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Tytuł :
In vitro characterization of the furin inhibitor MI-1851: Albumin binding, interaction with cytochrome P450 enzymes and cytotoxicity.
Autorzy :
Pászti-Gere E; Department of Pharmacology and Toxicology, University of Veterinary Medicine, Budapest, Hungary. Electronic address: .
Szentkirályi-Tóth A; Department of Pharmacology and Toxicology, University of Veterinary Medicine, Budapest, Hungary.
Szabó P; MS Metabolomics Laboratory, Center for Structural Study, Research Center for Natural Sciences, Budapest, Hungary.
Steinmetzer T; Faculty of Pharmacy, Institute of Pharmaceutical Chemistry, Philipps University Marburg, Marburg, Germany.
Fliszár-Nyúl E; Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Pécs, Hungary.
Poór M; Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Pécs, Hungary; Lab-on-a-Chip Research Group, János Szentágothai Research Centre, University of Pécs, Pécs, Hungary. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Jul; Vol. 151, pp. 113124. Date of Electronic Publication: 2022 May 17.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 Enzyme Inhibitors*/metabolism
Cytochrome P-450 Enzyme Inhibitors*/pharmacology
Cytochrome P-450 Enzyme Inhibitors*/toxicity
Furin*/antagonists & inhibitors
Furin*/metabolism
Furin*/pharmacology
Albumins/pharmacology ; COVID-19/drug therapy ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P-450 Enzyme System/drug effects ; Cytochrome P-450 Enzyme System/metabolism ; Humans ; Microsomes, Liver ; SARS-CoV-2/drug effects ; Serum Albumin, Human/metabolism ; Spike Glycoprotein, Coronavirus
Czasopismo naukowe
Tytuł :
Ru(II) photocages enable precise control over enzyme activity with red light.
Autorzy :
Havrylyuk D; Department of Chemistry, University of Kentucky, Lexington, KY, 40506, USA.
Hachey AC; Department of Chemistry, University of Kentucky, Lexington, KY, 40506, USA.
Fenton A; Department of Chemistry, University of Kentucky, Lexington, KY, 40506, USA.
Heidary DK; Department of Chemistry, University of Kentucky, Lexington, KY, 40506, USA. .
Glazer EC; Department of Chemistry, University of Kentucky, Lexington, KY, 40506, USA. .
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Źródło :
Nature communications [Nat Commun] 2022 Jun 25; Vol. 13 (1), pp. 3636. Date of Electronic Publication: 2022 Jun 25.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 Enzyme System*/genetics
Cytochrome P-450 Enzyme System*/metabolism
Neoplasms*
Cytochrome P-450 CYP1B1/genetics ; Drug Interactions ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Humans ; Ruthenium
Czasopismo naukowe
Tytuł :
Angiotensin II Promotes SARS-CoV-2 Infection via Upregulation of ACE2 in Human Bronchial Cells.
Autorzy :
Caputo I; Specialized Center for Blood Pressure Disorders-Regione Veneto and Internal Emergency Medicine Unit, Department of Medicine-DIMED, University of Padua, 35128 Padua, Italy.
Caroccia B; Specialized Center for Blood Pressure Disorders-Regione Veneto and Internal Emergency Medicine Unit, Department of Medicine-DIMED, University of Padua, 35128 Padua, Italy.
Frasson I; Department of Molecular Medicine-DMM, University of Padua, 35121 Padua, Italy.
Poggio E; Department of Biology, University of Padua, 35131 Padua, Italy.
Zamberlan S; Specialized Center for Blood Pressure Disorders-Regione Veneto and Internal Emergency Medicine Unit, Department of Medicine-DIMED, University of Padua, 35128 Padua, Italy.
Morpurgo M; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, 35131 Padua, Italy.
Seccia TM; Specialized Center for Blood Pressure Disorders-Regione Veneto and Internal Emergency Medicine Unit, Department of Medicine-DIMED, University of Padua, 35128 Padua, Italy.
Calì T; Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy.
Brini M; Department of Biology, University of Padua, 35131 Padua, Italy.
