Temat: "Epigenesis, Genetic" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Enzymatic TET-1 inhibition highlights different epigenetic behaviours of IL-1β and TNFα in tumour progression of OS cell lines.
Autorzy:: Bellavia D; SC Scienze E Tecnologie Chirurgiche - SS Piattaforma Scienze Omiche Per Ortopedia Personalizzata, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Caruccio S; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), Section of Cellular Biology, University of Palermo, Palermo, Italy.
Caradonna F; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), Section of Cellular Biology, University of Palermo, Palermo, Italy.; NBFC, National Biodiversity Future Center, 90133, Palermo, Italy.
Costa V; SC Scienze E Tecnologie Chirurgiche - SS Piattaforma Scienze Omiche Per Ortopedia Personalizzata, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. .
Urzì O; Anna Children's Cancer Research Institute (CCRI), Vienna, Austria.
Raimondi L; SC Scienze E Tecnologie Chirurgiche - SS Piattaforma Scienze Omiche Per Ortopedia Personalizzata, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
De Luca A; SC Scienze E Tecnologie Chirurgiche - SS Piattaforma Scienze Omiche Per Ortopedia Personalizzata, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Pagani S; SC Scienze E Tecnologie Chirurgiche - SS Piattaforma Scienze Omiche Per Ortopedia Personalizzata, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Naselli F; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), Section of Cellular Biology, University of Palermo, Palermo, Italy.
Giavaresi G; SC Scienze E Tecnologie Chirurgiche - SS Piattaforma Scienze Omiche Per Ortopedia Personalizzata, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.; Pokaż więcej
Źródło:: Clinical epigenetics [Clin Epigenetics] 2024 Oct 02; Vol. 16 (1), pp. 136. Date of Electronic Publication: 2024 Oct 02.
Typ publikacji:: Journal Article
MeSH Terms:: Interleukin-1beta*/genetics
Interleukin-1beta*/pharmacology
Epigenesis, Genetic*/drug effects
Epigenesis, Genetic*/genetics
Tumor Necrosis Factor-alpha*/genetics
Tumor Necrosis Factor-alpha*/pharmacology
DNA Methylation*/genetics
DNA Methylation*/drug effects
Proto-Oncogene Proteins*/genetics
Osteosarcoma*/genetics
Osteosarcoma*/drug therapy
Humans ; Cell Line, Tumor ; Disease Progression ; Promoter Regions, Genetic/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Mixed Function Oxygenases/genetics ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Interleukin-6/genetics ; Bone Neoplasms/genetics ; Bone Neoplasms/drug therapy ; Bone Neoplasms/pathology

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Tytuł:: Epigenetic regulation of the oxytocin system as an indicator of adaptation to over-controlling parenting and psychosocial functioning in adulthood.
Autorzy:: Hellwig AF; University of Virginia, USA. Electronic address: .
Wroblewski KL; University of Virginia, USA.
Krol KM; University of Virginia, USA.
Connelly JJ; University of Virginia, USA.
Allen JP; University of Virginia, USA.; Pokaż więcej
Źródło:: Psychoneuroendocrinology [Psychoneuroendocrinology] 2024 Oct; Vol. 168, pp. 107123. Date of Electronic Publication: 2024 Jul 02.
Typ publikacji:: Journal Article
MeSH Terms:: Receptors, Oxytocin*/genetics
Receptors, Oxytocin*/metabolism
Parenting*/psychology
Oxytocin*/metabolism
Oxytocin*/genetics
Epigenesis, Genetic*/genetics
Epigenesis, Genetic*/physiology
DNA Methylation*/physiology
Adaptation, Psychological*/physiology
Humans ; Male ; Female ; Adult ; Adolescent ; Longitudinal Studies ; Young Adult ; Psychosocial Functioning ; Stress, Psychological/genetics ; Stress, Psychological/metabolism ; Stress, Psychological/psychology

