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Tytuł :
Topical treatment with a mu opioid receptor agonist alleviates corneal allodynia and corneal nerve sensitization in mice.
Autorzy :
Joubert F; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 Rue Moreau, F-75012, Paris, France.
Guerrero-Moreno A; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 Rue Moreau, F-75012, Paris, France.
Fakih D; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 Rue Moreau, F-75012, Paris, France; R&D Department, Laboratoires Théa, 12 Rue Louis Biérot, F-63000, Clermont-Ferrand, France.
Reboussin E; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 Rue Moreau, F-75012, Paris, France.
Gaveriaux-Ruff C; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, CNRS, UMR7104, INSERM U1258, Ecole Supérieure de Biotechnologie de Strasbourg, Illkirch, Strasbourg, France.
Acosta MC; Instituto de Neurociencias Universidad Miguel Hernández-CSIC, San Juan de Alicante, Alicante, Spain.
Gallar J; Instituto de Neurociencias Universidad Miguel Hernández-CSIC, San Juan de Alicante, Alicante, Spain; Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain.
Sahel JA; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 Rue Moreau, F-75012, Paris, France; CHNO des Quinze-Vingts, INSERM-DGOS CIC 1423, 28 Rue de Charenton, F-75012, Paris, France; Fondation Ophtalmologique Rothschild, 29 Rue Manin, F-75019, Paris, France; Department of Ophthalmology, The University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, United States.
Bodineau L; Sorbonne Université, INSERM, UMR_S1158 Neurophysiologie Respiratoire Expérimentale et Clinique, F-75013, Paris, France.
Baudouin C; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 Rue Moreau, F-75012, Paris, France; CHNO des Quinze-Vingts, INSERM-DGOS CIC 1423, 28 Rue de Charenton, F-75012, Paris, France; Department of Ophthalmology, Ambroise Paré Hospital, AP-HP, Paris-Saclay University, F-92100 Boulogne-Billancourt, France.
Rostène W; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 Rue Moreau, F-75012, Paris, France.
Mélik-Parsadaniantz S; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 Rue Moreau, F-75012, Paris, France.
Réaux-Le Goazigo A; Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 Rue Moreau, F-75012, Paris, France. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Dec; Vol. 132, pp. 110794. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Analgesics, Opioid/*pharmacology
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/*pharmacology
Eye Pain/*drug therapy
Receptors, Opioid, mu/*agonists
Administration, Ophthalmic ; Analgesics, Opioid/administration & dosage ; Animals ; Cornea/drug effects ; Cornea/innervation ; Cornea/pathology ; Corneal Diseases/drug therapy ; Corneal Diseases/pathology ; Disease Models, Animal ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/administration & dosage ; Inflammation/drug therapy ; Inflammation/pathology ; Male ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
The paradoxical role of methionine enkephalin in tumor responses.
Autorzy :
Tuo Y; Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
Tian C; Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
Lu L; Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
Xiang M; Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 Sep 05; Vol. 882, pp. 173253. Date of Electronic Publication: 2020 Jun 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Enkephalin, Methionine/*therapeutic use
Neoplasms/*drug therapy
Animals ; Antineoplastic Agents/pharmacology ; Enkephalin, Methionine/pharmacology ; Humans ; Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Effects of botulinum toxin A on endometriosis‑associated pain and its related mechanism.
Autorzy :
Tian F; Department of Anesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200090, P.R. China.
Cheng W; Massage Department, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, P.R. China.
Hu J; Department of Anesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200090, P.R. China.
Huang S; Department of Anesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200090, P.R. China.
Sun S; Department of Anesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200090, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2020 Nov; Vol. 22 (5), pp. 4351-4359. Date of Electronic Publication: 2020 Sep 10.
Typ publikacji :
Journal Article; Retracted Publication
MeSH Terms :
Botulinum Toxins, Type A/*administration & dosage
Endometriosis/*drug therapy
Enkephalin, Methionine/*metabolism
Norepinephrine/*metabolism
Pain/*drug therapy
Adult ; Animals ; Botulinum Toxins, Type A/pharmacology ; Cell Survival ; Disease Models, Animal ; Endometriosis/complications ; Endometriosis/etiology ; Endometriosis/metabolism ; Enkephalin, Methionine/cerebrospinal fluid ; Female ; Glucose/adverse effects ; Humans ; Mice ; Mice, Inbred BALB C ; Norepinephrine/cerebrospinal fluid ; PC12 Cells ; Pain/etiology ; Pain/metabolism ; Rats
Czasopismo naukowe
Tytuł :
Sialorphin Potentiates Effects of [Met ]Enkephalin without Toxicity by Action other than Peptidase Inhibition.
