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Wyszukujesz frazę ""Eosinophils"" wg kryterium: Temat


Tytuł :
Eosinophils improve cardiac function after myocardial infarction.
Autorzy :
Liu J; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.; Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yang C; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Liu T; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.; Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Deng Z; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Fang W; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Zhang X; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Li J; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Huang Q; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Liu C; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Wang Y; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Yang D; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Sukhova GK; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Lindholt JS; Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Odense, Denmark.; Elitary Research Centre of personalised medicine in arterial disease (CIMA), Odense University Hospital, Odense, Denmark.; Cardiovascular Research Unit, Viborg Hospital, Viborg, Denmark.
Diederichsen A; Elitary Research Centre of personalised medicine in arterial disease (CIMA), Odense University Hospital, Odense, Denmark.; Department of Cardiology, Odense University Hospital, Odense, Denmark.
Rasmussen LM; Elitary Research Centre of personalised medicine in arterial disease (CIMA), Odense University Hospital, Odense, Denmark.; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
Li D; Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Newton G; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Luscinskas FW; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Liu L; Department of Biochemistry and Cancer Biology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, 43614, USA.
Libby P; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Wang J; State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing, 100005, China. .
Guo J; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. .; Key Laboratory of Emergency and Trauma of Ministry of Education & Research Unit of Island Emergency Medicine, Chinese Academy of Medical Sciences, Hainan Provincial Key Laboratory for Tropical Cardiovascular Diseases Research, The First Affiliated Hospital, Hainan Medical University, Haikou, 571199, China. .
Shi GP; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 16; Vol. 11 (1), pp. 6396. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Eosinophils/*physiology
Myocardial Infarction/*physiopathology
Myocytes, Cardiac/*pathology
Aged ; Animals ; Cell Death ; Diphtheria Toxin/toxicity ; Electrocardiography ; Eosinophils/drug effects ; Eosinophils/pathology ; Female ; Fibroblasts/pathology ; Fibroblasts/physiology ; Humans ; Interleukin-4/genetics ; Interleukin-4/metabolism ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; Myocardium/pathology ; Ribonucleases/genetics ; Ribonucleases/metabolism
Czasopismo naukowe
Tytuł :
Airways exposure of bacterial superantigen SEB enhances bone marrow eosinophil population and facilitates its egress to blood and lung tissue.
Autorzy :
Pinheiro-Torres AS; Department of Biology and Physiology, Faculty of Medicine of Jundiai (FMJ), Jundiai, São Paulo, Brazil.
Ferreira-Duarte AP; Department of Biology and Physiology, Faculty of Medicine of Jundiai (FMJ), Jundiai, São Paulo, Brazil.
Takeshita WM; Department of Biology and Physiology, Faculty of Medicine of Jundiai (FMJ), Jundiai, São Paulo, Brazil.
Gushiken VO; Department of Biology and Physiology, Faculty of Medicine of Jundiai (FMJ), Jundiai, São Paulo, Brazil.
Roncalho-Buck IA; Department of Biology and Physiology, Faculty of Medicine of Jundiai (FMJ), Jundiai, São Paulo, Brazil.
Anhê GF; Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Antunes E; Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.
DeSouza IA; Department of Biology and Physiology, Faculty of Medicine of Jundiai (FMJ), Jundiai, São Paulo, Brazil. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118685. Date of Electronic Publication: 2020 Nov 01.
Typ publikacji :
Journal Article
MeSH Terms :
Administration, Intranasal/*methods
Bone Marrow/*metabolism
Enterotoxins/*metabolism
Eosinophils/*metabolism
Lung/*metabolism
Nasal Absorption/*physiology
Animals ; Bone Marrow/microbiology ; Bronchoalveolar Lavage Fluid/microbiology ; Enterotoxins/administration & dosage ; Enterotoxins/blood ; Eosinophils/microbiology ; Lung/microbiology ; Male ; Mice ; Mice, Inbred BALB C ; Staphylococcus aureus/metabolism
Czasopismo naukowe
Tytuł :
The Role of Eosinophils during the Withdrawal of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease.
Autorzy :
Wang CY; Cardinal Tien Hospital New Taipei City, Taiwan and.
