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Tytuł :
Resveratrol attenuates cigarette smoke induced endothelial apoptosis by activating Notch1 signaling mediated autophagy.
Autorzy :
Zong DD; Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.; Research Unit of Respiratory Disease, Central South University, Changsha, 410011, Hunan, China.; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, 410011, Hunan, China.
Liu XM; Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.; Research Unit of Respiratory Disease, Central South University, Changsha, 410011, Hunan, China.; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, 410011, Hunan, China.
Li JH; Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.; Research Unit of Respiratory Disease, Central South University, Changsha, 410011, Hunan, China.; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, 410011, Hunan, China.
Ouyang RY; Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.; Research Unit of Respiratory Disease, Central South University, Changsha, 410011, Hunan, China.; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, 410011, Hunan, China.
Long YJ; Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.; Research Unit of Respiratory Disease, Central South University, Changsha, 410011, Hunan, China.; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, 410011, Hunan, China.
Chen P; Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. .; Research Unit of Respiratory Disease, Central South University, Changsha, 410011, Hunan, China. .; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, 410011, Hunan, China. .
Chen Y; Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. .; Research Unit of Respiratory Disease, Central South University, Changsha, 410011, Hunan, China. .; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, 410011, Hunan, China. .
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Źródło :
Respiratory research [Respir Res] 2021 Jan 19; Vol. 22 (1), pp. 22. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*physiology
Autophagy/*physiology
Human Umbilical Vein Endothelial Cells/*metabolism
Receptor, Notch1/*metabolism
Resveratrol/*pharmacology
Smoke/*adverse effects
Antioxidants/pharmacology ; Apoptosis/drug effects ; Autophagy/drug effects ; Cigarette Smoking/adverse effects ; Cigarette Smoking/metabolism ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells/drug effects ; Humans ; Signal Transduction/drug effects ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Increased circulating CD31+/CD42b-EMPs in Perthes disease and inhibit HUVECs angiogenesis via endothelial dysfunction.
Autorzy :
Li B; Department of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Huang Q; Department of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Lin C; Department of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Lu R; Department of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Wang T; Department of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Chen X; Department of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Liu Z; Department of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Liu Y; Department of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Wu J; Department of Pediatric Orthopaedics, GuangZhou Women and Children's Medical Center, GuangZhou, China.
Wu Y; Department of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Liao S; Department of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. Electronic address: .
Ding X; Department of Trauma Orthopedic and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 15; Vol. 265, pp. 118749. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article
MeSH Terms :
Cell-Derived Microparticles/*metabolism
Endothelial Cells/*pathology
Legg-Calve-Perthes Disease/*immunology
Apoptosis/physiology ; Biomarkers/metabolism ; Case-Control Studies ; Cell-Derived Microparticles/pathology ; Child ; Child, Preschool ; Endothelial Cells/immunology ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/pathology ; Extracellular Vesicles/immunology ; Extracellular Vesicles/pathology ; Female ; Flow Cytometry/methods ; Human Umbilical Vein Endothelial Cells ; Humans ; Legg-Calve-Perthes Disease/blood ; Legg-Calve-Perthes Disease/pathology ; Male ; Neovascularization, Pathologic/immunology ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/pathology ; Phenotype ; Vascular Diseases/metabolism ; Vascular Diseases/pathology
Czasopismo naukowe
Tytuł :
Regulation of IL (Interleukin)-33 Production in Endothelial Cells via Kinase Activation and Fas/CD95 Upregulation.
Autorzy :
Duez C; CNRS UMR 9017, Inserm U1019, CIIL-Center for Infection and Immunity of Lille (C.D., P.M., V.L., C.G.), CHU Lille, Institut Pasteur de Lille, University Lille, France.
Gross B; Inserm U1011-EGID (B.G.), CHU Lille, Institut Pasteur de Lille, University Lille, France.
Marquillies P; CNRS UMR 9017, Inserm U1019, CIIL-Center for Infection and Immunity of Lille (C.D., P.M., V.L., C.G.), CHU Lille, Institut Pasteur de Lille, University Lille, France.
Ledroit V; CNRS UMR 9017, Inserm U1019, CIIL-Center for Infection and Immunity of Lille (C.D., P.M., V.L., C.G.), CHU Lille, Institut Pasteur de Lille, University Lille, France.
Ryffel B; Laboratory of Molecular and Experimental Immunology and Neurogenetics, CNRS UMR 7355, University of Orleans, France (B.R.).
