Temat: "Enzyme Activation" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: RNA editing restricts hyperactive ciliary kinases.
Autorzy:: Li D; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.; Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China.; McGovern Institute for Brain Research, Tsinghua University, Beijing, China.; School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China.
Liu Y; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.; Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China.; McGovern Institute for Brain Research, Tsinghua University, Beijing, China.; School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China.
Yi P; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.; Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China.; McGovern Institute for Brain Research, Tsinghua University, Beijing, China.; School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China.
Zhu Z; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.; Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China.; McGovern Institute for Brain Research, Tsinghua University, Beijing, China.; School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China.
Li W; School of Medicine, Tsinghua University, Beijing, China.
Zhang QC; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.; Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China.; MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, China.; Center for Synthetic and Systems Biology, Tsinghua University, Beijing, China.
Li JB; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Ou G; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China. .; Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China.; McGovern Institute for Brain Research, Tsinghua University, Beijing, China.; School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2021 Aug 27; Vol. 373 (6558), pp. 984-991.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: RNA Editing*
Caenorhabditis elegans/*enzymology
Caenorhabditis elegans Proteins/*genetics
Caenorhabditis elegans Proteins/*metabolism
Cilia/*metabolism
Mitogen-Activated Protein Kinases/*genetics
Mitogen-Activated Protein Kinases/*metabolism
Adenosine Deaminase/genetics ; Adenosine Deaminase/metabolism ; Animals ; Caenorhabditis elegans/genetics ; Cell Nucleus/metabolism ; Cilia/enzymology ; Enzyme Activation ; Phenotype ; Protein Biosynthesis ; Protein Serine-Threonine Kinases/metabolism ; RNA Precursors/genetics ; RNA Precursors/metabolism ; RNA Splicing ; RNA Stability ; RNA, Antisense/genetics ; RNA, Antisense/metabolism ; RNA, Double-Stranded/genetics ; RNA, Double-Stranded/metabolism ; RNA, Helminth/genetics ; RNA, Helminth/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Signal Transduction ; Transcription, Genetic

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Skocz do pozycji: 2.

Tytuł:: Differential Role of Threonine and Tyrosine Phosphorylation in the Activation and Activity of the Yeast MAPK Slt2.
Autorzy:: González-Rubio G; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain.
Sellers-Moya Á; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain.
Martín H; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain.
Molina M; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jan 23; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 23.
Typ publikacji:: Journal Article
MeSH Terms:: Mitogen-Activated Protein Kinases/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Threonine/*metabolism
Tyrosine/*metabolism
Antibodies/metabolism ; Enzyme Activation ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Mitogen-Activated Protein Kinases/genetics ; Mitogen-Activated Protein Kinases/immunology ; Mutation ; Phosphorylation ; Protein Tyrosine Phosphatases/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/immunology

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Skocz do pozycji: 3.

Tytuł:: Betaine alleviates high glucose‑induced mesangial cell proliferation by inhibiting cell proliferation and extracellular matrix deposition via the AKT/ERK1/2/p38 MAPK pathway.
Autorzy:: Li X; Department of Traditional Chinese Medicine, Tianjin Key Laboratory of Artificial Cell, Tianjin Institute of Hepatobiliary Disease, Artificial Cell Engineering Technology Research Center of Public Health Ministry, Third Central Hospital of Tianjin, Tianjin 300170, P.R. China.
Wang L; Department of Basic Medicine, Tianjin Medical College, Tianjin 300222, P.R. China.
Ma H; Department of Traditional Chinese Medicine, Tianjin 4th Centre Hospital, Tianjin 300140, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2019 Aug; Vol. 20 (2), pp. 1754-1760. Date of Electronic Publication: 2019 Jun 18.
Typ publikacji:: Journal Article
MeSH Terms:: Betaine/*metabolism
Glucose/*metabolism
Mesangial Cells/*metabolism
Mitogen-Activated Protein Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Animals ; Cell Proliferation ; Cells, Cultured ; Diabetic Nephropathies/metabolism ; Enzyme Activation ; Extracellular Matrix/metabolism ; Mesangial Cells/cytology ; Mice ; Signal Transduction

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Skocz do pozycji: 4.