Lai CC; Kaohsiung Veterans General Hospital Tainan, Taiwan.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2021 Jan 01; Vol. 203 (1), pp. 144-145.
Typ publikacji :
Letter; Comment
MeSH Terms :
Eosinophils*
Pulmonary Disease, Chronic Obstructive*/drug therapy
Adrenal Cortex Hormones ; Double-Blind Method ; Humans
Opinia redakcyjna
Tytuł :
Reply to Wang and Lai: The Role of Eosinophils during the Withdrawal of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease.
Autorzy :
Han MK; University of Michigan Ann Arbor, Michigan.
Lipson DA; GlaxoSmithKline Collegeville, Pennsylvania.; University of Pennsylvania Philadelphia, Pennsylvania.
Singh D; The University of Manchester Manchester, United Kingdom and.
Martinez FJ; New York-Presbyterian Hospital/Weill Cornell Medical Center New York, New York.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2021 Jan 01; Vol. 203 (1), pp. 145-148.
Typ publikacji :
Letter; Comment
MeSH Terms :
Eosinophils*
Pulmonary Disease, Chronic Obstructive*/drug therapy
Adrenal Cortex Hormones ; Double-Blind Method ; Humans
Opinia redakcyjna
Tytuł :
Reply to Lipworth et al. : Don't Forget about Facilitatory Effects of Corticosteroids on β 2 -Adrenoceptors in Acute Asthma.
Autorzy :
Moran AM; University of Oxford Oxfordshire, United Kingdom.
Ramakrishnan S; University of Oxford Oxfordshire, United Kingdom.; Edith Cowan University Perth, Western Australia, Australia.
Borg CA; University of Oxford Oxfordshire, United Kingdom.
Connolly CM; University of Oxford Oxfordshire, United Kingdom.
Couillard S; University of Oxford Oxfordshire, United Kingdom.; Santé de l'Université de Sherbrooke Sherbrooke, Quebec, Canada and.
Mwasuku CM; University of Oxford Oxfordshire, United Kingdom.
Pavord ID; University of Oxford Oxfordshire, United Kingdom.
Hinks TSC; University of Oxford Oxfordshire, United Kingdom.
Lehtimӓki L; University of Oxford Oxfordshire, United Kingdom.; Tampere University Hospital Tampere, Finland.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2020 Dec 15; Vol. 202 (12), pp. 1743-1744.
Typ publikacji :
Letter; Comment
MeSH Terms :
Asthma*/drug therapy
Eosinophils*
Adrenal Cortex Hormones/therapeutic use ; Antibodies, Monoclonal, Humanized ; Humans ; Prednisolone
Opinia redakcyjna
Tytuł :
Don't Forget about Facilitatory Effects of Corticosteroids on β 2 -Adrenoceptors in Acute Asthma.
Autorzy :
Lipworth B; University of Dundee Scotland, United Kingdom.
Chan R; University of Dundee Scotland, United Kingdom.
Kuo CR; University of Dundee Scotland, United Kingdom.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2020 Dec 15; Vol. 202 (12), pp. 1743.
Typ publikacji :
Letter; Comment
MeSH Terms :
Asthma*/drug therapy
Eosinophils*
Adrenal Cortex Hormones/therapeutic use ; Antibodies, Monoclonal, Humanized ; Humans ; Prednisolone
Opinia redakcyjna
Tytuł :
Role of eosinophilic chronic rhinosinusitis in switching to benralizumab treatment in mepolizumab responders.
Autorzy :
Hamada S
Kobayashi Y
Yasuba H
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Źródło :
International journal of clinical pharmacology and therapeutics [Int J Clin Pharmacol Ther] 2020 Dec; Vol. 58 (12), pp. 703-708.
Typ publikacji :
Journal Article
MeSH Terms :
Eosinophils*
Anti-Asthmatic Agents/therapeutic use ; Antibodies, Monoclonal, Humanized ; Asthma/diagnosis ; Asthma/drug therapy ; Chronic Disease ; Humans ; Sinusitis
Czasopismo naukowe
Tytuł :
Induction of ferroptosis-like cell death of eosinophils exerts synergistic effects with glucocorticoids in allergic airway inflammation.