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Tytuł:: Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation.
Autorzy:: Zhang T; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Pan Z; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Gao J; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Wu Q; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China.
Bai G; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Li Y; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Tong L; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Feng F; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Lai M; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Liu Y; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Song P; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China.
Ning Y; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Tang H; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Luo W; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China.; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Chen Y; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Fang Y; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhang H; Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liu Q; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; Department of Chemical and Environmental Engineering, University of Nottingham, Ningbo, China.
Zhang Y; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Wang H; University of Chinese Academy of Sciences, Beijing, China.; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.
Chen Z; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Chen Y; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Geng M; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.
Ji H; University of Chinese Academy of Sciences, Beijing, China.; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.
Zhao G; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. .; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China. .; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China. .
Zhou H; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. .; University of Chinese Academy of Sciences, Beijing, China. .
Ding J; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. .; University of Chinese Academy of Sciences, Beijing, China. .
Xie H; Division of Antitumor Pharmacology & Analytical Research Center for Organic and Biological Molecules & State Key Laboratory of Drug Research & Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. .; University of Chinese Academy of Sciences, Beijing, China. .; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China. .; Pokaż więcej
Źródło:: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2024 Aug 15; Vol. 9 (1), pp. 216. Date of Electronic Publication: 2024 Aug 15.
Typ publikacji:: Journal Article
MeSH Terms:: ErbB Receptors*/genetics
ErbB Receptors*/metabolism
Drug Resistance, Neoplasm*/genetics
Drug Resistance, Neoplasm*/drug effects
Transaminases*/genetics
Transaminases*/metabolism
Protein Kinase Inhibitors*/pharmacology
Glycolysis*/drug effects
Glycolysis*/genetics
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/pathology
Carcinoma, Non-Small-Cell Lung*/metabolism
Epigenesis, Genetic*/drug effects
Epigenesis, Genetic*/genetics
Lung Neoplasms*/genetics
Lung Neoplasms*/drug therapy
Lung Neoplasms*/metabolism
Lung Neoplasms*/pathology
Humans ; Mice ; Acrylamides/pharmacology ; Animals ; Aniline Compounds/pharmacology ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/drug effects ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Indoles ; Pyrimidines

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Tytuł:: Epigenetic Reprogramming Potentiates ICAM1 Antibody Drug Conjugates in Preclinical Models of Melanoma.
Autorzy:: Zhang P; Department of Medical Oncology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, 310022, China.; Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, 310014, China.; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.
Tao C; Department of Radiation Oncology, The Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China.; Key Laboratory of Head and Neck Cancer Translational Research of Zhejiang Province, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China.
Lu Y; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.
Li P; Department of Radiation Oncology, The Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China.; Key Laboratory of Head and Neck Cancer Translational Research of Zhejiang Province, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China.
Wang X; Department of Head and Neck Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China.
Dai Y; MabPlex International, Yantai, Shandong, 264006, China.
Xi Y; Department of Pathology, The Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China.
Shimura T; Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan.
Li X; MabPlex International, Yantai, Shandong, 264006, China.
Fang J; School of Materials Science and Engineering, Tianjin University, Tianjin, 300072, China.
Yang L; Department of Medical Oncology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, 310022, China.; Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, 310014, China.
He D; Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China.
Guo P; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.; Pokaż więcej
Źródło:: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Aug; Vol. 11 (30), pp. e2400203. Date of Electronic Publication: 2024 Jun 14.
Typ publikacji:: Journal Article
MeSH Terms:: Intercellular Adhesion Molecule-1*/genetics
Intercellular Adhesion Molecule-1*/metabolism
Melanoma*/drug therapy
Melanoma*/genetics
Immunoconjugates*/pharmacology
Immunoconjugates*/therapeutic use
Epigenesis, Genetic*/drug effects
Epigenesis, Genetic*/genetics
Decitabine*/pharmacology
Decitabine*/therapeutic use
Disease Models, Animal*
Animals ; Mice ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology ; Cell Line, Tumor ; Humans

