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Tytuł :
Immunostimulatory effects on THP-1 cells by peptide or protein pharmaceuticals associated with injection site reactions.
Autorzy :
Hamamura-Yasuno E; Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Aida T; Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc., Basking Ridge, NJ, USA.
Tsuchiya Y; Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Mori K; Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
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Źródło :
Journal of immunotoxicology [J Immunotoxicol] 2020 Dec; Vol. 17 (1), pp. 59-66.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal, Humanized/*immunology
Antigen-Presenting Cells/*immunology
Enfuvirtide/*immunology
Glatiramer Acetate/*immunology
Injection Site Reaction/*immunology
Antibodies, Monoclonal, Humanized/administration & dosage ; Antigen Presentation/drug effects ; Antigen-Presenting Cells/drug effects ; Antigen-Presenting Cells/metabolism ; Cytokines/metabolism ; Drug Evaluation, Preclinical/methods ; Enfuvirtide/administration & dosage ; Glatiramer Acetate/administration & dosage ; Humans ; Injections, Subcutaneous/adverse effects ; THP-1 Cells
Czasopismo naukowe
Tytuł :
The Tryptophan-Rich Motif of HIV-1 gp41 Can Interact with the N-Terminal Deep Pocket Site: New Insights into the Structure and Function of gp41 and Its Inhibitors.
Autorzy :
Zhu Y; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Ding X; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yu D; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chong H; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
He Y; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China .; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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Źródło :
Journal of virology [J Virol] 2019 Dec 12; Vol. 94 (1). Date of Electronic Publication: 2019 Dec 12 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enfuvirtide/*metabolism
HIV Envelope Protein gp41/*chemistry
HIV Fusion Inhibitors/*metabolism
HIV-1/*chemistry
Tryptophan/*chemistry
Amino Acid Motifs ; Binding Sites ; Circular Dichroism ; Enfuvirtide/chemical synthesis ; HEK293 Cells ; HIV Envelope Protein gp41/antagonists & inhibitors ; HIV Envelope Protein gp41/metabolism ; HIV Fusion Inhibitors/chemical synthesis ; HIV-1/metabolism ; Humans ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Structure, Secondary ; Structure-Activity Relationship ; Tryptophan/metabolism
Czasopismo naukowe
Tytuł :
HIVfird: A Tool for Detection of Resistance to Fusion Inhibitor Drugs in HIV-1 Sequences.
Autorzy :
Barreto Vasconcelos AL; Department of Biochemistry and Biophysics, Federal University of Bahia, Salvador, Brazil.
Monteiro-Cunha JP; Department of Biochemistry and Biophysics, Federal University of Bahia, Salvador, Brazil.
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Źródło :
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2019 Oct; Vol. 35 (10), pp. 941-947. Date of Electronic Publication: 2019 Aug 12.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Viral*/genetics
Mutation*
Software*
DNA Mutational Analysis/*methods
DNA, Viral/*genetics
Enfuvirtide/*pharmacokinetics
HIV Envelope Protein gp41/*genetics
HIV Fusion Inhibitors/*pharmacology
HIV Infections/*drug therapy
HIV-1/*drug effects
Amino Acid Sequence ; Amino Acid Substitution ; Base Sequence ; Databases, Genetic ; Enfuvirtide/therapeutic use ; Global Health ; HIV Envelope Protein gp41/physiology ; HIV Fusion Inhibitors/therapeutic use ; HIV Infections/virology ; HIV-1/classification ; HIV-1/genetics ; HIV-1/isolation & purification ; Humans ; Internet ; Mutation, Missense ; Sequence Alignment ; Sequence Homology, Nucleic Acid
Czasopismo naukowe
Tytuł :
Revisiting the mechanism of enfuvirtide and designing an analog with improved fusion inhibitory activity by targeting triple sites in gp41.
Autorzy :
Xu W; Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Pu J; Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Su S; Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Hua C; Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Su X; Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Wang Q; Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jiang S; Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.; Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA.
