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Wyszukujesz frazę ""ESTROGEN-RECEPTOR-ALPHA"" wg kryterium: Temat


Tytuł :
Oestrogen receptor alpha in papillary thyroid carcinoma: association with clinical features and BRAFV600E mutation.
Autorzy :
Liu S; Department of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Jiao B; Department of Anesthesiology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Li S; Department of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Zhao L; Department of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Zheng W; Department of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Wang K; Department of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Xu J; Department of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Tian Y; Department of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Liu C; Department of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Gui Z; Department of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Zhang L; Department of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
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Źródło :
Japanese journal of clinical oncology [Jpn J Clin Oncol] 2021 Jul 01; Vol. 51 (7), pp. 1051-1058.
Typ publikacji :
Journal Article
MeSH Terms :
Estrogen Receptor alpha*/genetics
Estrogen Receptor alpha*/metabolism
Proto-Oncogene Proteins B-raf*/genetics
Proto-Oncogene Proteins B-raf*/metabolism
Thyroid Cancer, Papillary*/genetics
Thyroid Cancer, Papillary*/metabolism
Thyroid Neoplasms*/genetics
Thyroid Neoplasms*/metabolism
Female ; Humans ; Male ; Middle Aged ; Mutation
Czasopismo naukowe
Tytuł :
ERα-agonist and ERβ-antagonist bifunctional next-generation bisphenols with no halogens: BPAP, BPB, and BPZ.
Autorzy :
Liu X; Department of Chemistry, Faculty of Science, Kyushu University, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan; Department of Applied Microbial Technology, Faculty of Biotechnology and Life Sciences, Sojo University, Kumamoto, 860-0082, Japan. Electronic address: .
Matsuyama Y; Department of Chemistry, Faculty of Science, Kyushu University, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan.
Shimohigashi M; Division of Biology, Department of Earth System of Science, Faculty of Science, Fukuoka University, Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan; Risk Science Research Institute, Ikimatsudai 3-7-5, Nishi-ku, Fukuoka, 819-0044, Japan.
Shimohigashi Y; Department of Chemistry, Faculty of Science, Kyushu University, Motooka 744, Nishi-ku, Fukuoka, 819-0395, Japan; Risk Science Research Institute, Ikimatsudai 3-7-5, Nishi-ku, Fukuoka, 819-0044, Japan. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Jul 01; Vol. 345, pp. 24-33. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Benzhydryl Compounds/*toxicity
Cyclohexanes/*toxicity
Endocrine Disruptors/*toxicity
Estrogen Antagonists/*toxicity
Estrogen Receptor alpha/*agonists
Estrogen Receptor beta/*antagonists & inhibitors
Estrogens/*toxicity
Phenols/*toxicity
Benzhydryl Compounds/chemistry ; Benzhydryl Compounds/metabolism ; Binding Sites ; Cyclohexanes/chemistry ; Cyclohexanes/metabolism ; Endocrine Disruptors/chemistry ; Endocrine Disruptors/metabolism ; Estrogen Antagonists/chemistry ; Estrogen Antagonists/metabolism ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/genetics ; Estrogen Receptor beta/metabolism ; Estrogens/chemistry ; Estrogens/metabolism ; HeLa Cells ; Humans ; Molecular Structure ; Phenols/chemistry ; Phenols/metabolism ; Protein Binding ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Heterodimeric GW7604 Derivatives: Modification of the Pharmacological Profile by Additional Interactions at the Coactivator Binding Site.
Autorzy :
Knox AK; Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI - Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Center for Chemistry and Biomedicine, 6020 Innsbruck, Austria.
Kalchschmid C; Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI - Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Center for Chemistry and Biomedicine, 6020 Innsbruck, Austria.
Schuster D; Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI - Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Center for Chemistry and Biomedicine, 6020 Innsbruck, Austria.; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Paracelsus Medical University, 5020 Salzburg, Austria.
Gaggia F; Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI - Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Center for Chemistry and Biomedicine, 6020 Innsbruck, Austria.