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Tytuł:: Lithium response in bipolar disorder: Epigenome-wide DNA methylation signatures and epigenetic aging.
Autorzy:: Zafrilla-López M; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain.
Acosta-Díez M; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain.
Mitjans M; Department of Genetics, Microbiology, and Statistics, Faculty of Biology, University of Barcelona, Barcelona, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), Spain; CIBER de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Spain. Electronic address: .
Giménez-Palomo A; Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.
Saiz PA; Department of Psychiatry, Servicio de Salud del Principado de Asturias (SESPA), School of Medicine, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain; CIBER de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Barrot-Feixat C; Forensic Genetic Laboratory, University of Barcelona, Catalonia, Spain.
Jiménez E; Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; Institut de Neurociències, Department of Medicine, University of Barcelona, Barcelona, Spain; CIBER de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Papiol S; CIBER de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany; Max Planck Institute of Psychiatry, Munich, Germany.
Ruiz V; Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.
Gavín P; Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.
García-Portilla MP; Department of Psychiatry, Servicio de Salud del Principado de Asturias (SESPA), School of Medicine, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain; CIBER de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
González-Blanco L; Department of Psychiatry, Servicio de Salud del Principado de Asturias (SESPA), School of Medicine, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain; CIBER de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Bobes J; Department of Psychiatry, Servicio de Salud del Principado de Asturias (SESPA), School of Medicine, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto de Neurociencias del Principado de Asturias (INEUROPA), Oviedo, Spain; CIBER de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Schulze TG; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Vieta E; Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; Institut de Neurociències, Department of Medicine, University of Barcelona, Barcelona, Spain; CIBER de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Benabarre A; Bipolar and Depressive Disorders Unit, Psychiatry and Psychology Service, Clinical Institute of Neuroscience, Hospital Clinic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; Institut de Neurociències, Department of Medicine, University of Barcelona, Barcelona, Spain; CIBER de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Arias B; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), Spain; CIBER de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.; Pokaż więcej
Źródło:: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2024 Aug; Vol. 85, pp. 23-31. Date of Electronic Publication: 2024 Apr 25.
Typ publikacji:: Journal Article
MeSH Terms:: Bipolar Disorder*/genetics
Bipolar Disorder*/drug therapy
DNA Methylation*/drug effects
Epigenesis, Genetic*/drug effects
Epigenesis, Genetic*/genetics
Aging*/genetics
Humans ; Female ; Male ; Adult ; Middle Aged ; Epigenome/genetics ; Antimanic Agents/therapeutic use ; Lithium Compounds/therapeutic use ; Lithium Compounds/pharmacology

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Tytuł:: Epigenetic molecular underpinnings of brain structural-functional connectivity decoupling in patients with major depressive disorder.
Autorzy:: Tang L; Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, PR China; Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, PR China.
Zhao P; Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, PR China.
Pan C; School of Computer Science and Engineering, Northeastern University, Shenyang, PR China.
Song Y; Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, PR China.
Zheng J; Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, PR China.
Zhu R; Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, PR China.
Wang F; Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, PR China. Electronic address: .
Tang Y; Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China. Electronic address: .; Pokaż więcej
Źródło:: Journal of affective disorders [J Affect Disord] 2024 Oct 15; Vol. 363, pp. 249-257. Date of Electronic Publication: 2024 Jul 17.
Typ publikacji:: Journal Article
MeSH Terms:: Depressive Disorder, Major*/physiopathology
Depressive Disorder, Major*/genetics
Depressive Disorder, Major*/diagnostic imaging
Connectome*
DNA Methylation*
Epigenesis, Genetic*
Brain*/physiopathology
Brain*/diagnostic imaging
Humans ; Female ; Male ; Adult ; Middle Aged ; Tacrolimus Binding Proteins/genetics ; Hypothalamo-Hypophyseal System/physiopathology ; Hypothalamo-Hypophyseal System/metabolism ; Receptors, Corticotropin-Releasing Hormone/genetics ; Magnetic Resonance Imaging ; Pituitary-Adrenal System/physiopathology ; Receptors, Glucocorticoid/genetics ; Case-Control Studies