Tytuł:: Microwave diathermy induces mitogen-activated protein kinases and tumor necrosis factor-α in cultured human monocytes.
Autorzy:: Lagoumintzis G; a Laboratory of Health Physics, Department of Optics & Optometry and Department of Physiotherapy, Western Greece University of Applied Sciences (TEI of Western Greece) , Aigion , Greece.
Andrikopoulos A; a Laboratory of Health Physics, Department of Optics & Optometry and Department of Physiotherapy, Western Greece University of Applied Sciences (TEI of Western Greece) , Aigion , Greece.; b Laboratory of Medical Physics, School of Medicine , Democritus University of Thrace , Alexandroupolis , Greece.
Adamopoulos A; b Laboratory of Medical Physics, School of Medicine , Democritus University of Thrace , Alexandroupolis , Greece.
Seimenis I; b Laboratory of Medical Physics, School of Medicine , Democritus University of Thrace , Alexandroupolis , Greece.
Koutsojannis C; a Laboratory of Health Physics, Department of Optics & Optometry and Department of Physiotherapy, Western Greece University of Applied Sciences (TEI of Western Greece) , Aigion , Greece.; Pokaż więcej
Źródło:: Electromagnetic biology and medicine [Electromagn Biol Med] 2019; Vol. 38 (3), pp. 218-229. Date of Electronic Publication: 2019 May 11.
Typ publikacji:: Journal Article
MeSH Terms:: Diathermy*
Microwaves*
Mitogen-Activated Protein Kinases/*metabolism
Monocytes/*metabolism
Monocytes/*radiation effects
Tumor Necrosis Factor-alpha/*metabolism
Cell Line ; Cell Survival/radiation effects ; Enzyme Activation/radiation effects ; Humans ; Intracellular Space/metabolism ; Intracellular Space/radiation effects ; Monocytes/cytology

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Skocz do pozycji: 5.

Tytuł:: Transcriptomic analysis reveals that enterovirus F strain SWUN-AB001 infection activates JNK/SAPK and p38 MAPK signaling pathways in MDBK cells.
Autorzy:: Zhang B; College of Life Science and Technology, Southwest Minzu University, No.16, South 4th Section 1st Ring Road, Chengdu, 610041, China. .; Key laboratory of Ministry of Education and Sichuan Province for Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Chengdu, 610041, China. .; Animal Disease Prevention and Control Innovation Team in the Qinghai-Tibetan Plateau of State Ethnic Affairs Commission, Chengdu, 610041, China. .
Chen X; College of Life Science and Technology, Southwest Minzu University, No.16, South 4th Section 1st Ring Road, Chengdu, 610041, China.
Yue H; College of Life Science and Technology, Southwest Minzu University, No.16, South 4th Section 1st Ring Road, Chengdu, 610041, China.; Key laboratory of Ministry of Education and Sichuan Province for Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Chengdu, 610041, China.; Animal Disease Prevention and Control Innovation Team in the Qinghai-Tibetan Plateau of State Ethnic Affairs Commission, Chengdu, 610041, China.
Ruan W; College of Life Science and Technology, Southwest Minzu University, No.16, South 4th Section 1st Ring Road, Chengdu, 610041, China.
Qin S; College of Life Science and Technology, Southwest Minzu University, No.16, South 4th Section 1st Ring Road, Chengdu, 610041, China.
Tang C; College of Life Science and Technology, Southwest Minzu University, No.16, South 4th Section 1st Ring Road, Chengdu, 610041, China. .; Key laboratory of Ministry of Education and Sichuan Province for Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Chengdu, 610041, China. .; Animal Disease Prevention and Control Innovation Team in the Qinghai-Tibetan Plateau of State Ethnic Affairs Commission, Chengdu, 610041, China. .; Pokaż więcej
Źródło:: BMC veterinary research [BMC Vet Res] 2018 Dec 13; Vol. 14 (1), pp. 395. Date of Electronic Publication: 2018 Dec 13.
Typ publikacji:: Journal Article
MeSH Terms:: Enterovirus Infections/*enzymology
Host-Pathogen Interactions/*immunology
Mitogen-Activated Protein Kinases/*genetics
Mitogen-Activated Protein Kinases/*immunology
Signal Transduction/*immunology
Animals ; Cattle ; Cell Line ; Enterovirus/immunology ; Enterovirus Infections/genetics ; Enzyme Activation/immunology ; Gene Expression Profiling ; Phosphorylation

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Skocz do pozycji: 6.

