Temat: "Endothelin Receptor Antagonists" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Endothelin Receptor Antagonists in Kidney Disease.
Autorzy:: Martínez-Díaz I; Nephrology and Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Martos N; Nephrology and Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Llorens-Cebrià C; Nephrology and Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Álvarez FJ; Travere Therapeutics, Inc., San Diego, CA 92130, USA.
Bedard PW; Travere Therapeutics, Inc., San Diego, CA 92130, USA.
Vergara A; Nephrology and Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Jacobs-Cachá C; Nephrology and Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Soler MJ; Nephrology and Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 08; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 08.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Endothelin Receptor Antagonists*
Kidney Diseases*/drug therapy
Humans ; Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Endothelin A Receptor Antagonists ; Endothelin-1 ; Endothelins ; Kidney ; Proteinuria/drug therapy ; Receptor, Endothelin A

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Skocz do pozycji: 2.

Tytuł:: Single-dose pharmacokinetics, safety, and tolerability of the dual endothelin receptor antagonist aprocitentan in subjects with moderate hepatic impairment.
Autorzy:: Fontes MSC; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
Dingemanse J; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
Halabi A; Clinical Research Services Kiel GmbH, Kiel, Germany.
Tomaszewska-Kiecana M; Biokinetica S.A., Józefów, Poland.
Sidharta PN; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123, Allschwil, Switzerland. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Nov 09; Vol. 12 (1), pp. 19067. Date of Electronic Publication: 2022 Nov 09.
Typ publikacji:: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Endothelin Receptor Antagonists*/adverse effects
Liver Diseases*/drug therapy
Liver Diseases*/metabolism
Humans ; Area Under Curve ; Pyrimidines ; Sulfonamides

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Skocz do pozycji: 3.

Tytuł:: Comparative assessment of efficacy and safety of ambrisentan and bosentan in patients with pulmonary arterial hypertension: A meta-analysis.
Autorzy:: Zhao Q; Department of Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Guo N; GlaxoSmithKline, Beijing, China.
Chen J; GlaxoSmithKline, Beijing, China.
Parks D; GlaxoSmithKline, Collegeville, PA, USA.
Tian Z; Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Pokaż więcej
Źródło:: Journal of clinical pharmacy and therapeutics [J Clin Pharm Ther] 2022 Feb; Vol. 47 (2), pp. 146-156. Date of Electronic Publication: 2021 Jul 28.
Typ publikacji:: Journal Article; Meta-Analysis; Review
MeSH Terms:: Antihypertensive Agents/*therapeutic use
Bosentan/*therapeutic use
Endothelin Receptor Antagonists/*therapeutic use
Phenylpropionates/*therapeutic use
Pulmonary Arterial Hypertension/*drug therapy
Pyridazines/*therapeutic use
Antihypertensive Agents/administration & dosage ; Antihypertensive Agents/adverse effects ; Bosentan/administration & dosage ; Bosentan/adverse effects ; Endothelin Receptor Antagonists/administration & dosage ; Endothelin Receptor Antagonists/adverse effects ; Humans ; Liver Function Tests ; Network Meta-Analysis ; Phenylpropionates/administration & dosage ; Phenylpropionates/adverse effects ; Pyridazines/administration & dosage ; Pyridazines/adverse effects ; Randomized Controlled Trials as Topic ; Walk Test

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Skocz do pozycji: 4.

Tytuł:: A case-control study of phosphodiesterase-5 inhibitor use and Alzheimer's disease and related dementias among male and female patients aged 65 years and older supporting the need for a phase III clinical trial.
Autorzy:: Henry DS; Baptist Health Center for Clinical Research, Little Rock, Arkansas, United States of America.
Pellegrino RG; Baptist Health Center for Clinical Research, Little Rock, Arkansas, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Oct 18; Vol. 18 (10), pp. e0292863. Date of Electronic Publication: 2023 Oct 18 (Print Publication: 2023).
Typ publikacji:: Journal Article
MeSH Terms:: Alzheimer Disease*/drug therapy
Alzheimer Disease*/chemically induced
Hypertension, Pulmonary*/drug therapy
Aged ; Female ; Humans ; Male ; Case-Control Studies ; Cyclic Nucleotide Phosphodiesterases, Type 5 ; Endothelin Receptor Antagonists/therapeutic use ; Phosphodiesterase 5 Inhibitors/therapeutic use ; Sildenafil Citrate/therapeutic use ; Tadalafil/therapeutic use

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Skocz do pozycji: 5.

