Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Ukraiński (UK)
Przejdź do strony domowej biblioteki Uniwersytet Ekonomiczny we Wrocławiu Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaUniwersytet Ekonomiczny we Wrocławiu

Wyszukujesz frazę ""Enzyme Activation"" wg kryterium: Temat

  Lista filtrów
Wyrównaj
Wyświetlanie 1-20 z 66122
Tytuł:
Activation Loop Plasticity and Active Site Coupling in the MAP Kinase, ERK2.
Autorzy:
Pegram L; Department of Biochemistry, University of Colorado, Boulder, CO 80305, USA.
Riccardi D; Thermodynamics Research Center, Applied Chemicals and Materials Division, National Institute of Standards and Technology, Boulder, CO, USA.
Ahn N; Department of Biochemistry, University of Colorado, Boulder, CO 80305, USA. Electronic address: .
Pokaż więcej
Źródło:
Journal of molecular biology [J Mol Biol] 2023 Dec 01; Vol. 435 (23), pp. 168309. Date of Electronic Publication: 2023 Oct 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Catalytic Domain*
Mitogen-Activated Protein Kinase 1*/chemistry
AAA Domain*
Molecular Dynamics Simulation ; Phosphorylation ; Enzyme Activation ; Crystallography, X-Ray
Czasopismo naukowe
Szczegóły
Tytuł:
Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor.
Autorzy:
Burghi V; Moores Cancer Center, University of California San Diego, La Jolla, California, USA; Department of Pharmacology, University of California San Diego, La Jolla, California, USA.
Paradis JS; Moores Cancer Center, University of California San Diego, La Jolla, California, USA; Department of Pharmacology, University of California San Diego, La Jolla, California, USA.
Officer A; Moores Cancer Center, University of California San Diego, La Jolla, California, USA; Department of Pharmacology, University of California San Diego, La Jolla, California, USA.
Adame-Garcia SR; Moores Cancer Center, University of California San Diego, La Jolla, California, USA; Department of Pharmacology, University of California San Diego, La Jolla, California, USA.
Wu X; Moores Cancer Center, University of California San Diego, La Jolla, California, USA; Department of Pharmacology, University of California San Diego, La Jolla, California, USA.
Matthees ESF; Institut für Molekulare Zellbiologie, CMB - Center for Molecular Biomedicine, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Jena, Germany.
Barsi-Rhyne B; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA.
Ramms DJ; Moores Cancer Center, University of California San Diego, La Jolla, California, USA; Department of Pharmacology, University of California San Diego, La Jolla, California, USA.
Clubb L; Moores Cancer Center, University of California San Diego, La Jolla, California, USA; Department of Pharmacology, University of California San Diego, La Jolla, California, USA.
Acosta M; Moores Cancer Center, University of California San Diego, La Jolla, California, USA; Department of Pharmacology, University of California San Diego, La Jolla, California, USA.
Tamayo P; Moores Cancer Center, University of California San Diego, La Jolla, California, USA.
Bouvier M; Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer, Université de Montréal, Québec, Canada.
Inoue A; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan.
von Zastrow M; Department of Psychiatry and Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, USA.
Hoffmann C; Institut für Molekulare Zellbiologie, CMB - Center for Molecular Biomedicine, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Jena, Germany.
Gutkind JS; Moores Cancer Center, University of California San Diego, La Jolla, California, USA; Department of Pharmacology, University of California San Diego, La Jolla, California, USA. Electronic address: .
Pokaż więcej
Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Nov; Vol. 299 (11), pp. 105293. Date of Electronic Publication: 2023 Sep 27.
Typ publikacji:
Journal Article
MeSH Terms:
beta-Arrestins*/genetics
beta-Arrestins*/metabolism
Gene Expression Regulation*/genetics
GTP-Binding Proteins*/metabolism
Receptors, Adrenergic, beta-2*/chemistry
Receptors, Adrenergic, beta-2*/genetics
Receptors, Adrenergic, beta-2*/metabolism
Humans ; beta-Arrestin 1/genetics ; beta-Arrestin 1/metabolism ; beta-Arrestin 2/genetics ; beta-Arrestin 2/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Mitogen-Activated Protein Kinases/metabolism ; Phosphorylation ; HEK293 Cells ; GTP-Binding Protein alpha Subunits/genetics ; GTP-Binding Protein alpha Subunits/metabolism ; Protein Structure, Tertiary ; Protein Isoforms ; Enzyme Activation/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
Time-resolved study on signaling pathway of photoactivated adenylate cyclase and its nonlinear optical response.
