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Wyszukujesz frazę ""Epithelial Sodium Channel"" wg kryterium: Temat


Tytuł :
An Inhibitor of the Sodium-Hydrogen Exchanger-1 (NHE-1), Amiloride, Reduced Zinc Accumulation and Hippocampal Neuronal Death after Ischemia.
Autorzy :
Kang BS; Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Choi BY; Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Kho AR; Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Lee SH; Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Hong DK; Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Jeong JH; Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Kang DH; Department of Medical Science, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Park MK; Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Suh SW; Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jun 14; Vol. 21 (12). Date of Electronic Publication: 2020 Jun 14.
Typ publikacji :
Journal Article
MeSH Terms :
Acidosis/*prevention & control
Amiloride/*administration & dosage
Brain Ischemia/*drug therapy
Epithelial Sodium Channel Blockers/*administration & dosage
Hippocampus/*metabolism
Zinc/*metabolism
Acidosis/etiology ; Acidosis/metabolism ; Amiloride/pharmacology ; Animals ; Brain Ischemia/complications ; Brain Ischemia/metabolism ; Cell Death/drug effects ; Disease Models, Animal ; Epithelial Sodium Channel Blockers/pharmacology ; Hippocampus/drug effects ; Injections, Intraperitoneal ; Male ; Mice ; Neurons/drug effects ; Neurons/metabolism ; Oxidative Stress/drug effects
Czasopismo naukowe
Tytuł :
First clinical trials of novel ENaC targeting therapy, SPX-101, in healthy volunteers and adults with cystic fibrosis.
Autorzy :
Couroux P; Inflamax Research Limited, Mississauga, Ontario, Canada.
Farias P; Spyryx Biosciences, Inc, Durham, NC, USA.
Rizvi L; Toronto Adult Cystic Fibrosis Centre, St. Michael's Hospital, Toronto, Ontario, Canada.
Griffin K; Toronto Adult Cystic Fibrosis Centre, St. Michael's Hospital, Toronto, Ontario, Canada.
Hudson C; Spyryx Biosciences, Inc, Durham, NC, USA.
Crowder T; Spyryx Biosciences, Inc, Durham, NC, USA. Electronic address: .
Tarran R; Marsico Lung Institute, Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, USA.
Tullis E; Toronto Adult Cystic Fibrosis Centre, St. Michael's Hospital, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, Canada.
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Źródło :
Pulmonary pharmacology & therapeutics [Pulm Pharmacol Ther] 2019 Oct; Vol. 58, pp. 101819. Date of Electronic Publication: 2019 Jul 11.
Typ publikacji :
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Cystic Fibrosis/*drug therapy
Epithelial Sodium Channel Blockers/*pharmacokinetics
Epithelial Sodium Channel Blockers/*therapeutic use
Administration, Inhalation ; Adult ; Dose-Response Relationship, Drug ; Double-Blind Method ; Epithelial Sodium Channel Blockers/adverse effects ; Epithelial Sodium Channels ; Female ; Glycoproteins/metabolism ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; Phosphoproteins/metabolism
Czasopismo naukowe
Tytuł :
Is amiloride a promising cardiovascular medication to persist in the COVID-19 crisis?
Autorzy :
Adil MS; Clinical and Experimental Therapeutics, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA, USA.
Narayanan SP; Clinical and Experimental Therapeutics, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA, USA.
Somanath PR; Clinical and Experimental Therapeutics, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA, USA.
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Źródło :
Drug discoveries & therapeutics [Drug Discov Ther] 2020 Nov 04; Vol. 14 (5), pp. 256-258. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article
MeSH Terms :
Amiloride/*pharmacology
Antiviral Agents/*pharmacology
Betacoronavirus/*drug effects
Coronavirus Infections/*drug therapy
Epithelial Sodium Channel Blockers/*pharmacology
Pneumonia, Viral/*drug therapy
Respiratory Mucosa/*drug effects
Virus Internalization/*drug effects
A549 Cells ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus/pathogenicity ; COVID-19 ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/enzymology ; Coronavirus Infections/enzymology ; Coronavirus Infections/virology ; Down-Regulation ; Host-Pathogen Interactions ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/enzymology ; Pneumonia, Viral/virology ; Receptors, Virus/metabolism ; Respiratory Mucosa/enzymology ; Respiratory Mucosa/virology ; SARS-CoV-2
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Lovastatin attenuates hypertension induced by renal tubule-specific knockout of ATP-binding cassette transporter A1, by inhibiting epithelial sodium channels.
