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Tytuł:
Thermostable chaperone-based polypeptide biosynthesis: Enfuvirtide model product quality and protocol-related impurities.
Autorzy:
Zenin V; Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russian Federation.
Tsedilin A; Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russian Federation.
Yurkova M; Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russian Federation.
Siniavin A; Ivanovsky Institute of Virology, N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russian Federation.
Fedorov A; Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow, Russian Federation.
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Źródło:
PloS one [PLoS One] 2023 Jun 08; Vol. 18 (6), pp. e0286752. Date of Electronic Publication: 2023 Jun 08 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Infections*/drug therapy
HIV Fusion Inhibitors*/pharmacology
Humans ; Enfuvirtide/pharmacology ; Peptide Fragments/chemistry ; HIV Envelope Protein gp41/chemistry ; Peptides/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Glu143 Residue Might Play a Significant Role in T20 Peptide Binding to HIV-1 Receptor gp41: An In Silico Study.
Autorzy:
Alaofi AL; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jun 20; Vol. 27 (12). Date of Electronic Publication: 2022 Jun 20.
Typ publikacji:
Journal Article
MeSH Terms:
HIV Fusion Inhibitors*/pharmacology
HIV-1*/genetics
HIV-1*/metabolism
Enfuvirtide/chemistry ; Enfuvirtide/pharmacology ; HIV Antibodies/metabolism ; HIV Envelope Protein gp41/genetics ; HIV Envelope Protein gp41/metabolism ; Peptide Fragments/chemistry ; Peptide Fragments/genetics ; Peptide Fragments/pharmacology ; Peptides/genetics ; Peptides/metabolism ; Peptides/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In Vitro Selection and Characterization of HIV-1 Variants with Increased Resistance to LP-40, Enfuvirtide-Based Lipopeptide Inhibitor.
Autorzy:
Hu Y; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Yu W; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Geng X; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Zhu Y; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Chong H; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
He Y; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jun 14; Vol. 23 (12). Date of Electronic Publication: 2022 Jun 14.
Typ publikacji:
Journal Article
MeSH Terms:
HIV Fusion Inhibitors*/chemistry
HIV Fusion Inhibitors*/pharmacology
HIV-1*
Amino Acids/metabolism ; Drug Resistance, Viral/genetics ; Enfuvirtide/chemistry ; Enfuvirtide/pharmacology ; HIV Envelope Protein gp41/chemistry ; HIV Envelope Protein gp41/genetics ; HIV Envelope Protein gp41/pharmacology ; Lipopeptides/chemistry ; Mutation ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Peptide Fragments/pharmacology ; Virus Internalization
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Massively Parallel Profiling of HIV-1 Resistance to the Fusion Inhibitor Enfuvirtide.
Autorzy:
Dingens AS; Basic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. .; Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. .
Arenz D; Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. .
Overbaugh J; Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. .
Bloom JD; Basic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. .; Howard Hughes Medical Institute, Seattle, WA 98109, USA. .
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Źródło:
Viruses [Viruses] 2019 May 15; Vol. 11 (5). Date of Electronic Publication: 2019 May 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Anti-Retroviral Agents/*pharmacology
Drug Resistance, Viral/*drug effects
Drug Resistance, Viral/*genetics
HIV Fusion Inhibitors/*pharmacology
HIV-1/*drug effects
HIV-1/*genetics
Enfuvirtide/pharmacology ; Genotype ; HIV Envelope Protein gp41 ; HIV Infections/drug therapy ; High-Throughput Nucleotide Sequencing ; Humans ; Models, Molecular ; Mutation ; Viral Fusion Proteins/chemistry ; Viral Fusion Proteins/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mutations of Glu560 within HIV-1 Envelope Glycoprotein N-terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry.
Autorzy:
Yuan C; Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang, China.
Wang JY; Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang, China.; Heilongjiang Provincial Key Laboratory of Infection and Immunity, Harbin, China.
Zhao HJ; Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang, China.
Li Y; Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang, China.; Heilongjiang Provincial Key Laboratory of Infection and Immunity, Harbin, China.; Key Laboratory of Pathogen Biology, Harbin, China.
Li D; Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang, China.; Heilongjiang Provincial Key Laboratory of Infection and Immunity, Harbin, China.; Key Laboratory of Pathogen Biology, Harbin, China.
