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Wyszukujesz frazę ""Epigenetic"" wg kryterium: Temat


Tytuł :
Inhibition of EZH2 primes the cardiac gene activation via removal of epigenetic repression during human direct cardiac reprogramming.
Autorzy :
Tang Y; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Zhao L; Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Yu X; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Zhang J; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Qian L; Department of Pathology and Laboratory Medicine, McAllister Heart Institute, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Jin J; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Lu R; Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Zhou Y; Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35233, USA. Electronic address: .
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Źródło :
Stem cell research [Stem Cell Res] 2021 May; Vol. 53, pp. 102365. Date of Electronic Publication: 2021 Apr 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Enhancer of Zeste Homolog 2 Protein*/genetics
Enhancer of Zeste Homolog 2 Protein*/metabolism
Epigenetic Repression*
Fibroblasts/metabolism ; Histones/metabolism ; Humans ; Myocytes, Cardiac/metabolism ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution.
Autorzy :
Weber CM; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.
Hafner A; Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.
Kirkland JG; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.; Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Braun SMG; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.; University of Geneva, Department of Genetic Medicine, Geneva, Switzerland.
Stanton BZ; Nationwide Children's Hospital, Center for Childhood Cancer and Blood Diseases, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA.; Department of Biological Chemistry and Pharmacology, The Ohio State University College of Medicine, Columbus, OH, USA.
Boettiger AN; Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.
Crabtree GR; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. .; Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA. .; Howard Hughes Medical Institute, Chevy Chase, MD, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Jun; Vol. 28 (6), pp. 501-511. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin Assembly and Disassembly/*physiology
Epigenetic Repression/*physiology
Gene Expression Regulation/*physiology
Multiprotein Complexes/*physiology
Polycomb-Group Proteins/*physiology
Animals ; CRISPR-Cas Systems ; Cells, Cultured ; Chromatin Assembly and Disassembly/genetics ; DNA Helicases/genetics ; DNA Helicases/metabolism ; DNA-Binding Proteins/physiology ; Embryonic Stem Cells/metabolism ; Epigenesis, Genetic ; Epigenetic Repression/genetics ; Gene Editing ; Gene Expression Regulation/genetics ; Genes, Homeobox ; Genome ; HEK293 Cells ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Loss of Function Mutation ; Mice ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Proteolysis ; Recombinant Fusion Proteins/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription Factors/physiology
Czasopismo naukowe
Tytuł :
Dynamic methylation of histone H3K18 in differentiating Theileria parasites.
Autorzy :
Cheeseman K; Université de Paris, Epigenetics and Cell Fate, CNRS, Paris, France.
Jannot G; Université de Paris, Epigenetics and Cell Fate, CNRS, Paris, France.
Lourenço N; Université de Paris, Epigenetics and Cell Fate, CNRS, Paris, France.
Villares M; Université de Paris, Epigenetics and Cell Fate, CNRS, Paris, France.
Berthelet J; Université de Paris, Epigenetics and Cell Fate, CNRS, Paris, France.; Université de Paris, Functional and Adaptive Biology, CNRS, Paris, France.
Calegari-Silva T; Université de Paris, Epigenetics and Cell Fate, CNRS, Paris, France.
Hamroune J; Université de Paris, Institut Cochin, Inserm, CNRS, Paris, France.
Letourneur F; Université de Paris, Institut Cochin, Inserm, CNRS, Paris, France.
Rodrigues-Lima F; Université de Paris, Functional and Adaptive Biology, CNRS, Paris, France.
Weitzman JB; Université de Paris, Epigenetics and Cell Fate, CNRS, Paris, France. .
