Temat: "Enzyme Inhibitors" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: Risk Factors for Angiotension-Converting Enzyme Inhibitor-Associated Cough.
Autorzy :: Cimolai N; Faculty of Medicine, The University of British Columbia and Children's and Women's Health Centre of British Columbia, Vancouver, British Columbia, Canada.; Pokaż więcej
Źródło :: Journal of clinical pharmacology [J Clin Pharmacol] 2021 Sep; Vol. 61 (9), pp. 1251-1252. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji :: Letter; Comment
MeSH Terms :: Angiotensin-Converting Enzyme Inhibitors*
Cough*/chemically induced
Cough*/drug therapy
Enzyme Inhibitors ; Humans ; Risk Factors
: Opinia redakcyjna

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: Recent advances in the synthesis of 4'-truncated nucleoside phosphonic acid analogues.
Autorzy :: Shen GH; Postdoctoral Programme of Meteria Medica Institute of Harbin University of Commerce, Harbin, 150076, PR China.
Hong JH; College of Pharmacy, Chosun University, Kwangju, 501-759, Republic of Korea. Electronic address: .; Pokaż więcej
Źródło :: Carbohydrate research [Carbohydr Res] 2022 Mar; Vol. 513, pp. 108517. Date of Electronic Publication: 2022 Feb 07.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Antiviral Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Enzymes/*metabolism
Nucleosides/*pharmacology
Phosphorous Acids/*pharmacology
Viruses/*drug effects
Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Carbohydrate Conformation ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Microbial Sensitivity Tests ; Nucleosides/chemical synthesis ; Nucleosides/chemistry ; Phosphorous Acids/chemical synthesis ; Phosphorous Acids/chemistry
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 3 3.

Tytuł :: Recent advances in the development of allosteric protein tyrosine phosphatase inhibitors for drug discovery.
Autorzy :: Elhassan RM; Department of Medicinal Chemistry and Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmacy, Shandong University, Jinan, Shandong, China.
Hou X; Department of Medicinal Chemistry and Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmacy, Shandong University, Jinan, Shandong, China.
Fang H; Department of Medicinal Chemistry and Key Laboratory of Chemical Biology of Natural Products (MOE), School of Pharmacy, Shandong University, Jinan, Shandong, China.; Pokaż więcej
Źródło :: Medicinal research reviews [Med Res Rev] 2022 May; Vol. 42 (3), pp. 1064-1110. Date of Electronic Publication: 2021 Nov 17.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
Protein Tyrosine Phosphatases*/chemistry
Protein Tyrosine Phosphatases*/metabolism
Drug Discovery ; Humans ; Signal Transduction ; Structure-Activity Relationship
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 4 4.

Tytuł :: Identification of 11β-HSD1 inhibitors through enhanced sampling methods.
Autorzy :: Singh R; Structural Bioinformatics Lab, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, HP, 176061, India. .; Biotechnology division, CSIR-IHBT, Palampur, HP, 176061, India.; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad-201002, India.
Bhardwaj VK; Structural Bioinformatics Lab, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, HP, 176061, India. .; Biotechnology division, CSIR-IHBT, Palampur, HP, 176061, India.; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad-201002, India.
Das P; Biotechnology division, CSIR-IHBT, Palampur, HP, 176061, India.; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad-201002, India.; Natural Product Chemistry and Process Development, CSIR-IHBT, Palampur, HP, 176061, India.
Purohit R; Structural Bioinformatics Lab, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, HP, 176061, India. .; Biotechnology division, CSIR-IHBT, Palampur, HP, 176061, India.; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad-201002, India.; Pokaż więcej
Źródło :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2022 Apr 19; Vol. 58 (32), pp. 5005-5008. Date of Electronic Publication: 2022 Apr 19.
Typ publikacji :: Journal Article
MeSH Terms :: 11-beta-Hydroxysteroid Dehydrogenase Type 1*/chemistry
11-beta-Hydroxysteroid Dehydrogenase Type 1*/metabolism
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 5 5.

