Temat: "Enzyme Activation" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation.
Autorzy :: Sun J; Department of Structural Biology, St Jude Children's Research Hospital, Memphis, TN, USA. .; Pokaż więcej
Źródło :: Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Nov; Vol. 27 (11), pp. 1086-1093. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Enzyme Activation*
Dual Oxidases/*metabolism
Nerve Tissue Proteins/*metabolism
Nuclear Proteins/*metabolism
Animals ; Cryoelectron Microscopy ; Dual Oxidases/chemistry ; Dual Oxidases/ultrastructure ; Mice ; Models, Molecular ; NADP/metabolism ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/ultrastructure ; Nuclear Proteins/chemistry ; Nuclear Proteins/ultrastructure ; Protein Conformation
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation.
Autorzy :: Jia B; Department of Gastroenterology, Henan Provincial People's Hospital, Zhengzhou, 450003, China.; Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, W412 Research Building 3970 Reservoir Road NW, Washington, DC, 20057, USA.
Thompson HA; Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, W412 Research Building 3970 Reservoir Road NW, Washington, DC, 20057, USA.
Barndt RB; Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, W412 Research Building 3970 Reservoir Road NW, Washington, DC, 20057, USA.
Chiu YL; Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, W412 Research Building 3970 Reservoir Road NW, Washington, DC, 20057, USA.; Department of Biochemistry National Defense Medical Center, Taipei, 114, Taiwan.
Lee MJ; Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, W412 Research Building 3970 Reservoir Road NW, Washington, DC, 20057, USA.; Department of Bioscience Technology, Chang Jung Christian University, Tainan, 71101, Taiwan.; Department of Medical Science, Chang Jung Christian University, Tainan, 71101, Taiwan.
Lee SC; Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, W412 Research Building 3970 Reservoir Road NW, Washington, DC, 20057, USA.
Wang JK; Department of Biochemistry National Defense Medical Center, Taipei, 114, Taiwan.
Tang HJ; Section of Infectious Diseases, Internal Medicine, Chi-Mei Medical Center, No.901, Chung-Hwa Rd. Yung-Kang Dist., Tainan City, 71004, Taiwan, ROC. .
Lin CY; Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, W412 Research Building 3970 Reservoir Road NW, Washington, DC, 20057, USA. .
Johnson MD; Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, W412 Research Building 3970 Reservoir Road NW, Washington, DC, 20057, USA. .; Pokaż więcej
Źródło :: Human cell [Hum Cell] 2020 Oct; Vol. 33 (4), pp. 1068-1080. Date of Electronic Publication: 2020 Aug 10.
Typ publikacji :: Comparative Study; Journal Article
MeSH Terms :: Enzyme Activation*
Acids/*pharmacology
Enzyme Precursors/*metabolism
Serine Endopeptidases/*metabolism
Enzyme Precursors/chemistry ; Enzyme Precursors/genetics ; Humans ; Mutation ; Protein Domains/genetics ; Protein Processing, Post-Translational/genetics ; Proteinase Inhibitory Proteins, Secretory/pharmacology ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/genetics ; Tumor Cells, Cultured
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 3 3.

Tytuł :: Functional mechanism of AMPK activation in mitochondrial regeneration of rat peritoneal macrophages mediated by uremic serum.
Autorzy :: Chen; Department of Critical Care Medcine, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, China.
Zuo K; Department of Critical Care Medcine, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, China.
Liang X; Department of Critical Care Medcine, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, China.
Wang M; Department of Critical Care Medcine, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, China.
Zhang H; Department of Critical Care Medcine, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, China.
Zhou R; Department of Critical Care Medcine, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, China.
Liu X; Department of Critical Care Medcine, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, China.; Pokaż więcej
Źródło :: PloS one [PLoS One] 2020 Sep 28; Vol. 15 (9), pp. e0235960. Date of Electronic Publication: 2020 Sep 28 (Print Publication: 2020).
Typ publikacji :: Journal Article
MeSH Terms :: Enzyme Activation*
AMP-Activated Protein Kinases/*metabolism
Macrophages, Peritoneal/*metabolism
Mitochondria/*metabolism
Uremia/*metabolism
Animals ; Macrophages, Peritoneal/pathology ; Male ; Mitochondria/pathology ; Mitochondrial Dynamics ; RNA, Messenger/metabolism ; RNA, Mitochondrial/metabolism ; Rats ; Rats, Sprague-Dawley ; Uremia/blood ; Uremia/pathology
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 4 4.

