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Tytuł:
Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment in male mice.
Autorzy:
Horkeby K; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Klinfarmlab, Vita Stråket 11, 413 45, Göteborg, Sweden. .
Farman HH; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Klinfarmlab, Vita Stråket 11, 413 45, Göteborg, Sweden.
Movérare-Skrtic S; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Klinfarmlab, Vita Stråket 11, 413 45, Göteborg, Sweden.
Lionikaite V; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Klinfarmlab, Vita Stråket 11, 413 45, Göteborg, Sweden.
Wu J; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Klinfarmlab, Vita Stråket 11, 413 45, Göteborg, Sweden.
Henning P; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Klinfarmlab, Vita Stråket 11, 413 45, Göteborg, Sweden.
Windahl S; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Klinfarmlab, Vita Stråket 11, 413 45, Göteborg, Sweden.; Division of Pathology, Department of Laboratory Medicine, Karolinska Institute, Huddinge, Sweden.
Sjögren K; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Klinfarmlab, Vita Stråket 11, 413 45, Göteborg, Sweden.
Ohlsson C; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Klinfarmlab, Vita Stråket 11, 413 45, Göteborg, Sweden.; Department of Drug Treatment, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden.
Lagerquist MK; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Klinfarmlab, Vita Stråket 11, 413 45, Göteborg, Sweden.
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Źródło:
Scientific reports [Sci Rep] 2022 Dec 27; Vol. 12 (1), pp. 22449. Date of Electronic Publication: 2022 Dec 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Estrogen Receptor alpha*/genetics
Estrogen Receptor alpha*/metabolism
Estrogens*/pharmacology
Humans ; Mice ; Male ; Animals ; Child ; Infant ; Phosphorylation ; Bone and Bones/diagnostic imaging ; Bone and Bones/metabolism ; Estradiol ; Body Weight
Czasopismo naukowe
Tytuł:
Methylpiperidinopyrazole Attenuates Estrogen-Induced Mitochondrial Energy Production and Subsequent Osteoblast Maturation via an Estrogen Receptor Alpha-Dependent Mechanism.
Autorzy:
Yeh PS; Department of Neurology, Chi Mei Medical Center, Tainan 710, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Chen JT; Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Department of Anesthesiology, Shuang Ho Hospital, New Taipei City 235, Taiwan.
Cherng YG; Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Department of Anesthesiology, Shuang Ho Hospital, New Taipei City 235, Taiwan.
Yang ST; Department of Neurosurgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Tai YT; Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Cell Physiology and Molecular Image Research Center; Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.
Chen RM; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Cell Physiology and Molecular Image Research Center; Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 110, Taiwan.; Anesthesiology and Health Policy Research Center, Taipei Medical University, Taipei 110, Taiwan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2020 Jun 22; Vol. 25 (12). Date of Electronic Publication: 2020 Jun 22.
Typ publikacji:
Journal Article
MeSH Terms:
Estrogen Receptor alpha/*genetics
Estrogens/*genetics
Osteoporosis/*drug therapy
Pyrazoles/*pharmacology
Animals ; Bone Morphogenetic Protein 6/genetics ; Cell Differentiation/drug effects ; Electron Transport Complex IV/genetics ; Estrogen Receptor alpha/antagonists & inhibitors ; Estrogen Receptor beta/antagonists & inhibitors ; Estrogen Receptor beta/genetics ; Estrogens/metabolism ; Female ; Gene Expression Regulation/drug effects ; Mitochondria/genetics ; Mitochondria/metabolism ; Osteoblasts/drug effects ; Osteocalcin/genetics ; Osteogenesis/drug effects ; Osteoporosis/metabolism ; Osteoporosis/pathology ; Pyrazoles/chemical synthesis ; Pyrazoles/chemistry ; Rats ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł:
Elucidating Binding Sites and Affinities of ERα Agonists and Antagonists to Human Alpha-Fetoprotein by In Silico Modeling and Point Mutagenesis.
Autorzy:
Moldogazieva NT; Laboratory of Bioinformatics, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Ostroverkhova DS; Laboratory of Bioinformatics, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.; Department of Bioengineering, M.V. Lomonosov Moscow State University, 119991 Moscow, Russia.
Kuzmich NN; Laboratory of Bioinformatics, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.; Department of Drug Safety, I.M. Smorodintsev Research Institute of Influenza, WHO National Influenza Centre of Russia, 197376 Saint Petersburg, Russia.
Kadochnikov VV; Department of Food Biotechnology and Engineering, Saint Petersburg National Research University of Information Technologies, Mechanics and Optics, 197101 Saint-Petersburg, Russia.
Terentiev AA; Deparment of Biochemistry and Molecular Biology, N.I. Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Porozov YB; Laboratory of Bioinformatics, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.; Department of Food Biotechnology and Engineering, Saint Petersburg National Research University of Information Technologies, Mechanics and Optics, 197101 Saint-Petersburg, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 30; Vol. 21 (3). Date of Electronic Publication: 2020 Jan 30.
Typ publikacji:
Journal Article
MeSH Terms:
Estradiol/*metabolism
Estrogen Receptor Modulators/*metabolism
Estrogen Receptor alpha/*metabolism
Estrogens/*metabolism
alpha-Fetoproteins/*metabolism
Amino Acid Sequence ; Amino Acid Substitution ; Binding Sites ; Estrogen Receptor alpha/agonists ; Estrogen Receptor alpha/antagonists & inhibitors ; Female ; Humans ; Ligands ; Models, Molecular ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Mutagenesis ; Sequence Alignment
Czasopismo naukowe
Tytuł:
Estrogen modulates epithelial progenitor cells in rat vagina.
Autorzy:
Chung HS; Department of Urology, Chonnam National University Medical School, Gwangju, Korea.
Lee HS; Department of Urology, Chonnam National University Medical School, Gwangju, Korea.
Park K; Department of Urology, Chonnam National University Medical School, Gwangju, Korea. .
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Źródło:
Investigative and clinical urology [Investig Clin Urol] 2021 May; Vol. 62 (3), pp. 349-353. Date of Electronic Publication: 2021 Apr 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial Cells/*drug effects
Estradiol/*pharmacology
Estrogens/*pharmacology
Stem Cells/*drug effects
Vagina/*drug effects
Vagina/*pathology
Animals ; Epithelial Cells/metabolism ; Estrogen Receptor alpha/metabolism ; Female ; Hyaluronan Receptors/metabolism ; Models, Animal ; Mucous Membrane/drug effects ; Mucous Membrane/metabolism ; Mucous Membrane/pathology ; Ovariectomy ; Rats ; Rats, Sprague-Dawley ; Receptors, Progesterone/metabolism ; Stem Cells/metabolism ; Vagina/metabolism
Czasopismo naukowe
Tytuł:
CHRNA5 belongs to the secondary estrogen signaling network exhibiting prognostic significance in breast cancer.
Autorzy:
Shehwana H; Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey.; Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, 46000, Pakistan.; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Keskus AG; Interdisciplinary Program in Neuroscience, Bilkent University, 06800, Ankara, Turkey.
Ozdemir SE; Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey.
Acikgöz AA; Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey.
Biyik-Sit R; Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey.
Cagnan I; Department of Biological Sciences, Faculty of Arts and Sciences, Eastern Mediterranean University, Famagusta, North Cyprus, Turkey.; Department of Stem Cell Sciences, Graduate School of Health Sciences, Center for Stem Cell Research and Development, Hacettepe University, 06100, Ankara, Turkey.
Gunes D; Interdisciplinary Program in Neuroscience, Bilkent University, 06800, Ankara, Turkey.
Jahja E; Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey.
Cingir-Koker S; Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey.
Olmezer G; Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey.
Sucularli C; Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey.; Department of Bioinformatics, Institute of Health Sciences, Hacettepe University, 06100, Ankara, Turkey.
Konu O; Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey. .; Interdisciplinary Program in Neuroscience, Bilkent University, 06800, Ankara, Turkey. .; UNAM-Institute of Materials Science and Nanotechnology, Bilkent University, 06800, Ankara, Turkey. .
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Źródło:
Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2021 Apr; Vol. 44 (2), pp. 453-472. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Signal Transduction*/drug effects
Breast Neoplasms/*metabolism
Estrogens/*metabolism
Nerve Tissue Proteins/*metabolism
Receptors, Nicotinic/*metabolism
Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Estrogen Receptor alpha/metabolism ; Estrogens/pharmacology ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Regulatory Networks ; Humans ; Nerve Tissue Proteins/genetics ; Prognosis ; RNA, Small Interfering/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Nicotinic/genetics ; Transcription Factors/metabolism ; Up-Regulation/drug effects ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł:
Binding of Androgen- and Estrogen-Like Flavonoids to Their Cognate (Non)Nuclear Receptors: A Comparison by Computational Prediction.
Autorzy:
D'Arrigo G; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Turin, Italy.
Gianquinto E; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Turin, Italy.
Rossetti G; Institute for Neuroscience and Medicine (INM-9) and Institute for Advanced Simulations (IAS-5) 'Computational Biomedicine', Forschungszentrum Jülich, 52425 Jülich, Germany.; Jülich Supercomputing Center (JSC), Forschungszentrum Jülich, 52425 Jülich, Germany.; Department of Neurology, RWTH, Aachen University, 52074 Aachen, Germany.
Cruciani G; Department of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia, Italy.
Lorenzetti S; Istituto Superiore di Sanità (ISS), Department of Food Safety, Nutrition and Veterinary Public Health, Viale Regina Elena 299, 00161 Rome, Italy.
Spyrakis F; Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Turin, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Mar 14; Vol. 26 (6). Date of Electronic Publication: 2021 Mar 14.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Androgens/*metabolism
Cell Nucleus/*metabolism
Estrogens/*metabolism
Flavonoids/*metabolism
Protein Binding/*physiology
Receptors, Cell Surface/*metabolism
Estradiol/metabolism ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/metabolism ; Humans ; Molecular Docking Simulation ; Receptors, Estrogen ; Testosterone/metabolism
Czasopismo naukowe
Tytuł:
The Cell-Free Expression of MiR200 Family Members Correlates with Estrogen Sensitivity in Human Epithelial Ovarian Cells.
Autorzy:
Márton É; Department of Human Genetics, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Varga A; Department of Human Genetics, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Széles L; Department of Human Genetics, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Göczi L; Department of Human Genetics, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Penyige A; Department of Human Genetics, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.; Faculty of Pharmacology, University of Debrecen, H-4032 Debrecen, Hungary.
Nagy B; Department of Human Genetics, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
Szilágyi M; Department of Human Genetics, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 20; Vol. 21 (24). Date of Electronic Publication: 2020 Dec 20.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Ovarian Epithelial/*genetics
Estrogen Receptor alpha/*genetics
Estrogens/*genetics
MicroRNAs/*genetics
Biomarkers, Tumor/genetics ; Cadherins/genetics ; Carcinoma, Ovarian Epithelial/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Endodeoxyribonucleases/genetics ; Epithelial-Mesenchymal Transition/genetics ; Estradiol/metabolism ; Estrogens/metabolism ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Neoplasm Proteins/genetics ; RNA, Messenger/genetics ; Zinc Finger E-box-Binding Homeobox 1/genetics
Czasopismo naukowe
Tytuł:
Silver nanoparticles compromise the development of mouse pubertal mammary glands through disrupting internal estrogen signaling.
Autorzy:
Wang Z; School of Public Health, Xinxiang Medical University, Xinxiang, PR China.
Li Q; School of Public Health, Xinxiang Medical University, Xinxiang, PR China.
Xu L; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, PR China.; School of Environmental Sciences, University of Chinese Academy of Sciences, Beijing, PR China.
Ma J; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, PR China.; School of Environmental Sciences, University of Chinese Academy of Sciences, Beijing, PR China.
Wei B; School of Public Health, Xinxiang Medical University, Xinxiang, PR China.
An Z; School of Public Health, Xinxiang Medical University, Xinxiang, PR China.
Wu W; School of Public Health, Xinxiang Medical University, Xinxiang, PR China.
Liu S; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, PR China.; School of Environmental Sciences, University of Chinese Academy of Sciences, Beijing, PR China.
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Źródło:
Nanotoxicology [Nanotoxicology] 2020 Aug; Vol. 14 (6), pp. 740-756. Date of Electronic Publication: 2020 May 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endocrine Disruptors/*toxicity
Estrogens/*metabolism
Mammary Glands, Animal/*drug effects
Metal Nanoparticles/*toxicity
Silver/*toxicity
Animals ; Dose-Response Relationship, Drug ; Endocrine Disruptors/pharmacokinetics ; Epithelium/drug effects ; Epithelium/growth & development ; Epithelium/metabolism ; Estrogen Receptor alpha/metabolism ; Estrogens/pharmacology ; Female ; Mammary Glands, Animal/growth & development ; Mammary Glands, Animal/metabolism ; Mice ; Mice, Inbred BALB C ; Particle Size ; Signal Transduction ; Silver/pharmacokinetics ; Surface Properties ; Tissue Distribution
Czasopismo naukowe
Tytuł:
Estrogen-ERα signaling and DNA hypomethylation co-regulate expression of stem cell protein PIWIL1 in ERα-positive endometrial cancer cells.
Autorzy:
Chen Z; Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No.910, Hengshan Road, Shanghai, 200030, China.; Shanghai Municipal Key Clinical Specialty, Shanghai, China.; Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China.
Yang HJ; Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No.910, Hengshan Road, Shanghai, 200030, China.; Shanghai Municipal Key Clinical Specialty, Shanghai, China.; Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China.
Lin Q; Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No.910, Hengshan Road, Shanghai, 200030, China.; Shanghai Municipal Key Clinical Specialty, Shanghai, China.; Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China.
Zhu MJ; Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No.910, Hengshan Road, Shanghai, 200030, China.; Shanghai Municipal Key Clinical Specialty, Shanghai, China.; Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China.
Yu YY; Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No.910, Hengshan Road, Shanghai, 200030, China.; Shanghai Municipal Key Clinical Specialty, Shanghai, China.; Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China.
He XY; Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No.910, Hengshan Road, Shanghai, 200030, China. .; Shanghai Municipal Key Clinical Specialty, Shanghai, China. .; Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. .
Wan XP; Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, Tong Ji University School of Medicine, No. 536, Changle Road, Shanghai, 200080, China. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2020 Jun 05; Vol. 18 (1), pp. 84. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms:
Argonaute Proteins/*metabolism
Carcinogenesis/*metabolism
Endometrial Neoplasms/*metabolism
Estrogen Receptor alpha/*metabolism
Estrogens/*metabolism
Cell Line, Tumor ; Cell Proliferation ; DNA Methylation ; Female ; Gene Expression Regulation, Neoplastic ; Humans
Czasopismo naukowe
Tytuł:
GRP78 positively regulates estrogen‑stimulated cell growth mediated by ER‑α36 in gastric cancer cells.
Autorzy:
Fu Z; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Wang X; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Zhou H; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Li Y; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Chen Y; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
Wang Z; Shenogen Pharma Group, Beijing 102206, P.R. China.
Liu L; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2017 Dec; Vol. 16 (6), pp. 8329-8334. Date of Electronic Publication: 2017 Sep 26.
Typ publikacji:
Journal Article
MeSH Terms:
Estrogen Receptor alpha/*metabolism
Estrogens/*metabolism
Heat-Shock Proteins/*metabolism
Stomach Neoplasms/*metabolism
Adult ; Aged ; Aged, 80 and over ; Cell Line, Tumor ; Cell Proliferation ; Cyclin D1/metabolism ; Endoplasmic Reticulum Chaperone BiP ; Estrogen Receptor alpha/genetics ; Estrogens/pharmacology ; Female ; Gene Expression ; Heat-Shock Proteins/genetics ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Stomach Neoplasms/pathology ; Tissue Array Analysis
Czasopismo naukowe
Tytuł:
Divergent Regulation of Myotube Formation and Gene Expression by E2 and EPA during In-Vitro Differentiation of C2C12 Myoblasts.
Autorzy:
Lacham-Kaplan O; Exercise and Nutrition Research Program, Mary Mackillop Institute for Health Research, Australian Catholic University, Melbourne 3000, Australia.
Camera DM; Department of Health and Medical Sciences, Swinburne University of Technology, Melbourne 3122, Australia.
Hawley JA; Exercise and Nutrition Research Program, Mary Mackillop Institute for Health Research, Australian Catholic University, Melbourne 3000, Australia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 23; Vol. 21 (3). Date of Electronic Publication: 2020 Jan 23.
Typ publikacji:
Journal Article
MeSH Terms:
Eicosapentaenoic Acid/*pharmacology
Estrogens/*pharmacology
Muscle Development/*drug effects
Muscle Fibers, Skeletal/*drug effects
Myoblasts/*drug effects
Myoblasts/*metabolism
Animals ; Cell Line ; DNA Glycosylases/metabolism ; Drug Synergism ; Estrogen Receptor alpha/metabolism ; Fatty Acids, Unsaturated/pharmacology ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/genetics ; Gene Ontology ; High-Throughput Nucleotide Sequencing ; Membrane Proteins/metabolism ; Mice ; Mitogen-Activated Protein Kinase 11/metabolism ; Muscle Development/genetics ; Muscle Fibers, Skeletal/metabolism ; Muscle Proteins/metabolism ; MyoD Protein/metabolism ; Myoblasts/cytology ; Myogenin/metabolism ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Transcriptome/drug effects ; Transcriptome/genetics
Czasopismo naukowe
Tytuł:
Estrogen modulation of pain perception with a novel 17β-estradiol pretreatment regime in ovariectomized rats.
Autorzy:
Zhang W; Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Xueshi Road 1, Hangzhou, 310006, China.
Wu H; Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Xueshi Road 1, Hangzhou, 310006, China.
Xu Q; Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Xueshi Road 1, Hangzhou, 310006, China.
Chen S; Zhejiang University School of Medicine, 866th Yuhangtang Road, Hangzhou, 310058, China.
Sun L; Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Xueshi Road 1, Hangzhou, 310006, China.
Jiao C; Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Xueshi Road 1, Hangzhou, 310006, China.
Wang L; Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Xueshi Road 1, Hangzhou, 310006, China.
Fu F; Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Xueshi Road 1, Hangzhou, 310006, China.
Feng Y; Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Xueshi Road 1, Hangzhou, 310006, China.
Qian X; Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Xueshi Road 1, Hangzhou, 310006, China.
Chen X; Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Xueshi Road 1, Hangzhou, 310006, China. .
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Źródło:
Biology of sex differences [Biol Sex Differ] 2020 Jan 09; Vol. 11 (1), pp. 2. Date of Electronic Publication: 2020 Jan 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Estradiol/*administration & dosage
Estrogens/*physiology
Hyperalgesia/*physiopathology
Nociception/*physiology
Pain Perception/*physiology
Animals ; Estrogen Receptor alpha/physiology ; Estrogen Receptor beta/physiology ; Estrogens/blood ; Female ; Neurons/drug effects ; Neurons/physiology ; Nociception/drug effects ; Ovariectomy ; Pain Perception/drug effects ; Rats, Sprague-Dawley ; Spinal Cord/drug effects ; Spinal Cord/physiopathology
Czasopismo naukowe
Tytuł:
Differential effects of genistein and 8-prenylgenistein on reproductive tissues in immature female mice.
Autorzy:
Li XL; a School of Medical Instrument and Food Engineering , University of Shanghai for Science and Technology , Shanghai , P. R. China.
Sui L; a School of Medical Instrument and Food Engineering , University of Shanghai for Science and Technology , Shanghai , P. R. China.
Lin FH; b Department of Orthopaedic , Shenzhen Pingle Orthopaedic Hospital , Shenzhen , P. R. China.
Lian Y; b Department of Orthopaedic , Shenzhen Pingle Orthopaedic Hospital , Shenzhen , P. R. China.
Ai LZ; a School of Medical Instrument and Food Engineering , University of Shanghai for Science and Technology , Shanghai , P. R. China.
Zhang Y; c Spine Disease Research Institute , Longhua Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine , Shanghai , P. R. China.; d Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education , Shanghai , P. R. China.
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Źródło:
Pharmaceutical biology [Pharm Biol] 2019 Dec; Vol. 57 (1), pp. 226-230.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Estrogens/*pharmacology
Genistein/*analogs & derivatives
Genistein/*pharmacokinetics
Uterus/*drug effects
Vagina/*drug effects
Administration, Oral ; Animals ; Dose-Response Relationship, Drug ; Estrogen Receptor alpha/metabolism ; Estrogens/administration & dosage ; Estrogens/toxicity ; Female ; Gene Expression Regulation/drug effects ; Genistein/administration & dosage ; Genistein/pharmacology ; Genistein/toxicity ; Mice ; Up-Regulation/drug effects ; Uterus/metabolism ; Vagina/metabolism
Czasopismo naukowe
Tytuł:
Late Onset of Estrogen Therapy Impairs Carotid Function of Senescent Females in Association with Altered Prostanoid Balance and Upregulation of the Variant ERα36.
Autorzy:
Costa TJ; Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-900, Brazil.; Facultat de Medicina, Departament de Farmacologia, Terapèutica i Toxicologia, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.; Group of Atherosclerosis and Coronary Disease, Institut Clinic del Torax, Institut d'Investigaciones Biomédiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Pharmacology Department, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo 14049-900, Brazil.
Jiménez-Altayó F; Facultat de Medicina, Departament de Farmacologia, Terapèutica i Toxicologia, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Echem C; Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-900, Brazil.
Akamine EH; Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-900, Brazil.
Tostes R; Pharmacology Department, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo 14049-900, Brazil.
Vila E; Facultat de Medicina, Departament de Farmacologia, Terapèutica i Toxicologia, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Dantas AP; Group of Atherosclerosis and Coronary Disease, Institut Clinic del Torax, Institut d'Investigaciones Biomédiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain. .
Carvalho MHC; Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-900, Brazil.
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Źródło:
Cells [Cells] 2019 Oct 08; Vol. 8 (10). Date of Electronic Publication: 2019 Oct 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aging*
Vasoconstriction*
Carotid Arteries/*physiopathology
Estrogen Receptor alpha/*genetics
Estrogens/*adverse effects
Prostaglandins/*metabolism
Animals ; Carotid Arteries/metabolism ; Estrogens/therapeutic use ; Female ; Gene Expression Regulation ; Mice
Czasopismo naukowe
Tytuł:
Oestrogen Non-Genomic Signalling is Activated in Tamoxifen-Resistant Breast Cancer.
Autorzy:
Poulard C; Université de Lyon, F-69000 Lyon, France. .; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. .; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. .
Jacquemetton J; Université de Lyon, F-69000 Lyon, France. .; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. .; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. .
Trédan O; Université de Lyon, F-69000 Lyon, France. .; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. .; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. .; Centre Léon Bérard, Medical Oncology Department, F-69000 Lyon, France. .
Cohen PA; Université de Lyon, F-69000 Lyon, France. .; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. .; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. .
Vendrell J; Université de Lyon, F-69000 Lyon, France. .; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. .; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. .; Solid Tumor Laboratory, Department of Pathology and Oncobiology, CHU Montpellier, 34000 Montpellier, France. .
Ghayad SE; Université de Lyon, F-69000 Lyon, France. .; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. .; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. .; Department of Biology, Faculty of Science II, EDST, Lebanese University, Fanar 90656, Lebanon. .
Treilleux I; Université de Lyon, F-69000 Lyon, France. .; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. .; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. .; Centre Léon Bérard, Pathology Department, F-69000 Lyon, France. .
Marangoni E; Translational Research Department, Institut Curie, 75005 Paris, France. .
Le Romancer M; Université de Lyon, F-69000 Lyon, France. .; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. .; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, F-69000 Lyon, France. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Jun 05; Vol. 20 (11). Date of Electronic Publication: 2019 Jun 05.
Typ publikacji:
Journal Article
MeSH Terms:
Signal Transduction*
Breast Neoplasms/*genetics
Breast Neoplasms/*pathology
Drug Resistance, Neoplasm/*drug effects
Estrogens/*pharmacology
Tamoxifen/*pharmacology
Animals ; Estrogen Receptor alpha/metabolism ; Female ; Humans ; MCF-7 Cells ; Mice, Nude ; Phosphatidylinositol 3-Kinases/metabolism ; src-Family Kinases/metabolism
Czasopismo naukowe
Tytuł:
Estrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ERα in Breast Cancer Cells.
Autorzy:
González-Bengtsson A; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Asadi A; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Gao H; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Dahlman-Wright K; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Jacobsson A; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
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Źródło:
PloS one [PLoS One] 2016 Oct 27; Vol. 11 (10), pp. e0164241. Date of Electronic Publication: 2016 Oct 27 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Acetyltransferases/*genetics
Acetyltransferases/*metabolism
Estrogen Receptor alpha/*metabolism
Estrogens/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
Estrogen Receptor alpha/deficiency ; Estrogen Receptor alpha/genetics ; Fatty Acid Elongases ; Fatty Acids, Unsaturated/biosynthesis ; Gene Knockdown Techniques ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Promoter Regions, Genetic/drug effects ; Promoter Regions, Genetic/genetics ; Response Elements/drug effects ; Response Elements/genetics ; Tamoxifen/pharmacology
Czasopismo naukowe
Tytuł:
Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen.
Autorzy:
Owens GL; Division of Molecular & Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine & Health, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M20 4QL, United Kingdom.
Lawrence KM; Division of Molecular & Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine & Health, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M20 4QL, United Kingdom.
Jackson TR; Division of Molecular & Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine & Health, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M20 4QL, United Kingdom.
Crosbie EJ; Division of Molecular & Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine & Health, St Mary's Hospital, University of Manchester, Oxford Road, Manchester, M13 9WL, United Kingdom.
Sayan BS; Division of Molecular & Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine & Health, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M20 4QL, United Kingdom.
Kitchener HC; Division of Molecular & Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine & Health, St Mary's Hospital, University of Manchester, Oxford Road, Manchester, M13 9WL, United Kingdom.
Townsend PA; Division of Molecular & Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine & Health, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M20 4QL, United Kingdom.
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Źródło:
Cancer medicine [Cancer Med] 2017 Feb; Vol. 6 (2), pp. 408-415. Date of Electronic Publication: 2017 Jan 21.
Typ publikacji:
Journal Article
MeSH Terms:
Endometrial Neoplasms/*metabolism
Estrogen Receptor alpha/*genetics
Estrogen Receptor beta/*genetics
Estrogens/*pharmacology
Receptors, Corticotropin-Releasing Hormone/*metabolism
Urocortins/*metabolism
Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Endometrial Neoplasms/genetics ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/metabolism ; Female ; Humans ; Neoplasm Invasiveness ; Receptors, Corticotropin-Releasing Hormone/genetics ; Urocortins/genetics
Czasopismo naukowe
Tytuł:
Estrogen receptor alpha activation enhances mitochondrial function and systemic metabolism in high-fat-fed ovariectomized mice.
Autorzy:
Hamilton DJ; Center for Metabolic and Bioenergetics Research, Houston Methodist Research Institute and Weill Cornell Medical College, Houston, Texas Houston Methodist Research Institute, Houston, Texas Houston Methodist Department of Medicine, Houston, Texas.
Minze LJ; Houston Methodist Research Institute, Houston, Texas.
Kumar T; Houston Methodist Research Institute, Houston, Texas.
Cao TN; Houston Methodist Research Institute, Houston, Texas.
Lyon CJ; Houston Methodist Research Institute, Houston, Texas.
Geiger PC; University of Kansas Medical Center, Kansas City, Kansas.
Hsueh WA; Ohio State University, Columbus, Ohio.
Gupte AA; Center for Metabolic and Bioenergetics Research, Houston Methodist Research Institute and Weill Cornell Medical College, Houston, Texas Houston Methodist Research Institute, Houston, Texas .
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Źródło:
Physiological reports [Physiol Rep] 2016 Sep; Vol. 4 (17).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Diet, High-Fat/*methods
Energy Metabolism/*drug effects
Estrogen Receptor alpha/*agonists
Estrogen Replacement Therapy/*adverse effects
Estrogens/*pharmacology
Mitochondria/*drug effects
Ovariectomy/*methods
Adipose Tissue/metabolism ; Animals ; Diet, High-Fat/adverse effects ; Energy Metabolism/physiology ; Estrogen Receptor alpha/metabolism ; Female ; Glucose/metabolism ; Insulin Resistance/physiology ; Liver/metabolism ; Mice ; Mitochondria/metabolism ; Models, Animal ; Muscle, Skeletal/metabolism ; Ovariectomy/veterinary ; Weight Gain
Czasopismo naukowe
Tytuł:
Estrogen rescues heart failure through estrogen receptor Beta activation.
Autorzy:
Iorga A; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.; Present address: Department of Medicine, Division of Gastroenterology/Liver, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Umar S; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.
Ruffenach G; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.
Aryan L; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.
Li J; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.
Sharma S; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.
Motayagheni N; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.; Present Address: Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston-Salem, NC 27109, USA.
Nadadur RD; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.
Bopassa JC; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.; Present address: Department of Physiology, University of Texas Health Science Center, San Antonio, TX, 78229, USA.
Eghbali M; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA. .
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Źródło:
Biology of sex differences [Biol Sex Differ] 2018 Oct 30; Vol. 9 (1), pp. 48. Date of Electronic Publication: 2018 Oct 30.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Estradiol/*therapeutic use
Estrogen Receptor beta/*physiology
Estrogens/*therapeutic use
Heart Failure/*drug therapy
Animals ; Cells, Cultured ; Coculture Techniques ; Estradiol/pharmacology ; Estrogen Receptor alpha/agonists ; Estrogen Receptor alpha/physiology ; Estrogen Receptor beta/agonists ; Estrogen Receptor beta/antagonists & inhibitors ; Estrogens/pharmacology ; Heart/drug effects ; Heart/physiology ; Heart Failure/physiopathology ; Male ; Mice ; Rats
Czasopismo naukowe
Tytuł:
Comparison the Effect of Ferutinin and 17β-Estradiol on Bone Mineralization of Developing Zebrafish ( Danio rerio ) Larvae.
Autorzy:
Zare Mirakabad H; Department of Biotechnology and Plant Breeding, Ferdowsi University of Mashhad, Mashhad 91775-1163, Iran. ho_.
Farsi M; Department of Biotechnology and Plant Breeding, Ferdowsi University of Mashhad, Mashhad 91775-1163, Iran. .
Malekzadeh Shafaroudi S; Department of Biotechnology and Plant Breeding, Ferdowsi University of Mashhad, Mashhad 91775-1163, Iran. .
Bagheri A; Department of Biotechnology and Plant Breeding, Ferdowsi University of Mashhad, Mashhad 91775-1163, Iran. .
Iranshahi M; Department of Pharmacognosy; Mashhad University of Medical Sciences, Mashhad 91886-17871, Iran. .
Moshtaghi N; Department of Biotechnology and Plant Breeding, Ferdowsi University of Mashhad, Mashhad 91775-1163, Iran. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Mar 26; Vol. 20 (6). Date of Electronic Publication: 2019 Mar 26.
Typ publikacji:
Journal Article
MeSH Terms:
Benzoates/*pharmacology
Calcification, Physiologic/*drug effects
Cycloheptanes/*pharmacology
Estradiol/*pharmacology
Estrogens/*pharmacology
Sesquiterpenes/*pharmacology
Animals ; Bone Morphogenetic Protein 2/genetics ; Bone Morphogenetic Protein 2/metabolism ; Bridged Bicyclo Compounds/pharmacology ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Larva/drug effects ; Larva/metabolism ; Zebrafish ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
Czasopismo naukowe

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