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Tytuł:: Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy.
Autorzy:: Kang TG; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Lan X; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN 38105, USA.
Mi T; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Chen H; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Alli S; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Lim SE; College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN 38105, USA.; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Bhatara S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Vasandan AB; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Ward G; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Bentivegna S; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.; Biotech Research and Innovation Center (BRIC), University of Copenhagen, DK-2200 Copenhagen, Denmark.
Jang J; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
Spatz ML; Merck & Co. Inc., Rahway, NJ 07065, USA.
Han JH; Merck & Co. Inc., Rahway, NJ 07065, USA.
Schlotmann BC; The Finsen Laboratory, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
Jespersen JS; Biotech Research and Innovation Center (BRIC), University of Copenhagen, DK-2200 Copenhagen, Denmark.
Derenzo C; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Vogel P; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yu J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Baylin S; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Institute at Johns Hopkins, Baltimore, MD 21231, USA.
Jones P; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA.
O'Connell C; Jane Anne Nohl Division of Hematology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Grønbæk K; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.; Biotech Research and Innovation Center (BRIC), University of Copenhagen, DK-2200 Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Youngblood B; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Zebley CC; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2024 Oct 11; Vol. 386 (6718), pp. eadl4492. Date of Electronic Publication: 2024 Oct 11.
Typ publikacji:: Journal Article
MeSH Terms:: CD8-Positive T-Lymphocytes*/immunology
Clonal Hematopoiesis*
Epigenesis, Genetic*
Dioxygenases*
Immunotherapy*
DNA Methyltransferase 3A*
Repressor Proteins*/genetics
Repressor Proteins*/metabolism
DNA-Binding Proteins*/genetics
DNA-Binding Proteins*/metabolism
Proto-Oncogene Proteins*/metabolism
Proto-Oncogene Proteins*/genetics
Animals ; Mice ; Humans ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; Cell Differentiation ; Immune Checkpoint Inhibitors/therapeutic use ; Histones/metabolism ; B7-H1 Antigen/metabolism ; B7-H1 Antigen/genetics

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Tytuł:: Unwrapping stemness to revive T cells.
Autorzy:: Tsui C; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
Kallies A; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2024 Oct 11; Vol. 386 (6718), pp. 148-149. Date of Electronic Publication: 2024 Oct 10.
Typ publikacji:: Journal Article; Comment
MeSH Terms:: Epigenesis, Genetic*
Humans ; Animals ; T-Lymphocytes/immunology ; Mice ; CD8-Positive T-Lymphocytes/immunology

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Tytuł:: Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy.
Autorzy:: Zhang Y; State Key Laboratory of Microbial Metabolism and Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.; Columbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.; Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Karagiannis D; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.
Liu H; Columbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.; Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.; Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, Hainan, China.
Lin M; Columbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.; Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China.
Fang Y; Columbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.; Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Jiang M; Center for Genetic Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310030, Zhejiang, China.
Chen X; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.
Suresh S; Columbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.; Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Huang H; State Key Laboratory of Microbial Metabolism and Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
She J; Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.; Center for Gut Microbiome Research, Med-X Institute, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Shi F; Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.; Center for Gut Microbiome Research, Med-X Institute, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Liu J; State Key Laboratory of Microbial Metabolism and Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Luo D; State Key Laboratory of Microbial Metabolism and Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Angel JC; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.
Lin G; Columbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.; Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China.
Yang P; Department of Internal Medicine, Westchester Medical Center/New York Medical College, Valhalla, NY 10595, USA.
El-Rifai W; Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.; Miami Veterans Affairs Healthcare System, Miami, FL 33136, USA.
Zaika A; Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.; Miami Veterans Affairs Healthcare System, Miami, FL 33136, USA.
Oro AE; Programin Epithelial Biology, Stanford University School of Medicine, Stanford 94305, CA, USA.
Liu K; Central Laboratory, Xiang'an Hospital, School of Medicine, Xiamen University, Xiamen 361102, Fujian, China.
Rustgi AK; Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Wang TC; Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Lu C; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Que J; Columbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.; Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.; Pokaż więcej
Źródło:: Science advances [Sci Adv] 2024 Oct 11; Vol. 10 (41), pp. eadq0479. Date of Electronic Publication: 2024 Oct 09.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Transdifferentiation*/genetics
Esophageal Neoplasms*/genetics
Esophageal Neoplasms*/metabolism
Esophageal Neoplasms*/pathology
Esophagus*/metabolism
Esophagus*/pathology
Epigenesis, Genetic*
Humans ; Animals ; Mice ; Tumor Suppressor Proteins/metabolism ; Tumor Suppressor Proteins/genetics ; Gene Expression Regulation, Neoplastic ; Trans-Activators/metabolism ; Trans-Activators/genetics ; Cell Line, Tumor ; Carcinoma, Neuroendocrine/metabolism ; Carcinoma, Neuroendocrine/genetics ; Carcinoma, Neuroendocrine/pathology ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Enhancer of Zeste Homolog 2 Protein/genetics ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Neuroendocrine Cells/metabolism ; Neuroendocrine Cells/pathology

