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Tytuł :
Morphine-induced kinase activation and localization in the periaqueductal gray of male and female mice.
Autorzy :
Ram A; Department of Biology, Utah State University, Logan, Utah, USA.
Edwards TM; Department of Biology, Utah State University, Logan, Utah, USA.
McCarty A; Department of Biology, Utah State University, Logan, Utah, USA.
McDermott MV; Department of Biology, Utah State University, Logan, Utah, USA.; Interdisciplinary Neuroscience Program, Utah State University, Logan, Utah, USA.
Bobeck EN; Department of Biology, Utah State University, Logan, Utah, USA.; Interdisciplinary Neuroscience Program, Utah State University, Logan, Utah, USA.
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Źródło :
Journal of neurochemistry [J Neurochem] 2021 Nov; Vol. 159 (3), pp. 590-602. Date of Electronic Publication: 2021 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enzyme Induction/*drug effects
Morphine/*pharmacology
Periaqueductal Gray/*drug effects
Periaqueductal Gray/*enzymology
Protein Kinases/*biosynthesis
Animals ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Drug Tolerance ; Female ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Pain Measurement/drug effects ; Protein Kinase C/metabolism ; Protein Transport ; Sex Characteristics ; Vesicular Transport Proteins/biosynthesis ; Vesicular Transport Proteins/genetics
Czasopismo naukowe
Tytuł :
Hepatic ADTRP overexpression does not influence lipid and glucose metabolism.
Autorzy :
Defour M; Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
van Weeghel M; Laboratory Genetic Metabolic Diseases, Amsterdam UMC, Amsterdam, The Netherlands.; Core Facility Metabolomics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Hermans J; Laboratory Genetic Metabolic Diseases, Amsterdam UMC, Amsterdam, The Netherlands.; Core Facility Metabolomics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Kersten S; Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2021 Oct 01; Vol. 321 (4), pp. C585-C595. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lipid Metabolism*
Esterases/*biosynthesis
Glucose/*metabolism
Hepatocytes/*enzymology
Lipids/*blood
Membrane Proteins/*biosynthesis
3T3-L1 Cells ; Adipocytes/enzymology ; Animals ; Disease Models, Animal ; Enzyme Induction ; Esterases/genetics ; Fasting/metabolism ; Female ; Lipidomics ; Male ; Membrane Proteins/genetics ; Mice ; Mice, 129 Strain ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Mice, Knockout ; Obesity/enzymology ; Obesity/genetics ; PPAR alpha/genetics ; PPAR alpha/metabolism ; PPAR gamma/metabolism
Czasopismo naukowe
Tytuł :
Nicotine stimulates CYP1A1 expression in human hepatocellular carcinoma cells via AP-1, NF-κB, and AhR.
Autorzy :
Ung TT; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 61469, Republic of Korea; Nanogen Biopharmaceutical Company, Lot I - 5C Saigon Hitech Park, Tang Nhon Phu A Ward, District 9, Ho Chi Minh City, Viet Nam.
Nguyen TT; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 61469, Republic of Korea; Nanogen Biopharmaceutical Company, Lot I - 5C Saigon Hitech Park, Tang Nhon Phu A Ward, District 9, Ho Chi Minh City, Viet Nam.
Li S; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.
Han JY; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 61469, Republic of Korea; Department of Physical and Rehabilitation Medicine, Chonnam National University Medical School and Hospital, Gwangju, 61469, Republic of Korea.
Jung YD; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 61469, Republic of Korea. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Oct 01; Vol. 349, pp. 155-164. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Carcinoma, Hepatocellular/*enzymology
Cytochrome P-450 CYP1A1/*biosynthesis
Liver Neoplasms/*enzymology
Nicotine/*toxicity
Nicotinic Agonists/*toxicity
Receptors, Aryl Hydrocarbon/*metabolism
Transcription Factor AP-1/*metabolism
Basic Helix-Loop-Helix Transcription Factors/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation/drug effects ; Cytochrome P-450 CYP1A1/genetics ; Enzyme Induction ; Hep G2 Cells ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Aryl Hydrocarbon/genetics ; Signal Transduction ; Transcription Factor AP-1/genetics ; Transcription Factor RelA/genetics ; Transcription Factor RelA/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Exploring the Use of Serum-Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Hepatic Cytochromes P450 and Organic Anion Transporting Polypeptides.