Tytuł:: Insulin resistance, kidney outcomes and effects of the endothelin receptor antagonist atrasentan in patients with type 2 diabetes and chronic kidney disease.
Autorzy:: Smeijer JD; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Kohan DE; Division of Nephrology, University of Utah Health, Salt Lake City, UT, USA.
Rossing P; Steno Diabetes Center Copenhagen, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Correa-Rotter R; National Medical Science and Nutrition Institute Salvador Zubirán, Mexico City, Mexico.
Liew A; Mount Elizabeth Novena Hospital, Singapore, Singapore.; George Institute for Global Health, Newtown, Australia.
Tang SCW; Division of Nephrology, Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
de Zeeuw D; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Gansevoort RT; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Ju W; Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.
Lambers Heerspink HJ; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. .; George Institute for Global Health, Newtown, Australia. .; Pokaż więcej
Źródło:: Cardiovascular diabetology [Cardiovasc Diabetol] 2023 Sep 16; Vol. 22 (1), pp. 251. Date of Electronic Publication: 2023 Sep 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Diabetes Mellitus, Type 2*/diagnosis
Diabetes Mellitus, Type 2*/drug therapy
Diabetes Mellitus, Type 2*/epidemiology
Insulin Resistance*
Renal Insufficiency, Chronic*/diagnosis
Renal Insufficiency, Chronic*/drug therapy
Renal Insufficiency, Chronic*/epidemiology
Humans ; Atrasentan/adverse effects ; Kidney ; Endothelin Receptor Antagonists/adverse effects

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Skocz do pozycji: 6.

Tytuł:: Insights into Endothelin Receptors in Pulmonary Hypertension.
Autorzy:: Liu R; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Yuan T; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Wang R; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Gong D; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Wang S; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Du G; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Fang L; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 16; Vol. 24 (12). Date of Electronic Publication: 2023 Jun 16.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Hypertension, Pulmonary*/drug therapy
Humans ; Receptors, Endothelin ; Endothelin Receptor Antagonists/therapeutic use ; Endothelin Receptor Antagonists/pharmacology ; Lung/metabolism ; Endothelins/pharmacology ; Endothelin-1

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Skocz do pozycji: 7.

Tytuł:: The Endothelin Receptor Antagonist Macitentan Inhibits Human Cytomegalovirus Infection.
Autorzy:: Landázuri N; Microbial Pathogenesis Unit, Department of Medicine Solna, Karolinska Institutet, SE-171 76 Stockholm, Sweden.; Division of Neurology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
Gorwood J; Microbial Pathogenesis Unit, Department of Medicine Solna, Karolinska Institutet, SE-171 76 Stockholm, Sweden.; Division of Neurology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
Terelius Y; Medivir AB, SE-141 22 Huddinge, Sweden.
Öberg F; Medivir AB, SE-141 22 Huddinge, Sweden.
Yaiw KC; Microbial Pathogenesis Unit, Department of Medicine Solna, Karolinska Institutet, SE-171 76 Stockholm, Sweden.; Division of Neurology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
Rahbar A; Microbial Pathogenesis Unit, Department of Medicine Solna, Karolinska Institutet, SE-171 76 Stockholm, Sweden.; Division of Neurology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
Söderberg-Nauclér C; Microbial Pathogenesis Unit, Department of Medicine Solna, Karolinska Institutet, SE-171 76 Stockholm, Sweden.; Division of Neurology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.; Pokaż więcej
Źródło:: Cells [Cells] 2021 Nov 08; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cytomegalovirus/*physiology
Endothelin Receptor Antagonists/*pharmacology
Pyrimidines/*pharmacology
Sulfonamides/*pharmacology
Cell Line ; Cytomegalovirus/drug effects ; Cytomegalovirus Infections/virology ; Endothelin Receptor Antagonists/chemistry ; Ganciclovir/pharmacology ; Humans ; Inhibitory Concentration 50 ; Metabolome ; Oligopeptides ; Piperidines ; Pyrimidines/chemistry ; Sulfonamides/chemistry ; Virion/drug effects ; Virion/metabolism ; Virus Internalization/drug effects ; Virus Replication/drug effects

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Skocz do pozycji: 8.