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Źródło :
Nature communications [Nat Commun] 2021 May 28; Vol. 12 (1), pp. 3221. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenetic Repression/*physiology
Gene Expression Regulation, Developmental/*physiology
Histones/*metabolism
Life Cycle Stages/*genetics
Theileria/*growth & development
Acetylation/drug effects ; Animals ; Cattle ; Cell Line ; Chickens ; Chromatin Immunoprecipitation Sequencing ; Epigenetic Repression/drug effects ; Gene Expression Regulation, Developmental/drug effects ; HEK293 Cells ; Humans ; Insect Proteins/metabolism ; Life Cycle Stages/drug effects ; Lysine/metabolism ; Methylation/drug effects ; Methyltransferases/genetics ; Methyltransferases/isolation & purification ; Methyltransferases/metabolism ; Mutagenesis, Site-Directed ; Peptides, Cyclic/pharmacology ; Peptides, Cyclic/therapeutic use ; RNA-Seq ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Theileria/genetics ; Theileriasis/drug therapy ; Theileriasis/parasitology ; Tranylcypromine/pharmacology ; Tranylcypromine/therapeutic use
Czasopismo naukowe
Tytuł :
H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions.
Autorzy :
Cai Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
Zhang Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Loh YP; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Tng JQ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Lim MC; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore.
Cao Z; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Raju A; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore.
Lieberman Aiden E; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Li S; Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Manikandan L; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore.
Tergaonkar V; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore.
Tucker-Kellogg G; Department of Biological Sciences, National University of Singapore, Singapore, Singapore. .; Computational Biology Programme, National University of Singapore, Singapore, Singapore. .
Fullwood MJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. .; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore. .; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 29; Vol. 12 (1), pp. 719. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenetic Repression*
Chromatin/*metabolism
Histones/*genetics
Neoplasms/*genetics
Silencer Elements, Transcriptional/*genetics
Animals ; Cell Line, Tumor ; Chromatin/genetics ; Chromatin Immunoprecipitation Sequencing ; Female ; Fibroblast Growth Factors/genetics ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Gene Knockout Techniques ; Histones/metabolism ; Humans ; Insulin-Like Growth Factor II/genetics ; Mice ; RNA-Seq ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
PP1 regulatory subunit NIPP1 regulates transcription of E2F1 target genes following DNA damage.
Autorzy :
Hanaki S; Department of Biochemistry, Joint Faculty of Veterinary Science, Yamaguchi University, Yamaguchi, Japan.
Habara M; Department of Biochemistry, Joint Faculty of Veterinary Science, Yamaguchi University, Yamaguchi, Japan.
Masaki T; Department of Biochemistry, Joint Faculty of Veterinary Science, Yamaguchi University, Yamaguchi, Japan.
Maeda K; Department of Biochemistry, Joint Faculty of Veterinary Science, Yamaguchi University, Yamaguchi, Japan.
Sato Y; Department of Biochemistry, Joint Faculty of Veterinary Science, Yamaguchi University, Yamaguchi, Japan.
Nakanishi M; Division of Cancer Biology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Shimada M; Department of Biochemistry, Joint Faculty of Veterinary Science, Yamaguchi University, Yamaguchi, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Jul; Vol. 112 (7), pp. 2739-2752. Date of Electronic Publication: 2021 May 03.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Damage*
Cyclic AMP-Dependent Protein Kinases/*metabolism
E2F1 Transcription Factor/*genetics
Endoribonucleases/*metabolism
Histones/*metabolism
Phosphoprotein Phosphatases/*metabolism
Protein Phosphatase 1/*metabolism
RNA-Binding Proteins/*metabolism
CRISPR-Cas Systems ; Cell Proliferation ; Cells, Cultured ; Checkpoint Kinase 1/metabolism ; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors ; Endoribonucleases/deficiency ; Endoribonucleases/isolation & purification ; Epigenetic Repression ; Gene Expression Regulation ; Humans ; Phosphoprotein Phosphatases/deficiency ; Phosphoprotein Phosphatases/isolation & purification ; Phosphorylation ; Promoter Regions, Genetic ; Protein Processing, Post-Translational ; RNA, Messenger/metabolism ; RNA-Binding Proteins/isolation & purification ; Receptors, Neuropeptide Y/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Transcription, Genetic ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global epigenetic landscapes.