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Tytuł:: Rewriting cellular fate: epigenetic interventions in obesity and cellular programming.
Autorzy:: Li RL; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Jimo Road 150, Shanghai, 200120, China.
Kang S; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Jimo Road 150, Shanghai, 200120, China. .; Pokaż więcej
Źródło:: Molecular medicine (Cambridge, Mass.) [Mol Med] 2024 Oct 10; Vol. 30 (1), pp. 169. Date of Electronic Publication: 2024 Oct 10.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Epigenesis, Genetic*
Obesity*/genetics
Obesity*/metabolism
Cellular Reprogramming*/genetics
DNA Methylation*
Humans ; Animals ; Cell Differentiation/genetics ; Adipogenesis/genetics ; Histones/metabolism ; Histone Code ; Epigenomics/methods

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Tytuł:: Genome-wide DNA methylation and their transgenerational pattern differ in Arabidopsis thaliana populations originated along the elevation of West Himalaya.
Autorzy:: Singh A; Plant Molecular Biology and Biotechnology Division, CSIR-National Botanical Research Institute, Lucknow, 226001, India.
Verma AK; Plant Molecular Biology and Biotechnology Division, CSIR-National Botanical Research Institute, Lucknow, 226001, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Kumar S; Plant Molecular Biology and Biotechnology Division, CSIR-National Botanical Research Institute, Lucknow, 226001, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Bag SK; Plant Molecular Biology and Biotechnology Division, CSIR-National Botanical Research Institute, Lucknow, 226001, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.; Computational Biology, CSIR-National Botanical Research Institute, Lucknow, 226001, India.
Roy S; Plant Molecular Biology and Biotechnology Division, CSIR-National Botanical Research Institute, Lucknow, 226001, India. .; Department of Plant Sciences, Central University of Hyderabad, Hyderabad, Telangana, India. .; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. .; Pokaż więcej
Źródło:: BMC plant biology [BMC Plant Biol] 2024 Oct 09; Vol. 24 (1), pp. 936. Date of Electronic Publication: 2024 Oct 09.
Typ publikacji:: Journal Article
MeSH Terms:: Arabidopsis*/genetics
DNA Methylation*
Genome, Plant*
Epigenesis, Genetic*
India ; Altitude ; Phenotype ; Gene Expression Regulation, Plant

