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Tytuł :
Ex vivo Akt inhibition reverses castration induced internal pudendal artery and penile endothelial dysfunction.
Autorzy :
Odom MR; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA; Department of Surgery, Division of Urology, Duke University Medical Center, Durham, NC, USA.
Pak ES; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
Hannan JL; Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Nov 15; Vol. 285, pp. 119966. Date of Electronic Publication: 2021 Sep 17.
Typ publikacji :
Journal Article
MeSH Terms :
Castration/*adverse effects
Endothelium, Vascular/*enzymology
Iliac Artery/*enzymology
Nitric Oxide Synthase Type III/*metabolism
Penis/*blood supply
Proto-Oncogene Proteins c-akt/*metabolism
Testosterone/*deficiency
Vasodilation/*physiology
Animals ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/physiopathology ; Iliac Artery/drug effects ; Iliac Artery/physiopathology ; Male ; Models, Animal ; Penile Erection/drug effects ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Rats ; Rats, Sprague-Dawley ; Vasodilation/drug effects
Czasopismo naukowe
Tytuł :
GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism.
Autorzy :
Rochette L; Pathophysiology and Epidemiology of Cerebro-Cardiovascular Diseases Research Unit (PEC2, EA 7460), University of Burgundy and Franche-Comté, UFR des Sciences de Santé, 21079 Dijon, France. Electronic address: .
Zeller M; Pathophysiology and Epidemiology of Cerebro-Cardiovascular Diseases Research Unit (PEC2, EA 7460), University of Burgundy and Franche-Comté, UFR des Sciences de Santé, 21079 Dijon, France.
Cottin Y; Cardiology Unit, Dijon Bourgogne University Hospital, 21000 Dijon, France.
Vergely C; Pathophysiology and Epidemiology of Cerebro-Cardiovascular Diseases Research Unit (PEC2, EA 7460), University of Burgundy and Franche-Comté, UFR des Sciences de Santé, 21079 Dijon, France.
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Źródło :
Trends in endocrinology and metabolism: TEM [Trends Endocrinol Metab] 2021 Nov; Vol. 32 (11), pp. 875-889. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
COVID-19/*immunology
Cytokine Release Syndrome/*immunology
Endothelium, Vascular/*immunology
Growth Differentiation Factor 15/*immunology
Iron/*metabolism
Apoptosis/immunology ; COVID-19/drug therapy ; COVID-19/metabolism ; Cytokine Release Syndrome/metabolism ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/physiopathology ; Glial Cell Line-Derived Neurotrophic Factor Receptors/immunology ; Glial Cell Line-Derived Neurotrophic Factor Receptors/metabolism ; Growth Differentiation Factor 15/metabolism ; Humans ; Immunologic Factors/therapeutic use ; Oxidative Stress/immunology ; Prognosis ; Pyroptosis/immunology ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Interleukin-35 inhibits lipopolysaccharide-induced endothelial cell activation by downregulating inflammation and apoptosis.
Autorzy :
Li M; Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China. Electronic address: .
Liu Y; Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China. Electronic address: .
Fu Y; Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China. Electronic address: .
Gong R; Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China. Electronic address: .
Xia H; Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China. Electronic address: .
Huang X; Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China. Electronic address: .
Wu Y; Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2021 Oct 15; Vol. 407 (2), pp. 112784. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Anti-Inflammatory Agents/*pharmacology
Endothelium, Vascular/*metabolism
Inflammation/*prevention & control
Interleukins/*metabolism
Lipopolysaccharides/*toxicity
Sepsis/*prevention & control
Animals ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/pathology ; Gene Expression Regulation ; Humans ; Inflammation/chemically induced ; Inflammation/metabolism ; Inflammation/pathology ; Interleukins/administration & dosage ; Interleukins/genetics ; Male ; Mice ; Mice, Inbred C57BL ; NF-kappa B/genetics ; NF-kappa B/metabolism ; STAT1 Transcription Factor/genetics ; STAT1 Transcription Factor/metabolism ; STAT4 Transcription Factor/genetics ; STAT4 Transcription Factor/metabolism ; Sepsis/chemically induced ; Sepsis/metabolism ; Sepsis/pathology ; Signal Transduction
Czasopismo naukowe
Tytuł :
TRIM46 contributes to high glucose-induced ferroptosis and cell growth inhibition in human retinal capillary endothelial cells by facilitating GPX4 ubiquitination.
Autorzy :
Zhang J; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.
Qiu Q; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.
Wang H; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.