Tytuł:: Multiple-Dose Pharmacokinetics, Safety, and Tolerability of Aprocitentan, a Dual Endothelin Receptor Antagonist, in Healthy Japanese and Caucasian Subjects.
Autorzy:: Fontes MSC; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Dingemanse J; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Sidharta PN; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.; Pokaż więcej
Źródło:: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2021 Jul; Vol. 10 (7), pp. 718-725. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji:: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:: Asian People*
White People*
Endothelin Receptor Antagonists/*administration & dosage
Pyrimidines/*administration & dosage
Sulfonamides/*administration & dosage
Adult ; Area Under Curve ; Double-Blind Method ; Endothelin Receptor Antagonists/adverse effects ; Endothelin Receptor Antagonists/pharmacokinetics ; Female ; Half-Life ; Humans ; Male ; Pyrimidines/adverse effects ; Pyrimidines/pharmacokinetics ; Sulfonamides/adverse effects ; Sulfonamides/pharmacokinetics ; Young Adult

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Skocz do pozycji: 9.

Tytuł:: Advances in targeted therapy for pulmonary arterial hypertension in children.
Autorzy:: Li L; Department of Scientific Research, Gansu Provincial Hospital, 204 West Donggang R.D., Lanzhou, 730000, China.
Zhu X; Department of Scientific Research, Gansu Provincial Hospital, 204 West Donggang R.D., Lanzhou, 730000, China.
Chen X; Department of Scientific Research, Gansu Provincial Hospital, 204 West Donggang R.D., Lanzhou, 730000, China.
Gao J; Department of Scientific Research, Gansu Provincial Hospital, 204 West Donggang R.D., Lanzhou, 730000, China.
Ding C; Department of Pharmacy, Gansu Provincial Hospital, 204 West Donggang R.D., Lanzhou, 730000, China.
Zhang M; Department of Scientific Research, Gansu Provincial Hospital, 204 West Donggang R.D., Lanzhou, 730000, China. .
Ma S; First Clinical College of Medicine, Lanzhou University, 1st West Donggang R.D., Lanzhou, 730000, China. .; General Surgery, Gansu Provincial Hospital, 204 West Donggang R.D., Lanzhou, 730000, China. .; Pokaż więcej
Źródło:: European journal of pediatrics [Eur J Pediatr] 2023 May; Vol. 182 (5), pp. 2067-2076. Date of Electronic Publication: 2022 Dec 17.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Pulmonary Arterial Hypertension*/drug therapy
Pulmonary Arterial Hypertension*/complications
Pulmonary Arterial Hypertension*/diagnosis
Hypertension, Pulmonary*/drug therapy
Hypertension, Pulmonary*/etiology
Adult ; Child ; Humans ; Endothelin Receptor Antagonists/therapeutic use ; Phosphodiesterase 5 Inhibitors/therapeutic use ; Antihypertensive Agents/therapeutic use

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Skocz do pozycji: 10.

Tytuł:: Effects of Multiple-Dose Administration of Aprocitentan on the Pharmacokinetics of Rosuvastatin.
Autorzy:: Sidharta PN; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Dingemanse J; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.; Pokaż więcej
Źródło:: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2020 Nov; Vol. 9 (8), pp. 995-1002. Date of Electronic Publication: 2020 Jun 27.
Typ publikacji:: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anticholesteremic Agents/*pharmacokinetics
Endothelin Receptor Antagonists/*adverse effects
Pyrimidines/*adverse effects
Rosuvastatin Calcium/*pharmacokinetics
Sulfonamides/*adverse effects
ATP Binding Cassette Transporter, Subfamily G, Member 2/drug effects ; Administration, Oral ; Adult ; Anticholesteremic Agents/administration & dosage ; Anticholesteremic Agents/blood ; Area Under Curve ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Interactions/physiology ; Drug Therapy, Combination/adverse effects ; Drug Therapy, Combination/statistics & numerical data ; Drug Tolerance ; Endothelin Receptor Antagonists/administration & dosage ; Endothelin Receptor Antagonists/therapeutic use ; Healthy Volunteers/statistics & numerical data ; Humans ; Hypertension/drug therapy ; Male ; Middle Aged ; Neoplasm Proteins/drug effects ; Pyrimidines/administration & dosage ; Pyrimidines/therapeutic use ; Rosuvastatin Calcium/administration & dosage ; Rosuvastatin Calcium/blood ; Sulfonamides/administration & dosage ; Sulfonamides/therapeutic use

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Skocz do pozycji: 11.

Tytuł:: Endothelin receptor antagonists in kidney protection for diabetic kidney disease and beyond?
Autorzy:: Chung EYM; Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Badve SV; Renal and Metabolic Division, The George Institute for Global Health, University of New South Wales, Newtown, New South Wales, Australia.; Department of Renal Medicine, St George Hospital, Kogarah, New South Wales, Australia.
Heerspink HJL; Renal and Metabolic Division, The George Institute for Global Health, University of New South Wales, Newtown, New South Wales, Australia.; Department of Clinical Pharmacoy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Wong MG; Department of Renal Medicine, Concord Repatriation General Hospital, University of Sydney, Concord, New South Wales, Australia.; Pokaż więcej
Źródło:: Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2023 Feb; Vol. 28 (2), pp. 97-108. Date of Electronic Publication: 2022 Nov 15.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Diabetic Nephropathies*/drug therapy
Diabetic Nephropathies*/etiology
Diabetic Nephropathies*/prevention & control
Renal Insufficiency, Chronic*/complications
Renal Insufficiency, Chronic*/drug therapy
Diabetes Mellitus*/drug therapy
Humans ; Endothelin Receptor Antagonists/adverse effects ; Kidney ; Antihypertensive Agents/therapeutic use ; Angiotensin Receptor Antagonists/therapeutic use

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Skocz do pozycji: 12.

Tytuł:: Endothelin-1, endothelin receptor antagonists, and vein graft occlusion in coronary artery bypass surgery: 20 years on and still no journey from bench to bedside.
Autorzy:: Dashwood MR; Surgical and Interventional Sciences, Royal Free Hospital Campus, University College Medical School, London, United Kingdom.
Loesch A; Centre for Rheumatology, Royal Free Hospital Campus, University College Medical School, London, United Kingdom.; Pokaż więcej
Źródło:: Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2020 Sep; Vol. 98 (9), pp. 570-578. Date of Electronic Publication: 2020 Apr 28.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Coronary Artery Bypass/*adverse effects
Coronary Artery Disease/*surgery
Endothelin Receptor Antagonists/*therapeutic use
Endothelin-1/*metabolism
Graft Occlusion, Vascular/*etiology
Animals ; Cell Proliferation/drug effects ; Coronary Artery Bypass/methods ; Disease Models, Animal ; Drug Repositioning ; Endothelin Receptor Antagonists/pharmacology ; Endothelin-1/antagonists & inhibitors ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/immunology ; Endothelium, Vascular/pathology ; Endothelium, Vascular/surgery ; Graft Occlusion, Vascular/pathology ; Graft Occlusion, Vascular/prevention & control ; Graft Rejection ; Humans ; Saphenous Vein/drug effects ; Saphenous Vein/immunology ; Saphenous Vein/pathology ; Saphenous Vein/surgery ; Vascular Patency/drug effects

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Skocz do pozycji: 13.

Tytuł:: Topical application of endothelin receptor a antagonist attenuates imiquimod-induced psoriasiform skin inflammation.
Autorzy:: Nakahara T; Division of Skin Surface Sensing, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. .; Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. .
Kido-Nakahara M; Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ulzii D; Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Miake S; Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Fujishima K; Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Sakai S; Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Chiba T; Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; Department of Dermatology and Plastic Surgery, Akita University Graduate School of Medicine, Akita, Japan.
Tsuji G; Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; Research and Clinical Center for Yusho and Dioxin, Kyushu University, Fukuoka, Japan.
Furue M; Division of Skin Surface Sensing, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.; Research and Clinical Center for Yusho and Dioxin, Kyushu University, Fukuoka, Japan.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Jun 11; Vol. 10 (1), pp. 9510. Date of Electronic Publication: 2020 Jun 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Endothelin Receptor Antagonists/*administration & dosage
Endothelin Receptor Antagonists/*pharmacology
Imiquimod/*adverse effects
Psoriasis/*chemically induced
Psoriasis/*drug therapy
Receptors, Endothelin/*metabolism
Skin/*drug effects
Administration, Topical ; Animals ; Cytokines/metabolism ; Endothelin Receptor Antagonists/therapeutic use ; Endothelin-1/metabolism ; Gene Expression Regulation/drug effects ; Humans ; Mice ; Phenylpropionates/administration & dosage ; Phenylpropionates/pharmacology ; Phenylpropionates/therapeutic use ; Psoriasis/metabolism ; Psoriasis/prevention & control ; Pyridazines/administration & dosage ; Pyridazines/pharmacology ; Pyridazines/therapeutic use ; Skin/pathology

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Skocz do pozycji: 14.

Tytuł:: Predictive model of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hypertension.
Autorzy:: Yorifuji K; Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, 4-19-1 Motoyama-kitamachi, Higashinada, Kobe 658-8558, Japan.; The Shinko Institute for Medical Research, Shinko Hospital, 1-4-47, Wakinohama, Chuo, Kobe 651-0072, Japan.; Department of Pharmacy, Shinko Hospital, 1-4-47, Wakinohama, Chuo, Kobe 651-0072, Japan.
Uemura Y; The Shinko Institute for Medical Research, Shinko Hospital, 1-4-47, Wakinohama, Chuo, Kobe 651-0072, Japan.
Horibata S; The Shinko Institute for Medical Research, Shinko Hospital, 1-4-47, Wakinohama, Chuo, Kobe 651-0072, Japan.; Department of Pharmacy, Shinko Hospital, 1-4-47, Wakinohama, Chuo, Kobe 651-0072, Japan.
Tsuji G; The Shinko Institute for Medical Research, Shinko Hospital, 1-4-47, Wakinohama, Chuo, Kobe 651-0072, Japan.; Center for Rheumatic Diseases, Shinko Hospital, 1-4-47, Wakinohama, Chuo, Kobe 651-0072, Japan.
Suzuki Y; Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, 4-19-1 Motoyama-kitamachi, Higashinada, Kobe 658-8558, Japan.; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe Graduate School of Medicine, 7-5-1 Kusunoki, Chuo, Kobe 650-0017, Japan.
Nakayama K; Department of Cardiovascular Medicine, Shinko Hospital, 1-4-47, Wakinohama, Chuo, Kobe 651-0072, Japan.
Hatae T; Education and Research Center for Clinical Pharmacy, Kobe Pharmaceutical University, 4-19-1 Motoyama-kitamachi, Higashinada, Kobe 658-8558, Japan.
Kumagai S; The Shinko Institute for Medical Research, Shinko Hospital, 1-4-47, Wakinohama, Chuo, Kobe 651-0072, Japan.; Center for Rheumatic Diseases, Shinko Hospital, 1-4-47, Wakinohama, Chuo, Kobe 651-0072, Japan.
Emoto N; Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, 4-19-1 Motoyama-kitamachi, Higashinada, Kobe 658-8558, Japan.; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe Graduate School of Medicine, 7-5-1 Kusunoki, Chuo, Kobe 650-0017, Japan.; Pokaż więcej
Źródło:: Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2020 Sep; Vol. 98 (9), pp. 625-628. Date of Electronic Publication: 2020 May 20.
Typ publikacji:: Journal Article; Validation Study
MeSH Terms:: Models, Statistical*
Bosentan/*adverse effects
Chemical and Drug Induced Liver Injury/*epidemiology
Endothelin Receptor Antagonists/*adverse effects
Pulmonary Arterial Hypertension/*drug therapy
Adult ; Aged ; Aged, 80 and over ; Alleles ; Bosentan/pharmacokinetics ; Chemical and Drug Induced Liver Injury/blood ; Chemical and Drug Induced Liver Injury/genetics ; Chemical and Drug Induced Liver Injury/pathology ; Creatinine/blood ; Endothelin Receptor Antagonists/pharmacokinetics ; Female ; Humans ; Japan/epidemiology ; Liver/drug effects ; Liver/pathology ; Male ; Mutation ; Pharmacogenomic Variants ; Polymorphism, Single Nucleotide ; Predictive Value of Tests ; Pulmonary Arterial Hypertension/blood ; Pulmonary Arterial Hypertension/genetics ; Risk Assessment/methods ; Sulfotransferases/genetics ; Sulfotransferases/metabolism ; Carbohydrate Sulfotransferases

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Skocz do pozycji: 15.