Gust R; Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI - Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Center for Chemistry and Biomedicine, 6020 Innsbruck, Austria.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 5766-5786. Date of Electronic Publication: 2021 Apr 27.
Typ publikacji :
Journal Article
MeSH Terms :
Acrylates/*chemistry
Estrogen Receptor alpha/*agonists
Tamoxifen/*analogs & derivatives
Acrylates/metabolism ; Acrylates/pharmacology ; Benzimidazoles/chemistry ; Benzimidazoles/metabolism ; Benzimidazoles/pharmacology ; Binding Sites ; Binding, Competitive ; Dimerization ; Down-Regulation/drug effects ; Estradiol/pharmacology ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Humans ; Ligands ; MCF-7 Cells ; Molecular Docking Simulation ; Quinazolinones/chemistry ; Quinazolinones/metabolism ; Quinazolinones/pharmacology ; Structure-Activity Relationship ; Tamoxifen/chemistry ; Tamoxifen/metabolism ; Tamoxifen/pharmacology ; Transcriptional Activation/drug effects
Czasopismo naukowe
Tytuł :
Expression of estrogen receptor alpha in response to stress and estrogen antagonist tamoxifen in the shell gland of Gallus gallus domesticus : involvement of anti-oxidant system and estrogen.
Autorzy :
Niranjan MK; Department of Zoology, Dr H. S. Gour Vishwavidyalaya, Sagar, India.
Koiri RK; Department of Zoology, Dr H. S. Gour Vishwavidyalaya, Sagar, India.
Srivastava R; Department of Zoology, Dr H. S. Gour Vishwavidyalaya, Sagar, India.
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Źródło :
Stress (Amsterdam, Netherlands) [Stress] 2021 May; Vol. 24 (3), pp. 261-272. Date of Electronic Publication: 2020 Jan 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chickens*
Estrogen Receptor alpha*/genetics
Animals ; Antioxidants ; Estradiol ; Estrogens ; Female ; Stress, Psychological ; Tamoxifen/pharmacology
Czasopismo naukowe
Tytuł :
Prenatal polycyclic aromatic hydrocarbons, altered ERα pathway-related methylation and expression, and mammary epithelial cell proliferation in offspring and grandoffspring adult mice.
Autorzy :
Sahay D; Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, United States; Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York City, NY, United States.
Lloyd SE; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City, NY, United States.
Rivera JA; Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, United States; Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York City, NY, United States.
Jezioro J; Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, United States; Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York City, NY, United States.
McDonald JD; Department of Toxicology, Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
Pitiranggon M; Lamont-Doherty Earth Observatory, Columbia University, Palisades, NY, United States.
Yan B; Lamont-Doherty Earth Observatory, Columbia University, Palisades, NY, United States.
Szabolcs M; Department of Pathology, College of Physicians and Surgeons, Columbia University, New York City, NY, United States.
Terry MB; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City, NY, United States; Herbert Irving Comprehensive Cancer Center, Columbia University, New York City, NY, United States.
Miller RL; Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, United States; Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York City, NY, United States; Herbert Irving Comprehensive Cancer Center, Columbia University, New York City, NY, United States. Electronic address: .
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Źródło :
Environmental research [Environ Res] 2021 May; Vol. 196, pp. 110961. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Estrogen Receptor alpha*/genetics
Estrogen Receptor alpha*/metabolism
Polycyclic Aromatic Hydrocarbons*/toxicity
Animals ; Cell Proliferation ; DNA Methylation ; Epigenesis, Genetic ; Female ; Mice ; Pregnancy ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism
Czasopismo naukowe
Tytuł :
Absence of estrogen receptors delays myoregeneration and leads to intermuscular adipogenesis in a low estrogen status: Morphological comparisons in estrogen receptor alpha and beta knock out mice.
Autorzy :
Chaiyasing R; Laboratory of Basic Veterinary Science, United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan.; Faculty of Veterinary Sciences, Office of Academic Affairs, Maha Sarakham University, Maha Sarakham 44000, Thailand.
