Temat: "Enzyme Inhibitors" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Effects of the angiotensin-converting enzyme inhibitor captopril on occlusal-disharmony-induced cardiac dysfunction in mice.
Autorzy:: Ito A; Department of Orthodontics, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan.
Ohnuki Y; Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan.
Suita K; Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan.
Matsuo I; Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan.
Ishikawa M; Department of Oral Anatomy, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan.
Mitsubayashi T; Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan.
Mototani Y; Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan.
Kiyomoto K; Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan.; Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan.
Tsunoda M; Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan.; Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan.
Morii A; Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan.; Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan.
Nariyama M; Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine, Yokohama, 236-8501, Japan.
Hayakawa Y; Department of Dental Anesthesiology, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan.
Tomonari H; Department of Orthodontics, Tsurumi University School of Dental Medicine, Yokohama, 230-8501, Japan.
Okumura S; Department of Physiology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama, 230-8501, Japan. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Nov 15; Vol. 13 (1), pp. 19927. Date of Electronic Publication: 2023 Nov 15.
Typ publikacji:: Journal Article
MeSH Terms:: Angiotensin-Converting Enzyme Inhibitors*/pharmacology
Heart Failure*
Humans ; Mice ; Animals ; Captopril/pharmacology ; Heart ; Myocardium ; Enzyme Inhibitors

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Tytuł:: The association of withholding or continuing angiotensin-converting enzyme inhibitors or angiotensin 2 receptor blockers on acute kidney injury after non-cardiac surgery.
Autorzy:: Choi J; Department of Anaesthesiology and Pain Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Ryu DK; Department of Anaesthesiology and Pain Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Woo S; Department of Anaesthesiology and Pain Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Kim J; Department of Anaesthesiology and Pain Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Lee S; Department of Anaesthesiology and Pain Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Park B; Biomedical Statistics Centre, Research Institute for Future Medicine, Samsung Medical Centre, Seoul, South Korea.
Jeon K; Division of Respiratory and Critical Care Medicine, Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Park M; Department of Anaesthesiology and Pain Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, South Korea.; Pokaż więcej
Źródło:: Anaesthesia [Anaesthesia] 2024 Sep; Vol. 79 (9), pp. 937-944. Date of Electronic Publication: 2024 May 13.
Typ publikacji:: Journal Article
MeSH Terms:: Acute Kidney Injury*/chemically induced
Angiotensin-Converting Enzyme Inhibitors*/adverse effects
Angiotensin-Converting Enzyme Inhibitors*/therapeutic use
Postoperative Complications*
Humans ; Female ; Male ; Aged ; Middle Aged ; Creatinine/blood ; Angiotensin Receptor Antagonists/adverse effects ; Angiotensin Receptor Antagonists/therapeutic use ; Retrospective Studies ; Glomerular Filtration Rate/drug effects ; Surgical Procedures, Operative ; Withholding Treatment ; Adult ; Hypotension/chemically induced

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Tytuł:: Inhibition of soluble epoxide hydrolase by natural isothiocyanates.
Autorzy:: Elbarbry F; School of Pharmacy, Pacific University, 222 SE 8th Ave, Ste. 451, Hillsboro, OR, 97123, USA. Electronic address: .
Espiritu MJ; School of Pharmacy, Pacific University, 222 SE 8th Ave, Ste. 451, Hillsboro, OR, 97123, USA.
Soo K; School of Pharmacy, Pacific University, 222 SE 8th Ave, Ste. 451, Hillsboro, OR, 97123, USA.
Yee B; School of Pharmacy, Pacific University, 222 SE 8th Ave, Ste. 451, Hillsboro, OR, 97123, USA.
Taylor J; School of Pharmacy, Pacific University, 222 SE 8th Ave, Ste. 451, Hillsboro, OR, 97123, USA.; Pokaż więcej
Źródło:: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Sep 17; Vol. 725, pp. 150261. Date of Electronic Publication: 2024 Jun 12.
Typ publikacji:: Journal Article
MeSH Terms:: Epoxide Hydrolases*/antagonists & inhibitors
Epoxide Hydrolases*/metabolism
Epoxide Hydrolases*/chemistry
Isothiocyanates*/pharmacology
Isothiocyanates*/chemistry
Isothiocyanates*/metabolism
Molecular Docking Simulation*
Microsomes, Liver*/enzymology
Microsomes, Liver*/metabolism
Microsomes, Liver*/drug effects
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/chemistry
Humans ; Solubility