Richter SN; Department of Molecular Medicine-DMM, University of Padua, 35121 Padua, Italy.
Rossi GP; Specialized Center for Blood Pressure Disorders-Regione Veneto and Internal Emergency Medicine Unit, Department of Medicine-DIMED, University of Padua, 35128 Padua, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2022 May 04; Vol. 23 (9). Date of Electronic Publication: 2022 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2*/genetics
COVID-19*
Angiotensin II/metabolism ; Angiotensin II/pharmacology ; Angiotensin Receptor Antagonists/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Humans ; Receptor, Angiotensin, Type 1/genetics ; Receptor, Angiotensin, Type 1/metabolism ; Renin-Angiotensin System ; SARS-CoV-2 ; Up-Regulation
Czasopismo naukowe
Tytuł :
SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesis.
Autorzy :
Qin C; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.
Rao Y; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.
Yuan H; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.; Department of Chemistry, Dornsife College of Arts, Letters and Sciences, University of Southern California, Los Angeles, CA 90089.
Wang TY; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.
Zhao J; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.; Florida Research and Innovation Center, Cleveland Clinic, Port St. Lucie, FL 34987.
Espinosa B; Department of Chemistry, Dornsife College of Arts, Letters and Sciences, University of Southern California, Los Angeles, CA 90089.
Liu Y; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.
Zhang S; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.
Savas AC; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.
Liu Q; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.
Zarinfar M; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.
Rice S; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.
Henley J; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.
Comai L; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.
Graham NA; Mork Family Department of Chemical Engineering and Materials Science, Norris Comprehensive Cancer Center, Los Angeles, CA 90089.
Chen C; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.
Zhang C; Department of Chemistry, Dornsife College of Arts, Letters and Sciences, University of Southern California, Los Angeles, CA 90089.
Feng P; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Jun 28; Vol. 119 (26), pp. e2122897119. Date of Electronic Publication: 2022 Jun 14.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents*/pharmacology
Antiviral Agents*/therapeutic use
Aspartate Carbamoyltransferase*/antagonists & inhibitors
COVID-19*/drug therapy
Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)*/antagonists & inhibitors
Dihydroorotase*/antagonists & inhibitors
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/therapeutic use
Pyrimidines*/antagonists & inhibitors
Pyrimidines*/biosynthesis
SARS-CoV-2*/drug effects
SARS-CoV-2*/physiology
Virus Replication*/drug effects
Animals ; Enzyme Activation/drug effects ; Humans ; Inflammation/drug therapy ; Mice ; RNA-Binding Proteins/metabolism ; Transcription Factor RelA/metabolism ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Long-term eliglustat treatment of Gaucher patients over up to 10 years in Vienna.
Autorzy :
Stulnig TM; Department of Medicine III and Karl Landsteiner Institute for Metabolic Diseases and Nephrology, Clinic Hietzing, Vienna Health Care Group, Wolkersbergenstr. 1, 1130, Vienna, Austria. .
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Źródło :
Wiener klinische Wochenschrift [Wien Klin Wochenschr] 2022 Jun; Vol. 134 (11-12), pp. 471-477. Date of Electronic Publication: 2022 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Inhibitors*/adverse effects
Enzyme Inhibitors*/therapeutic use
Gaucher Disease*/drug therapy
Enzyme Replacement Therapy ; Humans ; Pyrrolidines/adverse effects ; Pyrrolidines/therapeutic use
Czasopismo naukowe
Tytuł :
Thymosin-α1 binds with ACE and downregulates the expression of ACE2 in human respiratory epithelia.
Autorzy :
Zhang YH; Institute of Clinical Pharmacology, Peking University First Hospital, 100191 Beijing, China.; Department of Pharmacy, Peking University First Hospital, 100034 Beijing, China.
Wang WY; School of Basic Medical Sciences, Capital Medical University, 100069 Beijing, China.
Pang XC; Institute of Clinical Pharmacology, Peking University First Hospital, 100191 Beijing, China.; Department of Pharmacy, Peking University First Hospital, 100034 Beijing, China.