Chen C; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.
Luo D; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2021 Oct 15; Vol. 407 (2), pp. 112800. Date of Electronic Publication: 2021 Sep 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ferroptosis*
Ubiquitination*
Endothelium, Vascular/*pathology
Glucose/*adverse effects
Growth Inhibitors/*adverse effects
Phospholipid Hydroperoxide Glutathione Peroxidase/*metabolism
Retina/*pathology
Tripartite Motif Proteins/*metabolism
Cell Death ; Cell Proliferation ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Humans ; Phospholipid Hydroperoxide Glutathione Peroxidase/genetics ; Reactive Oxygen Species ; Retina/drug effects ; Retina/metabolism ; Sweetening Agents/adverse effects
Czasopismo naukowe
Tytuł :
Role of Human Primary Renal Fibroblast in TGF-β1-Mediated Fibrosis-Mimicking Devices.
Autorzy :
Hwang SH; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si 13620, Korea.
Lee YM; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si 13620, Korea.
Choi Y; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si 13620, Korea.
Son HE; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si 13620, Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.
Ryu JY; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si 13620, Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.
Na KY; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si 13620, Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.
Chin HJ; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si 13620, Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.
Jeon NL; Program for Bioengineering, School of Engineering, Seoul National University, Seoul 08826, Korea.
Kim S; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si 13620, Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 05; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 05.
Typ publikacji :
Journal Article
MeSH Terms :
Endothelium, Vascular/*pathology
Fibroblasts/*pathology
Fibrosis/*pathology
Kidney Tubules, Proximal/*pathology
Printing, Three-Dimensional/*instrumentation
Transforming Growth Factor beta1/*pharmacology
Cells, Cultured ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibrosis/chemically induced ; Fibrosis/metabolism ; Humans ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/metabolism
Czasopismo naukowe
Tytuł :
Natural Anti-Endothelial Cell Antibodies in Patients Undergoing Coronary Angiography.
Autorzy :
Teodorovich N; Kaplan Heart Center, Kaplan Medical Center, Rehovot, affiliated with Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Jonas M; Kaplan Heart Center, Kaplan Medical Center, Rehovot, affiliated with Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Haberman D; Kaplan Heart Center, Kaplan Medical Center, Rehovot, affiliated with Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Abu Khadija H; Kaplan Heart Center, Kaplan Medical Center, Rehovot, affiliated with Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Ayyad O; Kaplan Heart Center, Kaplan Medical Center, Rehovot, affiliated with Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Gandelman G; Kaplan Heart Center, Kaplan Medical Center, Rehovot, affiliated with Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Poles L; Kaplan Heart Center, Kaplan Medical Center, Rehovot, affiliated with Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Israel.
George J; Kaplan Heart Center, Kaplan Medical Center, Rehovot, affiliated with Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Blatt A; Kaplan Heart Center, Kaplan Medical Center, Rehovot, affiliated with Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Israel.
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Źródło :
The Israel Medical Association journal : IMAJ [Isr Med Assoc J] 2021 Oct; Vol. 23 (10), pp. 657-661.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Coronary Angiography*/methods
Coronary Angiography*/statistics & numerical data
Coronary Artery Disease*/diagnosis
Coronary Artery Disease*/immunology
Coronary Artery Disease*/mortality
Endothelium, Vascular*/immunology
Endothelium, Vascular*/physiopathology
Autoantibodies/*blood
Aged ; Biomarkers/blood ; Female ; Follow-Up Studies ; Humans ; Immunologic Tests/methods ; Israel/epidemiology ; Male ; Prognosis ; Protective Factors ; Reproducibility of Results ; Risk Assessment/methods
Czasopismo naukowe
Tytuł :
Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19: Current Findings and Therapeutic Implications.
Autorzy :
Higashikuni Y; Department of Cardiovascular Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Liu W; Department of Cardiovascular Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Obana T; Department of Cardiovascular Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Sata M; Department of Cardiovascular Medicine, The University of Tokushima, Tokushima 770-8503, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 08; Vol. 22 (21). Date of Electronic Publication: 2021 Nov 08.
Typ publikacji :
Journal Article; Review
MeSH Terms :
COVID-19/*pathology
Endothelium, Vascular/*physiopathology
Thrombosis/*etiology
Angiotensin-Converting Enzyme 2/metabolism ; Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; Blood Coagulation ; COVID-19/complications ; COVID-19/drug therapy ; COVID-19/virology ; Endothelium, Vascular/metabolism ; Humans ; Immunity, Innate ; Platelet Activation ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/physiology
Czasopismo naukowe
Tytuł :
Biomarkers of endothelial dysfunction and outcomes in coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis.