Glineur C; CNRS UMR 9017, Inserm U1019, CIIL-Center for Infection and Immunity of Lille (C.D., P.M., V.L., C.G.), CHU Lille, Institut Pasteur de Lille, University Lille, France.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Nov; Vol. 40 (11), pp. 2619-2631. Date of Electronic Publication: 2020 Sep 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Dermatophagoides/*pharmacology
Endothelial Cells/*drug effects
Interleukin-33/*pharmacology
Lung/*blood supply
Phosphatidylinositol 3-Kinase/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
fas Receptor/*metabolism
Animals ; Caspase 8/metabolism ; Cell Line ; Endothelial Cells/enzymology ; Endothelial Cells/immunology ; Enzyme Activation ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/enzymology ; Human Umbilical Vein Endothelial Cells/immunology ; Humans ; Interleukin-33/genetics ; Interleukin-33/metabolism ; Mice ; Up-Regulation ; Wnt Signaling Pathway ; fas Receptor/genetics
Czasopismo naukowe
Tytuł :
Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs.
Autorzy :
Liu Y; Interdisciplinary Faculty of Toxicology, College Station, TX, 77843, United States; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, 77843, USA.
Sakolish C; Interdisciplinary Faculty of Toxicology, College Station, TX, 77843, United States; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, 77843, USA.
Chen Z; Interdisciplinary Faculty of Toxicology, College Station, TX, 77843, United States; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, 77843, USA.
Phan DTT; Departments of Molecular Biology and Biochemistry, USA.
Bender RHF; Departments of Molecular Biology and Biochemistry, USA.
Hughes CCW; Departments of Molecular Biology and Biochemistry, USA; Biomedical Engineering, University of California, Irvine, Irvine, CA, 92697, USA.
Rusyn I; Interdisciplinary Faculty of Toxicology, College Station, TX, 77843, United States; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, 77843, USA. Electronic address: .
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Źródło :
Toxicology [Toxicology] 2020 Dec 01; Vol. 445, pp. 152601. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Lab-On-A-Chip Devices*
Antineoplastic Agents/*therapeutic use
Human Umbilical Vein Endothelial Cells/*drug effects
Microfluidic Analytical Techniques/*methods
Neoplasms/*pathology
Neovascularization, Pathologic/*pathology
Antineoplastic Agents/pharmacology ; Cell Culture Techniques ; Dose-Response Relationship, Drug ; Endothelial Cells/drug effects ; Endothelial Cells/pathology ; HCT116 Cells ; Human Umbilical Vein Endothelial Cells/physiology ; Humans ; Neoplasms/drug therapy ; Neovascularization, Pathologic/drug therapy ; Organ Culture Techniques ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells.
Autorzy :
Inada H; Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Udono M; Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.
Matsuda-Ito K; Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.
Horisawa K; Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.
Ohkawa Y; Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.
Miura S; Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.
Goya T; Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Yamamoto J; Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.
Nagasaki M; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.; Human Biosciences Unit for the Top Global Course, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto, 606-8507, Japan.
Ueno K; Genome Medical Science Project, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.
Saitou D; Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.
Suyama M; Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.
Maehara Y; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Kumamaru W; Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University, Fukuoka, 812-8582, Japan.
Ogawa Y; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Sekiya S; Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan.
Suzuki A; Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 21; Vol. 11 (1), pp. 5292. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Reprogramming Techniques/*methods
Endothelial Cells/*cytology
Hepatocytes/*cytology
Stem Cells/*cytology
Animals ; Bile Ducts/cytology ; Bile Ducts/physiology ; Cell Aggregation ; Cell Differentiation/genetics ; Cell Differentiation/physiology ; Cells, Cultured ; Cellular Reprogramming/genetics ; Cellular Reprogramming/physiology ; Endothelial Cells/physiology ; Female ; Hepatocyte Nuclear Factor 1-alpha/genetics ; Hepatocyte Nuclear Factor 1-alpha/physiology ; Hepatocyte Nuclear Factor 3-gamma/genetics ; Hepatocyte Nuclear Factor 3-gamma/physiology ; Hepatocyte Nuclear Factor 6/genetics ; Hepatocyte Nuclear Factor 6/physiology ; Hepatocytes/physiology ; Hepatocytes/transplantation ; Heterografts ; Human Umbilical Vein Endothelial Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, SCID ; Spheroids, Cellular/cytology ; Spheroids, Cellular/physiology ; Stem Cells/physiology
Czasopismo naukowe
Tytuł :
The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models.
Autorzy :
Klems A; Department of Cell and Developmental Biology, Institute of Zoology (ZOO), Karlsruhe Institute of Technology (KIT), Fritz Haber Weg 4, 76131, Karlsruhe, Germany.
van Rijssel J; Molecular Cell Biology lab, Department Molecular and Cellular Hemostasis, Sanquin Research and Landsteiner Laboratory, Academic Medical Center at the University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands.
Ramms AS; Department of Cell and Developmental Biology, Institute of Zoology (ZOO), Karlsruhe Institute of Technology (KIT), Fritz Haber Weg 4, 76131, Karlsruhe, Germany.; Institute for Biological and Chemical Systems-Biological Information Processing, Karlsruhe Institute of Technology (KIT), PO Box 3640, 76021, Karlsruhe, Germany.