Tytuł :: A novel strategy for screening angiotensin-converting enzyme inhibitors from natural products based on enzyme-immobilized ligand fishing combined with active-site blocking and directional enrichment.
Autorzy :: Luo H; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, PR China.
Qian Y; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, PR China.
Qi J; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address: .
Liu X; Department of Medical Information and Biostatistics, School of Science, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address: .; Pokaż więcej
Źródło :: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2022 Apr 15; Vol. 1195, pp. 123203. Date of Electronic Publication: 2022 Mar 02.
Typ publikacji :: Journal Article
MeSH Terms :: Angiotensin-Converting Enzyme Inhibitors*/analysis
Angiotensin-Converting Enzyme Inhibitors*/chemistry
Angiotensin-Converting Enzyme Inhibitors*/metabolism
Enzymes, Immobilized*/antagonists & inhibitors
Enzymes, Immobilized*/metabolism
Biological Products/*chemistry
Peptidyl-Dipeptidase A/*metabolism
Chromatography, High Pressure Liquid ; Ligands ; Magnetite Nanoparticles/chemistry ; Molecular Docking Simulation ; Tandem Mass Spectrometry
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: Exploring Unconventional SAM Analogues To Build Cell-Potent Bisubstrate Inhibitors for Nicotinamide N-Methyltransferase.
Autorzy :: Iyamu ID; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute for Drug Discovery, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
Vilseck JZ; Department of Biochemistry and Molecular Biology, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Yadav R; Department of Biological Sciences, Markey Center for Structural Biology, and the Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907, USA.
Noinaj N; Department of Biological Sciences, Markey Center for Structural Biology, and the Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907, USA.
Huang R; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute for Drug Discovery, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.; Pokaż więcej
Źródło :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2022 Apr 11; Vol. 61 (16), pp. e202114813. Date of Electronic Publication: 2022 Feb 23.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :: Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
Nicotinamide N-Methyltransferase*/chemistry
Nicotinamide N-Methyltransferase*/metabolism
Methyltransferases/metabolism ; Niacinamide/pharmacology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 7 7.

Tytuł :: Critical Assessment of a Structure-Based Screening Campaign for IDO1 Inhibitors: Tips and Pitfalls.
Autorzy :: Mammoli A; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo n.1, 06123 Perugia, Italy.
Bianconi E; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo n.1, 06123 Perugia, Italy.
Ruta L; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo n.1, 06123 Perugia, Italy.
Riccio A; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo n.1, 06123 Perugia, Italy.
Bigiotti C; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo n.1, 06123 Perugia, Italy.
Souma M; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo n.1, 06123 Perugia, Italy.
Carotti A; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo n.1, 06123 Perugia, Italy.
Rossini S; Department of Medicine and Surgery, University of Perugia, P.le Gambuli, 06132 Perugia, Italy.
Suvieri C; Department of Medicine and Surgery, University of Perugia, P.le Gambuli, 06132 Perugia, Italy.
Pallotta MT; Department of Medicine and Surgery, University of Perugia, P.le Gambuli, 06132 Perugia, Italy.
Grohmann U; Department of Medicine and Surgery, University of Perugia, P.le Gambuli, 06132 Perugia, Italy.
Camaioni E; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo n.1, 06123 Perugia, Italy.
Macchiarulo A; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo n.1, 06123 Perugia, Italy.; Pokaż więcej
Źródło :: International journal of molecular sciences [Int J Mol Sci] 2022 Apr 02; Vol. 23 (7). Date of Electronic Publication: 2022 Apr 02.
Typ publikacji :: Journal Article
MeSH Terms :: Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
Indoleamine-Pyrrole 2,3,-Dioxygenase*/metabolism
Ligands ; Molecular Conformation ; Structure-Activity Relationship
: Czasopismo naukowe

Szczegóły Pełny tekst

Skocz do pozycji: 8 8.