Autorzy :
Andrianto; Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya 60286, Indonesia. Electronic address: .
Al-Farabi MJ; Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya 60286, Indonesia. Electronic address: .
Nugraha RA; Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya 60286, Indonesia. Electronic address: .
Marsudi BA; Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Azmi Y; Faculty of Medicine, Universitas Airlangga, Surabaya 60286, Indonesia. Electronic address: .
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Źródło :
Microvascular research [Microvasc Res] 2021 Nov; Vol. 138, pp. 104224. Date of Electronic Publication: 2021 Jul 15.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
COVID-19/*blood
Endothelium, Vascular/*metabolism
Plasminogen Activator Inhibitor 1/*blood
Thrombomodulin/*blood
Tissue Plasminogen Activator/*blood
von Willebrand Factor/*analysis
Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; COVID-19/diagnosis ; COVID-19/physiopathology ; COVID-19/therapy ; Endothelium, Vascular/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis
Czasopismo naukowe
Tytuł :
Metformin Prevents Hyperglycemia-Associated, Oxidative Stress-Induced Vascular Endothelial Dysfunction: Essential Role for the Orphan Nuclear Receptor Human Nuclear Receptor 4A1 (Nur77).
Autorzy :
Venu VKP; Inflammation Research Network and Snyder Institute for Chronic Diseases, Department of Physiology & Pharmacology (V.K.P.V, M.S., K.M., M.M., S.A.H., M.D.H.), and Department of Medicine (M.D.H.), University of Calgary Cumming School of Medicine, Calgary AB, Canada; Alberta Children's Hospital Research Institute and Department of Chemistry, University of Calgary AB, Canada (E.G., A.J.F., D.D.); Departments of Pharmacology and Medical Education, Weill Cornell Medicine in Qatar, Al-Rayyan, Doha, Qatar (I. M., D. A-M., H.D., C.R.T.) and Bioinformatics (M.F.), Jamia Millia Islamia (Central University), Jaima Nagar, Okhla New Delhi, India .
Saifeddine M; Inflammation Research Network and Snyder Institute for Chronic Diseases, Department of Physiology & Pharmacology (V.K.P.V, M.S., K.M., M.M., S.A.H., M.D.H.), and Department of Medicine (M.D.H.), University of Calgary Cumming School of Medicine, Calgary AB, Canada; Alberta Children's Hospital Research Institute and Department of Chemistry, University of Calgary AB, Canada (E.G., A.J.F., D.D.); Departments of Pharmacology and Medical Education, Weill Cornell Medicine in Qatar, Al-Rayyan, Doha, Qatar (I. M., D. A-M., H.D., C.R.T.) and Bioinformatics (M.F.), Jamia Millia Islamia (Central University), Jaima Nagar, Okhla New Delhi, India.
Mihara K; Inflammation Research Network and Snyder Institute for Chronic Diseases, Department of Physiology & Pharmacology (V.K.P.V, M.S., K.M., M.M., S.A.H., M.D.H.), and Department of Medicine (M.D.H.), University of Calgary Cumming School of Medicine, Calgary AB, Canada; Alberta Children's Hospital Research Institute and Department of Chemistry, University of Calgary AB, Canada (E.G., A.J.F., D.D.); Departments of Pharmacology and Medical Education, Weill Cornell Medicine in Qatar, Al-Rayyan, Doha, Qatar (I. M., D. A-M., H.D., C.R.T.) and Bioinformatics (M.F.), Jamia Millia Islamia (Central University), Jaima Nagar, Okhla New Delhi, India.
Faiza M; Inflammation Research Network and Snyder Institute for Chronic Diseases, Department of Physiology & Pharmacology (V.K.P.V, M.S., K.M., M.M., S.A.H., M.D.H.), and Department of Medicine (M.D.H.), University of Calgary Cumming School of Medicine, Calgary AB, Canada; Alberta Children's Hospital Research Institute and Department of Chemistry, University of Calgary AB, Canada (E.G., A.J.F., D.D.); Departments of Pharmacology and Medical Education, Weill Cornell Medicine in Qatar, Al-Rayyan, Doha, Qatar (I. M., D. A-M., H.D., C.R.T.) and Bioinformatics (M.F.), Jamia Millia Islamia (Central University), Jaima Nagar, Okhla New Delhi, India.
