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Wyszukujesz frazę ""Eichmüller SB"" wg kryterium: Autor


Wyświetlanie 1-18 z 18
Tytuł:
MicroRNAs affecting the susceptibility of melanoma cells to CD8 T cell-mediated cytolysis.
Autorzy:
Pane AA; Research Group GMP & T Cell Therapy, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany.
Kordaß T; Research Group GMP & T Cell Therapy, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Faculty of Biosciences, University of Heidelberg, Heidelberg, Germany.
Hotz-Wagenblatt A; Omics IT and Data Management Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Dickes E; Research Group GMP & T Cell Therapy, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kopp-Schneider A; Department of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Will R; Core Facility Cellular Tools, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Seliger B; Institute of Medical Immunology, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany.
Osen W; Research Group GMP & T Cell Therapy, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Eichmüller SB; Research Group GMP & T Cell Therapy, German Cancer Research Center (DKFZ), Heidelberg, Germany.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2023 Feb; Vol. 13 (2), pp. e1186.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
MicroRNAs*/genetics
MicroRNAs*/metabolism
Melanoma*/genetics
Humans ; Animals ; Mice ; RNA, Small Interfering ; CD8-Positive T-Lymphocytes/metabolism
Czasopismo naukowe
Tytuł:
Photon versus carbon ion irradiation: immunomodulatory effects exerted on murine tumor cell lines.
Autorzy:
Hartmann L; German Cancer Research Center (DKFZ), Research Group GMP & T Cell Therapy, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
Schröter P; German Cancer Research Center (DKFZ), Research Group GMP & T Cell Therapy, Heidelberg, Germany.; Department of Radiation Oncology, Heidelberg University Hospital (UKHD), Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany.; Department of Radiation Oncology, Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.
Osen W; German Cancer Research Center (DKFZ), Research Group GMP & T Cell Therapy, Heidelberg, Germany.
Baumann D; German Cancer Research Center (DKFZ), Molecular Oncology of Gastrointestinal Tumors, Heidelberg, Germany.; Department of Surgery, Heidelberg University Hospital (UKHD), Heidelberg, Germany.
Offringa R; German Cancer Research Center (DKFZ), Molecular Oncology of Gastrointestinal Tumors, Heidelberg, Germany.; Department of Surgery, Heidelberg University Hospital (UKHD), Heidelberg, Germany.
Moustafa M; Department of Radiation Oncology, Heidelberg University Hospital (UKHD), Heidelberg, Germany.; Faculty of Medicine Heidelberg (MFHD), Division of Molecular and Translational Radiation Oncology, Heidelberg, Germany.; German Cancer Consortium (DKTK) Core-Center Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt.
Will R; German Cancer Research Center (DKFZ), Genomics and Proteomics Core Facility, Heidelberg, Germany.
Debus J; Department of Radiation Oncology, Heidelberg University Hospital (UKHD), Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany.; Department of Radiation Oncology, Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.; Faculty of Medicine Heidelberg (MFHD), Division of Molecular and Translational Radiation Oncology, Heidelberg, Germany.; German Cancer Consortium (DKTK) Core-Center Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Brons S; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany.; Department of Radiation Oncology, Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital (UKHD), Heidelberg, Germany.
Rieken S; Department of Radiation Oncology, Heidelberg University Hospital (UKHD), Heidelberg, Germany. .; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany. .; Department of Radiation Oncology, Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital (UKHD), Heidelberg, Germany. .; Department of Radiation Oncology, University Medical Center Göttingen, Göttingen, Germany. .
Eichmüller SB; German Cancer Research Center (DKFZ), Research Group GMP & T Cell Therapy, Heidelberg, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2020 Dec 09; Vol. 10 (1), pp. 21517. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Heavy Ion Radiotherapy/*methods
Immunomodulation/*radiation effects
Photons/*therapeutic use
Animals ; Apoptosis/drug effects ; Carbon/pharmacology ; Cell Cycle Checkpoints/radiation effects ; Cell Line, Tumor ; Cell Survival/radiation effects ; Dose-Response Relationship, Radiation ; Humans ; Mice ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms
Czasopismo naukowe
Tytuł:
Reprogramming of macrophages employing gene regulatory and metabolic network models.
Autorzy:
Hörhold F; Center for Sepsis Control and Care, University Hospital, Jena, Germany.
Eisel D; Research Group GMP & T Cell Therapy, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Biopharmaceutical New Technologies (BioNTech) Corporation, Mainz, Germany.
