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Wyświetlanie 1-20 z 27409
Tytuł:
Nitrite Attenuates the In Vitro Inflammatory Response of Immune Cells to the SARS-CoV-2 S Protein without Interfering in the Antioxidant Enzyme Activation.
Autorzy:
Ferrer, Miguel D. (AUTHOR)
Reynés, Clara (AUTHOR)
Jiménez, Laura (AUTHOR)
Malagraba, Gianluca (AUTHOR)
Monserrat-Mesquida, Margalida (AUTHOR)
Bouzas, Cristina (AUTHOR)
Sureda, Antoni (AUTHOR)
Tur, Josep A. (AUTHOR)
Pons, Antoni (AUTHOR)
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Źródło:
International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 5, p3001. 15p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Integration of (S)-2,3-oxidosqualene enables E. coli to become Iron Man E. coli with improved overall tolerance.
Autorzy:
Sun, Wenjie (AUTHOR)
Chen, Yun (AUTHOR)
Li, Mengkun (AUTHOR)
Shah, Syed Bilal (AUTHOR)
Wang, Tianfu (AUTHOR)
Hou, Jin (AUTHOR)
Bai, Linquan (AUTHOR)
Feng, Yan (AUTHOR)
Tan, Zaigao (AUTHOR)
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Źródło:
Biotechnology for Biofuels & Bioproducts. 12/10/2023, Vol. 16 Issue 1, p1-14. 14p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity.
Autorzy:
Lelyveld VS; Center for Computational and Integrative Biology, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Fang Z; Center for Computational and Integrative Biology, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.
Szostak JW; Center for Computational and Integrative Biology, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.; Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Oct 27; Vol. 382 (6669), pp. 423-429. Date of Electronic Publication: 2023 Oct 26.
Typ publikacji:
Journal Article
MeSH Terms:
Calcium*/chemistry
DNA*/biosynthesis
DNA-Directed DNA Polymerase*/chemistry
Coenzymes*/chemistry
Geobacillus stearothermophilus*/enzymology
Bacterial Proteins*/chemistry
Nucleotides/chemistry ; Enzyme Activation ; Crystallography, X-Ray ; Protein Conformation ; Biocatalysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation.
Autorzy:
Juyoux P; European Molecular Biology Laboratory (EMBL), Grenoble, France.
Galdadas I; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Gobbo D; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
von Velsen J; European Molecular Biology Laboratory (EMBL), Grenoble, France.
Pelosse M; European Molecular Biology Laboratory (EMBL), Grenoble, France.
Tully M; European Synchrotron Radiation Facility, Grenoble, France.
Vadas O; Protein and peptide purification platform, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Gervasio FL; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.; School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.; Department of Chemistry, University College London, London, UK.; Institute of Structural and Molecular Biology, University College London, London, UK.; Swiss Institute of Bioinformatics, Geneva, Switzerland.
Pellegrini E; European Molecular Biology Laboratory (EMBL), Grenoble, France.
Bowler MW; European Molecular Biology Laboratory (EMBL), Grenoble, France.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Sep 15; Vol. 381 (6663), pp. 1217-1225. Date of Electronic Publication: 2023 Sep 14.
Typ publikacji:
Journal Article
MeSH Terms:
MAP Kinase Kinase 2*/chemistry
MAP Kinase Kinase 6*/chemistry
Mitogen-Activated Protein Kinase 14*/chemistry
Cryoelectron Microscopy ; Enzyme Activation ; Phosphorylation ; Substrate Specificity ; Protein Conformation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unlocking the secrets to Janus kinase activation.
Autorzy:
Levine RL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Hubbard SR; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Apr 08; Vol. 376 (6589), pp. 139-140. Date of Electronic Publication: 2022 Apr 07.
Typ publikacji:
Journal Article; Comment
MeSH Terms:
Drug Development*
Enzyme Activation*
Janus Kinase 2*
Janus Kinases*
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cobalt Regulates Activation of Camk2α in Neurons by Influencing Fructose 1,6-bisphosphatase 2 Quaternary Structure and Subcellular Localization.
Autorzy:
Duda P; Department of Molecular Physiology and Neurobiology, University of Wrocław, 50-335 Wrocław, Poland.
Budziak B; Department of Molecular Physiology and Neurobiology, University of Wrocław, 50-335 Wrocław, Poland.
Rakus D; Department of Molecular Physiology and Neurobiology, University of Wrocław, 50-335 Wrocław, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 30; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 30.