Autorzy :
Shukla R; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, WGH, University of Edinburgh, Edinburgh EH4 2XU, UK.; Newcastle University Centre for Cancer, Biosciences Institute, Newcastle University, Newcastle-upon-Tyne NE2 4HH, UK.
Mjoseng HK; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, WGH, University of Edinburgh, Edinburgh EH4 2XU, UK.
Thomson JP; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, WGH, University of Edinburgh, Edinburgh EH4 2XU, UK.
Kling S; NMI Natural and Medical Sciences Institute, Tübingen University, Reutlingen, Germany.
Sproul D; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, WGH, University of Edinburgh, Edinburgh EH4 2XU, UK.
Dunican DS; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, WGH, University of Edinburgh, Edinburgh EH4 2XU, UK.
Ramsahoye B; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, WGH, University of Edinburgh, Edinburgh EH4 2XU, UK.
Wongtawan T; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Treindl F; NMI Natural and Medical Sciences Institute, Tübingen University, Reutlingen, Germany.; Pharmaceutical Biotechnology, Tübingen University, Tübingen, Germany.
Templin MF; NMI Natural and Medical Sciences Institute, Tübingen University, Reutlingen, Germany.; Pharmaceutical Biotechnology, Tübingen University, Tübingen, Germany.
Adams IR; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, WGH, University of Edinburgh, Edinburgh EH4 2XU, UK.
Pennings S; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Meehan RR; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, WGH, University of Edinburgh, Edinburgh EH4 2XU, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Aug 20; Vol. 48 (14), pp. 7748-7766.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenetic Repression*
Gene Regulatory Networks*
Mouse Embryonic Stem Cells/*metabolism
Animals ; Cells, Cultured ; DNA Methylation ; Epigenesis, Genetic ; Glycogen Synthase Kinase 3 beta/antagonists & inhibitors ; Histones/metabolism ; Male ; Mice ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors ; Mouse Embryonic Stem Cells/drug effects ; Mouse Embryonic Stem Cells/enzymology ; Transcription Factors/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Analysis of 3297 individuals suggests that the pathogenic germline 5'-UTR variant BRCA1 c.-107A > T is not common in south-east Germany.
Autorzy :
Laner A; MGZ - Medizinisch Genetisches Zentrum, Bayerstr. 3-5, 80035, Munich, Germany. .
Benet-Pages A; MGZ - Medizinisch Genetisches Zentrum, Bayerstr. 3-5, 80035, Munich, Germany. .
Neitzel B; MGZ - Medizinisch Genetisches Zentrum, Bayerstr. 3-5, 80035, Munich, Germany.
Holinski-Feder E; MGZ - Medizinisch Genetisches Zentrum, Bayerstr. 3-5, 80035, Munich, Germany. .
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Źródło :
Familial cancer [Fam Cancer] 2020 Jul; Vol. 19 (3), pp. 211-213. Date of Electronic Publication: 2020 Mar 21.
Typ publikacji :
Journal Article
MeSH Terms :
Epigenetic Repression*
Genes, BRCA1*
Promoter Regions, Genetic*
5' Untranslated Regions/*genetics
Breast Neoplasms/*genetics
Ovarian Neoplasms/*genetics
Female ; Genes, BRCA2 ; Genetic Carrier Screening ; Genetic Testing ; Genotyping Techniques ; Germany ; Humans ; Polymerase Chain Reaction/methods ; Sequence Analysis, DNA
Czasopismo naukowe
Tytuł :
High Level of Gene Transcription at the Embryonic Stage Leads to the Suppression of Heterochromatic Trans-Inactivation in Drosophila melanogaster Adults.
Autorzy :
Solodovnikov AA; Institute of Molecular Genetics of the Russian Academy of Sciences, Moscow, 123182, Russia.