Autorzy :
Wu Y; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Chen H; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Xuan N; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Zhou L; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Wu Y; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Zhu C; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Li M; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Weng Q; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Shen J; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Zhang H; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Zhang B; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Lan F; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Xia L; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Xiong X; Department of Respiratory Medicine, Central Hospital of Lishui City, Lishui, Zhejiang, China.
Li Z; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Zhao Y; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Wu M; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Ying S; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China.
Li W; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China .
Shen H; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China .; State Key Lab for Respiratory Diseases, National Clinical Research Centre for Respiratory Disease, Guangzhou, Guangdong, China.
Chen Z; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, China .
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Źródło :
Thorax [Thorax] 2020 Nov; Vol. 75 (11), pp. 918-927. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ferroptosis*
Bronchial Hyperreactivity/*drug therapy
Eosinophils/*cytology
Animals ; Artesunate/pharmacology ; Benzylamines/pharmacology ; Bronchial Hyperreactivity/pathology ; Bronchoalveolar Lavage Fluid/cytology ; Dexamethasone/pharmacology ; Drug Synergism ; Eosinophils/pathology ; Glucocorticoids/pharmacology ; Humans ; Imidazoles/pharmacology ; Indoles/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Piperazines/pharmacology ; Quinazolines/pharmacology
Czasopismo naukowe
Tytuł :
Eosinopenia could be a relevant prognostic biomarker in patients with coronavirus disease 2019.
Autorzy :
Perlini S; Department of Internal Medicine, Emergency Medicine Unit and Emergency Medicine Postgraduate Training Program, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy.
Ciprandi G; Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.
Castagnoli R; Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Licari A; Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Marseglia GL; Pediatric Clinic, Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
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Źródło :
Allergy and asthma proceedings [Allergy Asthma Proc] 2020 Nov 01; Vol. 41 (6), pp. e80-e82.
Typ publikacji :
Letter
MeSH Terms :
Betacoronavirus*
Eosinophils*
Leukocyte Count*
Coronavirus Infections/*blood
Coronavirus Infections/*diagnosis
Pneumonia, Viral/*blood
Pneumonia, Viral/*diagnosis
Aged ; Aged, 80 and over ; Biomarkers/blood ; COVID-19 ; Coronavirus Infections/mortality ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/mortality ; Predictive Value of Tests ; Prognosis ; Reproducibility of Results ; SARS-CoV-2
Opinia redakcyjna
Tytuł :
A new dawn for eosinophils in the tumour microenvironment.
Autorzy :
Grisaru-Tal S; Department of Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.
Itan M; Department of Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.
Klion AD; Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Munitz A; Department of Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel. .
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Źródło :
Nature reviews. Cancer [Nat Rev Cancer] 2020 Oct; Vol. 20 (10), pp. 594-607. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Tumor Microenvironment*/genetics
Tumor Microenvironment*/immunology
Eosinophils/*pathology
Neoplasms/*pathology
Animals ; Biomarkers ; Chemotaxis, Leukocyte/genetics ; Chemotaxis, Leukocyte/immunology ; Combined Modality Therapy ; Disease Management ; Disease Susceptibility ; Eosinophils/immunology ; Eosinophils/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasms/etiology ; Neoplasms/metabolism ; Neoplasms/therapy ; Signal Transduction
Czasopismo naukowe
Tytuł :
A FACS-based approach to obtain viable eosinophils from human adipose tissue.
Autorzy :
Hernandez JD; Division of Endocrinology, Diabetes and Metabolism, College of Medicine, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USA.
Tew BY; Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Li T; Division of Endocrinology, Diabetes and Metabolism, College of Medicine, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USA.
Gooden GC 2nd; Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ghannam H; Division of Endocrinology, Diabetes and Metabolism, College of Medicine, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USA.
Masuda M; Division of Endocrinology, Diabetes and Metabolism, College of Medicine, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USA.
Madura J 2nd; Division of General Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA.