Autorzy :
Wu MM; Departments of Cardiology and Clinic Pharmacy, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin Medical University Cancer Hospital, Harbin, China.; Department of Physiology, Emory University School of Medicine, Atlanta, Georgia.
Liang C; Departments of Cardiology and Clinic Pharmacy, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin Medical University Cancer Hospital, Harbin, China.
Yu XD; Departments of Cardiology and Clinic Pharmacy, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin Medical University Cancer Hospital, Harbin, China.
Song BL; Departments of Cardiology and Clinic Pharmacy, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin Medical University Cancer Hospital, Harbin, China.; Department of Physiology, Emory University School of Medicine, Atlanta, Georgia.
Yue Q; Department of Physiology, Emory University School of Medicine, Atlanta, Georgia.
Zhai YJ; Department of Physiology, Emory University School of Medicine, Atlanta, Georgia.
Linck V; Department of Physiology, Emory University School of Medicine, Atlanta, Georgia.
Cai YX; Departments of Cardiology and Clinic Pharmacy, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin Medical University Cancer Hospital, Harbin, China.
Niu N; Departments of Cardiology and Clinic Pharmacy, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin Medical University Cancer Hospital, Harbin, China.
Yang X; Departments of Cardiology and Clinic Pharmacy, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin Medical University Cancer Hospital, Harbin, China.
Zhang BL; Departments of Cardiology and Clinic Pharmacy, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin Medical University Cancer Hospital, Harbin, China.
Wang QS; Departments of Cardiology and Clinic Pharmacy, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin Medical University Cancer Hospital, Harbin, China.
Zou L; Department of Physiology, Emory University School of Medicine, Atlanta, Georgia.
Zhang S; Department of Physiology, Emory University School of Medicine, Atlanta, Georgia.
Thai TL; Department of Physiology, Emory University School of Medicine, Atlanta, Georgia.
Ma J; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Atlanta Veterans Affairs Medical Center, Decatur, Georgia.
Sutliff RL; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Atlanta Veterans Affairs Medical Center, Decatur, Georgia.
Zhang ZR; Departments of Cardiology and Clinic Pharmacy, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin Medical University Cancer Hospital, Harbin, China.
Ma HP; Department of Physiology, Emory University School of Medicine, Atlanta, Georgia.
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2019 Sep; Vol. 176 (18), pp. 3695-3711. Date of Electronic Publication: 2019 Jul 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
ATP Binding Cassette Transporter 1/*genetics
Antihypertensive Agents/*therapeutic use
Epithelial Sodium Channel Blockers/*therapeutic use
Hypertension/*drug therapy
Lovastatin/*therapeutic use
Animals ; Anticholesteremic Agents/pharmacology ; Antihypertensive Agents/pharmacology ; Epithelial Sodium Channel Blockers/pharmacology ; Epithelial Sodium Channels/physiology ; Hypertension/metabolism ; Hypertension/physiopathology ; Kidney Tubules/metabolism ; Lovastatin/pharmacology ; Male ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Novel indole and benzothiophene ring derivatives showing differential modulatory activity against human epithelial sodium channel subunits, ENaC β and γ.
Autorzy :
Kasahara Y; a Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences , The University of Tokyo , Tokyo , Japan.
Sakurai T; a Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences , The University of Tokyo , Tokyo , Japan.
Matsuda R; a Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences , The University of Tokyo , Tokyo , Japan.
Narukawa M; a Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences , The University of Tokyo , Tokyo , Japan.
Yasuoka A; a Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences , The University of Tokyo , Tokyo , Japan.
Mori N; a Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences , The University of Tokyo , Tokyo , Japan.
Watanabe H; a Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences , The University of Tokyo , Tokyo , Japan.
Okabe T; b Drug Discovery Initiative (DDI) , The University of Tokyo , Tokyo , Japan.
Kojima H; b Drug Discovery Initiative (DDI) , The University of Tokyo , Tokyo , Japan.
Abe K; a Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences , The University of Tokyo , Tokyo , Japan.; c Kanagawa Institute of Industrial Science and Technology (KISTEC) , Kanagawa , Japan.
Misaka T; a Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences , The University of Tokyo , Tokyo , Japan.
Asakura T; a Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences , The University of Tokyo , Tokyo , Japan.