Wang Z; Department of Cardiology, Xuanwu Hospital, Capital Medical University, 100053 Beijing, China.
Wang CZ; School of Basic Medical Sciences, Capital Medical University, 100069 Beijing, China.
Zhou H; School of Basic Medical Sciences, Capital Medical University, 100069 Beijing, China.
Zheng B; Institute of Clinical Pharmacology, Peking University First Hospital, 100191 Beijing, China.; Department of Pharmacy, Peking University First Hospital, 100034 Beijing, China.
Cui YM; Institute of Clinical Pharmacology, Peking University First Hospital, 100191 Beijing, China.; Department of Pharmacy, Peking University First Hospital, 100034 Beijing, China.
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Źródło :
Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2022 Feb 11; Vol. 27 (2), pp. 48.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2*
COVID-19*/drug therapy
Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Humans ; SARS-CoV-2 ; Thymalfasin/pharmacology
Czasopismo naukowe
Tytuł :
Use In Silico and In Vitro Methods to Screen Hepatotoxic Chemicals and CYP450 Enzyme Inhibitors.
Autorzy :
Liu Y; Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2474, pp. 189-198.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 Enzyme Inhibitors*
Enzyme Inhibitors*/chemistry
Quantitative Structure-Activity Relationship*
Animals ; Cytochrome P-450 Enzyme System/chemistry ; Humans ; Liver
Czasopismo naukowe
Tytuł :
COVID-19, Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Inhibition: Implications for Practice.
Autorzy :
Katsi V; 1st Department of Cardiology, 'Hippokration' General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
Pavlidis G; Emergency Department, 'Hippokration' General Hospital, Athens, Greece.
Charalambous G; Emergency Department, 'Hippokration' General Hospital, Athens, Greece.
Tousoulis D; 1st Department of Cardiology, 'Hippokration' General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
Toutouzas K; 1st Department of Cardiology, 'Hippokration' General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
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Źródło :
Current hypertension reviews [Curr Hypertens Rev] 2022; Vol. 18 (1), pp. 3-10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Angiotensin-Converting Enzyme 2*
COVID-19*/drug therapy
Angiotensin Receptor Antagonists/adverse effects ; Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Humans ; Renin-Angiotensin System ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Ibuprofen, Flurbiprofen, Etoricoxib or Paracetamol Do Not Influence ACE2 Expression and Activity In Vitro or in Mice and Do Not Exacerbate In-Vitro SARS-CoV-2 Infection.
Autorzy :
de Bruin N; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.; Fraunhofer Cluster of Excellence Immune Mediated Diseases, CIMD, 60596 Frankfurt am Main, Germany.
Schneider AK; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Reus P; Institute of Medical Virology, University Hospital Frankfurt/Main, Goethe University, Paul-Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany.
Talmon S; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Ciesek S; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.; Institute of Medical Virology, University Hospital Frankfurt/Main, Goethe University, Paul-Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany.
Bojkova D; Institute of Medical Virology, University Hospital Frankfurt/Main, Goethe University, Paul-Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany.
Cinatl J; Institute of Medical Virology, University Hospital Frankfurt/Main, Goethe University, Paul-Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany.
Lodhi I; Reckitt Healthcare Ltd., Dansom Lane South, Kingston Upon Hull HU8 7DS, UK.
Charlesworth B; Reckitt Healthcare Ltd., Dansom Lane South, Kingston Upon Hull HU8 7DS, UK.
Sinclair S; Reckitt Healthcare Ltd., Dansom Lane South, Kingston Upon Hull HU8 7DS, UK.
Pennick G; Reckitt Healthcare Ltd., Dansom Lane South, Kingston Upon Hull HU8 7DS, UK.
Laughey WF; Reckitt Healthcare Ltd., Dansom Lane South, Kingston Upon Hull HU8 7DS, UK.; Health Professions Education Unit, Hull York Medical School, University of York, Heslington, York YO10 5DD, UK.
Gribbon P; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, 22525 Hamburg, Germany.
