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Tytuł :
Production and Immunological Evaluation of Epitope-based Preventative Pneumococcal Candidate Vaccine Comprising Immunodominant Epitopes from PspA, CbpA, PhtD and PiuA Antigens.
Autorzy :
Dorosti H; Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Nezafat N; Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Heidari R; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Ghoshoon MB; Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Gholami A; Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Dehshahri A; Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Erfani N; Cancer Immunology Group, Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Rahbar MR; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Ghasemi Y; Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
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Źródło :
Current pharmaceutical biotechnology [Curr Pharm Biotechnol] 2021 Oct 06; Vol. 22 (14), pp. 1900-1909.
Typ publikacji :
Journal Article
MeSH Terms :
Immunodominant Epitopes*
Pneumococcal Vaccines*
Animals ; Bacterial Proteins ; Epitopes, T-Lymphocyte ; Mice ; Mice, Inbred BALB C
Czasopismo naukowe
Tytuł :
Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients.
Autorzy :
Wang X; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Lam JY; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Chen L; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Au SW; School of Life Sciences, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.
To KKW; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.; State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong SAR, People's Republic of China.; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Yuen KY; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.; State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong SAR, People's Republic of China.; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Kok KH; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.; State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong SAR, People's Republic of China.; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong SAR, People's Republic of China.; AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2021 Dec; Vol. 10 (1), pp. 1016-1023.
Typ publikacji :
Journal Article
MeSH Terms :
Epitopes, B-Lymphocyte*
COVID-19/*immunology
SARS-CoV-2/*immunology
Viral Proteins/*chemistry
Animals ; Antibodies, Viral ; Cricetinae ; Humans ; Immunodominant Epitopes ; Mesocricetus ; Models, Molecular ; Protein Conformation ; Viral Proteins/immunology
Czasopismo naukowe
Tytuł :
Identification of the Dominant T-Cell Epitopes of Lit v 1 Shrimp Major Allergen and Their Functional Overlap with Known B-Cell Epitopes.
Autorzy :
Xu LL; College of Food Science and Engineering, Ocean University of China, No.5, Yushan Road, Qingdao, Shandong Province 266003, P. R. China.
Gasset M; Institute of Physical Chemistry Rocasolano (IQFR), Spanish National Research Council (CSIC), 28006 Madrid, Spain.
Lin H; College of Food Science and Engineering, Ocean University of China, No.5, Yushan Road, Qingdao, Shandong Province 266003, P. R. China.
Yu C; College of Food Science and Engineering, Ocean University of China, No.5, Yushan Road, Qingdao, Shandong Province 266003, P. R. China.
Zhao JL; College of Food Science and Engineering, Ocean University of China, No.5, Yushan Road, Qingdao, Shandong Province 266003, P. R. China.
Dang XW; College of Food Science and Engineering, Ocean University of China, No.5, Yushan Road, Qingdao, Shandong Province 266003, P. R. China.
Li ZX; College of Food Science and Engineering, Ocean University of China, No.5, Yushan Road, Qingdao, Shandong Province 266003, P. R. China.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Jul 07; Vol. 69 (26), pp. 7420-7428. Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article
MeSH Terms :
Allergens*
Epitopes, B-Lymphocyte*
Amino Acid Sequence ; Epitopes, T-Lymphocyte ; Humans ; Tropomyosin
Czasopismo naukowe
Tytuł :
Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2.
Autorzy :
Low JS; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Vaqueirinho D; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Mele F; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Foglierini M; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Jerak J; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Perotti M; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Jarrossay D; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Jovic S; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Perez L; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
Cacciatore R; Laboratory of Immunogenetics, Department of Transfusion Medicine and Immuno-Hematology, Fondazione I.R.C.C.S. Policlinico S. Matteo, 27100 Pavia, Italy.
Terrot T; Clinical Trial Unit, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.
Pellanda AF; Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, 6900 Lugano, Switzerland.
Biggiogero M; Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, 6900 Lugano, Switzerland.
Garzoni C; Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, 6900 Lugano, Switzerland.
Ferrari P; Faculty of Biomedical Sciences, Università della Svizzera italiana, 6900 Lugano, Switzerland.; Department of Internal Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.; Prince of Wales Hospital Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia.
Ceschi A; Clinical Trial Unit, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera italiana, 6900 Lugano, Switzerland.; Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland.; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, 8091 Zurich, Switzerland.
Lanzavecchia A; National Institute of Molecular Genetics, 20122 Milano, Italy.
