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Wyszukujesz frazę ""Electron Transport Complex III"" wg kryterium: Temat


Tytuł :
Cryo-EM structures of engineered active bc 1 -cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes.
Autorzy :
Steimle S; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.
van Eeuwen T; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ozturk Y; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.; Institute of Biochemistry and Molecular Biology, Faculty of Medicine, Albert-Ludwigs University of Freiburg, Freiburg, Germany.
Kim HJ; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Braitbard M; School of Computer Science and Engineering, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
Selamoglu N; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Garcia BA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Schneidman-Duhovny D; School of Computer Science and Engineering, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
Murakami K; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. .
Daldal F; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 10; Vol. 12 (1), pp. 929. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*chemistry
Bacterial Proteins/*metabolism
Electron Transport Complex III/*chemistry
Electron Transport Complex III/*metabolism
Electron Transport Complex IV/*chemistry
Electron Transport Complex IV/*metabolism
Rhodobacter capsulatus/*enzymology
Bacterial Proteins/genetics ; Catalytic Domain ; Coenzymes/chemistry ; Coenzymes/metabolism ; Cryoelectron Microscopy ; Electron Transport ; Electron Transport Complex III/genetics ; Electron Transport Complex IV/genetics ; Genetic Engineering ; Rhodobacter capsulatus/chemistry ; Rhodobacter capsulatus/genetics ; Rhodobacter capsulatus/metabolism
Czasopismo naukowe
Tytuł :
Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction.
Autorzy :
Peruzzo R; Department of Biology, University of Padova, Padova, Italy.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
Corrà S; Department of Biology, University of Padova, Padova, Italy.
Costa R; Department of Biology, University of Padova, Padova, Italy.
Brischigliaro M; Department of Biology, University of Padova, Padova, Italy.
Varanita T; Department of Biology, University of Padova, Padova, Italy.
Biasutto L; CNR Institute of Neuroscience, Padova, Italy.; Department of Biomedical Sciences, University of Padova, Padova, Italy.
Rampazzo C; Department of Biology, University of Padova, Padova, Italy.
Ghezzi D; Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Leanza L; Department of Biology, University of Padova, Padova, Italy.
Zoratti M; CNR Institute of Neuroscience, Padova, Italy.; Department of Biomedical Sciences, University of Padova, Padova, Italy.
Zeviani M; Department of Neurosciences, University of Padova, Padova, Italy.; Venetian Institute of Molecular Medicine, Padova, Italy.
De Pittà C; Department of Biology, University of Padova, Padova, Italy.
Viscomi C; Department of Biomedical Sciences, University of Padova, Padova, Italy.
Costa R; Department of Biology, University of Padova, Padova, Italy.
Szabò I; Department of Biology, University of Padova, Padova, Italy. .; CNR Institute of Neuroscience, Padova, Italy. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 08; Vol. 12 (1), pp. 2103. Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Triphosphate/*biosynthesis
Electron Transport Complex III/*metabolism
Membrane Proteins/*genetics
Mitochondrial Diseases/*drug therapy
Mitochondrial Proteins/*genetics
Pyocyanine/*pharmacology
ATPases Associated with Diverse Cellular Activities/genetics ; Animals ; Animals, Genetically Modified ; Cell Line ; Drosophila melanogaster ; Electron Transport Complex III/genetics ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Membrane Potential, Mitochondrial/physiology ; Mice ; Mitochondrial Diseases/pathology ; Molecular Chaperones/genetics ; Oxidation-Reduction/drug effects ; Pyocyanine/metabolism ; Reactive Oxygen Species/metabolism ; Zebrafish
Czasopismo naukowe
Tytuł :
Effect of mitochondrial complex III inhibitors on the regulation of vascular tone in porcine coronary artery.
Autorzy :
Saarti M; School of Life Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK.
Almukhtar H; School of Life Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK.
Smith PA; School of Life Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK.
Roberts RE; School of Life Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Apr 05; Vol. 896, pp. 173917. Date of Electronic Publication: 2021 Jan 30.
