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Tytuł :
DNA and RNA editing without sequence limitation using the flap endonuclease 1 guided by hairpin DNA probes.
Autorzy :
Tian K; School of Basic Medical Science and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210000, China.
Guo Y; Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA.
Zou B; Department of Pharmacology, Jinling Hospital, Medical School, Nanjing University, Nanjing 210000, China.
Wang L; School of Basic Medical Science and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210000, China.
Zhang Y; School of Basic Medical Science and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210000, China.
Qi Z; School of Basic Medical Science and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210000, China.
Zhou J; Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA.
Wang X; Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA.
Zhou G; Department of Pharmacology, Jinling Hospital, Medical School, Nanjing University, Nanjing 210000, China.
Wei L; School of Basic Medical Science and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210000, China.
Xu S; School of Basic Medical Science and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210000, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Nov 18; Vol. 48 (20), pp. e117.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inverted Repeat Sequences*
RNA Editing*
Archaeoglobus fulgidus/*enzymology
Flap Endonucleases/*metabolism
Gene Editing/*methods
Archaeoglobus fulgidus/genetics ; Base Pair Mismatch ; DNA/chemistry ; DNA Probes/chemistry ; DNA Probes/genetics ; DNA, Single-Stranded ; Escherichia coli/genetics ; Flap Endonucleases/chemistry ; Flap Endonucleases/genetics ; Flap Endonucleases/isolation & purification ; HEK293 Cells ; Humans ; In Vitro Techniques ; Nucleic Acid Conformation ; RNA/chemistry ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Editing through infection.
Autorzy :
Dinesh-Kumar SP; Department of Plant Biology, University of California, Davis, Davis, CA, USA.; The Genome Center, University of California, Davis, Davis, CA, USA.
Voytas DF; Department of Genetics, Cell Biology and Development, University of Minnesota, St. Paul, MN, USA. .; Center for Precision Plant Genomics, University of Minnesota, St. Paul, MN, USA. .; Center for Genome Engineering, University of Minnesota, St. Paul, MN, USA. .
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Źródło :
Nature plants [Nat Plants] 2020 Jul; Vol. 6 (7), pp. 738-739.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Gene Editing*
Infections*
CRISPR-Cas Systems ; Clustered Regularly Interspaced Short Palindromic Repeats ; Humans ; RNA Editing
Czasopismo naukowe
Tytuł :
Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing.
Autorzy :
Nguyen Tran MT; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Tasmania, Australia. .
Mohd Khalid MKN; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Tasmania, Australia.
Wang Q; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Tasmania, Australia.
Walker JKR; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Tasmania, Australia.
Lidgerwood GE; Department of Surgery, The University of Melbourne, Victoria, Australia.; Department of Anatomy and Neuroscience, The University of Melbourne, Victoria, Australia.
Dilworth KL; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia.
Lisowski L; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia.; Military Institute of Hygiene and Epidemiology, The Biological Threats Identification and Countermeasure Centre, Puławy, Poland.
Pébay A; Department of Surgery, The University of Melbourne, Victoria, Australia.; Department of Anatomy and Neuroscience, The University of Melbourne, Victoria, Australia.
Hewitt AW; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Tasmania, Australia.; Centre for Eye Research Australia, The University of Melbourne, Victoria, Australia.
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Źródło :
Nature communications [Nat Commun] 2020 Sep 25; Vol. 11 (1), pp. 4871. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems*
Adenine/*chemistry
Gene Editing/*methods
Genetic Engineering/*methods
RNA/*metabolism
CRISPR-Associated Protein 9 ; Cytosine ; DNA ; Exome ; Genome ; HEK293 Cells ; Humans ; RNA Editing
Czasopismo naukowe
Tytuł :
CRISPR-Cas13 Inhibitors Block RNA Editing in Bacteria and Mammalian Cells.
Autorzy :
Lin P; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA; Wound Trauma Medical Center, State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China.
Qin S; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Pu Q; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Wang Z; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA; West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China.
Wu Q; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA; Department of Pediatrics, Ruijin Hospital affiliated to Shanghai Jiao Tong University of Medicine, Shanghai 200025, China.
Gao P; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Schettler J; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA.
Guo K; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA.
Li R; Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China.
Li G; Inflammations & Allergic Diseases Research Laboratory, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646004, China.
Huang C; West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China.
Wei Y; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Gao GF; Chinese Academy of Sciences (CAS) Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 101408, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Research Network of Immunity and Health, Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China.
Jiang J; Wound Trauma Medical Center, State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China. Electronic address: .
Wu M; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Jun 04; Vol. 78 (5), pp. 850-861.e5. Date of Electronic Publication: 2020 Apr 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Associated Proteins/*antagonists & inhibitors
CRISPR-Cas Systems/*physiology
RNA Editing/*physiology
Animals ; Bacteria/genetics ; Bacteriophages/genetics ; CRISPR-Associated Proteins/genetics ; CRISPR-Cas Systems/genetics ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Editing ; HEK293 Cells ; Humans ; Leptotrichia/genetics ; Leptotrichia/metabolism ; RNA/genetics ; RNA Editing/genetics
SCR Organism :
Leptotrichia buccalis
Czasopismo naukowe
Tytuł :
CRISPR/Cas9: A powerful genome editing technique for the treatment of cancer cells with present challenges and future directions.
Autorzy :
Hazafa A; Department of Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad 38000, Pakistan. Electronic address: .
Mumtaz M; Department of Chemistry, Faculty of Sciences, University of Agriculture, Faisalabad 38000, Pakistan.
Farooq MF; Department of Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad 38000, Pakistan.
Bilal S; Department of Agronomy, Faculty of Agriculture, University of Agriculture, Faisalabad 38000, Pakistan.
Chaudhry SN; Department of Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad 38000, Pakistan.
Firdous M; Department of Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad 38000, Pakistan.
Naeem H; Department of Computer Science, Faculty of Sciences, University of Agriculture, Faisalabad 38000, Pakistan.
Ullah MO; Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, Pakistan.
Yameen M; Department of Biochemistry, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan. Electronic address: .
Mukhtiar MS; Department of Biochemistry, Faculty of Sciences, University of Agriculture, Faisalabad 38000, Pakistan.
Zafar F; Institute of Biochemistry and Biotechnology, University of the Punjab, Lahore 54590, Pakistan.
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Źródło :
Life sciences [Life Sci] 2020 Dec 15; Vol. 263, pp. 118525. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
CRISPR-Cas Systems*
Gene Editing*
Genetic Therapy*
Genome, Human*
Neoplasms/*therapy
Humans ; Neoplasms/genetics ; Neoplasms/pathology
Czasopismo naukowe
Tytuł :
The application of a heat-inducible CRISPR/Cas12b (C2c1) genome editing system in tetraploid cotton (G. hirsutum) plants.
Autorzy :
Wang Q; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Alariqi M; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Wang F; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Li B; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Ding X; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Rui H; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Li Y; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Xu Z; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Qin L; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Sun L; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Li J; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Zou J; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Lindsey K; Department of Biosciences, Durham University, Durham, UK.
Zhang X; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
Jin S; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China.
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Źródło :
Plant biotechnology journal [Plant Biotechnol J] 2020 Dec; Vol. 18 (12), pp. 2436-2443. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems*
Gene Editing*
Clustered Regularly Interspaced Short Palindromic Repeats ; Genome, Plant ; Gossypium ; Hot Temperature ; Humans ; Plants, Genetically Modified/genetics ; Tetraploidy
Czasopismo naukowe
Tytuł :
[Current development of gene editing].
Autorzy :
Zhang D; College of Public Administration, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Luo Y; College of Public Administration, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Chen W; College of Public Administration, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
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Źródło :
Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Sheng Wu Gong Cheng Xue Bao] 2020 Nov 25; Vol. 36 (11), pp. 2345-2356.
Typ publikacji :
Journal Article
MeSH Terms :
CRISPR-Cas Systems*/genetics
Gene Editing*
China ; Clustered Regularly Interspaced Short Palindromic Repeats ; Plants/genetics
Czasopismo naukowe
Tytuł :
[Construction of seamless genome editing system for fast-growing Vibrio natriegens].
Autorzy :
Wu F; CAS Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Liang Y; CAS Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Zhang Y; CAS Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Huo Y; College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China.
Wang Q; CAS Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
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Źródło :
Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Sheng Wu Gong Cheng Xue Bao] 2020 Nov 25; Vol. 36 (11), pp. 2387-2397.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Editing*
Vibrio*/genetics
Plasmids/genetics ; Synthetic Biology
SCR Organism :
Vibrio natriegens
Czasopismo naukowe
Tytuł :
Towards precise, safe genome editing.
Autorzy :
Memczak S; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.; Paul F. Glenn Center for Biology of Aging Research at the Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Shao Y; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.; Universidad Católica San Antonio de Murcia (UCAM), Campus de los Jeronimos N135, 12, Guadalupe, CA, 30107, Spain.
Izpisua Belmonte JC; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA. .
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Źródło :
Cell research [Cell Res] 2019 Sep; Vol. 29 (9), pp. 687-689.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Clustered Regularly Interspaced Short Palindromic Repeats*
Gene Editing*
CRISPR-Cas Systems ; DNA ; RNA Editing ; Transcriptome
Czasopismo naukowe
Tytuł :
The final cut: Cas9 editing.
Autorzy :
Taylor DW; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA. .; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA. .; Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, TX, USA. .; LIVESTRONG Cancer Institutes, Dell Medical School, Austin, TX, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2019 Aug; Vol. 26 (8), pp. 669-670.
Typ publikacji :
Journal Article
MeSH Terms :
CRISPR-Cas Systems*
RNA Editing*
CRISPR-Associated Protein 9/*ultrastructure
CRISPR-Associated Protein 9/chemistry ; CRISPR-Associated Protein 9/metabolism ; Cryoelectron Microscopy ; DNA/metabolism ; DNA/ultrastructure ; Gene Editing/methods ; Macromolecular Substances/ultrastructure ; Models, Molecular ; Protein Conformation ; Streptococcus pyogenes/enzymology
Czasopismo naukowe
Tytuł :
Epigenome engineering: new technologies for precision medicine.
Autorzy :
Sgro A; Cancer Epigenetics Laboratory, The Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia.; School of Human Sciences, The University of Western Australia, Crawley, Perth, Western Australia 6009, Australia.
Blancafort P; Cancer Epigenetics Laboratory, The Harry Perkins Institute of Medical Research, Nedlands, Western Australia 6009, Australia.; School of Human Sciences, The University of Western Australia, Crawley, Perth, Western Australia 6009, Australia.; The Greehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, TX 78229, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Dec 16; Vol. 48 (22), pp. 12453-12482.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Editing*
Chromatin/*genetics
DNA Methylation/*genetics
Epigenome/*genetics
CRISPR-Cas Systems/genetics ; Genetic Engineering ; Humans ; Precision Medicine/trends
Czasopismo naukowe
Tytuł :
Generation of universal and hypoimmunogenic human pluripotent stem cells.
Autorzy :
Ye Q; School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.; Center of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan, China.; Skeletal Biology Research Center, Department of Oral Maxillofacial Surgery, Massachusetts General Hospital & Harvard School of Dental Medicine, Boston, MA, USA.
Sung TC; School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.; Department of Chemical and Materials Engineering, National Central University, Taoyuan, Taiwan.
Yang JM; Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan, Taiwan.
Ling QD; Cathay Medical Research Institute, Cathay General Hospital, Taipei, Taiwan.
He Y; School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
Higuchi A; School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, China.; Department of Chemical and Materials Engineering, National Central University, Taoyuan, Taiwan.; Wenzhou Institute, University of Chinese Academy of Science, Wenzhou, China.; Department of Chemical Engineering and R&D Center for Membrane Technology, Chung Yuan Christian University, Taoyuan, Taiwan.; Center for Emergent Matter Science, Riken, Saitama, Japan.
