TYROBP/DAP12 knockout in Huntington's disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration.
Authors:
Creus-Muncunill J; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA. Haure-Mirande JV; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA. Mattei D; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA. Bons J; Buck Institute for Research on Aging, Novato, CA, USA. Ramirez AV; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA. Hamilton BW; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA. Corwin C; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA. Chowdhury S; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA. Schilling B; Buck Institute for Research on Aging, Novato, CA, USA. EllerbyLM; Buck Institute for Research on Aging, Novato, CA, USA. Ehrlich ME; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, USA. .
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Source:
Journal of neuroinflammation [J Neuroinflammation] 2024 Mar 08; Vol. 21 (1), pp. 66. Date of Electronic Publication: 2024 Mar 08.
FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16 increase.
Authors:
Voisin J; Centre National de la Recherche Scientifique UMR 8256, Institut National de la Santé et de la Recherche Médicale ERL U1164, Assistance Publique-Hôpitaux de Paris, Brain-C Lab, Sorbonne Université, Paris, France. Farina F; Centre National de la Recherche Scientifique UMR 8256, Institut National de la Santé et de la Recherche Médicale ERL U1164, Assistance Publique-Hôpitaux de Paris, Brain-C Lab, Sorbonne Université, Paris, France. Naphade S; Buck Institute for Research on Aging, Novato, CA, USA. Fontaine M; Centre National de la Recherche Scientifique UMR 8256, Institut National de la Santé et de la Recherche Médicale ERL U1164, Assistance Publique-Hôpitaux de Paris, Brain-C Lab, Sorbonne Université, Paris, France. Tshilenge KT; Buck Institute for Research on Aging, Novato, CA, USA. Galicia Aguirre C; Buck Institute for Research on Aging, Novato, CA, USA. Lopez-Ramirez A; Buck Institute for Research on Aging, Novato, CA, USA. Dancourt J; Centre National de la Recherche Scientifique UMR 8256, Institut National de la Santé et de la Recherche Médicale ERL U1164, Assistance Publique-Hôpitaux de Paris, Brain-C Lab, Sorbonne Université, Paris, France. Ginisty A; Centre National de la Recherche Scientifique UMR 8256, Institut National de la Santé et de la Recherche Médicale ERL U1164, Assistance Publique-Hôpitaux de Paris, Brain-C Lab, Sorbonne Université, Paris, France. Sasidharan Nair S; Centre National de la Recherche Scientifique UMR 8256, Institut National de la Santé et de la Recherche Médicale ERL U1164, Assistance Publique-Hôpitaux de Paris, Brain-C Lab, Sorbonne Université, Paris, France. Lakshika Madushani K; Buck Institute for Research on Aging, Novato, CA, USA. Zhang N; Buck Institute for Research on Aging, Novato, CA, USA. Lejeune FX; Centre National de la Recherche Scientifique UMR 8256, Institut National de la Santé et de la Recherche Médicale ERL U1164, Assistance Publique-Hôpitaux de Paris, Brain-C Lab, Sorbonne Université, Paris, France. Verny M; Centre National de la Recherche Scientifique UMR 8256, Institut National de la Santé et de la Recherche Médicale ERL U1164, Assistance Publique-Hôpitaux de Paris, Brain-C Lab, Sorbonne Université, Paris, France. Campisi J; Buck Institute for Research on Aging, Novato, CA, USA.; Lawrence Berkeley National Laboratory, Berkeley, CA, USA. EllerbyLM; Buck Institute for Research on Aging, Novato, CA, USA. Neri C; Centre National de la Recherche Scientifique UMR 8256, Institut National de la Santé et de la Recherche Médicale ERL U1164, Assistance Publique-Hôpitaux de Paris, Brain-C Lab, Sorbonne Université, Paris, France.
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Source:
Aging cell [Aging Cell] 2020 Nov; Vol. 19 (11), pp. e13226. Date of Electronic Publication: 2020 Nov 06.
Publication Type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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