Wild R; Department of Cell and Developmental Biology, Institute of Zoology (ZOO), Karlsruhe Institute of Technology (KIT), Fritz Haber Weg 4, 76131, Karlsruhe, Germany.
Hammer J; Department of Cell and Developmental Biology, Institute of Zoology (ZOO), Karlsruhe Institute of Technology (KIT), Fritz Haber Weg 4, 76131, Karlsruhe, Germany.
Merkel M; Department of Cell and Developmental Biology, Institute of Zoology (ZOO), Karlsruhe Institute of Technology (KIT), Fritz Haber Weg 4, 76131, Karlsruhe, Germany.
Derenbach L; Department of Cell and Developmental Biology, Institute of Zoology (ZOO), Karlsruhe Institute of Technology (KIT), Fritz Haber Weg 4, 76131, Karlsruhe, Germany.
Préau L; Department of Cell and Developmental Biology, Institute of Zoology (ZOO), Karlsruhe Institute of Technology (KIT), Fritz Haber Weg 4, 76131, Karlsruhe, Germany.
Hinkel R; Laboratory Animal Science Unit, Leibnitz-Institut für Primatenforschung, Deutsches Primatenzentrum GmbH, Kellnerweg 4, 37077 Göttingen, Germany and DZHK (German Center for Cardiovascular Research), partner site Göttingen, Göttingen, Germany.
Suarez-Martinez I; Institute of Cardiovascular Organogenesis and Regeneration WWU Münster, Münster, Germany & Faculty of Medicine, WWU Münster, Münster, Germany & Cells in Motion Cluster of Excellence, Münster, Münster, Germany.
Schulte-Merker S; Institute of Cardiovascular Organogenesis and Regeneration WWU Münster, Münster, Germany & Faculty of Medicine, WWU Münster, Münster, Germany & Cells in Motion Cluster of Excellence, Münster, Münster, Germany.
Vidal R; Max Delbrück Center for Molecular Medicine (MDC), Berlin Institute of Medical Systems Biology & Berlin Institute of Health, Robert Rössle Strasse 10, 13092, Berlin, Germany.
Sauer S; Max Delbrück Center for Molecular Medicine (MDC), Berlin Institute of Medical Systems Biology & Berlin Institute of Health, Robert Rössle Strasse 10, 13092, Berlin, Germany.
Kivelä R; Stem Cells and Metabolism Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, and Wihuri Research Institute, Helsinki, Finland.
Alitalo K; Translational Cancer Medicine Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, and Wihuri Research Institute, Helsinki, Finland.
Kupatt C; Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, TUM Munich, Germany, and DZHK, (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
van Buul JD; Molecular Cell Biology lab, Department Molecular and Cellular Hemostasis, Sanquin Research and Landsteiner Laboratory, Academic Medical Center at the University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands.; Leeuwenhoek Centre for Advanced Microscopy, section Molecular Cytology at Swammerdam Institute for Life Sciences at University of Amsterdam, Amsterdam, The Netherlands.
le Noble F; Department of Cell and Developmental Biology, Institute of Zoology (ZOO), Karlsruhe Institute of Technology (KIT), Fritz Haber Weg 4, 76131, Karlsruhe, Germany. .; Institute for Biological and Chemical Systems-Biological Information Processing, Karlsruhe Institute of Technology (KIT), PO Box 3640, 76021, Karlsruhe, Germany. .; Institute of Experimental Cardiology, University of Heidelberg, Heidelberg Germany and DZHK (German Center for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 21; Vol. 11 (1), pp. 5319. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelial Cells/*cytology
Endothelial Cells/*physiology
Guanine Nucleotide Exchange Factors/*physiology
Vascular Endothelial Growth Factor A/*physiology
Vascular Remodeling/*physiology
Animals ; Animals, Genetically Modified ; Cell Size ; Cells, Cultured ; Guanine Nucleotide Exchange Factors/genetics ; Human Umbilical Vein Endothelial Cells ; Humans ; Models, Cardiovascular ; Placenta Growth Factor/genetics ; Placenta Growth Factor/physiology ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/physiology ; Signal Transduction ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor Receptor-1/genetics ; Vascular Endothelial Growth Factor Receptor-1/physiology ; Vascular Remodeling/genetics ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish/physiology ; Zebrafish Proteins/genetics ; Zebrafish Proteins/physiology ; rac1 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/physiology
Czasopismo naukowe
Tytuł :
hnRNPA2B1 inhibits the exosomal export of miR-503 in endothelial cells.