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Tytuł:: Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment.
Autorzy:: Nishigaya Y; Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co. Ltd., 1848 Nogi, Shimotsuga-gun, Tochigi 329-0114, Japan. Electronic address: .
Takase S; School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Sumiya T; Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co. Ltd., 1848 Nogi, Shimotsuga-gun, Tochigi 329-0114, Japan.
Sato T; Drug Discovery Computational Chemistry Platform Unit, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Niwa H; Drug Discovery Structural Biology Platform Unit, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Sato S; Drug Discovery Structural Biology Platform Unit, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Nakata A; Drug Discovery Seed Compounds Exploratory Unit, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Matsuoka S; Drug Discovery Seed Compounds Exploratory Unit, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Maemoto Y; School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Hashimoto N; Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co. Ltd., 1848 Nogi, Shimotsuga-gun, Tochigi 329-0114, Japan.
Namie R; Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co. Ltd., 1848 Nogi, Shimotsuga-gun, Tochigi 329-0114, Japan.
Honma T; Drug Discovery Computational Chemistry Platform Unit, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Umehara T; Drug Discovery Structural Biology Platform Unit, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Shirouzu M; Drug Discovery Structural Biology Platform Unit, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Koyama H; Drug Discovery Chemistry Platform Unit, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Yoshida M; Drug Discovery Seed Compounds Exploratory Unit, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; Office of University Professor, the University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Ito A; Drug Discovery Seed Compounds Exploratory Unit, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Shirai F; Drug Discovery Chemistry Platform Unit, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. Electronic address: .; Pokaż więcej
Źródło:: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Sep 15; Vol. 110, pp. 129856. Date of Electronic Publication: 2024 Jun 22.
Typ publikacji:: Journal Article
MeSH Terms:: Histone-Lysine N-Methyltransferase*/antagonists & inhibitors
Histone-Lysine N-Methyltransferase*/metabolism
Anemia, Sickle Cell*/drug therapy
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/chemical synthesis
Epigenesis, Genetic*/drug effects
Humans ; Structure-Activity Relationship ; Molecular Structure ; Histocompatibility Antigens/metabolism ; Dose-Response Relationship, Drug ; Crystallography, X-Ray

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Tytuł:: Screening and rational identification of a novel angiotensin-converting enzyme C-domain inhibitory peptide from Fabaceae food peptide library.
Autorzy:: Ho TY; Graduate Institute of Chinese Medicine, China Medical University, Taichung 404328, Taiwan; Department of Health and Nutrition Biotechnology, Asia University, Taichung 413305, Taiwan.
Lo HY; Graduate Institute of Chinese Medicine, China Medical University, Taichung 404328, Taiwan.
Lu GL; School of Medicine, China Medical University, Taichung 404328, Taiwan.
Lin CY; Department of Internal Medicine, China Medical University Hospital, Taichung 404327, Taiwan.
Stevens ML; Graduate Institute of Chinese Medicine, China Medical University, Taichung 404328, Taiwan.
Chen CC; Graduate Institute of Chinese Medicine, China Medical University, Taichung 404328, Taiwan.
Hsiang CY; School of Medicine, China Medical University, Taichung 404328, Taiwan.. Electronic address: .; Pokaż więcej
Źródło:: Food chemistry [Food Chem] 2024 Sep 15; Vol. 452, pp. 139540. Date of Electronic Publication: 2024 May 06.
Typ publikacji:: Journal Article
MeSH Terms:: Angiotensin-Converting Enzyme Inhibitors*/chemistry
Angiotensin-Converting Enzyme Inhibitors*/pharmacology
Fabaceae*/chemistry
Peptidyl-Dipeptidase A*/chemistry
Peptidyl-Dipeptidase A*/metabolism
Peptides*/chemistry
Peptides*/pharmacology
Plant Proteins*/chemistry
Peptide Library*
Animals ; Rats ; Male ; Antihypertensive Agents/chemistry ; Antihypertensive Agents/pharmacology ; Humans ; Blood Pressure/drug effects ; Hypertension/drug therapy ; Hypertension/physiopathology ; Hypertension/metabolism ; Rats, Sprague-Dawley