Tytuł :: Sirtuin-1 expression and activity is diminished in aged liver grafts.
Autorzy :: Scheuermann U; Department of Visceral, Transplantation, Vascular, and Thoracic Surgery, University Hospital of Leipzig, Leipzig, Germany.
Seyferth ER; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Abraham N; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Kesseli SJ; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Halpern SE; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Zhu M; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Song M; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Hartwig MG; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Parker W; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Kwun J; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Cherry AD; Department of Anesthesiology, Duke University, Durham, USA.
Lee J; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Barbas AS; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA. .; Pokaż więcej
Źródło :: Scientific reports [Sci Rep] 2020 Jul 17; Vol. 10 (1), pp. 11860. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Enzyme Activation*
Gene Expression*
Liver Transplantation*
Organ Preservation*
Liver/*metabolism
Sirtuin 1/*genetics
Sirtuin 1/*metabolism
Animals ; Antioxidants/metabolism ; Biomarkers ; Cryopreservation ; Cytokines/metabolism ; Graft Survival ; Inflammation Mediators/metabolism ; Liver Function Tests ; Male ; Mitochondria/metabolism ; Models, Animal ; Oxygen Consumption ; Rats ; Reperfusion Injury ; Time Factors
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 5 5.

Tytuł :: Detailed analyses of the crucial functions of Zn transporter proteins in alkaline phosphatase activation.
Autorzy :: Suzuki E; Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
Ogawa N; Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
Takeda TA; Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
Nishito Y; Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
Tanaka YK; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Fujiwara T; Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan.
Matsunaga M; Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
Ueda S; Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
Kubo N; Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
Tsuji T; Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
Fukunaka A; Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8512, Japan.
Yamazaki T; Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan.
Taylor KM; School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, King Edward VIIth Avenue, Cardiff CF10 3NB, United Kingdom.
Ogra Y; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Kambe T; Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan. Electronic address: .; Pokaż więcej
Źródło :: The Journal of biological chemistry [J Biol Chem] 2020 Apr 24; Vol. 295 (17), pp. 5669-5684. Date of Electronic Publication: 2020 Mar 16.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Enzyme Activation*
Alkaline Phosphatase/*metabolism
Cation Transport Proteins/*metabolism
Zinc/*metabolism
Animals ; Avian Proteins/metabolism ; Cell Line ; Chickens ; Golgi Apparatus/metabolism ; Humans ; Protein Multimerization
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: Radio frequency energy inactivates peroxidase in stem lettuce at different heating rates and associate changes in physiochemical properties and cell morphology.
Autorzy :: Yao Y; College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
Sun Y; College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
Cui B; College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
Fu H; College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
Chen X; College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
Wang Y; College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China. Electronic address: .; Pokaż więcej
Źródło :: Food chemistry [Food Chem] 2021 Apr 16; Vol. 342, pp. 128360. Date of Electronic Publication: 2020 Oct 13.
Typ publikacji :: Journal Article
MeSH Terms :: Hot Temperature*
Radio Waves*
Chemical Phenomena/*radiation effects
Lettuce/*cytology
Lettuce/*radiation effects
Peroxidase/*metabolism
Color ; Enzyme Activation/radiation effects ; Food Handling ; Lettuce/enzymology ; Lettuce/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 7 7.

Tytuł :: Enterovirus 71 induces autophagy in mice via mTOR inhibition and ERK pathway activation.
Autorzy :: Wang B; School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Zhu Y; School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Liu L; School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Wang B; School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Chen M; School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Wang J; School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Yang L; School of Medicine, Dalian University, Dalian 116622, China. Electronic address: .
Liu J; School of Basic Medicine, Jiamusi University, Jiamusi 154007, China. Electronic address: .; Pokaż więcej
Źródło :: Life sciences [Life Sci] 2021 Apr 15; Vol. 271, pp. 119188. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :: Journal Article
MeSH Terms :: Autophagy/*physiology
Enterovirus A, Human/*metabolism
Enterovirus Infections/*metabolism
MAP Kinase Signaling System/*physiology
TOR Serine-Threonine Kinases/*antagonists & inhibitors
TOR Serine-Threonine Kinases/*metabolism
Animals ; Animals, Newborn ; Cell Line, Tumor ; Enterovirus Infections/pathology ; Enzyme Activation/physiology ; Female ; Humans ; Male ; Mice ; Mice, Inbred BALB C
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 8 8.

