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Wyświetlanie 1-20 z 61707
Tytuł:
Unlocking the secrets to Janus kinase activation.
Autorzy:
Levine RL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Hubbard SR; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Apr 08; Vol. 376 (6589), pp. 139-140. Date of Electronic Publication: 2022 Apr 07.
Typ publikacji:
Journal Article; Comment
MeSH Terms:
Drug Development*
Enzyme Activation*
Janus Kinase 2*
Janus Kinases*
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1.
Autorzy:
Zou Y; The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Zheng Q; Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Zhejiang University, Hangzhou, 310009, China.
Jiang B; Department of Thoracic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.
Liu Y; Department of Thoracic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.
Xu Y; The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Ma L; Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Zhejiang University, Hangzhou, 310009, China.
Hu Z; The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Wu M; Department of Thoracic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China. .
Song H; The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, China. .; Department of Thoracic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China. .
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Źródło:
Cell death & disease [Cell Death Dis] 2022 Jul 16; Vol. 13 (7), pp. 618. Date of Electronic Publication: 2022 Jul 16.
Typ publikacji:
Journal Article
MeSH Terms:
MAP Kinase Kinase Kinases*/metabolism
Necroptosis*
Phosphoprotein Phosphatases*/deficiency
Phosphoprotein Phosphatases*/metabolism
Protein Kinases*/metabolism
Animals ; Apoptosis/genetics ; Enzyme Activation ; Inflammation/metabolism ; Mice ; Phosphorylation ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude.
Autorzy:
Ju J; Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea.
Lee HN; Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Department of Converging Science and Technology, Kyung Hee University, Seoul 02453, Republic of Korea.
Ning L; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA.
Ryu H; Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.
Zhou XX; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA.
Chun H; Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.
Lee YW; Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.
Lee-Richerson AI; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Jeong C; Center for Theragnosis, Korea Institute of Science and Technology, Seoul 02792, South Korea.
Lin MZ; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA. Electronic address: .
Seong J; Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea; Department of Converging Science and Technology, Kyung Hee University, Seoul 02453, Republic of Korea; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA. Electronic address: .
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Źródło:
Cell reports [Cell Rep] 2022 Jul 12; Vol. 40 (2), pp. 111080.
Typ publikacji:
Journal Article
MeSH Terms:
Guanine Nucleotide Exchange Factors*/metabolism
rhoA GTP-Binding Protein*/metabolism
Enzyme Activation ; Focal Adhesions/metabolism ; Rho Guanine Nucleotide Exchange Factors/metabolism ; Signal Transduction
Czasopismo naukowe
Szczegóły
Tytuł:
α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation.
Autorzy:
Chen JY; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China.
Zhu Q; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China.
Cai CZ; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China.
Luo HB; Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, Hainan 570228, China. Electronic address: .
Lu JH; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China. Electronic address: .
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Źródło:
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2022 Jul; Vol. 101, pp. 154125. Date of Electronic Publication: 2022 Apr 25.
Typ publikacji:
Journal Article
MeSH Terms:
Neurodegenerative Diseases*/metabolism
Parkinson Disease*/metabolism
Phosphodiesterase 4 Inhibitors*/metabolism
Phosphodiesterase 4 Inhibitors*/pharmacology
Cyclic AMP-Dependent Protein Kinases/*metabolism
Animals ; Dopaminergic Neurons/metabolism ; Enzyme Activation/drug effects ; Humans ; Mice ; Mice, Transgenic ; Proteasome Endopeptidase Complex/metabolism ; Rats ; Ubiquitin/metabolism ; Xanthones ; alpha-Synuclein/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Autorzy:
Michel M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Benítez-Buelga C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.; Instituto de Investigaciones Biomédicas Alberto Sols (CSIC/UAM), 28029 Madrid, Spain.
Calvo PA; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), 28049 Madrid, Spain.
Hanna BMF; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Mortusewicz O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Masuyer G; Department of Pharmacy and Pharmacology, Centre for Therapeutic Innovation, University of Bath, Bath BA2 7AY, UK.; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden.
Davies J; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden.
Wallner O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Sanjiv K; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Albers JJ; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Castañeda-Zegarra S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Jemth AS; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Visnes T; Department of Biotechnology and Nanomedicine, SINTEF Industry, N-7465 Trondheim, Norway.