Ishikawa T; Laboratory of Basic Veterinary Science, United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan.
Warita K; Laboratory of Basic Veterinary Science, United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan.; Department of Veterinary Anatomy, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
Hosaka YZ; Laboratory of Basic Veterinary Science, United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan.; Department of Veterinary Anatomy, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
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Źródło :
The Journal of veterinary medical science [J Vet Med Sci] 2021 Jul 02; Vol. 83 (7), pp. 1022-1030. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article
MeSH Terms :
Estrogen Receptor alpha*/genetics
Receptors, Estrogen*
Adipogenesis ; Animals ; Estradiol ; Estrogen Receptor beta/genetics ; Estrogens ; Female ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Ovariectomy/veterinary
Czasopismo naukowe
Tytuł :
Bisphenol A induces ovarian cancer cell proliferation and metastasis through estrogen receptor-α pathways.
Autorzy :
Sang C; School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.
Song Y; Department of Orthopedic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, Heilongjiang Province, China.
Jin TW; School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.
Zhang S; Department of Obstetrics & Gynecology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, 100730, China.
Fu L; Department of Obstetrics & Gynecology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, 100730, China.
Zhao Y; Department of Obstetrics & Gynecology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, 100730, China.
Zou X; Department of Obstetrics & Gynecology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, 100730, China.
Wang Z; School of Public Health, Xinxiang Medical University, Xinxiang, 453003, Henan Province, China. .
Gao H; Department of Obstetrics & Gynecology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, 100730, China. .
Liu S; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environment Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Jul; Vol. 28 (27), pp. 36060-36068. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article
MeSH Terms :
Estrogen Receptor alpha*
Ovarian Neoplasms*
Apoptosis ; Benzhydryl Compounds/toxicity ; Cell Line, Tumor ; Cell Proliferation ; Endothelial Cells ; Female ; Humans ; Matrix Metalloproteinase 2 ; Phenols ; Receptors, Estrogen
Czasopismo naukowe
Tytuł :
Molecular mechanism study of BPAF-induced proliferation of ERα-negative SKBR-3 human breast cancer cells in vitro/in vivo.
Autorzy :
Lei B; Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China. Electronic address: .
Xu L; Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
Tang Q; Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
Sun S; Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
Yu M; Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
Huang Y; Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
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Źródło :
The Science of the total environment [Sci Total Environ] 2021 Jun 25; Vol. 775, pp. 145814. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*
Estrogen Receptor alpha*/genetics
Animals ; Benzhydryl Compounds ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Phenols
Czasopismo naukowe
Tytuł :
Dynamics-Based Discovery of Novel, Potent Benzoic Acid Derivatives as Orally Bioavailable Selective Estrogen Receptor Degraders for ERα+ Breast Cancer.
Autorzy :
Zhang X; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.; R&D Center, Nanjing Sanhome Pharmaceutical Company Ltd., Nanjing 211135, China.
Wang Y; R&D Center, Nanjing Sanhome Pharmaceutical Company Ltd., Nanjing 211135, China.
Li X; R&D Center, Nanjing Sanhome Pharmaceutical Company Ltd., Nanjing 211135, China.
Wu J; R&D Center, Nanjing Sanhome Pharmaceutical Company Ltd., Nanjing 211135, China.
Zhao L; R&D Center, Nanjing Sanhome Pharmaceutical Company Ltd., Nanjing 211135, China.
Li W; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Liu J; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jun 10; Vol. 64 (11), pp. 7575-7595. Date of Electronic Publication: 2021 May 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemistry
Benzoic Acid/*chemistry
Estrogen Receptor alpha/*metabolism
Administration, Oral ; Animals ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Benzoic Acid/metabolism ; Benzoic Acid/pharmacology ; Benzoic Acid/therapeutic use ; Binding Sites ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Down-Regulation/drug effects ; Drug Design ; Estrogen Receptor alpha/chemistry ; Female ; Half-Life ; Humans ; Ligands ; MCF-7 Cells ; Mice ; Molecular Dynamics Simulation ; Structure-Activity Relationship ; Thermodynamics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Altered Expression of ESR1 , ESR2 , PELP1 and c-SRC Genes Is Associated with Ovarian Cancer Manifestation.
