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Wyszukujesz frazę ""Endothelial Cells"" wg kryterium: Temat


Tytuł:
Expression of anti and pro-inflammatory genes in human endothelial cells activated by 25-hydroxycholesterol: A comparison of rivaroxaban and dabigatran.
Autorzy:
Gorzelak-Pabiś P; The Laboratory of Tissue Immunopharmacology, Department of Internal Diseases and Clinical Pharmacology, Medical University of Lodz, Lodz, Poland.
Pawlos A; The Laboratory of Tissue Immunopharmacology, Department of Internal Diseases and Clinical Pharmacology, Medical University of Lodz, Lodz, Poland.
Broncel M; The Laboratory of Tissue Immunopharmacology, Department of Internal Diseases and Clinical Pharmacology, Medical University of Lodz, Lodz, Poland.
Wojdan K; The Laboratory of Tissue Immunopharmacology, Department of Internal Diseases and Clinical Pharmacology, Medical University of Lodz, Lodz, Poland.
Woźniak E; The Laboratory of Tissue Immunopharmacology, Department of Internal Diseases and Clinical Pharmacology, Medical University of Lodz, Lodz, Poland.
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Źródło:
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2022 Aug; Vol. 49 (8), pp. 805-812. Date of Electronic Publication: 2022 Jun 08.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Atherosclerosis*/drug therapy
Atherosclerosis*/genetics
Atherosclerosis*/immunology
Cytokines*/genetics
Cytokines*/immunology
Dabigatran*/pharmacology
Dabigatran*/therapeutic use
Human Umbilical Vein Endothelial Cells*/drug effects
Human Umbilical Vein Endothelial Cells*/immunology
Hydroxycholesterols*/administration & dosage
Hydroxycholesterols*/adverse effects
Hydroxycholesterols*/pharmacology
Rivaroxaban*/pharmacology
Rivaroxaban*/therapeutic use
Administration, Oral ; Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; Atrial Fibrillation/drug therapy ; Endothelial Cells/drug effects ; Endothelial Cells/immunology ; Humans ; Interleukin-18/genetics ; Interleukin-18/immunology ; Interleukin-23/genetics ; Interleukin-23/immunology ; Oxysterols/administration & dosage ; Oxysterols/adverse effects ; Oxysterols/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/immunology ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/immunology
Czasopismo naukowe
Tytuł:
RNA Sequencing Reveals Beneficial Effects of Atorvastatin on Endothelial Cells in Acute Kawasaki Disease.
Autorzy:
Shimizu C; Department of Pediatrics University of California, San Diego La Jolla CA.
Kim J; Department of Biomedical Informatics University of California, San Diego La Jolla CA.
He M; Department of Medicine University of California, San Diego La Jolla CA.
Tremoulet AH; Department of Pediatrics University of California, San Diego La Jolla CA.; Rady Children's Hospital San Diego CA.
Hoffman HM; Department of Pediatrics University of California, San Diego La Jolla CA.; Rady Children's Hospital San Diego CA.
Shyy JY; Department of Medicine University of California, San Diego La Jolla CA.
Burns JC; Department of Pediatrics University of California, San Diego La Jolla CA.; Rady Children's Hospital San Diego CA.
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Źródło:
Journal of the American Heart Association [J Am Heart Assoc] 2022 Jul 19; Vol. 11 (14), pp. e025408. Date of Electronic Publication: 2022 Jul 15.
Typ publikacji:
Journal Article
MeSH Terms:
Endothelial Cells*/metabolism
Mucocutaneous Lymph Node Syndrome*/drug therapy
Mucocutaneous Lymph Node Syndrome*/genetics
Mucocutaneous Lymph Node Syndrome*/metabolism
Atorvastatin/pharmacology ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Immunoglobulins, Intravenous ; Inflammation/metabolism ; Infliximab/metabolism ; Infliximab/pharmacology ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł:
Dabigatran: its protective effect against endothelial cell damage by oxysterol.