Sastre-Perona A; Experimental Therapies and Novel Biomarkers in Cancer, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
Danda AN; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Homan EJ; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Marimuthu K; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Zhenjun Z; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Chi CN; Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Sarno A; Department of Environment and New Resources, SINTEF Ocean, N-7496 Trondheim, Norway.
Wiita E; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
von Nicolai C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Komor AJ; Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Department of Biomolecular Chemistry, 07745 Jena, Germany.
Rajagopal V; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Müller S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Hank EC; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Varga M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Scaletti ER; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden.; Department of Experimental Medical Science, Lund University, Lund, Sweden.
Pandey M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.; Sheffield Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK.
Karsten S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Haslene-Hox H; Department of Biotechnology and Nanomedicine, SINTEF Industry, N-7465 Trondheim, Norway.
Loevenich S; Department of Biotechnology and Nanomedicine, SINTEF Industry, N-7465 Trondheim, Norway.
Marttila P; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Rasti A; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Mamonov K; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Ortis F; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Schömberg F; Institute of Organic and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany.
Loseva O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Stewart J; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
D'Arcy-Evans N; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Koolmeister T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Henriksson M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Michel D; Chemical Processes and Pharmaceutical Development, Unit Process Chemistry I, Research Institutes of Sweden - RISE, 151 36 Södertälje, Sweden.
de Ory A; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden.
Acero L; Experimental Therapies and Novel Biomarkers in Cancer, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
Calvete O; Familial Cancer Clinical Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
Scobie M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Hertweck C; Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Department of Biomolecular Chemistry, 07745 Jena, Germany.; Institute of Microbiology, Friedrich-Schiller-University Jena, 07743 Jena, Germany.
Vilotijevic I; Institute of Organic and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany.
Kalderén C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
Osorio A; Familial Cancer Clinical Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Perona R; Instituto de Investigaciones Biomédicas Alberto Sols (CSIC/UAM), 28029 Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Stolz A; Institute of Biochemistry II and Buchmann Institute for Molecular Life Science, Goethe University Frankfurt, 60590 Frankfurt, Germany.
Stenmark P; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden.; Department of Experimental Medical Science, Lund University, Lund, Sweden.
Berglund UW; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
de Vega M; Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), 28049 Madrid, Spain.
Helleday T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.; Sheffield Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Jun 24; Vol. 376 (6600), pp. 1471-1476. Date of Electronic Publication: 2022 Jun 23.
Typ publikacji:
Journal Article
MeSH Terms:
DNA Damage*/drug effects
DNA Glycosylases*/chemistry
DNA Glycosylases*/drug effects
DNA Repair*/drug effects
Oxidative Stress*/genetics
Biocatalysis/drug effects ; Enzyme Activation ; Glycine/chemistry ; Humans ; Ligands ; Phenylalanine/chemistry ; Substrate Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes.
Autorzy:
Siraliev-Perez E; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Stariha JTB; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
Hoffmann RM; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
Temple BRS; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Zhang Q; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United States.; Division of Chemical Biology and Medicinal Chemistry, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.; Lineberger Comprehensive Cancer Center, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Hajicek N; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Jenkins ML; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
Burke JE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, Canada.
Sondek J; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United States.; Lineberger Comprehensive Cancer Center, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, United States.; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, United States.
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Źródło:
ELife [Elife] 2022 Jun 16; Vol. 11. Date of Electronic Publication: 2022 Jun 16.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Isoenzymes*/metabolism
Type C Phospholipases*/metabolism
Allosteric Regulation ; Enzyme Activation ; Lipase/metabolism ; Lipids ; Phospholipase C gamma/metabolism ; Phosphorylation
Czasopismo naukowe
Szczegóły
Tytuł:
Mechanistic insights into the activation of the IKK kinase complex by the Kaposi's sarcoma herpes virus oncoprotein vFLIP.
Autorzy:
Bagnéris C; Department of Biological Sciences, Institute of Structural Molecular Biology, Birkbeck College, London, UK.
Senthil Kumar SL; Department of Biological Sciences, Institute of Structural Molecular Biology, Birkbeck College, London, UK.
