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Wyszukujesz frazę ""Endothelial Protein C Receptor"" wg kryterium: Temat


Tytuł :
Endothelial Cell Protein C Receptor Deficiency Attenuates Streptococcus pneumoniae- induced Pleural Fibrosis.
Autorzy :
Keshava S; Department of Cellular and Molecular Biology.
Magisetty J; Department of Cellular and Molecular Biology.
Tucker TA; Department of Cellular and Molecular Biology.
Kujur W; Department of Pulmonary Immunology, The University of Texas Health Science Center at Tyler, Tyler, Texas; and.
Mulik S; Department of Pulmonary Immunology, The University of Texas Health Science Center at Tyler, Tyler, Texas; and.
Esmon CT; Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.
Idell S; Department of Cellular and Molecular Biology.
Rao LVM; Department of Cellular and Molecular Biology.
Pendurthi UR; Department of Cellular and Molecular Biology.
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Źródło :
American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2021 Apr; Vol. 64 (4), pp. 477-491.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelial Protein C Receptor/*deficiency
Lung/*metabolism
Pleura/*metabolism
Pleural Effusion/*metabolism
Pleurisy/*metabolism
Pneumonia, Pneumococcal/*metabolism
Streptococcus pneumoniae/*pathogenicity
Animals ; Bacterial Load ; Cells, Cultured ; Disease Models, Animal ; Endothelial Protein C Receptor/genetics ; Female ; Fibrosis ; Host-Pathogen Interactions ; Humans ; Lung/microbiology ; Lung/pathology ; Lung/physiopathology ; Macrophages/metabolism ; Macrophages/microbiology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Neutrophil Infiltration ; Neutrophils/metabolism ; Neutrophils/microbiology ; Pleura/microbiology ; Pleura/pathology ; Pleural Effusion/microbiology ; Pleural Effusion/pathology ; Pleural Effusion/physiopathology ; Pleurisy/microbiology ; Pleurisy/pathology ; Pleurisy/physiopathology ; Pneumonia, Pneumococcal/microbiology ; Pneumonia, Pneumococcal/pathology ; Pneumonia, Pneumococcal/physiopathology
Czasopismo naukowe
Tytuł :
Lipid presentation by the protein C receptor links coagulation with autoimmunity.
Autorzy :
Müller-Calleja N; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA.
Hollerbach A; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Royce J; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA.
Ritter S; Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Pedrosa D; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Madhusudhan T; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Teifel S; Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Meineck M; Department of Medicine I, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Häuser F; Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Canisius A; Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Nguyen TS; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Braun J; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Bruns K; Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Etzold A; Institute of Human Genetics, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; Senckenberg Zentrum für Humangenetik, 60314 Frankfurt, Germany.
Zechner U; Institute of Human Genetics, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.; Senckenberg Zentrum für Humangenetik, 60314 Frankfurt, Germany.
Strand S; Department of Medicine I, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Radsak M; Department of Medicine III, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Strand D; Department of Medicine I, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Gu JM; Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Weinmann-Menke J; Department of Medicine I, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany.
Esmon CT; Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Teyton L; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA.
Lackner KJ; Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany. .
Ruf W; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany. .; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Mar 12; Vol. 371 (6534).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigen Presentation*
Autoimmunity*
Blood Coagulation/*immunology
Endothelial Protein C Receptor/*immunology
Lupus Erythematosus, Systemic/*immunology
Lysophospholipids/*immunology
Monoglycerides/*immunology
Animals ; Antibodies, Antiphospholipid/biosynthesis ; Autoantibodies/biosynthesis ; Disease Models, Animal ; Embryo Loss/immunology ; Endosomes/immunology ; Endothelial Protein C Receptor/genetics ; Humans ; Immunity, Innate ; Lupus Erythematosus, Systemic/blood ; Mice ; Mice, Mutant Strains ; Sphingomyelin Phosphodiesterase/metabolism ; Thrombosis/immunology ; Toll-Like Receptor 7/immunology
Czasopismo naukowe
Tytuł :
A critical role of endothelial cell protein C receptor in the intestinal homeostasis in experimental colitis.
Autorzy :
Kondreddy V; Department of Cellular and Molecular Biology, The University of Texas Health Science Center At Tyler, 11937 US Highway 271, Tyler, TX, 75708-3154, USA.