Autorzy :
Rodrigues AD; ADME Sciences, Medicine Design, Worldwide Research & Development, Pfizer Inc., Groton, Connecticut, USA.
van Dyk M; College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Sorich MJ; College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Fahmy A; College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Useckaite Z; College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Newman LA; College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Kapetas AJ; College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Mounzer R; College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Wood LS; Pharmacogenomics, Precision Medicine, Worldwide Research & Development, Pfizer Inc., Groton, Connecticut, USA.
Johnson JG; Pharmacogenomics, Precision Medicine, Worldwide Research & Development, Pfizer Inc., Groton, Connecticut, USA.
Rowland A; College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
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Źródło :
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 Jul; Vol. 110 (1), pp. 248-258. Date of Electronic Publication: 2021 Apr 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytochrome P-450 Enzyme System/*metabolism
Extracellular Vesicles/*metabolism
Liver/*metabolism
Organic Anion Transporters/*metabolism
Adult ; Area Under Curve ; Cytochrome P-450 Enzyme System/genetics ; Dextromethorphan/pharmacokinetics ; Enzyme Induction/drug effects ; Enzyme Induction/genetics ; Female ; Genotype ; Humans ; Liquid Biopsy ; Liver/enzymology ; Male ; Midazolam/pharmacokinetics ; Pregnancy ; Proteomics ; Rifampin/pharmacology ; Young Adult
Czasopismo naukowe
Tytuł :
Effect of Continuous Feeding of Ayu-Narezushi on Lipid Metabolism in a Mouse Model of Metabolic Syndrome.
Autorzy :
Nishida T; Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Tsuneyama K; Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.
Tago Y; Fisheries Research Institute, Toyama Prefectural Agricultural, Forestry & Fisheries Research Center, 364 Takatsuka, Namerikawa 936-8536, Japan.
Nomura K; Fisheries Research Institute, Toyama Prefectural Agricultural, Forestry & Fisheries Research Center, 364 Takatsuka, Namerikawa 936-8536, Japan.
Fujimoto M; Department of Japanese Oriental Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Nakajima T; Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Noguchi A; Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Minamisaka T; Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Hatta H; Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Imura J; Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
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Źródło :
TheScientificWorldJournal [ScientificWorldJournal] 2021 Sep 06; Vol. 2021, pp. 1583154. Date of Electronic Publication: 2021 Sep 06 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Fermented Foods and Beverages*
Lipid Metabolism*
Osmeriformes*
Metabolic Syndrome/*diet therapy
Acyl-CoA Oxidase/biosynthesis ; Acyl-CoA Oxidase/genetics ; Animals ; Body Weight ; Carnitine O-Palmitoyltransferase/biosynthesis ; Carnitine O-Palmitoyltransferase/genetics ; Cholesterol/blood ; Dyslipidemias/diet therapy ; Dyslipidemias/genetics ; Enzyme Induction ; Fatty Acids/metabolism ; Gene Expression Regulation ; Intra-Abdominal Fat/chemistry ; Intra-Abdominal Fat/pathology ; Japan ; Liver/metabolism ; Metabolic Syndrome/blood ; Metabolic Syndrome/genetics ; Mice ; Mice, Obese ; Obesity/diet therapy ; Obesity/genetics ; Oryza ; Oxidation-Reduction ; PPAR alpha/biosynthesis ; PPAR alpha/genetics ; Real-Time Polymerase Chain Reaction ; Sodium Chloride ; Triglycerides/blood
Czasopismo naukowe
Tytuł :
A Dual Target-Directed Single Domain-Based Fusion Protein Against Interleukin-6 Receptor Decelerate Experimental Arthritis Progression Via Modulating JNK Expression.