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Tytuł:: Epigenetic landscape reorganisation and reactivation of embryonic development genes are associated with malignancy in IDH-mutant astrocytoma.
Autorzy:: Ghisai SA; Department of Neurology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
van Hijfte L; Department of Neurology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.; Department of Tumour Immunology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Vallentgoed WR; Department of Neurology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Tesileanu CMS; Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.
de Heer I; Department of Neurology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Kros JM; Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Sanson M; ICM Institute for Brain and Spinal Cords, Sorbonne University, Paris, France.
Gorlia T; EORTC Headquarters, Brussels, Belgium.
Wick W; Neurology Department, University Clinic Heidelberg, Heidelberg University & German Center, Heidelberg, Germany.
Vogelbaum MA; Neuro-Oncology Department, Moffitt Cancer Center, Tampa, FL, USA.
Brandes AA; Nervous System Medical Oncology Department, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
Franceschi E; Nervous System Medical Oncology Department, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
Clement PM; Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.
Nowak AK; Medical School, The University of Western Australia, Crawley, WA, Australia.
Golfinopoulos V; EORTC Headquarters, Brussels, Belgium.
van den Bent MJ; Department of Neurology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
French PJ; Department of Neurology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. .
Hoogstrate Y; Department of Neurology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.; Pokaż więcej
Źródło:: Acta neuropathologica [Acta Neuropathol] 2024 Oct 09; Vol. 148 (1), pp. 50. Date of Electronic Publication: 2024 Oct 09.
Typ publikacji:: Journal Article
MeSH Terms:: Astrocytoma*/genetics
Astrocytoma*/pathology
Isocitrate Dehydrogenase*/genetics
Brain Neoplasms*/genetics
Brain Neoplasms*/pathology
DNA Methylation*/genetics
Mutation*/genetics
Epigenesis, Genetic*/genetics
Humans ; Female ; Male ; Embryonic Development/genetics ; Middle Aged ; Adult ; Neoplasm Grading

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Tytuł:: Epitranscriptomics and cervical cancer: the emerging role of m A RNA modifications.
Autorzy:: Modi AD; Department of Biological Sciences, University of Toronto, Scarborough, Canada.
Zahid H; Department of Biology, University of Toronto, Mississauga, Canada.
Southerland AC; Department of Health Sciences, California State University, Los Angeles, USA.
Modi DM; Department of Pharmacy, Silver Oak University, Ahmedabad, India.; Pokaż więcej
Źródło:: Expert reviews in molecular medicine [Expert Rev Mol Med] 2024 Oct 08; Vol. 26, pp. e20. Date of Electronic Publication: 2024 Oct 08.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Uterine Cervical Neoplasms*/genetics
Uterine Cervical Neoplasms*/pathology
Uterine Cervical Neoplasms*/therapy
Uterine Cervical Neoplasms*/metabolism
Epigenesis, Genetic*
Humans ; Female ; Adenosine/analogs & derivatives ; Adenosine/metabolism ; Gene Expression Regulation, Neoplastic ; Transcriptome ; 5-Methylcytosine/analogs & derivatives ; 5-Methylcytosine/metabolism ; RNA Processing, Post-Transcriptional ; Animals ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism

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Tytuł:: Applicability of epigenetic age models to next-generation methylation arrays.
Autorzy:: Garma LD; Breast Cancer Clinical Research Unit, Centro Nacional de Investigaciones Oncológicas-CNIO, Melchor Fernández Almagro, 3, Madrid, 28029, Spain.
Quintela-Fandino M; Breast Cancer Clinical Research Unit, Centro Nacional de Investigaciones Oncológicas-CNIO, Melchor Fernández Almagro, 3, Madrid, 28029, Spain. .; Pokaż więcej
Źródło:: Genome medicine [Genome Med] 2024 Oct 07; Vol. 16 (1), pp. 116. Date of Electronic Publication: 2024 Oct 07.
Typ publikacji:: Journal Article
MeSH Terms:: DNA Methylation*
Epigenesis, Genetic*
Humans ; Female ; Breast Neoplasms/genetics ; Breast Neoplasms/radiotherapy ; Aging/genetics ; Middle Aged ; CpG Islands ; Adult ; Aged ; Oligonucleotide Array Sequence Analysis ; Male ; Models, Genetic ; Epigenomics/methods