Oswald M; Center for Sepsis Control and Care, University Hospital, Jena, Germany.
Kolte A; Center for Sepsis Control and Care, University Hospital, Jena, Germany.
Röll D; Center for Sepsis Control and Care, University Hospital, Jena, Germany.
Osen W; Research Group GMP & T Cell Therapy, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Eichmüller SB; Research Group GMP & T Cell Therapy, German Cancer Research Center (DKFZ), Heidelberg, Germany.
König R; Center for Sepsis Control and Care, University Hospital, Jena, Germany.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2020 Feb 25; Vol. 16 (2), pp. e1007657. Date of Electronic Publication: 2020 Feb 25 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Regulatory Networks*
Macrophage Activation*
Tumor Microenvironment*
Macrophages/*metabolism
Anaerobiosis ; Animals ; Cytokines/metabolism ; Gene Expression Profiling ; Gene Expression Regulation ; Glycolysis ; Immunosuppression Therapy ; Immunosuppressive Agents/therapeutic use ; Inosine Monophosphate/metabolism ; Mice ; Mice, Inbred C57BL ; Phenotype
Czasopismo naukowe
Tytuł:
Measles Vaccines Designed for Enhanced CD8 T Cell Activation.
Autorzy:
Busch E; National Center for Tumor Diseases (NCT), Department of Medical Oncology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Kubon KD; Clinical Cooperation Unit Virotherapy, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Medical Faculty, Heidelberg University, 69120 Heidelberg, Germany.
Mayer JKM; Clinical Cooperation Unit Virotherapy, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Medical Faculty, Heidelberg University, 69120 Heidelberg, Germany.
Pidelaserra-Martí G; Clinical Cooperation Unit Virotherapy, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Research Group Mechanisms of Oncolytic Immunotherapy, Clinical Cooperation Unit Virotherapy, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University and Helmholtz International Graduate School for Cancer Research, 69120 Heidelberg, Germany.
Albert J; National Center for Tumor Diseases (NCT), Department of Medical Oncology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; Clinical Cooperation Unit Virotherapy, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Hoyler B; National Center for Tumor Diseases (NCT), Department of Medical Oncology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; Clinical Cooperation Unit Virotherapy, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Heidbuechel JPW; National Center for Tumor Diseases (NCT), Department of Medical Oncology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; Clinical Cooperation Unit Virotherapy, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Research Group Mechanisms of Oncolytic Immunotherapy, Clinical Cooperation Unit Virotherapy, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Stephenson KB; McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4K1 Ontario, Canada.
Lichty BD; McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4K1 Ontario, Canada.
Osen W; Research Group GMP & T Cell Therapy, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Eichmüller SB; Research Group GMP & T Cell Therapy, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Jäger D; National Center for Tumor Diseases (NCT), Department of Medical Oncology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; Clinical Cooperation Unit Applied Tumor-Immunity, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Ungerechts G; National Center for Tumor Diseases (NCT), Department of Medical Oncology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; Clinical Cooperation Unit Virotherapy, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Center for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, K1H 8L6 Ontario, Canada.
Engeland CE; National Center for Tumor Diseases (NCT), Department of Medical Oncology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; Clinical Cooperation Unit Virotherapy, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Research Group Mechanisms of Oncolytic Immunotherapy, Clinical Cooperation Unit Virotherapy, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
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Źródło:
Viruses [Viruses] 2020 Feb 21; Vol. 12 (2). Date of Electronic Publication: 2020 Feb 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Vectors*
Lymphocyte Activation*
CD8-Positive T-Lymphocytes/*immunology
Measles Vaccine/*genetics
Measles Vaccine/*immunology
T-Lymphocytes, Cytotoxic/*immunology
Animals ; Antigen Presentation/immunology ; Antigens, Neoplasm/immunology ; Cell Line ; Epitopes, T-Lymphocyte/genetics ; Epitopes, T-Lymphocyte/immunology ; Interferon-gamma/immunology ; Interferon-gamma Release Tests ; Mice ; Mice, Inbred C57BL ; Ovalbumin/genetics ; Ovalbumin/immunology ; Proof of Concept Study ; Vaccines, Synthetic/immunology
Czasopismo naukowe
Tytuł:
Radiation-induced alterations in immunogenicity of a murine pancreatic ductal adenocarcinoma cell line.