Baratchian M; Genitourinary Malignancies Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Britt HM; Division of Biosciences, Institute of Structural and Molecular Biology, University College London, London, UK.
Assafa TE; Chemistry and Biochemistry Department, University of California Santa Cruz, Santa Cruz, California, USA.
Thalassinos K; Department of Biological Sciences, Institute of Structural Molecular Biology, Birkbeck College, London, UK; Division of Biosciences, Institute of Structural and Molecular Biology, University College London, London, UK.
Collins MK; Okinawa Institute of Science and Technology, Graduate University, Onna-son, Okinawa, Japan.
Barrett TE; Department of Biological Sciences, Institute of Structural Molecular Biology, Birkbeck College, London, UK. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2022 Jun; Vol. 298 (6), pp. 102012. Date of Electronic Publication: 2022 May 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Herpesvirus 8, Human*/genetics
Herpesvirus 8, Human*/metabolism
Sarcoma, Kaposi*/enzymology
Sarcoma, Kaposi*/virology
Enzyme Activation/genetics ; Humans ; I-kappa B Kinase/metabolism ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Oncogene Proteins/metabolism ; Viral Proteins/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Phosphorylation at Ser of the ER stress sensor IRE1α governs its activation state and limits ER stress-induced hepatosteatosis.
Autorzy:
Li Y; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Frontier Science Center for Immunology and Metabolism, and the Institute for Advanced Studies, Wuhan University, Wuhan, China.
Huang S; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Frontier Science Center for Immunology and Metabolism, and the Institute for Advanced Studies, Wuhan University, Wuhan, China.
Wang J; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Frontier Science Center for Immunology and Metabolism, and the Institute for Advanced Studies, Wuhan University, Wuhan, China.
Dai J; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Cai J; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Frontier Science Center for Immunology and Metabolism, and the Institute for Advanced Studies, Wuhan University, Wuhan, China.
Yan S; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, Hubei, China.
Huang Z; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, Hubei, China.
He S; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Frontier Science Center for Immunology and Metabolism, and the Institute for Advanced Studies, Wuhan University, Wuhan, China.
Wang P; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, Hubei, China.
Liu J; Cellular Signaling Laboratory, Key Laboratory of Molecular Biophysics of Ministry of Education, Huazhong University of Science and Technology, Wuhan, China.
Liu Y; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Frontier Science Center for Immunology and Metabolism, and the Institute for Advanced Studies, Wuhan University, Wuhan, China. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2022 Jun; Vol. 298 (6), pp. 101997. Date of Electronic Publication: 2022 Apr 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endoplasmic Reticulum Stress*/genetics
Endoribonucleases*/genetics
Endoribonucleases*/metabolism
Protein Serine-Threonine Kinases*/genetics
Protein Serine-Threonine Kinases*/metabolism
Animals ; Enzyme Activation ; Fatty Liver/genetics ; Fibroblasts/metabolism ; Mice ; Mutation ; Phosphorylation ; Signal Transduction/genetics ; X-Box Binding Protein 1/genetics ; X-Box Binding Protein 1/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways.
Autorzy:
Delgado M; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Rainwater RR; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Heflin B; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Urbaniak A; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Butler K; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Davidson M; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Protacio RM; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Baldini G; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Edwards A; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Reed MR; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Raney KD; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Chambers TC; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2022 Jun; Vol. 298 (6), pp. 101939. Date of Electronic Publication: 2022 Apr 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Apoptosis*/drug effects
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/metabolism
Vincristine*/metabolism
Vincristine*/pharmacology
Vincristine*/therapeutic use
Caspase 3/metabolism ; Cell Cycle ; Enzyme Activation/drug effects ; Humans ; Microtubules/drug effects ; Microtubules/metabolism ; Mitosis/drug effects ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
A novel AMPK activator shows therapeutic potential in hepatocellular carcinoma by suppressing HIF1α-mediated aerobic glycolysis.
Autorzy:
Tseng HI; Department of Pharmacy, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Zeng YS; Department of Pharmacy, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department & Institute of Physiology, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Lin YJ; Department of Life Science and Institute of Plant Biology, National Taiwan University, Taipei, Taiwan.; Genome and Systems Biology Degree Program, National Taiwan University and Academia Sinica, Taipei, Taiwan.