Autorzy:
Nakasone Y; Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto, Japan.
Murakami H; Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto, Japan.
Tokonami S; Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto, Japan.
Oda T; Department of Life Science and Research Center for Life Science, College of Science, Rikkyo University, Tokyo, Japan.
Terazima M; Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto, Japan. Electronic address: .
Pokaż więcej
Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Nov; Vol. 299 (11), pp. 105285. Date of Electronic Publication: 2023 Sep 22.
Typ publikacji:
Journal Article
MeSH Terms:
Adenylyl Cyclases*/genetics
Adenylyl Cyclases*/metabolism
Adenylyl Cyclases*/radiation effects
Bacterial Proteins*/genetics
Bacterial Proteins*/metabolism
Bacterial Proteins*/radiation effects
Light*
Signal Transduction*
Protein Subunits ; Enzyme Activation/radiation effects ; Mutation
SCR Organism:
Oscillatoria acuminata
Czasopismo naukowe
Szczegóły
Tytuł:
Co-folding and RNA activation of poliovirus 3C polyprotein precursors.
Autorzy:
Campagnola G; Department of Biochemistry & Molecular Birology, Colorado State University, Fort Collins, Colorado, USA.
Peersen O; Department of Biochemistry & Molecular Birology, Colorado State University, Fort Collins, Colorado, USA. Electronic address: .
Pokaż więcej
Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Nov; Vol. 299 (11), pp. 105258. Date of Electronic Publication: 2023 Sep 15.
Typ publikacji:
Journal Article
MeSH Terms:
Peptide Hydrolases*/chemistry
Peptide Hydrolases*/metabolism
Poliovirus*/chemistry
Poliovirus*/genetics
Viral Proteins*/chemistry
Viral Proteins*/genetics
Viral Proteins*/metabolism
Protein Folding*
Polyproteins/genetics ; Polyproteins/metabolism ; RNA, Viral/genetics ; RNA, Viral/isolation & purification ; RNA, Viral/metabolism ; Circular Dichroism ; Protein Stability ; Enzyme Activation ; Protein Structure, Secondary ; Amino Acid Sequence
Czasopismo naukowe
Szczegóły
Tytuł:
The effect of linker conformation on performance and stability of a two-domain lytic polysaccharide monooxygenase.
Autorzy:
Forsberg Z; Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences (NMBU), Ås, Norway. Electronic address: .
Stepnov AA; Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences (NMBU), Ås, Norway.
Tesei G; Structural Biology and NMR Laboratory, Department of Biology, Linderstrøm-Lang Centre for Protein Science, University of Copenhagen, Copenhagen, Denmark.
Wang Y; Structural Biology and NMR Laboratory, Department of Biology, Linderstrøm-Lang Centre for Protein Science, University of Copenhagen, Copenhagen, Denmark; College of Life Sciences, Zhejiang University, Hangzhou, China.
Buchinger E; Vectron Biosolutions AS, Trondheim, Norway; Department of Biotechnology and Food Science, NTNU Norwegian University of Science and Technology, Trondheim, Norway.
Kristiansen SK; Department of Biotechnology and Food Science, NTNU Norwegian University of Science and Technology, Trondheim, Norway.
Aachmann FL; Department of Biotechnology and Food Science, NTNU Norwegian University of Science and Technology, Trondheim, Norway.
Arleth L; X-ray and Neutron Science, Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark.
Eijsink VGH; Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences (NMBU), Ås, Norway.
Lindorff-Larsen K; Structural Biology and NMR Laboratory, Department of Biology, Linderstrøm-Lang Centre for Protein Science, University of Copenhagen, Copenhagen, Denmark.
Courtade G; Department of Biotechnology and Food Science, NTNU Norwegian University of Science and Technology, Trondheim, Norway. Electronic address: .
Pokaż więcej
Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Nov; Vol. 299 (11), pp. 105262. Date of Electronic Publication: 2023 Sep 19.
Typ publikacji:
Journal Article
MeSH Terms:
Mixed Function Oxygenases*/chemistry
Mixed Function Oxygenases*/metabolism
Fungal Proteins*/chemistry
Fungal Proteins*/metabolism
Models, Molecular*
Protein Folding*
Catalytic Domain ; Cellulose/metabolism ; Polysaccharides/metabolism ; Serine ; Protein Stability ; Enzyme Activation ; Molecular Docking Simulation ; Streptomyces/enzymology ; Protein Structure, Tertiary
Czasopismo naukowe
Szczegóły
Tytuł:
Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity.