Gorobets E; Inflammation Research Network and Snyder Institute for Chronic Diseases, Department of Physiology & Pharmacology (V.K.P.V, M.S., K.M., M.M., S.A.H., M.D.H.), and Department of Medicine (M.D.H.), University of Calgary Cumming School of Medicine, Calgary AB, Canada; Alberta Children's Hospital Research Institute and Department of Chemistry, University of Calgary AB, Canada (E.G., A.J.F., D.D.); Departments of Pharmacology and Medical Education, Weill Cornell Medicine in Qatar, Al-Rayyan, Doha, Qatar (I. M., D. A-M., H.D., C.R.T.) and Bioinformatics (M.F.), Jamia Millia Islamia (Central University), Jaima Nagar, Okhla New Delhi, India.
Flewelling AJ; Inflammation Research Network and Snyder Institute for Chronic Diseases, Department of Physiology & Pharmacology (V.K.P.V, M.S., K.M., M.M., S.A.H., M.D.H.), and Department of Medicine (M.D.H.), University of Calgary Cumming School of Medicine, Calgary AB, Canada; Alberta Children's Hospital Research Institute and Department of Chemistry, University of Calgary AB, Canada (E.G., A.J.F., D.D.); Departments of Pharmacology and Medical Education, Weill Cornell Medicine in Qatar, Al-Rayyan, Doha, Qatar (I. M., D. A-M., H.D., C.R.T.) and Bioinformatics (M.F.), Jamia Millia Islamia (Central University), Jaima Nagar, Okhla New Delhi, India.
Derksen DJ; Inflammation Research Network and Snyder Institute for Chronic Diseases, Department of Physiology & Pharmacology (V.K.P.V, M.S., K.M., M.M., S.A.H., M.D.H.), and Department of Medicine (M.D.H.), University of Calgary Cumming School of Medicine, Calgary AB, Canada; Alberta Children's Hospital Research Institute and Department of Chemistry, University of Calgary AB, Canada (E.G., A.J.F., D.D.); Departments of Pharmacology and Medical Education, Weill Cornell Medicine in Qatar, Al-Rayyan, Doha, Qatar (I. M., D. A-M., H.D., C.R.T.) and Bioinformatics (M.F.), Jamia Millia Islamia (Central University), Jaima Nagar, Okhla New Delhi, India.
Hirota SA; Inflammation Research Network and Snyder Institute for Chronic Diseases, Department of Physiology & Pharmacology (V.K.P.V, M.S., K.M., M.M., S.A.H., M.D.H.), and Department of Medicine (M.D.H.), University of Calgary Cumming School of Medicine, Calgary AB, Canada; Alberta Children's Hospital Research Institute and Department of Chemistry, University of Calgary AB, Canada (E.G., A.J.F., D.D.); Departments of Pharmacology and Medical Education, Weill Cornell Medicine in Qatar, Al-Rayyan, Doha, Qatar (I. M., D. A-M., H.D., C.R.T.) and Bioinformatics (M.F.), Jamia Millia Islamia (Central University), Jaima Nagar, Okhla New Delhi, India.
Marei I; Inflammation Research Network and Snyder Institute for Chronic Diseases, Department of Physiology & Pharmacology (V.K.P.V, M.S., K.M., M.M., S.A.H., M.D.H.), and Department of Medicine (M.D.H.), University of Calgary Cumming School of Medicine, Calgary AB, Canada; Alberta Children's Hospital Research Institute and Department of Chemistry, University of Calgary AB, Canada (E.G., A.J.F., D.D.); Departments of Pharmacology and Medical Education, Weill Cornell Medicine in Qatar, Al-Rayyan, Doha, Qatar (I. M., D. A-M., H.D., C.R.T.) and Bioinformatics (M.F.), Jamia Millia Islamia (Central University), Jaima Nagar, Okhla New Delhi, India.
Al-Majid D; Inflammation Research Network and Snyder Institute for Chronic Diseases, Department of Physiology & Pharmacology (V.K.P.V, M.S., K.M., M.M., S.A.H., M.D.H.), and Department of Medicine (M.D.H.), University of Calgary Cumming School of Medicine, Calgary AB, Canada; Alberta Children's Hospital Research Institute and Department of Chemistry, University of Calgary AB, Canada (E.G., A.J.F., D.D.); Departments of Pharmacology and Medical Education, Weill Cornell Medicine in Qatar, Al-Rayyan, Doha, Qatar (I. M., D. A-M., H.D., C.R.T.) and Bioinformatics (M.F.), Jamia Millia Islamia (Central University), Jaima Nagar, Okhla New Delhi, India.