Tytuł:: Maternal inheritance of twist and analysis of MAPK activation in embryos of the polychaete annelid Platynereis dumerilii.
Autorzy:: Pfeifer K; Institut für Allgemeine und Spezielle Zoologie; Allgemeine Zoologie und Entwicklungsbiologie, Justus-Liebig-Universität Gieβen, Gieβen, Germany.
Schaub C; Institut für Allgemeine und Spezielle Zoologie; Allgemeine Zoologie und Entwicklungsbiologie, Justus-Liebig-Universität Gieβen, Gieβen, Germany.
Domsch K; Institut für Allgemeine und Spezielle Zoologie; Allgemeine Zoologie und Entwicklungsbiologie, Justus-Liebig-Universität Gieβen, Gieβen, Germany.
Dorresteijn A; Institut für Allgemeine und Spezielle Zoologie; Allgemeine Zoologie und Entwicklungsbiologie, Justus-Liebig-Universität Gieβen, Gieβen, Germany.
Wolfstetter G; Institut für Allgemeine und Spezielle Zoologie; Allgemeine Zoologie und Entwicklungsbiologie, Justus-Liebig-Universität Gieβen, Gieβen, Germany.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2014 May 02; Vol. 9 (5), pp. e96702. Date of Electronic Publication: 2014 May 02 (Print Publication: 2014).
Typ publikacji:: Journal Article
MeSH Terms:: Enzyme Activation*
Gene Expression Regulation, Developmental*
Embryo, Nonmammalian/*embryology
Mitogen-Activated Protein Kinases/*metabolism
Polychaeta/*embryology
RNA, Messenger/*genetics
Twist-Related Protein 1/*genetics
Animals ; Embryo, Nonmammalian/metabolism ; Female ; Polychaeta/genetics ; RNA, Messenger/analysis

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Skocz do pozycji: 7.

Tytuł:: Activation of MAP kinases by green leaf volatiles in grasses.
Autorzy:: Dombrowski JE; USDA-ARS, National Forage Seed Production Research Center, 3450 SW Campus Way, Corvallis, OR, 97331-7102, USA. .
Martin RC; USDA-ARS, National Forage Seed Production Research Center, 3450 SW Campus Way, Corvallis, OR, 97331-7102, USA.; Pokaż więcej
Źródło:: BMC research notes [BMC Res Notes] 2018 Jan 29; Vol. 11 (1), pp. 79. Date of Electronic Publication: 2018 Jan 29.
Typ publikacji:: Journal Article
MeSH Terms:: Mitogen-Activated Protein Kinases/*metabolism
Plant Leaves/*metabolism
Poaceae/*metabolism
Volatile Organic Compounds/*metabolism
Electrophoresis, Polyacrylamide Gel ; Enzyme Activation ; Lolium/enzymology ; Solanum lycopersicum/enzymology ; Mitogen-Activated Protein Kinases/chemistry ; Molecular Weight ; Poaceae/classification ; Species Specificity ; Stress, Mechanical ; Time Factors

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Skocz do pozycji: 8.

Tytuł:: Synergistic Effect of Metal Oxide Nanoparticles on Cell Viability and Activation of MAP Kinases and NFκB.
Autorzy:: Dávila-Grana Á; Inmunología, Centro de Investigaciones Biomédicas (CINBIO), Centro Singular de Investigación de Galicia, Instituto de Investigación Sanitaria Galicia Sur (IIS-GS), Universidade de Vigo, Campus Universitario de Vigo, 36310 Pontevedra, Spain. .
Diego-González L; Inmunología, Centro de Investigaciones Biomédicas (CINBIO), Centro Singular de Investigación de Galicia, Instituto de Investigación Sanitaria Galicia Sur (IIS-GS), Universidade de Vigo, Campus Universitario de Vigo, 36310 Pontevedra, Spain. .
González-Fernández Á; Inmunología, Centro de Investigaciones Biomédicas (CINBIO), Centro Singular de Investigación de Galicia, Instituto de Investigación Sanitaria Galicia Sur (IIS-GS), Universidade de Vigo, Campus Universitario de Vigo, 36310 Pontevedra, Spain. .
Simón-Vázquez R; Inmunología, Centro de Investigaciones Biomédicas (CINBIO), Centro Singular de Investigación de Galicia, Instituto de Investigación Sanitaria Galicia Sur (IIS-GS), Universidade de Vigo, Campus Universitario de Vigo, 36310 Pontevedra, Spain. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2018 Jan 15; Vol. 19 (1). Date of Electronic Publication: 2018 Jan 15.
Typ publikacji:: Journal Article
MeSH Terms:: Metal Nanoparticles*/chemistry
Metals*/chemistry
Metals*/pharmacology
Oxides*/chemistry
Oxides*/pharmacology
Cell Survival/*drug effects
Mitogen-Activated Protein Kinases/*metabolism
NF-kappa B/*metabolism
Aluminum Oxide/chemistry ; Aluminum Oxide/pharmacology ; Drug Synergism ; Enzyme Activation/drug effects ; Humans ; Solubility ; Zinc Oxide/chemistry ; Zinc Oxide/pharmacology