Keshava S; Department of Cellular and Molecular Biology, The University of Texas Health Science Center At Tyler, 11937 US Highway 271, Tyler, TX, 75708-3154, USA.
Esmon CT; Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Pendurthi UR; Department of Cellular and Molecular Biology, The University of Texas Health Science Center At Tyler, 11937 US Highway 271, Tyler, TX, 75708-3154, USA.
Rao LVM; Department of Cellular and Molecular Biology, The University of Texas Health Science Center At Tyler, 11937 US Highway 271, Tyler, TX, 75708-3154, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 25; Vol. 10 (1), pp. 20569. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Colitis/*metabolism
Endothelial Protein C Receptor/*metabolism
Intestinal Mucosa/*metabolism
Animals ; Colitis, Ulcerative/metabolism ; Colon/metabolism ; Crohn Disease/metabolism ; Cytokines/metabolism ; Dextran Sulfate/adverse effects ; Dextran Sulfate/pharmacology ; Disease Models, Animal ; Endothelial Cells/metabolism ; Endothelial Protein C Receptor/physiology ; Female ; Homeostasis/physiology ; Inflammation/metabolism ; Intestines/physiopathology ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Permeability
Czasopismo naukowe
Tytuł :
EPCR deficiency or function-blocking antibody protects against joint bleeding-induced pathology in hemophilia mice.
Autorzy :
Magisetty J; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX; and.
Pendurthi UR; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX; and.
Esmon CT; Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK.
Rao LVM; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX; and.
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Źródło :
Blood [Blood] 2020 Jun 18; Vol. 135 (25), pp. 2211-2223.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antibodies, Monoclonal/*therapeutic use
Endothelial Protein C Receptor/*deficiency
Hemarthrosis/*prevention & control
Hemophilia A/*complications
Animals ; Antibodies, Monoclonal/pharmacology ; Cytokines/physiology ; Endothelial Protein C Receptor/antagonists & inhibitors ; Endothelial Protein C Receptor/immunology ; Endothelial Protein C Receptor/physiology ; Factor VIIa/therapeutic use ; Hemarthrosis/drug therapy ; Hemarthrosis/etiology ; Hemarthrosis/physiopathology ; Hemophilia A/drug therapy ; Hemophilia A/genetics ; Mice ; Mice, Knockout ; Punctures/adverse effects ; Rats ; Recombinant Proteins/therapeutic use ; Synovitis/etiology ; Synovitis/prevention & control
Czasopismo naukowe
Tytuł :
Elevated levels of soluble Endothelial protein C receptor in rheumatoid arthritis and block the therapeutic effect of protein C in collagen-induced arthritis.
Autorzy :
Bai L; Department of Rheumatology, The First Affiliated Hospital of Baotou Medical College, Baotou 014010, China; Institute of Immunology and Rheumatology, Baotou Medical College (Inner Mongolia Key Laboratory of Autoimmunity), Baotou 014010, China; Baotou Medical College, Baotou 014010, China.
Liu W; Department of Rheumatology, The First Affiliated Hospital of Baotou Medical College, Baotou 014010, China; Baotou Medical College, Baotou 014010, China.
Guo P; Department of Orthopedic, The First Affiliated Hospital of Baotou Medical College, Baotou 014010, China.
Bai J; Department of Rheumatology, The First Affiliated Hospital of Baotou Medical College, Baotou 014010, China; Baotou Medical College, Baotou 014010, China.
Liu Y; Department of Rheumatology, The First Affiliated Hospital of Baotou Medical College, Baotou 014010, China; Baotou Medical College, Baotou 014010, China.
Hua Y; Department of Rheumatology, The First Affiliated Hospital of Baotou Medical College, Baotou 014010, China; Baotou Medical College, Baotou 014010, China.
Pang C; Department of Rheumatology, The First Affiliated Hospital of Baotou Medical College, Baotou 014010, China; Institute of Immunology and Rheumatology, Baotou Medical College (Inner Mongolia Key Laboratory of Autoimmunity), Baotou 014010, China; Baotou Medical College, Baotou 014010, China.