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Tytuł:: Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer.
Autorzy:: Sharma H; Department of Pharmaceutical Sciences, College of Pharmacy, Southwestern Oklahoma State University, Weatherford, OK, USA. Electronic address: .
Mondal S; Department of Pharmaceutical Sciences, College of Pharmacy, Southwestern Oklahoma State University, Weatherford, OK, USA.
Urquiza U; Department of Biological & Biomedical Sciences, Southwestern Oklahoma State University, Weatherford, OK, USA.
Esparza C; Department of Biological & Biomedical Sciences, Southwestern Oklahoma State University, Weatherford, OK, USA.
Bartlett S; Department of Pharmaceutical Sciences, College of Pharmacy, Southwestern Oklahoma State University, Weatherford, OK, USA.
Santa-Pinter L; Department of Pharmaceutical Sciences, College of Pharmacy, Southwestern Oklahoma State University, Weatherford, OK, USA.
Hill H; Department of Biological & Biomedical Sciences, Southwestern Oklahoma State University, Weatherford, OK, USA.
White M; Department of Biological & Biomedical Sciences, Southwestern Oklahoma State University, Weatherford, OK, USA.
Sharma P; Department of Biological & Biomedical Sciences, Southwestern Oklahoma State University, Weatherford, OK, USA.
Luckett-Chastain L; Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Cooper A; Protein Structure and X-ray Crystallography Laboratory, The University of Kansas, Lawrence, KS, USA.
Rasel M; Protein Structure and X-ray Crystallography Laboratory, The University of Kansas, Lawrence, KS, USA.
Gao P; Protein Production Group, The University of Kansas, Lawrence, KS, USA.
Battaile KP; New York Structural Biology Center, Upton, NY, USA.
Shukla SK; Department of Oncology Science, OU College of Medicine, Oklahoma City, USA.
Lovell S; Protein Structure and X-ray Crystallography Laboratory, The University of Kansas, Lawrence, KS, USA.
Ihnat MA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, USA.; Pokaż więcej
Źródło:: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116598. Date of Electronic Publication: 2024 Jun 17.
Typ publikacji:: Journal Article
MeSH Terms:: Pancreatic Neoplasms*/drug therapy
Pancreatic Neoplasms*/pathology
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/chemistry
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/chemical synthesis
Enzyme Inhibitors*/chemistry
Cell Proliferation*/drug effects
Humans ; Animals ; Administration, Oral ; Mice ; Structure-Activity Relationship ; Molecular Structure ; Drug Screening Assays, Antitumor ; Biological Availability ; Dose-Response Relationship, Drug ; L-Lactate Dehydrogenase/antagonists & inhibitors ; L-Lactate Dehydrogenase/metabolism ; Cell Line, Tumor ; Models, Molecular

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Tytuł:: Discovery of novel natural-product-derived mutant isocitrate dehydrogenases 1 inhibitors: Structure-based virtual screening, biological evaluation and structure-activity relationship study.
Autorzy:: Xu T; Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, PR China.
Yang J; Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, PR China.
Li D; Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, PR China.
Challa M; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China.
Zou C; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China.
Deng P; Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, PR China. Electronic address: .
Zhang SL; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China. Electronic address: .
Xu B; Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing, 400016, PR China. Electronic address: .; Pokaż więcej
Źródło:: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116610. Date of Electronic Publication: 2024 Jun 17.
Typ publikacji:: Journal Article
MeSH Terms:: Isocitrate Dehydrogenase*/antagonists & inhibitors
Isocitrate Dehydrogenase*/genetics
Isocitrate Dehydrogenase*/metabolism
Biological Products*/pharmacology
Biological Products*/chemistry
Biological Products*/chemical synthesis
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/chemical synthesis
Cell Proliferation*/drug effects
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/chemical synthesis
Drug Discovery*
Drug Screening Assays, Antitumor*
Dose-Response Relationship, Drug*
Humans ; Structure-Activity Relationship ; Animals ; Mice ; Molecular Structure ; Mutation ; Cell Line, Tumor ; Drug Evaluation, Preclinical ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology ; Neoplasms, Experimental/metabolism