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Źródło :
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2019 Feb; Vol. 83 (2), pp. 243-250. Date of Electronic Publication: 2018 Oct 21.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial Sodium Channel Agonists/*pharmacology
Epithelial Sodium Channels/*drug effects
Indoles/*chemistry
Thiophenes/*chemistry
Animals ; Epithelial Sodium Channel Agonists/chemistry ; HEK293 Cells ; High-Throughput Screening Assays ; Humans ; Mice
Czasopismo naukowe
Tytuł :
Epithelial sodium channel blockade and new β-ENaC polymorphisms among normotensive and hypertensive adult Nigerians.
Autorzy :
Elias SO; Department of Physiology, Lagos State University College of Medicine, Lagos, Nigeria.
Sofola OA; Department of Physiology, College of Medicine University of Lagos, Lagos, Nigeria.
Jaja SI; Department of Physiology, College of Medicine University of Lagos, Lagos, Nigeria.
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Źródło :
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2019; Vol. 41 (2), pp. 144-151. Date of Electronic Publication: 2018 Mar 26.
Typ publikacji :
Journal Article
MeSH Terms :
Amiloride/*pharmacology
Blood Pressure/*drug effects
Epithelial Sodium Channel Blockers/*pharmacology
Epithelial Sodium Channels/*genetics
Hypertension/*drug therapy
Hypertension/*genetics
Adult ; Amiloride/therapeutic use ; Case-Control Studies ; Epithelial Sodium Channel Blockers/therapeutic use ; Humans ; Hypertension/physiopathology ; Nigeria ; Polymorphism, Genetic ; Sodium/blood ; Sodium Chloride, Dietary/pharmacology
Czasopismo naukowe
Tytuł :
Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification.
Autorzy :
Dionisi M; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
Ruffinatti FA; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
Riva B; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
Lim D; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
Canta A; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Meregalli C; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Fumagalli G; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Monza L; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Ferrer-Montiel A; Biología Molecular y Celular, Universidad Miguel Hernández de Elche, 03202 Elche (Alicante), Spain.
Fernandez-Carvajal A; Biología Molecular y Celular, Universidad Miguel Hernández de Elche, 03202 Elche (Alicante), Spain.
Cavaletti G; Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy.
Genazzani AA; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
Distasi C; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 28; Vol. 21 (19). Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*adverse effects
Ganglia, Spinal/*drug effects
Neurons/*drug effects
Oxaliplatin/*adverse effects
Peripheral Nervous System Diseases/*genetics
Potassium Channels, Tandem Pore Domain/*genetics
Sodium-Hydrogen Exchanger 1/*genetics
Action Potentials/drug effects ; Action Potentials/physiology ; Amiloride/pharmacology ; Animals ; Capsaicin/pharmacology ; Epithelial Sodium Channel Blockers/pharmacology ; Ganglia, Spinal/metabolism ; Ganglia, Spinal/pathology ; Humans ; Hydrogen-Ion Concentration/drug effects ; Male ; Mice ; Mice, Inbred BALB C ; Models, Biological ; Neurons/metabolism ; Neurons/pathology ; Patch-Clamp Techniques ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/metabolism ; Peripheral Nervous System Diseases/pathology ; Potassium Channels, Tandem Pore Domain/agonists ; Potassium Channels, Tandem Pore Domain/metabolism ; Primary Cell Culture ; Sodium-Hydrogen Exchanger 1/antagonists & inhibitors ; Sodium-Hydrogen Exchanger 1/metabolism ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
Sodium Imbalance in Mice Results Primarily in Compensatory Gene Regulatory Responses in Kidney and Colon, but Not in Taste Tissue.
Autorzy :
Lossow K; Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.; Department of Molecular Nutritional Physiology, Institute of Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Str. 24, 07743 Jena, Germany.
Meyerhof W; Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.; Center for Integrative Physiology and Molecular Medicine, Saarland University, Kirrbergerstr., Bldg. 48, 66421 Homburg, Germany.
Behrens M; Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.; Leibniz-Institute for Food Systems Biology at the Technical University of Munich, Lise-Meitner-Str. 34, 85354 Freising, Germany.
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Źródło :
Nutrients [Nutrients] 2020 Apr 03; Vol. 12 (4). Date of Electronic Publication: 2020 Apr 03.