Zhang W; Department of Rheumatology, The First Affiliated Hospital of Baotou Medical College, Baotou 014010, China; Institute of Immunology and Rheumatology, Baotou Medical College (Inner Mongolia Key Laboratory of Autoimmunity), Baotou 014010, China; Baotou Medical College, Baotou 014010, China.
Yin F; Department of Rheumatology, The First Affiliated Hospital of Baotou Medical College, Baotou 014010, China; Institute of Immunology and Rheumatology, Baotou Medical College (Inner Mongolia Key Laboratory of Autoimmunity), Baotou 014010, China; Baotou Medical College, Baotou 014010, China.
Wang Y; Department of Rheumatology, The First Affiliated Hospital of Baotou Medical College, Baotou 014010, China; Institute of Immunology and Rheumatology, Baotou Medical College (Inner Mongolia Key Laboratory of Autoimmunity), Baotou 014010, China; Baotou Medical College, Baotou 014010, China. Electronic address: .
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2020 Apr; Vol. 81, pp. 106255. Date of Electronic Publication: 2020 Jan 30.
Typ publikacji :
Journal Article
MeSH Terms :
Arthritis, Experimental/*metabolism
Arthritis, Rheumatoid/*metabolism
Endothelial Protein C Receptor/*metabolism
Osteoarthritis/*metabolism
Th17 Cells/*immunology
Adult ; Aged ; Animals ; Arthritis, Experimental/pathology ; Arthritis, Rheumatoid/pathology ; CTLA-4 Antigen/metabolism ; Cell Differentiation ; Endothelial Protein C Receptor/genetics ; Female ; Gene Expression Regulation ; Humans ; Male ; Mice, Inbred DBA ; Middle Aged ; Osteoarthritis/pathology ; Programmed Cell Death 1 Receptor/metabolism ; Protein C/antagonists & inhibitors ; Protein C/metabolism
Czasopismo naukowe
Tytuł :
Pig endothelial protein C receptor is functionally compatible with the human protein C pathway.
Autorzy :
Salvaris EJ; Immunology Research Centre, St. Vincent's Hospital Melbourne, Victoria, Australia.
Moran CJ; Immunology Research Centre, St. Vincent's Hospital Melbourne, Victoria, Australia.
Roussel JC; Immunology Research Centre, St. Vincent's Hospital Melbourne, Victoria, Australia.
Fisicaro N; Immunology Research Centre, St. Vincent's Hospital Melbourne, Victoria, Australia.
Robson SC; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Cowan PJ; Immunology Research Centre, St. Vincent's Hospital Melbourne, Victoria, Australia.; Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
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Źródło :
Xenotransplantation [Xenotransplantation] 2020 Mar; Vol. 27 (2), pp. e12557. Date of Electronic Publication: 2019 Sep 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Animals, Genetically Modified/*immunology
Endothelial Cells/*metabolism
Endothelial Protein C Receptor/*metabolism
Protein C/*metabolism
Animals ; Blood Coagulation/physiology ; Endothelial Protein C Receptor/genetics ; Swine ; Transplantation, Heterologous/methods
Czasopismo naukowe
Tytuł :
SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung.
Autorzy :
Mast AE; Versiti Blood Research Institute, Department of Cell Biology Neurobiology and Anatomy Medical College of Wisconsin, Milwaukee, United States.
Wolberg AS; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, Chapel Hill, United States.
Gailani D; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, United States.
Garvin MR; Oak Ridge National Laboratory, Biosciences Division, Oak Ridge, United States.
Alvarez C; Oak Ridge National Laboratory, Biosciences Division, Oak Ridge, United States.
Miller JI; Oak Ridge National Laboratory, Biosciences Division, Oak Ridge, United States.
Aronow B; University of Tennessee Knoxville, The Bredesen Center for Interdisciplinary Research and Graduate Education, Knoxville, United States.; Biomedical Informatics, Cincinnati Children's Hospital Research Foundation, Cincinnati, United States.; University of Cincinnati, Cincinnati, United States.
Jacobson D; Oak Ridge National Laboratory, Biosciences Division, Oak Ridge, United States.; University of Tennessee Knoxville, The Bredesen Center for Interdisciplinary Research and Graduate Education, Knoxville, United States.; University of Tennessee Knoxville, Department of Psychology, Knoxville, United States.