Autorzy :
Chen X; Department of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.; Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, Fujian Medical University, Fuzhou, Fujian, China.
Bian Y; Department of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Xie Y; Department of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Zheng N; Department of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Nie K; Department of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Liu R; Department of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Yan M; Department of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Luo H; Department of Orthopedics,The First Affiliated Hospital of Fujian Medical University, Fujian, Fuzhou, China.
Wang H; School of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. .
Yang J; Department of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China. .; Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, Fujian Medical University, Fuzhou, Fujian, China. .
Zhang N; Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, Fujian Medical University, Fuzhou, Fujian, China. .; Department of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China. .
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Źródło :
Inflammation [Inflammation] 2021 Aug; Vol. 44 (4), pp. 1620-1628. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*immunology
Arthritis, Experimental/*drug therapy
Interleukin-6/*antagonists & inhibitors
Serum Albumin, Human/*antagonists & inhibitors
Single-Domain Antibodies/*immunology
Animals ; Anti-Inflammatory Agents/therapeutic use ; Antibody Specificity ; Arthritis, Experimental/immunology ; Cytokines/metabolism ; DNA, Complementary/genetics ; Dexamethasone/therapeutic use ; Drug Evaluation, Preclinical ; Enzyme Induction/drug effects ; Humans ; Interleukin-6/immunology ; Lipopolysaccharides/toxicity ; MAP Kinase Kinase 4/biosynthesis ; MAP Kinase Kinase 4/genetics ; Mice ; Models, Molecular ; Molecular Targeted Therapy ; Nitric Oxide/metabolism ; Protein Conformation ; RAW 264.7 Cells ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/immunology ; Serum Albumin, Human/immunology ; Single-Domain Antibodies/genetics
Czasopismo naukowe
Tytuł :
Constitutive activation of NF-κB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma.
Autorzy :
Davis JL; Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, United States of America.; Department of Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, United States of America.
Thaler R; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, United States of America.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States of America.
Cox L; Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, United States of America.; Department of Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, United States of America.
Ricci B; Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, United States of America.; Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, MO, United States of America.
Zannit HM; Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, United States of America.; Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, MO, United States of America.
Wan F; Department of Surgery, Division of Public Health Sciences, Washington University School of Medicine, St. Louis, MO, United States of America.
Faccio R; Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, United States of America.; Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, MO, United States of America.; Shriners Hospitals for Children-St. Louis, St. Louis, MO, United States of America.
Dudakovic A; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, United States of America.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States of America.
van Wijnen AJ; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, United States of America.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States of America.
Veis DJ; Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, United States of America.; Department of Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, United States of America.; Shriners Hospitals for Children-St. Louis, St. Louis, MO, United States of America.
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Źródło :
PloS one [PLoS One] 2021 Jul 22; Vol. 16 (7), pp. e0254426. Date of Electronic Publication: 2021 Jul 22 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Integrases*/genetics
Integrases*/metabolism
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
Protein-Serine-Threonine Kinases*/biosynthesis
Protein-Serine-Threonine Kinases*/genetics
S100 Calcium-Binding Protein A4*/genetics
S100 Calcium-Binding Protein A4*/metabolism
Sarcoma, Experimental*/genetics
Sarcoma, Experimental*/metabolism
Sarcoma, Experimental*/pathology
Sp7 Transcription Factor*/genetics
Sp7 Transcription Factor*/metabolism
Animals ; Enzyme Induction ; Mice ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Heterologous Expression and Auto-Activation of Human Pro-Inflammatory Caspase-1 in Saccharomyces cerevisiae and Comparison to Caspase-8.
Autorzy :
Valenti M; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Universidad Complutense de Madrid, Madrid, Spain.