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Tytuł:: Design and synthesis of 6-C-alkyl-DMDP type nanomolar inhibitors of β-galactosidase and β-glucosidase based on broussonetine S and related derivatives.
Autorzy:: Gao FT; Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Wu QK; Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China; School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China.
Zhang M; Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Shimadate Y; Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Qian G; Qilu University of Technology (Shandong Academy of Sciences), Shandong Analysis and Test Center, Laboratory of Immunology for Environment and Health, Jinan, 250014, Shandong, China.
Song YY; Qilu University of Technology (Shandong Academy of Sciences), Shandong Analysis and Test Center, Laboratory of Immunology for Environment and Health, Jinan, 250014, Shandong, China.
Kato A; Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. Electronic address: .
Li YX; Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: .
Jia YM; Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Fleet GWJ; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
Yu CY; Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: .; Pokaż więcej
Źródło:: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116570. Date of Electronic Publication: 2024 Jun 06.
Typ publikacji:: Journal Article
MeSH Terms:: beta-Galactosidase*/antagonists & inhibitors
beta-Galactosidase*/metabolism
Drug Design*
Molecular Docking Simulation*
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/chemical synthesis
Enzyme Inhibitors*/chemistry
beta-Glucosidase*/antagonists & inhibitors
beta-Glucosidase*/metabolism
Cattle ; Animals ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Glycoside Hydrolase Inhibitors/pharmacology ; Glycoside Hydrolase Inhibitors/chemical synthesis ; Glycoside Hydrolase Inhibitors/chemistry

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Tytuł:: Advances in SHP2 tunnel allosteric inhibitors and bifunctional molecules.
Autorzy:: Guo Z; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China.
Duan Y; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China.
Sun K; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China.
Zheng T; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China.
Liu J; Department of Organic Chemistry, School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China. Electronic address: .
Xu S; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China. Electronic address: .
Xu J; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, Jiangsu, 211198, China. Electronic address: .; Pokaż więcej
Źródło:: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116579. Date of Electronic Publication: 2024 Jun 13.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Protein Tyrosine Phosphatase, Non-Receptor Type 11*/antagonists & inhibitors
Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/chemical synthesis
Humans ; Allosteric Regulation/drug effects ; Molecular Structure ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Neoplasms/drug therapy ; Neoplasms/pathology ; Structure-Activity Relationship ; Animals

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Tytuł:: Structure and Inhibition of Insect UDP- N -acetylglucosamine Pyrophosphorylase: A Key Enzyme in the Hexosamine Biosynthesis Pathway.
Autorzy:: Lu Q; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024, China.
Zhou Y; School of Software, Dalian University of Technology, Dalian 116024, China.
Ding Y; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024, China.
Cui Y; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024, China.
Li W; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024, China.
Liu T; MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024, China.; Pokaż więcej
Źródło:: Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Sep 04; Vol. 72 (35), pp. 19286-19294. Date of Electronic Publication: 2024 Jul 22.
Typ publikacji:: Journal Article
MeSH Terms:: Spodoptera*
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
Insect Proteins*/metabolism
Insect Proteins*/chemistry
Insect Proteins*/genetics
Insect Proteins*/antagonists & inhibitors
Hexosamines*/chemistry
Hexosamines*/metabolism
Hexosamines*/biosynthesis
Animals ; Nucleotidyltransferases/chemistry ; Nucleotidyltransferases/metabolism ; Nucleotidyltransferases/antagonists & inhibitors ; Nucleotidyltransferases/genetics ; Biosynthetic Pathways ; Binding Sites