Tytuł :: Renin Angiotensin Blockers and Cardiac Protection: From Basis to Clinical Trials.
Autorzy :: Lévy BI; Inserm U970, PARRC, Hôpital Lariboisière, Paris, France.
Mourad JJ; Hôpital St Joseph, Paris, France.; Pokaż więcej
Źródło :: American journal of hypertension [Am J Hypertens] 2022 Apr 02; Vol. 35 (4), pp. 293-302.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Angiotensin-Converting Enzyme Inhibitors*/pharmacology
Angiotensin-Converting Enzyme Inhibitors*/therapeutic use
Renin*
Angiotensin II Type 1 Receptor Blockers/adverse effects ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Angiotensin Receptor Antagonists/adverse effects ; Angiotensin Receptor Antagonists/pharmacology ; Angiotensin Receptor Antagonists/therapeutic use ; Angiotensins ; Humans ; Renin-Angiotensin System/drug effects
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: Production of Dual Inhibitory Hydrolysate by Enzymatic Hydrolysis of Squid Processing By-product.
Autorzy :: Liu Q; College of Food Science and Engineering, South China University of Technology, Guangzhou, China.; Guangzhou Institute of Modern Industrial Technology, Guangzhou, China.
Yao Y; College of Food Science and Engineering, South China University of Technology, Guangzhou, China.
Ibrahim MAA; Department of Chemistry, Faculty of Science, Minia University, Minya, Egypt.
Halawany AME; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Giza, Egypt.
Yang L; College of Food Science and Engineering, South China University of Technology, Guangzhou, China. .; Guangzhou Institute of Modern Industrial Technology, Guangzhou, China. .
Zhang X; College of Food Science and Engineering, South China University of Technology, Guangzhou, China. .; Guangzhou Institute of Modern Industrial Technology, Guangzhou, China. .; Pokaż więcej
Źródło :: Marine biotechnology (New York, N.Y.) [Mar Biotechnol (NY)] 2022 Apr; Vol. 24 (2), pp. 293-302. Date of Electronic Publication: 2022 Mar 11.
Typ publikacji :: Journal Article
MeSH Terms :: Angiotensin-Converting Enzyme Inhibitors*/chemistry
Angiotensin-Converting Enzyme Inhibitors*/pharmacology
Protein Hydrolysates*/chemistry
Animals ; Decapodiformes/metabolism ; Hydrolysis ; Peptide Hydrolases/metabolism ; Renin
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 10 10.

Tytuł :: Design, synthesis and biological evaluation of 1,3,4-triazole-3-acetamide derivatives as potent neuraminidase inhibitors.
Autorzy :: Shi L; School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China.
Zhang XY; School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China.
Cheng LP; School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China. Electronic address: .; Pokaż więcej
Źródło :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Apr 01; Vol. 61, pp. 128590. Date of Electronic Publication: 2022 Jan 30.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Drug Design*
Acetamides/*pharmacology
Enzyme Inhibitors/*pharmacology
Neuraminidase/*antagonists & inhibitors
Triazoles/*pharmacology
Acetamides/chemical synthesis ; Acetamides/chemistry ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Molecular Structure ; Neuraminidase/metabolism ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/chemistry
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 11 11.

Tytuł :: Linezolid Metabolism Is Catalyzed by Cytochrome P450 2J2, 4F2, and 1B1.
Autorzy :: Obach RS; Pfizer Inc., Groton, Connecticut .; Pokaż więcej
Źródło :: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2022 Apr; Vol. 50 (4), pp. 413-421. Date of Electronic Publication: 2022 Jan 18.
Typ publikacji :: Journal Article
MeSH Terms :: Cytochrome P-450 Enzyme Inhibitors*/metabolism
Cytochrome P-450 Enzyme Inhibitors*/pharmacology
Cytochrome P-450 Enzyme System*/metabolism
Catalysis ; Humans ; Linezolid/metabolism ; Microsomes, Liver/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 12 12.

Tytuł :: Discovery and characterization of amentoflavone as a naturally occurring inhibitor against the bile salt hydrolase produced by Lactobacillus salivarius .
Autorzy :: Li CY; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. .
Wang HN; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. .
He RJ; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. .
Huang J; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. .; Pharmacology and Toxicology Division, Shanghai Institute of Food and Drug Control, Shanghai 201203, China.
Song LL; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116000, China.
Song YQ; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. .
Huo PC; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. .
Hou J; College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Ji G; Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. .
Ge GB; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. .; Pokaż więcej
Źródło :: Food & function [Food Funct] 2022 Mar 21; Vol. 13 (6), pp. 3318-3328. Date of Electronic Publication: 2022 Mar 21.
Typ publikacji :: Journal Article
MeSH Terms :: Amidohydrolases/*antagonists & inhibitors
Biflavonoids/*pharmacology
Enzyme Inhibitors/*pharmacology
Lactobacillus salivarius/*enzymology
Amidohydrolases/chemistry ; Amidohydrolases/metabolism ; Animals ; Biflavonoids/chemistry ; Biflavonoids/metabolism ; Catalytic Domain ; Drug Evaluation, Preclinical ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/metabolism ; Feces/enzymology ; Kinetics ; Mice ; Molecular Docking Simulation
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 13 13.