Kannt A; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.; Fraunhofer Cluster of Excellence Immune Mediated Diseases, CIMD, 60596 Frankfurt am Main, Germany.
Schiffmann S; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.; Pharmazentrum Frankfurt/ZAFES, Department of Clinical Pharmacology, Goethe-University Hospital Frankfurt am Main, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 19; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 19.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme 2*/genetics
Angiotensin-Converting Enzyme 2*/metabolism
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
COVID-19/*genetics
Acetaminophen/pharmacology ; Animals ; COVID-19/metabolism ; COVID-19/pathology ; Caco-2 Cells ; Disease Progression ; Enzyme Activation/drug effects ; Etoricoxib/pharmacology ; Flurbiprofen/pharmacology ; Gene Expression Regulation, Enzymologic/drug effects ; Humans ; Ibuprofen/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions.
Autorzy :
Nasrin S; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington.
Watson CJW; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington.
Perez-Paramo YX; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington.
Lazarus P; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington .
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Źródło :
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2021 Dec; Vol. 49 (12), pp. 1070-1080. Date of Electronic Publication: 2021 Sep 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cannabinoids*/classification
Cannabinoids*/metabolism
Cannabis*
Cytochrome P-450 Enzyme System*/analysis
Cytochrome P-450 Enzyme System*/classification
Cannabidiol/*metabolism
Cannabinol/*metabolism
Dronabinol/*analogs & derivatives
Drug Interactions/*physiology
Biotransformation ; Cytochrome P-450 Enzyme Inhibitors/pharmacokinetics ; Dronabinol/metabolism ; Glucuronosyltransferase/metabolism ; HEK293 Cells ; Hepatobiliary Elimination/drug effects ; Humans
Czasopismo naukowe
Tytuł :
No influence of spironolactone on plasma concentrations of angiotensin-converting enzyme 2: Findings from the HOMAGE randomized trial.
Autorzy :
Ferreira JP; Inserm U1116, CHRU, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), centre d'investigations cliniques-plurithématique 1433, Nancy, France; Unidade de Investigaçao Cardiovascular-UnIC, Faculdade de Medicina Universidade do Porto, Porto, Portugal. Electronic address: .
Girerd N; Inserm U1116, CHRU, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), centre d'investigations cliniques-plurithématique 1433, Nancy, France.
Rocca HB; Department of Cardiology, Maastricht University, Maastricht, Netherlands.
Pellicori P; Clinical Trials Unit, Robertson Institute of Biostatistics, University of Glasgow, University Avenue, Glasgow, UK.
Cleland JG; Clinical Trials Unit, Robertson Institute of Biostatistics, University of Glasgow, University Avenue, Glasgow, UK.
Rossignol P; Inserm U1116, CHRU, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), centre d'investigations cliniques-plurithématique 1433, Nancy, France.
Zannad F; Inserm U1116, CHRU, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), centre d'investigations cliniques-plurithématique 1433, Nancy, France.
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Źródło :
Archives of cardiovascular diseases [Arch Cardiovasc Dis] 2021 Dec; Vol. 114 (12), pp. 814-817. Date of Electronic Publication: 2021 Nov 09.
Typ publikacji :
Letter; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2*
Spironolactone*/adverse effects
Angiotensin-Converting Enzyme Inhibitors ; Humans ; Peptidyl-Dipeptidase A ; Renin-Angiotensin System
Raport
Tytuł :
Comprehensive Approach of F Nuclear Magnetic Resonance, Enzymatic, and In Silico Methods for Site-Specific Hit Selection and Validation of Fragment Molecules that Inhibit Methionine γ-Lyase Activity.
Autorzy :
Ikeda K; Division of Physics for Life Functions, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan.
Kezuka Y; Division of Structural Biology, Department of Pharmaceutical Sciences, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate 028-3694, Japan.
Nonaka T; Division of Structural Biology, Department of Pharmaceutical Sciences, School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate 028-3694, Japan.
Yonezawa T; Division of Physics for Life Functions, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan.
Osawa M; Division of Physics for Life Functions, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan.
Katoh E; Research Center for Advanced Analysis, National Agriculture and Food Research Organization, 2-1-2 Kannondai, Tsukuba, Ibaraki 305-0856, Japan.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Oct 14; Vol. 64 (19), pp. 14299-14310. Date of Electronic Publication: 2021 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Assays*
Carbon-Sulfur Lyases/*antagonists & inhibitors
Enzyme Inhibitors/*chemistry
Nuclear Magnetic Resonance, Biomolecular/*methods
Small Molecule Libraries/*chemistry
Computer Simulation ; Enzyme Inhibitors/pharmacology ; Fluorine ; Ligands ; Small Molecule Libraries/pharmacology
Czasopismo naukowe
Tytuł :
Cytochrome b5 Binds Tightly to Several Human Cytochrome P450 Enzymes.
Autorzy :
Kim D; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146 (D.K., Y.T., F.P.G.), and Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea (D.K., V.K.).
Kim V; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146 (D.K., Y.T., F.P.G.), and Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea (D.K., V.K.).
Tateishi Y; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146 (D.K., Y.T., F.P.G.), and Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea (D.K., V.K.).
Guengerich FP; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146 (D.K., Y.T., F.P.G.), and Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea (D.K., V.K.) .
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Źródło :
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2021 Oct; Vol. 49 (10), pp. 902-909. Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cytochrome P-450 Enzyme System*/classification
Cytochrome P-450 Enzyme System*/metabolism
Cytochrome P-450 CYP3A/*metabolism
Cytochromes b5/*metabolism
Fluoresceins/*pharmacokinetics
NADPH-Ferrihemoprotein Reductase/*metabolism
Sulfonic Acids/*pharmacokinetics
Binding Sites/drug effects ; Binding Sites/physiology ; Cytochrome P-450 Enzyme Inhibitors/pharmacokinetics ; Cytochrome-B(5) Reductase/metabolism ; Endoplasmic Reticulum/metabolism ; Fluorescent Dyes/pharmacokinetics ; Humans ; Microsomes, Liver/metabolism ; Radioligand Assay/methods
Czasopismo naukowe
Tytuł :
Risk Factors for Angiotension-Converting Enzyme Inhibitor-Associated Cough.
Autorzy :
Cimolai N; Faculty of Medicine, The University of British Columbia and Children's and Women's Health Centre of British Columbia, Vancouver, British Columbia, Canada.
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Źródło :
Journal of clinical pharmacology [J Clin Pharmacol] 2021 Sep; Vol. 61 (9), pp. 1251-1252. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji :
Letter; Comment
MeSH Terms :
Angiotensin-Converting Enzyme Inhibitors*
Cough*/chemically induced
Cough*/drug therapy
Enzyme Inhibitors ; Humans ; Risk Factors
Opinia redakcyjna
Tytuł :
Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial.
Autorzy :
Bauer A; Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: .
Schreinlechner M; Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
Sappler N; Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
Dolejsi T; Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
Tilg H; Department of Internal Medicine I, Gastroenterology, Hepatology, and Endocrinology, Medical University of Innsbruck, Innsbruck, Austria.
Aulinger BA; Medizinische Klinik und Poliklinik II, LMU University Hospital Munich, Munich, Germany.
Weiss G; Department of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology and Pneumology, Medical University of Innsbruck, Innsbruck, Austria.
Bellmann-Weiler R; Department of Internal Medicine II, Infectious Diseases, Immunology, Rheumatology and Pneumology, Medical University of Innsbruck, Innsbruck, Austria.
Adolf C; Medizinische Klinik und Poliklinik IV, LMU University Hospital Munich, Munich, Germany.
Wolf D; Department of Internal Medicine V, Hematology and Oncology, Medical University of Innsbruck, Innsbruck, Austria.
Pirklbauer M; Department of Internal Medicine IV, Nephrology and Hypertension, Medical University of Innsbruck, Innsbruck, Austria.
Graziadei I; Department of Internal Medicine, Hospital Hall in Tirol, Hall in Tirol, Austria.
Gänzer H; Department of Internal Medicine, Hospital Schwaz, Schwaz, Austria.
von Bary C; Department of Internal Medicine I, Rotkreuzklinikum Munich, Munich, Germany.
May AE; Department of Internal Medicine, Hospital Memmingen, Memmingen, Germany.
Wöll E; Department of Internal Medicine, Hospital Zams, Zams, Austria.
von Scheidt W; Department of Internal Medicine I, University Hospital Augsburg, Augsburg, Germany.
Rassaf T; Department of Cardiology and Vascular Medicine, West German Heart- and Vascular Center, University Duisburg-Essen, Essen, Germany.
Duerschmied D; University Heart Center Freiburg, Department of Cardiology and Angiology I, University of Freiburg, Freiburg, Germany.
Brenner C; Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
Kääb S; Medizinische Klinik und Poliklinik I, LMU University Hospital Munich, Munich, Germany; German Center for Cardiovascular Research, Munich Heart Alliance, Munich, Germany.
Metzler B; Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
Joannidis M; Division of Intensive Care and Emergency Medicine, Department Internal Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Kain HU; Department of Internal Medicine, Hospital Mühldorf, Mühldorf, Germany.
Kaiser N; Department of Internal Medicine, Hospital St Johann in Tirol, St Johann in Tirol, Austria.
Schwinger R; Department of Internal Medicine, Hospital Weiden, Weiden, Germany.
Witzenbichler B; Department of Internal Medicine, Hospital Dachau, Dachau, Germany.
Alber H; Department of Internal Medicine and Cardiology, Klinikum Klagenfurt am Woerthersee, Klagenfurt, Austria.
Straube F; Department of Cardiology and Internal Intensive Care Medicine, Munich Clinic Bogenhausen and Schwabing, Munich, Germany.
Hartmann N; Department of Internal Medicine I (Cardiology), University Hospital Aachen, Aachen, Germany.
Achenbach S; Department of Cardiology and Angiology, University Hospital Erlangen, Erlangen, Germany.
von Bergwelt-Baildon M; Medizinische Klinik und Poliklinik III, LMU University Hospital Munich, Munich, Germany.
von Stülpnagel L; Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria; Medizinische Klinik und Poliklinik I, LMU University Hospital Munich, Munich, Germany; German Center for Cardiovascular Research, Munich Heart Alliance, Munich, Germany.
Schoenherr S; Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Forer L; Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
Embacher-Aichhorn S; Competence Center for Clinical Trials, Medical University of Innsbruck, Innsbruck, Austria.
Mansmann U; Institute for Medical Information Processing, Biometry, and Epidemiology, Ludwig-Maximilians-University Munich, Germany.
Rizas KD; Medizinische Klinik und Poliklinik I, LMU University Hospital Munich, Munich, Germany; German Center for Cardiovascular Research, Munich Heart Alliance, Munich, Germany.
Massberg S; Medizinische Klinik und Poliklinik I, LMU University Hospital Munich, Munich, Germany; German Center for Cardiovascular Research, Munich Heart Alliance, Munich, Germany. Electronic address: .
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Corporate Authors :
ACEI-COVID investigators
Źródło :
The Lancet. Respiratory medicine [Lancet Respir Med] 2021 Aug; Vol. 9 (8), pp. 863-872. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin Receptor Antagonists*/administration & dosage
Angiotensin Receptor Antagonists*/adverse effects
Angiotensin-Converting Enzyme Inhibitors*/administration & dosage
Angiotensin-Converting Enzyme Inhibitors*/adverse effects
COVID-19*/epidemiology
COVID-19*/metabolism
COVID-19*/therapy
Hypertension*/drug therapy
Hypertension*/epidemiology
Renin-Angiotensin System*/drug effects
Renin-Angiotensin System*/physiology
SARS-CoV-2*/drug effects
SARS-CoV-2*/physiology
Angiotensin-Converting Enzyme 2/metabolism ; Area Under Curve ; Female ; Humans ; Male ; Middle Aged ; Organ Dysfunction Scores ; Outcome and Process Assessment, Health Care ; Risk Adjustment/methods ; Severity of Illness Index ; Withholding Treatment/statistics & numerical data
Czasopismo naukowe
Tytuł :
ACE2-Targeting antibody suppresses SARS-CoV-2 Omicron and Delta variants.