Autorzy :
Kan T; Departments of Anesthesiology (T.K., M.W., M.Mi., K.I., M.Ma., Ta.S., To.S.) and Clinical Pharmacology (M.Y., H.K.) and Education and Research Support Center (K.I.), Tokai University School of Medicine, Kanagawa, Japan.
Yoshikawa M; Departments of Anesthesiology (T.K., M.W., M.Mi., K.I., M.Ma., Ta.S., To.S.) and Clinical Pharmacology (M.Y., H.K.) and Education and Research Support Center (K.I.), Tokai University School of Medicine, Kanagawa, Japan .
Watanabe M; Departments of Anesthesiology (T.K., M.W., M.Mi., K.I., M.Ma., Ta.S., To.S.) and Clinical Pharmacology (M.Y., H.K.) and Education and Research Support Center (K.I.), Tokai University School of Medicine, Kanagawa, Japan.
Miura M; Departments of Anesthesiology (T.K., M.W., M.Mi., K.I., M.Ma., Ta.S., To.S.) and Clinical Pharmacology (M.Y., H.K.) and Education and Research Support Center (K.I.), Tokai University School of Medicine, Kanagawa, Japan.
Ito K; Departments of Anesthesiology (T.K., M.W., M.Mi., K.I., M.Ma., Ta.S., To.S.) and Clinical Pharmacology (M.Y., H.K.) and Education and Research Support Center (K.I.), Tokai University School of Medicine, Kanagawa, Japan.
Matsuda M; Departments of Anesthesiology (T.K., M.W., M.Mi., K.I., M.Ma., Ta.S., To.S.) and Clinical Pharmacology (M.Y., H.K.) and Education and Research Support Center (K.I.), Tokai University School of Medicine, Kanagawa, Japan.
Iwao K; Departments of Anesthesiology (T.K., M.W., M.Mi., K.I., M.Ma., Ta.S., To.S.) and Clinical Pharmacology (M.Y., H.K.) and Education and Research Support Center (K.I.), Tokai University School of Medicine, Kanagawa, Japan.
Kobayashi H; Departments of Anesthesiology (T.K., M.W., M.Mi., K.I., M.Ma., Ta.S., To.S.) and Clinical Pharmacology (M.Y., H.K.) and Education and Research Support Center (K.I.), Tokai University School of Medicine, Kanagawa, Japan.
Suzuki T; Departments of Anesthesiology (T.K., M.W., M.Mi., K.I., M.Ma., Ta.S., To.S.) and Clinical Pharmacology (M.Y., H.K.) and Education and Research Support Center (K.I.), Tokai University School of Medicine, Kanagawa, Japan.
Suzuki T; Departments of Anesthesiology (T.K., M.W., M.Mi., K.I., M.Ma., Ta.S., To.S.) and Clinical Pharmacology (M.Y., H.K.) and Education and Research Support Center (K.I.), Tokai University School of Medicine, Kanagawa, Japan.
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 Oct; Vol. 375 (1), pp. 104-114. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Analgesics/*pharmacology
Enkephalin, Methionine/*pharmacology
Peptides/*pharmacology
Protease Inhibitors/*pharmacology
Vas Deferens/*drug effects
Analgesics/administration & dosage ; Animals ; Dose-Response Relationship, Drug ; Drug Synergism ; Enkephalin, Methionine/administration & dosage ; In Vitro Techniques ; Injections, Spinal ; Male ; Mice ; Mice, Inbred ICR ; Motor Activity/drug effects ; Nociceptive Pain/drug therapy ; Nociceptive Pain/metabolism ; Pain Measurement ; Peptides/administration & dosage ; Protease Inhibitors/administration & dosage ; Protein Binding ; Radioligand Assay ; Rats, Wistar ; Receptors, Opioid/metabolism
Czasopismo naukowe
Tytuł :
Anti-inflammatory and metabolic reprogramming effects of MENK produce antitumor response in CT26 tumor-bearing mice.