Tytuł :: Blockade of alcohol excessive and "relapse" drinking in male mice by pharmacological cryptochrome (CRY) activation.
Autorzy :: Zhou Y; Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, 10065, USA. .
Kreek MJ; Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, 10065, USA.; Pokaż więcej
Źródło :: Psychopharmacology [Psychopharmacology (Berl)] 2021 Apr; Vol. 238 (4), pp. 1099-1109. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :: Journal Article
MeSH Terms :: Alcoholism/*prevention & control
Central Nervous System Depressants/*blood
Cryptochromes/*drug effects
Ethanol/*blood
Alcohol Drinking/psychology ; Animals ; Carbazoles/pharmacology ; Dose-Response Relationship, Drug ; Drug Tolerance ; Enzyme Activation/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Recurrence ; Substance Withdrawal Syndrome/drug therapy ; Substance Withdrawal Syndrome/psychology ; Sulfonamides/pharmacology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: CARD8 is an inflammasome sensor for HIV-1 protease activity.
Autorzy :: Wang Q; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Gao H; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Clark KM; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Mugisha CS; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO, USA.
Davis K; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO, USA.
Tang JP; Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO, USA.
Harlan GH; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
DeSelm CJ; Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO, USA.; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO, USA.
Presti RM; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Kutluay SB; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO, USA.
Shan L; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA. .; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO, USA.; Pokaż więcej
Źródło :: Science (New York, N.Y.) [Science] 2021 Mar 19; Vol. 371 (6535). Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :: Pyroptosis*
CARD Signaling Adaptor Proteins/*metabolism
HIV Infections/*virology
HIV Protease/*metabolism
HIV-1/*physiology
Inflammasomes/*metabolism
Neoplasm Proteins/*metabolism
Alkynes/pharmacology ; Anti-HIV Agents/pharmacology ; Benzoxazines/pharmacology ; CARD Signaling Adaptor Proteins/chemistry ; CD4-Positive T-Lymphocytes/physiology ; CD4-Positive T-Lymphocytes/virology ; Caspase 1/metabolism ; Cyclopropanes/pharmacology ; Enzyme Activation ; HIV Infections/drug therapy ; HIV-1/drug effects ; Humans ; Macrophages/physiology ; Macrophages/virology ; Neoplasm Proteins/chemistry ; Reverse Transcriptase Inhibitors/pharmacology ; Rilpivirine/pharmacology ; THP-1 Cells ; Virus Latency
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 10 10.

Tytuł :: Phosphorylation and chromatin tethering prevent cGAS activation during mitosis.
Autorzy :: Li T; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.; Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
Huang T; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.; Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
Du M; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.; Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
Chen X; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.; Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
Du F; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.; Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
Ren J; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.; Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.
Chen ZJ; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA. .; Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.; Pokaż więcej
Źródło :: Science (New York, N.Y.) [Science] 2021 Mar 19; Vol. 371 (6535). Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Mitosis*
Chromatin/*metabolism
Nucleotidyltransferases/*metabolism
Aurora Kinase B/metabolism ; Cell Cycle ; Cell Line ; DNA/metabolism ; DNA, Mitochondrial/metabolism ; Enzyme Activation ; Humans ; Nucleotides, Cyclic/metabolism ; Nucleotidyltransferases/chemistry ; Phosphorylation ; Protein Multimerization
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 11 11.