Typ publikacji :
Journal Article
MeSH Terms :
Antimycin A/*pharmacology
Coronary Vessels/*drug effects
Electron Transport Complex III/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Mitochondria/*drug effects
Vasoconstriction/*drug effects
AMP-Activated Protein Kinases/metabolism ; Animals ; Calcium Signaling ; Coronary Vessels/enzymology ; Electron Transport Complex III/metabolism ; Female ; In Vitro Techniques ; Male ; Methacrylates/pharmacology ; Mitochondria/enzymology ; Phosphorylation ; Sus scrofa ; Thiazoles/pharmacology
Czasopismo naukowe
Tytuł :
Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex in Toxoplasma gondii parasites.
Autorzy :
Hayward JA; Research School of Biology, Australian National University, Canberra, Australia.
Rajendran E; Research School of Biology, Australian National University, Canberra, Australia.
Zwahlen SM; Research School of Biology, Australian National University, Canberra, Australia.
Faou P; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.
van Dooren GG; Research School of Biology, Australian National University, Canberra, Australia.
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Źródło :
PLoS pathogens [PLoS Pathog] 2021 Feb 01; Vol. 17 (2), pp. e1009211. Date of Electronic Publication: 2021 Feb 01 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Electron Transport Complex III/*metabolism
Toxoplasma/*metabolism
Animals ; Blotting, Western ; Cells, Cultured ; Electron Transport Complex III/chemistry ; Fluorescent Antibody Technique ; Humans ; Mitochondria/metabolism ; Oxygen/metabolism ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Smegmamorpha ; Toxoplasma/genetics
Czasopismo naukowe
Tytuł :
Artesunate alleviates schistosomiasis-induced liver fibrosis by downregulation of mitochondrial complex Ⅰ subunit NDUFB8 and complex Ⅲ subunit UQCRC2 in hepatic stellate cells.
Autorzy :
Shen S; Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China; Central laboratory, Shanghai Sixth People's Hospital East Campus, Shanghai University of Medicine & Health Sciences, Shanghai, China. Electronic address: .
Luo J; Central laboratory, Shanghai Sixth People's Hospital East Campus, Shanghai University of Medicine & Health Sciences, Shanghai, China; National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, China.
Ye J; Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China; Central laboratory, Shanghai Sixth People's Hospital East Campus, Shanghai University of Medicine & Health Sciences, Shanghai, China.
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Źródło :
Acta tropica [Acta Trop] 2021 Feb; Vol. 214, pp. 105781. Date of Electronic Publication: 2020 Nov 29.
Typ publikacji :
Journal Article
MeSH Terms :
Artesunate/*therapeutic use
Electron Transport Complex I/*metabolism
Electron Transport Complex III/*metabolism
Hepatic Stellate Cells/*drug effects
Liver Cirrhosis/*drug therapy
Liver Cirrhosis/*etiology
Animals ; Apoptosis/drug effects ; Cell Line ; Down-Regulation/drug effects ; Electron Transport Complex I/genetics ; Electron Transport Complex I/therapeutic use ; Electron Transport Complex III/genetics ; Gene Expression Regulation/drug effects ; Hepatic Stellate Cells/metabolism ; Mice ; Mitochondria/metabolism ; Schistosomiasis/pathology
Czasopismo naukowe
Tytuł :
Hypoxia Promotes Mitochondrial Complex I Abundance via HIF-1α in Complex III and Complex IV Eficient Cells.
Autorzy :
Saldana-Caboverde A; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Nissanka N; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Garcia S; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Lombès A; Institut Cochin, Unité U1016, INSERM, UMR 8104, CNRS, Université Paris 5, F-75014 Paris, France.
Diaz F; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
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Źródło :
Cells [Cells] 2020 Sep 29; Vol. 9 (10). Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Electron Transport Complex I/*metabolism
Electron Transport Complex III/*metabolism
Electron Transport Complex IV/*metabolism
Fibroblasts/*metabolism
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Mitochondria/*metabolism
Alkyl and Aryl Transferases/genetics ; Alkyl and Aryl Transferases/metabolism ; Animals ; Cell Hypoxia/genetics ; Cell Line ; Cytochrome-c Oxidase Deficiency/metabolism ; Doxycycline/pharmacology ; Electron Transport Complex III/deficiency ; Electron Transport Complex III/genetics ; Electron Transport Complex IV/genetics ; Gene Knockout Techniques ; Gene Silencing ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; RNA, Small Interfering ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
The cytochrome bc 1 complex as an antipathogenic target.