Ling H; Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang, China. .; Heilongjiang Provincial Key Laboratory of Infection and Immunity, Harbin, China. .; Key Laboratory of Pathogen Biology, Harbin, China. .; Wu Lien-Teh Institute, Harbin Medical University, Harbin, China. .
Zhuang M; Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang, China. .; Heilongjiang Provincial Key Laboratory of Infection and Immunity, Harbin, China. .; Key Laboratory of Pathogen Biology, Harbin, China. .; Wu Lien-Teh Institute, Harbin Medical University, Harbin, China. .
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Źródło:
Retrovirology [Retrovirology] 2019 Dec 03; Vol. 16 (1), pp. 36. Date of Electronic Publication: 2019 Dec 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Resistance, Viral/*genetics
HIV Envelope Protein gp41/*genetics
HIV Fusion Inhibitors/*pharmacology
HIV-1/*drug effects
HIV-1/*genetics
Virus Internalization/*drug effects
Cell Line ; Enfuvirtide/pharmacology ; HIV-1/physiology ; Humans ; Inhibitory Concentration 50 ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Long-Acting HIV-1 Fusion Inhibitory Peptides and their Mechanisms of Action.
Autorzy:
Wang C; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Cheng S; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Zhang Y; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Ding Y; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Chong H; MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology and Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Xing H; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Jiang S; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Li X; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. .
Ma L; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China. .
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Źródło:
Viruses [Viruses] 2019 Sep 02; Vol. 11 (9). Date of Electronic Publication: 2019 Sep 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Fusion Inhibitors/*pharmacology
HIV-1/*drug effects
Amino Acid Sequence ; Animals ; Cell Line ; Circular Dichroism ; Drug Resistance, Viral/drug effects ; Drug Resistance, Viral/genetics ; Enfuvirtide/pharmacology ; HIV Envelope Protein gp41/chemistry ; HIV Envelope Protein gp41/metabolism ; HIV Envelope Protein gp41/pharmacology ; HIV Fusion Inhibitors/chemical synthesis ; HIV Fusion Inhibitors/chemistry ; HIV Fusion Inhibitors/pharmacokinetics ; HIV Infections/prevention & control ; HIV Infections/virology ; HIV-1/genetics ; Humans ; Membrane Fusion/drug effects ; Mutation ; Peptide Fragments/chemistry ; Peptide Fragments/metabolism ; Peptide Fragments/pharmacology ; Polyethylene Glycols/chemistry ; Protein Binding ; Protein Conformation, alpha-Helical ; Rats ; Virus Replication/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The improved efficacy of Sifuvirtide compared with enfuvirtide might be related to its selectivity for the rigid biomembrane, as determined through surface plasmon resonance.
Autorzy:
Cao P; Laboratory of Hematological Pharmacology, State Key Laboratory of Drug Metabolism, Beijing Institute of Transfusion Medicine, Beijing, People's Republic of China.; Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.
Dou G; Laboratory of Hematological Pharmacology, State Key Laboratory of Drug Metabolism, Beijing Institute of Transfusion Medicine, Beijing, People's Republic of China.
Cheng Y; Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.
Che J; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.
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Źródło:
PloS one [PLoS One] 2017 Feb 16; Vol. 12 (2), pp. e0171567. Date of Electronic Publication: 2017 Feb 16 (Print Publication: 2017).
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
HIV Envelope Protein gp41/*chemistry
HIV Fusion Inhibitors/*chemistry
Lipid Bilayers/*chemistry
Peptide Fragments/*chemistry
Peptides/*chemistry
Surface Plasmon Resonance/*methods
Enfuvirtide ; HIV Envelope Protein gp41/pharmacology ; HIV Fusion Inhibitors/pharmacology ; Humans ; Peptide Fragments/pharmacology ; Peptides/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Incidence and risk factors for liver enzymes elevations in highly treatment-experienced patients switching from enfuvirtide to raltegravir: a sub-study of the ANRS-138 EASIER trial.
Autorzy:
de Castro N; Department of Infectious Diseases, Assistance Publique Hôpitaux de Paris, Saint-Louis Hospital, University of Paris Diderot Paris 7, 1 avenue Claude Vellefaux, 75010 Paris, France.
Braun J; INSERM SC10-US019, Villejuif, France.
Charreau I; INSERM SC10-US019, Villejuif, France.