Autorzy :
Tuo Y; Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhang Z; Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tian C; Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hu Q; Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xie R; Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yang J; Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhou H; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lu L; Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiang M; Department of Pharmacology, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2020 Jul; Vol. 108 (1), pp. 215-228. Date of Electronic Publication: 2020 Jan 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Antineoplastic Agents/*pharmacology
Colonic Neoplasms/*metabolism
Enkephalin, Methionine/*pharmacology
Animals ; Anti-Inflammatory Agents/therapeutic use ; Antineoplastic Agents/therapeutic use ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/immunology ; Colonic Neoplasms/pathology ; Cyclophosphamide/pharmacology ; Cytokines/metabolism ; Enkephalin, Methionine/therapeutic use ; Glycolipids/metabolism ; Glycolysis/drug effects ; Immunosuppression ; Inflammation/pathology ; Liver/drug effects ; Liver/metabolism ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Myeloid-Derived Suppressor Cells/drug effects ; Myeloid-Derived Suppressor Cells/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain.
Autorzy :
Jimenez-Vargas NN; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON, Canada K7L 2V7.
Gong J; Department of Biomedical Engineering, Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10032.
Wisdom MJ; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010.
Jensen DD; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010.; Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Latorre R; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010.
Hegron A; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010.
Teng S; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010.
DiCello JJ; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Rajasekhar P; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Veldhuis NA; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
Carbone SE; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Yu Y; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON, Canada K7L 2V7.
Lopez-Lopez C; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON, Canada K7L 2V7.
Jaramillo-Polanco J; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON, Canada K7L 2V7.
Canals M; Centre for Membrane Proteins and Receptors and Division of Physiology, Pharmacology, and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, NG7 2RD Nottingham, United Kingdom.
Reed DE; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON, Canada K7L 2V7.
Lomax AE; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON, Canada K7L 2V7.
Schmidt BL; Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Leong KW; Department of Biomedical Engineering, Fu Foundation School of Engineering and Applied Science, Columbia University, New York, NY 10032.
Vanner SJ; Gastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON, Canada K7L 2V7.
Halls ML; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia; .
Bunnett NW; Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010; .
Poole DP; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia; .; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jun 30; Vol. 117 (26), pp. 15281-15292. Date of Electronic Publication: 2020 Jun 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Enkephalin, Leucine-2-Alanine/*pharmacology
Inflammation/*complications
Pain/*drug therapy
Pain/*metabolism
Receptors, Opioid, delta/*agonists
Animals ; Colon/innervation ; Enkephalin, Leucine-2-Alanine/administration & dosage ; HEK293 Cells ; Humans ; Mice ; Nanoparticles/administration & dosage ; Neurons ; Nociceptors/metabolism ; Receptors, Opioid, delta/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Activation of the δ opioid receptor relieves cerebral ischemic injury in rats via EGFR transactivation.
Autorzy :
Chen M; Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Wu S; Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Shen B; Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Fan Q; Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Zhang R; Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Zhou Y; Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Zhang P; Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Wang L; Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China. Electronic address: .
Zhang L; Department of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 May 15; Vol. 273, pp. 119292. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Transcriptional Activation*
Brain Ischemia/*prevention & control
Enkephalin, Leucine-2-Alanine/*pharmacology
ErbB Receptors/*metabolism
Infarction, Middle Cerebral Artery/*complications
Receptors, Opioid, delta/*agonists
Reperfusion Injury/*prevention & control
Animals ; Apoptosis ; Brain Ischemia/etiology ; Brain Ischemia/metabolism ; Brain Ischemia/pathology ; ErbB Receptors/genetics ; Male ; Phosphorylation ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/etiology ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology
Czasopismo naukowe
Tytuł :
Energy Landscape Mapping and Replica Exchange Molecular Dynamics of an Adsorbed Peptide.
Autorzy :
Ross-Naylor JA; School of Chemical Engineering, The University of Adelaide, Adelaide, South Australia 5005, Australia.
Mijajlovic M; School of Engineering, Newcastle University, Newcastle upon Tyne NE1 7RU, United Kingdom.
Biggs MJ; College of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom.
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Źródło :
The journal of physical chemistry. B [J Phys Chem B] 2020 Apr 02; Vol. 124 (13), pp. 2527-2538. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enkephalin, Methionine*
Molecular Dynamics Simulation*
Adsorption ; Entropy ; Molecular Conformation
Czasopismo naukowe
Tytuł :
Methionine enkephalin inhibits influenza A virus infection through upregulating antiviral state in RAW264.7 cells.