Autorzy:
Schröter P; German Cancer Research Center (DKFZ), Research Group GMP & T Cell Therapy, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.; University Hospital Heidelberg, Department of Radiation Oncology, Im Neuenheimer Feld 400, D-69120, Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, D-69120, Heidelberg, Germany.
Hartmann L; German Cancer Research Center (DKFZ), Research Group GMP & T Cell Therapy, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.; Faculty of Biosciences, University Heidelberg, Heidelberg, Germany.
Osen W; German Cancer Research Center (DKFZ), Research Group GMP & T Cell Therapy, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.
Baumann D; German Cancer Research Center (DKFZ), Molecular Oncology of Gastrointestinal Tumors, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.; University Hospital Heidelberg, Department of Surgery, Im Neuenheimer Feld 110, D-69120, Heidelberg, Germany.
Offringa R; German Cancer Research Center (DKFZ), Molecular Oncology of Gastrointestinal Tumors, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.; University Hospital Heidelberg, Department of Surgery, Im Neuenheimer Feld 110, D-69120, Heidelberg, Germany.
Eisel D; German Cancer Research Center (DKFZ), Research Group GMP & T Cell Therapy, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.; Faculty of Biosciences, University Heidelberg, Heidelberg, Germany.; Biopharmaceutical New Technologies (BioNTech) Corporation, Mainz, Germany.
Debus J; University Hospital Heidelberg, Department of Radiation Oncology, Im Neuenheimer Feld 400, D-69120, Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, D-69120, Heidelberg, Germany.
Eichmüller SB; German Cancer Research Center (DKFZ), Research Group GMP & T Cell Therapy, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany. .
Rieken S; University Hospital Heidelberg, Department of Radiation Oncology, Im Neuenheimer Feld 400, D-69120, Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, D-69120, Heidelberg, Germany.
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Źródło:
Scientific reports [Sci Rep] 2020 Jan 20; Vol. 10 (1), pp. 686. Date of Electronic Publication: 2020 Jan 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
5'-Nucleotidase/*metabolism
B7-H1 Antigen/*metabolism
Carcinoma, Pancreatic Ductal/*immunology
Pancreatic Neoplasms/*immunology
Animals ; Carcinoma, Pancreatic Ductal/radiotherapy ; Cell Cycle/radiation effects ; Cell Line, Tumor ; Cell Proliferation/radiation effects ; Cell Survival/radiation effects ; Clone Cells/cytology ; Clone Cells/metabolism ; Clone Cells/radiation effects ; Dose-Response Relationship, Radiation ; Mice ; Pancreatic Neoplasms/radiotherapy ; Radiation Tolerance ; Time Factors
Czasopismo naukowe
Tytuł:
Correction: Generation of murine tumor cell lines deficient in MHC molecule surface expression using the CRISPR/Cas9 system.
Autorzy:
Das K
Eisel D
Lenkl C
Goyal A
Diederichs S
Dickes E
Osen W
Eichmüller SB
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Źródło:
PloS one [PLoS One] 2018 Dec 19; Vol. 13 (12), pp. e0209719. Date of Electronic Publication: 2018 Dec 19 (Print Publication: 2018).
Typ publikacji:
Journal Article; Published Erratum
Czasopismo naukowe
Tytuł:
Generation of murine tumor cell lines deficient in MHC molecule surface expression using the CRISPR/Cas9 system.
Autorzy:
Das K; GMP & T Cell Therapy Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Eisel D; GMP & T Cell Therapy Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Lenkl C; GMP & T Cell Therapy Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Goyal A; Division of RNA Biology and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Diederichs S; Division of RNA Biology and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Division of Cancer Research, Dept. of Thoracic Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg & German Cancer Consortium (DKTK), Freiburg, Germany.
Dickes E; GMP & T Cell Therapy Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Osen W; GMP & T Cell Therapy Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Eichmüller SB; GMP & T Cell Therapy Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
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Źródło:
PloS one [PLoS One] 2017 Mar 16; Vol. 12 (3), pp. e0174077. Date of Electronic Publication: 2017 Mar 16 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Clustered Regularly Interspaced Short Palindromic Repeats*
Major Histocompatibility Complex/*immunology
Animals ; Cell Line, Tumor ; Enzyme-Linked Immunosorbent Assay ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; beta 2-Microglobulin/genetics
Czasopismo naukowe
Tytuł:
Evaluation of the diagnostic value of 64 simultaneously measured autoantibodies for early detection of gastric cancer.