Gvozdev VA; Institute of Molecular Genetics of the Russian Academy of Sciences, Moscow, 123182, Russia.
Lavrov SA; Institute of Molecular Genetics of the Russian Academy of Sciences, Moscow, 123182, Russia. .
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Źródło :
Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2020 Apr; Vol. 85 (4), pp. 472-479.
Typ publikacji :
Journal Article
MeSH Terms :
Epigenetic Repression*
Gene Silencing*
Heterochromatin*
Transcription, Genetic*
Drosophila melanogaster/*embryology
Drosophila melanogaster/*genetics
Embryonic Development/*genetics
Animals ; Genes, Reporter ; Transgenes
Czasopismo naukowe
Tytuł :
HDAC11 restricts HBV replication through epigenetic repression of cccDNA transcription.
Autorzy :
Yuan Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; University of Chinese Academy of Sciences, Beijing, China.
Zhao K; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Yao Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Liu C; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; University of Chinese Academy of Sciences, Beijing, China.
Chen Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; University of Chinese Academy of Sciences, Beijing, China.
Li J; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; School of Pharmacy, Nankai University, Tianjin, China.
Wang Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Pei R; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Chen J; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Hu X; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Zhou Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Wu C; Department of Laboratory Medicine, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China. Electronic address: .
Chen X; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; University of Chinese Academy of Sciences, Beijing, China; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. Electronic address: .
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Źródło :
Antiviral research [Antiviral Res] 2019 Dec; Vol. 172, pp. 104619. Date of Electronic Publication: 2019 Oct 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenetic Repression*
Hepatitis B virus/*genetics
Histone Deacetylases/*metabolism
Virus Replication/*genetics
Cell Line ; DNA, Circular/metabolism ; DNA, Viral/metabolism ; Epigenesis, Genetic ; Hepatitis B/metabolism ; Hepatitis B/virology ; Histones/metabolism ; Humans ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Targeted de-repression of neuronal Nrf2 inhibits α-synuclein accumulation.
Autorzy :
Baxter PS; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK. .; Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK. .
Márkus NM; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
Dando O; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; Simons Initiative for the Developing Brain, Edinburgh Medical School, University of Edinburgh, Edinburgh, EH8 9XD, UK.
He X; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
Al-Mubarak BR; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
Qiu J; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
Hardingham GE; UK Dementia Research Institute at the University of Edinburgh, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK. .; Deanery of Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK. .
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Źródło :
Cell death & disease [Cell Death Dis] 2021 Feb 26; Vol. 12 (2), pp. 218. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems*
Gene Targeting*
Hydroquinones/*pharmacology
Lewy Body Disease/*therapy
NF-E2-Related Factor 2/*agonists
Neurons/*metabolism
Neuroprotective Agents/*pharmacology
Prosencephalon/*drug effects
alpha-Synuclein/*metabolism
Animals ; Astrocytes/metabolism ; Astrocytes/pathology ; CRISPR-Associated Protein 9/genetics ; CRISPR-Associated Protein 9/metabolism ; Cell Death/drug effects ; Cells, Cultured ; Clustered Regularly Interspaced Short Palindromic Repeats ; Coculture Techniques ; Epigenetic Repression ; Female ; Lewy Body Disease/genetics ; Lewy Body Disease/metabolism ; Lewy Body Disease/pathology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Neurons/drug effects ; Neurons/pathology ; Prosencephalon/metabolism ; Prosencephalon/pathology ; Proteostasis/drug effects ; alpha-Synuclein/genetics
Czasopismo naukowe
Tytuł :
C. elegans germ granules require both assembly and localized regulators for mRNA repression.
Autorzy :
Aoki ST; Department of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, IN, USA. .; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA. .
Lynch TR; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Crittenden SL; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.; Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI, USA.