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Tytuł:: Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Is Associated With a Reduced Risk of Poststroke Epilepsy in Patients With Ischemic Stroke.
Autorzy:: Chang KC; Department of Neurology Neurological Institute, Taichung Veterans General Hospital Taichung City Taiwan.
Lin CH; Department of Medical Research Taichung Veterans General Hospital Taichung City Taiwan.
Huang JA; Department of Neurology Neurological Institute, Taichung Veterans General Hospital Taichung City Taiwan.; Department of Health Business Administration Hungkuang University Taichung City Taiwan.; Pokaż więcej
Źródło:: Journal of the American Heart Association [J Am Heart Assoc] 2024 Sep 03; Vol. 13 (17), pp. e035438. Date of Electronic Publication: 2024 Aug 27.
Typ publikacji:: Journal Article
MeSH Terms:: Angiotensin-Converting Enzyme Inhibitors*/therapeutic use
Angiotensin-Converting Enzyme Inhibitors*/adverse effects
Ischemic Stroke*/epidemiology
Ischemic Stroke*/diagnosis
Ischemic Stroke*/prevention & control
Angiotensin Receptor Antagonists*/therapeutic use
Angiotensin Receptor Antagonists*/adverse effects
Epilepsy*/drug therapy
Epilepsy*/epidemiology
Humans ; Male ; Female ; Retrospective Studies ; Aged ; Taiwan/epidemiology ; Middle Aged ; Risk Factors ; Risk Assessment ; Hypertension/drug therapy ; Hypertension/epidemiology ; Hypertension/complications ; Databases, Factual ; Aged, 80 and over ; Protective Factors

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Tytuł:: Prodrug Approach to Exploit (S)-Alanine Amide as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors.
Autorzy:: Milite C; Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.
Sarno G; Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.; PhD Program in Drug Discovery and Development, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.
Pacilio I; Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.; PhD Program in Drug Discovery and Development, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.
Cianciulli A; Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.; Present Address: Center for Drug Discovery and Development-DMPK, Aptuit, an Evotec Company, Via A. Fleming,4, 37135, Verona, Italy.
Viviano M; Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.
Iannelli G; Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.; Present Address: Institute of Organic Chemistry, University of Vienna, WähringerStraße38, 1090, Wien, Austria.
Gazzillo E; Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.; PhD Program in Drug Discovery and Development, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.
Feoli A; Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.
Cipriano A; Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.
Giovanna Chini M; Dipartimento di Bioscienze e Territorio, University of Molise, Contrada Fonte, Lappone, 86090 Isernia, Italy.
Castellano S; Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.
Bifulco G; Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.
Sbardella G; Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.; Pokaż więcej
Źródło:: ChemMedChem [ChemMedChem] 2024 Sep 02; Vol. 19 (17), pp. e202400139. Date of Electronic Publication: 2024 Jun 25.
Typ publikacji:: Journal Article
MeSH Terms:: Protein-Arginine N-Methyltransferases*/antagonists & inhibitors
Protein-Arginine N-Methyltransferases*/metabolism
Amides*/chemistry
Amides*/pharmacology
Amides*/chemical synthesis
Prodrugs*/pharmacology
Prodrugs*/chemistry
Prodrugs*/chemical synthesis
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/chemical synthesis
Arginine*/chemistry
Arginine*/pharmacology
Alanine*/chemistry
Alanine*/pharmacology
Alanine*/analogs & derivatives
Humans ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Drug Development

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Tytuł:: Fluorescent covalent organic framework as an ultrasensitive fluorescent probe for tyrosinase activity monitoring and inhibitor screening.
Autorzy:: Liu H; School of Science, Xihua University, Chengdu, 610039, China.
Liu W; Department of Clinical Laboratory, Zigong First People's Hospital, Zigong, 643000, Sichuan, China.
Li Y; School of Science, Xihua University, Chengdu, 610039, China.
Jiang X; School of Science, Xihua University, Chengdu, 610039, China.
Wang S; School of Science, Xihua University, Chengdu, 610039, China.
Zhang G; School of Science, Xihua University, Chengdu, 610039, China. Electronic address: .
Luo X; School of Science, Xihua University, Chengdu, 610039, China. Electronic address: .
Zhao Y; School of Science, Xihua University, Chengdu, 610039, China; Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province, Xihua University, Chengdu, 610039, China. Electronic address: .; Pokaż więcej
Źródło:: Analytica chimica acta [Anal Chim Acta] 2024 Sep 01; Vol. 1320, pp. 343026. Date of Electronic Publication: 2024 Jul 25.
Typ publikacji:: Journal Article
MeSH Terms:: Monophenol Monooxygenase*/antagonists & inhibitors
Monophenol Monooxygenase*/metabolism
Metal-Organic Frameworks*/chemistry
Fluorescent Dyes*/chemistry
Fluorescent Dyes*/chemical synthesis
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/chemistry
Humans ; Spectrometry, Fluorescence ; Limit of Detection ; Enzyme Assays/methods ; Pyrones