Sallusto F; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland. .; Institute of Microbiology, ETH Zürich, 8093 Zurich, Switzerland.
Cassotta A; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland. .
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jun 18; Vol. 372 (6548), pp. 1336-1341. Date of Electronic Publication: 2021 May 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunodominant Epitopes*
CD4-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Coronavirus/immunology ; Cross Reactions ; Epitopes, T-Lymphocyte/immunology ; Genes, T-Cell Receptor beta ; HLA-DP Antigens/immunology ; HLA-DR Antigens/immunology ; Humans ; Immunologic Memory ; Nucleocapsid Proteins/immunology ; Protein Domains ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Spike Glycoprotein, Coronavirus/chemistry ; T Follicular Helper Cells/immunology ; T-Lymphocyte Subsets/immunology
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
SARS-CoV-2 specific memory T cell epitopes identified in COVID-19-recovered subjects.
Autorzy :
Zhao J; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States; Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, ETSU, Johnson City, Tennessee 37614, United States.
Wang L; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States; Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, ETSU, Johnson City, Tennessee 37614, United States.
Schank M; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States; Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, ETSU, Johnson City, Tennessee 37614, United States.
Dang X; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States; Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, ETSU, Johnson City, Tennessee 37614, United States.
Lu Z; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States.
Cao D; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States; Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, ETSU, Johnson City, Tennessee 37614, United States.
Khanal S; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States; Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, ETSU, Johnson City, Tennessee 37614, United States.
Nguyen LN; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States; Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, ETSU, Johnson City, Tennessee 37614, United States.
Nguyen LNT; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States; Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, ETSU, Johnson City, Tennessee 37614, United States.
Zhang J; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States; Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, ETSU, Johnson City, Tennessee 37614, United States.
Zhang Y; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States; Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, ETSU, Johnson City, Tennessee 37614, United States.
Adkins JL; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States.
Baird EM; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States.
Wu XY; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States; Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, ETSU, Johnson City, Tennessee 37614, United States.
Ning S; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States; Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, ETSU, Johnson City, Tennessee 37614, United States.
Gazzar ME; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States; Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, ETSU, Johnson City, Tennessee 37614, United States.
Moorman JP; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States; Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, ETSU, Johnson City, Tennessee 37614, United States; Hepatitis (HCV/HBV/HIV) Program, James H. Quillen VA Medical Center, Department of Veterans Affairs, Johnson City, Tennessee 37614, United States.
Yao ZQ; Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, United States; Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, ETSU, Johnson City, Tennessee 37614, United States; Hepatitis (HCV/HBV/HIV) Program, James H. Quillen VA Medical Center, Department of Veterans Affairs, Johnson City, Tennessee 37614, United States. Electronic address: .
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Źródło :
Virus research [Virus Res] 2021 Oct 15; Vol. 304, pp. 198508. Date of Electronic Publication: 2021 Jul 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Pandemics*
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
Epitopes, T-Lymphocyte/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Adult ; CD8-Positive T-Lymphocytes/cytology ; COVID-19/epidemiology ; Female ; Humans ; Immunodominant Epitopes/immunology ; Male ; Middle Aged ; SARS-CoV-2/immunology ; Young Adult
Czasopismo naukowe
Tytuł :
Immunogenicity of Foot-and-Mouth Disease Virus Dendrimer Peptides: Need for a T-Cell Epitope and Ability to Elicit Heterotypic Responses.
Autorzy :
Cañas-Arranz R; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), 28049 Madrid, Spain.
de León P; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), 28049 Madrid, Spain.
Defaus S; Departament de Ciències Experimentals i de la Salut (DCEXS-UPF), 08003 Barcelona, Spain.
Torres E; Centro de Investigación en Sanidad Animal (CISA-INIA), 28130 Valdeolmos, Spain.
Forner M; Departament de Ciències Experimentals i de la Salut (DCEXS-UPF), 08003 Barcelona, Spain.
Bustos MJ; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), 28049 Madrid, Spain.
Andreu D; Departament de Ciències Experimentals i de la Salut (DCEXS-UPF), 08003 Barcelona, Spain.
Blanco E; Centro de Investigación en Sanidad Animal (CISA-INIA), 28130 Valdeolmos, Spain.
Sobrino F; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), 28049 Madrid, Spain.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 04; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 04.