Autorzy :
Pérez-Boza J; Molecular Angiogenesis Laboratory, GIGA Research, ULiege, B34, Avenue de l'Hôpital, 1, 4000, Liège, Belgium.; Exosome Research Group and Medical Oncology, VUmc Cancer Center Amsterdam, 1118 De Boelelaan, 1182 DB, Amsterdam, The Netherlands.
Boeckx A; Molecular Angiogenesis Laboratory, GIGA Research, ULiege, B34, Avenue de l'Hôpital, 1, 4000, Liège, Belgium.
Lion M; Molecular Angiogenesis Laboratory, GIGA Research, ULiege, B34, Avenue de l'Hôpital, 1, 4000, Liège, Belgium.
Dequiedt F; Laboratoire de Signalisation et Interactions des Protéines, GIGA-Research, ULiege, B34, Avenue de l'Hôpital, 1, 4000, Liège, Belgium.
Struman I; Molecular Angiogenesis Laboratory, GIGA Research, ULiege, B34, Avenue de l'Hôpital, 1, 4000, Liège, Belgium. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2020 Nov; Vol. 77 (21), pp. 4413-4428. Date of Electronic Publication: 2020 Jan 02.
Typ publikacji :
Journal Article
MeSH Terms :
Endothelial Cells/*metabolism
Exosomes/*metabolism
Heterogeneous-Nuclear Ribonucleoprotein Group A-B/*metabolism
MicroRNAs/*metabolism
Annexin A2/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; RNA Transport
Czasopismo naukowe
Tytuł :
Stress-induced RNA-chromatin interactions promote endothelial dysfunction.
Autorzy :
Calandrelli R; Department of Bioengineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA.
Xu L; Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.; Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, 1500 Duarte Rd., Duarte, CA, 91010, USA.
Luo Y; Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, 1500 Duarte Rd., Duarte, CA, 91010, USA.
Wu W; Department of Bioengineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA.
Fan X; Department of Bioengineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA.
Nguyen T; Department of Bioengineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA.
Chen CJ; Department of Bioengineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA.
Sriram K; Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, 1500 Duarte Rd., Duarte, CA, 91010, USA.; Irell and Manella Graduate School of Biological Sciences, City of Hope, 1500 Duarte Rd., Duarte, CA, 91010, USA.
Tang X; Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, 1500 Duarte Rd., Duarte, CA, 91010, USA.
Burns AB; Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, 1500 Duarte Rd., Duarte, CA, 91010, USA.
Natarajan R; Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, 1500 Duarte Rd., Duarte, CA, 91010, USA.; Irell and Manella Graduate School of Biological Sciences, City of Hope, 1500 Duarte Rd., Duarte, CA, 91010, USA.
Chen ZB; Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, 1500 Duarte Rd., Duarte, CA, 91010, USA. .; Irell and Manella Graduate School of Biological Sciences, City of Hope, 1500 Duarte Rd., Duarte, CA, 91010, USA. .
Zhong S; Department of Bioengineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 15; Vol. 11 (1), pp. 5211. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin/*physiology
Endothelial Cells/*metabolism
RNA/*metabolism
Stress, Physiological/*physiology
DNA/metabolism ; Diabetes Mellitus/genetics ; Diabetes Mellitus/metabolism ; Epigenomics ; Gene Expression/drug effects ; Gene Regulatory Networks ; Glucose/metabolism ; Glucose/pharmacology ; Human Umbilical Vein Endothelial Cells ; Humans ; Plasminogen Activator Inhibitor 1/genetics ; Plasminogen Activator Inhibitor 1/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Necrosis Factor-alpha/pharmacology
Czasopismo naukowe
Tytuł :
Association of the 1q25 Diabetes-Specific Coronary Heart Disease Locus With Alterations of the γ-Glutamyl Cycle and Increased Methylglyoxal Levels in Endothelial Cells.
Autorzy :
Pipino C; Research Division, Joslin Diabetes Center, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Department of Medical, Oral and Biotechnological Sciences, Center for Advanced Studies and Technology - CAST (ex CeSI-MeT), University G. d'Annunzio of Chieti-Pescara, Chieti, Italy.
Shah H; Research Division, Joslin Diabetes Center, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.
Prudente S; Research Unit of Metabolic and Cardiovascular Diseases, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Di Pietro N; Department of Medical, Oral and Biotechnological Sciences, Center for Advanced Studies and Technology - CAST (ex CeSI-MeT), University G. d'Annunzio of Chieti-Pescara, Chieti, Italy.
Zeng L; Division of Nephrology, Department of Medicine, University of Michigan, Ann Arbor, MI.
Park K; Research Division, Joslin Diabetes Center, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.
Trischitta V; Research Unit of Diabetes and Endocrine Diseases, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.; Department of Experimental Medicine, Sapienza University, Rome, Italy.
Pennathur S; Division of Nephrology, Department of Medicine, University of Michigan, Ann Arbor, MI.