Autorzy :
Englert-Golon M; Surgical Gynecology Clinic of the Gynecological and Obstetrics Clinical Hospital, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland.
Andrusiewicz M; Chair and Department of Cell Biology, Faculty of Health Sciences, Poznan University of Medical Sciences, Rokietnicka 5D, 60-806 Poznan, Poland.
Żbikowska A; Chair and Department of Cell Biology, Faculty of Health Sciences, Poznan University of Medical Sciences, Rokietnicka 5D, 60-806 Poznan, Poland.
Chmielewska M; Chair and Department of Cell Biology, Faculty of Health Sciences, Poznan University of Medical Sciences, Rokietnicka 5D, 60-806 Poznan, Poland.
Sajdak S; Surgical Gynecology Clinic of the Gynecological and Obstetrics Clinical Hospital, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland.
Kotwicka M; Chair and Department of Cell Biology, Faculty of Health Sciences, Poznan University of Medical Sciences, Rokietnicka 5D, 60-806 Poznan, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 09; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 09.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
CSK Tyrosine-Protein Kinase/*biosynthesis
Co-Repressor Proteins/*biosynthesis
Estrogen Receptor alpha/*biosynthesis
Estrogen Receptor beta/*biosynthesis
Neoplasm Proteins/*biosynthesis
Ovarian Neoplasms/*metabolism
Transcription Factors/*biosynthesis
Adult ; Aged ; CSK Tyrosine-Protein Kinase/genetics ; Co-Repressor Proteins/genetics ; Estrogen Receptor alpha/genetics ; Estrogen Receptor beta/genetics ; Female ; Humans ; Middle Aged ; Neoplasm Proteins/genetics ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Estrogen receptors and their roles in the immune and respiratory systems.
Autorzy :
Millas I; UNINOVE Curso de Medicina Ringgold Standard Institution-Medical School, Sao Paulo, Brazil.
Duarte Barros M; FCMSCSP Ringgold Standard Institution-Morphology, São Paulo, Brazil.
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Źródło :
Anatomical record (Hoboken, N.J. : 2007) [Anat Rec (Hoboken)] 2021 Jun; Vol. 304 (6), pp. 1185-1193. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
COVID-19/*immunology
Estrogen Receptor alpha/*immunology
Estrogen Receptor beta/*immunology
Immune System/*immunology
Respiratory System/*immunology
SARS-CoV-2/*immunology
Animals ; COVID-19/metabolism ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/metabolism ; Humans ; Immune System/metabolism ; Nasal Mucosa/immunology ; Nasal Mucosa/metabolism ; Respiratory System/metabolism ; SARS-CoV-2/metabolism
Czasopismo naukowe
Tytuł :
Twist activates miR-22 to suppress estrogen receptor alpha in breast cancer.
Autorzy :
Vesuna F; Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. .
Lisok A; Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
van Diest P; Department of Pathology, University of Utrecht, Utrecht, The Netherlands.
Raman V; Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. .; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Jun; Vol. 476 (6), pp. 2295-2306. Date of Electronic Publication: 2021 Feb 13.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*metabolism
Estrogen Receptor alpha/*metabolism
MicroRNAs/*metabolism
Neoplasm Proteins/*metabolism
Nuclear Proteins/*metabolism
RNA, Neoplasm/*metabolism
Twist-Related Protein 1/*metabolism
Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Estrogen Receptor alpha/genetics ; Female ; Humans ; MCF-7 Cells ; MicroRNAs/genetics ; Neoplasm Proteins/genetics ; Nuclear Proteins/genetics ; RNA, Neoplasm/genetics ; Twist-Related Protein 1/genetics
Czasopismo naukowe
Tytuł :
MOF upregulates the estrogen receptor α signaling pathway by its acetylase activity in hepatocellular carcinoma.