Autorzy:
Gorzelak-Pabiś P; Dept. of Internal Diseases and Clinical Pharmacology, The Laboratory of Tissue Immunopharmacology, Medical University of Lodz, Poland. Electronic address: .
Broncel M; Dept. of Internal Diseases and Clinical Pharmacology, The Laboratory of Tissue Immunopharmacology, Medical University of Lodz, Poland.
Pawlos A; Dept. of Internal Diseases and Clinical Pharmacology, The Laboratory of Tissue Immunopharmacology, Medical University of Lodz, Poland.
Wojdan K; Dept. of Internal Diseases and Clinical Pharmacology, The Laboratory of Tissue Immunopharmacology, Medical University of Lodz, Poland.
Gajewski A; Department of Immunology and Allergy, Medical University of Lodz, Lodz, Poland.
Chałubiński M; Department of Immunology and Allergy, Medical University of Lodz, Lodz, Poland.
Woźniak E; Dept. of Internal Diseases and Clinical Pharmacology, The Laboratory of Tissue Immunopharmacology, Medical University of Lodz, Poland.
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Źródło:
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Mar; Vol. 147, pp. 112679. Date of Electronic Publication: 2022 Feb 02.
Typ publikacji:
Journal Article
MeSH Terms:
Chemokines/*drug effects
Cytokines/*drug effects
Dabigatran/*pharmacology
Endothelial Cells/*drug effects
Oxysterols/*pharmacology
Dose-Response Relationship, Drug ; Human Umbilical Vein Endothelial Cells ; Humans ; Inflammation Mediators/metabolism ; RNA, Messenger
Czasopismo naukowe
Tytuł:
Protective effect of berberine against LPS-induced endothelial cell injury via the JNK signaling pathway and autophagic mechanisms.
Autorzy:
Guo J; Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Clinical Medicine, Zhejiang University City College, School of Medicine, Hangzhou, China.
Chen W; Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Bao B; Department of Clinical Medicine, Zhejiang University City College, School of Medicine, Hangzhou, China.
Zhang D; Department of Clinical Medicine, Zhejiang University City College, School of Medicine, Hangzhou, China.
Pan J; Department of Clinical Medicine, Zhejiang University City College, School of Medicine, Hangzhou, China.
Zhang M; Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Institue of Emergency Medicine, Zhejiang University, Hangzhou, China.
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Źródło:
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 1324-1337.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy*/drug effects
MAP Kinase Signaling System*/drug effects
Berberine/*pharmacology
Endothelial Cells/*enzymology
Endothelial Cells/*pathology
Lipopolysaccharides/*toxicity
Protective Agents/*pharmacology
Adenine/analogs & derivatives ; Adenine/pharmacology ; Anthracenes/pharmacology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Endothelial Cells/drug effects ; Endothelial Cells/ultrastructure ; Human Umbilical Vein Endothelial Cells ; Humans ; Sirolimus/pharmacology
Czasopismo naukowe
Tytuł:
Shear Stress Alterations Activate BMP4/pSMAD5 Signaling and Induce Endothelial Mesenchymal Transition in Varicose Veins.
Autorzy:
Chandran Latha K; Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695014, India.
Sreekumar A; Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695014, India.
Beena V; Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695014, India.
S S BR; College of Pharmaceutical Sciences, Medical College, Thiruvananthapuram 695011, India.
Lakkappa RB; Vascular Surgery, Kempegowda Institute of Medical Sciences, Bangalore 560070, India.
Kalyani R; Sri Jayadeva Institute for Cardiovascular Sciences & Research, Bangalore 560069, India.
Nair R; St. Thomas Institute of Research on Venous Diseases, Changanassery 686104, India.
Kalpana SR; Sri Jayadeva Institute for Cardiovascular Sciences & Research, Bangalore 560069, India.
Kartha CC; Department of Neurology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi 682041, India.
Surendran S; Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695014, India.