Autorzy :
Fisher N; MSU-DOE Plant Research Laboratory, Michigan State University, East Lansing, MI, USA.
Meunier B; CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, Gif-sur-Yvette, France.
Biagini GA; Parasitology Department, Research Centre for Drugs & Diagnostics, Liverpool School of Tropical Medicine, Liverpool, UK.
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Źródło :
FEBS letters [FEBS Lett] 2020 Sep; Vol. 594 (18), pp. 2935-2952. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Electron Transport Complex III*/antagonists & inhibitors
Electron Transport Complex III*/metabolism
Fungal Proteins*/antagonists & inhibitors
Fungal Proteins*/metabolism
Malaria, Falciparum*/drug therapy
Malaria, Falciparum*/enzymology
Protozoan Proteins*/antagonists & inhibitors
Protozoan Proteins*/metabolism
Antifungal Agents/*pharmacology
Antimalarials/*therapeutic use
Fungi/*enzymology
Plant Diseases/*microbiology
Plasmodium falciparum/*enzymology
Humans
Czasopismo naukowe
Tytuł :
N-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)picolinamide as a new inhibitor of mitochondrial complex III: Synthesis, biological evaluation and computational simulations.
Autorzy :
Cheng H; Department of Chemical Engineering and Food Science, Hubei University of Arts and Science, Xiangyang 441053, PR China.
Yang L; Department of Chemical Engineering and Food Science, Hubei University of Arts and Science, Xiangyang 441053, PR China.
Liu HF; Department of Chemical Engineering and Food Science, Hubei University of Arts and Science, Xiangyang 441053, PR China.
Zhang R; Department of Chemical Engineering and Food Science, Hubei University of Arts and Science, Xiangyang 441053, PR China. Electronic address: .
Chen C; State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, PR China. Electronic address: .
Wu Y; Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, PR China.
Jiang W; Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, PR China.
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Aug 15; Vol. 30 (16), pp. 127302. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Dynamics Simulation*
Electron Transport Complex III/*antagonists & inhibitors
Picolinic Acids/*pharmacology
Dose-Response Relationship, Drug ; Electron Transport Complex III/deficiency ; Electron Transport Complex III/metabolism ; Humans ; Mitochondrial Diseases ; Molecular Structure ; Picolinic Acids/chemical synthesis ; Picolinic Acids/chemistry ; Structure-Activity Relationship
SCR Disease Name :
Mitochondrial Complex III Deficiency
Czasopismo naukowe
Tytuł :
Glutathionylated and Fe-S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain.
Autorzy :
Thiriveedi VR; Department of Biochemistry, University of Hyderabad, Gachibowli, Hyderabad, TS, 500046, India.
Mattam U; Department of Biochemistry, University of Hyderabad, Gachibowli, Hyderabad, TS, 500046, India.
Pattabhi P; Department of Biochemistry, University of Hyderabad, Gachibowli, Hyderabad, TS, 500046, India.
Bisoyi V; Department of Biochemistry, University of Hyderabad, Gachibowli, Hyderabad, TS, 500046, India.
Talari NK; Department of Biochemistry, University of Hyderabad, Gachibowli, Hyderabad, TS, 500046, India.
Krishnamoorthy T; Vectrogen Biologicals Pvt.Ltd., BioNEST, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, TS, 500046, India.
Sepuri NBV; Department of Biochemistry, University of Hyderabad, Gachibowli, Hyderabad, TS, 500046, India. Electronic address: .