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Tytuł:: EPO modified MSCs protects SH-SY5Y cells against ischemia/hypoxia-induced apoptosis via REST-dependent epigenetic remodeling.
Autorzy:: Jiang Y; Department of Neurosurgery, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, 450000, China.
Li R; Department of Neurosurgery, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, 450000, China.
Ban Y; Department of Neurosurgery, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, 450000, China.
Zhang W; Department of Neurosurgery, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, 450000, China.
Kong N; Department of Neurosurgery, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, 450000, China.
Tang J; Department of Neurosurgery, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, 450000, China.
Ma B; Department of Neurosurgery, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, 450000, China.
Shao Y; Department of Neurosurgery, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, 450000, China.
Jin R; Department of Neurosurgery, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, 450000, China.
Sun L; Department of Neurosurgery, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, 450000, China. .
Yue H; Stem Cell Research Center, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, China. .
Zhang H; Department of Neurosurgery, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, 450000, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Oct 06; Vol. 14 (1), pp. 23252. Date of Electronic Publication: 2024 Oct 06.
Typ publikacji:: Journal Article
MeSH Terms:: Erythropoietin*/metabolism
Erythropoietin*/genetics
Apoptosis*
Mesenchymal Stem Cells*/metabolism
Epigenesis, Genetic*
Humans ; Cell Hypoxia ; Hypoxia-Ischemia, Brain/metabolism ; Hypoxia-Ischemia, Brain/genetics ; Hypoxia-Ischemia, Brain/therapy ; Cell Line, Tumor ; Repressor Proteins/metabolism ; Repressor Proteins/genetics

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Tytuł:: Cell type-specific epigenetic priming of gene expression in nucleus accumbens by cocaine.
Autorzy:: Mews P; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Van der Zee Y; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gurung A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Estill M; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Futamura R; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kronman H; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ramakrishnan A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ryan M; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Reyes AA; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Garcia BA; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.
Browne CJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sidoli S; Department of Biochemistry, Albert Einstein College of Medticine, New York, NY, USA.
Shen L; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nestler EJ; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Pokaż więcej
Źródło:: Science advances [Sci Adv] 2024 Oct 04; Vol. 10 (40), pp. eado3514. Date of Electronic Publication: 2024 Oct 04.
Typ publikacji:: Journal Article
MeSH Terms:: Nucleus Accumbens*/metabolism
Nucleus Accumbens*/drug effects
Cocaine*/pharmacology
Epigenesis, Genetic*/drug effects
Histones*/metabolism
Animals ; Mice ; Male ; Gene Expression Regulation/drug effects ; Cocaine-Related Disorders/genetics ; Cocaine-Related Disorders/metabolism ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D1/genetics ; Neurons/metabolism ; Neurons/drug effects ; Chromatin/metabolism ; Chromatin/genetics

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Tytuł:: Epitranscriptome in action: RNA modifications in the DNA damage response.
Autorzy:: Xhemalçe B; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: .
Miller KM; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: .
Gromak N; Sir William Dunn School of Pathology, University of Oxford, South Parks Road OX1 3RE, UK. Electronic address: .; Pokaż więcej
Źródło:: Molecular cell [Mol Cell] 2024 Oct 03; Vol. 84 (19), pp. 3610-3626.
Typ publikacji:: Journal Article; Review
MeSH Terms:: DNA Damage*
DNA Repair*
RNA*/metabolism
RNA*/genetics
Epigenesis, Genetic*
Humans ; Animals ; Transcriptome ; RNA Processing, Post-Transcriptional ; Genomic Instability ; RNA Editing ; Adenosine/metabolism ; Adenosine/analogs & derivatives ; Adenosine/genetics