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Źródło:
Cells [Cells] 2021 Dec 17; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Signal Transduction*/drug effects
Stress, Mechanical*
Bone Morphogenetic Protein 4/*metabolism
Endothelial Cells/*pathology
Mesoderm/*pathology
Smad5 Protein/*metabolism
Varicose Veins/*metabolism
Varicose Veins/*pathology
Adult ; Aged ; Biomarkers/metabolism ; Endothelial Cells/drug effects ; Female ; Gene Expression Profiling ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Male ; Middle Aged ; Neointima/pathology ; Phosphorylation/drug effects ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; Rheology/drug effects ; Small Molecule Libraries/pharmacology ; Snail Family Transcription Factors/metabolism ; Transforming Growth Factor beta1/metabolism ; Up-Regulation/drug effects ; Young Adult
Czasopismo naukowe
Tytuł:
PSMA-positive membranes secreted from prostate cancer cells have potency to transform vascular endothelial cells into an angiogenic state.
Autorzy:
Watanabe R; Department of Urology, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan.; Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan.
Maekawa M; Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan.; Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Matsuyama, Ehime, Japan.
Kiyoi T; Division of Analytical Bio-medicine, Advanced Research Support Center, Ehime University, Ehime, Japan.
Kurata M; Department of Pathology, Ehime University Graduate School of Medicine and Proteo-Science Center, Ehime, Japan.
Miura N; Department of Urology, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan.
Kikugawa T; Department of Urology, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan.
Higashiyama S; Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan.; Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, Matsuyama, Ehime, Japan.; Department of Molecular and Cellular Biology, Osaka International Cancer Institute, Osaka, Japan.
Saika T; Department of Urology, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan.
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Źródło:
The Prostate [Prostate] 2021 Dec; Vol. 81 (16), pp. 1390-1401. Date of Electronic Publication: 2021 Sep 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antigens, Surface/*metabolism
Endothelial Cells/*pathology
Glutamate Carboxypeptidase II/*metabolism
Neovascularization, Pathologic/*metabolism
Prostatic Neoplasms, Castration-Resistant/*metabolism
Aged ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Culture Media, Conditioned ; Gene Expression Profiling/methods ; Human Umbilical Vein Endothelial Cells ; Humans ; Immunohistochemistry ; Male ; Neoplasm Grading ; Prostate ; Prostatic Neoplasms, Castration-Resistant/pathology ; Prostatic Neoplasms, Castration-Resistant/surgery ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
Activation of the Constitutive Androstane Receptor Inhibits Leukocyte Adhesiveness to Dysfunctional Endothelium.
Autorzy:
López-Riera M; Institute of Health Research-INCLIVA, 46010 Valencia, Spain.
Ortega R; Institute of Health Research-INCLIVA, 46010 Valencia, Spain.
Hueso L; Institute of Health Research-INCLIVA, 46010 Valencia, Spain.
Montesinos MC; Department of Pharmacology, University of Valencia, 46010 Valencia, Spain.; Center of Molecular Recognition and Technological Development (IDM), 46100 Burjassot, Spain.
Gomez-Cabrera MC; Institute of Health Research-INCLIVA, 46010 Valencia, Spain.; Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain.; Biomedical Network Research Centre on Frailty and Healthy Aging (CIBERFES), 28029 Madrid, Spain.
Sanz MJ; Institute of Health Research-INCLIVA, 46010 Valencia, Spain.; Department of Pharmacology, University of Valencia, 46010 Valencia, Spain.; Biomedical Network Research Centre in Diabetes and Associated Metabolic Diseases (CIBERDEM), 28029 Madrid, Spain.
Real JT; Institute of Health Research-INCLIVA, 46010 Valencia, Spain.; Endocrinology and Nutrition Service, University Clinic Hospital of Valencia, 46010 Valencia, Spain.; Biomedical Network Research Centre in Diabetes and Associated Metabolic Diseases (CIBERDEM), 28029 Madrid, Spain.