Pandolfi A; Department of Medical, Oral and Biotechnological Sciences, Center for Advanced Studies and Technology - CAST (ex CeSI-MeT), University G. d'Annunzio of Chieti-Pescara, Chieti, Italy.
Doria A; Research Division, Joslin Diabetes Center, Boston, MA .; Department of Medicine, Harvard Medical School, Boston, MA.
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Źródło :
Diabetes [Diabetes] 2020 Oct; Vol. 69 (10), pp. 2206-2216. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronary Disease/*metabolism
Endothelial Cells/*metabolism
Chromosomes, Human, Pair 1/metabolism ; Coronary Disease/genetics ; Dipeptides ; Endophthalmitis/metabolism ; Glutamate-Ammonia Ligase/metabolism ; Glutamates/metabolism ; Glutamine/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Pyruvaldehyde/metabolism ; RNA, Small Interfering/metabolism
Czasopismo naukowe
Tytuł :
E2F1/SNHG7/miR-186-5p/MMP2 axis modulates the proliferation and migration of vascular endothelial cell in atherosclerosis.
Autorzy :
Zhang S; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China.
Zhu X; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China.
Li G; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Sep 15; Vol. 257, pp. 118013. Date of Electronic Publication: 2020 Jun 27.
Typ publikacji :
Journal Article
MeSH Terms :
Atherosclerosis/*metabolism
Endothelial Cells/*metabolism
RNA, Long Noncoding/*metabolism
3' Untranslated Regions ; Apoptosis/genetics ; Atherosclerosis/physiopathology ; Cell Movement/genetics ; Cell Proliferation/genetics ; Disease Progression ; E2F1 Transcription Factor/metabolism ; Endothelial Cells/physiology ; Gene Knockdown Techniques ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Lipoproteins, LDL ; Matrix Metalloproteinase 2/genetics ; Matrix Metalloproteinase 2/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/physiology
Czasopismo naukowe
Tytuł :
Low-Level Nanog Expression in the Regulation of Quiescent Endothelium.
Autorzy :
Baruah J; From the Department of Psychiatry, Harvard Medical School, Boston, MA (J.B.).; Angiogenesis and Brain Development Laboratory, Division of Basic Neuroscience, McLean Hospital, Belmont, MA (J.B.).
Chaudhuri S; Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
Mastej V; Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
Axen C; Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
Hitzman R; Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
Ribeiro IMB; Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
Wary KK; Department of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Sep; Vol. 40 (9), pp. 2244-2264. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*/drug effects
Cellular Senescence*/drug effects
Coronary Vessels/*metabolism
Endothelial Cells/*metabolism
Endothelium, Vascular/*metabolism
Nanog Homeobox Protein/*metabolism
Animals ; Apoptosis ; Cells, Cultured ; Coronary Vessels/drug effects ; Coronary Vessels/pathology ; Endothelial Cells/drug effects ; Endothelial Cells/pathology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/pathology ; Female ; Fibrosis ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Nanog Homeobox Protein/deficiency ; Nanog Homeobox Protein/genetics ; Neovascularization, Physiologic ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/metabolism ; Telomerase/genetics ; Telomerase/metabolism ; Transcriptional Activation ; Wnt Signaling Pathway ; Wnt3A Protein/pharmacology
Czasopismo naukowe
Tytuł :
Glucose-induced, duration-dependent genome-wide DNA methylation changes in human endothelial cells.
Autorzy :
Aref-Eshghi E; Department of Pathology and Laboratory Medicine, London Health Sciences Centre, London, Ontario, Canada.
Biswas S; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.
Chen C; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.
Sadikovic B; Department of Pathology and Laboratory Medicine, London Health Sciences Centre, London, Ontario, Canada.; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.
Chakrabarti S; Department of Pathology and Laboratory Medicine, London Health Sciences Centre, London, Ontario, Canada.; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2020 Aug 01; Vol. 319 (2), pp. C268-C276. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging/*genetics
CpG Islands/*genetics
DNA Methylation/*genetics
Endothelial Cells/*metabolism
Aging/pathology ; CpG Islands/drug effects ; DNA/genetics ; DNA Methylation/drug effects ; Endothelial Cells/drug effects ; Epigenesis, Genetic ; Gene Expression Regulation/drug effects ; Genes, Homeobox/genetics ; Genome, Human/genetics ; Glucose/pharmacology ; Human Umbilical Vein Endothelial Cells ; Humans ; Promoter Regions, Genetic/drug effects
Czasopismo naukowe
Tytuł :
Low Shear Stress Upregulates CX3CR1 Expression by Inducing VCAM-1 via the NF-κB Pathway in Vascular Endothelial Cells.
Autorzy :
Zhao Y; Department of Physiology, School of Medicine, Xinjiang Medical University, Urumqi, 830011, Xinjiang, PR China.