Salhia B; Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jacobsen EA; Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
De Filippis E; Division of Endocrinology, Diabetes and Metabolism, College of Medicine, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Aug 06; Vol. 10 (1), pp. 13210. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Eosinophils*/chemistry
Eosinophils*/metabolism
Adipose Tissue/*cytology
Flow Cytometry/*methods
Antigens, CD/analysis ; Antigens, Differentiation, B-Lymphocyte/analysis ; Calcium-Binding Proteins/analysis ; Cell Adhesion Molecules/analysis ; DNA Methylation ; GPI-Linked Proteins/analysis ; Humans ; Lectins/analysis ; Mast Cells/chemistry ; Receptors, G-Protein-Coupled/analysis ; Staining and Labeling ; Sulfites ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age.
Autorzy :
Brigger D; Department of Rheumatology, Immunology and Allergology, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Riether C; Tumor Immunology, Department for BioMedical Reserach, University of Bern, Bern, Switzerland.; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
van Brummelen R; Department of Rheumatology, Immunology and Allergology, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Mosher KI; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Department of Chemical and Biological Engineering, University of California, Berkeley, CA, USA.
Shiu A; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Amplitude Analytics Inc., San Francisco, CA, USA.
Ding Z; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Johnson & Johnson Pharmaceutical Research & Development, L.L.C., San Diego, CA, USA.
Zbären N; Department of Rheumatology, Immunology and Allergology, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Gasser P; Department of Rheumatology, Immunology and Allergology, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Guntern P; Department of Rheumatology, Immunology and Allergology, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Yousef H; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Castellano JM; Nash Family Department of Neuroscience, Department of Neurology, Friedman Brain Institute, Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Storni F; Department of Rheumatology, Immunology and Allergology, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.; Department for Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland.
Graff-Radford N; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Britschgi M; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Roche Pharma Research and Early Development, Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Grandgirard D; Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Hinterbrandner M; Tumor Immunology, Department for BioMedical Reserach, University of Bern, Bern, Switzerland.; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Siegrist M; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Moullan N; Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Hofstetter W; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Leib SL; Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Villiger PM; Department of Rheumatology, Immunology and Allergology, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Auwerx J; Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Villeda SA; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.
Wyss-Coray T; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Noti M; Institute of Pathology, Division of Experimental Pathology, University of Bern, Bern, Switzerland. .; Department of Gastrointestinal Health, Immunology, Nestlé Research, Lausanne, Switzerland. .
Eggel A; Department of Rheumatology, Immunology and Allergology, Bern University Hospital, University of Bern, Bern, Switzerland. .; Department for BioMedical Research, University of Bern, Bern, Switzerland. .
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Źródło :
Nature metabolism [Nat Metab] 2020 Aug; Vol. 2 (8), pp. 688-702. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Immunity*
Adipose Tissue/*physiology
Eosinophils/*physiology
Inflammation/*pathology
Physical Fitness/*physiology
Adipose Tissue/pathology ; Adipose Tissue, White/pathology ; Adipose Tissue, White/physiology ; Adult ; Aged ; Aging ; Animals ; Eosinophils/immunology ; Eosinophils/pathology ; Gene Expression Regulation ; Glucose Tolerance Test ; Homeostasis ; Humans ; Interleukin-4/immunology ; Interleukin-4/physiology ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Muscle Strength ; Satellite Cells, Skeletal Muscle/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Anti-Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis.
Autorzy :
Dellon ES; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Peterson KA; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Murray JA; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Falk GW; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Gonsalves N; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Chehade M; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Genta RM; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Leung J; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Khoury P; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Klion AD; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Hazan S; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Vaezi M; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Bledsoe AC; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Durrani SR; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Wang C; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Shaw C; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Chang AT; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Singh B; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Kamboj AP; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Rasmussen HS; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Rothenberg ME; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
Hirano I; From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).