Autorzy:
Lelyveld VS; Center for Computational and Integrative Biology, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Fang Z; Center for Computational and Integrative Biology, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.
Szostak JW; Center for Computational and Integrative Biology, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.; Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Pokaż więcej
Źródło:
Science (New York, N.Y.) [Science] 2023 Oct 27; Vol. 382 (6669), pp. 423-429. Date of Electronic Publication: 2023 Oct 26.
Typ publikacji:
Journal Article
MeSH Terms:
Calcium*/chemistry
DNA*/biosynthesis
DNA-Directed DNA Polymerase*/chemistry
Coenzymes*/chemistry
Geobacillus stearothermophilus*/enzymology
Bacterial Proteins*/chemistry
Nucleotides/chemistry ; Enzyme Activation ; Crystallography, X-Ray ; Protein Conformation ; Biocatalysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibition of fatty acid oxidation enables heart regeneration in adult mice.
Autorzy:
Li X; Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Wu F; Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Günther S; Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Looso M; Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Kuenne C; Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Zhang T; Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Wiesnet M; Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Klatt S; Institute for Vascular Signaling, Centre for Molecular Medicine, Goethe-University, Frankfurt am Main, Germany.
Zukunft S; Institute for Vascular Signaling, Centre for Molecular Medicine, Goethe-University, Frankfurt am Main, Germany.
Fleming I; Institute for Vascular Signaling, Centre for Molecular Medicine, Goethe-University, Frankfurt am Main, Germany.
Poschet G; Metabolomics Core Technology Platform, Centre for Organismal Studies (COS), Heidelberg University, Heidelberg, Germany.
Wietelmann A; Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Atzberger A; Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Potente M; Angiogenesis and Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Max Delbrück Center for Molecular Medicine, Helmholtz Association of German Research Centres, Berlin, Germany.; Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Yuan X; Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany. .; Instituto de Investigacion en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society, Buenos Aires, Argentina. .
Braun T; Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany. .; Instituto de Investigacion en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society, Buenos Aires, Argentina. .
Pokaż więcej
Źródło:
Nature [Nature] 2023 Oct; Vol. 622 (7983), pp. 619-626. Date of Electronic Publication: 2023 Sep 27.
Typ publikacji:
Journal Article
MeSH Terms:
Cellular Reprogramming*
Fatty Acids*/metabolism
Heart*/physiology
Regeneration*/physiology
Animals ; Mice ; Carnitine O-Palmitoyltransferase/deficiency ; Carnitine O-Palmitoyltransferase/genetics ; Cell Hypoxia ; Cell Proliferation ; Energy Metabolism ; Enzyme Activation ; Epigenesis, Genetic ; Histone Demethylases/metabolism ; Ketoglutaric Acids/metabolism ; Mutation ; Myocardium ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/metabolism ; Oxidation-Reduction ; Reperfusion Injury ; Transcription, Genetic
Czasopismo naukowe
Szczegóły
Tytuł:
The intersection between cysteine proteases, Ca signalling and cancer cell apoptosis.
Autorzy:
Hua T; School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia. Electronic address: .
Robitaille M; School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia. Electronic address: .
Roberts-Thomson SJ; School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia. Electronic address: .
Monteith GR; School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia; Mater Research Institute, Translational Research Institute, The University of Queensland, Brisbane, QLD, Australia. Electronic address: .
Pokaż więcej
Źródło:
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2023 Oct; Vol. 1870 (7), pp. 119532. Date of Electronic Publication: 2023 Jun 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms:
Apoptosis*
Neoplasms*/metabolism
Neoplasms*/pathology
Calcium Signaling*
Humans ; Animals ; Enzyme Activation ; Cysteine Proteases/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation.
Autorzy:
Juyoux P; European Molecular Biology Laboratory (EMBL), Grenoble, France.
Galdadas I; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Gobbo D; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
von Velsen J; European Molecular Biology Laboratory (EMBL), Grenoble, France.
Pelosse M; European Molecular Biology Laboratory (EMBL), Grenoble, France.
Tully M; European Synchrotron Radiation Facility, Grenoble, France.
Vadas O; Protein and peptide purification platform, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Gervasio FL; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.; Department of Chemistry, University College London, London, UK.; Institute of Structural and Molecular Biology, University College London, London, UK.; Swiss Institute of Bioinformatics, Geneva, Switzerland.