Bingman CA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Wickens M; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Kimble J; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA. .; Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 12; Vol. 12 (1), pp. 996. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Caenorhabditis elegans/*genetics
Cytoplasmic Granules/*metabolism
Germ Cells/*metabolism
RNA, Messenger/*metabolism
Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Epigenetic Repression ; Gene Expression Regulation ; Promoter Regions, Genetic ; Protein Conformation ; RNA, Messenger/genetics ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
The transcriptional repressors VAL1 and VAL2 recruit PRC2 for genome-wide Polycomb silencing in Arabidopsis.
Autorzy :
Yuan L; State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resource, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.
Song X; State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resource, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.
Zhang L; State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resource, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.; Ministry of Education Key Laboratory for Ecology of Tropical Islands, Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province, College of Life Sciences, Hainan Normal University, Haikou 571158, China.
Yu Y; State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resource, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.
Liang Z; State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resource, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.
Lei Y; State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resource, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.
Ruan J; State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resource, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.
Tan B; Guangdong Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou 510624, China.
Liu J; Guangdong Provincial Key Laboratory for Crop Germplasm Resources Preservation and Utilization, Agro-biological Gene Research Center, Guangdong Academy of Agricultural Sciences, Guangzhou, 510640, China.
Li C; State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resource, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 11; Vol. 49 (1), pp. 98-113.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Plant*
Gene Silencing*
Arabidopsis/*genetics
Arabidopsis Proteins/*metabolism
Polycomb Repressive Complex 2/*metabolism
Repressor Proteins/*metabolism
Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Epigenetic Repression ; Gene Ontology ; Histones/metabolism ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Polycomb Repressive Complex 2/genetics ; Protein Binding ; Protein Interaction Mapping ; Repressor Proteins/deficiency ; Repressor Proteins/genetics ; Response Elements/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
A central role for MeCP2 in the epigenetic repression of miR-200c during epithelial-to-mesenchymal transition of glioma.
Autorzy :
Bian E; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, Anhui Province, China.; Cerebral Vascular Disease Research Center, Anhui Medical University, Hefei, 230601, China.
Chen X; Anhui Province Key Laboratory of Medical Physics and Technology, Center of Medical Physics and Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, No. 350, Shushan Hu Road, Hefei, 230031, Anhui, China.
Xu Y; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, Anhui Province, China.; Cerebral Vascular Disease Research Center, Anhui Medical University, Hefei, 230601, China.
Ji X; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, Anhui Province, China.; Cerebral Vascular Disease Research Center, Anhui Medical University, Hefei, 230601, China.
Cheng M; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, Anhui Province, China.; Cerebral Vascular Disease Research Center, Anhui Medical University, Hefei, 230601, China.
Wang H; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, Anhui Province, China.; Cerebral Vascular Disease Research Center, Anhui Medical University, Hefei, 230601, China.
Fang Z; Anhui Province Key Laboratory of Medical Physics and Technology, Center of Medical Physics and Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, No. 350, Shushan Hu Road, Hefei, 230031, Anhui, China. .
Zhao B; Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, 678 Fu Rong Road, Hefei, 230601, Anhui Province, China. .; Cerebral Vascular Disease Research Center, Anhui Medical University, Hefei, 230601, China. .
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Źródło :
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2019 Aug 20; Vol. 38 (1), pp. 366. Date of Electronic Publication: 2019 Aug 20.
Typ publikacji :
Journal Article
MeSH Terms :
Epigenetic Repression*
Epithelial-Mesenchymal Transition*
Biomarkers, Tumor/*metabolism
Brain Neoplasms/*pathology
Glioma/*pathology
Methyl-CpG-Binding Protein 2/*metabolism
MicroRNAs/*genetics
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Cell Cycle ; Cell Movement ; Cell Proliferation ; Female ; Follow-Up Studies ; Gene Expression Regulation, Neoplastic ; Glioma/genetics ; Glioma/metabolism ; Humans ; Methyl-CpG-Binding Protein 2/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Prognosis ; Signal Transduction ; Survival Rate ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression.