Autorzy:
Werner S; Division of Clinical Epidemiology and Aging Research, DKFZ, Heidelberg, Germany.
Chen H; Division of Clinical Epidemiology and Aging Research, DKFZ, Heidelberg, Germany.
Butt J; Division of Molecular Diagnostics of Oncogenic Infections, DKFZ, Heidelberg, Germany.
Michel A; Division of Molecular Diagnostics of Oncogenic Infections, DKFZ, Heidelberg, Germany.
Knebel P; Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Holleczek B; Saarland Cancer Registry, Saarbrücken, Germany.
Zörnig I; Department of Medical Oncology, National Center for Tumor Diseases (NCT) and Heidelberg University Hospital, Heidelberg, Germany.
Eichmüller SB; GMP &T cell Therapy Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jäger D; Department of Medical Oncology, National Center for Tumor Diseases (NCT) and Heidelberg University Hospital, Heidelberg, Germany.
Pawlita M; Division of Molecular Diagnostics of Oncogenic Infections, DKFZ, Heidelberg, Germany.
Waterboer T; Division of Molecular Diagnostics of Oncogenic Infections, DKFZ, Heidelberg, Germany.
Brenner H; Division of Clinical Epidemiology and Aging Research, DKFZ, Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
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Źródło:
Scientific reports [Sci Rep] 2016 May 03; Vol. 6, pp. 25467. Date of Electronic Publication: 2016 May 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antigens, Neoplasm/*blood
Membrane Proteins/*blood
Neoplasm Proteins/*blood
Stomach Neoplasms/*blood
Tumor Suppressor Protein p53/*blood
Adult ; Autoantibodies/genetics ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Early Detection of Cancer ; Female ; Humans ; Male ; Middle Aged ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology
Czasopismo naukowe
Tytuł:
SOX5 is involved in balanced MITF regulation in human melanoma cells.
Autorzy:
Kordaß T; GMP & T Cell Therapy Unit, German Cancer Research Center (DKFZ), INF 280, 69120, Heidelberg, Germany. .; Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Erlanger Allee 101, D-07747, Jena, Germany. .
Weber CE; GMP & T Cell Therapy Unit, German Cancer Research Center (DKFZ), INF 280, 69120, Heidelberg, Germany. .
Oswald M; Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Erlanger Allee 101, D-07747, Jena, Germany. .; Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Beutenbergstrasse 11a, 07745, Jena, Germany. .
Ast V; Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Erlanger Allee 101, D-07747, Jena, Germany. .; Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Beutenbergstrasse 11a, 07745, Jena, Germany. .
Bernhardt M; Skin Cancer Unit, German Cancer Research Center (DKFZ), INF 280, 69120, Heidelberg, Germany. .; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany. .
Novak D; Skin Cancer Unit, German Cancer Research Center (DKFZ), INF 280, 69120, Heidelberg, Germany. .; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany. .
Utikal J; Skin Cancer Unit, German Cancer Research Center (DKFZ), INF 280, 69120, Heidelberg, Germany. .; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany. .
Eichmüller SB; GMP & T Cell Therapy Unit, German Cancer Research Center (DKFZ), INF 280, 69120, Heidelberg, Germany. .
König R; Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Erlanger Allee 101, D-07747, Jena, Germany. .; Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Beutenbergstrasse 11a, 07745, Jena, Germany. .; Theoretical Bioinformatics, German Cancer Research Center, INF 580, 69121, Heidelberg, Germany. .
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Źródło:
BMC medical genomics [BMC Med Genomics] 2016 Feb 29; Vol. 9, pp. 10. Date of Electronic Publication: 2016 Feb 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Melanoma/*genetics
Melanoma/*pathology
Microphthalmia-Associated Transcription Factor/*genetics
SOXD Transcription Factors/*metabolism
Cell Line, Tumor ; Cell Survival/genetics ; Computer Simulation ; Fluorescence ; Gene Knockdown Techniques ; Green Fluorescent Proteins/metabolism ; Humans ; Microphthalmia-Associated Transcription Factor/metabolism ; Neoplasm Invasiveness ; Phenotype ; Programming, Linear ; RNA, Small Interfering/metabolism ; Reproducibility of Results ; SOXE Transcription Factors/metabolism ; Survival Analysis ; Transfection
Czasopismo naukowe
Tytuł:
miR-137 inhibits proliferation of melanoma cells by targeting PAK2.