Tytuł :: Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors.
Autorzy :: Zhang TJ; School of Pharmacy, China Medical University, 77 Puhe Road, North New Area, Shenyang 110122, China.
Zhang Y; School of Pharmacy, China Medical University, 77 Puhe Road, North New Area, Shenyang 110122, China.
Zhang ZH; School of Pharmacy, China Medical University, 77 Puhe Road, North New Area, Shenyang 110122, China.
Wang ZR; School of Pharmacy, China Medical University, 77 Puhe Road, North New Area, Shenyang 110122, China.
Zhang X; School of Pharmacy, China Medical University, 77 Puhe Road, North New Area, Shenyang 110122, China.
Hu SS; School of Pharmacy, China Medical University, 77 Puhe Road, North New Area, Shenyang 110122, China.
Lu PF; School of Pharmacy, China Medical University, 77 Puhe Road, North New Area, Shenyang 110122, China.
Guo S; School of Pharmacy, China Medical University, 77 Puhe Road, North New Area, Shenyang 110122, China.
Meng FH; School of Pharmacy, China Medical University, 77 Puhe Road, North New Area, Shenyang 110122, China. Electronic address: .; Pokaż więcej
Źródło :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Mar 15; Vol. 60, pp. 128582. Date of Electronic Publication: 2022 Jan 22.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Drug Discovery*
Enzyme Inhibitors/*pharmacology
Triazoles/*pharmacology
Xanthine Oxidase/*antagonists & inhibitors
Animals ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Hyperuricemia/chemically induced ; Hyperuricemia/drug therapy ; Hyperuricemia/metabolism ; Ligands ; Models, Molecular ; Molecular Structure ; Oxonic Acid ; Rats ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/chemistry ; Uric Acid/antagonists & inhibitors ; Uric Acid/blood ; Xanthine Oxidase/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 14 14.

Tytuł :: The effects of angiotensin I-converting enzyme inhibitory peptide VGINYW and the hydrolysate of α-lactalbumin on blood pressure, oxidative stress and gut microbiota of spontaneously hypertensive rats.
Autorzy :: Xie D; State Key Laboratory of Bioreactor Engineering; Department of Food Science and Technology, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, P. R. China. .
Shen Y; State Key Laboratory of Bioreactor Engineering; Department of Food Science and Technology, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, P. R. China. .
Su E; College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, China.
Du L; State Key Laboratory of Bioreactor Engineering; Department of Food Science and Technology, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, P. R. China. .
Xie J; State Key Laboratory of Bioreactor Engineering; Department of Food Science and Technology, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, P. R. China. .; Shanghai Collaborative Innovation Center for Biomanufacturing (SCICB), Shanghai 200237, P. R. China.
Wei D; State Key Laboratory of Bioreactor Engineering; Department of Food Science and Technology, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, P. R. China. .; Shanghai Collaborative Innovation Center for Biomanufacturing (SCICB), Shanghai 200237, P. R. China.; Pokaż więcej
Źródło :: Food & function [Food Funct] 2022 Mar 07; Vol. 13 (5), pp. 2743-2755. Date of Electronic Publication: 2022 Mar 07.
Typ publikacji :: Journal Article
MeSH Terms :: Lactalbumin*
Angiotensin-Converting Enzyme Inhibitors/*pharmacology
Antihypertensive Agents/*pharmacology
Protein Hydrolysates/*pharmacology
Angiotensin-Converting Enzyme Inhibitors/chemistry ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Animals ; Antihypertensive Agents/chemistry ; Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Disease Models, Animal ; Gastrointestinal Microbiome/drug effects ; Hypertension/prevention & control ; Male ; Oxidative Stress/drug effects ; Protein Hydrolysates/chemistry ; Protein Hydrolysates/therapeutic use ; Rats ; Rats, Inbred SHR ; Specific Pathogen-Free Organisms
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 15 15.

