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    Wyświetlanie 1-7 z 7
    Tytuł:
    Time-resolved spectroscopic and electrophysiological data reveal insights in the gating mechanism of anion channelrhodopsin.
    Autorzy:
    Dreier MA; Biospectroscopy, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany.; Department of Biophysics, Ruhr University Bochum, Bochum, Germany.
    Althoff P; Biospectroscopy, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany.; Department of Biophysics, Ruhr University Bochum, Bochum, Germany.
    Norahan MJ; Biospectroscopy, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany.; Department of Biophysics, Ruhr University Bochum, Bochum, Germany.
    Tennigkeit SA; Biospectroscopy, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany.; Department of Biophysics, Ruhr University Bochum, Bochum, Germany.
    El-Mashtoly SF; Biospectroscopy, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany.; Department of Biophysics, Ruhr University Bochum, Bochum, Germany.
    Lübben M; Biospectroscopy, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany.; Department of Biophysics, Ruhr University Bochum, Bochum, Germany.
    Kötting C; Biospectroscopy, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany.; Department of Biophysics, Ruhr University Bochum, Bochum, Germany.
    Rudack T; Biospectroscopy, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany. .; Department of Biophysics, Ruhr University Bochum, Bochum, Germany. .
    Gerwert K; Biospectroscopy, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany. .; Department of Biophysics, Ruhr University Bochum, Bochum, Germany. .
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    Źródło:
    Communications biology [Commun Biol] 2021 May 14; Vol. 4 (1), pp. 578. Date of Electronic Publication: 2021 May 14.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Electrophysiological Phenomena*
    Ion Channel Gating*
    Anions/*chemistry
    Channelrhodopsins/*physiology
    Cryptophyta/*physiology
    Light ; Optogenetics ; Spectrophotometry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Label-free vibrational imaging of different Aβ plaque types in Alzheimer's disease reveals sequential events in plaque development.
    Autorzy:
    Röhr D; Division of Biospectroscopy, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany.; Department of Biophysics, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
    Boon BDC; Department of Pathology, Amsterdam Neuroscience, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands.; Department of Neurology, Amsterdam Neuroscience, Alzheimer Center Amsterdam, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands.
    Schuler M; Division of Biospectroscopy, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany.; Department of Biophysics, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
    Kremer K; Division of Biospectroscopy, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany.; Department of Biophysics, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
    Hoozemans JJM; Department of Pathology, Amsterdam Neuroscience, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands.
    Bouwman FH; Department of Neurology, Amsterdam Neuroscience, Alzheimer Center Amsterdam, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands.
    El-Mashtoly SF; Division of Biospectroscopy, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany.; Department of Biophysics, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
    Nabers A; Division of Biospectroscopy, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany.; Department of Biophysics, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
    Großerueschkamp F; Division of Biospectroscopy, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany.; Department of Biophysics, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
    Rozemuller AJM; Department of Pathology, Amsterdam Neuroscience, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands.
    Gerwert K; Division of Biospectroscopy, Center for Protein Diagnostics (PRODI), Ruhr University Bochum, Bochum, Germany. .; Department of Biophysics, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany. .
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    Źródło:
    Acta neuropathologica communications [Acta Neuropathol Commun] 2020 Dec 11; Vol. 8 (1), pp. 222. Date of Electronic Publication: 2020 Dec 11.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Alzheimer Disease/*diagnostic imaging
    Amyloid beta-Peptides/*metabolism
    Plaque, Amyloid/*diagnostic imaging
    Aged ; Aged, 80 and over ; Alzheimer Disease/metabolism ; Disease Progression ; Female ; Humans ; Male ; Plaque, Amyloid/classification ; Plaque, Amyloid/metabolism ; Spectroscopy, Fourier Transform Infrared ; Spectrum Analysis, Raman
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Raman micro-spectroscopy monitors acquired resistance to targeted cancer therapy at the cellular level.