Autorzy:
Hao S; Key Laboratory of Cell Proliferation and Regulation of Ministry of Education, Universities of the Confederated Institute for Proteomics, Beijing Normal University, Beijing, China.
Luo C; Department of Translational Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Abukiwan A; Department of Translational Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Wang G; Key Laboratory of Cell Proliferation and Regulation of Ministry of Education, Universities of the Confederated Institute for Proteomics, Beijing Normal University, Beijing, China.
He J; Key Laboratory of Cell Proliferation and Regulation of Ministry of Education, Universities of the Confederated Institute for Proteomics, Beijing Normal University, Beijing, China.
Huang L; Key Laboratory of Cell Proliferation and Regulation of Ministry of Education, Universities of the Confederated Institute for Proteomics, Beijing Normal University, Beijing, China.
Weber CE; Department of Translational Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Lv N; Key Laboratory of Cell Proliferation and Regulation of Ministry of Education, Universities of the Confederated Institute for Proteomics, Beijing Normal University, Beijing, China.
Xiao X; Key Laboratory of Cell Proliferation and Regulation of Ministry of Education, Universities of the Confederated Institute for Proteomics, Beijing Normal University, Beijing, China.
Eichmüller SB; Department of Translational Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
He D; Key Laboratory of Cell Proliferation and Regulation of Ministry of Education, Universities of the Confederated Institute for Proteomics, Beijing Normal University, Beijing, China.
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Źródło:
Experimental dermatology [Exp Dermatol] 2015 Dec; Vol. 24 (12), pp. 947-52. Date of Electronic Publication: 2015 Aug 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Melanoma/*genetics
Melanoma/*pathology
MicroRNAs/*genetics
p21-Activated Kinases/*antagonists & inhibitors
p21-Activated Kinases/*genetics
Apoptosis/genetics ; Apoptosis/physiology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cell Proliferation/physiology ; Down-Regulation ; Gene Knockdown Techniques ; Humans ; Melanoma/metabolism ; MicroRNAs/metabolism ; RNA, Neoplasm/genetics ; RNA, Neoplasm/metabolism ; RNA, Small Interfering/genetics ; Transfection ; p21-Activated Kinases/metabolism
Czasopismo naukowe
Tytuł:
Knockdown of lecithin retinol acyltransferase increases all-trans retinoic acid levels and restores retinoid sensitivity in malignant melanoma cells.
Autorzy:
Amann PM; Department of Dermatology and Allergology, RWTH Aachen University, Aachen, Germany.
Czaja K
Bazhin AV
Rühl R
Skazik C
Heise R
Marquardt Y
Eichmüller SB
Merk HF
Baron JM
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Źródło:
Experimental dermatology [Exp Dermatol] 2014 Nov; Vol. 23 (11), pp. 832-7. Date of Electronic Publication: 2014 Oct 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acyltransferases/*genetics
Melanoma/*metabolism
Skin Neoplasms/*metabolism
Tretinoin/*chemistry
Catalysis ; Cell Line, Tumor ; Cells, Cultured ; Disease Progression ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Keratinocytes/cytology ; Melanocytes/metabolism ; Vitamin A/chemistry ; Melanoma, Cutaneous Malignant
Czasopismo naukowe
Tytuł:
A vaccine targeting mutant IDH1 induces antitumour immunity.
Autorzy:
Schumacher T; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [3].
Bunse L; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [3].
Pusch S; 1] Department of Neuropathology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Sahm F; 1] Department of Neuropathology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Wiestler B; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Quandt J; Department of Translational Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Menn O; Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany.
Osswald M; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Oezen I; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Ott M; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Keil M; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Balß J; 1] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Rauschenbach K; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Grabowska AK; Department of Immunotherapy and -prevention Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Vogler I; Ribological GmbH, 55131 Mainz, Germany.
Diekmann J; Translational Oncology, 55131 Mainz, Germany.
Trautwein N; Department of Immunology, University of Tübingen, 72076 Tübingen, Germany.
Eichmüller SB; Department of Translational Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Okun J; Metabolic Centre Heidelberg, University Children's Hospital, 69120 Heidelberg, Germany.
Stevanović S; Department of Immunology, University of Tübingen, 72076 Tübingen, Germany.
Riemer AB; Department of Immunotherapy and -prevention Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Sahin U; Translational Oncology, 55131 Mainz, Germany.