Lu L; Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
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Źródło :
AIDS (London, England) [AIDS] 2019 Aug 01; Vol. 33 (10), pp. 1545-1555.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery/*methods
Enfuvirtide/*chemistry
Enfuvirtide/*pharmacology
HIV Envelope Protein gp41/*chemistry
HIV Envelope Protein gp41/*metabolism
HIV Fusion Inhibitors/*chemistry
HIV Fusion Inhibitors/*pharmacology
Animals ; Binding Sites ; Cell Fusion ; Cell Line ; Enfuvirtide/chemical synthesis ; HIV Core Protein p24/metabolism ; HIV Fusion Inhibitors/chemical synthesis ; Humans ; Protein Binding ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Temperature
Czasopismo naukowe
Tytuł :
Optimization of peptidic HIV-1 fusion inhibitor T20 by phage display.
Autorzy :
Chen G; Banting and Best Department of Medical Research, The Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
Cook JD; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
Ye W; Banting and Best Department of Medical Research, The Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
Lee JE; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
Sidhu SS; Banting and Best Department of Medical Research, The Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, M5S 3E1, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
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Źródło :
Protein science : a publication of the Protein Society [Protein Sci] 2019 Aug; Vol. 28 (8), pp. 1501-1512.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Peptide Library*
Enfuvirtide/*pharmacology
HIV Envelope Protein gp41/*antagonists & inhibitors
HIV Fusion Inhibitors/*pharmacology
Enfuvirtide/chemistry ; HIV Envelope Protein gp41/chemistry ; HIV Envelope Protein gp41/metabolism ; HIV Fusion Inhibitors/chemistry ; Humans ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Protein Conformation
Czasopismo naukowe
Tytuł :
Metabolic, mitochondrial, renal and hepatic safety of enfuvirtide and raltegravir antiretroviral administration: Randomized crossover clinical trial in healthy volunteers.
Autorzy :
Barroso S; Muscle Research and Mitochondrial Function Laboratory, Cellex-IDIBAPS, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.; Internal Medicine Department-Hospital Clínic of Barcelona (HCB), Barcelona, Spain.; Biomedical Research Networking Centres of Rare Diseases CIBERER (ISCIII), Barcelona, Spain.; Pompeu Fabra University, Barcelona, Spain.; Autonomous University of Barcelona, Barcelona, Spain.
Morén C; Muscle Research and Mitochondrial Function Laboratory, Cellex-IDIBAPS, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.; Internal Medicine Department-Hospital Clínic of Barcelona (HCB), Barcelona, Spain.; Biomedical Research Networking Centres of Rare Diseases CIBERER (ISCIII), Barcelona, Spain.
González-Segura À; Muscle Research and Mitochondrial Function Laboratory, Cellex-IDIBAPS, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.; Internal Medicine Department-Hospital Clínic of Barcelona (HCB), Barcelona, Spain.; Biomedical Research Networking Centres of Rare Diseases CIBERER (ISCIII), Barcelona, Spain.
Riba N; Phase I Unit, Clinical Pharmacology Department, HCB, Barcelona, Spain.
Arnaiz JA; Phase I Unit, Clinical Pharmacology Department, HCB, Barcelona, Spain.
Manriquez M; Phase I Unit, Clinical Pharmacology Department, HCB, Barcelona, Spain.
Santana G; Phase I Unit, Clinical Pharmacology Department, HCB, Barcelona, Spain.
Blanco JL; Infectious Diseases Department, HCB, Barcelona, Spain.
Larousse M; Infectious Diseases Department, HCB, Barcelona, Spain.
Loncà M; Infectious Diseases Department, HCB, Barcelona, Spain.
Lazzari E; Department of Statistics, University of Barcelona, Barcelona, Spain.
Llopis J; Department of Statistics, University of Barcelona, Barcelona, Spain.
Mallolas J; Infectious Diseases Department, HCB, Barcelona, Spain.
Miró O; Emergency Department, HCB, Barcelona, Spain.
Carné X; Phase I Unit, Clinical Pharmacology Department, HCB, Barcelona, Spain.
Gatell JM; Infectious Diseases Department, HCB, Barcelona, Spain.
Garrabou G; Muscle Research and Mitochondrial Function Laboratory, Cellex-IDIBAPS, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.; Internal Medicine Department-Hospital Clínic of Barcelona (HCB), Barcelona, Spain.; Biomedical Research Networking Centres of Rare Diseases CIBERER (ISCIII), Barcelona, Spain.
Martínez E; Infectious Diseases Department, HCB, Barcelona, Spain.
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Źródło :
PloS one [PLoS One] 2019 May 23; Vol. 14 (5), pp. e0216712. Date of Electronic Publication: 2019 May 23 (Print Publication: 2019).
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Enfuvirtide/*pharmacology
Raltegravir Potassium/*pharmacology
Adult ; Alanine Transaminase/analysis ; Alanine Transaminase/blood ; Anti-Retroviral Agents/therapeutic use ; Creatine/analysis ; Creatine/blood ; Enfuvirtide/metabolism ; Enfuvirtide/toxicity ; HIV Infections/drug therapy ; Healthy Volunteers ; Humans ; Insulin Resistance ; Kidney/drug effects ; Leukocytes, Mononuclear/metabolism ; Lipids/analysis ; Liver/drug effects ; Male ; Metabolism/drug effects ; Mitochondria/drug effects ; Raltegravir Potassium/metabolism ; Raltegravir Potassium/toxicity
Czasopismo naukowe
Tytuł :
A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats.
Autorzy :
Kaminskas LM; School of Biomedical Sciences, University of Queensland, Brisbane, St Lucia, QLD 4072, Australia. Electronic address: .
Williams CC; CSIRO Materials Science and Engineering, 343 Royal Parade, Parkville, Victoria 3052, Australia.
Leong NJ; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Chan LJ; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Butcher NJ; School of Biomedical Sciences, University of Queensland, Brisbane, St Lucia, QLD 4072, Australia.
Feeney OM; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Porter CJH; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Tyssen D; Burnet Institute, 89 Commercial Rd, Melbourne, Victoria 3004, Australia; Department of Microbiology, Monash University, Clayton, Victoria 3168, Australia; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia; School of Science, College of Science, Engineering and Health, RMIT University, Melbourne, Victoria 3000, Australia.
Tachedjian G; Burnet Institute, 89 Commercial Rd, Melbourne, Victoria 3004, Australia; Department of Microbiology, Monash University, Clayton, Victoria 3168, Australia; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia; School of Science, College of Science, Engineering and Health, RMIT University, Melbourne, Victoria 3000, Australia.
Ascher DB; Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, 30 Flemington Road, Parkville 3052, Australia.
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Źródło :
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2019 Apr; Vol. 137, pp. 218-226. Date of Electronic Publication: 2019 Mar 06.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Enfuvirtide/*administration & dosage
HIV/*drug effects
HIV Fusion Inhibitors/*administration & dosage
Polyethylene Glycols/*chemistry
Animals ; Cell Line ; Enfuvirtide/pharmacokinetics ; Enfuvirtide/pharmacology ; Enzyme-Linked Immunosorbent Assay ; HIV Fusion Inhibitors/pharmacokinetics ; HIV Fusion Inhibitors/pharmacology ; HIV Infections/drug therapy ; Humans ; Lymph/metabolism ; Male ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Monotherapy with a low-dose lipopeptide HIV fusion inhibitor maintains long-term viral suppression in rhesus macaques.
Autorzy :
Chong H; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xue J; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
Zhu Y; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Cong Z; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
Chen T; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
Wei Q; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
Qin C; Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
He Y; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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Źródło :
PLoS pathogens [PLoS Pathog] 2019 Feb 04; Vol. 15 (2), pp. e1007552. Date of Electronic Publication: 2019 Feb 04 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enfuvirtide/*therapeutic use
Lipopeptides/*therapeutic use
Simian Acquired Immunodeficiency Syndrome/*therapy
Animals ; Anti-Retroviral Agents ; Antibodies, Neutralizing ; Drug Resistance, Viral ; Enfuvirtide/pharmacology ; HEK293 Cells ; HIV Fusion Inhibitors/pharmacology ; HIV Fusion Inhibitors/therapeutic use ; HIV Infections/therapy ; HIV-1/pathogenicity ; Humans ; Macaca mulatta/immunology ; Macaca mulatta/metabolism ; Male ; Rats ; Rats, Sprague-Dawley ; Simian Immunodeficiency Virus/pathogenicity ; Viral Load ; Virus Internalization
Czasopismo naukowe
Tytuł :
Exceptional potency and structural basis of a T1249-derived lipopeptide fusion inhibitor against HIV-1, HIV-2, and simian immunodeficiency virus.
Autorzy :
Zhu Y; From the MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.; the Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Zhang X; the College of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University, Beijing 100044, China, and.
Ding X; From the MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.; the Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Chong H; From the MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.; the Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Cui S; From the MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
He J; the College of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University, Beijing 100044, China, and.
Wang X; the Ministry of Education Key Laboratory of Protein Science, Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
He Y; From the MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China, .; the Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2018 Apr 06; Vol. 293 (14), pp. 5323-5334. Date of Electronic Publication: 2018 Feb 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enfuvirtide/*analogs & derivatives
Enfuvirtide/*chemistry
HIV Fusion Inhibitors/*chemistry
Amino Acid Sequence ; Anti-Retroviral Agents/pharmacology ; Crystallography, X-Ray/methods ; Drug Design ; Drug Resistance, Viral/drug effects ; Enfuvirtide/pharmacology ; HIV-1/metabolism ; HIV-1/physiology ; HIV-2/metabolism ; HIV-2/physiology ; Humans ; Lipopeptides/pharmacology ; Peptide Fragments/pharmacology ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
Enfuvirtide-Protoporphyrin IX Dual-Loaded Liposomes: In Vitro Evidence of Synergy against HIV-1 Entry into Cells.
Autorzy :
Figueira TN; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina , Universidade de Lisboa , 1649-028 Lisbon , Portugal.
Domingues MM; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina , Universidade de Lisboa , 1649-028 Lisbon , Portugal.
Illien F; Sorbonne Université , École Normale Supérieure, PSL University, CNRS, Laboratoire des Biomolécules, LBM , 75005 Paris , France.
Cadima-Couto I; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina , Universidade de Lisboa , 1649-028 Lisbon , Portugal.
Todorovski T; Department of Experimental and Health Science , Universitat Pompeu Fabra , Barcelona Biomedical Research Park , 08003 Barcelona , Spain.
Andreu D; Department of Experimental and Health Science , Universitat Pompeu Fabra , Barcelona Biomedical Research Park , 08003 Barcelona , Spain.
Sagan S; Sorbonne Université , École Normale Supérieure, PSL University, CNRS, Laboratoire des Biomolécules, LBM , 75005 Paris , France.
Castanho MARB; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina , Universidade de Lisboa , 1649-028 Lisbon , Portugal.
Walrant A; Sorbonne Université , École Normale Supérieure, PSL University, CNRS, Laboratoire des Biomolécules, LBM , 75005 Paris , France.
Veiga AS; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina , Universidade de Lisboa , 1649-028 Lisbon , Portugal.
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Źródło :
ACS infectious diseases [ACS Infect Dis] 2020 Feb 14; Vol. 6 (2), pp. 224-236. Date of Electronic Publication: 2019 Dec 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enfuvirtide/*pharmacology
HIV-1/*drug effects
HIV-1/*physiology
Protoporphyrins/*pharmacology
Virus Internalization/*drug effects
Cell Line ; Drug Synergism ; Humans ; Inhibitory Concentration 50 ; Liposomes/chemistry ; Nanoparticles/chemistry ; Polyethylene Glycols
Czasopismo naukowe
Tytuł :
Mutations of Glu560 within HIV-1 Envelope Glycoprotein N-terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry.
Autorzy :
Yuan C; Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang, China.
Wang JY; Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang, China.; Heilongjiang Provincial Key Laboratory of Infection and Immunity, Harbin, China.
Zhao HJ; Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang, China.
Li Y; Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang, China.; Heilongjiang Provincial Key Laboratory of Infection and Immunity, Harbin, China.; Key Laboratory of Pathogen Biology, Harbin, China.
Li D; Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang, China.; Heilongjiang Provincial Key Laboratory of Infection and Immunity, Harbin, China.; Key Laboratory of Pathogen Biology, Harbin, China.
Ling H; Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang, China. .; Heilongjiang Provincial Key Laboratory of Infection and Immunity, Harbin, China. .; Key Laboratory of Pathogen Biology, Harbin, China. .; Wu Lien-Teh Institute, Harbin Medical University, Harbin, China. .
Zhuang M; Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang, China. .; Heilongjiang Provincial Key Laboratory of Infection and Immunity, Harbin, China. .; Key Laboratory of Pathogen Biology, Harbin, China. .; Wu Lien-Teh Institute, Harbin Medical University, Harbin, China. .
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Źródło :
Retrovirology [Retrovirology] 2019 Dec 03; Vol. 16 (1), pp. 36. Date of Electronic Publication: 2019 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Viral/*genetics
HIV Envelope Protein gp41/*genetics
HIV Fusion Inhibitors/*pharmacology
HIV-1/*drug effects
HIV-1/*genetics
Virus Internalization/*drug effects
Cell Line ; Enfuvirtide/pharmacology ; HIV-1/physiology ; Humans ; Inhibitory Concentration 50 ; Mutation
Czasopismo naukowe
Tytuł :
Massively Parallel Profiling of HIV-1 Resistance to the Fusion Inhibitor Enfuvirtide.
Autorzy :
Dingens AS; Basic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. .; Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. .
Arenz D; Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. .
Overbaugh J; Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. .
Bloom JD; Basic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. .; Howard Hughes Medical Institute, Seattle, WA 98109, USA. .
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Źródło :
Viruses [Viruses] 2019 May 15; Vol. 11 (5). Date of Electronic Publication: 2019 May 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Anti-Retroviral Agents/*pharmacology
Drug Resistance, Viral/*drug effects
Drug Resistance, Viral/*genetics
HIV Fusion Inhibitors/*pharmacology
HIV-1/*drug effects
HIV-1/*genetics
Enfuvirtide/pharmacology ; Genotype ; HIV Envelope Protein gp41 ; HIV Infections/drug therapy ; High-Throughput Nucleotide Sequencing ; Humans ; Models, Molecular ; Mutation ; Viral Fusion Proteins/chemistry ; Viral Fusion Proteins/drug effects
Czasopismo naukowe
Tytuł :
Development and validation of reverse-phase high-performance liquid chromatographic (RP-HPLC) method for quantification of Efavirenz in Efavirenz-Enfuvirtide co-loaded polymer-lipid hybrid nanoparticles.
Autorzy :
Surve DH; Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Jhunjhunu, Rajasthan, 333031, India.
Jindal AB; Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Jhunjhunu, Rajasthan, 333031, India. Electronic address: .
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Źródło :
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2019 Oct 25; Vol. 175, pp. 112765. Date of Electronic Publication: 2019 Jul 12.
Typ publikacji :
Journal Article
MeSH Terms :
Benzoxazines/*chemistry
Enfuvirtide/*chemistry
Lipids/*chemistry
Nanoparticles/*chemistry
Polymers/*chemistry
Alkynes ; Calibration ; Chromatography, High Pressure Liquid/methods ; Chromatography, Reverse-Phase/methods ; Cyclopropanes ; Excipients/chemistry ; Indicators and Reagents/chemistry ; Limit of Detection ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Long-Acting HIV-1 Fusion Inhibitory Peptides and their Mechanisms of Action.
Autorzy :
Wang C; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Cheng S; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Zhang Y; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Ding Y; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Chong H; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Xing H; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Jiang S; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Li X; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. .
Ma L; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China. .
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Źródło :
Viruses [Viruses] 2019 Sep 02; Vol. 11 (9). Date of Electronic Publication: 2019 Sep 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV Fusion Inhibitors/*pharmacology
HIV-1/*drug effects
Amino Acid Sequence ; Animals ; Cell Line ; Circular Dichroism ; Drug Resistance, Viral/drug effects ; Drug Resistance, Viral/genetics ; Enfuvirtide/pharmacology ; HIV Envelope Protein gp41/chemistry ; HIV Envelope Protein gp41/metabolism ; HIV Envelope Protein gp41/pharmacology ; HIV Fusion Inhibitors/chemical synthesis ; HIV Fusion Inhibitors/chemistry ; HIV Fusion Inhibitors/pharmacokinetics ; HIV Infections/prevention & control ; HIV Infections/virology ; HIV-1/genetics ; Humans ; Membrane Fusion/drug effects ; Mutation ; Peptide Fragments/chemistry ; Peptide Fragments/metabolism ; Peptide Fragments/pharmacology ; Polyethylene Glycols/chemistry ; Protein Binding ; Protein Conformation, alpha-Helical ; Rats ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Structural and Thermodynamic Analysis of HIV-1 Fusion Inhibition Using Small gp41 Mimetic Proteins.
Autorzy :
Jurado S; Departamento de Química Física e Instituto de Biotecnología, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain.
Cano-Muñoz M; Departamento de Química Física e Instituto de Biotecnología, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain.
Morel B; Departamento de Química Física e Instituto de Biotecnología, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain.
Standoli S; Departamento de Química Física e Instituto de Biotecnología, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain.
Santarossa E; Departamento de Química Física e Instituto de Biotecnología, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain.
Moog C; INSERM U1109, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France.
Schmidt S; INSERM U1109, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France.
Laumond G; INSERM U1109, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Strasbourg, France.
Cámara-Artigas A; Department of Chemistry and Physics, Agrifood Campus of International Excellence (ceiA3) and CIAMBITAL, University of Almería, Carretera de Sacramento, 04120 Almeria, Spain.
Conejero-Lara F; Departamento de Química Física e Instituto de Biotecnología, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2019 Aug 09; Vol. 431 (17), pp. 3091-3106. Date of Electronic Publication: 2019 Jun 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Thermodynamics*
HIV Envelope Protein gp41/*chemistry
HIV Envelope Protein gp41/*metabolism
HIV-1/*metabolism
Virus Internalization/*drug effects
Amino Acid Sequence ; Anti-HIV Agents/pharmacology ; Crystallography, X-Ray ; Enfuvirtide/antagonists & inhibitors ; HIV Envelope Protein gp41/genetics ; HIV-1/drug effects ; HIV-1/genetics ; Models, Molecular ; Mutation ; Peptides ; Protein Conformation ; Sequence Analysis, Protein
Czasopismo naukowe
Tytuł :
HIV-1 anchor inhibitors and membrane fusion inhibitors target distinct but overlapping steps in virus entry.
Autorzy :
Eggink D; From the Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam University Medical Centers (Amsterdam UMC), Location AMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Bontjer I; From the Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam University Medical Centers (Amsterdam UMC), Location AMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
de Taeye SW; From the Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam University Medical Centers (Amsterdam UMC), Location AMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Langedijk JPM; Pepscan Therapeutics BV, Zuidersluisweg 2, 8243 RC Lelystad, The Netherlands.
Berkhout B; From the Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam University Medical Centers (Amsterdam UMC), Location AMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Sanders RW; From the Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam University Medical Centers (Amsterdam UMC), Location AMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; the Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10065. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2019 Apr 12; Vol. 294 (15), pp. 5736-5746. Date of Electronic Publication: 2019 Jan 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Viral*/drug effects
Drug Resistance, Viral*/genetics
Mutation*
env Gene Products, Human Immunodeficiency Virus*/antagonists & inhibitors
env Gene Products, Human Immunodeficiency Virus*/genetics
env Gene Products, Human Immunodeficiency Virus*/metabolism
HIV-1/*physiology
Peptide Fragments/*pharmacology
Virus Internalization/*drug effects
alpha 1-Antitrypsin/*pharmacology
CD4 Antigens/genetics ; CD4 Antigens/metabolism ; Cell Line ; Enfuvirtide/chemistry ; Enfuvirtide/pharmacology ; Humans ; Maraviroc/chemistry ; Maraviroc/pharmacology ; Peptide Fragments/chemistry ; Peptide Fragments/genetics ; alpha 1-Antitrypsin/chemistry ; alpha 1-Antitrypsin/genetics
Czasopismo naukowe
Tytuł :
Transdermal Delivery of Enfuvirtide in a Porcine Model Using a Low-Frequency, Low-Power Ultrasound Transducer Patch.
Autorzy :
Snook KA; Actuated Medical, Inc., Bellefonte, Pennsylvania, USA. Electronic address: .
Van Ess R 2nd; Actuated Medical, Inc., Bellefonte, Pennsylvania, USA.
Werner JR; Animal Resource Program, The Pennsylvania State University, University Park, Pennsylvania, USA.
Clement RS; Actuated Medical, Inc., Bellefonte, Pennsylvania, USA.
Ocon-Grove OM; Actuated Medical, Inc., Bellefonte, Pennsylvania, USA.
Dodds JW; Animal Resource Program, The Pennsylvania State University, University Park, Pennsylvania, USA.
Ryan KJ; Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Acosta EP; Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Zurlo JJ; Infectious Diseases, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, USA.
Mulvihill ML; Actuated Medical, Inc., Bellefonte, Pennsylvania, USA.