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Źródło :
ELife [Elife] 2021 Mar 08; Vol. 10. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
SARS-CoV-2*
Blood Coagulation/*genetics
COVID-19/*pathology
Fibrin/*genetics
Lung/*pathology
Anticoagulants/metabolism ; Bronchoalveolar Lavage Fluid ; COVID-19/genetics ; COVID-19/metabolism ; Endothelial Protein C Receptor/genetics ; Endothelial Protein C Receptor/metabolism ; Fibrin/metabolism ; Gene Expression ; Humans ; Kallikrein-Kinin System/genetics ; Kallikreins/genetics ; Kallikreins/metabolism ; Kinins/genetics ; Kinins/metabolism ; Lung/metabolism ; RNA, Messenger/metabolism ; Sequence Analysis, RNA ; Thrombomodulin/genetics ; Thrombomodulin/metabolism ; Urokinase-Type Plasminogen Activator/genetics ; Urokinase-Type Plasminogen Activator/metabolism
Czasopismo naukowe
Tytuł :
CD34 and EPCR coordinately enrich functional murine hematopoietic stem cells under normal and inflammatory conditions.
Autorzy :
Rabe JL; Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Hernandez G; Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Chavez JS; Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Mills TS; Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Nerlov C; MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Pietras EM; Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA; Department of Immunology & Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address: .
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Źródło :
Experimental hematology [Exp Hematol] 2020 Jan; Vol. 81, pp. 1-15.e6. Date of Electronic Publication: 2019 Dec 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Proliferation*
Hematopoiesis*
Stress, Physiological*
Antigens, CD34/*metabolism
Endothelial Protein C Receptor/*metabolism
Hematopoietic Stem Cells/*metabolism
Animals ; Antigens, CD34/genetics ; Endothelial Protein C Receptor/genetics ; Hematopoietic Stem Cells/pathology ; Inflammation/chemically induced ; Inflammation/metabolism ; Inflammation/pathology ; Interleukin-1/adverse effects ; Interleukin-1/pharmacology ; Mice ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers.
Autorzy :
Wang D; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Hu X; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Liu C; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Jia Y; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Bai Y; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Cai C; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Wang J; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Bai L; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Yang R; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Lin C; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Liu YR; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Li S; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Qiao F; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Yao L; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Chen L; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Ge G; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Jiang H; Key Laboratory of Systems Biology, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200032, China.
Li D; State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Li L; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Chen J; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Shao ZM; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. .
Zeng YA; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. .
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Źródło :
Cell research [Cell Res] 2019 Oct; Vol. 29 (10), pp. 832-845. Date of Electronic Publication: 2019 Sep 03.
Typ publikacji :
Journal Article
MeSH Terms :
Endothelial Protein C Receptor/*metabolism
Neoplastic Stem Cells/*metabolism
Triple Negative Breast Neoplasms/*pathology
Animals ; BRCA1 Protein/genetics ; BRCA1 Protein/metabolism ; Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Endothelial Protein C Receptor/antagonists & inhibitors ; Endothelial Protein C Receptor/genetics ; Female ; Humans ; Kaplan-Meier Estimate ; Mice ; Mice, Nude ; Mice, SCID ; Mutation ; Neoplastic Stem Cells/immunology ; RNA Interference ; RNA, Small Interfering/metabolism ; Single-Domain Antibodies/immunology ; Single-Domain Antibodies/pharmacology ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/mortality
Czasopismo naukowe
Tytuł :
Linking clotting and autoimmunity.
Autorzy :
Kaplan MJ; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, MD 20892, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2021 Mar 12; Vol. 371 (6534), pp. 1100-1101.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Autoimmunity*
Blood Coagulation*
Endothelial Protein C Receptor ; Lipids
Czasopismo naukowe
Tytuł :
Procr-expressing progenitor cells are responsible for murine ovulatory rupture repair of ovarian surface epithelium.
Autorzy :
Wang J; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Wang D; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Chu K; Reproductive Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.
Li W; Reproductive Medicine Center, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China. .
Zeng YA; State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. .