Tytuł:: The endothelin receptor antagonist macitentan for the treatment of pulmonary arterial hypertension: A cross-species comparison of its cytochrome P450 induction pattern.
Autorzy:: Treiber A; Department of Non-Clinical Drug Metabolism and Pharmacokinetics, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Delahaye S; Department of Non-Clinical Drug Metabolism and Pharmacokinetics, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Seeland S; Department of Non-Clinical Drug Metabolism and Pharmacokinetics, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Gnerre C; Department of Non-Clinical Drug Metabolism and Pharmacokinetics, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2020 Aug; Vol. 8 (4), pp. e00619.
Typ publikacji:: Journal Article
MeSH Terms:: Cytochrome P-450 Enzyme Inducers/*pharmacology
Endothelin Receptor Antagonists/*pharmacology
Pyrimidines/*pharmacology
Sulfonamides/*pharmacology
Animals ; Cytochrome P-450 Enzyme Inducers/administration & dosage ; Dogs ; Dose-Response Relationship, Drug ; Drug Interactions ; Endothelin Receptor Antagonists/administration & dosage ; Enzyme Induction/drug effects ; Female ; Hepatocytes/metabolism ; Humans ; Male ; Pregnane X Receptor/drug effects ; Pregnane X Receptor/metabolism ; Pulmonary Arterial Hypertension/drug therapy ; Pyrimidines/administration & dosage ; Rats ; Rats, Sprague-Dawley ; Species Specificity ; Sulfonamides/administration & dosage

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Skocz do pozycji: 16.

Tytuł:: Enhanced Cardiorenal Protective Effects of Combining SGLT2 Inhibition, Endothelin Receptor Antagonism and RAS Blockade in Type 2 Diabetic Mice.
Autorzy:: Vergara A; Nephrology and Kidney Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.; Nephrology Department, Vall d'Hebron Hospital Universitari, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Jacobs-Cacha C; Nephrology and Kidney Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Llorens-Cebria C; Nephrology and Kidney Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Ortiz A; IIS-Fundación Jiménez Diaz, Fundación Renal Iñigo Álvarez de Toledo-IRSIN, REDinREN, Instituto de Investigación Carlos III, Universidad Autónoma de Madrid, Av. de los Reyes Católicos 2, 28040 Madrid, Spain.
Martinez-Diaz I; Nephrology and Kidney Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Martos N; Nephrology and Kidney Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Dominguez-Báez P; Nephrology and Kidney Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Van den Bosch MM; Nephrology and Kidney Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Bermejo S; Nephrology and Kidney Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.; Nephrology Department, Vall d'Hebron Hospital Universitari, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Pieper MP; Cardio-Metabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397 Biberach an der Riß, Germany.
Benito B; Cardiology Research Group, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.; Cardiology Department, Vall d'Hebron Hospital Universitari, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.; Deparment of Medicine, Universitat Autònoma de Barcelona, Av. de Can Domènech, 08193 Bellaterra, Spain.
Soler MJ; Nephrology and Kidney Transplantation Research Group, Vall d'Hebron Institut de Recerca (VHIR), Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.; Nephrology Department, Vall d'Hebron Hospital Universitari, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Oct 24; Vol. 23 (21). Date of Electronic Publication: 2022 Oct 24.
Typ publikacji:: Journal Article
MeSH Terms:: Renin-Angiotensin System*
Diabetes Mellitus, Type 2*/complications
Diabetes Mellitus, Type 2*/drug therapy
Mice ; Animals ; Sodium-Glucose Transporter 2 ; Atrasentan/pharmacology ; Endothelin Receptor Antagonists/pharmacology ; Blood Glucose ; Ramipril/pharmacology ; Receptors, Endothelin

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Skocz do pozycji: 17.

Tytuł:: Comparison of the protective effects of selective endothelin-a receptor antagonist, ambrisentan, and dual endothelin-A/B receptor antagonist, bosentan, in experimental renal ischemia reperfusion injury.
Autorzy:: Kazimoglu H
Uysal E
Dokur M
Gurer AO
Batcioglu K
Uyumlu BA
Petekkaya E
Karadag M; Pokaż więcej
Źródło:: Bratislavske lekarske listy [Bratisl Lek Listy] 2020; Vol. 121 (8), pp. 547-553.
Typ publikacji:: Journal Article
MeSH Terms:: Bosentan*/therapeutic use
Endothelin Receptor Antagonists*/therapeutic use
Phenylpropionates*/therapeutic use
Pyridazines*/therapeutic use
Reperfusion Injury*/drug therapy
Animals ; Endothelins ; Female ; Rats ; Receptor, Endothelin A ; Sulfonamides

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Skocz do pozycji: 18.