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Tytuł:: Inflammation-induced epigenetic imprinting regulates intestinal stem cells.
Autorzy:: Zhao D; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Department of Internal Medicine, Houston, TX 77030, USA.
Ravikumar V; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Leach TJ; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Department of Internal Medicine, Houston, TX 77030, USA.
Kraushaar D; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Department of Internal Medicine, Houston, TX 77030, USA.
Lauder E; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Department of Internal Medicine, Houston, TX 77030, USA; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Rogel Cancer Center, Ann Arbor, MI 48109, USA.
Li L; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Department of Internal Medicine, Houston, TX 77030, USA.
Sun Y; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Department of Internal Medicine, Houston, TX 77030, USA.
Oravecz-Wilson K; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Rogel Cancer Center, Ann Arbor, MI 48109, USA.
Keller ET; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Chen F; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Department of Internal Medicine, Houston, TX 77030, USA.
Maneix L; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Department of Internal Medicine, Houston, TX 77030, USA.
Jenq RR; Department of Genomic Medicine and Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Britton R; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Department of Internal Medicine, Houston, TX 77030, USA.
King KY; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Department of Internal Medicine, Houston, TX 77030, USA.
Santibanez AE; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Department of Internal Medicine, Houston, TX 77030, USA.
Creighton CJ; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Department of Internal Medicine, Houston, TX 77030, USA.
Rao A; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Reddy P; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Department of Internal Medicine, Houston, TX 77030, USA; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Rogel Cancer Center, Ann Arbor, MI 48109, USA. Electronic address: .; Pokaż więcej
Źródło:: Cell stem cell [Cell Stem Cell] 2024 Oct 03; Vol. 31 (10), pp. 1447-1464.e6. Date of Electronic Publication: 2024 Sep 03.
Typ publikacji:: Journal Article
MeSH Terms:: Inflammation*/pathology
Inflammation*/genetics
Epigenesis, Genetic*
Stem Cells*/metabolism
Stem Cells*/cytology
Intestines*/cytology
Animals ; Mice ; Genomic Imprinting ; Mice, Inbred C57BL ; Graft vs Host Disease ; Regeneration ; Cell Differentiation ; Receptors, G-Protein-Coupled/metabolism ; Receptors, G-Protein-Coupled/genetics ; Organoids/metabolism

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Tytuł:: Rethinking the pathogenesis of endometriosis: Complex interactions of genomic, epigenetic, and environmental factors.
Autorzy:: Kobayashi H; Department of Gynecology and Reproductive Medicine, Ms.Clinic MayOne, Kashihara, Japan.; Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan.
Imanaka S; Department of Gynecology and Reproductive Medicine, Ms.Clinic MayOne, Kashihara, Japan.; Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan.
Yoshimoto C; Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan.; Department of Obstetrics and Gynecology, Nara Prefecture General Medical Center, Nara, Japan.
Matsubara S; Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan.; Department of Medicine, Kei Oushin Clinic, Nishinomiya, Japan.
Shigetomi H; Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan.; Department of Gynecology and Reproductive Medicine, Aska Ladies Clinic, Nara, Japan.; Pokaż więcej
Źródło:: The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2024 Oct; Vol. 50 (10), pp. 1771-1784. Date of Electronic Publication: 2024 Sep 18.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Endometriosis*/genetics
Endometriosis*/metabolism
Epigenesis, Genetic*
Humans ; Female ; Gene-Environment Interaction

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Tytuł:: Epigenetic inheritance and gene expression regulation in early Drosophila embryos.
Autorzy:: Ciabrelli F; Max Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg im Breisgau, Germany.
Atinbayeva N; Max Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg im Breisgau, Germany.
Pane A; Institute of Biomedical Sciences/UFRJ, 21941902, Rio de Janeiro, Brazil.
Iovino N; Max Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg im Breisgau, Germany. .; Pokaż więcej
Źródło:: EMBO reports [EMBO Rep] 2024 Oct; Vol. 25 (10), pp. 4131-4152. Date of Electronic Publication: 2024 Sep 16.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Epigenesis, Genetic*
Gene Expression Regulation, Developmental*
Chromatin*/metabolism
Chromatin*/genetics
Animals ; Zygote/metabolism ; Embryonic Development/genetics ; Embryo, Nonmammalian/metabolism ; Drosophila/genetics ; Drosophila/embryology ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism

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