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Skocz do pozycji: 9.

Tytuł:: 3-Hydroxy-4,7-megastigmadien-9-one, isolated from Ulva pertusa, attenuates TLR9-mediated inflammatory response by down-regulating mitogen-activated protein kinase and NF-κB pathways.
Autorzy:: Ali I; a School of Medicine and Brain Korea 21 PLUS Program , Jeju National University , Jeju , South Korea.; b Institute of Medical Science, Jeju National University , Jeju , South Korea.
Manzoor Z; a School of Medicine and Brain Korea 21 PLUS Program , Jeju National University , Jeju , South Korea.; b Institute of Medical Science, Jeju National University , Jeju , South Korea.
Koo JE; a School of Medicine and Brain Korea 21 PLUS Program , Jeju National University , Jeju , South Korea.; b Institute of Medical Science, Jeju National University , Jeju , South Korea.
Kim JE; c Department of Chemistry and Cosmetics, College of Natural Sciences , Jeju National University , Jeju , South Korea.
Byeon SH; c Department of Chemistry and Cosmetics, College of Natural Sciences , Jeju National University , Jeju , South Korea.
Yoo ES; a School of Medicine and Brain Korea 21 PLUS Program , Jeju National University , Jeju , South Korea.; b Institute of Medical Science, Jeju National University , Jeju , South Korea.
Kang HK; a School of Medicine and Brain Korea 21 PLUS Program , Jeju National University , Jeju , South Korea.; b Institute of Medical Science, Jeju National University , Jeju , South Korea.
Hyun JW; a School of Medicine and Brain Korea 21 PLUS Program , Jeju National University , Jeju , South Korea.; b Institute of Medical Science, Jeju National University , Jeju , South Korea.
Lee NH; c Department of Chemistry and Cosmetics, College of Natural Sciences , Jeju National University , Jeju , South Korea.
Koh YS; a School of Medicine and Brain Korea 21 PLUS Program , Jeju National University , Jeju , South Korea.; b Institute of Medical Science, Jeju National University , Jeju , South Korea.; Pokaż więcej
Źródło:: Pharmaceutical biology [Pharm Biol] 2017 Dec; Vol. 55 (1), pp. 435-440.
Typ publikacji:: Journal Article
MeSH Terms:: Anti-Inflammatory Agents/*pharmacology
Dendritic Cells/*drug effects
Mitogen-Activated Protein Kinases/*metabolism
NF-kappa B/*metabolism
Norisoprenoids/*pharmacology
Plant Extracts/*pharmacology
Signal Transduction/*drug effects
Toll-Like Receptor 9/*antagonists & inhibitors
Ulva/*chemistry
Animals ; Anti-Inflammatory Agents/isolation & purification ; CpG Islands ; Cytokines/metabolism ; Dendritic Cells/enzymology ; Dose-Response Relationship, Drug ; Enzyme Activation ; Female ; Genes, Reporter ; HEK293 Cells ; Humans ; Inflammation Mediators/metabolism ; Mice, Inbred C57BL ; NF-kappa B/genetics ; Norisoprenoids/isolation & purification ; Oligonucleotides/genetics ; Oligonucleotides/metabolism ; Phosphorylation ; Phytotherapy ; Plant Extracts/isolation & purification ; Plants, Medicinal ; Time Factors ; Toll-Like Receptor 9/genetics ; Toll-Like Receptor 9/metabolism ; Transcription Factor AP-1/genetics ; Transcription Factor AP-1/metabolism ; Transcription, Genetic/drug effects ; Transfection

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Skocz do pozycji: 10.

Tytuł:: Oxidative stress regulates mitogen‑activated protein kinases and c‑Jun activation involved in heat stress and lipopolysaccharide‑induced intestinal epithelial cell apoptosis.
Autorzy:: Liu Y; Department of Intensive Care Unit, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Wang Z; Graduate School, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, P.R. China.
Xie W; The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510000, P.R. China.
Gu Z; Department of Intensive Care Unit, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630; P.R. China.
Xu Q; Department of ICU, Key Laboratory of Tropical Zone Trauma Care and Tissue Repair of PLA, General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China.
Su L; Department of ICU, Key Laboratory of Tropical Zone Trauma Care and Tissue Repair of PLA, General Hospital of Guangzhou Military Command, Guangzhou, Guangdong 510010, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2017 Sep; Vol. 16 (3), pp. 2579-2587. Date of Electronic Publication: 2017 Jun 27.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*
Heat-Shock Response*
Oxidative Stress*
Intestinal Mucosa/*cytology
Lipopolysaccharides/*metabolism
Mitogen-Activated Protein Kinases/*metabolism
Caco-2 Cells ; Cell Line ; Enzyme Activation ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Intestinal Mucosa/metabolism ; JNK Mitogen-Activated Protein Kinases/metabolism ; Membrane Potential, Mitochondrial ; Permeability ; Reactive Oxygen Species/metabolism

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Skocz do pozycji: 11.

Tytuł:: Cudraflavone C Induces Apoptosis of A375.S2 Melanoma Cells through Mitochondrial ROS Production and MAPK Activation.
Autorzy:: Lee CW; Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chia-Yi 61363, Taiwan. .; Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chia-Yi 61363, Taiwan. .; Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan. .
Yen FL; Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. .; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan. .
Ko HH; Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. .
Li SY; Department of Pharmacy, College of Pharmacy & Health Care, Tajen University, Pingtung 90741, Taiwan. .
Chiang YC; Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chia-Yi 61363, Taiwan. .; Center for Drug Abuse and Addiction, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan. .
Lee MH; Division of Neurosurgery, Department of Surgery, Chang Gung Memorial Hospital, Chia-Yi61363, Taiwan. .
Tsai MH; Department of Pediatrics, Division of Neonatology and Pediatric Hematology/Oncology, Chang Gung Memorial Hospital, Yunlin 63862, Taiwan. .
Hsu LF; Department of Respiratory Care, Chang Gung University of Science and Technology, Chia-Yi Campus, Chia-Yi 61363, Taiwan. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2017 Jul 13; Vol. 18 (7). Date of Electronic Publication: 2017 Jul 13.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis/*drug effects
Flavones/*pharmacology
Melanoma/*enzymology
Melanoma/*pathology
Mitochondria/*metabolism
Mitogen-Activated Protein Kinases/*metabolism
Reactive Oxygen Species/*metabolism
Caspases/metabolism ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Enzyme Activation/drug effects ; Flavones/chemistry ; Humans ; Melanoma/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/drug effects ; Neoplasm Proteins/metabolism ; Phosphorylation/drug effects

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Skocz do pozycji: 12.

Tytuł:: Antiproliferation effect of guanosine on HCT 116 cells involves MAPK and AMPK pathways.
Autorzy:: Teoh WY; a Institute of Biological Sciences, Faculty of Science, University of Malaya , Kuala Lumpur , Malaysia.
Wahab NA; b Biology Division , Centre for Foundation Studies in Science, University of Malaya , Kuala Lumpur , Malaysia.
Sim KS; a Institute of Biological Sciences, Faculty of Science, University of Malaya , Kuala Lumpur , Malaysia.; Pokaż więcej
Źródło:: Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2017 Apr 03; Vol. 36 (4), pp. 243-255. Date of Electronic Publication: 2017 Mar 21.
Typ publikacji:: Journal Article
MeSH Terms:: AMP-Activated Protein Kinases/*metabolism
Antineoplastic Agents/*pharmacology
Guanosine/*pharmacology
Mitogen-Activated Protein Kinases/*metabolism
Cell Cycle Checkpoints/drug effects ; Cell Proliferation/drug effects ; Cyclin D1/metabolism ; Enzyme Activation/drug effects ; HCT116 Cells ; Humans ; MAP Kinase Signaling System/drug effects ; Mitogen-Activated Protein Kinases/pharmacokinetics ; Phosphorylation/drug effects

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Skocz do pozycji: 13.