Piqueras L; Institute of Health Research-INCLIVA, 46010 Valencia, Spain.; Department of Pharmacology, University of Valencia, 46010 Valencia, Spain.; Biomedical Network Research Centre in Diabetes and Associated Metabolic Diseases (CIBERDEM), 28029 Madrid, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 27; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 27.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Adhesion*
Endothelial Cells*
Leukocytes/*drug effects
Receptors, Cytoplasmic and Nuclear/*metabolism
Animals ; Constitutive Androstane Receptor ; Gene Expression Regulation ; Human Umbilical Vein Endothelial Cells ; Humans ; Leukocytes/metabolism ; Leukocytes/physiology ; Male ; Mice ; NF-kappa B/metabolism ; Signal Transduction ; Tumor Necrosis Factor-alpha/metabolism ; Vascular Cell Adhesion Molecule-1/genetics
Czasopismo naukowe
Tytuł:
Butein and Frondoside-A Combination Exhibits Additive Anti-Cancer Effects on Tumor Cell Viability, Colony Growth, and Invasion and Synergism on Endothelial Cell Migration.
Autorzy:
Sulaiman S; Department of Pharmacology & Therapeutics, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab Emirates.
Arafat K; Department of Pharmacology & Therapeutics, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab Emirates.
Al-Azawi AM; Department of Pharmacology & Therapeutics, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab Emirates.
AlMarzooqi NA; Department of Pharmacology & Therapeutics, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab Emirates.
Lootah SNAH; Department of Pharmacology & Therapeutics, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab Emirates.
Attoub S; Department of Pharmacology & Therapeutics, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain 17666, United Arab Emirates.; Institut National de la Santé et de la Recherche Médicale (INSERM), 75013 Paris, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 31; Vol. 23 (1). Date of Electronic Publication: 2021 Dec 31.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Movement*/drug effects
Antineoplastic Agents/*pharmacology
Chalcones/*pharmacology
Endothelial Cells/*pathology
Glycosides/*pharmacology
Triterpenes/*pharmacology
Animals ; Caspase 3/metabolism ; Caspase 7/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Chick Embryo ; Drug Synergism ; Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Neoplasm Invasiveness ; Neovascularization, Pathologic/pathology ; Phosphorylation/drug effects ; Poly(ADP-ribose) Polymerases/metabolism ; STAT3 Transcription Factor/metabolism ; Tumor Stem Cell Assay ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Gambogic amide inhibits angiogenesis by suppressing VEGF/VEGFR2 in endothelial cells in a TrkA-independent manner.
Autorzy:
Sui T; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Qiu B; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Qu J; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Wang Y; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Ran K; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Han W; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Peng X; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.; Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, China.
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Źródło:
Pharmaceutical biology [Pharm Biol] 2021 Dec; Vol. 59 (1), pp. 1566-1575.
Typ publikacji:
Journal Article
MeSH Terms:
Angiogenesis Inhibitors/*pharmacology
Endothelial Cells/*drug effects
Xanthones/*pharmacology
Angiogenesis Inhibitors/administration & dosage ; Animals ; Apoptosis/drug effects ; Cell Line ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Chickens ; Chorioallantoic Membrane/blood supply ; Chorioallantoic Membrane/drug effects ; Dose-Response Relationship, Drug ; Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells/drug effects ; Humans ; Receptor, trkA/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; Xanthones/administration & dosage
Czasopismo naukowe
Tytuł:
PEDF is an endogenous inhibitor of VEGF-R2 angiogenesis signaling in endothelial cells.
Autorzy:
Zhang M; Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, 251 Fukang Road, Tianjin, 300384, China.
Tombran-Tink J; Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, 251 Fukang Road, Tianjin, 300384, China; Department of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA, 17033, USA. Electronic address: .
Yang S; Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, 251 Fukang Road, Tianjin, 300384, China.
Zhang X; Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, 251 Fukang Road, Tianjin, 300384, China. Electronic address: .
Li X; Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, 251 Fukang Road, Tianjin, 300384, China. Electronic address: .
Barnstable CJ; Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, 251 Fukang Road, Tianjin, 300384, China; Department of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA, 17033, USA. Electronic address: .