Huang JW; Biomedical Technology and Device Research Labs, Industrial Technology Research Institute, Hsinchu, Taiwan.
Lin CL; Biomedical Technology and Device Research Labs, Industrial Technology Research Institute, Hsinchu, Taiwan.
Lee MH; Department of Pharmacy, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yang FW; Department of Pharmacy, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Fang TP; Department of Pharmacy, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Mar AC; Taiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, Taiwan.
Su JC; Department of Pharmacy, National Yang Ming Chiao Tung University, Taipei, Taiwan.
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Źródło:
Molecular oncology [Mol Oncol] 2022 Jun; Vol. 16 (11), pp. 2274-2294. Date of Electronic Publication: 2022 Apr 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
AMP-Activated Protein Kinases*/metabolism
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Carcinoma, Hepatocellular*/drug therapy
Carcinoma, Hepatocellular*/enzymology
Glycolysis*/drug effects
Liver Neoplasms*/drug therapy
Liver Neoplasms*/enzymology
Cell Line, Tumor ; Enzyme Activation ; Humans ; Signal Transduction
Czasopismo naukowe
Szczegóły
Tytuł:
Selective phosphorylation of serine 345 on p47-phox serves as a priming signal of ROS-mediated axonal degeneration.
Autorzy:
Wakatsuki S; Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi, Kodaira, Tokyo 187-8502, Japan. Electronic address: .
Takahashi Y; Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi, Kodaira, Tokyo 187-8502, Japan.
Shibata M; Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi, Kodaira, Tokyo 187-8502, Japan.
Araki T; Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi, Kodaira, Tokyo 187-8502, Japan. Electronic address: .
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Źródło:
Experimental neurology [Exp Neurol] 2022 Jun; Vol. 352, pp. 114024. Date of Electronic Publication: 2022 Feb 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
NADPH Oxidases*/metabolism
Serine*/metabolism
Enzyme Activation ; ErbB Receptors/metabolism ; Oxazoles ; Phosphoproteins/metabolism ; Phosphorylation ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Structure and activation mechanism of the human liver-type glutaminase GLS2.
Autorzy:
Ferreira IM; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, Sao Paulo, Zip Code, 13083-970, Brazil.
Quesñay JEN; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, Sao Paulo, Zip Code, 13083-970, Brazil; Sao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, SP, Zip Code, 13563-120, Brazil.
Bastos AC; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, Sao Paulo, Zip Code, 13083-970, Brazil; Graduate Program in Genetics and Molecular Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Rodrigues CT; Sao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, SP, Zip Code, 13563-120, Brazil.
Vollmar M; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK.
Krojer T; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK.
Strain-Damerell C; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK; Diamond Light Source Ltd., The Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0FA, UK.
Burgess-Brown NA; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK.
von Delft F; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK; Diamond Light Source Ltd., The Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0FA, UK; Department of Biochemistry, University of Johannesburg, Auckland Park, 2006, South Africa; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot, OX11 0FA, UK.
Yue WW; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, OX3 7DQ, UK. Electronic address: .
Dias SM; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, Sao Paulo, Zip Code, 13083-970, Brazil. Electronic address: .
Ambrosio AL; Brazilian Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, Sao Paulo, Zip Code, 13083-970, Brazil; Sao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, SP, Zip Code, 13563-120, Brazil. Electronic address: .
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Źródło:
Biochimie [Biochimie] 2021 Jun; Vol. 185, pp. 96-104. Date of Electronic Publication: 2021 Mar 18.
Typ publikacji:
Journal Article
MeSH Terms:
Enzyme Activation*
Glutaminase/*chemistry
Liver/*enzymology
Amino Acid Substitution ; Catalysis ; Glutaminase/genetics ; Glutaminase/metabolism ; Humans ; Mutation, Missense ; Protein Structure, Quaternary ; Structure-Activity Relationship
Czasopismo naukowe
Szczegóły
Tytuł:
Novel indolic AMPK modulators induce vasodilatation through activation of the AMPK–eNOS–NO pathway.