Typ publikacji :
Journal Article
MeSH Terms :
Dendrimers/*chemistry
Epitopes, T-Lymphocyte/*immunology
Foot-and-Mouth Disease Virus/*immunology
Peptides/*immunology
Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Epitopes, B-Lymphocyte/immunology ; Female ; Foot-and-Mouth Disease/immunology ; Foot-and-Mouth Disease/virology ; Mice ; Species Specificity ; Swine
Czasopismo naukowe
Tytuł :
SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19.
Autorzy :
Grifoni A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Sidney J; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Vita R; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Peters B; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
Crotty S; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.
Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2021 Jul 14; Vol. 29 (7), pp. 1076-1092. Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Adaptive Immunity*
COVID-19/*immunology
Epitopes, T-Lymphocyte/*immunology
SARS-CoV-2/*immunology
Antigens, Viral ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cross Reactions ; Epitopes ; Humans ; Immunodominant Epitopes
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
Designing a multi-epitope vaccine candidate to combat MERS-CoV by employing an immunoinformatics approach.
Autorzy :
Mahmud S; Microbiology Laboratory, Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, 6505, Bangladesh.
Rafi MO; Department of Genetic Engineering and Biotechnology, Jashore University of Science and Technology, Jashore, 7408, Bangladesh.
Paul GK; Microbiology Laboratory, Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, 6505, Bangladesh.
Promi MM; Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, 6505, Bangladesh.
Shimu MSS; Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, 6505, Bangladesh.
Biswas S; Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, 6505, Bangladesh.
Emran TB; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, 4381, Bangladesh.
Dhama K; Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122, Uttar Pradesh, India.
Alyami SA; Department of Mathematics and Statistics, Imam Mohammad Ibn Saud Islamic University, Riyadh, 11432, Saudi Arabia.
Moni MA; Faculty of Medicine, WHO Collaborating Centre on eHealth, UNSW Digital Health, School of Public Health and Community Medicine, UNSW Sydney, Sydney, NSW, 2052, Australia. .
Saleh MA; Microbiology Laboratory, Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, 6505, Bangladesh. .
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Źródło :
Scientific reports [Sci Rep] 2021 Jul 29; Vol. 11 (1), pp. 15431. Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article
MeSH Terms :
Epitopes/*immunology
Middle East Respiratory Syndrome Coronavirus/*immunology
Vaccines/*immunology
Computational Biology ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Epitopes, B-Lymphocyte/genetics ; Epitopes, B-Lymphocyte/immunology ; Epitopes, T-Lymphocyte/genetics ; Epitopes, T-Lymphocyte/immunology ; Humans ; Immunogenicity, Vaccine/immunology ; Middle East Respiratory Syndrome Coronavirus/genetics ; Middle East Respiratory Syndrome Coronavirus/pathogenicity ; Models, Molecular ; Molecular Docking Simulation ; Phylogeny ; Protein Binding ; Spike Glycoprotein, Coronavirus/immunology ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Helper-Inducer/immunology ; Vaccines/pharmacology ; Vaccines, Subunit/immunology ; Viral Vaccines/immunology
Czasopismo naukowe
Tytuł :
Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern.
Autorzy :
Voss C; Department of Biochemistry and.
Esmail S; Department of Biochemistry and.
Liu X; Department of Biochemistry and.
Knauer MJ; Department of Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Ackloo S; Structural Genomics Consortium and.
Kaneko T; Department of Biochemistry and.
Lowes L; Department of Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Stogios P; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
Seitova A; Structural Genomics Consortium and.
Hutchinson A; Structural Genomics Consortium and.
Yusifov F; Structural Genomics Consortium and.
Skarina T; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
Evdokimova E; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
Loppnau P; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
Ghiabi P; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
Haijan T; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
Zhong S; Department of Biochemistry and.
Abdoh H; Department of Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Hedley BD; Department of Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Bhayana V; Department of Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Martin CM; Department of Medicine, Western University, London, Ontario, Canada.; London Health Sciences Centre, London, Ontario, Canada.
Slessarev M; Department of Medicine, Western University, London, Ontario, Canada.; London Health Sciences Centre, London, Ontario, Canada.
Chin-Yee B; Divison of Hematology and.
Fraser DD; Department of Medicine, Western University, London, Ontario, Canada.; London Health Sciences Centre, London, Ontario, Canada.; Department of Paediatrics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Chin-Yee I; Department of Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Li SS; Department of Biochemistry and.