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Tytuł:: Design, synthesis and biological evaluation of naphthyl amide derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors.
Autorzy:: Yu Q; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Institute of Respiratory Health, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Song C; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Institute of Respiratory Health, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Bi L; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Zhao S; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China; The Research Units of West China, Chinese Academy of Medical Sciences, West China Hospital, Chengdu, Sichuan, China; State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Chengdu, Sichuan, China.
Lei Q; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Institute of Respiratory Health, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China; The Research Units of West China, Chinese Academy of Medical Sciences, West China Hospital, Chengdu, Sichuan, China; State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Chengdu, Sichuan, China.
Yang N; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Institute of Respiratory Health, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Chen H; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Institute of Respiratory Health, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China; The Research Units of West China, Chinese Academy of Medical Sciences, West China Hospital, Chengdu, Sichuan, China; State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Chengdu, Sichuan, China.
Wang Y; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Institute of Respiratory Health, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China; The Research Units of West China, Chinese Academy of Medical Sciences, West China Hospital, Chengdu, Sichuan, China; State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Chengdu, Sichuan, China.
He Y; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Institute of Respiratory Health, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China; The Research Units of West China, Chinese Academy of Medical Sciences, West China Hospital, Chengdu, Sichuan, China; State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Chengdu, Sichuan, China.
Deng H; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Institute of Respiratory Health, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China; The Research Units of West China, Chinese Academy of Medical Sciences, West China Hospital, Chengdu, Sichuan, China; State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Chengdu, Sichuan, China. Electronic address: .; Pokaż więcej
Źródło:: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Sep 01; Vol. 111, pp. 117844. Date of Electronic Publication: 2024 Jul 23.
Typ publikacji:: Journal Article
MeSH Terms:: Monoacylglycerol Lipases*/antagonists & inhibitors
Monoacylglycerol Lipases*/metabolism
Drug Design*
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/chemical synthesis
Enzyme Inhibitors*/chemistry
Amides*/chemistry
Amides*/pharmacology
Amides*/chemical synthesis
Cell Proliferation*/drug effects
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/chemistry
Humans ; Structure-Activity Relationship ; Cell Line, Tumor ; Molecular Structure ; Drug Screening Assays, Antitumor ; Naphthalenes/pharmacology ; Naphthalenes/chemical synthesis ; Naphthalenes/chemistry ; Dose-Response Relationship, Drug ; Molecular Docking Simulation

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Tytuł:: Identification of a novel xanthine oxidoreductase inhibitor for hyperuricemia treatment with high efficacy and safety profile.
Autorzy:: Li X; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China; Diabetes Research Center of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chen D; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China; Diabetes Research Center of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Qi C; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China; Diabetes Research Center of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yang Y; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Guo K; Department of Pharmaceutical Analysis, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Ma C; Department of Pharmaceutical Analysis, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Tian J; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China; Diabetes Research Center of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Li J; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China; Diabetes Research Center of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhang L; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Wang B; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of Drug Metabolism, Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: .
Xiao Z; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; State Key Laboratory of Digestive Health, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: .
Ye F; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China; Diabetes Research Center of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: .; Pokaż więcej
Źródło:: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Sep; Vol. 178, pp. 117223. Date of Electronic Publication: 2024 Aug 01.
Typ publikacji:: Journal Article
MeSH Terms:: Hyperuricemia*/drug therapy
Xanthine Dehydrogenase*/antagonists & inhibitors
Xanthine Dehydrogenase*/metabolism
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/adverse effects
Enzyme Inhibitors*/therapeutic use
Molecular Docking Simulation*
Uric Acid*/blood
Animals ; Mice ; Male ; Allopurinol/pharmacology ; Humans ; Mice, Inbred C57BL ; Disease Models, Animal ; Dose-Response Relationship, Drug