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Źródło :
The New England journal of medicine [N Engl J Med] 2020 Oct 22; Vol. 383 (17), pp. 1624-1634.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Intramural
MeSH Terms :
Eosinophils*
Antibodies, Monoclonal, Humanized/*administration & dosage
Duodenitis/*drug therapy
Enteritis/*drug therapy
Eosinophilia/*drug therapy
Gastritis/*drug therapy
Lectins/*antagonists & inhibitors
Adolescent ; Adult ; Aged ; Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/pharmacology ; Antigens, CD/immunology ; Antigens, Differentiation, B-Lymphocyte/immunology ; Dose-Response Relationship, Drug ; Double-Blind Method ; Duodenitis/complications ; Enteritis/complications ; Eosinophilia/complications ; Female ; Gastritis/complications ; Gastrointestinal Tract/immunology ; Humans ; Infusions, Intravenous/adverse effects ; Lectins/immunology ; Leukocyte Count ; Male ; Middle Aged ; Young Adult
SCR Disease Name :
Eosinophilic enteropathy
Czasopismo naukowe
Tytuł :
Evidence for Exacerbation-Prone Asthma and Predictive Biomarkers of Exacerbation Frequency.
Autorzy :
Peters MC; Division of Pulmonary and Critical Care Medicine, Department of Medicine, and.
Mauger D; Division of Statistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University, Hershey, Pennsylvania.
Ross KR; University Hospitals Rainbow Babies and Children's Hospital/Case Western Reserve University School of Medicine, Cleveland, Ohio.
Phillips B; Division of Statistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University, Hershey, Pennsylvania.
Gaston B; University Hospitals Rainbow Babies and Children's Hospital/Case Western Reserve University School of Medicine, Cleveland, Ohio.
Cardet JC; Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida.
Israel E; Division of Allergy and Immunology Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Levy BD; Division of Allergy and Immunology Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Phipatanakul W; Division of Allergy and Immunology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Jarjour NN; Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine, Madison, Wisconsin.
Castro M; Division of Pulmonary, Critical Care, and Sleep Medicine, University of Kansas School of Medicine, Kansas City, Kansas.
Wenzel SE; Department of Environmental and Occupational Health, Graduate School of Public Health University of Pittsburgh, Pittsburgh, Pennsylvania.; Pulmonary, Allergy and Critical Care Medicine Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Hastie A; Section on Pulmonary, Critical Care, Allergy & Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, North Carolina; and.
Moore W; Section on Pulmonary, Critical Care, Allergy & Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, North Carolina; and.
Bleecker E; Asthma and Airway Disease Research Center and Division of Genetics, Genomics and Precision Medicine, Department of Medicine, The University of Arizona Health Sciences, Tucson, Arizona.
Fahy JV; Division of Pulmonary and Critical Care Medicine, Department of Medicine, and.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, California.
Denlinger LC; Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine, Madison, Wisconsin.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2020 Oct 01; Vol. 202 (7), pp. 973-982.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Eosinophils*
Asthma/*blood
Interleukin-6/*blood
Adult ; Asthma/epidemiology ; Asthma/physiopathology ; Biomarkers ; Comorbidity ; Diabetes Mellitus/epidemiology ; Female ; Forced Expiratory Volume ; Humans ; Hypertension/epidemiology ; Inflammation/blood ; Leukocyte Count ; Male ; Middle Aged ; Obesity/epidemiology ; Phenotype ; Symptom Flare Up
Czasopismo naukowe
Tytuł :
Inhaled aerosolized nicotine suppresses the lung eosinophilic response to house dust mite allergen.
Autorzy :
Gahring LC; Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah.; Division of Geriatrics, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah.
Myers EJ; Division of Geriatrics, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah.
Rogers SW; Geriatric Research, Education, and Clinical Center, Salt Lake City Veterans Administration Medical Center, Salt Lake City, Utah.; Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2020 Oct 01; Vol. 319 (4), pp. L683-L692. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antigens, Dermatophagoides/*drug effects
Eosinophils/*drug effects
Lung/*drug effects
Nicotine/*pharmacology
Animals ; Bronchoalveolar Lavage Fluid/cytology ; Eosinophils/metabolism ; Hypersensitivity/drug therapy ; Hypersensitivity/metabolism ; Lung/metabolism ; Mice ; Mites ; Nicotine/metabolism ; Pyroglyphidae/drug effects ; Pyroglyphidae/immunology
Czasopismo naukowe
Tytuł :
The underlying changes and predicting role of peripheral blood inflammatory cells in severe COVID-19 patients: A sentinel?
Autorzy :
Sun DW; Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin, China. Electronic address: .