Autorzy :
Ou J; Biotherapeutics Discovery Research Center, Shanghai Institute of Materia Medica, Shanghai, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.
Zhang Y; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.; University of Chinese Academy of Sciences, Beijing, China.
Wang Y; Biotherapeutics Discovery Research Center, Shanghai Institute of Materia Medica, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhang Z; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.; University of Chinese Academy of Sciences, Beijing, China.
Wei H; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.; University of Chinese Academy of Sciences, Beijing, China.
Yu J; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.; University of Chinese Academy of Sciences, Beijing, China.
Wang Q; Biotherapeutics Discovery Research Center, Shanghai Institute of Materia Medica, Shanghai, China.
Wang G; Biotherapeutics Discovery Research Center, Shanghai Institute of Materia Medica, Shanghai, China. .; University of Chinese Academy of Sciences, Beijing, China. .
Zhang B; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. .; University of Chinese Academy of Sciences, Beijing, China. .
Wang C; Biotherapeutics Discovery Research Center, Shanghai Institute of Materia Medica, Shanghai, China. .; University of Chinese Academy of Sciences, Beijing, China. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2022 Feb 09; Vol. 7 (1), pp. 43. Date of Electronic Publication: 2022 Feb 09.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2/*antagonists & inhibitors
Antibodies, Neutralizing/*pharmacology
Antibodies, Viral/*pharmacology
COVID-19/*drug therapy
Receptors, Virus/*antagonists & inhibitors
SARS-CoV-2/*drug effects
Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/immunology ; Animals ; COVID-19/immunology ; COVID-19/virology ; Enzyme-Linked Immunosorbent Assay ; Gene Expression ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Lung/drug effects ; Lung/immunology ; Lung/virology ; Mice ; Protein Binding/drug effects ; Receptors, Virus/genetics ; Receptors, Virus/immunology ; SARS-CoV-2/growth & development ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology
SCR Organism :
SARS-CoV-2 variants
Raport
Tytuł :
Dysregulation of ACE (Angiotensin-Converting Enzyme)-2 and Renin-Angiotensin Peptides in SARS-CoV-2 Mediated Mortality and End-Organ Injuries.
Autorzy :
Wang K; Division of Cardiology, Department of Medicine (K.W., A.N., G.Y.O.), University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute (K.W., M.G., A.N., G.Y.O.), University of Alberta, Edmonton, Canada.
Gheblawi M; Mazankowski Alberta Heart Institute (K.W., M.G., A.N., G.Y.O.), University of Alberta, Edmonton, Canada.; Department of Physiology (M.G., Z.K., G.Y.O.), University of Alberta, Edmonton, Canada.
Nikhanj A; Division of Cardiology, Department of Medicine (K.W., A.N., G.Y.O.), University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute (K.W., M.G., A.N., G.Y.O.), University of Alberta, Edmonton, Canada.
Munan M; Department of Critical Care Medicine (M.M., E.M., W.S.), University of Alberta, Edmonton, Canada.
MacIntyre E; Department of Critical Care Medicine (M.M., E.M., W.S.), University of Alberta, Edmonton, Canada.; Division of Respirology, Department of Medicine (E.M.), University of Alberta, Edmonton, Canada.
O'Neil C; Division of Cardiology, Department of Medicine (K.W., A.N., G.Y.O.), University of Alberta, Edmonton, Canada.; Division of Infectious Diseases, Department of Medicine (C.O., W.S.), University of Alberta, Edmonton, Canada.
Poglitsch M; Attoquant Diagnostics, Vienna, Austria (M.P.).
Colombo D; Pathology Unit, National Institute for Infectious Diseases 'Lazzaro Spallanzani,' IRCCS, Rome, Italy (D.C., F.D.N.).
Del Nonno F; Pathology Unit, National Institute for Infectious Diseases 'Lazzaro Spallanzani,' IRCCS, Rome, Italy (D.C., F.D.N.).