Autorzy :
Wei S; Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, China.; Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, China.
Liu W; Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, China.; Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, China.
Sun N; Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, China.; Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, China.
Wu Y; Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, China.; Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, China.; Department of Pathogenic Biology, Shenyang Medical College, Shenyang, China.
Song H; Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, China.; Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, China.
Wang C; Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, China.; Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, China.
Wang S; Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, China.; Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, China.
Zou R; Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, China.; Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, China.
Lin L; Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, China.; Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, China.
Zeng K; Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, China.; Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, China.
Zhou B; Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, China.; Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, China.
Wang M; Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, China.; Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, China.
Luan R; Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, China.; Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, China.
Yang F; Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, China.; Key laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang, China.
Zhao Y; Department of Cell Biology, Key laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, China.; Department of Molecular Oncology, Liao Ning Tumor Hospital, Shenyang, China.
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Źródło :
Cancer science [Cancer Sci] 2021 May; Vol. 112 (5), pp. 1865-1877. Date of Electronic Publication: 2021 Mar 30.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular/*metabolism
Estrogen Receptor alpha/*metabolism
Histone Acetyltransferases/*metabolism
Liver Neoplasms/*metabolism
Acetylation ; Acetylesterase/metabolism ; Animals ; Antibodies/therapeutic use ; Carcinoma, Hepatocellular/enzymology ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/pathology ; Cell Movement ; Cell Proliferation ; Databases, Genetic ; Down-Regulation ; Estrogen Receptor alpha/genetics ; Female ; Heterografts ; Histone Acetyltransferases/deficiency ; Histones/metabolism ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/enzymology ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Lysine/metabolism ; Male ; Mice ; Middle Aged ; Neoplasm Invasiveness ; Signal Transduction ; Transcriptional Activation ; Ubiquitination ; Up-Regulation
Czasopismo naukowe
Tytuł :
Role of estrogen receptor alpha in MEHP-induced proliferation and invasion of SH-SY5Y cells.
Autorzy :
Guo S; Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China. Electronic address: .
Zhang B; Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China; Department of Pediatric Neurology, The First Hospital of Jilin University, Jilin University, Changchun, China. Electronic address: .
Qi W; Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China. Electronic address: .
Cao X; Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China. Electronic address: .
Xu Y; Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China. Electronic address: .
Zhang X; Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China. Electronic address: .
Li X; Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China. Electronic address: .
Zhou L; Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China. Electronic address: .
Ye L; Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, China. Electronic address: .
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Źródło :
Toxicology [Toxicology] 2021 Apr 15; Vol. 453, pp. 152734. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation/*drug effects
Cell Proliferation/*physiology
Diethylhexyl Phthalate/*analogs & derivatives
Estrogen Receptor alpha/*physiology
Cell Line, Tumor ; Cell Movement/drug effects ; Cell Movement/physiology ; Diethylhexyl Phthalate/toxicity ; Dose-Response Relationship, Drug ; Estrogen Receptor alpha/deficiency ; Estrogen Receptor alpha/genetics ; Gene Knockdown Techniques/methods ; Humans ; Neoplasm Invasiveness/pathology
Czasopismo naukowe
Tytuł :
Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening.
Autorzy :
Disch JS; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Duffy JM; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Lee ECY; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Gikunju D; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Chan B; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Levin B; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Monteiro MI; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Talcott SA; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Lau AC; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Zhou F; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Kozhushnyan A; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Westlund NE; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Mullins PB; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Yu Y; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
von Rechenberg M; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Zhang J; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Arnautova YA; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Liu Y; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Zhang Y; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
McRiner AJ; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Keefe AD; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Kohlmann A; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Clark MA; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Cuozzo JW; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Huguet C; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
Arora S; X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 22; Vol. 64 (8), pp. 5049-5066. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
DNA/*chemistry
Estrogen Receptor alpha/*metabolism
Small Molecule Libraries/*chemistry
Animals ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Cell Survival/drug effects ; Click Chemistry ; DNA/metabolism ; Estrogen Antagonists/chemistry ; Estrogen Antagonists/metabolism ; Estrogen Antagonists/pharmacology ; Estrogen Antagonists/therapeutic use ; Estrogen Receptor alpha/chemistry ; Estrogen Receptor alpha/genetics ; Female ; Half-Life ; Humans ; Indoles/chemistry ; Indoles/metabolism ; Kinetics ; Mice ; Small Molecule Libraries/metabolism ; Small Molecule Libraries/pharmacology ; Small Molecule Libraries/therapeutic use ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
A New Anti-Estrogen Discovery Platform Identifies FDA-Approved Imidazole Anti-Fungal Drugs as Bioactive Compounds against ERα Expressing Breast Cancer Cells.
Autorzy :
Cipolletti M; Department of Sciences, University Roma Tre, Viale Guglielmo Marconi, 446, I-00146 Rome, Italy.
Bartoloni S; Department of Sciences, University Roma Tre, Viale Guglielmo Marconi, 446, I-00146 Rome, Italy.
Busonero C; Department of Sciences, University Roma Tre, Viale Guglielmo Marconi, 446, I-00146 Rome, Italy.
Parente M; Department of Sciences, University Roma Tre, Viale Guglielmo Marconi, 446, I-00146 Rome, Italy.
Leone S; Department of Sciences, University Roma Tre, Viale Guglielmo Marconi, 446, I-00146 Rome, Italy.
Acconcia F; Department of Sciences, University Roma Tre, Viale Guglielmo Marconi, 446, I-00146 Rome, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 13; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 13.
Typ publikacji :
Journal Article
MeSH Terms :
Aminopyridines/*pharmacology
Antineoplastic Agents/*pharmacology
Benzimidazoles/*pharmacology
Clotrimazole/*pharmacology
Estrogen Receptor alpha/*antagonists & inhibitors
Imidazoles/*pharmacology
Piperazines/*pharmacology
Pyridines/*pharmacology
Antifungal Agents/pharmacology ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclin-Dependent Kinase 4/antagonists & inhibitors ; Cyclin-Dependent Kinase 4/genetics ; Cyclin-Dependent Kinase 4/metabolism ; Cyclin-Dependent Kinase 6/antagonists & inhibitors ; Cyclin-Dependent Kinase 6/genetics ; Cyclin-Dependent Kinase 6/metabolism ; Drug Approval ; Drug Discovery ; Drug Repositioning ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Drug Synergism ; Estradiol/metabolism ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; MCF-7 Cells ; Proteolysis ; Signal Transduction ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/metabolism ; Spheroids, Cellular/pathology
Czasopismo naukowe
Tytuł :
Nuclear receptor SHP dampens transcription function and abrogates mitotic chromatin association of PXR and ERα via intermolecular interactions.
Autorzy :
Kumar S; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
Vijayan R; School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Dash AK; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
Gourinath S; School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Tyagi RK; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Gene regulatory mechanisms [Biochim Biophys Acta Gene Regul Mech] 2021 Mar; Vol. 1864 (3), pp. 194683. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin*/chemistry
Chromatin*/genetics
Chromatin*/metabolism
Estrogen Receptor alpha*/chemistry
Estrogen Receptor alpha*/genetics
Estrogen Receptor alpha*/metabolism
Mitosis*
Pregnane X Receptor*/chemistry
Pregnane X Receptor*/genetics
Pregnane X Receptor*/metabolism
Promoter Regions, Genetic*
Transcription, Genetic*
Active Transport, Cell Nucleus/genetics ; Animals ; COS Cells ; Chlorocebus aethiops ; HEK293 Cells ; Hep G2 Cells ; Humans ; Receptors, Cytoplasmic and Nuclear/chemistry ; Receptors, Cytoplasmic and Nuclear/genetics ; Receptors, Cytoplasmic and Nuclear/metabolism
Czasopismo naukowe
Tytuł :
Quercetin regulates ERα mediated differentiation of BMSCs through circular RNA.