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Źródło :
Redox biology [Redox Biol] 2020 Oct; Vol. 37, pp. 101725. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Electron Transport Complex III*
Electron Transport Complex IV*
Mitochondrial Membrane Transport Proteins*/genetics
Mitochondrial Membrane Transport Proteins*/metabolism
Electron Transport ; HEK293 Cells ; Humans ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Oxidation-Reduction ; Protein Transport ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
UQCRH downregulation promotes Warburg effect in renal cell carcinoma cells.
Autorzy :
Luo Y; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame, 193 Galvin Life Sciences Center, Notre Dame, IN, 46556, USA.; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA.
Medina Bengtsson L; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame, 193 Galvin Life Sciences Center, Notre Dame, IN, 46556, USA.; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA.
Wang X; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame, 193 Galvin Life Sciences Center, Notre Dame, IN, 46556, USA.; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA.
Huang T; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame, 193 Galvin Life Sciences Center, Notre Dame, IN, 46556, USA.; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA.
Liu G; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame, 193 Galvin Life Sciences Center, Notre Dame, IN, 46556, USA.; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA.; Integrated Biomedical Sciences Graduate Program, Warren Family Research Center for Drug Discovery and Development, University of Notre Dame, Notre Dame, IN, 46556, USA.
Murphy S; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame, 193 Galvin Life Sciences Center, Notre Dame, IN, 46556, USA.; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA.
Wang C; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame, 193 Galvin Life Sciences Center, Notre Dame, IN, 46556, USA.; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA.
Koren J 3rd; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, USA.
Schafer Z; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame, 193 Galvin Life Sciences Center, Notre Dame, IN, 46556, USA.; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA.
Lu X; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame, 193 Galvin Life Sciences Center, Notre Dame, IN, 46556, USA. .; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA. .; Integrated Biomedical Sciences Graduate Program, Warren Family Research Center for Drug Discovery and Development, University of Notre Dame, Notre Dame, IN, 46556, USA. .; Tumor Microenvironment and Metastasis Program, Bren Simon Cancer Center, Indiana University Melvin, Indianapolis, IN, 46202, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Sep 14; Vol. 10 (1), pp. 15021. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Warburg Effect, Oncologic*
Carcinoma, Renal Cell/*metabolism
Electron Transport Complex III/*genetics
Kidney Neoplasms/*metabolism
Animals ; Apoptosis ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/pathology ; Cell Line, Tumor ; DNA Methylation ; Down-Regulation ; Electron Transport Complex III/metabolism ; Humans ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Male ; Mice
Czasopismo naukowe
Tytuł :
Ubiquinol-cytochrome c reductase core protein 1 overexpression protects H9c2 cardiac cells against mimic ischemia/reperfusion injury through PI3K/Akt/GSK-3β pathway.
Autorzy :
Yi T; Department of Anesthesiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China; Department of Anesthesiology, Yongchuan Hospital, Chongqing Medical University, Chongqing, 402160, China.
Wu X; Department of Anesthesiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China; Department of Intensive Care Unit, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, 610072, China.
Li H; Department of Anesthesiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Sep 03; Vol. 529 (4), pp. 904-909. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Electron Transport Complex III/*genetics
Glycogen Synthase Kinase 3 beta/*genetics
Myocytes, Cardiac/*metabolism
Oxygen/*pharmacology
Phosphatidylinositol 3-Kinases/*genetics
Proto-Oncogene Proteins c-akt/*genetics
Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Caspase 3/genetics ; Caspase 3/metabolism ; Cell Line ; Chromones/pharmacology ; Electron Transport Complex III/metabolism ; Embryo, Mammalian ; Gene Expression Regulation ; Glucose/deficiency ; Glucose/pharmacology ; Glycogen Synthase Kinase 3 beta/metabolism ; Hydrogen Peroxide/pharmacology ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Models, Biological ; Morpholines/pharmacology ; Myocardial Reperfusion Injury/genetics ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/pathology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Signal Transduction ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Design and synthesis of potent inhibitors of bc 1 complex based on natural product neopeltolide.
Autorzy :
Xiong MQ; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Chemical Biology Center, Central China Normal University, Wuhan 430079, PR China.