Motahhary M; Inflammation Research Network and Snyder Institute for Chronic Diseases, Department of Physiology & Pharmacology (V.K.P.V, M.S., K.M., M.M., S.A.H., M.D.H.), and Department of Medicine (M.D.H.), University of Calgary Cumming School of Medicine, Calgary AB, Canada; Alberta Children's Hospital Research Institute and Department of Chemistry, University of Calgary AB, Canada (E.G., A.J.F., D.D.); Departments of Pharmacology and Medical Education, Weill Cornell Medicine in Qatar, Al-Rayyan, Doha, Qatar (I. M., D. A-M., H.D., C.R.T.) and Bioinformatics (M.F.), Jamia Millia Islamia (Central University), Jaima Nagar, Okhla New Delhi, India.
Ding H; Inflammation Research Network and Snyder Institute for Chronic Diseases, Department of Physiology & Pharmacology (V.K.P.V, M.S., K.M., M.M., S.A.H., M.D.H.), and Department of Medicine (M.D.H.), University of Calgary Cumming School of Medicine, Calgary AB, Canada; Alberta Children's Hospital Research Institute and Department of Chemistry, University of Calgary AB, Canada (E.G., A.J.F., D.D.); Departments of Pharmacology and Medical Education, Weill Cornell Medicine in Qatar, Al-Rayyan, Doha, Qatar (I. M., D. A-M., H.D., C.R.T.) and Bioinformatics (M.F.), Jamia Millia Islamia (Central University), Jaima Nagar, Okhla New Delhi, India.
Triggle CR; Inflammation Research Network and Snyder Institute for Chronic Diseases, Department of Physiology & Pharmacology (V.K.P.V, M.S., K.M., M.M., S.A.H., M.D.H.), and Department of Medicine (M.D.H.), University of Calgary Cumming School of Medicine, Calgary AB, Canada; Alberta Children's Hospital Research Institute and Department of Chemistry, University of Calgary AB, Canada (E.G., A.J.F., D.D.); Departments of Pharmacology and Medical Education, Weill Cornell Medicine in Qatar, Al-Rayyan, Doha, Qatar (I. M., D. A-M., H.D., C.R.T.) and Bioinformatics (M.F.), Jamia Millia Islamia (Central University), Jaima Nagar, Okhla New Delhi, India.
Hollenberg MD; Inflammation Research Network and Snyder Institute for Chronic Diseases, Department of Physiology & Pharmacology (V.K.P.V, M.S., K.M., M.M., S.A.H., M.D.H.), and Department of Medicine (M.D.H.), University of Calgary Cumming School of Medicine, Calgary AB, Canada; Alberta Children's Hospital Research Institute and Department of Chemistry, University of Calgary AB, Canada (E.G., A.J.F., D.D.); Departments of Pharmacology and Medical Education, Weill Cornell Medicine in Qatar, Al-Rayyan, Doha, Qatar (I. M., D. A-M., H.D., C.R.T.) and Bioinformatics (M.F.), Jamia Millia Islamia (Central University), Jaima Nagar, Okhla New Delhi, India .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2021 Nov; Vol. 100 (5), pp. 428-455. Date of Electronic Publication: 2021 Aug 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelium, Vascular/*drug effects
Hyperglycemia/*prevention & control
Hypoglycemic Agents/*therapeutic use
Metformin/*therapeutic use
Nuclear Receptor Subfamily 4, Group A, Member 1/*biosynthesis
Oxidative Stress/*drug effects
Animals ; Cells, Cultured ; Dose-Response Relationship, Drug ; Endothelium, Vascular/metabolism ; HEK293 Cells ; Humans ; Hyperglycemia/metabolism ; Hypoglycemic Agents/pharmacology ; Male ; Metformin/pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Organ Culture Techniques ; Oxidative Stress/physiology ; Vasodilator Agents/pharmacology
Czasopismo naukowe
Tytuł :
Effect of hydroxyurea therapy on intravascular hemolysis and endothelial dysfunction markers in sickle cell anemia patients.
Autorzy :
Chenou F; Department of Clinical Pathology, School of Medical Sciences, State University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
Hounkpe BW; Hematology and Hemotherapy Center, State University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
Domingos IF; Department of Clinical and Toxicological Analysis, Federal University of Rio Grande Do Norte, Natal, RN, Brazil.
Tonassé WV; Department of Clinical Pathology, School of Medical Sciences, State University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
Batista THC; Genetics Postgraduate Program, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil.
Santana RM; Genetics Postgraduate Program, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil.
Arcanjo GDS; Genetics Postgraduate Program, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil.
Alagbe AE; Department of Clinical Pathology, School of Medical Sciences, State University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
Araújo ADS; Hematology and Hemotherapy Foundation of Pernambuco (HEMOPE), Pernambuco, Recife, Brazil.
Lucena-Araújo AR; Genetics Postgraduate Program, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil.
Bezerra MAC; Genetics Postgraduate Program, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil.
Costa FF; Hematology and Hemotherapy Center, State University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
Sonati MF; Department of Clinical Pathology, School of Medical Sciences, State University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
De Paula EV; Hematology and Hemotherapy Center, State University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
Dos Santos MNN; Department of Clinical Pathology, School of Medical Sciences, State University of Campinas-UNICAMP, Campinas, São Paulo, Brazil. .
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Źródło :
Annals of hematology [Ann Hematol] 2021 Nov; Vol. 100 (11), pp. 2669-2676. Date of Electronic Publication: 2021 Aug 28.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Anemia, Sickle Cell/*drug therapy
Endothelium, Vascular/*physiopathology
Hemolysis/*drug effects
Hydroxyurea/*therapeutic use
ADAMTS13 Protein/blood ; Adolescent ; Adult ; Anemia, Sickle Cell/blood ; Antigens, CD/blood ; Antigens, Differentiation, Myelomonocytic/blood ; Biomarkers ; Cross-Sectional Studies ; Endothelium, Vascular/drug effects ; Female ; Heme/analysis ; Hemoglobins/analysis ; Humans ; Hydroxyurea/pharmacology ; L-Lactate Dehydrogenase/blood ; Male ; Middle Aged ; Receptors, Cell Surface/blood ; Thrombospondin 1/blood ; Young Adult ; von Willebrand Factor/analysis
Czasopismo naukowe
Tytuł :
There are no differences in brachial artery endothelial shear stress and blood flow patterns between males and females during exercise.
Autorzy :
Gurovich AN; Clinical Applied Physiology (CAPh) Laboratory, College of Health Sciences, The University of Texas at El Paso, El Paso, TX, USA.; Doctor of Physical Therapy Program, College of Health Sciences, The University of Texas at El Paso, El Paso, TX, USA.
Rodriguez L; Clinical Applied Physiology (CAPh) Laboratory, College of Health Sciences, The University of Texas at El Paso, El Paso, TX, USA.
Morales-Acuna F; Clinical Applied Physiology (CAPh) Laboratory, College of Health Sciences, The University of Texas at El Paso, El Paso, TX, USA.
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Źródło :
Clinical physiology and functional imaging [Clin Physiol Funct Imaging] 2021 Nov; Vol. 41 (6), pp. 471-479. Date of Electronic Publication: 2021 Jul 26.
Typ publikacji :
Journal Article
MeSH Terms :
Brachial Artery*/diagnostic imaging
Endothelium, Vascular*
Cross-Sectional Studies ; Exercise ; Female ; Hemodynamics ; Humans ; Male ; Regional Blood Flow ; Vasodilation
Czasopismo naukowe
Tytuł :
The endothelium is a key player in the vascular response to acute mental stress.
Autorzy :
Sara JDS; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Lerman LO; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Lerman A; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
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Źródło :
European heart journal [Eur Heart J] 2021 Oct 14; Vol. 42 (39), pp. 4089-4091.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Endothelium, Vascular*
Stress, Psychological*
Humans
Opinia redakcyjna
Tytuł :
Empagliflozin Relaxes Resistance Mesenteric Arteries by Stimulating Multiple Smooth Muscle Cell Voltage-Gated K (K V ) Channels.
Autorzy :
Hasan A; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, 3001 Mercer University Drive, Atlanta, GA 30341, USA.
Hasan R; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, 3001 Mercer University Drive, Atlanta, GA 30341, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 07; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 07.
Typ publikacji :
Journal Article
MeSH Terms :
Vasodilation*
Benzhydryl Compounds/*pharmacology
Endothelium, Vascular/*physiology
Glucosides/*pharmacology
Mesenteric Arteries/*physiology
Muscle, Smooth, Vascular/*physiology
Potassium Channels, Voltage-Gated/*metabolism
Vasodilator Agents/*pharmacology
Animals ; Endothelium, Vascular/drug effects ; Male ; Mesenteric Arteries/drug effects ; Muscle, Smooth, Vascular/drug effects ; Rats ; Rats, Sprague-Dawley ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
The Role of GPR15 Function in Blood and Vasculature.
Autorzy :
Bauer M; Department of Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, 04318 Leipzig, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 06; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cytoprotection*
Neovascularization, Physiologic*
Endothelium, Vascular/*physiology
Receptors, G-Protein-Coupled/*metabolism
Receptors, Peptide/*metabolism
Endothelium, Vascular/cytology ; Humans
Czasopismo naukowe
Tytuł :
How big is the endothelium? Comment on "Spatial and temporal dynamics of the endothelium".
Autorzy :
Rajala R; Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
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Źródło :
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2021 Oct; Vol. 19 (10), pp. 2634-2635.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelium, Vascular*
Humans
Raport
Tytuł :
Activation of AMP kinase ameliorates kidney vascular dysfunction, oxidative stress and inflammation in rodent models of obesity.
Autorzy :
Rodríguez C; Departamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Sánchez A; Departamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Sáenz-Medina J; Departamento de Urología, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
Muñoz M; Departamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Hernández M; Departamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
López M; NeurObesity Group, Department of Physiology, CIMUS, Universidad de Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.
Rivera L; Departamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Contreras C; Departamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Prieto D; Departamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2021 Oct; Vol. 178 (20), pp. 4085-4103. Date of Electronic Publication: 2021 Jul 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenylate Kinase*/metabolism
Endothelium, Vascular*/metabolism
AMP-Activated Protein Kinases/metabolism ; Animals ; Inflammation/metabolism ; Kidney/metabolism ; Mice ; Obesity/metabolism ; Oxidative Stress ; Phosphatidylinositol 3-Kinases/metabolism ; Rats ; Rats, Zucker ; Renal Artery ; Rodentia/metabolism ; Vasodilation
Czasopismo naukowe
Tytuł :
LncRNA SNHG12 alleviates hypertensive vascular endothelial injury through miR-25-3p/SIRT6 pathway.
Autorzy :
Qian W; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Zheng ZQ; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Nie JG; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Liu LJ; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Meng XZ; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Sun H; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Xiao FM; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Kang T; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Oct; Vol. 110 (4), pp. 651-661. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelium, Vascular/*injuries
Human Umbilical Vein Endothelial Cells/*metabolism
Hypertension/*genetics
MicroRNAs/*metabolism
RNA, Long Noncoding/*metabolism
Sirtuins/*metabolism
Angiotensin II ; Animals ; Base Sequence ; Down-Regulation/genetics ; Endothelium, Vascular/pathology ; Gene Expression Regulation ; Humans ; Male ; Mice, Inbred C57BL ; MicroRNAs/genetics ; RNA, Long Noncoding/genetics ; Signal Transduction ; Sirtuins/genetics
Czasopismo naukowe
Tytuł :
A Randomized, Multicenter, Open-Label, Blinded End Point, Phase 2, Feasibility, Efficacy, and Safety Trial of Preoperative Microvascular Protection in Patients Undergoing Major Abdominal Surgery.
Autorzy :
Yanase F; From the Department of Intensive Care, Austin Hospital, Melbourne, Australia.; Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Tosif SH; Department of Anaesthesia, Austin Hospital, Melbourne, Australia.
Churilov L; Department of Medicine (Austin Health) & Melbourne Brain Centre at Royal Melbourne Hospital, Melbourne Medical School Faculty of Medicine, The University of Melbourne, Melbourne, Australia.
Yee K; Department of Anaesthesia, Auckland City Hospital, Auckland, New Zealand.
Bellomo R; From the Department of Intensive Care, Austin Hospital, Melbourne, Australia.; Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Gunn K; Department of Anaesthesia, Auckland City Hospital, Auckland, New Zealand.
Kim C; Department of Anaesthesia, Auckland City Hospital, Auckland, New Zealand.
Krizhanovskii C; Department of Research, Södertälje Hospital, Södertälje, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institute, Solna, Sweden.
Hahn RG; Karolinska Institute at Danderyd's Hospital (KIDS), Stockholm, Sweden.
Riedel B; Department of Anaesthesia, Perioperative and Pain Medicine, Peter MacCallum Cancer Centre; and the Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.
Weinberg L; Department of Critical Care, University of Melbourne, Melbourne, Australia.