Typ publikacji :
Journal Article
MeSH Terms :
Colon/*metabolism
Gene Expression Regulation/*drug effects
Kidney/*metabolism
Sodium, Dietary/*administration & dosage
Taste/*physiology
Water-Electrolyte Balance/*drug effects
Amiloride/pharmacology ; Animals ; Epithelial Sodium Channel Blockers/pharmacology ; Epithelial Sodium Channels/genetics ; Epithelial Sodium Channels/metabolism ; Mice ; Sodium/metabolism ; Tongue/metabolism
Czasopismo naukowe
Tytuł :
Azithromycin Inhibits Constitutive Airway Epithelial Sodium Channel Activation in Vitro and Modulates Downstream Pathogenesis in Vivo.
Autorzy :
Fujikawa H; Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University.; Program for Leading Graduate Schools 'HIGO (Health life science: Interdisciplinary and Glocal Oriented) Program,' Kumamoto University.
Kawakami T; Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University.
Nakashima R; Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University.
Nasu A; Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University.
Kamei S; Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University.; Program for Leading Graduate Schools 'HIGO (Health life science: Interdisciplinary and Glocal Oriented) Program,' Kumamoto University.; Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University.
Nohara H; Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University.; Program for Leading Graduate Schools 'HIGO (Health life science: Interdisciplinary and Glocal Oriented) Program,' Kumamoto University.
Eto Y; Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University.
Ueno-Shuto K; Laboratory of Pharmacology, Division of Life Science, Faculty of Pharmaceutical Sciences, Sojo University.
Takeo T; Division of Reproductive Engineering, Center for Animal Resources and Development (CARD), Kumamoto University.
Nakagata N; Division of Reproductive Engineering, Center for Animal Resources and Development (CARD), Kumamoto University.
Suico MA; Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University.; Global Center for Natural Resources Sciences, Faculty of Life Sciences, Kumamoto University.
Kai H; Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University.; Global Center for Natural Resources Sciences, Faculty of Life Sciences, Kumamoto University.
Shuto T; Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University.; Global Center for Natural Resources Sciences, Faculty of Life Sciences, Kumamoto University.
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Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2020 Apr 01; Vol. 43 (4), pp. 725-730. Date of Electronic Publication: 2020 Jan 31.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Azithromycin/*pharmacology
Epithelial Sodium Channel Agonists/*pharmacology
Epithelial Sodium Channels/*physiology
Animals ; Cell Line ; Epithelial Sodium Channels/genetics ; Forced Expiratory Volume ; Humans ; Lung/drug effects ; Lung/pathology ; Lung/physiology ; Male ; Mice, Transgenic ; Vital Capacity
Czasopismo naukowe
Tytuł :
The epithelial sodium channel (ENaC) as a therapeutic target for cystic fibrosis.
Autorzy :
Shei RJ; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; The Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Peabody JE; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Medical Scientist (MD/PhD) Training Program, University of Alabama at Birmingham, Birmingham, AL, USA; The Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Kaza N; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; The Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Rowe SM; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Cell Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA; The Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: .
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Źródło :
Current opinion in pharmacology [Curr Opin Pharmacol] 2018 Dec; Vol. 43, pp. 152-165. Date of Electronic Publication: 2018 Oct 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Cystic Fibrosis/*drug therapy
Epithelial Sodium Channel Blockers/*therapeutic use
Epithelial Sodium Channels/*drug effects
Lung/*drug effects
Mucociliary Clearance/*drug effects
Animals ; Cystic Fibrosis/genetics ; Cystic Fibrosis/metabolism ; Cystic Fibrosis/physiopathology ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Diffusion of Innovation ; Drug Design ; Epithelial Sodium Channel Blockers/adverse effects ; Epithelial Sodium Channels/metabolism ; Genetic Predisposition to Disease ; Humans ; Lung/metabolism ; Lung/physiopathology ; Molecular Targeted Therapy ; Mutation ; Phenotype ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Caenorhabditis elegans body wall muscles sense mechanical signals with an amiloride-sensitive cation channel.
Autorzy :
Yan Z; Neuroscience Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, 3800, Australia.
Su Z; Neuroscience Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, 3800, Australia.
Cheng X; Neuroscience Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, 3800, Australia.