Tytuł:: Nuclear relocation of Kss1 contributes to the specificity of the mating response.
Autorzy:: Pelet S; Department of Fundamental Microbiology University of Lausanne Lausanne, Switzerland.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2017 Mar 06; Vol. 7, pp. 43636. Date of Electronic Publication: 2017 Mar 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Nucleus/*metabolism
Fungal Proteins/*metabolism
Mitogen-Activated Protein Kinases/*metabolism
Alleles ; Cell Cycle Checkpoints ; Enzyme Activation ; Gene Expression Regulation, Fungal ; Mitogen-Activated Protein Kinases/genetics ; Models, Biological ; Protein Binding ; Protein Transport ; Signal Transduction

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Skocz do pozycji: 14.

Tytuł:: Oleanolic acid induces migration in Mv1Lu and MDA-MB-231 epithelial cells involving EGF receptor and MAP kinases activation.
Autorzy:: Bernabé-García Á; Laboratorio de Oncología Molecular y TGF-ß, Instituto Murciano de Investigaciones Biosanitarias-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain.
Armero-Barranco D; Departamento de Enfermería, Facultad Enfermería, Universidad de Murcia, Murcia, Spain.
Liarte S; Laboratorio de Oncología Molecular y TGF-ß, Instituto Murciano de Investigaciones Biosanitarias-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain.
Ruzafa-Martínez M; Departamento de Enfermería, Facultad Enfermería, Universidad de Murcia, Murcia, Spain.
Ramos-Morcillo AJ; Departamento de Enfermería, Facultad Enfermería, Universidad de Murcia, Murcia, Spain.
Nicolás FJ; Laboratorio de Oncología Molecular y TGF-ß, Instituto Murciano de Investigaciones Biosanitarias-Arrixaca, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2017 Feb 23; Vol. 12 (2), pp. e0172574. Date of Electronic Publication: 2017 Feb 23 (Print Publication: 2017).
Typ publikacji:: Journal Article
MeSH Terms:: Cell Movement/*drug effects
Enzyme Activators/*pharmacology
Epithelial Cells/*drug effects
ErbB Receptors/*metabolism
Mitogen-Activated Protein Kinases/*metabolism
Oleanolic Acid/*pharmacology
Cell Line ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Enzyme Activation/drug effects ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; ErbB Receptors/agonists ; Gene Expression Regulation/drug effects ; Humans ; MAP Kinase Kinase 4/metabolism ; MAP Kinase Signaling System/drug effects

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Skocz do pozycji: 15.

Tytuł:: Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes.
Autorzy:: Chae JK; College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon 21936, Korea. .
Subedi L; College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon 21936, Korea. .
Jeong M; College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon 21936, Korea. .
Park YU; College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon 21936, Korea. kong_.
Kim CY; College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan 15588, Korea. .
Kim H; Department of Applied Chemistry and Institute of Natural Sciences, Kyung Hee University, Global Campus, #1732 Deogyeong-daero, Giheung-gu, Yongin, Gyenggi-do 17104, Korea. .
Kim SY; College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon 21936, Korea. .; Gachon Medical Research Institute, Gil Medical Center, Inchon 21565, Korea. .; Gachon Institute of Pharmaceutical Science, Gachon University; #191 Hambakmoe-ro, Yeonsu-gu, Incheon 21565, Korea. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2017 Feb 22; Vol. 18 (2). Date of Electronic Publication: 2017 Feb 22.
Typ publikacji:: Journal Article
MeSH Terms:: Lignans/*pharmacology
Melanins/*biosynthesis
Melanocytes/*metabolism
Mitogen-Activated Protein Kinases/*metabolism
Phosphatidylinositol 3-Kinases/*metabolism
Polycyclic Compounds/*pharmacology
Proto-Oncogene Proteins c-akt/*metabolism
Signal Transduction/*drug effects
Animals ; Cell Line, Tumor ; Cell Survival/drug effects ; Cyclooctanes/pharmacology ; Enzyme Activation/drug effects ; Humans ; Melanocytes/drug effects ; Mice ; Monophenol Monooxygenase/metabolism ; Phosphorylation ; Receptor, Melanocortin, Type 1/metabolism ; Zebrafish

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Skocz do pozycji: 16.