Molina M; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Universidad Complutense de Madrid, Madrid, Spain.
Cid VJ; Departamento de Microbiología y Parasitología, Facultad de Farmacia, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Universidad Complutense de Madrid, Madrid, Spain.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Jul 14; Vol. 12, pp. 668602. Date of Electronic Publication: 2021 Jul 14 (Print Publication: 2021).
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Caspase 1/*biosynthesis
Caspase 8/*biosynthesis
Mitochondria/*enzymology
Saccharomyces cerevisiae/*enzymology
Actin Cytoskeleton/enzymology ; Actin Cytoskeleton/genetics ; Caspase 1/genetics ; Caspase 8/genetics ; Enzyme Activation ; Enzyme Induction ; Galactokinase/genetics ; Galactokinase/metabolism ; Gene Expression Regulation, Fungal ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Microbial Viability ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Mitochondria/genetics ; Phosphate-Binding Proteins/genetics ; Phosphate-Binding Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/growth & development ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Fludarabine inhibits type I interferon-induced expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2.
Autorzy :
Xiu H; Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Gong J; Institute of Immunology, and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Huang T; Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Peng Y; Institute of Immunology, and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Bai S; Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiong G; Department of Emergency Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Zhang S; Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Huang H; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. .
Cai Z; Institute of Immunology, and Department of Orthopaedics of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. .
Zhang G; Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. .
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Źródło :
Cellular & molecular immunology [Cell Mol Immunol] 2021 Jul; Vol. 18 (7), pp. 1829-1831. Date of Electronic Publication: 2021 May 31.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiotensin-Converting Enzyme 2/*biosynthesis
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Interferon Type I/*pharmacology
Receptors, Virus/*biosynthesis
STAT1 Transcription Factor/*antagonists & inhibitors
Vidarabine/*analogs & derivatives
A549 Cells ; Angiotensin-Converting Enzyme 2/genetics ; Binding Sites ; COVID-19/enzymology ; COVID-19/virology ; Enzyme Induction ; HEK293 Cells ; HeLa Cells ; Humans ; Phosphorylation ; Promoter Regions, Genetic ; Receptors, Virus/genetics ; STAT1 Transcription Factor/metabolism ; Vidarabine/pharmacology
SCR Protocol :
COVID-19 drug treatment
Raport
Tytuł :
A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction.
Autorzy :
Li H; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Wang YG; Institute of Radiation Medicine Academy of Military Medical Sciences, Beijing, China.
Ma ZC; Institute of Radiation Medicine Academy of Military Medical Sciences, Beijing, China.
Yun-Hang G; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Ling S; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Teng-Fei C; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Guang-Ping Z; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Gao Y; Institute of Radiation Medicine Academy of Military Medical Sciences, Beijing, China.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Jul; Vol. 51 (7), pp. 752-763. Date of Electronic Publication: 2021 May 03.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 CYP3A*/metabolism
Receptors, Steroid*/genetics
Receptors, Steroid*/metabolism
Cytochrome P-450 CYP1A1 ; Cytochrome P-450 CYP2B6/genetics ; Cytochrome P-450 CYP2B6/metabolism ; Enzyme Induction ; Genes, Reporter ; Hepatocytes/metabolism ; Luciferases/genetics
Czasopismo naukowe
Tytuł :
Epilepsy, antiepileptic drugs, and the risk of major cardiovascular events.
Autorzy :
Lee-Lane E; Swansea University Medical School, Swansea University, Swansea, UK.
Torabi F; Swansea University Medical School, Swansea University, Swansea, UK.
Lacey A; Swansea University Medical School, Swansea University, Swansea, UK.
Fonferko-Shadrach B; Swansea University Medical School, Swansea University, Swansea, UK.
Harris D; Swansea University Medical School, Swansea University, Swansea, UK.; Swansea Bay University Health Board, Swansea, UK.
Akbari A; Swansea University Medical School, Swansea University, Swansea, UK.