Autorzy :
Bae J; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
Choi SP; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
Isono K; Laboratory Animal Center, Wakayama Medical University, Wakayama, 641-8509, Japan.
Lee JY; Department of Biomedical Science, CHA University, Seongnam, Gyounggi-do, 13488, Republic of Korea.
Park SW; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
Choi CY; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
Han J; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
Kim SH; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
Lee HH; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
Park K; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
Jin HY; Department of Urology, School of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.
Lee SJ; Department of Biomedical Laboratory Science, College of Health Science, Cheongju University, Cheongju-si, 28503, Republic of Korea.
Park CG; Department of Microbiology and Immunology, Cancer Research Institute and Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, 03087, Republic of Korea.
Koseki H; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Lee YS; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
Chun T; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea. .
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Źródło :
Nature communications [Nat Commun] 2019 Aug 02; Vol. 10 (1), pp. 3496. Date of Electronic Publication: 2019 Aug 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenetic Repression*
Cell Movement/*genetics
Hematopoietic Stem Cells/*immunology
Polycomb Repressive Complex 2/*metabolism
Vascular Cell Adhesion Molecule-1/*genetics
Animals ; Bone Marrow Transplantation/adverse effects ; Cell Movement/immunology ; Cells, Cultured ; DNA Methylation/immunology ; Hematopoietic Stem Cell Mobilization/methods ; Hematopoietic Stem Cell Transplantation/adverse effects ; Histones/genetics ; Histones/metabolism ; Mice ; Mice, Knockout ; Models, Animal ; Polycomb Repressive Complex 2/genetics ; Primary Cell Culture ; Vascular Cell Adhesion Molecule-1/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons.
Autorzy :
Seah MKY; Developmental Epigenetics and Disease Group, IMCB, A*STAR, 138673, Singapore.
Wang Y; Developmental Epigenetics and Disease Group, IMCB, A*STAR, 138673, Singapore.
Goy PA; Methyltransferases in Development and Disease Group, IMCB, A*STAR, 138673, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596, Singapore.
Loh HM; Developmental Epigenetics and Disease Group, IMCB, A*STAR, 138673, Singapore.
Peh WJ; Developmental Epigenetics and Disease Group, IMCB, A*STAR, 138673, Singapore.
Low DHP; Methyltransferases in Development and Disease Group, IMCB, A*STAR, 138673, Singapore.
Han BY; Methyltransferases in Development and Disease Group, IMCB, A*STAR, 138673, Singapore.
Wong E; KOre - Knock Out resource, IMB, A*STAR, 138648, Singapore.
Leong EL; KOre - Knock Out resource, IMB, A*STAR, 138648, Singapore.
Wolf G; The Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.
Mzoughi S; Methyltransferases in Development and Disease Group, IMCB, A*STAR, 138673, Singapore.
Wollmann H; NGS Unit of DNA Sequencing Facility, IMCB, A*STAR, 138673, Singapore.
Macfarlan TS; The Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.
Guccione E; Methyltransferases in Development and Disease Group, IMCB, A*STAR, 138673, Singapore.
Messerschmidt DM; Developmental Epigenetics and Disease Group, IMCB, A*STAR, 138673, Singapore .
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Źródło :
Development (Cambridge, England) [Development] 2019 Jul 10; Vol. 146 (19). Date of Electronic Publication: 2019 Jul 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenetic Repression*
Zinc Fingers*
Repressor Proteins/*metabolism
Retroelements/*genetics
Animals ; Base Sequence ; Binding Sites/genetics ; Blastocyst/metabolism ; DNA Methylation/genetics ; Embryo, Mammalian/metabolism ; Evolution, Molecular ; Mice ; Mice, Knockout ; Mouse Embryonic Stem Cells/metabolism ; Protein Binding/genetics ; Rats ; Transcription, Genetic ; Tripartite Motif-Containing Protein 28/metabolism
Czasopismo naukowe
Tytuł :
OCT4 Silencing Triggers Its Epigenetic Repression and Impairs the Osteogenic and Adipogenic Differentiation of Mesenchymal Stromal Cells.