Zhang D; Department of Intensive Care Unit, The First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin, China. Electronic address: .
Tian RH; Department of Psychology, The First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin, China. Electronic address: .
Li Y; Department of Thoracic Surgery, The First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin, China. Electronic address: .
Wang YS; Department of Cardiology, The First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin, China.
Cao J; Department of Neurology, The First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin, China. Electronic address: .
Tang Y; Department of Respiration, The First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin, China. Electronic address: .
Zhang N; Department of Gastroenterology, The First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin, China. Electronic address: .
Zan T; Department of Intensive Care Unit, The First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin, China. Electronic address: .
Gao L; Department of Neurology, The First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin, China. Electronic address: .
Huang YZ; Department of Neurology, Tongji Hospital Affiliated to Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: .
Cui CL; Department of Anesthesiology, The First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin, China. Electronic address: .
Wang DX; Department of Ultrasound, The First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin, China. Electronic address: .
Zheng Y; Department of Cardiology, The First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin, China. Electronic address: .
Lv GY; Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Jilin University, Changchun 130021, Jilin, China. Electronic address: .
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Źródło :
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2020 Sep; Vol. 508, pp. 122-129. Date of Electronic Publication: 2020 May 14.
Typ publikacji :
Journal Article
MeSH Terms :
Betacoronavirus/*pathogenicity
Coronavirus Infections/*diagnosis
Eosinophils/*pathology
Lymphocyte Subsets/*pathology
Lymphopenia/*diagnosis
Pneumonia, Viral/*diagnosis
Aged ; Biomarkers/blood ; COVID-19 ; Cell Count ; Coronavirus Infections/blood ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Disease Progression ; Eosinophils/virology ; Female ; Humans ; Killer Cells, Natural/pathology ; Killer Cells, Natural/virology ; Lymphocyte Subsets/virology ; Lymphopenia/blood ; Lymphopenia/physiopathology ; Lymphopenia/virology ; Male ; Middle Aged ; Monocytes/pathology ; Monocytes/virology ; Neutrophils/pathology ; Neutrophils/virology ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; Prognosis ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index ; Survival Analysis
Czasopismo naukowe
Tytuł :
Eosinophilic panniculitis triggered by arthropod bites in chronic lymphocytic leukemia.
Autorzy :
Sernicola A; Unit of Dermatology, Department of Internal and Specialized Medicine, 'Sapienza' University of Rome, Rome, Italy.
Faina V; Unit of Dermatology, Department of Internal and Specialized Medicine, 'Sapienza' University of Rome, Rome, Italy.
Chello C; Unit of Dermatology, Department of Internal and Specialized Medicine, 'Sapienza' University of Rome, Rome, Italy.
Di Fraia M; Unit of Dermatology, Department of Internal and Specialized Medicine, 'Sapienza' University of Rome, Rome, Italy.
Gagliostro N; Unit of Dermatology, Department of Internal and Specialized Medicine, 'Sapienza' University of Rome, Rome, Italy.
Muharremi R; Unit of Dermatology, Department of Internal and Specialized Medicine, 'Sapienza' University of Rome, Rome, Italy.
Magri F; Unit of Dermatology, Department of Internal and Specialized Medicine, 'Sapienza' University of Rome, Rome, Italy.
Grieco T; Unit of Dermatology, Department of Internal and Specialized Medicine, 'Sapienza' University of Rome, Rome, Italy.
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Źródło :
La Clinica terapeutica [Clin Ter] 2020 Sep-Oct; Vol. 171 (5), pp. e369-e370.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Eosinophils*
Insect Bites and Stings/*complications
Leukemia, Lymphocytic, Chronic, B-Cell/*complications
Panniculitis/*etiology
Aged ; Animals ; Female ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Panniculitis/complications
Czasopismo naukowe
Tytuł :
Association between COPD exacerbations and lung function decline during maintenance therapy.
Autorzy :
Kerkhof M; Observational and Pragmatic Research Institute, Singapore.
Voorham J; Observational and Pragmatic Research Institute, Singapore.
Dorinsky P; AstraZeneca, Durham, North Carolina, USA.
