamers MM; Viroscience Department, Erasmus University Medical Center, Rotterdam, The Netherlands.
van der Vaart J; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Utrecht, The Netherlands.
Knoops K; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, The Netherlands.
Riesebosch S; Viroscience Department, Erasmus University Medical Center, Rotterdam, The Netherlands.
Breugem TI; Viroscience Department, Erasmus University Medical Center, Rotterdam, The Netherlands.
Mykytyn AZ; Viroscience Department, Erasmus University Medical Center, Rotterdam, The Netherlands.
Beumer J; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Utrecht, The Netherlands.
Schipper D; Viroscience Department, Erasmus University Medical Center, Rotterdam, The Netherlands.
Bezstarosti K; Proteomics Center, Erasmus University Medical Center, Rotterdam, The Netherlands.
Koopman CD; Single Cell Discoveries, Utrecht, The Netherlands.
Groen N; Single Cell Discoveries, Utrecht, The Netherlands.
Ravelli RBG; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, The Netherlands.
Duimel HQ; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, The Netherlands.
Demmers JAA; Proteomics Center, Erasmus University Medical Center, Rotterdam, The Netherlands.
Verjans GMGM; Viroscience Department, Erasmus University Medical Center, Rotterdam, The Netherlands.
Koopmans MPG; Viroscience Department, Erasmus University Medical Center, Rotterdam, The Netherlands.
Muraro MJ; Single Cell Discoveries, Utrecht, The Netherlands.
Peters PJ; The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, The Netherlands.
Clevers H; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Utrecht, The Netherlands.
Haagmans BL; Viroscience Department, Erasmus University Medical Center, Rotterdam, The Netherlands.
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Źródło :
The EMBO journal [EMBO J] 2021 Mar 01; Vol. 40 (5), pp. e105912. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Biological*
Virus Replication*
Alveolar Epithelial Cells/*metabolism
COVID-19/*metabolism
Organoids/*metabolism
SARS-CoV-2/*physiology
Alveolar Epithelial Cells/pathology ; Alveolar Epithelial Cells/virology ; Animals ; COVID-19/virology ; Chlorocebus aethiops ; Gene Expression Regulation ; Humans ; Interferon Type I/biosynthesis ; Interferons/biosynthesis ; Organoids/pathology ; Organoids/virology ; Vero Cells
Czasopismo naukowe
Tytuł :
Effect of forkhead box O1 in renal tubular epithelial cells on endotoxin-induced acute kidney injury.
Autorzy :
Zhang M; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Dong W; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Li Z; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Xiao Z; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; School of Medicine, South China University of Technology, Guangzhou, China.
Xie Z; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Ye Z; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Liu S; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Li R; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Chen Y; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Zhang L; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Wang M; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; School of Medicine, South China University of Technology, Guangzhou, China.
Liang H; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Baihetiyaer R; Division of Nephrology, First People's Hospital of Kasha, Foshan, China.
Apaer R; Division of Nephrology, First People's Hospital of Kasha, Foshan, China.
Dong Z; Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia.; Department of Medical Research, Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia.
Liang X; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2021 Mar 01; Vol. 320 (3), pp. F262-F272. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acute Kidney Injury/*metabolism
Endotoxemia/*complications
Epithelial Cells/*metabolism
Forkhead Box Protein O1/*metabolism
Kidney Tubules/*metabolism
Acute Kidney Injury/etiology ; Acute Kidney Injury/genetics ; Acute Kidney Injury/pathology ; Animals ; Cell Line ; Disease Models, Animal ; Endotoxemia/chemically induced ; Epithelial Cells/ultrastructure ; Forkhead Box Protein O1/genetics ; Humans ; Kidney Tubules/ultrastructure ; Lipopolysaccharides ; Male ; Mice, Inbred C57BL ; Mitochondria/metabolism ; Mitochondria/ultrastructure ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Signal Transduction
Czasopismo naukowe

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