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Źródło :
Nature communications [Nat Commun] 2019 Oct 31; Vol. 10 (1), pp. 4966. Date of Electronic Publication: 2019 Oct 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ovulation*
Adult Stem Cells/*physiology
Endothelial Protein C Receptor/*genetics
Epithelial Cells/*physiology
Epithelium/*physiology
Ovary/*physiology
Re-Epithelialization/*physiology
Adult Stem Cells/metabolism ; Animals ; Cell Self Renewal ; Endothelial Protein C Receptor/metabolism ; Epithelial Cells/metabolism ; Epithelium/metabolism ; Female ; Gene Knock-In Techniques ; Mice ; Ovary/cytology ; Ovary/metabolism ; Receptors, G-Protein-Coupled/metabolism
Czasopismo naukowe
Tytuł :
Embryonic lineage tracing with Procr-CreER marks balanced hematopoietic stem cell fate during entire mouse lifespan.
Autorzy :
Zheng X; State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing, 100071, China.
Zhang G; State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing, 100071, China.
Gong Y; State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing, 100071, China.
Ning X; State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing, 100071, China.
Bai Z; State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing, 100071, China.
He J; State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing, 100071, China.
Zhou F; Beijing Advanced Innovation Center for Genomics, Department of Obstetrics and Gynecology, Third Hospital, School of Life Sciences, Peking University, Beijing, China; Biomedical Pioneering Innovation Center and Center for Reproductive Medicine, Third Hospital, Peking University, Beijing, China.
Ni Y; State Key Laboratory of Experimental Hematology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100071, China.
Lan Y; Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL); Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, 510632, China. Electronic address: .
Liu B; State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing, 100071, China; State Key Laboratory of Experimental Hematology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100071, China; Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL); Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, 510632, China; State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, 300020, China. Electronic address: .
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Źródło :
Journal of genetics and genomics = Yi chuan xue bao [J Genet Genomics] 2019 Oct 20; Vol. 46 (10), pp. 489-498. Date of Electronic Publication: 2019 Nov 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelial Protein C Receptor/*metabolism
Hematopoietic Stem Cells/*metabolism
Animals ; Aorta/cytology ; Aorta/metabolism ; Embryo, Mammalian ; Endothelial Protein C Receptor/genetics ; Female ; Hematopoiesis/genetics ; Hematopoiesis/physiology ; Hematopoietic Stem Cells/cytology ; Male ; Mesonephros/cytology ; Mesonephros/metabolism ; Mice ; Platelet Endothelial Cell Adhesion Molecule-1/genetics ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism
Czasopismo naukowe
Tytuł :
Binding Heterogeneity of Plasmodium falciparum to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1.
Autorzy :
Bernabeu M; Seattle Children's Research Institute, Seattle, Washington, USA.
Gunnarsson C; Department of Bioengineering, University of Washington, Seattle, Washington, USA.
Vishnyakova M; Seattle Children's Research Institute, Seattle, Washington, USA.
Howard CC; Department of Bioengineering, University of Washington, Seattle, Washington, USA.
Nagao RJ; Department of Bioengineering, University of Washington, Seattle, Washington, USA.
Avril M; Seattle Children's Research Institute, Seattle, Washington, USA.
Taylor TE; Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi.; Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA.
Seydel KB; Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi.; Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA.
Zheng Y; Department of Bioengineering, University of Washington, Seattle, Washington, USA .; Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA.
Smith JD; Seattle Children's Research Institute, Seattle, Washington, USA .; Department of Global Health, University of Washington, Seattle, Washington, USA.
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Źródło :
MBio [mBio] 2019 May 28; Vol. 10 (3). Date of Electronic Publication: 2019 May 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Cell Adhesion*
Brain/*parasitology
Endothelial Protein C Receptor/*metabolism
Erythrocytes/*parasitology
Intercellular Adhesion Molecule-1/*metabolism
Microvessels/*parasitology
Plasmodium falciparum/*physiology
Binding Sites ; Brain/cytology ; Cell Culture Techniques ; Cells, Cultured ; Endothelial Cells/parasitology ; Endothelial Protein C Receptor/genetics ; Erythrocytes/physiology ; Humans ; Intercellular Adhesion Molecule-1/genetics ; Malaria, Cerebral/parasitology ; Malaria, Cerebral/physiopathology ; Malaria, Falciparum/parasitology ; Microvessels/cytology ; Protozoan Proteins/metabolism ; Receptors, Cell Surface/metabolism ; Tissue Engineering/methods ; Tumor Necrosis Factor-alpha/immunology
Czasopismo naukowe
Tytuł :
Endothelial protein C receptor (EPCR) expression marks human fetal liver hematopoietic stem cells.