Ren P; Department of Physiology, School of Medicine, Xinjiang Medical University, Urumqi, 830011, Xinjiang, PR China.
Li Q; Department of Cardiovascular Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, PR China.
Umar SA; Department of Cardiovascular Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, PR China.
Yang T; Department of Cardiovascular Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, PR China.
Dong Y; Department of Cardiovascular Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, PR China.
Yu F; Department of Cardiovascular Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, PR China. .
Nie Y; Department of Cardiovascular Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, PR China. .; Key Laboratory of Cardiovascular and Metabolic Diseases, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, PR China. .
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Źródło :
Cell biochemistry and biophysics [Cell Biochem Biophys] 2020 Sep; Vol. 78 (3), pp. 383-389. Date of Electronic Publication: 2020 Jul 19.
Typ publikacji :
Journal Article
MeSH Terms :
Shear Strength*
CX3C Chemokine Receptor 1/*metabolism
Endothelial Cells/*metabolism
NF-kappa B p50 Subunit/*metabolism
Vascular Cell Adhesion Molecule-1/*biosynthesis
Cell Survival ; Cells, Cultured ; Gene Silencing ; Human Umbilical Vein Endothelial Cells ; Humans ; Inflammation ; Microscopy, Fluorescence ; Signal Transduction ; Stress, Mechanical ; Up-Regulation
Czasopismo naukowe
Tytuł :
Endothelial MAP2K1 mutations in arteriovenous malformation activate the RAS/MAPK pathway.
Autorzy :
Smits PJ; Department of Plastic & Oral Surgery, Boston Children's Hospital, Harvard Medical School, USA.
Konczyk DJ; Department of Plastic & Oral Surgery, Boston Children's Hospital, Harvard Medical School, USA.
Sudduth CL; Department of Plastic & Oral Surgery, Boston Children's Hospital, Harvard Medical School, USA.
Goss JA; Department of Plastic & Oral Surgery, Boston Children's Hospital, Harvard Medical School, USA.
Greene AK; Department of Plastic & Oral Surgery, Boston Children's Hospital, Harvard Medical School, USA. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Aug 20; Vol. 529 (2), pp. 450-454. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Arteriovenous Malformations/*genetics
Endothelial Cells/*metabolism
MAP Kinase Kinase 1/*genetics
Mitogen-Activated Protein Kinases/*metabolism
ras Proteins/*metabolism
Arteriovenous Malformations/metabolism ; Arteriovenous Malformations/pathology ; Cells, Cultured ; Endothelial Cells/pathology ; Enzyme Activation ; Human Umbilical Vein Endothelial Cells ; Humans ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Signaling System ; Point Mutation
Czasopismo naukowe
Tytuł :
Effects of different separation methods on the physical and functional properties of extracellular vesicles.
Autorzy :
Jeon H; Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon, South Korea.
Kang SK; Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon, South Korea.
Lee MS; Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon, South Korea.
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Źródło :
PloS one [PLoS One] 2020 Jul 07; Vol. 15 (7), pp. e0235793. Date of Electronic Publication: 2020 Jul 07 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Fractionation/*methods
Endothelial Cells/*chemistry
Extracellular Vesicles/*chemistry
Biomarkers/analysis ; Centrifugation/methods ; Chemical Precipitation ; DNA/analysis ; Endothelial Cells/virology ; Extracellular Vesicles/virology ; Herpesviridae Infections/virology ; Herpesvirus 8, Human/isolation & purification ; Human Umbilical Vein Endothelial Cells ; Humans ; Proteins/analysis ; RNA/analysis
Czasopismo naukowe
Tytuł :
Ginsenoside Rb1 reduces H2O2‑induced HUVEC dysfunction by stimulating the sirtuin‑1/AMP‑activated protein kinase pathway.
Autorzy :
Zheng Z; Department of Cardiology, The Third Affiliated Hospital of Sun Yat‑sen University, Sun Yat‑sen University, Guangzhou, Guangdong 510630, P.R. China.
Wang M; Department of Cardiology, The Third Affiliated Hospital of Sun Yat‑sen University, Sun Yat‑sen University, Guangzhou, Guangdong 510630, P.R. China.
Cheng C; Department of Nephrology, The Third Affiliated Hospital of Sun Yat‑sen University, Sun Yat‑sen University, Guangzhou, Guangdong 510630, P.R. China.
Liu D; Department of Cardiology, The Third Affiliated Hospital of Sun Yat‑sen University, Sun Yat‑sen University, Guangzhou, Guangdong 510630, P.R. China.
Wu L; Department of Cardiology, The Third Affiliated Hospital of Sun Yat‑sen University, Sun Yat‑sen University, Guangzhou, Guangdong 510630, P.R. China.
Zhu J; Department of Cardiology, The Third Affiliated Hospital of Sun Yat‑sen University, Sun Yat‑sen University, Guangzhou, Guangdong 510630, P.R. China.