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Tytuł:: Decreased timing to vasospasm prophylaxis improves outcomes among patients with aneurysmal subarachnoid hemorrhage (aSAH) on prehospital CCBs, ARBs, or ACE-inhibitors.
Autorzy:: Frei D; Radiology Imaging Associates, 10700 East Geddes Ave Ste. 200, Englewood, CO 80112, United States; Swedish Medical Center, 501 East Hampden Ave, Englewood, CO 80113, United States.
Jarvis S; Injury Outcomes Network, 601 East Hampden Ave Ste. 100, Englewood, CO 80113, United States.
Pirahanchi Y; Swedish Medical Center, 501 East Hampden Ave, Englewood, CO 80113, United States.
Wenz N; Rocky Vista University, 8401 S Chambers Rd, Greenwood Village, CO 80112, United States.
Nieberlein A; Swedish Medical Center, 501 East Hampden Ave, Englewood, CO 80113, United States.
DiSalvo L; Swedish Medical Center, 501 East Hampden Ave, Englewood, CO 80113, United States.
Bar-Or D; Swedish Medical Center, 501 East Hampden Ave, Englewood, CO 80113, United States; Injury Outcomes Network, 601 East Hampden Ave Ste. 100, Englewood, CO 80113, United States. Electronic address: .; Pokaż więcej
Źródło:: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2024 Sep; Vol. 127, pp. 110768. Date of Electronic Publication: 2024 Jul 29.
Typ publikacji:: Journal Article
MeSH Terms:: Subarachnoid Hemorrhage*/complications
Subarachnoid Hemorrhage*/drug therapy
Vasospasm, Intracranial*/etiology
Vasospasm, Intracranial*/prevention & control
Angiotensin-Converting Enzyme Inhibitors*/therapeutic use
Angiotensin-Converting Enzyme Inhibitors*/administration & dosage
Calcium Channel Blockers*/administration & dosage
Calcium Channel Blockers*/therapeutic use
Angiotensin Receptor Antagonists*/administration & dosage
Angiotensin Receptor Antagonists*/therapeutic use
Humans ; Female ; Male ; Middle Aged ; Retrospective Studies ; Aged ; Treatment Outcome ; Adult ; Antihypertensive Agents/administration & dosage ; Antihypertensive Agents/therapeutic use ; Length of Stay/statistics & numerical data ; Time Factors

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Tytuł:: Non-nucleoside inhibitors of DNMT1 and DNMT3 for targeted cancer therapy.
Autorzy:: Chen T; UMR 8038 CNRS, U1268 INSERM, UFR de pharmacie, Université Paris cité, 75270, France.
Mahdadi S; UMR 8038 CNRS, U1268 INSERM, UFR de pharmacie, Université Paris cité, 75270, France.
Vidal M; UMR 8038 CNRS, U1268 INSERM, UFR de pharmacie, Université Paris cité, 75270, France; Toxicology, Cochin Hospital, HUPC, APHP, Paris 75014, France.
Desbène-Finck S; UMR 8038 CNRS, U1268 INSERM, UFR de pharmacie, Université Paris cité, 75270, France. Electronic address: .; Pokaż więcej
Źródło:: Pharmacological research [Pharmacol Res] 2024 Sep; Vol. 207, pp. 107328. Date of Electronic Publication: 2024 Jul 28.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Neoplasms*/drug therapy
Neoplasms*/genetics
DNA (Cytosine-5-)-Methyltransferase 1*/antagonists & inhibitors
DNA (Cytosine-5-)-Methyltransferase 1*/metabolism
Antineoplastic Agents*/therapeutic use
Antineoplastic Agents*/pharmacology
Enzyme Inhibitors*/therapeutic use
Enzyme Inhibitors*/pharmacology
Humans ; Animals ; DNA (Cytosine-5-)-Methyltransferases/antagonists & inhibitors ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; DNA Methylation/drug effects ; Molecular Targeted Therapy ; DNA Methyltransferase 3B ; DNA Methyltransferase 3A