Autorzy:
Sanz-Gómez, Marta (AUTHOR)
Aledavood, Elnaz (AUTHOR)
Beroiz-Salaverri, Marina (AUTHOR)
Lagartera, Laura (AUTHOR)
Vega-Martín, Elena (AUTHOR)
Gil-Ortega, Marta (AUTHOR)
Cumella, Jose (AUTHOR)
Pérez, Concepción (AUTHOR)
Luque, Francisco Javier (AUTHOR)
Estarellas, Carolina (AUTHOR)
Fernández-Alfonso, María S. (AUTHOR)
Castro, Ana (AUTHOR)
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Źródło:
Scientific Reports. 3/10/2022, Vol. 12 Issue 1, p1-15. 15p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cobalt Regulates Activation of Camk2α in Neurons by Influencing Fructose 1,6-bisphosphatase 2 Quaternary Structure and Subcellular Localization.
Autorzy:
Duda P; Department of Molecular Physiology and Neurobiology, University of Wrocław, 50-335 Wrocław, Poland.
Budziak B; Department of Molecular Physiology and Neurobiology, University of Wrocław, 50-335 Wrocław, Poland.
Rakus D; Department of Molecular Physiology and Neurobiology, University of Wrocław, 50-335 Wrocław, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 30; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 30.
Typ publikacji:
Journal Article
MeSH Terms:
Enzyme Activation*
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism
Cobalt/*metabolism
Neurons/*metabolism
Animals ; Cells, Cultured ; Gene Silencing ; Mice, Inbred C57BL ; Neurons/cytology ; Protein Interaction Maps ; Protein Structure, Quaternary
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Activation of Focal Adhesion Kinase Restores Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation via Wnt/Β-Catenin Pathway.
Autorzy:
Fan C; Cancer Research, Saskatchewan Cancer Agency, Saskatoon, SK S7N 4H4, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.; School of Life Sciences, Beijing Institute of Technology, Beijing 100811, China.
Wu Z; Cancer Research, Saskatchewan Cancer Agency, Saskatoon, SK S7N 4H4, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Cooper DML; Department of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Magnus A; Department of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Harrison K; Department of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Eames BF; Department of Anatomy, Physiology and Pharmacology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Chibbar R; Department of Pathology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Groot G; Department of Surgery, Royal University Hospital, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Huang J; Department of Blood Transfusion, Affiliated Hospital of Zunyi Medical University, Zunyi 563006, China.
Genth H; Institute of Toxicology, Hannover Medical School, D-30625 Hannover, Germany.
Zhang J; School of Life Sciences, Beijing Institute of Technology, Beijing 100811, China.
Tan X; School of Life Sciences, Beijing Institute of Technology, Beijing 100811, China.
Deng Y; School of Life Sciences, Beijing Institute of Technology, Beijing 100811, China.
Xiang J; Cancer Research, Saskatchewan Cancer Agency, Saskatoon, SK S7N 4H4, Canada.; Department of Oncology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 May 17; Vol. 23 (10). Date of Electronic Publication: 2022 May 17.
Typ publikacji:
Journal Article
MeSH Terms:
Focal Adhesion Protein-Tyrosine Kinases*/metabolism
Osteoblasts*/cytology
Osteoblasts*/metabolism
Weightlessness*
Wnt Signaling Pathway*
beta Catenin*/metabolism
3T3 Cells ; Animals ; Enzyme Activation ; Focal Adhesion Kinase 1/metabolism ; Mice ; X-Ray Microtomography
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An Integrated Pharmacological, Structural, and Genetic Analysis of Extracellular Versus Intracellular ROS Production in Neutrophils.
Autorzy:
Ellson CD; Departments of Biology and Biological Engineering, and Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA.
Riça IG; Departments of Biology and Biological Engineering, and Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA.
Kim JS; Departments of Biology and Biological Engineering, and Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA.
Huang YM; Department of Chemistry, University of California, Riverside CA92521, USA.
Lim D; Departments of Biology and Biological Engineering, and Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA.
Mitra T; Departments of Biology and Biological Engineering, and Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA.
Hsu A; Departments of Biology and Biological Engineering, and Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA.
Wei EX; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215 USA.
Barrett CD; Departments of Biology and Biological Engineering, and Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA. Electronic address: https://twitter.com/ChrisBarrettMD.