Friese MA; Center for Molecular Neurobiology, University Medical Center, Hamburg-Eppendorf, 20251 Hamburg, Germany.
Beckhove P; Department of Translational Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
von Deimling A; 1] Department of Neuropathology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Wick W; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Platten M; 1] Department of Neurooncology, University Hospital Heidelberg and National Center for Tumor Diseases, 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK) Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
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Źródło:
Nature [Nature] 2014 Aug 21; Vol. 512 (7514), pp. 324-7. Date of Electronic Publication: 2014 Jun 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cancer Vaccines/*immunology
Cancer Vaccines/*therapeutic use
Glioma/*immunology
Glioma/*therapy
Isocitrate Dehydrogenase/*genetics
Isocitrate Dehydrogenase/*immunology
Mutant Proteins/*immunology
Animals ; Antibody Specificity ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/immunology ; Female ; Glioma/enzymology ; Glioma/genetics ; Histocompatibility Antigens Class II/immunology ; Humans ; Immunity, Humoral ; Immunotherapy/methods ; Male ; Mice ; Mutant Proteins/genetics ; Mutation ; T-Lymphocytes, Helper-Inducer/immunology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Lecithin retinol acyltransferase as a potential prognostic marker for malignant melanoma.
Autorzy:
Hassel JC; Skin Cancer Unit, German Cancer Research Centre (DKFZ), Heidelberg, Germany; Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.
Amann PM
Schadendorf D
Eichmüller SB
Nagler M
Bazhin AV
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Źródło:
Experimental dermatology [Exp Dermatol] 2013 Nov; Vol. 22 (11), pp. 757-9.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acyltransferases/*metabolism
Biomarkers, Tumor/*metabolism
Melanoma/*diagnosis
Skin Neoplasms/*diagnosis
Adult ; Aged ; Aged, 80 and over ; Cell Cycle ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Male ; Melanocytes/cytology ; Melanoma/metabolism ; Middle Aged ; Neoplasm Metastasis ; Prognosis ; Skin Neoplasms/metabolism ; Treatment Outcome ; Vitamin A/chemistry ; cis-trans-Isomerases/metabolism
Czasopismo naukowe
Tytuł:
Retinal and retinol are potential regulators of gene expression in the keratinocyte cell line HaCaT.
Autorzy:
Amann PM
Schadendorf D
Owen RW
Korn B
Eichmüller SB
Bazhin AV
Pokaż więcej
Źródło:
Experimental dermatology [Exp Dermatol] 2011 Apr; Vol. 20 (4), pp. 373-5. Date of Electronic Publication: 2010 Aug 31.
Typ publikacji:
Letter
MeSH Terms:
Gene Expression Regulation*
Retinaldehyde/*genetics
Vitamin A/*genetics
Humans ; Keratinocytes/metabolism ; Receptors, Retinoic Acid/genetics ; Receptors, Retinoic Acid/metabolism ; Retinaldehyde/metabolism ; Retinoid X Receptors/genetics ; Retinoid X Receptors/metabolism ; Transcription, Genetic ; Vitamin A/metabolism
Opinia redakcyjna
Tytuł:
Screening of human tumor antigens for CD4 T cell epitopes by combination of HLA-transgenic mice, recombinant adenovirus and antigen peptide libraries.
Autorzy:
Osen W; Clinical Cooperation for Unit Dermato-Oncology, German Cancer Research Center, Heidelberg, Germany.
Soltek S
Song M
Leuchs B
Steitz J
Tüting T
Eichmüller SB
Nguyen XD
Schadendorf D
Paschen A
Pokaż więcej
Źródło:
PloS one [PLoS One] 2010 Nov 30; Vol. 5 (11), pp. e14137. Date of Electronic Publication: 2010 Nov 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Peptide Library*
Antigens, Neoplasm/*immunology
CD4-Positive T-Lymphocytes/*immunology
Epitopes, T-Lymphocyte/*immunology
Adenoviridae/genetics ; Animals ; Antigens/genetics ; Antigens/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Flow Cytometry ; HEK293 Cells ; HLA-DR Antigens/genetics ; HLA-DR Antigens/immunology ; HLA-DRB1 Chains ; Humans ; Immunization/methods ; Immunophenotyping ; Interferon-gamma/immunology ; Interferon-gamma/metabolism ; Melanoma/immunology ; Melanoma/pathology ; Mice ; Mice, Transgenic ; Spleen/immunology ; Spleen/metabolism
Czasopismo naukowe
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