Tytuł :: The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence.
Autorzy :: Zhu W; Biomedical Sciences Research Complex, School of Biology, University of St Andrews, St Andrews KY16 9ST, UK.
McQuarrie S; Biomedical Sciences Research Complex, School of Biology, University of St Andrews, St Andrews KY16 9ST, UK.
Grüschow S; Biomedical Sciences Research Complex, School of Biology, University of St Andrews, St Andrews KY16 9ST, UK.
McMahon SA; Biomedical Sciences Research Complex, School of Biology, University of St Andrews, St Andrews KY16 9ST, UK.
Graham S; Biomedical Sciences Research Complex, School of Biology, University of St Andrews, St Andrews KY16 9ST, UK.
Gloster TM; Biomedical Sciences Research Complex, School of Biology, University of St Andrews, St Andrews KY16 9ST, UK.
White MF; Biomedical Sciences Research Complex, School of Biology, University of St Andrews, St Andrews KY16 9ST, UK.; Pokaż więcej
Źródło :: Nucleic acids research [Nucleic Acids Res] 2021 Mar 18; Vol. 49 (5), pp. 2777-2789.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: CRISPR-Cas Systems*
CRISPR-Associated Proteins/*chemistry
Deoxyribonuclease I/*chemistry
Ribonucleases/*chemistry
Clostridiales/enzymology ; Clustered Regularly Interspaced Short Palindromic Repeats ; DNA/chemistry ; Deoxyribonuclease I/metabolism ; Enzyme Activation ; Escherichia coli/virology ; Interspersed Repetitive Sequences ; Metals/chemistry ; Models, Molecular ; Protein Domains ; Ribonucleases/metabolism
SCR Organism :: Sulfobacillus thermosulfidooxidans
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 12 12.

Tytuł :: Anticancer activity of new cationic arylthiophenes against hepatocellular carcinoma.
Autorzy :: Al-Shun SA; Division of Biochemistry, Department of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, Egypt. Electronic address: .
El-Senduny FF; Division of Biochemistry, Department of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, Egypt. Electronic address: .
Ismail MA; Division of Organic Chemistry, Department of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, Egypt. Electronic address: .
El-Sayed WM; Department of Zoology, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt. Electronic address: .
Badria FA; Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. Electronic address: .
Youssef MM; Division of Biochemistry, Department of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, Egypt. Electronic address: .; Pokaż więcej
Źródło :: Life sciences [Life Sci] 2021 Mar 15; Vol. 269, pp. 119028. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :: Journal Article
MeSH Terms :: Antineoplastic Agents/*therapeutic use
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
Thiophenes/*therapeutic use
Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Carcinoma, Hepatocellular/pathology ; Caspases/metabolism ; Cations ; Cell Cycle Checkpoints/drug effects ; Cell Death/drug effects ; Cell Movement/drug effects ; Cell Survival/drug effects ; Cisplatin/pharmacology ; Doxorubicin/pharmacology ; Enzyme Activation/drug effects ; G2 Phase/drug effects ; Hep G2 Cells ; Humans ; Liver Neoplasms/pathology ; Mitosis/drug effects ; Paclitaxel/pharmacology ; Structure-Activity Relationship ; Thiophenes/chemistry ; Thiophenes/pharmacology ; Tumor Stem Cell Assay ; Wound Healing/drug effects
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 13 13.

Tytuł :: The intricate biophysical puzzle of caspase-1 activation.
Autorzy :: Makoni NJ; Department of Chemistry & Biochemistry, University of Missouri-St. Louis, St. Louis, MO, USA.
Nichols MR; Department of Chemistry & Biochemistry, University of Missouri-St. Louis, St. Louis, MO, USA. Electronic address: .; Pokaż więcej
Źródło :: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Mar 15; Vol. 699, pp. 108753. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :: Caspase 1/*metabolism
Animals ; Caspase 1/chemistry ; Cell Line, Tumor ; Enzyme Activation/physiology ; Humans ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Protein Multimerization/physiology ; Proteolysis
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 14 14.