Lyons RA; Swansea University Medical School, Swansea University, Swansea, UK.
Rees MI; Swansea University Medical School, Swansea University, Swansea, UK.; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Sawhney I; Swansea University Medical School, Swansea University, Swansea, UK.; Swansea Bay University Health Board, Swansea, UK.
Halcox J; Swansea University Medical School, Swansea University, Swansea, UK.; Swansea Bay University Health Board, Swansea, UK.
Powell R; Swansea University Medical School, Swansea University, Swansea, UK.; Swansea Bay University Health Board, Swansea, UK.
Pickrell WO; Swansea University Medical School, Swansea University, Swansea, UK.; Swansea Bay University Health Board, Swansea, UK.
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Źródło :
Epilepsia [Epilepsia] 2021 Jul; Vol. 62 (7), pp. 1604-1616. Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anticonvulsants/*adverse effects
Anticonvulsants/*therapeutic use
Cardiovascular Diseases/*etiology
Epilepsy/*complications
Epilepsy/*drug therapy
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cardiovascular Diseases/epidemiology ; Case-Control Studies ; Cohort Studies ; Enzyme Induction/drug effects ; Epilepsy/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Survival Analysis ; Treatment Outcome ; United Kingdom/epidemiology ; Wales ; Young Adult
Czasopismo naukowe
Tytuł :
Exogenous Vitamins K Exert Anti-Inflammatory Effects Dissociated from Their Role as Substrates for Synthesis of Endogenous MK-4 in Murine Macrophages Cell Line.
Autorzy :
Kieronska-Rudek A; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzynskiego 14, 30-348 Krakow, Poland.; Department of Pharmacology, Medical College, Jagiellonian University, Grzegorzecka 16, 31-531 Krakow, Poland.
Kij A; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzynskiego 14, 30-348 Krakow, Poland.
Kaczara P; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzynskiego 14, 30-348 Krakow, Poland.
Tworzydlo A; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzynskiego 14, 30-348 Krakow, Poland.
Napiorkowski M; Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793 Warszawa, Poland.
Sidoryk K; Chemistry Department, Pharmaceutical Research Institute, Rydygiera 8, 01-793 Warszawa, Poland.
Chlopicki S; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzynskiego 14, 30-348 Krakow, Poland.; Department of Pharmacology, Medical College, Jagiellonian University, Grzegorzecka 16, 31-531 Krakow, Poland.
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Źródło :
Cells [Cells] 2021 Jun 22; Vol. 10 (7). Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Macrophages/*metabolism
Vitamin K/*pharmacology
Animals ; Atorvastatin/pharmacology ; Cell Respiration/drug effects ; Cyclooxygenase 2/biosynthesis ; Cytokines/biosynthesis ; Eicosanoids/biosynthesis ; Enzyme Induction/drug effects ; Lipopolysaccharides/pharmacology ; Macrophages/drug effects ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/metabolism ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Nitric Oxide/biosynthesis ; Nitric Oxide Synthase Type II/metabolism ; RAW 264.7 Cells ; Substrate Specificity/drug effects
Czasopismo naukowe
Tytuł :
Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2.
Autorzy :
Bachmann F; Division of Clinical Pharmacology & Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, Basel, Switzerland.
Duthaler U; Division of Clinical Pharmacology & Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, Basel, Switzerland.
Meyer Zu Schwabedissen HE; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Puchkov M; Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Huwyler J; Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Haschke M; Clinical Pharmacology and Toxicology, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Institute of Pharmacology, University of Bern, Bern, Switzerland.
Krähenbühl S; Division of Clinical Pharmacology & Toxicology, University Hospital Basel, Basel, Switzerland.; Department of Biomedicine, University of Basel, Basel, Switzerland.