Typ publikacji:
Journal Article
MeSH Terms:
Enzyme Activation*
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism
Cobalt/*metabolism
Neurons/*metabolism
Animals ; Cells, Cultured ; Gene Silencing ; Mice, Inbred C57BL ; Neurons/cytology ; Protein Interaction Maps ; Protein Structure, Quaternary ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A massive machine regulates cell death.
Autorzy:
Mace PD; Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Day CL; Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Mar 17; Vol. 379 (6637), pp. 1093-1094. Date of Electronic Publication: 2023 Mar 16.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Inhibitor of Apoptosis Proteins*/chemistry
Inhibitor of Apoptosis Proteins*/metabolism
Caspases/metabolism ; Enzyme Activation ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
Autorzy:
Hunkeler M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Jin CY; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Mar 17; Vol. 379 (6637), pp. 1105-1111. Date of Electronic Publication: 2023 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Caspases*/chemistry
Caspases*/metabolism
Inhibitor of Apoptosis Proteins*/chemistry
Inhibitor of Apoptosis Proteins*/metabolism
Mitochondrial Proteins*/chemistry
Mitochondrial Proteins*/metabolism
Apoptosis Regulatory Proteins*/chemistry
Apoptosis Regulatory Proteins*/metabolism
Animals ; Humans ; Cryoelectron Microscopy ; Enzyme Activation ; High-Temperature Requirement A Serine Peptidase 2/chemistry ; High-Temperature Requirement A Serine Peptidase 2/metabolism ; Protein Domains
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Activation of L-lactate oxidase by the formation of enzyme assemblies through liquid–liquid phase separation.
Autorzy:
Ura, Tomoto (AUTHOR)
Kagawa, Ako (AUTHOR)
Sakakibara, Nanako (AUTHOR)
Yagi, Hiromasa (AUTHOR)
Tochio, Naoya (AUTHOR)
Kigawa, Takanori (AUTHOR)
Shiraki, Kentaro (AUTHOR)
Mikawa, Tsutomu (AUTHOR)
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Źródło:
Scientific Reports. 1/25/2023, Vol. 13 Issue 1, p1-9. 9p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Functional mechanism of AMPK activation in mitochondrial regeneration of rat peritoneal macrophages mediated by uremic serum.
Autorzy:
Chen; Department of Critical Care Medcine, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, China.
Zuo K; Department of Critical Care Medcine, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, China.
Liang X; Department of Critical Care Medcine, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, China.
Wang M; Department of Critical Care Medcine, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, China.
Zhang H; Department of Critical Care Medcine, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, China.
Zhou R; Department of Critical Care Medcine, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, China.
Liu X; Department of Critical Care Medcine, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, China.
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Źródło:
PloS one [PLoS One] 2020 Sep 28; Vol. 15 (9), pp. e0235960. Date of Electronic Publication: 2020 Sep 28 (Print Publication: 2020).
Typ publikacji:
Journal Article
MeSH Terms:
Enzyme Activation*
AMP-Activated Protein Kinases/*metabolism
Macrophages, Peritoneal/*metabolism
Mitochondria/*metabolism
Uremia/*metabolism
Animals ; Macrophages, Peritoneal/pathology ; Male ; Mitochondria/pathology ; Mitochondrial Dynamics ; RNA, Messenger/metabolism ; RNA, Mitochondrial/metabolism ; Rats ; Rats, Sprague-Dawley ; Uremia/blood ; Uremia/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sirtuin-1 expression and activity is diminished in aged liver grafts.
Autorzy:
Scheuermann U; Department of Visceral, Transplantation, Vascular, and Thoracic Surgery, University Hospital of Leipzig, Leipzig, Germany.
Seyferth ER; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Abraham N; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Kesseli SJ; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Halpern SE; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Zhu M; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Song M; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Hartwig MG; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Parker W; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Kwun J; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Cherry AD; Department of Anesthesiology, Duke University, Durham, USA.
Lee J; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA.
Barbas AS; Department of Surgery, Duke University, DUMC 3512, Durham, NC, 27710, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jul 17; Vol. 10 (1), pp. 11860. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Enzyme Activation*
Gene Expression*
Liver Transplantation*
Organ Preservation*
Liver/*metabolism
Sirtuin 1/*genetics
Sirtuin 1/*metabolism
Animals ; Antioxidants/metabolism ; Biomarkers ; Cryopreservation ; Cytokines/metabolism ; Graft Survival ; Inflammation Mediators/metabolism ; Liver Function Tests ; Male ; Mitochondria/metabolism ; Models, Animal ; Oxygen Consumption ; Rats ; Reperfusion Injury ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 27409

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