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Źródło :
JCI insight [JCI Insight] 2021 Jul 08; Vol. 6 (13). Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article
MeSH Terms :
Agglutination Tests/*methods
Antibody Formation/*immunology
COVID-19/*immunology
COVID-19 Serological Testing/*methods
Epitopes, B-Lymphocyte/*immunology
SARS-CoV-2/*immunology
Amino Acid Sequence ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Antibody Specificity/immunology ; COVID-19/blood ; COVID-19/mortality ; Epitopes/immunology ; Epitopes, B-Lymphocyte/chemistry ; Epitopes, B-Lymphocyte/genetics ; Humans ; Immunity, Humoral ; Microarray Analysis/methods ; Nucleocapsid/chemistry ; Nucleocapsid/genetics ; Nucleocapsid/immunology ; Peptides/immunology ; SARS-CoV-2/genetics ; Severity of Illness Index ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
Immunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individuals.
Autorzy :
Mahajan S; MedGenome, Bangalore, India.
Kode V; MedGenome, Foster City, USA.
Bhojak K; MedGenome, Bangalore, India.
Karunakaran C; MedGenome, Bangalore, India.
Lee K; MedGenome, Foster City, USA.
Manoharan M; MedGenome, Bangalore, India.
Ramesh A; MedGenome, Bangalore, India.
Hv S; MedGenome, Bangalore, India.
Srivastava A; MedGenome, Bangalore, India.
Sathian R; MedGenome, Bangalore, India.
Khan T; MedGenome, Foster City, USA.
Kumar P; MedGenome, Bangalore, India.
Gupta R; MedGenome, Bangalore, India.
Chakraborty P; MedGenome, Foster City, USA. .
Chaudhuri A; MedGenome, Foster City, USA. .
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Źródło :
Scientific reports [Sci Rep] 2021 Jun 23; Vol. 11 (1), pp. 13164. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article
MeSH Terms :
Immunodominant Epitopes*
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
Epitopes, T-Lymphocyte/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Algorithms ; Clone Cells ; Gene Expression ; Humans ; Lymphocyte Activation ; Receptors, Antigen, T-Cell/immunology ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
CD8 T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses.
Autorzy :
Lineburg KE; QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Grant EJ; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
Swaminathan S; QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia; Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.
Chatzileontiadou DSM; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
Szeto C; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
Sloane H; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
Panikkar A; QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Raju J; QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Crooks P; QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Rehan S; QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Nguyen AT; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
Lekieffre L; QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Neller MA; QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Tong ZWM; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Jayasinghe D; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
Chew KY; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Lobos CA; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
Halim H; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Burrows JM; QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Riboldi-Tunnicliffe A; Australian Synchrotron, ANSTO, Clayton, VIC 3168, Australia.
Chen W; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
D'Orsogna L; Department of Clinical Immunology, PathWest Laboratory Medicine, Fiona Stanley Hospital, Murdoch, WA 6150, Australia; School of Medicine, University of Western Australia, Nedlands, WA 6009, Australia.
Khanna R; QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Short KR; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD 4072, Australia.
Smith C; QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Department of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia; Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: .
Gras S; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia. Electronic address: .
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Źródło :
Immunity [Immunity] 2021 May 11; Vol. 54 (5), pp. 1055-1065.e5. Date of Electronic Publication: 2021 Apr 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
Coronavirus Nucleocapsid Proteins/*immunology
Immunodominant Epitopes/*immunology
SARS-CoV-2/*immunology
Amino Acid Sequence ; Coronavirus/classification ; Coronavirus/immunology ; Coronavirus Nucleocapsid Proteins/chemistry ; Cross Reactions ; Epitopes, T-Lymphocyte/chemistry ; Epitopes, T-Lymphocyte/immunology ; HLA-B7 Antigen/chemistry ; HLA-B7 Antigen/genetics ; HLA-B7 Antigen/immunology ; Humans ; Immunodominant Epitopes/chemistry ; Immunologic Memory ; Models, Molecular ; Peptides/chemistry ; Peptides/immunology ; Receptors, Antigen, T-Cell/chemistry ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/immunology
Czasopismo naukowe
Tytuł :
CD8 T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity.
Autorzy :
Nguyen THO; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Rowntree LC; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Petersen J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia.
Chua BY; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia; Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo 060-0808, Japan.
Hensen L; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Kedzierski L; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia; Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, VIC 3000, Australia.
van de Sandt CE; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam 1066CX, the Netherlands.
Chaurasia P; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Tan HX; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Habel JR; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Zhang W; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Allen LF; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Earnest L; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Mak KY; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Juno JA; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Wragg K; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Mordant FL; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Amanat F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Mifsud NA; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Doolan DL; Centre for Molecular Therapeutics, Australian Institute of Tropical Health & Medicine, James Cook University, Cairns, QLD 4870, Australia.
Flanagan KL; School of Health Sciences and School of Medicine, University of Tasmania, Launceston, TAS 7248, Australia; Department of Immunology and Pathology, Monash University, Commercial Road, Melbourne, VIC 3004, Australia; School of Health and Biomedical Science, RMIT University, Melbourne, VIC 3000, Australia; Tasmanian Vaccine Trial Centre, Clifford Craig Foundation, Launceston General Hospital, Launceston, TAS 7250, Australia.
Sonda S; School of Health Sciences and School of Medicine, University of Tasmania, Launceston, TAS 7248, Australia.
Kaur J; School of Health Sciences and School of Medicine, University of Tasmania, Launceston, TAS 7248, Australia; Tasmanian Vaccine Trial Centre, Clifford Craig Foundation, Launceston General Hospital, Launceston, TAS 7250, Australia.
Wakim LM; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Westall GP; Lung Transplant Unit, Alfred Hospital, Melbourne, VIC 3004, Australia.
James F; Department of Infectious Diseases, Austin Hospital, Heidelberg, VIC 3084, Australia.
Mouhtouris E; Department of Infectious Diseases, Austin Hospital, Heidelberg, VIC 3084, Australia.
Gordon CL; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia; Department of Infectious Diseases, Austin Hospital, Heidelberg, VIC 3084, Australia.
Holmes NE; Department of Infectious Diseases, Austin Hospital, Heidelberg, VIC 3084, Australia; Department of Medicine and Radiology, The University of Melbourne, Parkville, VIC 3000, Australia; Data Analytics Research and Evaluation (DARE) Centre, Austin Health and The University of Melbourne, Heidelberg, VIC 3084, Australia.
Smibert OC; Department of Infectious Diseases, Austin Hospital, Heidelberg, VIC 3084, Australia; Department of Infectious Diseases, Peter McCallum Cancer Centre, Melbourne, VIC 3000, Australia; The National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC 3000, Australia.
Trubiano JA; Department of Infectious Diseases, Peter McCallum Cancer Centre, Melbourne, VIC 3000, Australia; The National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC 3000, Australia; Centre for Antibiotic Allergy and Research, Department of Infectious Diseases Austin Health, Heidelberg, VIC 3084, Australia; Department of Medicine (Austin Health), The University of Melbourne, Heidelberg, VIC 3084, Australia.
Cheng AC; Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, VIC 3004, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Harcourt P; AFL House, Melbourne, VIC 3001, Australia.
Clifton P; AFL House, Melbourne, VIC 3001, Australia.
Crawford JC; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Thomas PG; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Wheatley AK; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Melbourne, VIC 3000, Australia.
Kent SJ; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Melbourne, VIC 3000, Australia; Melbourne Sexual Health Centre, Infectious Diseases Department, Alfred Health, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Rossjohn J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Australian Research Council Centre of Excellence for Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia; Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom.
Torresi J; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
Kedzierska K; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia; Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo 060-0808, Japan. Electronic address: .
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Źródło :
Immunity [Immunity] 2021 May 11; Vol. 54 (5), pp. 1066-1082.e5. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
Coronavirus Nucleocapsid Proteins/*immunology
Immunodominant Epitopes/*immunology
Receptors, Antigen, T-Cell/*immunology
SARS-CoV-2/*immunology
Adult ; Aged ; Amino Acid Motifs ; CD4-Positive T-Lymphocytes ; Child ; Convalescence ; Coronavirus Nucleocapsid Proteins/chemistry ; Epitopes, T-Lymphocyte/chemistry ; Epitopes, T-Lymphocyte/immunology ; Female ; Humans ; Immunodominant Epitopes/chemistry ; Male ; Middle Aged ; Phenotype ; Phosphoproteins/chemistry ; Phosphoproteins/immunology ; Receptors, Antigen, T-Cell/chemistry ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell, alpha-beta/chemistry ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/immunology
Czasopismo naukowe
Tytuł :
Identification and characterization of a SARS-CoV-2 specific CD8 T cell response with immunodominant features.
Autorzy :
Gangaev A; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, North Holland, The Netherlands.
Ketelaars SLC; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, North Holland, The Netherlands.
Isaeva OI; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, North Holland, The Netherlands.
Patiwael S; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, North Holland, The Netherlands.