Qian X; Department of Cardiology, The Third Affiliated Hospital of Sun Yat‑sen University, Sun Yat‑sen University, Guangzhou, Guangdong 510630, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2020 Jul; Vol. 22 (1), pp. 247-256. Date of Electronic Publication: 2020 Apr 28.
Typ publikacji :
Journal Article
MeSH Terms :
AMP-Activated Protein Kinases/*metabolism
Cellular Senescence/*drug effects
Endothelial Cells/*drug effects
Enzyme Activators/*pharmacology
Ginsenosides/*pharmacology
Hydrogen Peroxide/*metabolism
Endothelial Cells/cytology ; Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Signal Transduction/drug effects ; Sirtuin 1/metabolism
Czasopismo naukowe
Tytuł :
Transcriptomic analysis suggested the involvement of impaired lipid droplet biogenesis in graphene oxide-induced cytotoxicity in human umbilical vein endothelial cells.
Autorzy :
Luo Y; Key Laboratory of Environment-Friendly Chemistry and Application of Ministry of Education, Laboratory of Biochemistry, College of Chemistry, Xiangtan University, Xiangtan, 411105, China.
Wang X; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, 510632, China.
Cao Y; Key Laboratory of Environment-Friendly Chemistry and Application of Ministry of Education, Laboratory of Biochemistry, College of Chemistry, Xiangtan University, Xiangtan, 411105, China. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Jan 05; Vol. 333, pp. 109325. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Profiling*
Cytotoxins/*toxicity
Graphite/*toxicity
Human Umbilical Vein Endothelial Cells/*drug effects
Human Umbilical Vein Endothelial Cells/*metabolism
Lipid Droplets/*drug effects
Lipid Droplets/*metabolism
Coenzyme A Ligases/genetics ; Fatty Acid Synthase, Type I/genetics ; Human Umbilical Vein Endothelial Cells/cytology ; Humans ; Oxidative Stress/drug effects ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Curcumol inhibits KLF5-dependent angiogenesis by blocking the ROS/ERK signaling in liver sinusoidal endothelial cells.
Autorzy :
Gao L; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.
Yang X; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.
Li Y; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.
Wang Z; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.
Wang S; Shandong Co-innovation Center of TCM Formula, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Tan S; Department of Integrated TCM and Western Medicine, Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing, China.
Chen A; Department of Pathology, School of Medicine, Saint Louis University, St Louis, USA.
Cao P; Jiangsu Key Laboratory of Therapeutic Material of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Shao J; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China; Jiangsu Key Laboratory of Therapeutic Material of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Zhang Z; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China; Jiangsu Key Laboratory of Therapeutic Material of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Zhang F; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China; Jiangsu Key Laboratory of Therapeutic Material of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China. Electronic address: .
Zheng S; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China; Jiangsu Key Laboratory of Therapeutic Material of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118696. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article
MeSH Terms :
MAP Kinase Signaling System*/drug effects
Endothelial Cells/*pathology
Kruppel-Like Transcription Factors/*metabolism
Liver/*pathology
Neovascularization, Pathologic/*drug therapy
Reactive Oxygen Species/*metabolism
Sesquiterpenes/*therapeutic use
Animals ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/pathology ; Male ; Mice, Inbred ICR ; Mitochondria/drug effects ; Mitochondria/metabolism ; Models, Biological ; Neovascularization, Pathologic/metabolism ; Oxidative Stress/drug effects ; Rats, Sprague-Dawley ; Sesquiterpenes/pharmacology
Czasopismo naukowe
Tytuł :
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.
Autorzy :
Palikuqi B; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Nguyen DT; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Li G; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Schreiner R; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Ophthalmology, Margaret Dyson Vision Research Institute, Weill Cornell Medicine, New York, NY, USA.
Pellegata AF; Stem Cell and Regenerative Medicine Section, DBC Programme, Great Ormond Street Institute of Child Health, University College London, London, UK.
Liu Y; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Redmond D; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Geng F; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Lin Y; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Gómez-Salinero JM; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Yokoyama M; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Zumbo P; Applied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Zhang T; Genomics Resources Core Facility, Weill Cornell Medicine, New York, NY, USA.
Kunar B; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Witherspoon M; Sandra and Edward Meyer Cancer Center, Weill Cornell Graduate School of Medical Sciences, Departments of Biochemistry and Medicine, Weill Cornell Medicine, New York, NY, USA.
Han T; Sandra and Edward Meyer Cancer Center, Weill Cornell Graduate School of Medical Sciences, Departments of Biochemistry and Medicine, Weill Cornell Medicine, New York, NY, USA.
Tedeschi AM; Stem Cell and Regenerative Medicine Section, DBC Programme, Great Ormond Street Institute of Child Health, University College London, London, UK.
