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Wyświetlanie 1-13 z 13
Tytuł :
Modeling Polyglutamine Expansion Diseases with Induced Pluripotent Stem Cells.
Autorzy :
Naphade S; Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA.
Tshilenge KT; Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA.
Ellerby LM; Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA. .
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Źródło :
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics [Neurotherapeutics] 2019 Oct; Vol. 16 (4), pp. 979-998.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Huntington Disease/*genetics
Huntington Disease/*metabolism
Induced Pluripotent Stem Cells/*metabolism
Peptides/*genetics
Peptides/*metabolism
Trinucleotide Repeat Expansion/*physiology
Animals ; Brain/metabolism ; Brain/pathology ; Humans ; Huntington Disease/pathology ; Induced Pluripotent Stem Cells/pathology ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Neurons/metabolism ; Neurons/pathology
Czasopismo naukowe
Tytuł :
Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction.
Autorzy :
Guyenet SJ; Department of Medicine (Medical Genetics) and.
Mookerjee SS; The Buck Institute for Research on Aging, Novato, CA 94945, USA.
Lin A; The Buck Institute for Research on Aging, Novato, CA 94945, USA.
Custer SK; Department of Medicine (Medical Genetics) and.
Chen SF; The Buck Institute for Research on Aging, Novato, CA 94945, USA.
Sopher BL; Department of Neurology, University of Washington, Seattle, WA, USA.
La Spada AR; Department of Medicine (Medical Genetics) and Department of Cellular and Molecular Medicine, Division of Biological Sciences, Institute for Genomic Medicine, and the Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA, USA, Department of Neurosciences, Division of Biological Sciences, Institute for Genomic Medicine, and the Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA, USA, Department of Pediatrics, Division of Biological Sciences, Institute for Genomic Medicine, and the Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA, USA and Rady Children's Hospital, San Diego, CA 92123, USA .
Ellerby LM; The Buck Institute for Research on Aging, Novato, CA 94945, USA, .
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Źródło :
Human molecular genetics [Hum Mol Genet] 2015 Jul 15; Vol. 24 (14), pp. 3908-17. Date of Electronic Publication: 2015 Apr 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Promoter Regions, Genetic*
Proteolysis*
Ataxin-7/*metabolism
Neurodegenerative Diseases/*genetics
Peptides/*metabolism
Retinal Degeneration/*genetics
Animals ; Aspartic Acid/metabolism ; Ataxin-7/genetics ; Caspase 7/genetics ; Caspase 7/metabolism ; Disease Models, Animal ; Genetic Therapy ; Humans ; Mice ; Mice, Transgenic ; Neurodegenerative Diseases/therapy ; Phenotype ; Purkinje Cells/metabolism ; Retinal Degeneration/therapy
Czasopismo naukowe
Tytuł :
Autophagy: polyQ toxic fragment turnover.
Autorzy :
Duncan C; Buck Institute for Age Research, Novato, CA, USA.
Papanikolaou T
Ellerby LM
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Źródło :
Autophagy [Autophagy] 2010 Feb; Vol. 6 (2), pp. 312-4. Date of Electronic Publication: 2010 Feb 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Peptide Fragments*/genetics
Peptide Fragments*/toxicity
Peptides*/genetics
Peptides*/toxicity
Autophagy/*physiology
Animals ; Ataxin-7 ; Caspase 7/genetics ; Caspase 7/metabolism ; Mice ; Mice, Transgenic ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Protein Processing, Post-Translational ; Spinocerebellar Ataxias/genetics ; Spinocerebellar Ataxias/metabolism ; Spinocerebellar Ataxias/pathology
Czasopismo naukowe
Tytuł :
Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk.
Autorzy :
Young JE; Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195-7110, USA.
Garden GA
Martinez RA
Tanaka F
Sandoval CM
Smith AC
Sopher BL
Lin A
Fischbeck KH
Ellerby LM
Morrison RS
Taylor JP
La Spada AR
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2009 Feb 18; Vol. 29 (7), pp. 1987-97.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*genetics
Apoptosis Regulatory Proteins/*metabolism
Neuropeptides/*metabolism
Peptides/*metabolism
Receptors, Androgen/*metabolism
Trinucleotide Repeat Expansion/*genetics
bcl-2-Associated X Protein/*metabolism
Animals ; Apoptosis Regulatory Proteins/genetics ; Cell Line ; Cells, Cultured ; Central Nervous System/metabolism ; Central Nervous System/pathology ; Central Nervous System/physiopathology ; JNK Mitogen-Activated Protein Kinases/metabolism ; Mice ; Mice, Transgenic ; Muscular Atrophy, Spinal/genetics ; Muscular Atrophy, Spinal/metabolism ; Muscular Atrophy, Spinal/physiopathology ; Neurons/metabolism ; Neurons/pathology ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Protein Folding ; Receptors, Androgen/chemistry ; Receptors, Androgen/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.
Autorzy :
Tanaka Y; Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, CMSC 8-121, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Igarashi S
Nakamura M
Gafni J
Torcassi C
Schilling G
Crippen D
Wood JD
Sawa A
Jenkins NA
Copeland NG
Borchelt DR
Ross CA
Ellerby LM
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Źródło :
Neurobiology of disease [Neurobiol Dis] 2006 Feb; Vol. 21 (2), pp. 381-91. Date of Electronic Publication: 2005 Sep 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Brain/*pathology
Huntington Disease/*physiopathology
Nerve Tissue Proteins/*metabolism
Nuclear Proteins/*metabolism
Peptides/*metabolism
Animals ; Blotting, Western ; Brain/physiopathology ; Cell Nucleus ; Huntingtin Protein ; Huntington Disease/genetics ; Huntington Disease/pathology ; Immunohistochemistry ; Intranuclear Inclusion Bodies/metabolism ; Intranuclear Inclusion Bodies/ultrastructure ; Mice ; Mice, Transgenic ; Mutation ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/genetics ; Phenotype ; Promoter Regions, Genetic
Czasopismo naukowe
Tytuł :
Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation.
Autorzy :
Iwata A; Department of Biological Sciences, BIO-X Program, Stanford University, Stanford, CA 94305-5430.
Christianson JC
Bucci M
Ellerby LM
Nukina N
Forno LS
Kopito RR
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2005 Sep 13; Vol. 102 (37), pp. 13135-40. Date of Electronic Publication: 2005 Sep 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Autophagy*
Cell Nucleus/*metabolism
Cytoplasm/*metabolism
Peptides/*metabolism
Ataxin-1 ; Ataxins ; Autophagy-Related Protein 12 ; Autophagy-Related Protein 5 ; Cell Line ; Humans ; Huntingtin Protein ; Huntington Disease ; Microtubule-Associated Proteins/metabolism ; Models, Biological ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Protein Transport ; Proteins/metabolism ; Small Ubiquitin-Related Modifier Proteins ; Spinocerebellar Ataxias ; Transfection
Czasopismo naukowe
Tytuł :
Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3.
Autorzy :
Berke SJ; Neuroscience Graduate Program and Department of Neurology, University of Iowa, Iowa City, Iowa 52242, USA. />Schmied FA
Brunt ER
Ellerby LM
Paulson HL
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Źródło :
Journal of neurochemistry [J Neurochem] 2004 May; Vol. 89 (4), pp. 908-18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Caspases/*metabolism
Machado-Joseph Disease/*metabolism
Nerve Tissue Proteins/*metabolism
Peptides/*genetics
Adult ; Amino Acid Sequence ; Animals ; Apoptosis/drug effects ; Apoptosis/physiology ; Ataxin-3 ; Binding Sites/genetics ; Binding Sites/physiology ; Brain/metabolism ; Brain Chemistry ; Caspase 1/metabolism ; Cells, Cultured ; Enzyme Inhibitors/pharmacology ; Female ; Humans ; Machado-Joseph Disease/genetics ; Macromolecular Substances ; Male ; Mice ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Nerve Tissue Proteins/genetics ; Nuclear Proteins ; Peptide Fragments/analysis ; Peptide Fragments/metabolism ; Rats ; Repressor Proteins ; Transcription Factors ; Trinucleotide Repeat Expansion/genetics
Czasopismo naukowe
Tytuł :
Kennedy's disease. Phosphorylation of the polyglutamine-expanded form of androgen receptor regulates its cleavage by caspase-3 and enhances cell death.
Autorzy :
LaFevre-Bernt MA; Buck Institute for Aging Research, Novato, California 94945, USA.
Ellerby LM
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2003 Sep 12; Vol. 278 (37), pp. 34918-24. Date of Electronic Publication: 2003 Jun 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Caspases/*metabolism
Muscular Atrophy, Spinal/*genetics
Muscular Atrophy, Spinal/*metabolism
Peptides/*metabolism
Receptors, Androgen/*genetics
Receptors, Androgen/*metabolism
Trinucleotide Repeat Expansion/*genetics
Alanine ; Amino Acid Substitution ; Base Sequence ; Caspase 3 ; Cell Death ; Cell Line ; DNA Primers ; Enzyme Activation ; Enzyme Inhibitors/pharmacology ; Humans ; Mitogen-Activated Protein Kinases/metabolism ; Muscular Atrophy, Spinal/pathology ; Mutagenesis, Site-Directed ; Phosphorylation ; Polymerase Chain Reaction ; Recombinant Proteins/metabolism ; Serine ; Transfection
Czasopismo naukowe
Tytuł :
Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity.
Autorzy :
Nucifora FC Jr; Division of Neurobiology, Department of Psychiatry, and The Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2196, USA.
Ellerby LM
Wellington CL
Wood JD
Herring WJ
Sawa A
Hayden MR
Dawson VL
Dawson TM
Ross CA
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2003 Apr 11; Vol. 278 (15), pp. 13047-55. Date of Electronic Publication: 2002 Dec 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Nerve Tissue Proteins/*genetics
Peptides/*genetics
Animals ; Atrophy ; Binding Sites, Antibody ; Brain/metabolism ; Brain/pathology ; Caspase 3 ; Caspases/metabolism ; Cell Nucleus/metabolism ; Dentate Gyrus/pathology ; Globus Pallidus/pathology ; Humans ; Huntington Disease/genetics ; Huntington Disease/pathology ; Mice ; Mice, Transgenic ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/metabolism ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/pathology ; Peptides/chemistry ; Recombinant Proteins/metabolism ; Repetitive Sequences, Amino Acid ; Sequence Deletion ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor.
Autorzy :
Lu DC; Program on Aging, The Burnham Institute, La Jolla, California 92037, USA.
Rabizadeh S
Chandra S
Shayya RF
Ellerby LM
Ye X
Salvesen GS
Koo EH
Bredesen DE
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Źródło :
Nature medicine [Nat Med] 2000 Apr; Vol. 6 (4), pp. 397-404.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Amyloid beta-Protein Precursor/*metabolism
Caspases/*metabolism
Peptides/*metabolism
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Protein Precursor/genetics ; Animals ; Apoptosis ; Brain/enzymology ; Brain/pathology ; Caspase 9 ; Caspases/genetics ; Cell Line, Transformed ; Enzyme Activation ; Humans ; Mice ; Peptide Fragments/metabolism ; Peptides/physiology ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Anti-cancer activity of targeted pro-apoptotic peptides.
Autorzy :
Ellerby HM; Program on Aging and Cancer and Program on Cell Adhesion, The Burnham Institute, 10901 North Torrey Pines Rd., La Jolla, California 92037, USA.
Arap W
Ellerby LM
Kain R
Andrusiak R
Rio GD
Krajewski S
Lombardo CR
Rao R
Ruoslahti E
Bredesen DE
Pasqualini R
Pokaż więcej
Źródło :
Nature medicine [Nat Med] 1999 Sep; Vol. 5 (9), pp. 1032-8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Breast Neoplasms/*blood supply
Peptides/*pharmacology
Protein Sorting Signals/*physiology
Amino Acid Sequence ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Breast Neoplasms/ultrastructure ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Design ; Endothelium, Vascular/cytology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/pathology ; Endothelium, Vascular/ultrastructure ; Female ; Humans ; Intracellular Membranes/drug effects ; Intracellular Membranes/pathology ; Intracellular Membranes/ultrastructure ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Mitochondria, Liver/drug effects ; Mitochondria, Liver/pathology ; Mitochondria, Liver/ultrastructure ; Neoplasm Transplantation ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/pathology ; Peptides/chemistry ; Peptides/metabolism ; Peptides/therapeutic use ; Protein Sorting Signals/genetics ; Rats ; Transplantation, Heterologous ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
Autorzy :
Wellington CL; Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
Ellerby LM
Hackam AS
Margolis RL
Trifiro MA
Singaraja R
McCutcheon K
Salvesen GS
Propp SS
Bromm M
Rowland KJ
Zhang T
Rasper D
Roy S
Thornberry N
Pinsky L
Kakizuka A
Ross CA
Nicholson DW
Bredesen DE
Hayden MR
Pokaż więcej
Źródło :
The Journal of biological chemistry [J Biol Chem] 1998 Apr 10; Vol. 273 (15), pp. 9158-67.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Caspases*
Peptides*
Trinucleotide Repeats*
Nerve Tissue Proteins/*metabolism
Neurodegenerative Diseases/*genetics
Nuclear Proteins/*metabolism
Serine Endopeptidases/*metabolism
Amino Acid Sequence ; Apoptosis ; Ataxin-3 ; Caspase 1 ; Caspase 3 ; Caspase 7 ; Caspase 8 ; Caspase 9 ; Cysteine Endopeptidases/metabolism ; Humans ; Huntingtin Protein ; Jurkat Cells ; Kinetics ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/chemistry ; Nuclear Proteins/genetics ; Osteosarcoma ; Receptors, Androgen/chemistry ; Receptors, Androgen/metabolism ; Repressor Proteins ; Substrate Specificity ; Tumor Cells, Cultured
Czasopismo naukowe
    Wyświetlanie 1-13 z 13

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