Tytuł :: Structure-based discovery of (S)-2-amino-6-(4-fluorobenzyl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione as low nanomolar, orally bioavailable autotaxin inhibitor.
Autorzy :: Roy A; TCG Lifesciences Pvt. Ltd., Kolkata, India.
Sarkar T; TCG Lifesciences Pvt. Ltd., Kolkata, India.
Datta S; TCG Lifesciences Pvt. Ltd., Kolkata, India.
Maiti A; TCG Lifesciences Pvt. Ltd., Kolkata, India.
Chakrabarti M; TCG Lifesciences Pvt. Ltd., Kolkata, India.
Mondal T; TCG Lifesciences Pvt. Ltd., Kolkata, India.
Mondal C; TCG Lifesciences Pvt. Ltd., Kolkata, India.
Banerjee A; TCG Lifesciences Pvt. Ltd., Kolkata, India.
Roy S; TCG Lifesciences Pvt. Ltd., Kolkata, India.
Mukherjee S; TCG Lifesciences Pvt. Ltd., Kolkata, India.
Muley P; TCG Lifesciences Pvt. Ltd., Kolkata, India.
Chakraborty S; TCG Lifesciences Pvt. Ltd., Kolkata, India.
Banerjee M; TCG Lifesciences Pvt. Ltd., Kolkata, India.
Kundu M; TCG Lifesciences Pvt. Ltd., Kolkata, India.
Roy KK; Department of Pharmaceutical Sciences, School of Health Sciences, UPES, Dehradun, India.; Pokaż więcej
Źródło :: Chemical biology & drug design [Chem Biol Drug Des] 2022 Mar; Vol. 99 (3), pp. 496-503. Date of Electronic Publication: 2022 Jan 03.
Typ publikacji :: Journal Article
MeSH Terms :: Drug Design*
Enzyme Inhibitors/*chemistry
Indoles/*chemistry
Phosphoric Diester Hydrolases/*chemistry
Administration, Oral ; Animals ; Binding Sites ; Drug Stability ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacokinetics ; Half-Life ; Humans ; Imidazoles/chemistry ; Indoles/metabolism ; Indoles/pharmacokinetics ; Microsomes, Liver/metabolism ; Molecular Docking Simulation ; Phosphoric Diester Hydrolases/metabolism ; Pyridines/chemistry ; Rats ; Rats, Sprague-Dawley ; Stereoisomerism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 16 16.

Tytuł :: Design, synthesis and biological evaluation of novel 1, 3, 4-oxadiazole derivatives as potent neuraminidase inhibitors.
Autorzy :: Yu W; School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China.
Ping Cheng L; School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China. Electronic address: .
Pang W; School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China.
Ling Guo L; School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China.; Pokaż więcej
Źródło :: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Mar 01; Vol. 57, pp. 116647. Date of Electronic Publication: 2022 Jan 30.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Drug Design*
Antiviral Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Neuraminidase/*antagonists & inhibitors
Orthomyxoviridae/*drug effects
Oxadiazoles/*pharmacology
Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Molecular Structure ; Neuraminidase/metabolism ; Oxadiazoles/chemical synthesis ; Oxadiazoles/chemistry ; Structure-Activity Relationship
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 17 17.

Tytuł :: Recent applications of seven-membered rings in drug design.
Autorzy :: Ouvry G; Evotec (U.K.) Ltd., 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 4RZ, UK.; Pokaż więcej
Źródło :: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Mar 01; Vol. 57, pp. 116650. Date of Electronic Publication: 2022 Jan 31.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Drug Design*
Enzyme Inhibitors/*pharmacology
Heterocyclic Compounds, 4 or More Rings/*pharmacology
Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Heterocyclic Compounds, 4 or More Rings/chemical synthesis ; Heterocyclic Compounds, 4 or More Rings/chemistry ; Molecular Structure
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 18 18.