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Źródło:
Experimental eye research [Exp Eye Res] 2021 Dec; Vol. 213, pp. 108828. Date of Electronic Publication: 2021 Nov 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Angiogenesis Inhibitors/*physiology
Endothelial Cells/*drug effects
Eye Proteins/*physiology
Nerve Growth Factors/*physiology
Retinal Vessels/*cytology
Serpins/*physiology
Signal Transduction/*physiology
Vascular Endothelial Growth Factor Receptor-2/*antagonists & inhibitors
Animals ; Blood Vessels/drug effects ; Blotting, Western ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Endothelial Cells/metabolism ; Enzyme-Linked Immunosorbent Assay ; Human Umbilical Vein Endothelial Cells/drug effects ; Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Primates ; Real-Time Polymerase Chain Reaction ; Tyrosine/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł:
Differential effects of cyclooxygenase-2 (COX-2) inhibitors on endoplasmic reticulum (ER) stress in human coronary artery endothelial cells.
Autorzy:
Haas MJ; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida Jacksonville College of Medicine, Jacksonville, FL 32209, USA.. Electronic address: .
Warda F; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida Jacksonville College of Medicine, Jacksonville, FL 32209, USA.
Bikkina P; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida Jacksonville College of Medicine, Jacksonville, FL 32209, USA.
Landicho MA; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida Jacksonville College of Medicine, Jacksonville, FL 32209, USA.
Kapadia P; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida Jacksonville College of Medicine, Jacksonville, FL 32209, USA.
Parekh S; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida Jacksonville College of Medicine, Jacksonville, FL 32209, USA.
Mooradian AD; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida Jacksonville College of Medicine, Jacksonville, FL 32209, USA.
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Źródło:
Vascular pharmacology [Vascul Pharmacol] 2022 Feb; Vol. 142, pp. 106948. Date of Electronic Publication: 2021 Nov 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cyclooxygenase 2 Inhibitors*/pharmacology
Endoplasmic Reticulum Stress*
Endoribonucleases*/metabolism
Endothelial Cells/*drug effects
Coronary Vessels/cytology ; Cyclooxygenase 2/metabolism ; Endoplasmic Reticulum/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Protein Serine-Threonine Kinases ; Unfolded Protein Response
Czasopismo naukowe
Tytuł:
Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration.
Autorzy:
Swaminathan B; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, USA.
Youn SW; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, USA.
Naiche LA; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, USA.
Du J; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, USA.
Villa SR; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, USA.
Metz JB; Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA.
Feng H; Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA.
Zhang C; Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA.
Kopan R; Division of Developmental Biology, Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Sims PA; Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA.
Kitajewski JK; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, USA. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jan 31; Vol. 12 (1), pp. 1655. Date of Electronic Publication: 2022 Jan 31.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cell Movement*
Neovascularization, Physiologic*
Brain/*blood supply
Endothelial Cells/*enzymology
Receptors, Notch/*metabolism
rho GTP-Binding Proteins/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Cell Proliferation ; Gene Expression Regulation, Enzymologic ; HEK293 Cells ; Human Umbilical Vein Endothelial Cells/enzymology ; Humans ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptors, Notch/genetics ; Signal Transduction ; Time Factors ; Transcription, Genetic ; ras Proteins/genetics ; ras Proteins/metabolism ; rho GTP-Binding Proteins/genetics
Czasopismo naukowe
Tytuł:
Fluid Shear Stress Regulates the Landscape of microRNAs in Endothelial Cell-Derived Small Extracellular Vesicles and Modulates the Function of Endothelial Cells.
Autorzy:
Chung J; Exollence Biotechnology Co., Ltd., Seoul 07985, Korea.
Kim KH; Exollence Biotechnology Co., Ltd., Seoul 07985, Korea.
Yu N; Research Institute, National Cancer Center, Goyangsi 10408, Korea.
An SH; Exollence Biotechnology Co., Ltd., Seoul 07985, Korea.