Chen T; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Chemical Biology Center, Central China Normal University, Wuhan 430079, PR China.
Wang YX; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Chemical Biology Center, Central China Normal University, Wuhan 430079, PR China.
Zhu XL; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Chemical Biology Center, Central China Normal University, Wuhan 430079, PR China. Electronic address: .
Yang GF; Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Chemical Biology Center, Central China Normal University, Wuhan 430079, PR China; Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, PR China. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Aug 15; Vol. 30 (16), pp. 127324. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Biological Products/*pharmacology
Electron Transport Complex III/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Macrolides/*pharmacology
Animals ; Biological Products/chemistry ; Biological Products/isolation & purification ; Dose-Response Relationship, Drug ; Electron Transport Complex III/metabolism ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/isolation & purification ; Macrolides/chemistry ; Macrolides/isolation & purification ; Molecular Docking Simulation ; Molecular Structure ; Porifera/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Complex III Inhibition-Induced Pulmonary Hypertension Affects the Mitochondrial Proteomic Landscape.
Autorzy :
James J; Department of Medicine, Division of Endocrinology, University of Arizona College of Medicine, Tucson, AZ 85721, USA.
Valuparampil Varghese M; Department of Medicine, Division of Endocrinology, University of Arizona College of Medicine, Tucson, AZ 85721, USA.
Vasilyev M; Department of Medicine, Division of Endocrinology, University of Arizona College of Medicine, Tucson, AZ 85721, USA.
Langlais PR; Department of Medicine, Division of Endocrinology, University of Arizona College of Medicine, Tucson, AZ 85721, USA.
Tofovic SP; Vascular Medicine Institute, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213; USA.
Rafikova O; Department of Medicine, Division of Endocrinology, University of Arizona College of Medicine, Tucson, AZ 85721, USA.
Rafikov R; Department of Medicine, Division of Endocrinology, University of Arizona College of Medicine, Tucson, AZ 85721, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Aug 08; Vol. 21 (16). Date of Electronic Publication: 2020 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
Proteomics*
Electron Transport Complex III/*antagonists & inhibitors
Hypertension, Pulmonary/*metabolism
Mitochondria/*metabolism
Animals ; Electron Transport Complex III/metabolism ; Fatty Acids/metabolism ; Female ; Models, Biological ; Proteome/metabolism ; Rats
Czasopismo naukowe
Tytuł :
Charge polarization imposed by the binding site facilitates enzymatic redox reactions of quinone.
Autorzy :
Pintscher S; Department of Molecular Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków 30387, Poland. Electronic address: .
Wójcik-Augustyn A; Department of Computational Biophysics and Bioinformatics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków 30387, Poland. Electronic address: .
Sarewicz M; Department of Molecular Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków 30387, Poland. Electronic address: .
Osyczka A; Department of Molecular Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków 30387, Poland. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Bioenergetics [Biochim Biophys Acta Bioenerg] 2020 Aug 01; Vol. 1861 (8), pp. 148216. Date of Electronic Publication: 2020 May 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Electron Transport Complex III/*metabolism
Quinones/*metabolism
Binding Sites ; Electron Transport Complex III/chemistry ; Electrons ; Models, Molecular ; Oxidation-Reduction ; Protein Conformation
Czasopismo naukowe
Tytuł :
Structural snapshots of the cellular folded protein translocation machinery Bcs1.
Autorzy :
Xia D; Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
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Źródło :
The FEBS journal [FEBS J] 2021 May; Vol. 288 (9), pp. 2870-2883. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Conformation*
ATPases Associated with Diverse Cellular Activities/*genetics
Mitochondria/*genetics
Mitochondrial Proteins/*genetics
Molecular Chaperones/*genetics
Saccharomyces cerevisiae Proteins/*genetics
ATPases Associated with Diverse Cellular Activities/ultrastructure ; Adenosine Triphosphatases/genetics ; Adenosine Triphosphate/genetics ; Animals ; Electron Transport Complex III/genetics ; Electron Transport Complex III/ultrastructure ; Humans ; Iron-Sulfur Proteins/genetics ; Iron-Sulfur Proteins/ultrastructure ; Mice ; Mitochondria/ultrastructure ; Mitochondrial Proteins/ultrastructure ; Molecular Chaperones/ultrastructure ; Protein Domains/genetics ; Protein Folding ; Protein Transport/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/ultrastructure
Czasopismo naukowe
Tytuł :
Timing of dimerization of the bc 1 complex during mitochondrial respiratory chain assembly.