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Źródło :
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 Jun; Vol. 109 (6), pp. 1505-1516. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Cytochrome P-450 CYP1A2/*genetics
Cytochrome P-450 CYP1A2 Inhibitors/*pharmacology
Cytochrome P-450 Enzyme Inducers/*pharmacology
Cytochrome P-450 Enzyme System/*biosynthesis
Dipyrone/*pharmacology
Enzyme Induction/*drug effects
Adult ; Area Under Curve ; Cell Line ; Cytochrome P-450 CYP2B6/biosynthesis ; Cytochrome P-450 CYP2B6/genetics ; Cytochrome P-450 CYP2C9/biosynthesis ; Cytochrome P-450 CYP2C9/genetics ; Cytochrome P-450 Enzyme System/genetics ; Drug Interactions ; Female ; Genotype ; Healthy Volunteers ; Humans ; Male ; Pregnane X Receptor/antagonists & inhibitors ; Pregnane X Receptor/genetics ; Receptors, Cytoplasmic and Nuclear/antagonists & inhibitors ; Receptors, Cytoplasmic and Nuclear/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
Reduction of Superoxide Dismutase 1 Delays Regeneration of Cardiotoxin-Injured Skeletal Muscle in KK/Ta- Ins2 Mice with Progressive Diabetic Nephropathy.
Autorzy :
Takahashi Y; Department of Metabolism and Endocrinology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
Shimizu T; Department of Metabolism and Endocrinology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
Kato S; Department of Metabolism and Endocrinology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
Nara M; Department of Metabolism and Endocrinology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
Suganuma Y; Department of Metabolism and Endocrinology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
Sato T; Department of Metabolism and Endocrinology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
Morii T; Department of Metabolism and Endocrinology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
Yamada Y; Department of Metabolism and Endocrinology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.; Kansai Electric Power Medical Research Institute, 2-1-7 Fukushima-ku, Osaka 553-0003, Japan.
Fujita H; Department of Metabolism and Endocrinology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 23; Vol. 22 (11). Date of Electronic Publication: 2021 May 23.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetic Nephropathies/*complications
Muscle, Skeletal/*drug effects
Nerve Regeneration/*drug effects
Sarcopenia/*etiology
Superoxide Dismutase-1/*drug effects
Animals ; Cardiotoxins/toxicity ; Collagen Type I/biosynthesis ; Collagen Type I/genetics ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/genetics ; Diabetic Nephropathies/enzymology ; Diabetic Nephropathies/genetics ; Diabetic Nephropathies/pathology ; Disease Progression ; Enzyme Induction/drug effects ; Fibrosis ; Gene Expression Regulation, Enzymologic ; Genetic Predisposition to Disease ; Glomerular Mesangium/pathology ; Inflammation ; Insulin/deficiency ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Muscle, Skeletal/enzymology ; Muscle, Skeletal/pathology ; Muscle, Skeletal/physiology ; Oxidative Stress/drug effects ; Superoxide Dismutase-1/biosynthesis ; Superoxide Dismutase-1/genetics ; Superoxide Dismutase-1/physiology ; Superoxides/metabolism
Czasopismo naukowe
Tytuł :
PARK7 Protects Against Chronic Kidney Injury and Renal Fibrosis by Inducing SOD2 to Reduce Oxidative Stress.
Autorzy :
Yin L; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital at Central South University, Changsha, China.
Li H; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital at Central South University, Changsha, China.
Liu Z; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital at Central South University, Changsha, China.
Wu W; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital at Central South University, Changsha, China.
Cai J; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital at Central South University, Changsha, China.
Tang C; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital at Central South University, Changsha, China.
Dong Z; Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital at Central South University, Changsha, China.; Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center, Augusta, GA, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 May 21; Vol. 12, pp. 690697. Date of Electronic Publication: 2021 May 21 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Oxidative Stress*
Kidney Diseases/*prevention & control
Kidney Tubules, Proximal/*enzymology
Protein Deglycase DJ-1/*metabolism
Reactive Oxygen Species/*metabolism
Superoxide Dismutase/*biosynthesis
Animals ; Apoptosis ; Cell Line ; Disease Models, Animal ; Enzyme Induction ; Fibrosis ; Kidney Diseases/enzymology ; Kidney Diseases/etiology ; Kidney Diseases/pathology ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Protein Deglycase DJ-1/genetics ; Signal Transduction ; Superoxide Dismutase/genetics ; Transforming Growth Factor beta1/pharmacology ; Ureteral Obstruction/complications
Czasopismo naukowe
Tytuł :
Therapeutic monitoring of carbamazepine and its active metabolite during the 1st postnatal month: Influence of drug interactions.
Autorzy :
Kacirova I; Department of Clinical Pharmacology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava, Czech Republic; Department of Clinical Pharmacology, Department of Laboratory Medicine, University Hospital Ostrava, 17. listopadu 1790, 700 30 Ostrava, Czech Republic.
Grundmann M; Department of Clinical Pharmacology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava, Czech Republic. Electronic address: .
Brozmanova H; Department of Clinical Pharmacology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava, Czech Republic; Department of Clinical Pharmacology, Department of Laboratory Medicine, University Hospital Ostrava, 17. listopadu 1790, 700 30 Ostrava, Czech Republic.
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 May; Vol. 137, pp. 111412. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
Anticonvulsants/*pharmacokinetics
Carbamazepine/*pharmacokinetics
Adult ; Anticonvulsants/metabolism ; Biotransformation ; Breast Feeding ; Carbamazepine/metabolism ; Cohort Studies ; Drug Interactions ; Drug Monitoring ; Enzyme Induction/drug effects ; Epoxy Compounds/metabolism ; Female ; Humans ; Infant, Newborn ; Male ; Milk, Human/chemistry ; Milk, Human/metabolism ; Valproic Acid/pharmacokinetics ; Young Adult
Czasopismo naukowe
Tytuł :
Induction of Cyp450 enzymes by 4-thiazolidinone-based derivatives in 3T3-L1 cells in vitro.
Autorzy :
Szychowski KA; Department of Lifestyle Disorders and Regenerative Medicine, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225, Rzeszow, Poland. .
Skóra B; Department of Lifestyle Disorders and Regenerative Medicine, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225, Rzeszow, Poland.
Kryshchyshyn-Dylevych A; Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, Lviv, 79010, Ukraine.
Kaminskyy D; Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, Lviv, 79010, Ukraine.
Rybczyńska-Tkaczyk K; Department of Environmental Microbiology, University of Life Sciences, Leszczyńskiego 7, 20-069, Lublin, Poland.
Lesyk R; Department of Lifestyle Disorders and Regenerative Medicine, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225, Rzeszow, Poland.; Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, Lviv, 79010, Ukraine.
Gmiński J; Department of Lifestyle Disorders and Regenerative Medicine, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225, Rzeszow, Poland.
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Źródło :
Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2021 May; Vol. 394 (5), pp. 915-927. Date of Electronic Publication: 2020 Nov 21.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Cytochrome P-450 Enzyme System/*biosynthesis
Enzyme Induction/*drug effects
Thiazolidines/*pharmacology
3T3-L1 Cells ; Animals ; Mice ; RNA, Messenger/metabolism ; Thiazolidines/chemical synthesis
Czasopismo naukowe
Tytuł :
Glucagon-like peptide 1 analogue prevents cholesterol gallstone formation by modulating intestinal farnesoid X receptor activity.
Autorzy :
Zhang Z; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China; Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.
Du Z; Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China.
Liu Q; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.
Wu T; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China; Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.
Tang Q; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China; Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.
Zhang J; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China; Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.
Huang C; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China; Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.
Huang Y; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China; Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.
Li R; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China; Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.
Li Y; Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.
Zhao Y; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China; Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.
Zhang G; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China; Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.
Zhou J; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China; Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.
Huang H; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China; Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China.
Fang Z; Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China. Electronic address: .
He J; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China; Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, China. Electronic address: .
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Źródło :
Metabolism: clinical and experimental [Metabolism] 2021 May; Vol. 118, pp. 154728. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cholesterol/*metabolism
Gallstones/*prevention & control
Intestinal Mucosa/*metabolism
Liraglutide/*pharmacology
Receptors, Cytoplasmic and Nuclear/*metabolism
Animals ; Bile Acids and Salts/biosynthesis ; Cholesterol 7-alpha-Hydroxylase/biosynthesis ; Cholesterol 7-alpha-Hydroxylase/metabolism ; Diet ; Enzyme Induction ; Fibroblast Growth Factors/metabolism ; Gallstones/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Microsomes, Liver/enzymology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters.
Autorzy :
Ciscato F; Dipartimento di Scienze Biomediche, Università di Padova, 35131 Padova, Italy.
Ferrone L; Dipartimento di Scienze Biomediche, Università di Padova, 35131 Padova, Italy.
Masgras I; Dipartimento di Scienze Biomediche, Università di Padova, 35131 Padova, Italy.; Institute of Neuroscience, National Research Council, 56124 Pias, Italy.
Laquatra C; Dipartimento di Scienze Biomediche, Università di Padova, 35131 Padova, Italy.
Rasola A; Dipartimento di Scienze Biomediche, Università di Padova, 35131 Padova, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 29; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Hexokinase/*physiology
Neoplasm Proteins/*physiology
Neoplasms/*enzymology
Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/physiology ; Autophagy/physiology ; Calcium Signaling/physiology ; Cell Hypoxia ; Cell-Penetrating Peptides/therapeutic use ; Enzyme Induction ; Gene Expression Regulation, Neoplastic ; Glycolysis/physiology ; Hexokinase/antagonists & inhibitors ; Humans ; Intracellular Membranes/enzymology ; Mice ; MicroRNAs/genetics ; Mitochondria/metabolism ; Molecular Targeted Therapy ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasms/therapy ; Neoplasms, Experimental/enzymology ; Phosphorylation ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Protein Processing, Post-Translational ; Rats ; Ubiquitination
Czasopismo naukowe
Tytuł :
Cytokine-mediated induction of human xylosyltransferase-I in systemic sclerosis skin fibroblasts.
Autorzy :
Ly TD; Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Georgstraße 11, 32545, Bad Oeynhausen, Germany.
Kleine A; Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Georgstraße 11, 32545, Bad Oeynhausen, Germany.
Plümers R; Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Georgstraße 11, 32545, Bad Oeynhausen, Germany.
Fischer B; Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Georgstraße 11, 32545, Bad Oeynhausen, Germany.
Schmidt V; Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Georgstraße 11, 32545, Bad Oeynhausen, Germany.
Hendig D; Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Georgstraße 11, 32545, Bad Oeynhausen, Germany.
Distler JHW; Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, 91054, Erlangen, Germany.
Kuhn J; Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Georgstraße 11, 32545, Bad Oeynhausen, Germany.
Knabbe C; Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Georgstraße 11, 32545, Bad Oeynhausen, Germany.
Faust I; Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Georgstraße 11, 32545, Bad Oeynhausen, Germany. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Apr 16; Vol. 549, pp. 34-39. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytokines/*pharmacology
Fibroblasts/*enzymology
Fibroblasts/*pathology
Pentosyltransferases/*biosynthesis
Scleroderma, Systemic/*enzymology
Skin/*pathology
Enzyme Induction/drug effects ; Fibroblasts/drug effects ; Humans ; Interleukin-1beta/pharmacology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Pentosyltransferases/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptor, Transforming Growth Factor-beta Type II/genetics ; Receptor, Transforming Growth Factor-beta Type II/metabolism ; Scleroderma, Systemic/genetics ; Scleroderma, Systemic/pathology ; Transforming Growth Factor beta1/pharmacology
Czasopismo naukowe

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