Autorzy :
Li X; College of Traditional Chinese Medicine, Jinan University, 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, PR China.
Chen R; College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, PR China.
Lei X; College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, PR China.
Wang P; Department of the First Affiliated Hospital, Jinan University, 613 Huangpu Avenue West, Guangzhou, Guangdong 510630, PR China.
Zhu X; College of Traditional Chinese Medicine, Jinan University, 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, PR China; Department of the First Affiliated Hospital, Jinan University, 613 Huangpu Avenue West, Guangzhou, Guangdong 510630, PR China.
Zhang R; College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, PR China. Electronic address: .
Yang L; College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, Guangdong 510632, PR China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Feb 15; Vol. 769, pp. 145172. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :
Journal Article
MeSH Terms :
Estrogen Receptor alpha/*physiology
Mesenchymal Stem Cells/*drug effects
Osteogenesis/*drug effects
Phytoestrogens/*pharmacology
Quercetin/*pharmacology
RNA, Circular/*physiology
Adipogenesis/physiology ; Antioxidants/pharmacology ; Cell Survival ; Cells, Cultured ; Computational Biology ; Estrogen Receptor alpha/genetics ; Gene Expression Regulation ; Humans ; Mesenchymal Stem Cells/physiology ; Osteogenesis/physiology ; Quercetin/physiology ; RNA, Circular/genetics
Czasopismo naukowe
Tytuł :
Novel Biphenyl Amines Inhibit Oestrogen Receptor (ER)-α in ER-Positive Mammary Carcinoma Cells.
Autorzy :
Basappa B; Laboratory of Chemical Biology, Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India.; Department of Chemistry, Bangalore University, Bangalore 560001, India.
Chumadathil Pookunoth B; Department of Chemistry, Bangalore University, Bangalore 560001, India.
Shinduvalli Kempasiddegowda M; Tsinghua Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Beijing 518055, China.
Knchugarakoppal Subbegowda R; Institution of Excellence, University of Mysore, Manasagangotri, Mysore 570006, India.
Lobie PE; Tsinghua Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Beijing 518055, China.; Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Beijing 518055, China.; Shenzhen Bay Laboratory, Shenzhen 518055, China.
Pandey V; Tsinghua Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Beijing 518055, China.; Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Beijing 518055, China.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 03; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*/drug therapy
Breast Neoplasms*/metabolism
Breast Neoplasms*/pathology
Estrogen Receptor alpha*/antagonists & inhibitors
Estrogen Receptor alpha*/metabolism
Neoplasm Proteins*/antagonists & inhibitors
Neoplasm Proteins*/metabolism
Antineoplastic Agents/*pharmacology
Biphenyl Compounds/*pharmacology
Animals ; Female ; Humans ; MCF-7 Cells
Czasopismo naukowe
Tytuł :
R-sulforaphane modulates the expression profile of AhR, ERα, Nrf2, NQO1, and GSTP in human breast cell lines.
Autorzy :
Licznerska B; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Poznań, Poland. .
Szaefer H; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Poznań, Poland.
Krajka-Kuźniak V; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Poznań, Poland.
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Feb; Vol. 476 (2), pp. 525-533. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Journal Article
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*biosynthesis
Breast Neoplasms/*drug therapy
Estrogen Receptor alpha/*biosynthesis
Glutathione S-Transferase pi/*biosynthesis
Isothiocyanates/*pharmacology
NAD(P)H Dehydrogenase (Quinone)/*biosynthesis
NF-E2-Related Factor 2/*biosynthesis
Receptors, Aryl Hydrocarbon/*biosynthesis
Sulfoxides/*pharmacology
Anticarcinogenic Agents/pharmacology ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Female ; Glutathione S-Transferase pi/genetics ; Glutathione S-Transferase pi/metabolism ; Humans ; NAD(P)H Dehydrogenase (Quinone)/genetics ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism ; Transcriptome
Czasopismo naukowe

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