Autorzy :
Subramaniam A; Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Sweden.
Talkhoncheh MS; Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Sweden.
Magnusson M; Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Sweden.
Larsson J; Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Sweden .
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Źródło :
Haematologica [Haematologica] 2019 Feb; Vol. 104 (2), pp. e47-e50. Date of Electronic Publication: 2018 Jul 19.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression*
Endothelial Protein C Receptor/*genetics
Hematopoietic Stem Cells/*metabolism
Liver/*cytology
Liver/*metabolism
Biomarkers ; Endothelial Protein C Receptor/metabolism ; Humans ; Immunophenotyping
Raport
Tytuł :
Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity.
Autorzy :
Fager AM; Division of Hematology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.; Pathology and Laboratory Medicine Service, Durham Veterans Affairs Medical Center, Durham, NC, USA.
Machlus KR; Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Ezban M; Pharmacology, Novo Nordisk A/S, Måløv, Denmark.
Hoffman M; Pathology and Laboratory Medicine Service, Durham Veterans Affairs Medical Center, Durham, NC, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, USA.
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Źródło :
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2018 Sep; Vol. 16 (9), pp. 1817-1829. Date of Electronic Publication: 2018 Jun 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Platelet Activation*
Blood Platelets/*metabolism
Endothelial Protein C Receptor/*blood
Factor VIIa/*metabolism
Adult ; Binding, Competitive ; Carrier Proteins/pharmacology ; Crotalid Venoms/pharmacology ; Endothelial Cells/metabolism ; Endothelial Protein C Receptor/biosynthesis ; Factor VIIa/genetics ; Factor Xa/biosynthesis ; Hemostasis ; Humans ; Lectins, C-Type ; Peptides/pharmacology ; Protein Binding ; Protein C/metabolism
Czasopismo naukowe
Tytuł :
An early increase in endothelial protein C receptor is associated with excess mortality in pneumococcal pneumonia with septic shock in the ICU.
Autorzy :
Chapelet A; Medical Intensive Care Unit, Nantes University Hospital, Nantes, France.; Centre for Research in Transplantation and Immunology (CRTI) UMR1064, INSERM, Nantes University, Nantes, France.; Institute of Transplantation Urology Nephrology (ITUN), Nantes University Hospital, Nantes, France.
Foucher Y; INSERM, UMR 1246 - SPHERE, Nantes University, Nantes University Hospital, Nantes, France.
Gérard N; Centre for Research in Transplantation and Immunology (CRTI) UMR1064, INSERM, Nantes University, Nantes, France.
Rousseau C; Institut Cochin, INSERM U1016, Paris, France.
Zambon O; Medical Intensive Care Unit, Nantes University Hospital, Nantes, France.
Bretonnière C; Medical Intensive Care Unit, Nantes University Hospital, Nantes, France.
Mira JP; Institut Cochin, INSERM U1016, Paris, France.; Medical Intensive Care Unit, Cochin University Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.
Charreau B; Centre for Research in Transplantation and Immunology (CRTI) UMR1064, INSERM, Nantes University, Nantes, France.; Institute of Transplantation Urology Nephrology (ITUN), Nantes University Hospital, Nantes, France.
Guitton C; Medical Intensive Care Unit, Nantes University Hospital, Nantes, France. .; Centre for Research in Transplantation and Immunology (CRTI) UMR1064, INSERM, Nantes University, Nantes, France. .; Medical and Surgical Intensive Care Unit, Le Mans Hospital, Le Mans, France. .