Lafeuillade A; Department of Infectiology and Hematology, Font-Pré Hospital, Toulon, France.
Viard JP; Department of Infectious Diseases, Hôtel-Dieu Hospital, Paris, France.
Allavena C; Department of Infectious Diseases, Hôtel-Dieu Hospital, Nantes, France.
Aboulker JP; INSERM SC10-US019, Villejuif, France.
Molina JM; Department of Infectious Diseases, Assistance Publique Hôpitaux de Paris, Saint-Louis Hospital, University of Paris Diderot Paris 7, 1 avenue Claude Vellefaux, 75010 Paris, France.
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Corporate Authors:
EASIER ANRS 138 study group
Źródło:
AIDS research and therapy [AIDS Res Ther] 2016 Apr 02; Vol. 13, pp. 17. Date of Electronic Publication: 2016 Apr 02 (Print Publication: 2016).
Typ publikacji:
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Chemical and Drug Induced Liver Injury/*etiology
Drug Substitution/*adverse effects
HIV Envelope Protein gp41/*adverse effects
HIV Fusion Inhibitors/*adverse effects
HIV Infections/*drug therapy
HIV Integrase Inhibitors/*adverse effects
Peptide Fragments/*adverse effects
Raltegravir Potassium/*adverse effects
Adult ; Alanine Transaminase/blood ; Chemical and Drug Induced Liver Injury/epidemiology ; Enfuvirtide ; Female ; HIV Envelope Protein gp41/therapeutic use ; HIV Fusion Inhibitors/therapeutic use ; HIV Integrase Inhibitors/therapeutic use ; Humans ; Incidence ; Liver Function Tests ; Male ; Middle Aged ; Peptide Fragments/therapeutic use ; Raltegravir Potassium/therapeutic use ; Risk Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The C4 region as a target for HIV entry inhibitors--NMR mapping of the interacting segments of T20 and gp120.
Autorzy:
Moseri A; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Biron Z; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
Arshava B; Department of Chemistry and Macromolecular Assembly Institute, College of Staten Island of the City University of New York, Staten Island, NY, USA.
Scherf T; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel.
Naider F; Department of Chemistry and Macromolecular Assembly Institute, College of Staten Island of the City University of New York, Staten Island, NY, USA.
Anglister J; Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
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Źródło:
The FEBS journal [FEBS J] 2015 Dec; Vol. 282 (24), pp. 4643-57. Date of Electronic Publication: 2015 Oct 22.
Typ publikacji:
Editorial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Molecular*
Virus Internalization*/drug effects
HIV Envelope Protein gp120/*metabolism
HIV Envelope Protein gp41/*metabolism
HIV Fusion Inhibitors/*metabolism
HIV-1/*drug effects
Peptide Fragments/*metabolism
Peptides/*metabolism
Amino Acid Substitution ; CD4 Antigens/chemistry ; CD4 Antigens/metabolism ; Enfuvirtide ; HEK293 Cells ; HIV Envelope Protein gp120/antagonists & inhibitors ; HIV Envelope Protein gp120/chemistry ; HIV Envelope Protein gp120/genetics ; HIV Envelope Protein gp41/chemistry ; HIV Envelope Protein gp41/genetics ; HIV Envelope Protein gp41/pharmacology ; HIV Fusion Inhibitors/chemistry ; HIV Fusion Inhibitors/pharmacology ; HIV-1/physiology ; Humans ; Hydrophobic and Hydrophilic Interactions ; Kinetics ; Ligands ; Magnetic Resonance Spectroscopy ; Mutation ; Peptide Fragments/chemistry ; Peptide Fragments/genetics ; Peptide Fragments/pharmacology ; Peptides/chemistry ; Peptides/genetics ; Peptides/pharmacology ; Protein Interaction Domains and Motifs ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Recombinant Proteins/pharmacology ; Solubility ; Surface Plasmon Resonance
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy.
Autorzy:
Zhu X; Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Shanghai Public Health Clinical Center, Fudan University, Shanghai, 200032, China.
Zhu Y; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Ye S; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Wang Q; Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Shanghai Public Health Clinical Center, Fudan University, Shanghai, 200032, China.
Xu W; Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Shanghai Public Health Clinical Center, Fudan University, Shanghai, 200032, China.
Su S; Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Shanghai Public Health Clinical Center, Fudan University, Shanghai, 200032, China.
Sun Z; Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Shanghai Public Health Clinical Center, Fudan University, Shanghai, 200032, China.
Yu F; 1] Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Shanghai Public Health Clinical Center, Fudan University, Shanghai, 200032, China [2] Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York 10065, USA.
Liu Q; Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Shanghai Public Health Clinical Center, Fudan University, Shanghai, 200032, China.
Wang C; Beijing Institute of Pharmacology &Toxicology, 27 Tai-Ping Road, Beijing, 100850, China.
Zhang T; Beijing Institute of Pharmacology &Toxicology, 27 Tai-Ping Road, Beijing, 100850, China.
Zhang Z; Beijing Institute of Pharmacology &Toxicology, 27 Tai-Ping Road, Beijing, 100850, China.
Zhang X; 1] Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Shanghai Public Health Clinical Center, Fudan University, Shanghai, 200032, China [2] Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 201508, China.
Xu J; 1] Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Shanghai Public Health Clinical Center, Fudan University, Shanghai, 200032, China [2] Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 201508, China.
Du L; Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York 10065, USA.
Liu K; Beijing Institute of Pharmacology &Toxicology, 27 Tai-Ping Road, Beijing, 100850, China.
Lu L; Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Shanghai Public Health Clinical Center, Fudan University, Shanghai, 200032, China.
Zhang R; 1] National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China [2] National Center for Protein Science Shanghai, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 201210, China.
Jiang S; 1] Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Shanghai Public Health Clinical Center, Fudan University, Shanghai, 200032, China [2] Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York 10065, USA.
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Źródło:
Scientific reports [Sci Rep] 2015 Aug 19; Vol. 5, pp. 13028. Date of Electronic Publication: 2015 Aug 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Envelope Protein gp41/*pharmacology
HIV Fusion Inhibitors/*chemistry
HIV Fusion Inhibitors/*pharmacology
Peptide Fragments/*pharmacology
Peptides/*pharmacology
Amino Acid Sequence ; Animals ; Biophysical Phenomena/drug effects ; Crystallography, X-Ray ; Endopeptidase K/metabolism ; Enfuvirtide ; HIV Antibodies/immunology ; HIV Envelope Protein gp41/metabolism ; HIV Fusion Inhibitors/pharmacokinetics ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/immunology ; HIV-1/isolation & purification ; Liver/drug effects ; Liver/metabolism ; Male ; Models, Molecular ; Molecular Sequence Data ; Peptides/chemistry ; Protein Structure, Secondary ; Proteolysis/drug effects ; Rats, Sprague-Dawley
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effect of amphipathic HIV fusion inhibitor peptides on POPC and POPC/cholesterol membrane properties: a molecular simulation study.
Autorzy:
Martins do Canto AM; Department of Chemistry, School of Science and Technology, University of Évora, Rua Romão Ramalho 59, 7000-671 Évora, Portugal.
Carvalho AJ
Ramalho JP
Loura LM
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2013 Jul 15; Vol. 14 (7), pp. 14724-43. Date of Electronic Publication: 2013 Jul 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Molecular Dynamics Simulation*
Cholesterol/*chemistry
HIV Fusion Inhibitors/*metabolism
Lipid Bilayers/*metabolism
Peptides/*metabolism
Phosphatidylcholines/*chemistry
Enfuvirtide ; HIV/metabolism ; HIV Envelope Protein gp41/chemistry ; HIV Envelope Protein gp41/metabolism ; HIV Fusion Inhibitors/chemistry ; Humans ; Hydrogen Bonding ; Lipid Bilayers/chemistry ; Peptide Fragments/chemistry ; Peptide Fragments/metabolism ; Peptides/chemistry ; Protein Binding ; Protein Structure, Tertiary
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Dynamics of enfuvirtide resistance mutations in enfuvirtide-experienced patients remaining in virological failure under salvage therapy.
Autorzy:
Charpentier C; Laboratoire de Virologie, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
Jenabian MA
Piketty C
Karmochkine M
Tisserand P
Laureillard D
Bélec L
Si-Mohamed A
Weiss L
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Źródło:
Scandinavian journal of infectious diseases [Scand J Infect Dis] 2011 May; Vol. 43 (5), pp. 373-9. Date of Electronic Publication: 2011 Feb 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Salvage Therapy*
Drug Resistance, Viral/*genetics
HIV Envelope Protein gp41/*pharmacology
HIV Fusion Inhibitors/*pharmacology
HIV Infections/*drug therapy
HIV-1/*drug effects
Peptide Fragments/*pharmacology
Adult ; CD4 Lymphocyte Count ; Drug Resistance, Viral/drug effects ; Enfuvirtide ; Evolution, Molecular ; Female ; Follow-Up Studies ; Genotype ; HIV Envelope Protein gp41/therapeutic use ; HIV Fusion Inhibitors/therapeutic use ; HIV Infections/virology ; HIV-1/genetics ; Humans ; Leukocytes, Mononuclear/virology ; Male ; Middle Aged ; Mutation ; Peptide Fragments/therapeutic use ; Prospective Studies ; RNA, Viral/blood ; Treatment Failure ; Viral Load
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The suppression of immune activation during enfuvirtide-based salvage therapy is associated with reduced CCR5 expression and decreased concentrations of circulating interleukin-12 and IP-10 during 48 weeks of longitudinal follow-up.
Autorzy:
Carsenti-Dellamonica H; Infectiology Unit, University Nice Sophia-Antipolis, Nice, France.
Saïdi H
Ticchioni M
Guillouet de Salvador F
Dufayard Cottalorda J
Garraffo R
Dellamonica P
Durant J
Gougeon ML
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Źródło:
HIV medicine [HIV Med] 2011 Feb; Vol. 12 (2), pp. 65-77.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CD4-Positive T-Lymphocytes/*immunology
Chemokine CXCL10/*blood
HIV Envelope Protein gp41/*therapeutic use
HIV Fusion Inhibitors/*therapeutic use
HIV Infections/*drug therapy
HIV Infections/*immunology
Interleukin-12/*blood
Peptide Fragments/*therapeutic use
Receptors, CCR5/*metabolism
Adolescent ; Adult ; Antiretroviral Therapy, Highly Active/adverse effects ; CD4-Positive T-Lymphocytes/drug effects ; Enfuvirtide ; HIV-1/drug effects ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Salvage Therapy ; Viral Load ; Virus Replication/drug effects ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Enfuvirtide injection site reactions: a clinical and histopathological appraisal.
Autorzy:
Wallace BJ; Department of Dermatology, St Vincent's Hospital, New South Wales, Australia. />Tan KB
Pett SL
Cooper DA
Kossard S
Whitfeld MJ
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Źródło:
The Australasian journal of dermatology [Australas J Dermatol] 2011 Feb; Vol. 52 (1), pp. 19-26. Date of Electronic Publication: 2011 Jan 12.
Typ publikacji:
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Envelope Protein gp41/*adverse effects
HIV Fusion Inhibitors/*adverse effects
Peptide Fragments/*adverse effects
Skin/*drug effects
Skin/*pathology
Biopsy ; Enfuvirtide ; Humans ; Injections, Subcutaneous/adverse effects ; Male ; Middle Aged ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Impact of the HIV-1 env genetic context outside HR1-HR2 on resistance to the fusion inhibitor enfuvirtide and viral infectivity in clinical isolates.
Autorzy:
Baatz F; Laboratory of Retrovirology, CRP-Santé, Luxembourg, Luxembourg.
Nijhuis M
Lemaire M
Riedijk M
Wensing AM
Servais JY
van Ham PM
Hoepelman AI
Koopmans PP
Sprenger HG
Devaux C
Schmit JC
Perez Bercoff D
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Źródło:
PloS one [PLoS One] 2011; Vol. 6 (7), pp. e21535. Date of Electronic Publication: 2011 Jul 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Resistance, Viral/*genetics
HIV Envelope Protein gp41/*pharmacology
HIV Fusion Inhibitors/*pharmacology
HIV-1/*genetics
Peptide Fragments/*pharmacology
env Gene Products, Human Immunodeficiency Virus/*genetics
Base Sequence ; Drug Resistance, Viral/drug effects ; Enfuvirtide ; Genotype ; HEK293 Cells ; HIV-1/drug effects ; HIV-1/pathogenicity ; Humans ; Inhibitory Concentration 50 ; Phenotype ; Phylogeny ; Protein Structure, Secondary ; Recombination, Genetic/genetics ; Tropism/drug effects ; Tropism/genetics ; Virion
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The effects of enfuvirtide therapy on body composition and metabolic parameters over 48 weeks in the TORO body imaging substudy.