Autorzy :
Stephan K; Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm, Sweden.
Ott M; Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm, Sweden. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Bioenergetics [Biochim Biophys Acta Bioenerg] 2020 Jun 01; Vol. 1861 (5-6), pp. 148177. Date of Electronic Publication: 2020 Feb 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Multimerization*
Electron Transport Complex III/*metabolism
Mitochondria/*metabolism
Electron Transport ; Electron Transport Complex III/chemistry ; Models, Molecular ; Protein Stability ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Time Factors
Czasopismo naukowe
Tytuł :
Assessment of Clofazimine and TB47 Combination Activity against Mycobacterium abscessus Using a Bioluminescent Approach.
Autorzy :
Liu Y; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Tan Y; State Key Laboratory of Respiratory Disease, Department of Clinical Laboratory, Guangzhou Chest Hospital, Guangzhou, China.
Islam MM; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.; University of Chinese Academy of Sciences, Beijing, China.
Cao Y; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Lu X; School of Pharmacy, Jinan University, Guangzhou, China.
Zeng S; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Hameed HMA; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhou P; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Cai X; State Key Laboratory of Respiratory Disease, Department of Clinical Laboratory, Guangzhou Chest Hospital, Guangzhou, China.
Wang S; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.; University of Chinese Academy of Sciences, Beijing, China.
Mugweru JN; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.; University of Chinese Academy of Sciences, Beijing, China.; Department of Biological Sciences, University of Embu, Embu, Kenya.
Zhang G; Guangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China.
Yin H; Chinese Academy of Sciences Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Jiangsu, China.
Liu J; State Key Laboratory of Respiratory Disease, Department of Clinical Laboratory, Guangzhou Chest Hospital, Guangzhou, China.
Nuermberger E; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Zhang T; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China .; University of Chinese Academy of Sciences, Beijing, China.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Feb 21; Vol. 64 (3). Date of Electronic Publication: 2020 Feb 21 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Clofazimine/*pharmacology
Electron Transport Complex III/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Mycobacterium Infections, Nontuberculous/*drug therapy
Mycobacterium abscessus/*drug effects
Amikacin/pharmacology ; Animals ; Bacterial Proteins/antagonists & inhibitors ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Clarithromycin/pharmacology ; Drug Combinations ; Drug Resistance, Multiple, Bacterial/drug effects ; Drug Resistance, Multiple, Bacterial/genetics ; Drug Synergism ; Electron Transport/drug effects ; Electron Transport Complex III/genetics ; Electron Transport Complex III/metabolism ; Female ; Genetic Engineering/methods ; Luminescence ; Mice ; Mice, Inbred BALB C ; Microbial Sensitivity Tests ; Mycobacterium Infections, Nontuberculous/enzymology ; Mycobacterium Infections, Nontuberculous/microbiology ; Mycobacterium Infections, Nontuberculous/pathology ; Mycobacterium abscessus/genetics ; Mycobacterium abscessus/metabolism ; Optical Imaging/methods ; Recombinases/genetics ; Recombinases/metabolism ; Roxithromycin/pharmacology
Czasopismo naukowe
Tytuł :
Mitochondrial DNA abnormalities provide mechanistic insight and predict reactive oxygen species-stimulating drug efficacy.
Autorzy :
Zaidieh T; School of Pharmacy and Biomedical Sciences, Institute of Biological and Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth, PO1 2DT, UK. .; Institute of Life Science, Swansea University Medical School, Swansea, SA2 8PP, UK. .
Smith JR; School of Pharmacy and Biomedical Sciences, Institute of Biological and Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth, PO1 2DT, UK.
Ball KE; School of Pharmacy and Biomedical Sciences, Institute of Biological and Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth, PO1 2DT, UK.