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Źródło :
Critical care (London, England) [Crit Care] 2018 Oct 05; Vol. 22 (1), pp. 251. Date of Electronic Publication: 2018 Oct 05.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelial Protein C Receptor/*analysis
Pneumonia, Pneumococcal/*mortality
Shock, Septic/*blood
Aged ; Aged, 80 and over ; Biomarkers/analysis ; Biomarkers/blood ; Endothelial Protein C Receptor/blood ; Enzyme-Linked Immunosorbent Assay/methods ; Female ; France/epidemiology ; Hospital Mortality ; Humans ; Intensive Care Units/organization & administration ; Intensive Care Units/statistics & numerical data ; Male ; Middle Aged ; Pneumonia, Pneumococcal/blood ; Pneumonia, Pneumococcal/epidemiology ; Polymorphism, Single Nucleotide ; Prospective Studies ; ROC Curve ; Research Design ; Risk Factors ; Shock, Septic/epidemiology ; Shock, Septic/mortality
Czasopismo naukowe
Tytuł :
Podocyte Integrin- β and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy.3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy.
Autorzy :
Madhusudhan T; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany .; Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany.
Ghosh S; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.
Wang H; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dong W; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Gupta D; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.
Elwakiel A; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.
Stoyanov S; German Center for Neurodegenerative Diseases, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Al-Dabet MM; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.; Department of Medical Laboratories, Faculty of Health Sciences, American University of Madaba, Amman, Jordan.
Krishnan S; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.
Biemann R; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.
Nazir S; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Zimmermann S; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.
Mathew A; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.
Gadi I; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.
Rana R; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.
Zeng-Brouwers J; Institute of Pharmacology, University Hospital and Goethe University, Frankfurt, Germany.
Moeller MJ; Division of Nephrology and Immunology, University Hospital of the Rheinisch-Westfälische Technische Hochschule, Aachen University of Technology, Aachen, Germany.
Schaefer L; Institute of Pharmacology, University Hospital and Goethe University, Frankfurt, Germany.
Esmon CT; Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Kohli S; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany.; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.
Reiser J; Department of Medicine, Rush University Medical Center, Chicago, Illinois.
Rezaie AR; Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Ruf W; Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California.
Isermann B; Institute of Clinical Chemistry and Pathobiochemistry, Otto von Guericke University Magdeburg, Magdeburg, Germany .; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.
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Źródło :
Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2020 Aug; Vol. 31 (8), pp. 1762-1780. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetic Nephropathies/*prevention & control
Integrin beta3/*physiology
Podocytes/*physiology
Protein C/*physiology
rhoA GTP-Binding Protein/*physiology
Animals ; Cytoprotection ; Endothelial Protein C Receptor/physiology ; GTP-Binding Protein alpha Subunits, G12-G13/physiology ; HEK293 Cells ; Humans ; Mice ; Mice, Inbred C57BL ; Receptor, PAR-1/physiology
Czasopismo naukowe
Tytuł :
Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1.
Autorzy :
Kondreddy V; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX; and.
Wang J; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX; and.
Keshava S; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX; and.
Esmon CT; Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK.
Rao LVM; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX; and.
Pendurthi UR; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX; and.
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Źródło :
Blood [Blood] 2018 May 24; Vol. 131 (21), pp. 2379-2392. Date of Electronic Publication: 2018 Apr 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Signal Transduction*
Endothelial Protein C Receptor/*metabolism
Factor VIIa/*metabolism
Inflammation/*metabolism
Receptor, PAR-1/*metabolism
Animals ; Biomarkers ; Endothelial Protein C Receptor/genetics ; Gene Expression Regulation ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Inflammation/genetics ; Inflammation Mediators/metabolism ; Lipopolysaccharides/adverse effects ; Lipopolysaccharides/immunology ; Mice ; Receptor, PAR-1/genetics ; Tumor Necrosis Factor-alpha/metabolism ; beta-Arrestins/metabolism
Czasopismo naukowe
Tytuł :
An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans.
Autorzy :
Lécuyer H; Institut Necker Enfants Malades, INSERM U1151, CNRS UMR8253, Paris, France.; Université Paris Descartes, Paris, France.; Assistance Publique-Hôpitaux de Paris, Hôpital Universitaire Necker Enfants Malades, Service de Microbiologie Clinique, Paris, France.
Virion Z; Institut Necker Enfants Malades, INSERM U1151, CNRS UMR8253, Paris, France.; Université Paris Descartes, Paris, France.
Barnier JP; Institut Necker Enfants Malades, INSERM U1151, CNRS UMR8253, Paris, France.; Université Paris Descartes, Paris, France.; Assistance Publique-Hôpitaux de Paris, Hôpital Universitaire Necker Enfants Malades, Service de Microbiologie Clinique, Paris, France.