Autorzy:
Cooper DA; National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia. />Cordery DV
Reiss P
Henry K
Nelson M
O'Hearn M
Reynes J
Arastéh K
Chung J
Rowell L
Guimaraes D
Bertasso A
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Corporate Authors:
TORO 1 and TORO 2 Study Groups
Źródło:
HIV medicine [HIV Med] 2011 Jan; Vol. 12 (1), pp. 31-9.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Body Composition/*drug effects
Dyslipidemias/*chemically induced
HIV Envelope Protein gp41/*adverse effects
HIV Fusion Inhibitors/*adverse effects
HIV Infections/*drug therapy
Peptide Fragments/*adverse effects
Absorptiometry, Photon ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antiretroviral Therapy, Highly Active/adverse effects ; Antiretroviral Therapy, Highly Active/methods ; Body Weight/drug effects ; Dyslipidemias/epidemiology ; Enfuvirtide ; Female ; HIV Envelope Protein gp41/pharmacology ; HIV Fusion Inhibitors/pharmacology ; HIV Infections/metabolism ; HIV-Associated Lipodystrophy Syndrome/chemically induced ; Humans ; Male ; Middle Aged ; Peptide Fragments/pharmacology ; Tomography, X-Ray Computed ; Waist Circumference/drug effects ; Waist-Hip Ratio ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Treatment-mediated alterations in HIV fitness preserve CD4+ T cell counts but have minimal effects on viral load.
Autorzy:
Vaidya NK; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
Rong L
Marconi VC
Kuritzkes DR
Deeks SG
Perelson AS
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2010 Nov 24; Vol. 6 (11), pp. e1001012. Date of Electronic Publication: 2010 Nov 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
CD4-Positive T-Lymphocytes/*drug effects
HIV Envelope Protein gp41/*administration & dosage
HIV Fusion Inhibitors/*administration & dosage
HIV Infections/*drug therapy
HIV-1/*physiology
Peptide Fragments/*administration & dosage
CD4 Lymphocyte Count ; Drug Resistance, Viral ; Enfuvirtide ; HIV Infections/immunology ; HIV Infections/virology ; Host-Pathogen Interactions ; Humans ; Models, Biological ; Prognosis ; Treatment Outcome ; Viral Load/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Fuzeon-induced collagenophagic granuloma: a peculiar granulomatous injection site reaction to Fuzeon--a case report and review of literature.
Autorzy:
Sidhu HK; Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Brown University, Providence, Rhode Island 02903, USA. />Chaffee BH
Tvetenstrand CD
Sidhu JS
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Źródło:
International journal of surgical pathology [Int J Surg Pathol] 2010 Oct; Vol. 18 (5), pp. 384-7. Date of Electronic Publication: 2009 Feb 17.
Typ publikacji:
Case Reports; Journal Article; Review
MeSH Terms:
Collagen/*metabolism
Granuloma, Foreign-Body/*chemically induced
HIV Envelope Protein gp41/*adverse effects
HIV Fusion Inhibitors/*adverse effects
Peptide Fragments/*adverse effects
Phagocytosis/*drug effects
Enfuvirtide ; Giant Cells/pathology ; Granuloma, Foreign-Body/metabolism ; Granuloma, Foreign-Body/pathology ; Humans ; Injections, Subcutaneous ; Male ; Middle Aged ; Phagocytosis/physiology ; Withholding Treatment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
HIV-1 fusion inhibitor peptides enfuvirtide and T-1249 interact with erythrocyte and lymphocyte membranes.
Autorzy:
Matos PM; Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.
Castanho MA
Santos NC
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Źródło:
PloS one [PLoS One] 2010 Mar 23; Vol. 5 (3), pp. e9830. Date of Electronic Publication: 2010 Mar 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Membrane/*drug effects
Erythrocyte Membrane/*drug effects
HIV Envelope Protein gp41/*pharmacology
HIV Fusion Inhibitors/*pharmacology
Lymphocytes/*drug effects
Peptide Fragments/*pharmacology
Enfuvirtide ; HIV Fusion Inhibitors/chemistry ; Humans ; Kinetics ; Leukocytes, Mononuclear/drug effects ; Lipids/chemistry ; Microscopy, Confocal/methods ; Peptides/chemistry ; Protein Binding ; Protein Structure, Tertiary ; Pyridinium Compounds/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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