Dopler A; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, North Holland, The Netherlands.
Hoefakker K; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, North Holland, The Netherlands.
De Biasi S; University of Modena and Reggio Emilia School of Medicine, Modena, Emilia Romagna, Italy.
Gibellini L; University of Modena and Reggio Emilia School of Medicine, Modena, Emilia Romagna, Italy.
Mussini C; University of Modena and Reggio Emilia School of Medicine, Modena, Emilia Romagna, Italy.
Guaraldi G; University of Modena and Reggio Emilia School of Medicine, Modena, Emilia Romagna, Italy.
Girardis M; University of Modena and Reggio Emilia School of Medicine, Modena, Emilia Romagna, Italy.
Ormeno CMPT; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, South Holland, The Netherlands.
Hekking PJM; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, South Holland, The Netherlands.
Lardy NM; Department of Immunogenetics, Sanquin Diagnostics B.V., Amsterdam, North Holland, The Netherlands.
Toebes M; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, North Holland, The Netherlands.
Balderas R; Department of Biological Sciences, BD Biosciences, San Jose, CA, USA.
Schumacher TN; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, North Holland, The Netherlands.
Ovaa H; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, South Holland, The Netherlands.
Cossarizza A; University of Modena and Reggio Emilia School of Medicine, Modena, Emilia Romagna, Italy.
Kvistborg P; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, North Holland, The Netherlands. .
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Źródło :
Nature communications [Nat Commun] 2021 May 10; Vol. 12 (1), pp. 2593. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
COVID-19/*immunology
Immunodominant Epitopes/*immunology
SARS-CoV-2/*immunology
Adult ; Aged ; Aged, 80 and over ; Alleles ; CD8-Positive T-Lymphocytes/pathology ; COVID-19/pathology ; Epitopes, T-Lymphocyte/immunology ; Female ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/immunology ; Humans ; Immunodominant Epitopes/chemistry ; Immunologic Memory ; Lymphocyte Activation ; Male ; Middle Aged ; Polyproteins/immunology ; Viral Proteins/immunology
Czasopismo naukowe
Tytuł :
Immunoinformatics designed T cell multi epitope dengue peptide vaccine derived from non structural proteome.
Autorzy :
Krishnan G S; Domain of Bioinformatics, School of Bio-Engineering and Bio-Sciences, Lovely Professional University, Punjab, India. Electronic address: .
Joshi A; Domain of Bioinformatics, School of Bio-Engineering and Bio-Sciences, Lovely Professional University, Punjab, India. Electronic address: .
Akhtar N; Domain of Bioinformatics, School of Bio-Engineering and Bio-Sciences, Lovely Professional University, Punjab, India. Electronic address: .
Kaushik V; Domain of Bioinformatics, School of Bio-Engineering and Bio-Sciences, Lovely Professional University, Punjab, India. Electronic address: .
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Źródło :
Microbial pathogenesis [Microb Pathog] 2021 Jan; Vol. 150, pp. 104728. Date of Electronic Publication: 2021 Jan 02.
Typ publikacji :
Journal Article
MeSH Terms :
Dengue*/prevention & control
Epitopes, T-Lymphocyte*
Animals ; Computational Biology ; Epitopes, B-Lymphocyte ; Humans ; Molecular Docking Simulation ; Mosquito Vectors ; Peptides ; Proteome ; T-Lymphocytes ; Vaccines, Subunit
Czasopismo naukowe
Tytuł :
Exploring membrane proteins of Leishmania major to design a new multi-epitope vaccine using immunoinformatics approach.
Autorzy :
Rabienia M; Department of Medical Biotechnology, Fasa University of Medical Sciences, Fasa, Iran.
Roudbari Z; Department of Animal Science, Faculty of Agriculture, University of Jiroft, Jiroft, Iran.
Ghanbariasad A; Department of Medical Biotechnology, Fasa University of Medical Sciences, Fasa, Iran.
Abdollahi A; Department of Medical Microbiology, Fasa University of Medical Sciences, Fasa, Iran.
Mohammadi E; Department of Animal Science, Ferdowsi University of Mashhad, Mashhad, Iran.
Mortazavidehkordi N; Department of Medical Parasitology, Fasa University of Medical Sciences, Fasa, Iran. Electronic address: .
Farjadfar A; Department of Medical Biotechnology, Fasa University of Medical Sciences, Fasa, Iran. Electronic address: .