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Tytuł:: Natural flavonoids as promising lactate dehydrogenase A inhibitors: Comprehensive in vitro and in silico analysis.
Autorzy:: Yırtıcı Ü; Department of Medical Laboratory, Kirikkale University, Kirikkale, Turkey.; Pokaż więcej
Źródło:: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Sep; Vol. 357 (9), pp. e2400455. Date of Electronic Publication: 2024 Jul 25.
Typ publikacji:: Journal Article
MeSH Terms:: Flavonoids*/pharmacology
Flavonoids*/chemistry
Flavonoids*/chemical synthesis
Molecular Docking Simulation*
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/chemical synthesis
Humans ; Structure-Activity Relationship ; L-Lactate Dehydrogenase/antagonists & inhibitors ; L-Lactate Dehydrogenase/metabolism ; Molecular Structure ; Computer Simulation ; Dose-Response Relationship, Drug

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Tytuł:: Identification of novel dual-target 4-hydroxyphenylpyruvate dioxygenase & phytoene dehydrogenase inhibitors via multiple virtual screening.
Autorzy:: Shi J; Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, PR China.
Gao S; Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of Agricultural Functional Molecule Design and Utilization of Heilongjiang Province, PR China.
Zhang PX; Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, PR China.
Zhang FH; Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, PR China.
Zhao LX; Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of Agricultural Functional Molecule Design and Utilization of Heilongjiang Province, PR China.
Ye F; Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of Agricultural Functional Molecule Design and Utilization of Heilongjiang Province, PR China. Electronic address: .
Fu Y; Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of Agricultural Functional Molecule Design and Utilization of Heilongjiang Province, PR China. Electronic address: .; Pokaż więcej
Źródło:: International journal of biological macromolecules [Int J Biol Macromol] 2024 Sep; Vol. 276 (Pt 1), pp. 133892. Date of Electronic Publication: 2024 Jul 15.
Typ publikacji:: Journal Article
MeSH Terms:: 4-Hydroxyphenylpyruvate Dioxygenase*/antagonists & inhibitors
4-Hydroxyphenylpyruvate Dioxygenase*/chemistry
4-Hydroxyphenylpyruvate Dioxygenase*/metabolism
Molecular Docking Simulation*
Enzyme Inhibitors*/chemistry
Enzyme Inhibitors*/pharmacology
Herbicides/chemistry ; Herbicides/pharmacology ; Molecular Dynamics Simulation ; Oxidoreductases/antagonists & inhibitors ; Oxidoreductases/metabolism ; Oxidoreductases/chemistry ; Drug Evaluation, Preclinical

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Tytuł:: SLCO1B1 and ABCG2 genotype-informed phenotypes are related to variation in ramipril exposure.
Autorzy:: Abbes H; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.; Biochemistry Department, LR12SP11, Sahloul University Hospital, Sousse, Tunisia.; Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia.
Zubiaur P; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.
Soria-Chacartegui P; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.
de la Torre T; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.
Villapalos-García G; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.
Candau C; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.
Rodríguez-Lopez A; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.
González-Iglesias E; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.
Aldama M; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.
Navares-Gomez M; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.
Omezzine A; Biochemistry Department, LR12SP11, Sahloul University Hospital, Sousse, Tunisia.; Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia.
Ochoa D; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.
Abad-Santos F; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.; Pokaż więcej
Źródło:: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2024 Sep; Vol. 135 (3), pp. 295-307. Date of Electronic Publication: 2024 Jul 16.
Typ publikacji:: Journal Article; Randomized Controlled Trial
MeSH Terms:: ATP Binding Cassette Transporter, Subfamily G, Member 2*/genetics
ATP Binding Cassette Transporter, Subfamily G, Member 2*/metabolism
Ramipril*/pharmacokinetics
Ramipril*/administration & dosage
Liver-Specific Organic Anion Transporter 1*/genetics
Phenotype*
Angiotensin-Converting Enzyme Inhibitors*/pharmacokinetics
Angiotensin-Converting Enzyme Inhibitors*/adverse effects
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
Genotype*
Humans ; Male ; Adult ; Young Adult ; Female ; Healthy Volunteers ; Area Under Curve ; Pharmacogenomic Variants ; Pharmacogenetics

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