Tytuł :: Inactivation of polyphenol oxidase by microwave and conventional heating: Investigation of thermal and non-thermal effects of focused microwaves.
Autorzy :: Bulhões Bezerra Cavalcante TA; Department of Chemical Engineering, Escola Politécnica, University of São Paulo, Brazil.
Santos Funcia ED; Department of Chemical Engineering, Escola Politécnica, University of São Paulo, Brazil.
Wilhelms Gut JA; Department of Chemical Engineering, Escola Politécnica, University of São Paulo, Brazil; FoRC - Food Center Research, University of São Paulo, Brazil. Electronic address: .; Pokaż więcej
Źródło :: Food chemistry [Food Chem] 2021 Mar 15; Vol. 340, pp. 127911. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :: Journal Article
MeSH Terms :: Catechol Oxidase/*chemistry
Pasteurization/*methods
Agaricales/enzymology ; Buffers ; Catechol Oxidase/metabolism ; Cocos/enzymology ; Enzyme Activation ; Food-Processing Industry/methods ; Heating ; Kinetics ; Microwaves ; Models, Theoretical ; Monophenol Monooxygenase/chemistry ; Monophenol Monooxygenase/metabolism ; Temperature
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 15 15.

Tytuł :: Sotolon is a natural virulence mitigating agent in Serratia marcescens.
Autorzy :: Abbas HA; Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt. .
Goda RM; Department of Microbiology and Biotechnology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Mansoura, Egypt.; Pokaż więcej
Źródło :: Archives of microbiology [Arch Microbiol] 2021 Mar; Vol. 203 (2), pp. 533-541. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :: Journal Article
MeSH Terms :: Furans/*pharmacology
Gene Expression Regulation, Bacterial/*drug effects
Serratia marcescens/*drug effects
Serratia marcescens/*pathogenicity
Virulence Factors/*genetics
Anti-Bacterial Agents/pharmacology ; Biofilms/drug effects ; Cross Infection/drug therapy ; Enzyme Activation/drug effects ; Humans ; Peptide Hydrolases/metabolism ; Prodigiosin/metabolism ; Quorum Sensing/drug effects ; Serratia Infections/drug therapy ; Serratia marcescens/genetics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 16 16.

Tytuł :: Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
Autorzy :: Nguyen NT; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Du K; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Akakpo JY; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Umbaugh DS; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Jaeschke H; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Ramachandran A; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, 66160, USA. Electronic address: .; Pokaż więcej
Źródło :: Toxicology letters [Toxicol Lett] 2021 Mar 01; Vol. 338, pp. 21-31. Date of Electronic Publication: 2020 Dec 05.
Typ publikacji :: Journal Article
MeSH Terms :: Acetaminophen*
Drug Overdose*
Chemical and Drug Induced Liver Injury/*enzymology
Cytosol/*enzymology
Hepatocytes/*enzymology
JNK Mitogen-Activated Protein Kinases/*metabolism
Mitochondria, Liver/*enzymology
Mitochondrial Proteins/*metabolism
Superoxides/*metabolism
Animals ; Benzoquinones/metabolism ; Cells, Cultured ; Chemical and Drug Induced Liver Injury/pathology ; Disease Models, Animal ; Enzyme Activation ; Hepatocytes/pathology ; Imines/metabolism ; Male ; Mice, Inbred C57BL ; Mitochondria, Liver/pathology ; Oxidative Stress ; Protein Transport ; Time Factors
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 17 17.

Tytuł :: p67 -derived self-assembled peptides prevent Nox2 NADPH oxidase activation by an auto-inhibitory mechanism.
Autorzy :: Bechor E; The Julius Friedrich Cohnheim Laboratory of Phagocyte Research, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Zahavi A; The Julius Friedrich Cohnheim Laboratory of Phagocyte Research, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Berdichevsky Y; The Julius Friedrich Cohnheim Laboratory of Phagocyte Research, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Pick E; The Julius Friedrich Cohnheim Laboratory of Phagocyte Research, Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pokaż więcej
Źródło :: Journal of leukocyte biology [J Leukoc Biol] 2021 Mar; Vol. 109 (3), pp. 657-673. Date of Electronic Publication: 2020 Jul 08.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: NADPH Oxidase 2/*antagonists & inhibitors
NADPH Oxidase 2/*metabolism
Peptides/*pharmacology
Phosphoproteins/*metabolism
Amino Acid Sequence ; Animals ; Enzyme Activation/drug effects ; Guinea Pigs ; Hydrophobic and Hydrophilic Interactions ; Peptides/chemistry ; Protein Domains
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 18 18.