Tytuł:: Expression of MMPs is dependent on the activity of mitogen-activated protein kinase in chondrosarcoma.
Autorzy:: Yao M; Department of Pathology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China.
Wang X; Department of Pathology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China.
Zhao Y; Department of Pathology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China.
Wang X; Department of Pathology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China.
Gao F; Department of Pathology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2017 Feb; Vol. 15 (2), pp. 915-921. Date of Electronic Publication: 2016 Dec 27.
Typ publikacji:: Journal Article
MeSH Terms:: Bone Neoplasms/*pathology
Chondrosarcoma/*pathology
Matrix Metalloproteinases/*analysis
Mitogen-Activated Protein Kinases/*analysis
Adult ; Aged ; Bone Neoplasms/metabolism ; Bone and Bones/metabolism ; Bone and Bones/pathology ; Cell Line, Tumor ; Chondrosarcoma/metabolism ; Collagen Type II/analysis ; Collagen Type II/metabolism ; Enzyme Activation ; Female ; Humans ; MAP Kinase Signaling System ; Male ; Matrix Metalloproteinases/metabolism ; Middle Aged ; Mitogen-Activated Protein Kinases/metabolism ; Tissue Inhibitor of Metalloproteinase-1/analysis ; Tissue Inhibitor of Metalloproteinase-1/metabolism

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Skocz do pozycji: 17.

Tytuł:: Inhibitory effect of a novel peptide, H-RN, on keratitis induced by LPS or poly(I:C) in vitro and in vivo via suppressing NF-κB and MAPK activation.
Autorzy:: Zhu S; Department of Ophthalmology, School of Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai, People's Republic of China.; Shanghai Key Laboratory of Fundus Disease, No. 100, Haining Road, Shanghai, People's Republic of China.
Xu X; Department of Ophthalmology, School of Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai, People's Republic of China.; Shanghai Key Laboratory of Fundus Disease, No. 100, Haining Road, Shanghai, People's Republic of China.
Wang L; Department of Ophthalmology, School of Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai, People's Republic of China.; Shanghai Key Laboratory of Fundus Disease, No. 100, Haining Road, Shanghai, People's Republic of China.
Su L; Department of Ophthalmology, School of Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai, People's Republic of China.; Shanghai Key Laboratory of Fundus Disease, No. 100, Haining Road, Shanghai, People's Republic of China.
Gu Q; Department of Ophthalmology, School of Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai, People's Republic of China.; Shanghai Key Laboratory of Fundus Disease, No. 100, Haining Road, Shanghai, People's Republic of China.
Wei F; Department of Ophthalmology, School of Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai, People's Republic of China.; Shanghai Key Laboratory of Fundus Disease, No. 100, Haining Road, Shanghai, People's Republic of China.
Liu K; Department of Ophthalmology, School of Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai, People's Republic of China. .; Shanghai Key Laboratory of Fundus Disease, No. 100, Haining Road, Shanghai, People's Republic of China. .; Pokaż więcej
Źródło:: Journal of translational medicine [J Transl Med] 2017 Jan 26; Vol. 15 (1), pp. 20. Date of Electronic Publication: 2017 Jan 26.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Hepatocyte Growth Factor/*therapeutic use
Keratitis/*drug therapy
Mitogen-Activated Protein Kinases/*metabolism
NF-kappa B/*metabolism
Peptide Fragments/*therapeutic use
Animals ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Cornea/pathology ; Cytokines/metabolism ; Enzyme Activation/drug effects ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Hepatocyte Growth Factor/pharmacology ; Humans ; Inflammation Mediators/metabolism ; Intercellular Adhesion Molecule-1/genetics ; Intercellular Adhesion Molecule-1/metabolism ; Keratitis/pathology ; Lipopolysaccharides ; MAP Kinase Signaling System/drug effects ; Male ; Peptide Fragments/pharmacology ; Phosphorylation/drug effects ; Poly I-C ; Protein Transport/drug effects ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Wistar

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Skocz do pozycji: 18.