Pellegrini E; European Molecular Biology Laboratory (EMBL), Grenoble, France.
Bowler MW; European Molecular Biology Laboratory (EMBL), Grenoble, France.
Pokaż więcej
Źródło:
Science (New York, N.Y.) [Science] 2023 Sep 15; Vol. 381 (6663), pp. 1217-1225. Date of Electronic Publication: 2023 Sep 14.
Typ publikacji:
Journal Article
MeSH Terms:
MAP Kinase Kinase 2*/chemistry
MAP Kinase Kinase 6*/chemistry
Mitogen-Activated Protein Kinase 14*/chemistry
Cryoelectron Microscopy ; Enzyme Activation ; Phosphorylation ; Substrate Specificity ; Protein Conformation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Colorectal cancer-associated mutations impair EphB1 kinase function.
Autorzy:
Kim Y; Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York, USA.
Ahmed S; Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York, USA.
Miller WT; Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York, USA; Department of Veterans Affairs Medical Center, Northport, New York, USA. Electronic address: .
Pokaż więcej
Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Sep; Vol. 299 (9), pp. 105115. Date of Electronic Publication: 2023 Jul 30.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/physiopathology
Receptor, EphB1*/genetics
Receptor, EphB1*/metabolism
Animals ; Humans ; Mutation ; Signal Transduction/physiology ; Cell Line ; Enzyme Activation/genetics ; Protein Stability ; MAP Kinase Signaling System/genetics ; Cell Movement/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
A conserved arginine within the αC-helix of Erk1/2 is a latch of autoactivation and of oncogenic capabilities.
Autorzy:
Soudah N; Department of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel.
Baskin A; Department of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel.
Smorodinsky-Atias K; School of Neurobiology, Biochemistry and Biophysics, Tel Aviv University, Tel Aviv-Yafo, Israel.
Beenstock J; Department of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel.
Ganon Y; Department of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel.
Hayouka R; The Robert H. Smith Institute of Plant Sciences and Genetics in Agriculture, The Hebrew University of Jerusalem, Rehovot, Israel.
Aboraya M; The Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
Livnah O; Department of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel; The Wolfson Centre for Applied Structural Biology, Jerusalem, Israel.
Ilouz R; The Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
Engelberg D; Department of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem, Israel; Singapore-HUJ Alliance for Research and Enterprise, Mechanisms of Liver Inflammatory Diseases Program, National University of Singapore, Singapore; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: .
Pokaż więcej
Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Sep; Vol. 299 (9), pp. 105072. Date of Electronic Publication: 2023 Jul 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arginine*/metabolism
Mitogen-Activated Protein Kinase 1*/chemistry
Mitogen-Activated Protein Kinase 1*/genetics
Mitogen-Activated Protein Kinase 1*/metabolism
Mitogen-Activated Protein Kinase 3*/chemistry
Mitogen-Activated Protein Kinase 3*/genetics
Mitogen-Activated Protein Kinase 3*/metabolism
Phosphorylation ; Humans ; Animals ; Mice ; Cell Line ; HEK293 Cells ; Enzyme Activation/genetics ; Mutation ; Saccharomyces cerevisiae/enzymology ; Saccharomyces cerevisiae/genetics ; Protein Structure, Tertiary ; Models, Molecular ; Crystallization ; Amino Acid Sequence
Czasopismo naukowe
Szczegóły
Tytuł:
Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain.
Autorzy:
Clark NE; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, USA. Electronic address: .
Katolik A; Department of Chemistry, McGill University, Montreal, Quebec, Canada.
Gallant P; Department of Chemistry, McGill University, Montreal, Quebec, Canada.
Welch A; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, USA.
Murphy E; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, USA.
Buerer L; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, USA.
Schorl C; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, USA.
Naik N; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, USA.
Naik MT; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, USA.
Holloway SP; Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, USA.
Cano K; Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, USA.
Weintraub ST; Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, USA.
Howard KM; Department of Biomedical Sciences, School of Dental Medicine, University of Nevada-Las Vegas, Las Vegas, Nevada, USA.
Hart PJ; Department of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, USA.
Jogl G; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, USA.
Damha MJ; Department of Chemistry, McGill University, Montreal, Quebec, Canada. Electronic address: masad_.
Fairbrother WG; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island, USA. Electronic address: william_.