Autorzy :
Tian J; Department of Immunology, School of Basic Medical Science, Jinzhou Medical University, Jinzhou 121001, China; Department of Immunology, School of Basic Medical Science, China Medical University, Shenyang 110122, China.
Qu N; Department of Gynecology, Cancer Hospital, China Medical University, Shenyang 110042, China.
Jiao X; Department of Translational Medicine, No.4 Teaching Hospital, China Medical University, Shenyang 110032, China.
Wang X; Department of Immunology, School of Basic Medical Science, China Medical University, Shenyang 110122, China.
Geng J; Department of Ophthalmology, No.1 Teaching Hospital, China Medical University, Shenyang 110001, China.
Griffin N; Immune Therapeutics, Inc., 37 North Orange Avenue, Suite 607, Orlando, FL 32801, USA.
Shan F; Department of Immunology, School of Basic Medical Science, China Medical University, Shenyang 110122, China. Electronic address: .
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2020 Jan; Vol. 78, pp. 106032. Date of Electronic Publication: 2019 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
Adjuvants, Immunologic/*pharmacology
Enkephalin, Methionine/*pharmacology
Influenza A Virus, H1N1 Subtype/*immunology
Influenza, Human/*drug therapy
Macrophages/*drug effects
Adjuvants, Immunologic/therapeutic use ; Animals ; Enkephalin, Methionine/therapeutic use ; Humans ; Influenza, Human/immunology ; Influenza, Human/virology ; Interferon-beta/metabolism ; Interleukin-6/metabolism ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; RAW 264.7 Cells ; Receptors, Opioid, mu/metabolism ; Signal Transduction/drug effects ; Signal Transduction/immunology ; Transcription Factor RelA/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Up-Regulation/drug effects ; Virus Replication/drug effects ; Virus Replication/immunology
Czasopismo naukowe
Tytuł :
The Meta-Position of Phe in Leu-Enkephalin Regulates Potency, Selectivity, Functional Activity, and Signaling Bias at the Delta and Mu Opioid Receptors.
Autorzy :
Cassell RJ; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Sharma KK; Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS 66045, USA.
Su H; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Cummins BR; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Cui H; College of Wuya, Shenyang Pharmaceutical University, Shenyang 110016, China.
Mores KL; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Blaine AT; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Altman RA; Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS 66045, USA.
van Rijn RM; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.; Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2019 Dec 12; Vol. 24 (24). Date of Electronic Publication: 2019 Dec 12.
Typ publikacji :
Journal Article
MeSH Terms :
Enkephalin, Leucine/*pharmacology
Receptors, Opioid, delta/*metabolism
Receptors, Opioid, mu/*metabolism
Signal Transduction/*drug effects
Animals ; CHO Cells ; Cricetulus ; Enkephalin, Leucine/genetics ; Humans ; Phenylalanine ; Receptors, Opioid, delta/agonists ; Receptors, Opioid, delta/genetics ; Receptors, Opioid, mu/agonists ; Receptors, Opioid, mu/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Opioid Growth Factor and its Derivatives as Potential Non-toxic Multifunctional Anticancer and Analgesic Compounds.
Autorzy :
Budka J; Department of Medical Chemistry, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Kowalski S; Department of Medical Chemistry, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Chylinska M; Department of Medical Chemistry, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Dzierzbicka K; Department of Organic Chemistry, Faculty of Chemistry, Gdansk University of Technology, Gdansk, Poland.
Inkielewicz-Stepniak I; Department of Medical Chemistry, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
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Źródło :
Current medicinal chemistry [Curr Med Chem] 2021; Vol. 28 (4), pp. 673-686.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Analgesics, Opioid*/pharmacology
Antineoplastic Agents*/pharmacology
Analgesics/pharmacology ; Analgesics/therapeutic use ; Enkephalin, Methionine ; Humans ; Intercellular Signaling Peptides and Proteins ; Quality of Life
Czasopismo naukowe
Tytuł :
Modulation of μ-opioid receptor activation by acidic pH is dependent on ligand structure and an ionizable amino acid residue.
Autorzy :
Meyer J; Department of Experimental Anesthesiology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Germany.
Del Vecchio G; Department of Experimental Anesthesiology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Germany.
Seitz V; Department of Experimental Anesthesiology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Germany.
Massaly N; Department of Experimental Anesthesiology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Germany.
Stein C; Department of Experimental Anesthesiology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Germany.
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2019 Dec; Vol. 176 (23), pp. 4510-4520. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article
MeSH Terms :
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/*pharmacology
Fentanyl/*pharmacology
Histamine/*metabolism
Naloxone/*pharmacology
Receptors, Opioid, mu/*antagonists & inhibitors
Cells, Cultured ; Dose-Response Relationship, Drug ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/chemistry ; Fentanyl/chemistry ; HEK293 Cells ; Histamine/genetics ; Humans ; Hydrogen-Ion Concentration ; Ligands ; Molecular Structure ; Mutation ; Naloxone/chemistry ; Receptors, Opioid, mu/genetics ; Receptors, Opioid, mu/metabolism ; Signal Transduction/drug effects ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs.
Autorzy :
Harris HM; University of Florida Department of Pharmacodynamics, Gainesville, FL, USA.
Eans SO; University of Florida Department of Pharmacodynamics, Gainesville, FL, USA.
Ganno ML; Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL, USA. .
Davis JC; Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL, USA. .
Dooley CT; Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL, USA. .
McLaughlin JP; University of Florida Department of Pharmacodynamics, Gainesville, FL, USA.
Nefzi A; Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL, USA. .
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Źródło :
Organic & biomolecular chemistry [Org Biomol Chem] 2019 Jun 07; Vol. 17 (21), pp. 5305-5315. Date of Electronic Publication: 2019 May 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Analgesics, Opioid/*pharmacology
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/*pharmacology
Enkephalin, Methionine/*pharmacology
Receptors, Opioid/*agonists
Thiazoles/*pharmacology
Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/chemistry ; Animals ; Cyclization ; Dose-Response Relationship, Drug ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/administration & dosage ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/chemistry ; Enkephalin, Methionine/administration & dosage ; Enkephalin, Methionine/chemistry ; Injections, Intraventricular ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Conformation ; Respiratory Rate ; Thiazoles/administration & dosage ; Thiazoles/chemistry
Czasopismo naukowe
Tytuł :
Interaction of opioid growth factor (OGF) and opioid antagonist and their significance in cancer therapy.
Autorzy :
Wang R; Department of Gynecology, No.1 Teaching Hospital, China Medical University, Shenyang 110001, China.
Zhang Y; Department of Gynecology, No.1 Teaching Hospital, China Medical University, Shenyang 110001, China. Electronic address: .
Shan F; Department of immunology, School of Basic Medical Science, China Medical University, Shenyang, 110122, China. Electronic address: .
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2019 Oct; Vol. 75, pp. 105785. Date of Electronic Publication: 2019 Aug 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Enkephalin, Methionine/*therapeutic use
Naltrexone/*therapeutic use
Narcotic Antagonists/*therapeutic use
Neoplasms/*drug therapy
Animals ; Enkephalin, Methionine/pharmacology ; Humans ; Naltrexone/pharmacology ; Narcotic Antagonists/pharmacology ; Neoplasms/immunology ; Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Plasma metabolites were associated with spatial working memory in major depressive disorder.
Autorzy :
Du Y; Psychiatric Laboratory and Mental Health Center.
Wei J; Psychiatric Laboratory and Mental Health Center.; West China Brain Research Center, West China Hospital of Sichuan University, Chengdu.
Yang X; Psychiatric Laboratory and Mental Health Center.
Dou Y; Psychiatric Laboratory and Mental Health Center.
Zhao L; Psychiatric Laboratory and Mental Health Center.; West China Brain Research Center, West China Hospital of Sichuan University, Chengdu.
Qi X; Psychiatric Laboratory and Mental Health Center.
Yu X; Psychiatric Laboratory and Mental Health Center.
Guo W; Psychiatric Laboratory and Mental Health Center.; West China Brain Research Center, West China Hospital of Sichuan University, Chengdu.
Wang Q; Psychiatric Laboratory and Mental Health Center.; West China Brain Research Center, West China Hospital of Sichuan University, Chengdu.
Deng W; Psychiatric Laboratory and Mental Health Center.; West China Brain Research Center, West China Hospital of Sichuan University, Chengdu.
Li M; Psychiatric Laboratory and Mental Health Center.; West China Brain Research Center, West China Hospital of Sichuan University, Chengdu.
Lin D; College of Foreign Languages and Cultures, Sichuan University, PR China.
Li T; Psychiatric Laboratory and Mental Health Center.; West China Brain Research Center, West China Hospital of Sichuan University, Chengdu.
Ma X; Psychiatric Laboratory and Mental Health Center.; West China Brain Research Center, West China Hospital of Sichuan University, Chengdu.
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Feb 26; Vol. 100 (8), pp. e24581.
Typ publikacji :
Journal Article
MeSH Terms :
Depressive Disorder, Major/*blood
Memory, Short-Term/*physiology
Spatial Navigation/*physiology
Adolescent ; Adult ; Age Factors ; Algorithms ; Body Mass Index ; Chromatography, Liquid ; Depressive Disorder, Major/physiopathology ; Dipeptides/blood ; Enkephalin, Leucine/blood ; Female ; Humans ; Male ; Metabolomics ; Middle Aged ; Pentanoic Acids/blood ; Psychiatric Status Rating Scales ; Sex Factors ; Tandem Mass Spectrometry ; Young Adult
Czasopismo naukowe
Tytuł :
Sex differences in μ-opioid regulation of coerulear-cortical transmission.
Autorzy :
Guajardo HM; Neuroscience Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. Electronic address: .
Valentino RJ; Neuroscience Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
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Źródło :
Neuroscience letters [Neurosci Lett] 2021 Feb 16; Vol. 746, pp. 135651. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Sex Characteristics*
Analgesics, Opioid/*administration & dosage
Locus Coeruleus/*metabolism
Prefrontal Cortex/*metabolism
Receptors, Opioid, mu/*metabolism
Animals ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/administration & dosage ; Female ; Locus Coeruleus/drug effects ; Male ; Microinjections/methods ; Prefrontal Cortex/drug effects ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid, mu/agonists ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology
Czasopismo naukowe
Tytuł :
Endogenous Opioid Signaling in the Mouse Retina Modulates Pupillary Light Reflex.
Autorzy :
Cleymaet AM; Department of Biomedical Sciences, Colorado State University, Ft. Collins, CO 80523, USA.; Department of Clinical Sciences, Colorado State University, Ft. Collins, CO 80523, USA.
Berezin CT; Cellular and Molecular Biology Graduate Program, Colorado State University, Ft. Collins, CO 80523, USA.
Vigh J; Department of Biomedical Sciences, Colorado State University, Ft. Collins, CO 80523, USA.; Cellular and Molecular Biology Graduate Program, Colorado State University, Ft. Collins, CO 80523, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 08; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article
MeSH Terms :
Opioid Peptides/*genetics
Receptors, Opioid, mu/*genetics
Retina/*metabolism
Visual Perception/*genetics
Animals ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/pharmacology ; Enkephalins/antagonists & inhibitors ; Enkephalins/genetics ; Humans ; Light ; Mice ; Peptides/pharmacology ; Receptors, Opioid/genetics ; Receptors, Opioid, mu/antagonists & inhibitors ; Reflex/genetics ; Retina/pathology ; Retinal Ganglion Cells/metabolism ; Retinal Ganglion Cells/physiology ; Signal Transduction/drug effects ; Visual Perception/drug effects ; beta-Endorphin/genetics
Czasopismo naukowe
Tytuł :
Differential effects of novel kappa opioid receptor antagonists on dopamine neurons using acute brain slice electrophysiology.
Autorzy :
Margolis EB; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States of America.
Wallace TL; BlackThorn Therapeutics, San Francisco, CA, United States of America.
Van Orden LJ; BlackThorn Therapeutics, San Francisco, CA, United States of America.
Martin WJ; BlackThorn Therapeutics, San Francisco, CA, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Dec 29; Vol. 15 (12), pp. e0232864. Date of Electronic Publication: 2020 Dec 29 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopaminergic Neurons/*drug effects
Membrane Potentials/*drug effects
Receptors, Opioid, kappa/*antagonists & inhibitors
Analgesics, Opioid/pharmacology ; Animals ; Benzamides/pharmacology ; Biphenyl Compounds/pharmacology ; Dopaminergic Neurons/metabolism ; Electrophysiology ; Enkephalin, D-Penicillamine (2,5)-/pharmacology ; Male ; Mesencephalon/metabolism ; Narcotic Antagonists/pharmacology ; Oxadiazoles/pharmacology ; Patch-Clamp Techniques/methods ; Piperidines/pharmacology ; Pyrrolidines/pharmacology ; Quinolines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid, kappa/metabolism ; Receptors, Opioid, mu/metabolism ; Sulfonamides/pharmacology ; Ventral Tegmental Area/drug effects
Czasopismo naukowe
Tytuł :
Positive allosteric modulation of the cannabinoid type-1 receptor (CB1R) in periaqueductal gray (PAG) antagonizes anti-nociceptive and cellular effects of a mu-opioid receptor agonist in morphine-withdrawn rats.