Tytuł:: Sampling-based Bayesian approaches reveal the importance of quasi-bistable behavior in cellular decision processes on the example of the MAPK signaling pathway in PC-12 cell lines.
Autorzy:: Jensch A; Institute for Systems Theory and Automatic Control, University of Stuttgart, Pfaffenwaldring 9, Stuttgart, 70569, Germany.
Thomaseth C; Institute for Systems Theory and Automatic Control, University of Stuttgart, Pfaffenwaldring 9, Stuttgart, 70569, Germany.
Radde NE; Institute for Systems Theory and Automatic Control, University of Stuttgart, Pfaffenwaldring 9, Stuttgart, 70569, Germany. .; Pokaż więcej
Źródło:: BMC systems biology [BMC Syst Biol] 2017 Jan 25; Vol. 11 (1), pp. 11. Date of Electronic Publication: 2017 Jan 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: MAP Kinase Signaling System*/drug effects
Models, Biological*
Mitogen-Activated Protein Kinases/*metabolism
Animals ; Bayes Theorem ; Calibration ; Enzyme Activation/drug effects ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Feedback, Physiological/drug effects ; Nerve Growth Factor/pharmacology ; PC12 Cells ; Protein Kinase C/metabolism ; Rats

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Skocz do pozycji: 19.

Tytuł:: Neurotrophin Promotes Neurite Outgrowth by Inhibiting Rif GTPase Activation Downstream of MAPKs and PI3K Signaling.
Autorzy:: Tian X; School of Life Sciences, Inner Mongolia University, Hohhot 010021, China. .
Yan H; School of Life Sciences, Inner Mongolia University, Hohhot 010021, China. .
Li J; School of Life Sciences, Inner Mongolia University, Hohhot 010021, China. .
Wu S; School of Life Sciences, Inner Mongolia University, Hohhot 010021, China. .
Wang J; School of Life Sciences, Inner Mongolia University, Hohhot 010021, China. .
Fan L; School of Life Sciences, Inner Mongolia University, Hohhot 010021, China. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2017 Jan 13; Vol. 18 (1). Date of Electronic Publication: 2017 Jan 13.
Typ publikacji:: Journal Article
MeSH Terms:: GTP Phosphohydrolases/*antagonists & inhibitors
Mitogen-Activated Protein Kinases/*metabolism
Nerve Growth Factor/*pharmacology
Neurites/*metabolism
Phosphatidylinositol 3-Kinases/*metabolism
Signal Transduction/*drug effects
Animals ; Cytoskeletal Proteins/metabolism ; Enzyme Activation/drug effects ; GTP Phosphohydrolases/metabolism ; Humans ; Mitogens/pharmacology ; Models, Biological ; Nerve Tissue Proteins/metabolism ; Neurites/drug effects ; PC12 Cells ; Rats ; Receptors, Cell Surface/metabolism ; Semaphorins/pharmacology

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Skocz do pozycji: 20.

Tytuł:: The suppression of bromodomain and extra-terminal domain inhibits vascular inflammation by blocking NF-κB and MAPK activation.
Autorzy:: Huang M; Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Zeng S; Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Zou Y; Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Shi M; Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Qiu Q; Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Xiao Y; Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Chen G; Department of Rheumatology, The First People's Hospital of Foshan, Foshan, Guangdong, China.
Yang X; Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Liang L; Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Xu H; Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2017 Jan; Vol. 174 (1), pp. 101-115. Date of Electronic Publication: 2016 Nov 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Azepines/*pharmacology
Inflammation/*drug therapy
Mitogen-Activated Protein Kinases/*metabolism
NF-kappa B/*metabolism
Protein Kinase Inhibitors/*pharmacology
Transcription Factors/*antagonists & inhibitors
Transcription Factors/*metabolism
Triazoles/*pharmacology
Cells, Cultured ; Dose-Response Relationship, Drug ; Enzyme Activation/drug effects ; Humans ; Inflammation/metabolism ; Structure-Activity Relationship

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