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Źródło :
Ultrasound in medicine & biology [Ultrasound Med Biol] 2019 Feb; Vol. 45 (2), pp. 513-525. Date of Electronic Publication: 2018 Dec 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Transdermal Patch*
Drug Delivery Systems/*methods
Enfuvirtide/*administration & dosage
HIV Fusion Inhibitors/*administration & dosage
Ultrasonics/*methods
Administration, Cutaneous ; Animals ; Female ; Male ; Models, Animal ; Skin Absorption ; Swine ; Transducers
Czasopismo naukowe
Tytuł :
Design and Characterization of Cholesterylated Peptide HIV-1/2 Fusion Inhibitors with Extremely Potent and Long-Lasting Antiviral Activity.
Autorzy :
Zhu Y; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chong H; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yu D; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Guo Y; Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Zhou Y; Beijing Institute of Microbiology and Epidemiology, Beijing, China.
He Y; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China .; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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Źródło :
Journal of virology [J Virol] 2019 May 15; Vol. 93 (11). Date of Electronic Publication: 2019 May 15 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enfuvirtide/*pharmacology
HIV Infections/*therapy
Lipopeptides/*pharmacology
Animals ; Anti-HIV Agents/pharmacology ; Anti-Retroviral Agents/therapeutic use ; Antiviral Agents/pharmacology ; Cell Line ; Drug Design ; Drug Resistance, Viral/drug effects ; HEK293 Cells ; HIV Envelope Protein gp41/metabolism ; HIV Fusion Inhibitors/pharmacology ; HIV-1/physiology ; HIV-2/physiology ; Humans ; Macaca mulatta ; Membrane Fusion/drug effects ; Peptide Fragments/metabolism ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
Structural and functional characterization of HIV-1 cell fusion inhibitor T20.
Autorzy :
Zhang X; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College.; College of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University.
Ding X; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College.
Zhu Y; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College.
Chong H; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College.
Cui S; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College.
He J; College of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University.
Wang X; Ministry of Education Key Laboratory of Protein Science, Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.
He Y; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College.; College of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University.
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Źródło :
AIDS (London, England) [AIDS] 2019 Jan 27; Vol. 33 (1), pp. 1-11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enfuvirtide/*chemistry
Enfuvirtide/*pharmacology
HIV Fusion Inhibitors/*chemistry
HIV Fusion Inhibitors/*pharmacology
Virus Internalization/*drug effects
Calorimetry ; Circular Dichroism ; Crystallography, X-Ray ; DNA Mutational Analysis ; Drug Resistance, Viral ; Electrophoresis, Polyacrylamide Gel ; Protein Conformation
Czasopismo naukowe
Tytuł :
Evolved Proteins Inhibit Entry of Enfuvirtide-Resistant HIV-1.
Autorzy :
Ikeda T; Department of Biochemistry, Molecular Biology, and Biophysics , University of Minnesota , 2231 6th Street S.E. , Minneapolis , Minnesota 55455 , United States.; Howard Hughes Medical Institute , University of Minnesota , Minneapolis , Minnesota , United States.
Tennyson RL; Department of Chemistry , Colorado State University , 200 W. Lake Street , Fort Collins , Colorado 80523 , United States.
Walker SN; Department of Chemistry , Colorado State University , 200 W. Lake Street , Fort Collins , Colorado 80523 , United States.
Harris RS; Department of Biochemistry, Molecular Biology, and Biophysics , University of Minnesota , 2231 6th Street S.E. , Minneapolis , Minnesota 55455 , United States.; Howard Hughes Medical Institute , University of Minnesota , Minneapolis , Minnesota , United States.
McNaughton BR; Department of Chemistry , Colorado State University , 200 W. Lake Street , Fort Collins , Colorado 80523 , United States.
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Źródło :
ACS infectious diseases [ACS Infect Dis] 2019 Apr 12; Vol. 5 (4), pp. 634-640. Date of Electronic Publication: 2019 Mar 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Drug Resistance, Viral*
Enfuvirtide/*pharmacology
HIV Envelope Protein gp41/*chemistry
HIV Fusion Inhibitors/*pharmacology
HIV-1/*drug effects
Peptides/*pharmacology
Virus Internalization/*drug effects
HIV Envelope Protein gp41/metabolism ; HIV Infections/virology ; HIV-1/genetics ; HIV-1/physiology ; Humans ; Peptides/chemistry ; Peptides/genetics ; Protein Conformation, alpha-Helical ; Protein Engineering
Czasopismo naukowe

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