Scottoni F; Stem Cell and Regenerative Medicine Section, DBC Programme, Great Ormond Street Institute of Child Health, University College London, London, UK.
Lipkin SM; Sandra and Edward Meyer Cancer Center, Weill Cornell Graduate School of Medical Sciences, Departments of Biochemistry and Medicine, Weill Cornell Medicine, New York, NY, USA.
Dow L; Sandra and Edward Meyer Cancer Center, Weill Cornell Graduate School of Medical Sciences, Departments of Biochemistry and Medicine, Weill Cornell Medicine, New York, NY, USA.
Elemento O; Caryl and Israel Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Xiang JZ; Genomics Resources Core Facility, Weill Cornell Medicine, New York, NY, USA.
Shido K; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Spence JR; Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Zhou QJ; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Schwartz RE; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA.
De Coppi P; Stem Cell and Regenerative Medicine Section, DBC Programme, Great Ormond Street Institute of Child Health, University College London, London, UK.; Specialist Neonatal and Paediatric Surgery, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Rabbany SY; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Bioengineering Program, DeMatteis School of Engineering and Applied Science, Hofstra University, Hempstead, NY, USA.
Rafii S; Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA. .
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Źródło :
Nature [Nature] 2020 Sep; Vol. 585 (7825), pp. 426-432. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Carcinogenesis*
Hemodynamics*
Organogenesis*
Blood Vessels/*cytology
Endothelial Cells/*cytology
Neoplasms/*blood supply
Organoids/*blood supply
Blood Vessels/growth & development ; Cell Culture Techniques/instrumentation ; Cell Culture Techniques/methods ; Chromatin/metabolism ; Epigenesis, Genetic ; Epigenomics ; Human Umbilical Vein Endothelial Cells ; Humans ; In Vitro Techniques ; Islets of Langerhans/blood supply ; Models, Biological ; Organ Specificity ; RNA-Seq ; Single-Cell Analysis ; Transcription Factors ; Transcriptome
Czasopismo naukowe
Tytuł :
Vascular Remodeling in Moyamoya Angiopathy: From Peripheral Blood Mononuclear Cells to Endothelial Cells.
Autorzy :
Tinelli F; Laboratory of Cellular Neurobiology, Neurology IX Unit, UCV, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Nava S; Laboratory of Cellular Neurobiology, Neurology IX Unit, UCV, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Arioli F; Laboratory of Cellular Neurobiology, Neurology IX Unit, UCV, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Bedini G; Immunology and Cell Therapy Unit, Tettamanti Research Center, University of Milano-Bicocca, 20900 Monza, Italy.
Scelzo E; Neurology IX Unit, UCV, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Lisini D; Laboratory of Cellular Neurobiology, Neurology IX Unit, UCV, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Faragò G; Diagnostic Imaging & Interventional Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Gioppo A; Diagnostic Imaging & Interventional Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Ciceri EF; Diagnostic Imaging & Interventional Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Acerbi F; Neurosurgical II Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Ferroli P; Neurosurgical II Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Vetrano IG; Neurosurgical II Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Esposito S; Developmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Saletti V; Developmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Pantaleoni C; Developmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Zibordi F; Department of Pediatric Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Nardocci N; Department of Pediatric Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Zedde ML; Neurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.
Pezzini A; Department of Clinical and Experimental Sciences, Clinica Neurologica, Università degli Studi di Brescia, 25121 Brescia, Italy.
Di Lazzaro V; Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.
Capone F; Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.
Dell'Acqua ML; Stroke Unit, Neurology Clinic, Department of Biomedical Metabolic and Neural Sciences, Nuovo Ospedale Civile S Agostino Estense, University of Modena and Reggio Emilia, 41126 Modena, Italy.
Vajkoczy P; Department of Neurosurgery, Charite Universitätsmedizin, 10117 Berlin, Germany.
Tournier-Lasserve E; Department of Genetics, Lariboisière Hospital and INSERM U1141, Paris-Diderot University, 75010 Paris, France.
Parati EA; Neurology IX Unit, UCV, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Bersano A; Neurology IX Unit, UCV, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Gatti L; Laboratory of Cellular Neurobiology, Neurology IX Unit, UCV, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Aug 11; Vol. 21 (16). Date of Electronic Publication: 2020 Aug 11.
Typ publikacji :
Journal Article
MeSH Terms :
Vascular Remodeling*/genetics
Endothelial Cells/*pathology
Leukocytes, Mononuclear/*pathology
Moyamoya Disease/*physiopathology
Adult ; Biomarkers/blood ; Cell Count ; Child ; Cytokines/metabolism ; Female ; Gene Expression Regulation ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Male ; Moyamoya Disease/blood ; Moyamoya Disease/genetics ; Neovascularization, Physiologic ; Paracrine Communication ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe

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