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2020 Sep 01; Vol. 152, pp. 105423. Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
Epitopes, T-Lymphocyte*
Leishmania major*
Computational Biology ; Epitopes, B-Lymphocyte ; Membrane Proteins ; Molecular Docking Simulation ; Vaccines, Subunit
Czasopismo naukowe
Tytuł :
Identification of Unique Peptides for SARS-CoV-2 Diagnostics and Vaccine Development by an In Silico Proteomics Approach.
Autorzy :
Kesarwani V; DBT-National Institute of Animal Biotechnology (NIAB), Hyderabad, India.
Gupta R; DBT-National Institute of Animal Biotechnology (NIAB), Hyderabad, India.; Amity Institute of Biotechnology, Amity University, Mumbai, India.
Vetukuri RR; Department of Plant Breeding, Swedish University of Agricultural Sciences, Alnarp, Sweden.
Kushwaha SK; DBT-National Institute of Animal Biotechnology (NIAB), Hyderabad, India.
Gandhi S; DBT-National Institute of Animal Biotechnology (NIAB), Hyderabad, India.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Sep 24; Vol. 12, pp. 725240. Date of Electronic Publication: 2021 Sep 24 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*diagnosis
COVID-19 Vaccines/*immunology
Coronavirus Nucleocapsid Proteins/*metabolism
Epitopes, B-Lymphocyte/*metabolism
Epitopes, T-Lymphocyte/*metabolism
Peptides/*metabolism
Pulmonary Alveoli/*pathology
SARS-CoV-2/*physiology
Spike Glycoprotein, Coronavirus/*metabolism
A549 Cells ; COVID-19/immunology ; Cell Line ; Coronavirus Nucleocapsid Proteins/genetics ; Epitope Mapping ; Epitopes, B-Lymphocyte/genetics ; Epitopes, T-Lymphocyte/genetics ; HLA Antigens/metabolism ; Humans ; Molecular Docking Simulation ; Peptides/genetics ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Protein Binding ; Proteomics ; Receptors, Antigen/metabolism ; Spike Glycoprotein, Coronavirus/genetics
Czasopismo naukowe
Tytuł :
COVID-19 coronavirus vaccine T cell epitope prediction analysis based on distributions of HLA class I loci (HLA-A, -B, -C) across global populations.
Autorzy :
Cun Y; Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Yunnan Engineering Research Centre of Vaccine Research & Development on Severe Infectious Diseases, Kunming, China.
Li C; Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Yunnan Engineering Research Centre of Vaccine Research & Development on Severe Infectious Diseases, Kunming, China.
Shi L; Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Yunnan Engineering Research Centre of Vaccine Research & Development on Severe Infectious Diseases, Kunming, China.
Sun M; Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Yunnan Engineering Research Centre of Vaccine Research & Development on Severe Infectious Diseases, Kunming, China.
Dai S; School of Basic Medical Science, Kunming Medical University, Kunming, China.
Sun L; School of Basic Medical Science, Kunming Medical University, Kunming, China.
Shi L; Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Yunnan Engineering Research Centre of Vaccine Research & Development on Severe Infectious Diseases, Kunming, China.
Yao Y; Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Diseases, Yunnan Engineering Research Centre of Vaccine Research & Development on Severe Infectious Diseases, Kunming, China.
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Źródło :
Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2021 Apr 03; Vol. 17 (4), pp. 1097-1108. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19 Vaccines/*immunology
Coronavirus Nucleocapsid Proteins/*immunology
Epitopes, T-Lymphocyte/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; COVID-19/immunology ; COVID-19/prevention & control ; Epitopes, B-Lymphocyte/immunology ; HLA-A Antigens/immunology ; HLA-B Antigens/immunology ; HLA-C Antigens/immunology ; Humans ; Immunogenicity, Vaccine/immunology ; Phosphoproteins/immunology
Czasopismo naukowe
Tytuł :
Identification of immunodominant proteins of Leishmania infantum by immunoproteomics to evaluate a recombinant multi-epitope designed antigen for serodiagnosis of human visceral leishmaniasis.
Autorzy :
Heidari S; Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Hajjaran H; Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: .
Kazemi B; Department of Biotechnology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gharechahi J; Human Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Mohebali M; Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Center for Research of Endemic Parasites of Iran, Tehran University of Medical Sciences, Tehran, Iran.
Ranjbar MM; Razi Vaccine and Serum Research Institute, Karaj, Iran.
Akhoundi B; Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Azarian B; Protein Chemistry Unit, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Mirshahvaladi S; Department of Molecular Systems Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Raoofian R; Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.