Lee S; Department of Life Sciences, Ewha Womans University, Seoul 03760, Korea.
Kwon K; Exollence Biotechnology Co., Ltd., Seoul 07985, Korea.; Department of Internal Medicine, Cardiology Division, School of Medicine, Ewha Womans University, Seoul 07985, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 24; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Endothelial Cells/*physiology
Extracellular Vesicles/*genetics
Mechanotransduction, Cellular/*physiology
Animals ; Apoptosis/genetics ; Cell Movement/genetics ; Cells, Cultured ; Extracellular Vesicles/metabolism ; Gene Expression/genetics ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/genetics ; Signal Transduction/genetics ; Stress, Mechanical ; Transcriptome/genetics
Czasopismo naukowe
Tytuł:
Bio-Engineering of Pre-Vascularized Islet Organoids for the Treatment of Type 1 Diabetes.
Autorzy:
Wassmer CH; Laboratory of Tissue Engineering and Organ Regeneration, Department of Surgery, University of Geneva, Geneva, Switzerland.; Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.; Faculty Diabetes Center, University of Geneva Medical Center, University of Geneva, Geneva, Switzerland.
Lebreton F; Laboratory of Tissue Engineering and Organ Regeneration, Department of Surgery, University of Geneva, Geneva, Switzerland.; Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.; Faculty Diabetes Center, University of Geneva Medical Center, University of Geneva, Geneva, Switzerland.
Bellofatto K; Laboratory of Tissue Engineering and Organ Regeneration, Department of Surgery, University of Geneva, Geneva, Switzerland.; Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.; Faculty Diabetes Center, University of Geneva Medical Center, University of Geneva, Geneva, Switzerland.
Perez L; Laboratory of Tissue Engineering and Organ Regeneration, Department of Surgery, University of Geneva, Geneva, Switzerland.; Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.; Faculty Diabetes Center, University of Geneva Medical Center, University of Geneva, Geneva, Switzerland.
Cottet-Dumoulin D; Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.; Faculty Diabetes Center, University of Geneva Medical Center, University of Geneva, Geneva, Switzerland.
Andres A; Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Bosco D; Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.; Faculty Diabetes Center, University of Geneva Medical Center, University of Geneva, Geneva, Switzerland.
Berney T; Laboratory of Tissue Engineering and Organ Regeneration, Department of Surgery, University of Geneva, Geneva, Switzerland.; Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Othenin-Girard V; Department of Pediatrics, Gynecology and Obstetrics, Faculty of Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Martinez De Tejada B; Department of Pediatrics, Gynecology and Obstetrics, Faculty of Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Cohen M; Department of Pediatrics, Gynecology and Obstetrics, Faculty of Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Olgasi C; Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Follenzi A; Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Berishvili E; Laboratory of Tissue Engineering and Organ Regeneration, Department of Surgery, University of Geneva, Geneva, Switzerland.; Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.; Faculty Diabetes Center, University of Geneva Medical Center, University of Geneva, Geneva, Switzerland.; Institute of Medical and Public Health Research, Ilia State University, Tbilisi, Georgia.
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Źródło:
Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2022 Jan 21; Vol. 35, pp. 10214. Date of Electronic Publication: 2022 Jan 21 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 1*/surgery
Islets of Langerhans*/cytology
Tissue Engineering*
Epithelial Cells/*cytology
Human Umbilical Vein Endothelial Cells/*cytology
Animals ; Bioengineering ; Endothelial Cells ; Humans ; Insulin/metabolism ; Islets of Langerhans Transplantation ; Mice ; Organoids/physiology ; Rats
Czasopismo naukowe
Tytuł:
Thromboxane A 2 receptor activation via G α13 -RhoA/C-ROCK-LIMK2-dependent signal transduction inhibits angiogenic sprouting of human endothelial cells.
Autorzy:
Eckenstaler R; Martin-Luther-University Halle-Wittenberg, Department of Clinical Pharmacy and Pharmacotherapy, Halle (Saale), Germany.