Kassiri Z; Department of Physiology (M.G., Z.K., G.Y.O.), University of Alberta, Edmonton, Canada.
Sligl W; Department of Critical Care Medicine (M.M., E.M., W.S.), University of Alberta, Edmonton, Canada.; Division of Infectious Diseases, Department of Medicine (C.O., W.S.), University of Alberta, Edmonton, Canada.
Oudit GY; Division of Cardiology, Department of Medicine (K.W., A.N., G.Y.O.), University of Alberta, Edmonton, Canada.; Mazankowski Alberta Heart Institute (K.W., M.G., A.N., G.Y.O.), University of Alberta, Edmonton, Canada.; Department of Physiology (M.G., Z.K., G.Y.O.), University of Alberta, Edmonton, Canada.
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Źródło :
Hypertension (Dallas, Tex. : 1979) [Hypertension] 2022 Feb; Vol. 79 (2), pp. 365-378. Date of Electronic Publication: 2021 Nov 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
SARS-CoV-2*
Angiotensin I/*blood
Angiotensin II/*blood
Angiotensin-Converting Enzyme 2/*blood
COVID-19/*blood
Peptide Fragments/*blood
Renin-Angiotensin System/*physiology
ADAM17 Protein/blood ; Aged ; COVID-19/mortality ; COVID-19/therapy ; Enzyme Activation ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Receptors, Tumor Necrosis Factor, Type I/blood ; Receptors, Tumor Necrosis Factor, Type II/blood ; Respiration, Artificial ; Risk ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Identification of deubiquitinase inhibitors via high-throughput screening using a fluorogenic ubiquitin-rhodamine assay.
Autorzy :
Varca AC; Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Casalena D; FAST Lab, Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
Auld D; FAST Lab, Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
Buhrlage SJ; Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
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Źródło :
STAR protocols [STAR Protoc] 2021 Oct 19; Vol. 2 (4), pp. 100896. Date of Electronic Publication: 2021 Oct 19 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Deubiquitinating Enzymes*/antagonists & inhibitors
Deubiquitinating Enzymes*/metabolism
Enzyme Inhibitors*
High-Throughput Screening Assays/*methods
Rhodamines/*metabolism
Ubiquitin/*metabolism
Enzyme Assays ; Escherichia coli/genetics ; Fluorescent Dyes/chemistry ; Recombinant Proteins/drug effects ; Recombinant Proteins/metabolism ; Small Molecule Libraries
Czasopismo naukowe
Tytuł :
In vitro study on the effect of leonurine hydrochloride on the enzyme activity of cytochrome P450 enzymes in human liver microsomes.
Autorzy :
Zhao H; Department of Nephrology, Yidu Central Hospital of Weifang, Weifang, Shandong, China.
Xue S; Department of Urology, Yidu Central Hospital of Weifang, Weifang, Shandong, China.
Meng Q; Department of Intravenous Drug Allocation, Weifang Maternal and Child Health Hospital, Weifang, China.
Zhou C; Department of Intravenous Drug Allocation, Weifang Maternal and Child Health Hospital, Weifang, China.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Sep; Vol. 51 (9), pp. 977-982. Date of Electronic Publication: 2021 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 Enzyme Inhibitors*/pharmacology
Microsomes, Liver*
Cytochrome P-450 Enzyme System ; Gallic Acid/analogs & derivatives ; Humans
Czasopismo naukowe
Tytuł :
Atypical kinetics of cytochrome P450 2J2: Epoxidation of arachidonic acid and reversible inhibition by xenobiotic inhibitors.
Autorzy :
Leow JWH; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543.
Verma RK; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671.
Lim ABH; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543.
Fan H; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671.
Chan ECY; Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore 117543. Electronic address: .
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2021 Sep 01; Vol. 164, pp. 105889. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 Enzyme Inhibitors*/pharmacology
Xenobiotics*
Arachidonic Acid ; Cytochrome P-450 Enzyme System/metabolism ; Kinetics
Czasopismo naukowe

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