Pokaż więcej
Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Sep; Vol. 299 (9), pp. 105100. Date of Electronic Publication: 2023 Jul 26.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
RNA Nucleotidyltransferases*/genetics
RNA Nucleotidyltransferases*/metabolism
Adaptor Proteins, Signal Transducing*/metabolism
Humans ; Introns ; RNA Splicing ; Enzyme Activation/genetics ; Protein Domains ; Protein Binding ; Intrinsically Disordered Proteins/genetics ; Intrinsically Disordered Proteins/metabolism ; Entamoeba histolytica/enzymology ; Entamoeba histolytica/genetics ; Metals, Heavy/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Oligomerization-mediated activation of a short prokaryotic Argonaute.
Autorzy:
Shen Z; Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, USA.; Comprehensive Cancer Center and Center for Cancer Metabolism, The Ohio State University, Columbus, OH, USA.
Yang XY; Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, USA.; Comprehensive Cancer Center and Center for Cancer Metabolism, The Ohio State University, Columbus, OH, USA.; The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH, USA.
Xia S; Divison of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Huang W; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Taylor DJ; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Nakanishi K; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.
Fu TM; Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, USA. .; Comprehensive Cancer Center and Center for Cancer Metabolism, The Ohio State University, Columbus, OH, USA. .; The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH, USA. .
Pokaż więcej
Źródło:
Nature [Nature] 2023 Sep; Vol. 621 (7977), pp. 154-161. Date of Electronic Publication: 2023 Jul 26.
Typ publikacji:
Journal Article
MeSH Terms:
Argonaute Proteins*/chemistry
Argonaute Proteins*/classification
Argonaute Proteins*/metabolism
Prokaryotic Cells*/metabolism
Apoproteins/chemistry ; Apoproteins/metabolism ; DNA/metabolism ; Enzyme Activation ; NAD/metabolism ; RNA/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Diversity of function and higher-order structure within HWE sensor histidine kinases.
Autorzy:
Dikiy I; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, New York, USA.
Swingle D; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, New York, USA; PhD. Program in Biochemistry, The Graduate Center - City University of New York, New York, New York, USA.
Toy K; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, New York, USA; Department of Chemistry and Biochemistry, City College of New York, New York, New York, USA.
Edupuganti UR; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, New York, USA; PhD. Program in Biochemistry, The Graduate Center - City University of New York, New York, New York, USA.
Rivera-Cancel G; Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
Gardner KH; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, New York, USA; Department of Chemistry and Biochemistry, City College of New York, New York, New York, USA; PhD. Programs in Biochemistry, Biology, and Chemistry, The Graduate Center - City University of New York, New York, New York, USA. Electronic address: .
Pokaż więcej
Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Aug; Vol. 299 (8), pp. 104934. Date of Electronic Publication: 2023 Jun 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Bacterial Proteins*/metabolism
Histidine Kinase*/metabolism
Protein Multimerization*
Enzyme Activation
Czasopismo naukowe
Szczegóły
Tytuł:
Phosphatases maintain low catalytic activity of SGK1: DNA damage resets the balance in favor of phosphorylation.
Autorzy:
Gu W; School of Medicine, Tsinghua University, Beijing, China.
Zheng H; School of Medicine, Tsinghua University, Beijing, China.
Canessa CM; School of Medicine, Tsinghua University, Beijing, China; Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, USA. Electronic address: .
Pokaż więcej
Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Aug; Vol. 299 (8), pp. 104941. Date of Electronic Publication: 2023 Jun 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Damage*/genetics
Phosphoprotein Phosphatases*/metabolism
Protein Serine-Threonine Kinases*/metabolism
Phosphorylation ; Cell Line, Tumor ; Humans ; Enzyme Activation/physiology ; Cell Survival
Czasopismo naukowe
Szczegóły
Tytuł:
Identification and characterization of aptameric inhibitors of human neutrophil elastase.
Autorzy:
Malicki S; Laboratory of Proteolysis and Post-translational Modification of Proteins, Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland. Electronic address: .
Książek M; Laboratory of Proteolysis and Post-translational Modification of Proteins, Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Sochaj Gregorczyk A; Laboratory of Proteolysis and Post-translational Modification of Proteins, Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Kamińska M; Broegelmann Research Laboratory, University of Bergen, Bergen, Norway.
Golda A; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Chruścicka B; Laboratory of Proteolysis and Post-translational Modification of Proteins, Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Mizgalska D; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Potempa J; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland; Department of Oral Immunity and Infectious Diseases, University of Louisville School of Dentistry, Louisville, Kentucky, USA.