Tytuł :: Separation and identification of ACE inhibitory peptides from lizard fish proteins hydrolysates by metal affinity-immobilized magnetic liposome.
Autorzy :: Lu Y; Medical College, Guangxi University of Science and Technology, Liuzhou, 545006, China.
Wu Y; Medical College, Guangxi University of Science and Technology, Liuzhou, 545006, China.
Hou X; Medical College, Guangxi University of Science and Technology, Liuzhou, 545006, China.
Lu Y; Medical College, Guangxi University of Science and Technology, Liuzhou, 545006, China.
Meng H; Medical College, Guangxi University of Science and Technology, Liuzhou, 545006, China.
Pei S; Medical College, Guangxi University of Science and Technology, Liuzhou, 545006, China.
Dai Z; Medical College, Guangxi University of Science and Technology, Liuzhou, 545006, China.
Wu S; Medical College, Guangxi University of Science and Technology, Liuzhou, 545006, China. Electronic address: .; Pokaż więcej
Źródło :: Protein expression and purification [Protein Expr Purif] 2022 Mar; Vol. 191, pp. 106027. Date of Electronic Publication: 2021 Nov 25.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Angiotensin-Converting Enzyme Inhibitors*/chemistry
Angiotensin-Converting Enzyme Inhibitors*/isolation & purification
Fishes*
Peptides*/chemistry
Peptides*/isolation & purification
Fish Proteins/*chemistry
Protein Hydrolysates/*chemistry
Animals ; Chromatography, Affinity ; Liposomes/chemistry ; Magnetic Phenomena
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 19 19.

Tytuł :: Diaryl triazenes inhibit cytochrome P450 1A1 and 1B1 more strongly than aryl morpholino triazenes.
Autorzy :: Moran R; Department of Chemistry, Whittier College, Whittier, CA 90608, United States. Electronic address: .
Nakamura R; Department of Chemistry, Whittier College, Whittier, CA 90608, United States. Electronic address: .
Isovitsch R; Department of Chemistry, Whittier College, Whittier, CA 90608, United States. Electronic address: .
Iimoto D; Department of Chemistry, Whittier College, Whittier, CA 90608, United States. Electronic address: .; Pokaż więcej
Źródło :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Mar 01; Vol. 59, pp. 128570. Date of Electronic Publication: 2022 Jan 19.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Cytochrome P-450 CYP1A1/*antagonists & inhibitors
Cytochrome P-450 CYP1B1/*antagonists & inhibitors
Cytochrome P-450 Enzyme Inhibitors/*pharmacology
Morpholinos/*pharmacology
Triazenes/*pharmacology
Cytochrome P-450 CYP1A1/metabolism ; Cytochrome P-450 CYP1B1/metabolism ; Cytochrome P-450 Enzyme Inhibitors/chemical synthesis ; Cytochrome P-450 Enzyme Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Molecular Structure ; Morpholinos/chemical synthesis ; Morpholinos/chemistry ; Structure-Activity Relationship ; Triazenes/chemical synthesis ; Triazenes/chemistry
: Czasopismo naukowe

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Skocz do pozycji: 20 20.

Tytuł :: In vitro metabolism of helenalin and its inhibitory effect on human cytochrome P450 activity.
Autorzy :: Šadibolová M; Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic.
Juvonen RO; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Auriola S; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Boušová I; Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic. .; Pokaż więcej
Źródło :: Archives of toxicology [Arch Toxicol] 2022 Mar; Vol. 96 (3), pp. 793-808. Date of Electronic Publication: 2022 Jan 06.
Typ publikacji :: Journal Article
MeSH Terms :: Cytochrome P-450 Enzyme Inhibitors/*metabolism
Cytochrome P-450 Enzyme System/*metabolism
Microsomes, Liver/*metabolism
Sesquiterpenes, Guaiane/*metabolism
Animals ; Cytochrome P-450 Enzyme Inhibitors/administration & dosage ; Cytochrome P-450 Enzyme Inhibitors/pharmacology ; Cytochrome P-450 Enzyme System/drug effects ; Female ; Humans ; Inhibitory Concentration 50 ; Male ; NADP/metabolism ; Rats ; Rats, Wistar ; Sesquiterpenes, Guaiane/administration & dosage ; Sesquiterpenes, Guaiane/pharmacology ; Species Specificity
: Czasopismo naukowe

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