Ripperger A; Martin-Luther-University Halle-Wittenberg, Department of Clinical Pharmacy and Pharmacotherapy, Halle (Saale), Germany.
Hauke M; Martin-Luther-University Halle-Wittenberg, Department of Clinical Pharmacy and Pharmacotherapy, Halle (Saale), Germany.
Braun H; Martin-Luther-University Halle-Wittenberg, Department of Clinical Pharmacy and Pharmacotherapy, Halle (Saale), Germany.
Ergün S; Institute of Anatomy and Cell Biology, Julius-Maximilians-University, Würzburg, Germany.
Schwedhelm E; Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Benndorf RA; Martin-Luther-University Halle-Wittenberg, Department of Clinical Pharmacy and Pharmacotherapy, Halle (Saale), Germany. Electronic address: .
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Źródło:
Biochemical pharmacology [Biochem Pharmacol] 2022 Jul; Vol. 201, pp. 115069. Date of Electronic Publication: 2022 May 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
GTP-Binding Protein alpha Subunits, G12-G13*/metabolism
Human Umbilical Vein Endothelial Cells*/cytology
Human Umbilical Vein Endothelial Cells*/metabolism
Lim Kinases*/metabolism
Receptors, Thromboxane A2, Prostaglandin H2*/metabolism
rhoA GTP-Binding Protein*/genetics
rhoA GTP-Binding Protein*/metabolism
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology ; Humans ; Neovascularization, Physiologic ; Signal Transduction ; Vascular Endothelial Growth Factor A/metabolism ; rho-Associated Kinases ; rhoC GTP-Binding Protein
Czasopismo naukowe
Tytuł:
BMP-4 impedes endothelial cell migration in neointimal hyperplasia via FoXO-3 specific modulation of reactive oxygen species.
Autorzy:
Li Q; The Biotherapy Center, Tumor Hospital of Harbin Medical University, 150 Haping Road Harbin, PR China.
Kou X; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, PR China.
Qin X; The Biotherapy Center, Tumor Hospital of Harbin Medical University, 150 Haping Road Harbin, PR China.
Li Z; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, PR China.
Li J; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, PR China.
Chen C; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, PR China. Electronic address: .
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Źródło:
Atherosclerosis [Atherosclerosis] 2022 Jun; Vol. 351, pp. 9-17. Date of Electronic Publication: 2022 May 13.
Typ publikacji:
Journal Article
MeSH Terms:
Bone Morphogenetic Protein 4*/antagonists & inhibitors
Bone Morphogenetic Protein 4*/biosynthesis
Bone Morphogenetic Protein 4*/blood
Human Umbilical Vein Endothelial Cells*/metabolism
Human Umbilical Vein Endothelial Cells*/pathology
Animals ; Carotid Artery Injuries/blood ; Carotid Artery Injuries/metabolism ; Carotid Artery Injuries/pathology ; Cell Movement ; Cells, Cultured ; Forkhead Box Protein O3/biosynthesis ; Forkhead Box Protein O3/blood ; Humans ; Hyperplasia ; Neointima/blood ; Neointima/metabolism ; Neointima/pathology ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/blood ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase-1/biosynthesis ; Superoxide Dismutase-1/blood
Czasopismo naukowe
Tytuł:
The ester derivatives obtained by C-ring modification of podophyllotoxin-induced apoptosis and inhibited proliferation in Hemangioma Endothelial Cells via downregulation of PI3K/Akt signaling pathway.
Autorzy:
Zhao Y; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Li D; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Han Y; Department of Pharmacy, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China.