Marti HP; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Kozieł J; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Wieczorek M; Innovative Drugs R&D Department, Celon Pharma Inc, Lomianki, Poland.
Pieczykolan J; Innovative Drugs R&D Department, Celon Pharma Inc, Lomianki, Poland.
Mydel P; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland; Broegelmann Research Laboratory, University of Bergen, Bergen, Norway.
Dubin G; Protein Crystallography Research, Group Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.
Pokaż więcej
Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Aug; Vol. 299 (8), pp. 104889. Date of Electronic Publication: 2023 Jun 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Leukocyte Elastase*/antagonists & inhibitors
Serine Proteinase Inhibitors*/chemical synthesis
Serine Proteinase Inhibitors*/pharmacology
Serine Proteinase Inhibitors*/therapeutic use
Aptamers, Nucleotide*/chemical synthesis
Aptamers, Nucleotide*/pharmacology
Aptamers, Nucleotide*/therapeutic use
Humans ; Cystic Fibrosis/drug therapy ; Emphysema/drug therapy ; Neutrophils/drug effects ; Sensitivity and Specificity ; Enzyme Activation/drug effects ; Proteolysis/drug effects ; Cells, Cultured
Czasopismo naukowe
Szczegóły
Tytuł:
Organophosphate Level Evaluation for the Poisoning Treatment by Enzyme Activation Regeneration Strategy with Oxime-Functionalized ZIF-8 Nanoparticles.
Autorzy:
Shen A; Department of Chemistry and Chemical Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Hao X; Department of Chemistry and Chemical Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Li M; Department of Chemistry and Chemical Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Zhao Y; Department of Chemistry and Chemical Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Li Z; Department of Chemistry and Chemical Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Hou L; Department of Chemistry and Chemical Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Duan R; Department of Chemistry and Chemical Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Zhang P; Department of Chemistry and Chemical Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Zhang L; Department of Chemistry and Chemical Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.; State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization, Baotou Research Institute of Rare Earths, Baotou 014030, P.R. China.
Yang Y; Department of Chemistry and Chemical Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Pokaż więcej
Źródło:
Analytical chemistry [Anal Chem] 2023 Jul 11; Vol. 95 (27), pp. 10376-10383. Date of Electronic Publication: 2023 Jun 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Nerve Agents*
Nanoparticles*
Butyrylcholinesterase ; Oximes ; Organophosphates ; Enzyme Activation
Czasopismo naukowe
Szczegóły
Tytuł:
Pan-KRAS inhibitor disables oncogenic signalling and tumour growth.
Autorzy:
Kim D; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Herdeis L; Boehringer Ingelheim, Vienna, Austria.
Rudolph D; Boehringer Ingelheim, Vienna, Austria.
Zhao Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Böttcher J; Boehringer Ingelheim, Vienna, Austria.
Vides A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ayala-Santos CI; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Pourfarjam Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cuevas-Navarro A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Xue JY; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mantoulidis A; Boehringer Ingelheim, Vienna, Austria.
Bröker J; Boehringer Ingelheim, Vienna, Austria.
Wunberg T; Boehringer Ingelheim, Vienna, Austria.
Schaaf O; Boehringer Ingelheim, Vienna, Austria.
Popow J; Boehringer Ingelheim, Vienna, Austria.
Wolkerstorfer B; Boehringer Ingelheim, Vienna, Austria.
Kropatsch KG; Boehringer Ingelheim, Vienna, Austria.
Qu R; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
de Stanchina E; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sang B; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Li C; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
McConnell DB; Boehringer Ingelheim, Vienna, Austria.
Kraut N; Boehringer Ingelheim, Vienna, Austria.
Lito P; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. .
Pokaż więcej
Źródło:
Nature [Nature] 2023 Jul; Vol. 619 (7968), pp. 160-166. Date of Electronic Publication: 2023 May 31.
Typ publikacji:
Journal Article
MeSH Terms:
Neoplasms*/drug therapy
Neoplasms*/genetics
Neoplasms*/pathology
Proto-Oncogene Proteins p21(ras)*/antagonists & inhibitors
Proto-Oncogene Proteins p21(ras)*/genetics
Proto-Oncogene Proteins p21(ras)*/metabolism
Signal Transduction*/drug effects
Animals ; Mice ; Body Weight ; Enzyme Activation ; Mutation ; Nucleotides/metabolism ; Cell Division/drug effects ; Substrate Specificity
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 66122

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies