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Wyszukujesz frazę ""Endopeptidases"" wg kryterium: Temat


Tytuł:
Production and properties of adhesin-free gingipain proteinase RgpA.
Autorzy:
Mahmud ASM; Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Seers CA; Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Huq NL; Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Zhang L; Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Butler CA; Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Moore C; Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Cross KJ; Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, 3010, Australia.
Reynolds EC; Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, VIC, 3010, Australia. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jul 04; Vol. 13 (1), pp. 10780. Date of Electronic Publication: 2023 Jul 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cysteine Endopeptidases*/metabolism
Peptide Hydrolases*
Gingipain Cysteine Endopeptidases ; Adhesins, Bacterial/chemistry ; Catalytic Domain ; Porphyromonas gingivalis/metabolism ; Hemagglutinins/chemistry
Czasopismo naukowe
Tytuł:
SENP1 modulates chronic intermittent hypoxia-induced inflammation of microglia and neuronal injury by inhibiting TOM1 pathway.
Autorzy:
Wang H; Department of Respiratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. Electronic address: .
Wang X; Research Center of Respiratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Shen Y; Department of Respiratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Wang Y; Department of Respiratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Yang T; Department of Respiratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Sun J; Department of Respiratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Liu S; Department of Respiratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2023 Jun; Vol. 119, pp. 110230. Date of Electronic Publication: 2023 May 01.
Typ publikacji:
Journal Article
MeSH Terms:
Cysteine Endopeptidases*/genetics
Cysteine Endopeptidases*/metabolism
Microglia*/metabolism
Sleep Apnea, Obstructive*/metabolism
Animals ; Mice ; Endopeptidases ; Hypoxia/metabolism ; Inflammation/metabolism ; Mice, Inbred C57BL ; Neuroinflammatory Diseases ; Peptide Hydrolases/metabolism
Czasopismo naukowe
Tytuł:
USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunities.
Autorzy:
Gao ST; Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xin X; Key Laboratory of Liver and Kidney Diseases, Shanghai University of Traditional Chinese Medicine, Ministry of Education, Shanghai, China.
Wang ZY; Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hu YY; Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Key Laboratory of Liver and Kidney Diseases, Shanghai University of Traditional Chinese Medicine, Ministry of Education, Shanghai, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China. Electronic address: .
Feng Q; Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Key Laboratory of Liver and Kidney Diseases, Shanghai University of Traditional Chinese Medicine, Ministry of Education, Shanghai, China; Central Laboratory, ShuGuang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine, Shanghai, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China. Electronic address: .
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Źródło:
Molecular and cellular probes [Mol Cell Probes] 2024 Feb; Vol. 73, pp. 101944. Date of Electronic Publication: 2023 Dec 04.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Endopeptidases*/genetics
Endopeptidases*/metabolism
Neoplasms*/genetics
Humans ; Cell Proliferation ; Ubiquitin/genetics ; Ubiquitin/metabolism
Czasopismo naukowe
Tytuł:
Structural Basis for the SUMO2 Isoform Specificity of SENP7.
Autorzy:
Li Y; Institut de Biotecnologia i de Biomedicina (IBB) and Dept. de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
De Bolòs A; Institut de Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBABS), Barcelona 08036, Spain.
Amador V; Institut de Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBABS), Barcelona 08036, Spain.
Reverter D; Institut de Biotecnologia i de Biomedicina (IBB) and Dept. de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain. Electronic address: .
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Źródło:
Journal of molecular biology [J Mol Biol] 2022 Dec 30; Vol. 434 (24), pp. 167875. Date of Electronic Publication: 2022 Nov 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endopeptidases*/chemistry
Small Ubiquitin-Related Modifier Proteins*/chemistry
Sumoylation*
Humans ; Cysteine Endopeptidases/chemistry ; Protein Isoforms/chemistry ; Substrate Specificity
Czasopismo naukowe
Tytuł:
Purification of RgpA from external outer membrane vesicles of Porphyromonas gingivalis.
Autorzy:
Castillo DM; Universidad El Bosque, Vicerrectoría de investigaciones, Facultad de Odontología, Unidad de Investigación Básica Oral (UIBO), Av. Carrera 9 No 131A - 02, Bogotá D.C, Colombia. Electronic address: .
Castillo Y; Universidad El Bosque, Vicerrectoría de investigaciones, Facultad de Odontología, Unidad de Investigación Básica Oral (UIBO), Av. Carrera 9 No 131A - 02, Bogotá D.C, Colombia.
Delgadillo NA; Universidad El Bosque, Vicerrectoría de investigaciones, Facultad de Odontología, Unidad de Investigación Básica Oral (UIBO), Av. Carrera 9 No 131A - 02, Bogotá D.C, Colombia.
Neuta Y; Universidad El Bosque, Vicerrectoría de investigaciones, Facultad de Odontología, Unidad de Investigación Básica Oral (UIBO), Av. Carrera 9 No 131A - 02, Bogotá D.C, Colombia.
Lafaurie GI; Universidad El Bosque, Vicerrectoría de investigaciones, Facultad de Odontología, Unidad de Investigación Básica Oral (UIBO), Av. Carrera 9 No 131A - 02, Bogotá D.C, Colombia.
Romero-Sánchez C; Universidad El Bosque, School of Dentistry, Cellular and Molecular Immunilogy Group/INMUBO, Av. Carrera 9 No 131A - 02, Bogotá D.C, Colombia; Hospital Militar Central, Rheumatology and Immunology Department/Clinical Immunology Group/Universidad Militar Nueva Granada, School of Medicine, Transversal 3(a) # 49-00, Bogotá D.C, Colombia.
Castellanos JE; Universidad Nacional de Colombia, Facultad de Odontología, Carrera 30 No. 45-03, Edificio 210, Oficina 301, Bogotá D.C, Colombia.
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Źródło:
Anaerobe [Anaerobe] 2022 Oct; Vol. 77, pp. 102647. Date of Electronic Publication: 2022 Sep 16.
Typ publikacji:
Journal Article
MeSH Terms:
Porphyromonas gingivalis*/metabolism
Cysteine Endopeptidases*/metabolism
Rats ; Animals ; Gingipain Cysteine Endopeptidases ; Adhesins, Bacterial/metabolism ; Hemagglutinins/chemistry ; Hemagglutinins/metabolism
Czasopismo naukowe
Tytuł:
A non-peptide-based fluorescent probe capable of sensitively visualizing asparagine endopeptidase.
Autorzy:
Li K; State Key Laboratory of Fine Chemicals, Frontiers Science Centre for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China. .
Hou Y; State Key Laboratory of Fine Chemicals, Frontiers Science Centre for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China. .
Han J; State Key Laboratory of Fine Chemicals, Frontiers Science Centre for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China. .
Lv C; State Key Laboratory of Fine Chemicals, Frontiers Science Centre for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China. .
Liu W; State Key Laboratory of Fine Chemicals, Frontiers Science Centre for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China. .
Du J; State Key Laboratory of Fine Chemicals, Frontiers Science Centre for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China. .
Sun W; State Key Laboratory of Fine Chemicals, Frontiers Science Centre for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China. .
Fan J; State Key Laboratory of Fine Chemicals, Frontiers Science Centre for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China. .; Ningbo Institute of Dalian University of Technology, Ningbo 315016, China.
Peng X; State Key Laboratory of Fine Chemicals, Frontiers Science Centre for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China. .
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Źródło:
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Mar 12; Vol. 60 (22), pp. 3031-3034. Date of Electronic Publication: 2024 Mar 12.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorescent Dyes*
Cysteine Endopeptidases*
Czasopismo naukowe
Tytuł:
Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisomerase 1 cleavage complexes.
Autorzy:
Palani S; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA.
Machida Y; Department of Oncology, Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Alvey JR; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Mishra V; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Welter AL; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA.; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Cui G; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Bragantini B; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Botuyan MV; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Cong ATQ; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Mer G; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Schellenberg MJ; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA. .
Machida YJ; Department of Oncology, Division of Oncology Research, Mayo Clinic, Rochester, MN, USA. .; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. .; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA. .
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Źródło:
Nature communications [Nat Commun] 2024 Mar 07; Vol. 15 (1), pp. 2064. Date of Electronic Publication: 2024 Mar 07.
Typ publikacji:
Journal Article
MeSH Terms:
Serine Endopeptidases*/metabolism
Serine Proteases*
Dimerization ; Proteolysis ; DNA Replication ; Serine
Czasopismo naukowe
Tytuł:
FAP deficiency enhances thermogenesis and attenuates metabolic inflammation in diet-induced obesity.
Autorzy:
Wu Y; Department of Medical Microbiology and Immunology, Wannan Medical College, Wuhu, China.
Li Y; Department of Pharmacy, Wannan Medical College, Wuhu, China.
Sun M; Department of Pharmacy, Wannan Medical College, Wuhu, China.
Yu F; Department of Medical Microbiology and Immunology, Wannan Medical College, Wuhu, China.
Liu H; Department of Medical Microbiology and Immunology, Wannan Medical College, Wuhu, China.
Xu J; Department of Parasitology, Wannan Medical College, Wuhu, China.
Tang X; Department of Medical Microbiology and Immunology, Wannan Medical College, Wuhu, China.
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Źródło:
Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2024 Mar; Vol. 32 (3), pp. 528-539. Date of Electronic Publication: 2023 Dec 15.
Typ publikacji:
Journal Article
MeSH Terms:
Obesity*/metabolism
Insulin Resistance*
Membrane Proteins*
Endopeptidases*
Animals ; Mice ; Inflammation/metabolism ; Adipose Tissue, White/metabolism ; Diet, High-Fat/adverse effects ; Mice, Knockout ; Thermogenesis ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł:
Host genetics and the profile of COVID-19 in indigenous people from the Brazilian Amazon: A pilot study with variants of the ACE1, ACE2 and TMPRSS2 genes.
Autorzy:
Putira Sacuena ER; Laboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Brazil; Laboratory of Bioanthropological Studies in Health and Environment, Institute of Philosophy and Human Sciences, Federal University of Pará, Brazil.
Lima CNC; Virology Laboratory, Institute of Biological Sciences, Federal University of Pará, Brazil.
Abreu IN; Virology Laboratory, Institute of Biological Sciences, Federal University of Pará, Brazil.
da Silva LMC; Laboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Brazil.
Belleza LKG; Laboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Brazil.
Lemes RB; Laboratory of Human Population Genomics, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.
de Araújo GS; Laboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Brazil.
da Silva HP; Laboratory of Bioanthropological Studies in Health and Environment, Institute of Philosophy and Human Sciences, Federal University of Pará, Brazil.
Vallinoto ACR; Virology Laboratory, Institute of Biological Sciences, Federal University of Pará, Brazil.
Guerreiro JF; Laboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Brazil. Electronic address: .
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Źródło:
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2024 Mar; Vol. 118, pp. 105564. Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*/epidemiology
COVID-19*/genetics
Peptidyl-Dipeptidase A*/genetics
Serine Endopeptidases*/genetics
Female ; Humans ; Male ; Angiotensin-Converting Enzyme 2/genetics ; Brazil/epidemiology ; Pilot Projects ; SARS-CoV-2/physiology ; Indians, South American
Czasopismo naukowe
Tytuł:
Repurposing an endogenous degradation domain for antibody-mediated disposal of cell-surface proteins.
Autorzy:
Schmitt J; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Hills Road, CB2 0SP, Cambridge, UK.; Faculty of Medicine, Charité Berlin, 10117, Berlin, Germany.; Faculty of Medicine, University of Heidelberg, 69210, Heidelberg, Germany.
Poole E; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Hills Road, CB2 0SP, Cambridge, UK.; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.
Groves I; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Hills Road, CB2 0SP, Cambridge, UK.; Infection Biology, Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Owen DJ; Cambridge Institute for Medical Research, Keith Peters Building, Hills Road, Cambridge, CB2 0XY, UK. .
Graham SC; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK. .
Sinclair J; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Hills Road, CB2 0SP, Cambridge, UK. .
Kelly BT; Cambridge Institute for Medical Research, Keith Peters Building, Hills Road, Cambridge, CB2 0XY, UK. .
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Źródło:
EMBO reports [EMBO Rep] 2024 Mar; Vol. 25 (3), pp. 951-970. Date of Electronic Publication: 2024 Jan 29.
Typ publikacji:
Journal Article
MeSH Terms:
Proprotein Convertase 9*/metabolism
Serine Endopeptidases*
Humans ; Proprotein Convertases/metabolism ; Membrane Proteins ; Receptors, LDL/metabolism
Czasopismo naukowe
Tytuł:
Production of alkaline protease by Aspergillus niger in a new combinational paper waste culture medium.
Autorzy:
Nouri N; Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. Electronic address: .
Sadeghi L; Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. Electronic address: .
Marefat A; Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran. Electronic address: .
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Źródło:
Journal of bioscience and bioengineering [J Biosci Bioeng] 2024 Mar; Vol. 137 (3), pp. 173-178. Date of Electronic Publication: 2024 Jan 18.