Autorzy :
Malvicini R; Laboratorio de Regulación Génica y Células Madre, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Universidad Favaloro-CONICET, Solís 453, Buenos Aires 1078, Argentina.
Santa-Cruz D; Laboratorio de Regulación Génica y Células Madre, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Universidad Favaloro-CONICET, Solís 453, Buenos Aires 1078, Argentina.
Pacienza N; Laboratorio de Regulación Génica y Células Madre, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Universidad Favaloro-CONICET, Solís 453, Buenos Aires 1078, Argentina.
Yannarelli G; Laboratorio de Regulación Génica y Células Madre, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Universidad Favaloro-CONICET, Solís 453, Buenos Aires 1078, Argentina. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Jul 03; Vol. 20 (13). Date of Electronic Publication: 2019 Jul 03.
Typ publikacji :
Journal Article
MeSH Terms :
Adipogenesis*
Epigenetic Repression*
Osteogenesis*
Mesenchymal Stem Cells/*metabolism
Octamer Transcription Factor-3/*genetics
Animals ; DNA Methylation ; Mesenchymal Stem Cells/physiology ; Mice ; Octamer Transcription Factor-3/metabolism ; Octamer Transcription Factor-3/physiology ; Promoter Regions, Genetic
Czasopismo naukowe
Tytuł :
Sodium-coupled monocarboxylate transporter is a target of epigenetic repression in cervical cancer.
Autorzy :
Hernández-Juárez J; Department of Genetics and Molecular Biology, Centre for Research and Advanced Studies of the National Polytechnic Institute, Mexico City 07360, Mexico.
Vargas-Sierra O; Department of Genetics and Molecular Biology, Centre for Research and Advanced Studies of the National Polytechnic Institute, Mexico City 07360, Mexico.
Herrera LA; Biomedical Unit for Cancer Research, Carcinogenesis Laboratory, Department of Basic Research, Instituto de Investigaciones Biomédicas, UNAM/Instituto Nacional de Cancerologia (INCan), Mexico City 14080, Mexico.
Cantú De León D; Department of Gynaecological Oncology, National Cancer Institute, Mexico City 14080, Mexico.
Fernández-Retana J; Biomedical Unit for Cancer Research, Carcinogenesis Laboratory, Department of Basic Research, Instituto de Investigaciones Biomédicas, UNAM/Instituto Nacional de Cancerologia (INCan), Mexico City 14080, Mexico.
Pérez-Plasencia C; Laboratory of Cancer Genomics, National Cancer Institute, Mexico City 14080, Mexico.
López-Camarillo C; Genomic Sciences Graduate Program, Autonomous University of Mexico City, Mexico City 03100, Mexico.
Gariglio P; Department of Genetics and Molecular Biology, Centre for Research and Advanced Studies of the National Polytechnic Institute, Mexico City 07360, Mexico.
Díaz-Chávez J; Biomedical Unit for Cancer Research, Carcinogenesis Laboratory, Department of Basic Research, Instituto de Investigaciones Biomédicas, UNAM/Instituto Nacional de Cancerologia (INCan), Mexico City 14080, Mexico.
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Źródło :
International journal of oncology [Int J Oncol] 2019 May; Vol. 54 (5), pp. 1613-1624. Date of Electronic Publication: 2019 Mar 14.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Epigenetic Repression*
Monocarboxylic Acid Transporters/*genetics
Papillomavirus Infections/*genetics
Uterine Cervical Neoplasms/*genetics
Uterine Cervical Neoplasms/*virology
Adult ; Cell Line, Tumor ; CpG Islands ; DNA Methylation ; Decitabine/pharmacology ; Female ; Gene Expression Regulation, Neoplastic ; HeLa Cells ; Humans ; Hydroxamic Acids/pharmacology ; Middle Aged ; Pyruvic Acid/pharmacology ; Sequence Analysis, DNA ; Young Adult
Czasopismo naukowe
Tytuł :
Polycomb Repressive Complex 2 Proteins EZH1 and EZH2 Regulate Timing of Postnatal Hepatocyte Maturation and Fibrosis by Repressing Genes With Euchromatic Promoters in Mice.