Cabrera C; AstraZeneca, Gothenburg, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Darken P; AstraZeneca, 280 Headquarters Plaza, East Tower, Morristown, NJ 07960, USA.
Kocks JW; Observational and Pragmatic Research Institute, Singapore.; General Practitioners Research Institute, Groningen, The Netherlands.
Sadatsafavi M; Respiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
Sin DD; Respiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada.
Carter V; Observational and Pragmatic Research Institute, Singapore.
Price DB; Observational and Pragmatic Research Institute, Singapore .; Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
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Źródło :
Thorax [Thorax] 2020 Sep; Vol. 75 (9), pp. 744-753. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Progression*
Eosinophils*
Adrenal Cortex Hormones/*therapeutic use
Pulmonary Disease, Chronic Obstructive/*drug therapy
Pulmonary Disease, Chronic Obstructive/*physiopathology
Administration, Inhalation ; Adrenal Cortex Hormones/administration & dosage ; Aged ; Female ; Follow-Up Studies ; Forced Expiratory Volume ; Humans ; Leukocyte Count ; Maintenance Chemotherapy ; Male ; Medication Adherence ; Middle Aged ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/blood ; Risk Factors
Czasopismo naukowe
Tytuł :
Surface expression of MRGPRX2 on resting basophils: An area of controversy.
Autorzy :
Sabato V; Department of Immunology, Allergology, Rheumatology, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.; Immunology, Allergology, Rheumatology, Antwerp University Hospital, Antwerp, Belgium.
Elst J; Department of Immunology, Allergology, Rheumatology, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.; Immunology, Allergology, Rheumatology, Antwerp University Hospital, Antwerp, Belgium.
Van Houdt M; Department of Immunology, Allergology, Rheumatology, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.; Immunology, Allergology, Rheumatology, Antwerp University Hospital, Antwerp, Belgium.
Bridts C; Department of Immunology, Allergology, Rheumatology, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.; Immunology, Allergology, Rheumatology, Antwerp University Hospital, Antwerp, Belgium.
Mertens C; Department of Immunology, Allergology, Rheumatology, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.; Immunology, Allergology, Rheumatology, Antwerp University Hospital, Antwerp, Belgium.
Ebo DG; Department of Immunology, Allergology, Rheumatology, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.; Immunology, Allergology, Rheumatology, Antwerp University Hospital, Antwerp, Belgium.
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Źródło :
Allergy [Allergy] 2020 Sep; Vol. 75 (9), pp. 2421-2422.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Basophils*
Eosinophils*
Cell Degranulation ; Receptors, Neuropeptide
Raport
Tytuł :
Eosinophil diversity in asthma.
Autorzy :
Van Hulst G; Laboratory of Cellular and Molecular Immunology, GIGA Institute, Liège University, Liège, Belgium; Faculty of Medicine, Liège University, Liège, Belgium.
Batugedara HM; Laboratory of Cellular and Molecular Immunology, GIGA Institute, Liège University, Liège, Belgium.
Jorssen J; Laboratory of Cellular and Molecular Immunology, GIGA Institute, Liège University, Liège, Belgium; Faculty of Medicine, Liège University, Liège, Belgium.
Louis R; Laboratory of Pneumology, GIGA Institute, Liège University, Liège, Belgium; Department of Pulmonary Medicine, Centre Hospitalier Universitaire, Liège, Belgium.
Bureau F; Laboratory of Cellular and Molecular Immunology, GIGA Institute, Liège University, Liège, Belgium; Faculty of Veterinary Medicine, Liège University, Liège, Belgium; Walloon Excellence in Lifesciences and Biotechnology (WELBIO), Wavres, Belgium.
Desmet CJ; Laboratory of Cellular and Molecular Immunology, GIGA Institute, Liège University, Liège, Belgium; Faculty of Veterinary Medicine, Liège University, Liège, Belgium. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Sep; Vol. 179, pp. 113963. Date of Electronic Publication: 2020 Apr 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Asthma/*pathology
Eosinophils/*pathology
Lung/*cytology
Animals ; Asthma/blood ; Disease Models, Animal ; Eosinophils/metabolism ; Humans
Czasopismo naukowe

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