Liu J; Neuroscience Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, 3800, Australia. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jun 25; Vol. 527 (2), pp. 581-587. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Amiloride/*pharmacology
Caenorhabditis elegans/*physiology
Caenorhabditis elegans Proteins/*metabolism
Epithelial Sodium Channel Blockers/*pharmacology
Ion Channels/*metabolism
Mechanoreceptors/*metabolism
Animals ; Biomechanical Phenomena/drug effects ; Caenorhabditis elegans/drug effects ; Epithelial Sodium Channels/metabolism ; Mechanoreceptors/drug effects ; Mechanotransduction, Cellular/drug effects ; Muscles/drug effects ; Muscles/physiology ; Patch-Clamp Techniques ; TRPC Cation Channels/metabolism
Czasopismo naukowe
Tytuł :
All-Electrical Ca -Independent Signal Transduction Mediates Attractive Sodium Taste in Taste Buds.
Autorzy :
Nomura K; Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto, Kyoto 602-8566, Japan.
Nakanishi M; Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto, Kyoto 602-8566, Japan.
Ishidate F; Center for Meso-Bio Single-Molecule Imaging, Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto, Kyoto 606-8501, Japan.
Iwata K; Department of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto, Kyoto 602-8566, Japan.
Taruno A; Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto, Kyoto 602-8566, Japan; Japan Science and Technology Agency, PRESTO, Kawaguchi, Saitama 332-0012, Japan. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Jun 03; Vol. 106 (5), pp. 816-829.e6. Date of Electronic Publication: 2020 Mar 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Action Potentials/*physiology
Calcium/*metabolism
Epithelial Sodium Channels/*metabolism
Sodium/*metabolism
Taste/*physiology
Taste Buds/*cytology
Action Potentials/drug effects ; Amiloride/pharmacology ; Animals ; Calcium Channels/metabolism ; Chemoreceptor Cells/metabolism ; Chemoreceptor Cells/physiology ; Epithelial Sodium Channel Blockers/pharmacology ; Mice ; Neurons, Afferent/metabolism ; Patch-Clamp Techniques ; Signal Transduction/drug effects ; Synaptic Transmission ; Taste Buds/metabolism ; Taste Buds/physiology
Czasopismo naukowe
Tytuł :
Cystic Fibrosis: Emergence of Highly Effective Targeted Therapeutics and Potential Clinical Implications.
Autorzy :
Mall MA; Department of Pediatric Pulmonology, Immunology, and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany.; German Center for Lung Research (DZL), Berlin, Germany.
Mayer-Hamblett N; Department of Pediatrics and.; Department of Biostatistics, University of Washington, Seattle, Washington.; Seattle Children's Hospital, Seattle, Washington.
Rowe SM; Department of Medicine.; Department of Pediatrics, and.; Department of Cell, Developmental and Integrative Biology, Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama.
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2020 May 15; Vol. 201 (10), pp. 1193-1208.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Precision Medicine*
Chloride Channel Agonists/*therapeutic use
Cystic Fibrosis/*drug therapy
Epithelial Sodium Channel Blockers/*therapeutic use
Aminophenols/therapeutic use ; Aminopyridines/therapeutic use ; Benzodioxoles/therapeutic use ; Cystic Fibrosis/genetics ; Cystic Fibrosis/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Humans ; Indoles/therapeutic use ; Molecular Targeted Therapy ; Mucociliary Clearance ; Mutation ; Pyrazoles/therapeutic use ; Pyridines/therapeutic use ; Pyrrolidines/therapeutic use ; Quinolones/therapeutic use
Czasopismo naukowe
Tytuł :
Soluble (pro)renin receptor regulation of ENaC involved in aldosterone signaling in cultured collecting duct cells.
Autorzy :
Wang F; Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.
Luo R; Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.
Peng K; Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.; Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Liu X; Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Xu C; Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.
Lu X; Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.
Soodvilai S; Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Yang T; Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 Mar 01; Vol. 318 (3), pp. F817-F825. Date of Electronic Publication: 2019 Dec 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Epithelial Sodium Channels*
Aldosterone/*metabolism
Kidney Tubules, Collecting/*cytology
Receptors, Cell Surface/*metabolism
Signal Transduction/*physiology
Animals ; Biological Transport ; Cells, Cultured ; Electrophysiological Phenomena ; Epithelial Sodium Channel Blockers/administration & dosage ; Epithelial Sodium Channel Blockers/pharmacology ; Male ; NADPH Oxidase 4/genetics ; NADPH Oxidase 4/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Cell Surface/genetics ; Sodium/metabolism
Czasopismo naukowe
Tytuł :
Greater natriuretic response to ENaC inhibition in male versus female Sprague-Dawley rats.