Tytuł :: Activation of the extracellular signal-regulated kinase pathway is required for replication of Newcastle disease virus.
Autorzy :: Ni J; Key Laboratory of Animal Infectious Diseases, School of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, China.
Hu S; Key Laboratory of Animal Infectious Diseases, School of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, China.; Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agri-Food Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, 225009, China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, No. 12, East Wenhui Rd, Yangzhou, 225009, Jiangsu, China.
Wang X; Key Laboratory of Animal Infectious Diseases, School of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, China.; Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agri-Food Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, 225009, China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, No. 12, East Wenhui Rd, Yangzhou, 225009, Jiangsu, China.
Liu X; Key Laboratory of Animal Infectious Diseases, School of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, China.; Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agri-Food Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, 225009, China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, No. 12, East Wenhui Rd, Yangzhou, 225009, Jiangsu, China.
Hu Z; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, China. .; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, No. 12, East Wenhui Rd, Yangzhou, 225009, Jiangsu, China. .
Liu X; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, China. .; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, No. 12, East Wenhui Rd, Yangzhou, 225009, Jiangsu, China. .; Pokaż więcej
Źródło :: Archives of virology [Arch Virol] 2021 Mar; Vol. 166 (3), pp. 921-927. Date of Electronic Publication: 2021 Jan 24.
Typ publikacji :: Journal Article
MeSH Terms :: Extracellular Signal-Regulated MAP Kinases/*metabolism
MAP Kinase Signaling System/*physiology
Newcastle Disease/*pathology
Newcastle disease virus/*genetics
Virus Replication/*physiology
Animals ; Cell Line ; Chick Embryo ; Chickens/virology ; Cytopathogenic Effect, Viral/genetics ; Enzyme Activation ; Newcastle Disease/virology ; Newcastle disease virus/growth & development
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 19 19.

Tytuł :: CircRNA-100284 activates aurora kinase B by inducing methylation of HSP70 via microRNA-217 to promote proliferation of bladder cancer cells.
Autorzy :: Huang ZM; Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing, Dongcheng, Beijing, 100730, China.
Wang H; Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing, Dongcheng, Beijing, 100730, China.
Ji ZG; Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing, Dongcheng, Beijing, 100730, China. .; Pokaż więcej
Źródło :: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Mar; Vol. 147 (3), pp. 703-712. Date of Electronic Publication: 2021 Jan 01.
Typ publikacji :: Journal Article
MeSH Terms :: Aurora Kinase B/*metabolism
HSP70 Heat-Shock Proteins/*metabolism
MicroRNAs/*metabolism
RNA, Circular/*metabolism
Urinary Bladder Neoplasms/*metabolism
Animals ; Arsenites/pharmacology ; Aurora Kinase B/genetics ; Cell Cycle/physiology ; Cell Line, Tumor ; Cell Proliferation/physiology ; Cell Transformation, Neoplastic/chemically induced ; Cyclin D2/genetics ; Cyclin D2/metabolism ; Enhancer of Zeste Homolog 2 Protein/genetics ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Enzyme Activation ; Female ; HSP70 Heat-Shock Proteins/genetics ; Heterografts ; Humans ; Methylation ; Mice ; MicroRNAs/genetics ; RNA, Circular/genetics ; Up-Regulation ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/pathology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 20 20.

Tytuł :: Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.
Autorzy :: Ogden TEH; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Yang JC; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Schimpl M; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
Easton LE; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Underwood E; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
Rawlins PB; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
McCauley MM; Department of Biochemistry & Molecular Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Langelier MF; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada.
Pascal JM; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada.
Embrey KJ; Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
Neuhaus D; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.; Pokaż więcej
Źródło :: Nucleic acids research [Nucleic Acids Res] 2021 Feb 26; Vol. 49 (4), pp. 2266-2288.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Poly (ADP-Ribose) Polymerase-1/*chemistry
Allosteric Regulation ; Amides/chemistry ; Catalytic Domain ; Crystallography, X-Ray ; DNA Damage ; Enzyme Activation ; Models, Molecular ; Mutation ; Poly (ADP-Ribose) Polymerase-1/antagonists & inhibitors ; Poly (ADP-Ribose) Polymerase-1/genetics ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors/chemistry ; Protein Domains
: Czasopismo naukowe

Szczegóły

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