An Q; School of Pharmacy and Biomedical Sciences, Institute of Biological and Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth, PO1 2DT, UK. .
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Źródło :
BMC cancer [BMC Cancer] 2021 Apr 17; Vol. 21 (1), pp. 427. Date of Electronic Publication: 2021 Apr 17.
Typ publikacji :
Journal Article
MeSH Terms :
DNA, Mitochondrial*
Antineoplastic Agents/*pharmacology
Mitochondria/*drug effects
Mitochondria/*genetics
Mitochondria/*metabolism
Oxidation-Reduction/*drug effects
Reactive Oxygen Species/*metabolism
Antineoplastic Agents/chemistry ; Binding Sites ; DNA Copy Number Variations ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Electron Transport Complex I/chemistry ; Electron Transport Complex I/metabolism ; Electron Transport Complex III/chemistry ; Electron Transport Complex III/metabolism ; High-Throughput Nucleotide Sequencing ; Humans ; Models, Molecular ; Molecular Conformation ; Protein Binding ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Rcf2 revealed in cryo-EM structures of hypoxic isoforms of mature mitochondrial III-IV supercomplexes.
Autorzy :
Hartley AM; Institute of Structural and Molecular Biology, Birkbeck College, WC1E 7HX London, United Kingdom.
Meunier B; Institute for Integrative Biology of the Cell (I2BC), CNRS, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
Pinotsis N; Institute of Structural and Molecular Biology, Birkbeck College, WC1E 7HX London, United Kingdom.
Maréchal A; Institute of Structural and Molecular Biology, Birkbeck College, WC1E 7HX London, United Kingdom; .; Institute of Structural and Molecular Biology, University College London, WC1E 6BT London, United Kingdom.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Apr 28; Vol. 117 (17), pp. 9329-9337. Date of Electronic Publication: 2020 Apr 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Electron Transport Complex III/*metabolism
Electron Transport Complex IV/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Cryoelectron Microscopy/methods ; Electron Transport Complex III/chemistry ; Electron Transport Complex IV/chemistry ; Electron Transport Complex IV/physiology ; Hypoxia/metabolism ; Mitochondria/chemistry ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Protein Isoforms ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/physiology
Czasopismo naukowe
Tytuł :
Inhibition of the ox-LDL-Induced Pyroptosis by FGF21 of Human Umbilical Vein Endothelial Cells Through the TET2-UQCRC1-ROS Pathway.
Autorzy :
Chen JJ; Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, Hunan, China.
Tao J; Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, Hunan, China.
Zhang XL; Jiangsu College of Nursing, Huai'an, Jiangsu, China.
Xia LZ; Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, Hunan, China.
Zeng JF; Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, Hunan, China.
Zhang H; Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, Hunan, China.
Wei DH; Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, Hunan, China.
Lv YC; Clinical Anatomy & Reproductive Medicine Application Institute, University of South China, Hengyang, Hunan, China.
Li GH; Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, Hunan, China.
Wang Z; Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, Hunan, China.
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Źródło :
DNA and cell biology [DNA Cell Biol] 2020 Apr; Vol. 39 (4), pp. 661-670. Date of Electronic Publication: 2020 Feb 26.
Typ publikacji :
Journal Article
MeSH Terms :
Electron Transport Complex III/*metabolism
Fibroblast Growth Factors/*metabolism
Human Umbilical Vein Endothelial Cells/*metabolism
Lipoproteins, LDL/*metabolism
Pyroptosis/*physiology
Atherosclerosis/pathology ; Cell Survival ; Cells, Cultured ; DNA-Binding Proteins/metabolism ; Electron Transport Complex III/genetics ; Fibroblast Growth Factors/genetics ; Humans ; Membrane Potential, Mitochondrial/physiology ; Mitochondria/metabolism ; Oxidative Stress/physiology ; Proto-Oncogene Proteins/metabolism ; RNA Interference ; RNA, Small Interfering/genetics ; Reactive Oxygen Species/metabolism ; Signal Transduction
Czasopismo naukowe

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