Autorzy :
Soliman RH; Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Johnston JG; Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Gohar EY; Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Taylor CM; Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Pollock DM; Section of Cardio-renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
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Źródło :
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2020 Feb 01; Vol. 318 (2), pp. R418-R427. Date of Electronic Publication: 2020 Jan 08.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Amiloride/*analogs & derivatives
Epithelial Sodium Channel Blockers/*pharmacology
Epithelial Sodium Channels/*drug effects
Kidney/*drug effects
Natriuresis/*drug effects
Activity Cycles ; Amiloride/pharmacology ; Animals ; Endothelin-1/urine ; Epithelial Sodium Channels/metabolism ; Female ; Kidney/metabolism ; Male ; Ovariectomy ; Rats, Sprague-Dawley ; Renal Elimination/drug effects ; Sex Factors ; Time Factors ; Urodynamics/drug effects
Czasopismo naukowe
Tytuł :
Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition.
Autorzy :
Molina R; Department of Biochemistry, University of Texas Health Science Center at Tyler, TX, USA.
Han DY
Su XF
Zhao RZ
Zhao M
Sharp GM
Chang Y
Ji HL
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Źródło :
Biochimica et biophysica acta [Biochim Biophys Acta] 2011 Jul; Vol. 1808 (7), pp. 1818-26. Date of Electronic Publication: 2011 Mar 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Epithelial Sodium Channel Agonists*
Cyclic AMP/*analogs & derivatives
Thionucleotides/*pharmacology
Animals ; Cells, Cultured ; Cyclic AMP/pharmacology ; Electrochemistry ; Epithelial Sodium Channel Blockers ; Epithelial Sodium Channels/genetics ; Female ; Humans ; Mice ; Mutagenesis, Site-Directed ; Rats ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Urokinase-type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)-mediated sodium retention in experimental nephrotic syndrome.
Autorzy :
Bohnert BN; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD) at the University Tübingen, Tübingen, Germany.
Daiminger S; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.
Wörn M; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.
Sure F; Institute of Cellular and Molecular Physiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Bayern, Germany.
Staudner T; Institute of Cellular and Molecular Physiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Bayern, Germany.
Ilyaskin AV; Institute of Cellular and Molecular Physiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Bayern, Germany.
Batbouta F; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.
Janessa A; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.
Schneider JC; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.
Essigke D; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.
Kanse S; Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Haerteis S; Institute of Anatomy, University of Regensburg, Regensburg, Germany.
Korbmacher C; Institute of Cellular and Molecular Physiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Bayern, Germany.
Artunc F; Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD) at the University Tübingen, Tübingen, Germany.
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Źródło :
Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2019 Dec; Vol. 227 (4), pp. e13286. Date of Electronic Publication: 2019 May 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial Sodium Channels/*metabolism
Sodium/*metabolism
Urokinase-Type Plasminogen Activator/*metabolism
Amiloride/administration & dosage ; Amiloride/pharmacology ; Animals ; Dose-Response Relationship, Drug ; Epithelial Sodium Channel Blockers/administration & dosage ; Epithelial Sodium Channel Blockers/pharmacology ; Epithelial Sodium Channels/genetics ; Gene Expression Regulation/drug effects ; Ion Channel Gating ; Mice ; Mice, Knockout ; Nephrotic Syndrome ; Oocytes ; Urokinase-Type Plasminogen Activator/genetics ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Lipopolysaccharide Inhibits Alpha Epithelial Sodium Channel Expression via MiR-124-5p in Alveolar Type 2  Epithelial Cells.
Autorzy :
Ding Y; Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang 110122, China.
Cui Y; Department of Anesthesiology, First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Zhou Z; Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang 110122, China.
Hou Y; Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang 110122, China.
Pang X; Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang 110122, China.
Nie H; Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang 110122, China.
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Źródło :
BioMed research international [Biomed Res Int] 2020 Mar 03; Vol. 2020, pp. 8150780. Date of Electronic Publication: 2020 Mar 03 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Alveolar Epithelial Cells/*drug effects
Alveolar Epithelial Cells/*metabolism
Epithelial Sodium Channel Blockers/*pharmacology
Epithelial Sodium Channels/*biosynthesis
Lipopolysaccharides/*pharmacology
MicroRNAs/*metabolism
3' Untranslated Regions ; Acute Lung Injury/metabolism ; Amiloride/pharmacology ; Animals ; Culture Media, Conditioned ; Epithelial Sodium Channels/genetics ; Epithelial Sodium Channels/metabolism ; Ion Transport ; Male ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/metabolism ; Mice
Czasopismo naukowe
Tytuł :
Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome.