Matczak S; Institut Necker Enfants Malades, INSERM U1151, CNRS UMR8253, Paris, France.; Université Paris Descartes, Paris, France.
Bourdoulous S; Université Paris Descartes, Paris, France.; Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.
Bianchini E; INSERM UMR-S1176, Université Paris-Sud, Université Paris Saclay, Le Kremlin-Bicêtre, France.
Saller F; INSERM UMR-S1176, Université Paris-Sud, Université Paris Saclay, Le Kremlin-Bicêtre, France.
Borgel D; INSERM UMR-S1176, Université Paris-Sud, Université Paris Saclay, Le Kremlin-Bicêtre, France.; Assistance Publique-Hôpitaux de Paris, Hôpital Universitaire Necker Enfants Malades, Service d'Hématologie Biologique, Paris, France.
Nassif X; Institut Necker Enfants Malades, INSERM U1151, CNRS UMR8253, Paris, France.; Université Paris Descartes, Paris, France.; Assistance Publique-Hôpitaux de Paris, Hôpital Universitaire Necker Enfants Malades, Service de Microbiologie Clinique, Paris, France.
Coureuil M; Institut Necker Enfants Malades, INSERM U1151, CNRS UMR8253, Paris, France.; Université Paris Descartes, Paris, France.
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Źródło :
PLoS pathogens [PLoS Pathog] 2018 Apr 09; Vol. 14 (4), pp. e1006981. Date of Electronic Publication: 2018 Apr 09 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
ADAM10 Protein/*metabolism
Amyloid Precursor Protein Secretases/*metabolism
Endothelial Protein C Receptor/*metabolism
Endothelium, Vascular/*pathology
Membrane Proteins/*metabolism
Meningococcal Infections/*complications
Microvessels/*pathology
Protein C/*metabolism
Purpura Fulminans/*etiology
ADAM10 Protein/genetics ; Amyloid Precursor Protein Secretases/genetics ; Bacterial Adhesion ; Blood Coagulation/physiology ; Cells, Cultured ; Endothelial Protein C Receptor/genetics ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/microbiology ; Humans ; Membrane Proteins/genetics ; Meningococcal Infections/microbiology ; Microvessels/metabolism ; Microvessels/microbiology ; Neisseria meningitidis/physiology ; Protein C/genetics ; Purpura Fulminans/metabolism ; Purpura Fulminans/pathology
Czasopismo naukowe
Tytuł :
Knockdown of EPCR inhibits the proliferation and migration of human gastric cancer cells via the ERK1/2 pathway in a PAR-1-dependent manner.
Autorzy :
Wang Q; Department of Pathology, Xuzhou Medical University, and Jiangsu Key Laboratory of Immunity and Metabolism, Xuzhou, Jiangsu 221004, P.R. China.
Yang H; Department of Pathology, Xuzhou Medical University, and Jiangsu Key Laboratory of Immunity and Metabolism, Xuzhou, Jiangsu 221004, P.R. China.
Zhuo Q; Department of Pathology, Xuzhou Medical University, and Jiangsu Key Laboratory of Immunity and Metabolism, Xuzhou, Jiangsu 221004, P.R. China.
Xu Y; Department of Pathology, Xuzhou Medical University, and Jiangsu Key Laboratory of Immunity and Metabolism, Xuzhou, Jiangsu 221004, P.R. China.
Zhang P; Department of Pathology, Xuzhou Medical University, and Jiangsu Key Laboratory of Immunity and Metabolism, Xuzhou, Jiangsu 221004, P.R. China.
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Źródło :
Oncology reports [Oncol Rep] 2018 Apr; Vol. 39 (4), pp. 1843-1852. Date of Electronic Publication: 2018 Feb 21.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*genetics
Endothelial Protein C Receptor/*genetics
Receptor, PAR-1/*genetics
Stomach Neoplasms/*genetics
Apoptosis/genetics ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Endothelial Protein C Receptor/antagonists & inhibitors ; Gene Expression Regulation, Neoplastic ; Humans ; MAP Kinase Signaling System/genetics ; RNA, Small Interfering/genetics ; Receptor, PAR-1/antagonists & inhibitors ; Stomach Neoplasms/pathology
Czasopismo naukowe

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