Wang H; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Du R; College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Yan Z; Department of Pharmacy, The First Affiliated Hospital of Soochow University, Suzhou, China.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2022 Jun; Vol. 99 (6), pp. 828-838. Date of Electronic Publication: 2022 Apr 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endothelial Cells*/drug effects
Endothelial Cells*/metabolism
Endothelial Cells*/pathology
Hemangioma*/drug therapy
Hemangioma*/metabolism
Hemangioma*/pathology
Phosphatidylinositol 3-Kinases*/metabolism
Podophyllotoxin*/pharmacology
Proto-Oncogene Proteins c-akt*/metabolism
Apoptosis/drug effects ; Cell Proliferation/drug effects ; Child ; Child, Preschool ; Down-Regulation/drug effects ; Esters/metabolism ; Humans ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł:
Spectrum of Novel Anti-Central Nervous System Autoantibodies in the Cerebrospinal Fluid of 119 Patients With Schizophreniform and Affective Disorders.
Autorzy:
Endres D; Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
von Zedtwitz K; Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Matteit I; Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Bünger I; Department of Neurology and Experimental Neurology, Universitätsmedizin Berlin, Berlin, Germany; German Center for Neurodegenerative Diseases Berlin, Berlin, Germany.
Foverskov-Rasmussen H; Department of Neurology and Experimental Neurology, Universitätsmedizin Berlin, Berlin, Germany; German Center for Neurodegenerative Diseases Berlin, Berlin, Germany.
Runge K; Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Feige B; Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Schlump A; Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Maier S; Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Nickel K; Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Berger B; Clinic of Neurology and Neurophysiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Schiele MA; Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Cunningham JL; Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden.
Domschke K; Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Basics in Neuromodulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Prüss H; Department of Neurology and Experimental Neurology, Universitätsmedizin Berlin, Berlin, Germany; German Center for Neurodegenerative Diseases Berlin, Berlin, Germany. Electronic address: .
Tebartz van Elst L; Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address: .
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Źródło:
Biological psychiatry [Biol Psychiatry] 2022 Aug 15; Vol. 92 (4), pp. 261-274. Date of Electronic Publication: 2022 Feb 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autoantibodies*
Endothelial Cells*
Animals ; Brain ; Granulocyte-Macrophage Colony-Stimulating Factor ; Humans ; Immunoglobulin G ; Mice ; Mood Disorders
Czasopismo naukowe
Tytuł:
A Cytological Atlas of the Human Liver Proteome from PROTEOME 2.0, a Publicly Available Database.
Autorzy:
Lao Y; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
Li Y; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.; Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou 510632, China.
Wang W; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Ren L; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Qian X; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
He F; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Chen X; Institute of Liver Transplantation, The Third Medical Center, Chinese PLA General Hospital, Beijing 100039, China.
Jiang Y; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.; Anhui Medical University, Hefei 230031, China.
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Źródło:
Journal of proteome research [J Proteome Res] 2022 Aug 05; Vol. 21 (8), pp. 1916-1929. Date of Electronic Publication: 2022 Jul 12.
Typ publikacji:
Journal Article
MeSH Terms:
Endothelial Cells*/metabolism
Proteome*/genetics
Proteome*/metabolism
Hepatic Stellate Cells ; Hepatocytes/metabolism ; Humans ; Kupffer Cells
Czasopismo naukowe
Tytuł:
Isolation and culture of rat intestinal mucosal microvascular endothelial cells using immunomagnetic beads.
Autorzy:
Wu Y; Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Animal Science and Technology College, Beijing University of Agriculture, Bejing 102206, China.
Wang Z; Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Animal Science and Technology College, Beijing University of Agriculture, Bejing 102206, China.
Hu G; Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Animal Science and Technology College, Beijing University of Agriculture, Bejing 102206, China.
Zhang T; Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Animal Science and Technology College, Beijing University of Agriculture, Bejing 102206, China. Electronic address: .
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Źródło:
Journal of immunological methods [J Immunol Methods] 2022 Aug; Vol. 507, pp. 113296. Date of Electronic Publication: 2022 Jun 05.
Typ publikacji:
Journal Article
MeSH Terms:
Endothelial Cells*
Endothelium, Vascular*/metabolism
Animals ; Antigens, CD34/metabolism ; Cell Adhesion Molecules/metabolism ; Cells, Cultured ; Immunomagnetic Separation/methods ; Intestinal Mucosa ; Mice ; Rats
Czasopismo naukowe

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