Typ publikacji:
Journal Article
MeSH Terms:
Aspergillus niger*
Anti-Infective Agents*
Bacterial Proteins*
Endopeptidases*
Peptide Hydrolases ; Cellulose ; Carbon
Czasopismo naukowe
Tytuł:
The 1.7 Å crystal structure of the C5a peptidase from Streptococcus agalactiae (ScpB) reveals an active site competent for catalysis.
Autorzy:
Cullen R; Department of Biological Sciences, University of Limerick, Limerick, Ireland.
Teçza M; Department of Biological Sciences, University of Limerick, Limerick, Ireland.
Miclot T; Lycée Stanislas, Villers-de-Nancy, France.
Behan S; Department of Biological Sciences, University of Limerick, Limerick, Ireland.
Jain M; Department of Biological Sciences, University of Limerick, Limerick, Ireland.
Avink MK; School of Life Sciences, Engineering and Design, University of Applied Sciences, Saxion, The Netherlands.
Cooney JC; Department of Biological Sciences, University of Limerick, Limerick, Ireland.; Bernal Institute, University of Limerick, Limerick, Ireland.; SSPC, University of Limerick, Limerick, Ireland.
Kagawa TF; Department of Biological Sciences, University of Limerick, Limerick, Ireland.; SSPC, University of Limerick, Limerick, Ireland.
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Źródło:
Proteins [Proteins] 2024 Mar; Vol. 92 (3), pp. 427-431. Date of Electronic Publication: 2023 Nov 03.
Typ publikacji:
Journal Article
MeSH Terms:
Streptococcus agalactiae*/metabolism
Endopeptidases*/chemistry
Humans ; Catalytic Domain ; Adhesins, Bacterial/chemistry ; Adhesins, Bacterial/metabolism ; Catalysis ; Streptococcus pyogenes
Czasopismo naukowe
Tytuł:
Hepsin promotes breast tumor growth signaling via the TGFβ-EGFR axis.
Autorzy:
Belitškin D; Research Programs Unit/Translational Cancer Medicine Research Program and Medicum, Faculty of Medicine, University of Helsinki, Finland.
Munne P; Research Programs Unit/Translational Cancer Medicine Research Program and Medicum, Faculty of Medicine, University of Helsinki, Finland.
Pant SM; Research Programs Unit/Translational Cancer Medicine Research Program and Medicum, Faculty of Medicine, University of Helsinki, Finland.
Anttila JM; Research Programs Unit/Translational Cancer Medicine Research Program and Medicum, Faculty of Medicine, University of Helsinki, Finland.
Suleymanova I; Research Programs Unit/Translational Cancer Medicine Research Program and Medicum, Faculty of Medicine, University of Helsinki, Finland.
Belitškina K; Pathology Department, North Estonia Medical Centre, Tallinn, Estonia.
Kirchhofer D; Department of Early Discovery Biochemistry, Genentech, Inc., South San Francisco, CA, USA.
Janetka J; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.
Käsper T; Sixfold OÜ, Tartu, Estonia.
Jalil S; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Finland.
Pouwels J; Research Programs Unit/Translational Cancer Medicine Research Program and Medicum, Faculty of Medicine, University of Helsinki, Finland.
Tervonen TA; Research Programs Unit/Translational Cancer Medicine Research Program and Medicum, Faculty of Medicine, University of Helsinki, Finland.
Klefström J; Research Programs Unit/Translational Cancer Medicine Research Program and Medicum, Faculty of Medicine, University of Helsinki, Finland.; Foundation for the Finnish Cancer Institute, Helsinki & FICAN South, Helsinki University Hospital, Finland.
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Źródło:
Molecular oncology [Mol Oncol] 2024 Mar; Vol. 18 (3), pp. 547-561. Date of Electronic Publication: 2023 Nov 13.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/genetics
Epidermal Growth Factor*
Serine Endopeptidases*
Humans ; Male ; Cell Line, Tumor ; ErbB Receptors/genetics ; Receptors, Transforming Growth Factor beta ; Transforming Growth Factor beta
Czasopismo naukowe
Tytuł:
Mechanism of Mutation-Induced Effects on the Catalytic Function of TEV Protease: A Molecular Dynamics Study.
Autorzy:
Wang J; School of Biopharmacy, China Pharmaceutical University, Nanjing 211198, China.
Xu Y; School of Biopharmacy, China Pharmaceutical University, Nanjing 211198, China.
Wang X; School of Biopharmacy, China Pharmaceutical University, Nanjing 211198, China.
Li J; School of Biopharmacy, China Pharmaceutical University, Nanjing 211198, China.; Changzhou High-Tech Research Institute, Nanjing University, Changzhou 213164, China.
Hua Z; School of Biopharmacy, China Pharmaceutical University, Nanjing 211198, China.; Changzhou High-Tech Research Institute, Nanjing University, Changzhou 213164, China.; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing 210023, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 29; Vol. 29 (5). Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article
MeSH Terms:
Molecular Dynamics Simulation*
Endopeptidases*/metabolism
Biotechnology ; Mutation
Czasopismo naukowe
Tytuł:
Deaggregation of mutant Plasmodium yoelii de-ubiquitinase UBP1 alters MDR1 localization to confer multidrug resistance.
Autorzy:
Xu R; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Lin L; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Jiao Z; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Liang R; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Guo Y; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Zhang Y; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Shang X; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Wang Y; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Wang X; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Yao L; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Liu S; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Deng X; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Yuan J; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China. .
Su XZ; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20850, USA. .
Li J; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China. jianli_.
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Źródło:
Nature communications [Nat Commun] 2024 Feb 27; Vol. 15 (1), pp. 1774. Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article
MeSH Terms:
Plasmodium yoelii*/genetics
Malaria, Falciparum*/parasitology
Antimalarials*/therapeutic use
Endopeptidases*
Animals ; Mice ; Plasmodium falciparum/genetics ; Drug Resistance, Multiple/genetics ; Drug Resistance/genetics
Czasopismo naukowe
Tytuł:
Rational design of novel diaryl ether-linked benzimidazole derivatives as potent and selective BACE1 inhibitors.
Autorzy:
Quang De T; Department of Medicinal and Pharmaceutical Chemistry, University of Science and Technology, 217 Gajeong-ro Yuseong-gu, Daejeon, 305-333, South Korea.
Nguyen CQ; Department of Chemistry, College of Natural Sciences, Can Tho University, Can Tho, 94000, Viet Nam; Analytical Techniques Lab (1.16-ATL), CTU High-tech Building, Can Tho University, Can Tho, 94000, Viet Nam. Electronic address: .
Le Dang Q; Institute for Tropical Technology, Vietnam Academy of Science and Technology, Hanoi, 10072, Viet Nam; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, 10072, Viet Nam.
Nguyen Thi NY; Can Tho University of Technology, Can Tho, 94000, Viet Nam.
Trong Tuan N; Department of Chemistry, College of Natural Sciences, Can Tho University, Can Tho, 94000, Viet Nam.
Hoon Suh D; Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, P.O.Box 107, Yuseong-Gu, Daejeon, 305-600, South Korea.
Chu J; Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, P.O.Box 107, Yuseong-Gu, Daejeon, 305-600, South Korea.
Bepary S; Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, P.O.Box 107, Yuseong-Gu, Daejeon, 305-600, South Korea.
Lee GH; Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, P.O.Box 107, Yuseong-Gu, Daejeon, 305-600, South Korea.
Kang NS; Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, P.O.Box 107, Yuseong-Gu, Daejeon, 305-600, South Korea.
Cho H; Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, P.O.Box 107, Yuseong-Gu, Daejeon, 305-600, South Korea.
Park WK; Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, P.O.Box 107, Yuseong-Gu, Daejeon, 305-600, South Korea.
Lim HJ; Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, P.O.Box 107, Yuseong-Gu, Daejeon, 305-600, South Korea. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Feb 26; Vol. 698, pp. 149538. Date of Electronic Publication: 2024 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Amyloid Precursor Protein Secretases*/antagonists & inhibitors
Aspartic Acid Endopeptidases*/antagonists & inhibitors
Benzimidazoles*/pharmacology
Humans ; Alzheimer Disease ; Ethers ; Molecular Docking Simulation ; Drug Design
Czasopismo naukowe
Tytuł:
Correlation of Experimental and Calculated Inhibition Constants of Protease Inhibitor Complexes.
Autorzy:
Goettig P; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, Austria.; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Chen X; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Harris JM; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 19; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 19.
Typ publikacji:
Journal Article
MeSH Terms:
Serine Endopeptidases*
Helianthus*/metabolism
Trypsin Inhibitors/pharmacology ; Trypsin/metabolism ; Peptide Hydrolases ; Protease Inhibitors/pharmacology
Czasopismo naukowe
Tytuł:
Hepatic glycogenesis antagonizes lipogenesis by blocking S1P via UDPG.
Autorzy:
Chen J; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Zhou Y; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Liu Z; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Lu Y; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Jiang Y; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Cao K; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Zhou N; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Wang D; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Zhang C; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.; Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Zhou N; Department of Pathology, Sichuan Mianyang 404 Hospital, Sichuan 621000, China.
Shi K; Translational Medicine Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China.
Zhang L; Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
Zhou L; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Wang Z; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Zhang H; Department of Pathology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Tang K; Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Ma J; Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Lv J; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.
Huang B; Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.; Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Feb 16; Vol. 383 (6684), pp. eadi3332. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Lipogenesis*
Liver*/metabolism
Liver Glycogen*/metabolism
Non-alcoholic Fatty Liver Disease*/drug therapy
Non-alcoholic Fatty Liver Disease*/metabolism
Proprotein Convertases*/metabolism
Serine Endopeptidases*
Uridine Diphosphate Glucose*/administration & dosage
Uridine Diphosphate Glucose*/metabolism
Animals ; Humans ; Mice ; Carbon/metabolism ; Glucose/metabolism ; Hepatocytes/metabolism ; Sterol Regulatory Element Binding Protein 1/genetics ; Sterol Regulatory Element Binding Protein 1/metabolism ; Male ; Mice, Inbred C57BL ; HEK293 Cells
Czasopismo naukowe
Tytuł:
FAP Targeting of Photosensitizer-Loaded Polymersomes for Increased Light-Activated Cell Killing.
Autorzy:
Skowicki M; Department of Chemistry, University of Basel, BPR 1096, Mattenstrasse 22, 4058 Basel, Switzerland.; NCCR-Molecular Systems Engineering, BPR 1095, Mattenstrasse 24a, 4058 Basel, Switzerland.
Hürlimann D; Department of Chemistry, University of Basel, BPR 1096, Mattenstrasse 22, 4058 Basel, Switzerland.; NCCR-Molecular Systems Engineering, BPR 1095, Mattenstrasse 24a, 4058 Basel, Switzerland.
Tarvirdipour S; Department of Chemistry, University of Basel, BPR 1096, Mattenstrasse 22, 4058 Basel, Switzerland.
Kyropoulou M; Department of Chemistry, University of Basel, BPR 1096, Mattenstrasse 22, 4058 Basel, Switzerland.; NCCR-Molecular Systems Engineering, BPR 1095, Mattenstrasse 24a, 4058 Basel, Switzerland.
Schoenenberger CA; Department of Chemistry, University of Basel, BPR 1096, Mattenstrasse 22, 4058 Basel, Switzerland.; NCCR-Molecular Systems Engineering, BPR 1095, Mattenstrasse 24a, 4058 Basel, Switzerland.
Gerber-Lemaire S; Group for Functionalized Biomaterials, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Palivan CG; Department of Chemistry, University of Basel, BPR 1096, Mattenstrasse 22, 4058 Basel, Switzerland.; NCCR-Molecular Systems Engineering, BPR 1095, Mattenstrasse 24a, 4058 Basel, Switzerland.
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Źródło:
Biomacromolecules [Biomacromolecules] 2024 Feb 12; Vol. 25 (2), pp. 754-766. Date of Electronic Publication: 2024 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Photosensitizing Agents*/pharmacology
Polymers*/pharmacology
Membrane Proteins*
Endopeptidases*
Humans ; Rose Bengal/pharmacology ; Cell Death ; Cell Line, Tumor
Czasopismo naukowe
Tytuł:
An intramolecular cross-talk in D29 mycobacteriophage endolysin governs the lytic cycle and phage-host population dynamics.
Autorzy:
Nair G; Microbiology and Molecular Biology Laboratory, Department of Biological Sciences, Indian Institute of Science Education and Research (IISER), Bhopal 462066, Madhya Pradesh, India.
Jain V; Microbiology and Molecular Biology Laboratory, Department of Biological Sciences, Indian Institute of Science Education and Research (IISER), Bhopal 462066, Madhya Pradesh, India.
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Źródło:
Science advances [Sci Adv] 2024 Feb 09; Vol. 10 (6), pp. eadh9812. Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Mycobacteriophages*/metabolism
Bacteriophages*/metabolism
Endopeptidases*
Mycobacterium smegmatis/metabolism ; Peptidoglycan/metabolism
Czasopismo naukowe

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