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Źródło :
Experimental parasitology [Exp Parasitol] 2021 Mar; Vol. 222, pp. 108065. Date of Electronic Publication: 2021 Jan 09.
Typ publikacji :
Journal Article
MeSH Terms :
Immunodominant Epitopes/*isolation & purification
Leishmania infantum/*immunology
Leishmaniasis, Visceral/*diagnosis
Proteomics/*methods
Amino Acid Sequence ; Antigens, Protozoan/isolation & purification ; Blotting, Western ; Computational Biology/methods ; Electrophoresis, Gel, Two-Dimensional ; Enzyme-Linked Immunosorbent Assay ; Epitopes/immunology ; Epitopes/isolation & purification ; Humans ; Immunoblotting ; Leishmaniasis, Visceral/immunology ; Molecular Conformation ; Protein Structure, Secondary ; Proteomics/standards ; Protozoan Proteins/isolation & purification ; Recombinant Proteins/chemistry ; Recombinant Proteins/immunology ; Serologic Tests/methods ; Serologic Tests/standards ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Czasopismo naukowe
Tytuł :
Identification of the mimotopes within the major capsid protein L1 of human papillomavirus types 18 and 45, using neutralizing monoclonal antibodies.
Autorzy :
Li N; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Zhang G; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Chen Y; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China; Henan Zhongze Biological Engineering Co., Ltd., Zhengzhou 450002, China.
Zhou J; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China; Henan Zhongze Biological Engineering Co., Ltd., Zhengzhou 450002, China.
Hui C; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China; Henan Zhongze Biological Engineering Co., Ltd., Zhengzhou 450002, China.
Li S; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China; Henan Zhongze Biological Engineering Co., Ltd., Zhengzhou 450002, China.
Liu H; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China; Henan Zhongze Biological Engineering Co., Ltd., Zhengzhou 450002, China.
Liu Y; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China; Henan Zhongze Biological Engineering Co., Ltd., Zhengzhou 450002, China.
Qi Y; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Wang A; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Mar 31; Vol. 174, pp. 587-595. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article
MeSH Terms :
Alphapapillomavirus/*immunology
Antibodies, Neutralizing/*analysis
Capsid Proteins/*administration & dosage
Epitopes/*immunology
Animals ; Antibodies, Monoclonal/analysis ; Capsid Proteins/chemistry ; Capsid Proteins/immunology ; Cell Line ; Epitopes, B-Lymphocyte/immunology ; Female ; HEK293 Cells ; Human papillomavirus 18/immunology ; Humans ; Immunization ; Molecular Mimicry ; Neutralization Tests ; Peptide Library
Czasopismo naukowe
Tytuł :
Immuno-informatics design of a multimeric epitope peptide based vaccine targeting SARS-CoV-2 spike glycoprotein.
Autorzy :
Chukwudozie OS; Department of Cell Biology and Genetics, University of Lagos, Lagos, Nigeria.
Gray CM; Division of Immunology, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, University of Cape Town, Cape Town, South Africa.
Fagbayi TA; Department of Cell Biology and Genetics, University of Lagos, Lagos, Nigeria.
Chukwuanukwu RC; Immunology Unit, Medical Laboratory Science Department, Nnamdi Azikiwe University, Nnewi, Nigeria.
Oyebanji VO; Department of Veterinary Pathology, University of Ibadan, Ibadan, Nigeria.
Bankole TT; Department of Cell Biology and Genetics, University of Lagos, Lagos, Nigeria.
Adewole RA; Department of Cell Biology and Genetics, University of Lagos, Lagos, Nigeria.
Daniel EM; Public Health Biotechnology Unit, Institute of Child Health, University College Hospital, University of Ibadan, Ibadan, Nigeria.
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Źródło :
PloS one [PLoS One] 2021 Mar 17; Vol. 16 (3), pp. e0248061. Date of Electronic Publication: 2021 Mar 17 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*immunology
COVID-19 Vaccines/*immunology
Epitopes, T-Lymphocyte/*immunology
Immunogenicity, Vaccine/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Vaccines, Subunit/*immunology
CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Computational Biology/methods ; Cytokines/immunology ; Epitopes, B-Lymphocyte/immunology ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class II/immunology ; Humans ; Immunity, Cellular/immunology ; Immunoglobulin G/immunology ; Immunoglobulin M/immunology ; Molecular Docking Simulation ; Peptides/immunology
Czasopismo naukowe

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