Autorzy :
Larionov A; Institute of Anatomy, Department of Medicine, University of Fribourg, Fribourg, Switzerland.
Dahlke E; Institute of Anatomy, Christian Albrechts-University Kiel, Kiel, Germany.
Kunke M; Institute of Anatomy, Christian Albrechts-University Kiel, Kiel, Germany.
Zanon Rodriguez L; Institute of Anatomy, Christian Albrechts-University Kiel, Kiel, Germany.
Schiessl IM; Institute of Physiology, University of Regensburg, Regensburg, Germany.
Magnin JL; Service LaboratoireHôpital Fribourg, Fribourg, Switzerland.
Kern U; Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Alli AA; Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida.
Mollet G; Laboratory of Hereditary Kidney Diseases, INSERM UMR 1163, Université Paris Descartes-Sorbonne Paris Cité, Imagine Institute, Paris, France.
Schilling O; Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; BIOSS Center for Biological Signaling Studies, University of Freiburg, Freiburg, Germany.
Castrop H; Institute of Physiology, University of Regensburg, Regensburg, Germany.
Theilig F; Institute of Anatomy, Department of Medicine, University of Fribourg, Fribourg, Switzerland.; Institute of Anatomy, Christian Albrechts-University Kiel, Kiel, Germany.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2019 Oct; Vol. 23 (10), pp. 6543-6553. Date of Electronic Publication: 2019 Jul 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cathepsin B/*metabolism
Epithelial Sodium Channels/*metabolism
Hypertension/*etiology
Hypertension/*metabolism
Nephrotic Syndrome/*complications
Nephrotic Syndrome/*metabolism
Amiloride/pharmacology ; Animals ; Cathepsin B/antagonists & inhibitors ; Cathepsin B/genetics ; Epithelial Sodium Channel Blockers/pharmacology ; Glomerulosclerosis, Focal Segmental/enzymology ; Glomerulosclerosis, Focal Segmental/genetics ; Glomerulosclerosis, Focal Segmental/metabolism ; Glomerulosclerosis, Focal Segmental/urine ; Hypertension/genetics ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Kidney Tubules/cytology ; Kidney Tubules/metabolism ; Lysosomes/enzymology ; Lysosomes/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Transgenic ; Nephrotic Syndrome/genetics ; Proteinuria/metabolism ; Proteolysis ; Sodium/metabolism
Czasopismo naukowe
Tytuł :
Lipoxin A(4) activates alveolar epithelial sodium channel, Na,K-ATPase, and increases alveolar fluid clearance.
Autorzy :
Wang Q; Department of Anesthesia and Critical Care, Second Affiliated Hospital of Wenzhou Medical College, Zhejiang, People's Republic of China.
Lian QQ
Li R
Ying BY
He Q
Chen F
Zheng X
Yang Y
Wu DR
Zheng SX
Huang CJ
Smith FG
Jin SW
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Źródło :
American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2013 May; Vol. 48 (5), pp. 610-8.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial Sodium Channel Agonists/*administration & dosage
Epithelial Sodium Channels/*metabolism
Lipoxins/*administration & dosage
Sodium-Potassium-Exchanging ATPase/*metabolism
Acute Lung Injury/drug therapy ; Acute Lung Injury/immunology ; Acute Lung Injury/metabolism ; Alveolar Epithelial Cells/drug effects ; Alveolar Epithelial Cells/immunology ; Animals ; Cells, Cultured ; Cyclic AMP/metabolism ; Cyclic GMP/metabolism ; Epithelial Sodium Channel Agonists/pharmacology ; Epithelial Sodium Channel Blockers/pharmacology ; Epithelial Sodium Channels/genetics ; Gene Expression/drug effects ; Heptanoic Acids/pharmacology ; Lipopolysaccharides/pharmacology ; Lipoxins/pharmacology ; Male ; Mucociliary Clearance ; Oligopeptides/pharmacology ; Peroxidase/metabolism ; Pulmonary Alveoli/drug effects ; Pulmonary Alveoli/metabolism ; Pulmonary Alveoli/physiopathology ; Rats ; Rats, Sprague-Dawley ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe

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