Tytuł:: Treatment of nonarteritic anterior ischemic optic neuropathy with an endothelin antagonist: ENDOTHELION (ENDOTHELin antagonist receptor in Ischemic Optic Neuropathy)-a multicentre randomised controlled trial protocol.
Autorzy:: Chiquet C; Department of Ophthalmology, Grenoble Alpes University Hospital, 38043, Grenoble, France. .; HP2 Laboratory, INSERM U1300, Grenoble Alpes University, Grenoble, France. .
Vignal C; Department of Ophthalmology, Adolphe de Rothschild Foundation Hospital, 75940, Paris Cedex 19, France.; Department of Ophthalmology and Internal Medicine, Quinze-Vingts National Hospital Centre for Ophthalmology, 75940, Paris, France.
Gohier P; Department of Ophthalmology, CHU de Angers, 49100, Angers, France.
Heron E; Department of Ophthalmology and Internal Medicine, Quinze-Vingts National Hospital Centre for Ophthalmology, 75940, Paris, France.
Thuret G; Department of Ophthalmology, CHU de Saint-Etienne, 42055, Saint-Etienne, France.
Rougier MB; Department of Ophthalmology, Hôpital Pellegrin, CHU de Bordeaux, 33000, Bordeaux, France.
Lehmann A; Department de Pharmacy, Grenoble-Alpes University Hospital, 38043, Grenoble, France.
Flet L; Department of Pharmacy, PTMC -Clinical Trials, CHU de Nantes, 44000, Nantes, France.
Quesada JL; Clinical Pharmacology Unit, Grenoble Alpes University Hospital, Grenoble, France.
Roustit M; HP2 Laboratory, INSERM U1300, Grenoble Alpes University, Grenoble, France.; Clinical Pharmacology Unit, Grenoble Alpes University Hospital, Grenoble, France.
Milea D; Visual Neuroscience Group, Singapore Eye Research Institute (SERI), Singapore National Eye Institute (SNEC), Duke-NUS Graduate Medical School, Singapore, Singapore.
Pepin JL; HP2 Laboratory, INSERM U1300, Grenoble Alpes University, Grenoble, France.; Pôle Thorax et Vaisseaux, Grenoble Alpes University Hospital, Grenoble, France.; Pokaż więcej
Corporate Authors:: ENDOTHELION group
Źródło:: Trials [Trials] 2022 Oct 29; Vol. 23 (1), pp. 916. Date of Electronic Publication: 2022 Oct 29.
Typ publikacji:: Clinical Trial Protocol; Journal Article
MeSH Terms:: Optic Neuropathy, Ischemic*/diagnosis
Optic Neuropathy, Ischemic*/drug therapy
Humans ; Middle Aged ; Retinal Ganglion Cells ; Bosentan/adverse effects ; Endothelin Receptor Antagonists/adverse effects ; Prospective Studies ; Receptors, Endothelin ; Tomography, Optical Coherence/methods ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic ; Clinical Trials, Phase III as Topic

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Skocz do pozycji: 19.

Tytuł:: Involvement of endothelins in neuroprotection of valosin-containing protein modulators against retinal ganglion cell damage.
Autorzy:: Kusaka M; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Hasegawa T; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. .; Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan. .
Ikeda HO; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. .
Inoue Y; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Iwai S; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Iida K; Medical Research Support Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Tsujikawa A; Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Sep 28; Vol. 12 (1), pp. 16156. Date of Electronic Publication: 2022 Sep 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: N-Methylaspartate*/metabolism
Retinal Ganglion Cells*/metabolism
Animals ; Endothelin Receptor Antagonists/pharmacology ; Endothelin-1/metabolism ; Mice ; Neuroprotection ; Tunicamycin/pharmacology ; Valosin Containing Protein/metabolism

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Skocz do pozycji: 20.

Tytuł:: Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension.
Autorzy:: Stapel JR; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Speed JS; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Clemmer JS; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.; Pokaż więcej
Źródło:: Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2022 Aug 01; Vol. 100 (8), pp. 828-833. Date of Electronic Publication: 2022 Jun 03.
Typ publikacji:: Journal Article
MeSH Terms:: Diabetes Mellitus, Type 2*/drug therapy
Hypertension, Pulmonary*/drug therapy
Insulin Resistance*
Animals ; Blood Glucose ; Endothelin Receptor Antagonists/therapeutic use ; Endothelins ; Glycated Hemoglobin/analysis ; Hypoglycemic Agents/therapeutic use ; Insulin ; Mice

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