Autorzy :
Datta U; Department of Physiology, Louisiana State University Health Science Center, Room 7205 1901 Perdido Street, New Orleans, LA, 70112, USA.; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Kelley LK; Department of Physiology, Louisiana State University Health Science Center, Room 7205 1901 Perdido Street, New Orleans, LA, 70112, USA.
Middleton JW; Department of Cell Biology & Anatomy, Louisiana State University Health Science Center, New Orleans, LA, 70112, USA.; Neuroscience Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA, 70112, USA.; Alcohol & Drug Abuse Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA, 70112, USA.
Gilpin NW; Department of Physiology, Louisiana State University Health Science Center, Room 7205 1901 Perdido Street, New Orleans, LA, 70112, USA. .; Neuroscience Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA, 70112, USA. .; Alcohol & Drug Abuse Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA, 70112, USA. .; U.S. Department of Veterans Affairs, Biomedical Laboratory Research and Development Service, Washington, DC, USA. .
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2020 Dec; Vol. 237 (12), pp. 3729-3739. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article
MeSH Terms :
Analgesics, Opioid/*adverse effects
Morphine/*adverse effects
Nociception/*drug effects
Periaqueductal Gray/*drug effects
Receptor, Cannabinoid, CB1/*physiology
Receptors, Opioid, mu/*agonists
Substance Withdrawal Syndrome/*physiopathology
Allosteric Regulation/drug effects ; Allosteric Regulation/physiology ; Analgesics, Opioid/administration & dosage ; Animals ; Cannabinoid Receptor Agonists/administration & dosage ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/administration & dosage ; Hyperalgesia/chemically induced ; Hyperalgesia/drug therapy ; Hyperalgesia/metabolism ; Male ; Microinjections/methods ; Morphine/administration & dosage ; Nociception/physiology ; Periaqueductal Gray/metabolism ; Rats ; Rats, Wistar ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptors, Opioid, mu/metabolism ; Substance Withdrawal Syndrome/drug therapy
Czasopismo naukowe
Tytuł :
Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors.
Autorzy :
Möller J; Max Delbrück Center for Molecular Medicine, Berlin, Germany.; Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany.
Isbilir A; Max Delbrück Center for Molecular Medicine, Berlin, Germany.; Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany.
Sungkaworn T; Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany.; Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan, Thailand.
Osberg B; Max Delbrück Center for Molecular Medicine, Berlin, Germany.; Max Delbrück Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Bioinformatics and Omics Data Science Platform, Berlin, Germany.
Karathanasis C; Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Frankfurt, Germany.
Sunkara V; Zuse Institute Berlin, Berlin, Germany.
Grushevskyi EO; Max Delbrück Center for Molecular Medicine, Berlin, Germany.; Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany.
Bock A; Max Delbrück Center for Molecular Medicine, Berlin, Germany.; Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany.
Annibale P; Max Delbrück Center for Molecular Medicine, Berlin, Germany.; Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany.
Heilemann M; Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Frankfurt, Germany.
Schütte C; Zuse Institute Berlin, Berlin, Germany.; Free University of Berlin, Berlin, Germany.
Lohse MJ; Max Delbrück Center for Molecular Medicine, Berlin, Germany. .; Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany. .; Free University of Berlin, Berlin, Germany. .; ISAR Bioscience Institute, Munich/Planegg, Germany. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2020 Sep; Vol. 16 (9), pp. 946-954. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Opioid, mu/*agonists
Receptors, Opioid, mu/*metabolism
Single Molecule Imaging/*methods
Animals ; CHO Cells ; Cricetulus ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/chemistry ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/pharmacology ; Fluorescence Resonance Energy Transfer ; Morphine/chemistry ; Morphine/pharmacology ; Mutation ; Naloxone/chemistry ; Naloxone/pharmacology ; Naltrexone/analogs & derivatives ; Naltrexone/chemistry ; Naltrexone/pharmacology ; Narcotic Antagonists/chemistry ; Narcotic Antagonists/pharmacology ; Phosphorylation ; Protein Multimerization ; Receptors, Opioid, mu/antagonists & inhibitors ; Receptors, Opioid, mu/genetics ; beta-Arrestins/metabolism
Czasopismo naukowe

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