Autorzy :
Grindheim JM; Institute for Regenerative Medicine, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Penn Epigenetics Institute, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Department of Cell and Developmental Biology, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Department of Cancer Biology, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Perelman School of Medicine, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania.
Nicetto D; Institute for Regenerative Medicine, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Penn Epigenetics Institute, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Department of Cell and Developmental Biology, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania.
Donahue G; Institute for Regenerative Medicine, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Penn Epigenetics Institute, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Department of Cell and Developmental Biology, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Perelman School of Medicine, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania.
Zaret KS; Institute for Regenerative Medicine, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Penn Epigenetics Institute, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Department of Cell and Developmental Biology, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania; Perelman School of Medicine, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, Pennsylvania. Electronic address: .
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Źródło :
Gastroenterology [Gastroenterology] 2019 May; Vol. 156 (6), pp. 1834-1848. Date of Electronic Publication: 2019 Jan 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Epigenetic Repression*
Cell Differentiation/*genetics
Enhancer of Zeste Homolog 2 Protein/*genetics
Gene Expression Regulation/*genetics
Liver Cirrhosis/*genetics
Polycomb Repressive Complex 2/*genetics
Animals ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Euchromatin ; Female ; Gene Expression ; Gene Ontology ; Hepatocytes ; Histones/metabolism ; Liver Cirrhosis/pathology ; Male ; Methylation ; Mice ; Polycomb Repressive Complex 2/metabolism ; Promoter Regions, Genetic ; Time Factors
Czasopismo naukowe
Tytuł :
Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression.
Autorzy :
Zhang Y; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China.; Department of General Surgery, Affiliated hospital of Xuzhou Medical University, Xuzhou, 221000, China.
Tang B; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China. .
Song J; Department of General Surgery, Affiliated hospital of Xuzhou Medical University, Xuzhou, 221000, China.
Yu S; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China.
Li Y; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China.
Su H; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China.
He S; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China. .
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Źródło :
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2019 Feb 20; Vol. 38 (1), pp. 92. Date of Electronic Publication: 2019 Feb 20.
Typ publikacji :
Journal Article
MeSH Terms :
Epigenetic Repression*
Basic Helix-Loop-Helix Transcription Factors/*genetics
Carcinoma, Hepatocellular/*genetics
Carrier Proteins/*genetics
Enhancer of Zeste Homolog 2 Protein/*genetics
Liver Neoplasms/*genetics
Adult ; Aged ; Animals ; Carcinogenesis/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; DNA Methylation/genetics ; Disease Progression ; Female ; Hep G2 Cells ; Humans ; Liver Neoplasms/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs/genetics ; Middle Aged ; Transcription, Genetic ; Up-Regulation
Czasopismo naukowe
Tytuł :
MicroRNAs reinforce repression of PRC2 transcriptional targets independently and through a feed-forward regulatory network.
Autorzy :
Shivram H; Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas 78712, USA.
Le SV; Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas 78712, USA.
Iyer VR; Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas 78712, USA.
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Źródło :
Genome research [Genome Res] 2019 Feb; Vol. 29 (2), pp. 184-192. Date of Electronic Publication: 2019 Jan 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenetic Repression*
Gene Regulatory Networks*
MicroRNAs/*metabolism
Polycomb Repressive Complex 2/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Cell Line, Tumor ; Feedback, Physiological ; Gene Expression Profiling ; Histone Code ; Humans
Czasopismo naukowe

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