Otterbein LE; Divisions of Acute Care Surgery, Trauma, and Surgical Critical Care, and Surgical Oncology, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 USA.
Hauser CJ; Divisions of Acute Care Surgery, Trauma, and Surgical Critical Care, and Surgical Oncology, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 USA.
Wahl M; Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Delbrück H; Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Heinemann U; Chemistry and Biochemistry Institute, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany; Divisions of Acute Care Surgery, Trauma, and Surgical Critical Care, and Surgical Oncology, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 USA.
Oschkinat H; Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125 Berlin, Germany; Chemistry and Biochemistry Institute, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany.
Chang CA; Department of Chemistry, University of California, Riverside CA92521, USA. Electronic address: https://twitter.com/ChiaenChang1.
Yaffe MB; Departments of Biology and Biological Engineering, and Center for Precision Cancer Medicine, David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, MA 02139, USA; Divisions of Acute Care Surgery, Trauma, and Surgical Critical Care, and Surgical Oncology, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 USA. Electronic address: .
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Źródło:
Journal of molecular biology [J Mol Biol] 2022 May 15; Vol. 434 (9), pp. 167533. Date of Electronic Publication: 2022 Mar 18.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Class I Phosphatidylinositol 3-Kinases*/metabolism
NADPH Oxidases*/genetics
NADPH Oxidases*/metabolism
Neutrophils*/enzymology
Reactive Oxygen Species*/metabolism
Animals ; Enzyme Activation ; Inflammation ; Mice ; Signal Transduction
Czasopismo naukowe
Szczegóły
Tytuł:
FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells.
Autorzy:
Zhang Y; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Xiong X; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Zhu Q; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Zhang J; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Chen S; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Wang Y; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Cao J; Department of Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China.
Chen L; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Hou L; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Zhao X; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Hao P; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Chen J; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Zhuang M; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Li D; Department of Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China.
Fan G; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
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Źródło:
ELife [Elife] 2022 May 12; Vol. 11. Date of Electronic Publication: 2022 May 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Insulin Receptor Substrate Proteins*/metabolism
Ovarian Neoplasms*/metabolism
Phosphatidylinositol 3-Kinases*/metabolism
Protein-Tyrosine Kinases*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Carcinogenesis ; Carcinoma, Ovarian Epithelial/metabolism ; Cell Transformation, Neoplastic ; Enzyme Activation ; Female ; Humans ; Phosphorylation ; Tyrosine/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
TAB1 binding induced p38α conformation change: an accelerated molecular dynamics simulation study.
Autorzy:
Zang Y; MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China. .
Wang H; MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China. .
Kang Y; MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China. .
Zhang J; MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China. .
Li X; MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China. .
Zhang L; MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China. .
Yang Z; MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China. .
Zhang S; MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiaotong University, Xi'an 710049, China. .
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Źródło:
Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2022 May 04; Vol. 24 (17), pp. 10506-10513. Date of Electronic Publication: 2022 May 04.
Typ publikacji:
Journal Article
MeSH Terms:
Mitogen-Activated Protein Kinase 14*/chemistry
Mitogen-Activated Protein Kinase 14*/metabolism
Myocardial Ischemia*
Adaptor Proteins, Signal Transducing/metabolism ; Amino Acid Sequence ; Enzyme Activation ; Humans ; Molecular Dynamics Simulation ; Phosphorylation ; Protein Binding
Czasopismo naukowe
Szczegóły
Tytuł:
E3 ligases and deubiquitinating enzymes regulating the MAPK signaling pathway in cancers.
Autorzy:
Park HB; Department of Biomedical Science, CHA University, Gyeonggi-Do 13488, Republic of Korea.
Baek KH; Department of Biomedical Science, CHA University, Gyeonggi-Do 13488, Republic of Korea. Electronic address: .
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Źródło:
Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2022 May; Vol. 1877 (3), pp. 188736. Date of Electronic Publication: 2022 May 16.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Deubiquitinating Enzymes*/metabolism
Mitogen-Activated Protein Kinase Kinases*/metabolism
Neoplasms*/metabolism
Ubiquitin-Protein Ligases*/metabolism
Enzyme Activation ; Humans ; Signal Transduction/physiology ; Ubiquitin/metabolism
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 61707

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