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Źródło :
Cell proliferation [Cell Prolif] 2020 Dec; Vol. 53 (12), pp. e12946. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Gene Editing*
CRISPR-Cas Systems/*genetics
Killer Cells, Natural/*cytology
Pluripotent Stem Cells/*cytology
Family Characteristics ; Humans ; Stem Cell Transplantation/methods
Czasopismo naukowe
Tytuł :
MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits.
Autorzy :
Ma L; Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.
Ruan J; Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.
Song J; Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.
Wen L; Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.
Yang D; Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.
Zhao J; Research & Development, ATGC Inc., 100 E Lancaster Avenue, LIMR Building Lab129, Wynnewood, PA, 19096, USA.
Xia X; Research & Development, ATGC Inc., 100 E Lancaster Avenue, LIMR Building Lab129, Wynnewood, PA, 19096, USA.
Chen YE; Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA. .
Zhang J; Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA. .
Xu J; Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 27; Vol. 11 (1), pp. 6082. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Editing*
Gene Knock-In Techniques*
CRISPR-Associated Protein 9/*metabolism
INDEL Mutation/*genetics
Amino Acid Sequence ; CRISPR-Associated Protein 9/chemistry ; Cell Line ; Green Fluorescent Proteins/metabolism ; Humans ; Rad51 Recombinase/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
A Cas-embedding strategy for minimizing off-target effects of DNA base editors.
Autorzy :
Liu Y; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Zhou C; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Huang S; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Dang L; Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China.
Wei Y; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
He J; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhou Y; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Mao S; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Tao W; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhang Y; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Yang H; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. .
Huang X; School of Life Science and Technology, ShanghaiTech University, Shanghai, China. .
Chi T; School of Life Science and Technology, ShanghaiTech University, Shanghai, China. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 27; Vol. 11 (1), pp. 6073. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Editing*
CRISPR-Associated Proteins/*metabolism
DNA/*genetics
APOBEC Deaminases/metabolism ; Ampicillin Resistance/genetics ; Base Sequence ; Codon, Terminator/genetics ; Cytosine/metabolism ; DNA Transposable Elements/genetics ; Genetic Testing ; HEK293 Cells ; Humans ; Mutagenesis, Insertional/genetics
Czasopismo naukowe
Tytuł :
CRISPR based editing of SIV proviral DNA in ART treated non-human primates.
Autorzy :
Mancuso P; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500N. Broad Street, 7th Floor, Philadelphia, PA, 19140, USA.
Chen C; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500N. Broad Street, 7th Floor, Philadelphia, PA, 19140, USA.
Kaminski R; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500N. Broad Street, 7th Floor, Philadelphia, PA, 19140, USA.
Gordon J; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500N. Broad Street, 7th Floor, Philadelphia, PA, 19140, USA.
Liao S; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500N. Broad Street, 7th Floor, Philadelphia, PA, 19140, USA.
Robinson JA; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500N. Broad Street, 7th Floor, Philadelphia, PA, 19140, USA.
Smith MD; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500N. Broad Street, 7th Floor, Philadelphia, PA, 19140, USA.
Liu H; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500N. Broad Street, 7th Floor, Philadelphia, PA, 19140, USA.
Sariyer IK; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500N. Broad Street, 7th Floor, Philadelphia, PA, 19140, USA.
Sariyer R; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500N. Broad Street, 7th Floor, Philadelphia, PA, 19140, USA.
Peterson TA; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, 70433, USA.
Donadoni M; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500N. Broad Street, 7th Floor, Philadelphia, PA, 19140, USA.
Williams JB; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, 70433, USA.
Siddiqui S; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, 70433, USA.
Bunnell BA; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, 70433, USA.; Tulane Brain Institute, Tulane University, New Orleans, LA, 70118, USA.; Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA, 70112, USA.; Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA.
Ling B; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, 70433, USA. .; Department of Microbiology & Immunology, Tulane University School of Medicine, New Orleans, LA, 70112, USA. .; Texas Biomedical Research Institute, San Antonio, TX, 78227, USA. .
MacLean AG; Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, 70433, USA. .; Tulane Brain Institute, Tulane University, New Orleans, LA, 70118, USA. .; Department of Microbiology & Immunology, Tulane University School of Medicine, New Orleans, LA, 70112, USA. .
Burdo TH; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500N. Broad Street, 7th Floor, Philadelphia, PA, 19140, USA. .
Khalili K; Department of Neuroscience, Center for Neurovirology, Lewis Katz School of Medicine at Temple University, 3500N. Broad Street, 7th Floor, Philadelphia, PA, 19140, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 27; Vol. 11 (1), pp. 6065. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Editing*
Anti-Retroviral Agents/*pharmacology
CRISPR-Cas Systems/*genetics
DNA, Viral/*genetics
Proviruses/*genetics
Simian Immunodeficiency Virus/*genetics
Animals ; Base Sequence ; Cells, Cultured ; DNA, Viral/blood ; Genome, Viral ; Humans ; Lung/drug effects ; Lung/virology ; Lymph Nodes/drug effects ; Lymph Nodes/virology ; Macaca mulatta ; Proviruses/drug effects ; Simian Acquired Immunodeficiency Syndrome/blood ; Simian Acquired Immunodeficiency Syndrome/virology ; Spleen/pathology ; Spleen/virology ; Tissue Distribution ; Transgenes
Czasopismo naukowe
Tytuł :
Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking.
Autorzy :
Ferrari S; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.
Jacob A; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.; Milano-Bicocca University, Monza, Italy.
Beretta S; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Unali G; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.
Albano L; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Vavassori V; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.
Cittaro D; Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Lazarevic D; Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Brombin C; CUSSB-University Center for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy.
Cugnata F; CUSSB-University Center for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy.
Kajaste-Rudnitski A; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Merelli I; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.; National Research Council, Institute for Biomedical Technologies, Segrate, Italy.
Genovese P; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy.; Gene Therapy Program, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Department of Pediatric Oncology, Harvard Medical School, Boston, MA, USA.
Naldini L; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Milan, Italy. .; Vita-Salute San Raffaele University, Milan, Italy. .
Pokaż więcej
Źródło :
Nature biotechnology [Nat Biotechnol] 2020 Nov; Vol. 38 (11), pp. 1298-1308. Date of Electronic Publication: 2020 Jun 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Tracking*
Gene Editing*
Hematopoietic Stem Cells/*cytology
Animals ; Base Sequence ; Cell Lineage ; Clone Cells ; Dependovirus/metabolism ; G2 Phase ; HEK293 Cells ; Humans ; Mice ; Recombinational DNA Repair ; Reproducibility of Results ; S Phase ; Transcription, Genetic ; Transplantation, Heterologous ; Tumor Suppressor Protein p53/metabolism ; Up-Regulation ; Viral Proteins/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
CRISPR/Cas13: A potential therapeutic option of COVID-19.
Autorzy :
Lotfi M; School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran; USERN Office, Zanjan University of Medical Sciences, Zanjan, Iran.
Rezaei N; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Nov; Vol. 131, pp. 110738. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
CRISPR-Cas Systems*
Gene Editing*
Betacoronavirus/*genetics
Coronavirus Infections/*therapy
Genetic Therapy/*methods
Pneumonia, Viral/*therapy
RNA, Viral/*genetics
Betacoronavirus/drug effects ; COVID-19 ; CRISPR-Associated Proteins/pharmacology ; Conserved Sequence ; Coronavirus Infections/drug therapy ; Coronavirus Infections/genetics ; Genome, Viral ; Humans ; Pandemics ; Pneumonia, Viral/genetics ; RNA, Guide/genetics ; RNA, Viral/antagonists & inhibitors ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe

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