    Autorzy:
    Hammoud MK; Department of Biophysics, Ruhr-University Bochum, 44780, Bochum, Germany.
    Yosef HK; Department of Biophysics, Ruhr-University Bochum, 44780, Bochum, Germany.
    Lechtonen T; Department of Biophysics, Ruhr-University Bochum, 44780, Bochum, Germany.
    Aljakouch K; Department of Biophysics, Ruhr-University Bochum, 44780, Bochum, Germany.
    Schuler M; Department of Biophysics, Ruhr-University Bochum, 44780, Bochum, Germany.
    Alsaidi W; Department of Biophysics, Ruhr-University Bochum, 44780, Bochum, Germany.
    Daho I; Department of Biophysics, Ruhr-University Bochum, 44780, Bochum, Germany.
    Maghnouj A; Department of Molecular GI-Oncology, Clinical Research Center, Ruhr-University Bochum, 44780, Bochum, Germany.
    Hahn S; Department of Molecular GI-Oncology, Clinical Research Center, Ruhr-University Bochum, 44780, Bochum, Germany.
    El-Mashtoly SF; Department of Biophysics, Ruhr-University Bochum, 44780, Bochum, Germany. .
    Gerwert K; Department of Biophysics, Ruhr-University Bochum, 44780, Bochum, Germany.
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    Źródło:
    Scientific reports [Sci Rep] 2018 Oct 15; Vol. 8 (1), pp. 15278. Date of Electronic Publication: 2018 Oct 15.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Resistance, Neoplasm*/genetics
    Spectrum Analysis, Raman*/methods
    Carcinoma, Non-Small-Cell Lung/*drug therapy
    Drug Monitoring/*methods
    Lung Neoplasms/*drug therapy
    Protein Kinase Inhibitors/*therapeutic use
    Amino Acid Substitution ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/genetics ; Drug Screening Assays, Antitumor ; ErbB Receptors/genetics ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Molecular Targeted Therapy ; Precision Medicine ; Treatment Outcome ; Tumor Cells, Cultured
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    In vitro prediction of the efficacy of molecularly targeted cancer therapy by Raman spectral imaging.
    Autorzy:
    Yosef HK; Department of Biophysics, Ruhr University Bochum, Universitätsstr. 150, 44780, Bochum, Germany.
    Mavarani L; Department of Biophysics, Ruhr University Bochum, Universitätsstr. 150, 44780, Bochum, Germany.
    Maghnouj A; Department of Molecular GI-Oncology, Clinical Research Center, Ruhr University Bochum, Universitätsstr. 150, 44780, Bochum, Germany.
    Hahn S; Department of Molecular GI-Oncology, Clinical Research Center, Ruhr University Bochum, Universitätsstr. 150, 44780, Bochum, Germany.
    El-Mashtoly SF; Department of Biophysics, Ruhr University Bochum, Universitätsstr. 150, 44780, Bochum, Germany.
    Gerwert K; Department of Biophysics, Ruhr University Bochum, Universitätsstr. 150, 44780, Bochum, Germany. .
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    Źródło:
    Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2015 Nov; Vol. 407 (27), pp. 8321-31. Date of Electronic Publication: 2015 Jul 14.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Resistance, Neoplasm*
    Antineoplastic Agents/*pharmacology
    Colon/*pathology
    Colonic Neoplasms/*drug therapy
    ErbB Receptors/*antagonists & inhibitors
    Erlotinib Hydrochloride/*pharmacology
    Spectrum Analysis, Raman/*methods
    Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Colon/drug effects ; Colon/metabolism ; Colonic Neoplasms/genetics ; Colonic Neoplasms/pathology ; Erlotinib Hydrochloride/therapeutic use ; HT29 Cells ; Humans ; Microscopy, Confocal/methods ; Molecular Targeted Therapy ; Mutation ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins p21(ras)/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-7 z 7

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