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Źródło :
Anesthesia and analgesia [Anesth Analg] 2021 Oct 01; Vol. 133 (4), pp. 1036-1047.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Digestive System Surgical Procedures*/adverse effects
Abdomen/*surgery
Albumins/*administration & dosage
Crystalloid Solutions/*administration & dosage
Dexamethasone/*administration & dosage
Endothelium, Vascular/*drug effects
Glucocorticoids/*administration & dosage
Microvessels/*drug effects
Postoperative Complications/*prevention & control
Aged ; Albumins/adverse effects ; Biomarkers/blood ; C-Reactive Protein/metabolism ; Crystalloid Solutions/adverse effects ; Dexamethasone/adverse effects ; Endothelium, Vascular/metabolism ; Feasibility Studies ; Female ; Glucocorticoids/adverse effects ; Glycocalyx/drug effects ; Glycocalyx/metabolism ; Heparitin Sulfate/blood ; Humans ; Infusions, Intravenous ; Male ; Microvessels/metabolism ; Middle Aged ; New Zealand ; Postoperative Complications/blood ; Postoperative Complications/etiology ; Preoperative Care ; Syndecan-1/blood ; Time Factors ; Treatment Outcome ; Victoria
Czasopismo naukowe
Tytuł :
Differential Effects of Ruminant and Industrial 18-Carbon trans -Monounsaturated Fatty Acids ( trans Vaccenic and Elaidic) on the Inflammatory Responses of an Endothelial Cell Line.
Autorzy :
Valenzuela CA; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.; School of Nutrition, Faculty of Pharmacy, University of Valparaíso, Playa Ancha, Valparaíso 2360102, Chile.
Baker EJ; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
De Souza CO; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.; Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo CEP 05508-000, SP, Brazil.
Miles EA; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
Calder PC; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton SO16 6YD, UK.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Sep 26; Vol. 26 (19). Date of Electronic Publication: 2021 Sep 26.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Carbon Radioisotopes/*analysis
Endothelium, Vascular/*immunology
Inflammation/*immunology
Oleic Acids/*pharmacology
Ruminants/*metabolism
Trans Fatty Acids/*pharmacology
Animals ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Humans ; Inflammation/drug therapy ; Inflammation/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Further Findings Concerning Endothelial Damage in COVID-19 Patients.
Autorzy :
Gelzo M; CEINGE-Biotecnologie Avanzate, scarl, 80145 Naples, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Naples, Italy.
Cacciapuoti S; Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, 80131 Naples, Italy.
Pinchera B; Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, 80131 Naples, Italy.
De Rosa A; Dipartimento di Malattie Infettive e Emergenze Infettive, Divisione di Malattie Infettive Respiratorie, Ospedale Cotugno, AORN dei Colli, 80131 Naples, Italy.
Cernera G; CEINGE-Biotecnologie Avanzate, scarl, 80145 Naples, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Naples, Italy.
Scialò F; CEINGE-Biotecnologie Avanzate, scarl, 80145 Naples, Italy.; Dipartimento di Medicina Traslazionale, Università della Campania L. Vanvitelli, 80131 Naples, Italy.
Comegna M; CEINGE-Biotecnologie Avanzate, scarl, 80145 Naples, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Naples, Italy.
Mormile M; Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, 80131 Naples, Italy.
Fabbrocini G; Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, 80131 Naples, Italy.
Parrella R; Dipartimento di Malattie Infettive e Emergenze Infettive, Divisione di Malattie Infettive Respiratorie, Ospedale Cotugno, AORN dei Colli, 80131 Naples, Italy.
Corso G; CEINGE-Biotecnologie Avanzate, scarl, 80145 Naples, Italy.; Dipartimento di Medicina Clinica e Sperimentale, Università di Foggia, 71121 Foggia, Italy.
Gentile I; Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, 80131 Naples, Italy.
Castaldo G; CEINGE-Biotecnologie Avanzate, scarl, 80145 Naples, Italy.; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Naples, Italy.
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Źródło :
Biomolecules [Biomolecules] 2021 Sep 16; Vol. 11 (9). Date of Electronic Publication: 2021 Sep 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19*/blood
COVID-19*/pathology
Endothelium, Vascular*/injuries
Endothelium, Vascular*/metabolism
Endothelium, Vascular*/pathology
Chemokine CCL8/*blood
E-Selectin/*blood
P-Selectin/*blood
SARS-CoV-2/*metabolism
Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Monocytes/metabolism ; Monocytes/pathology
Czasopismo naukowe

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