Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""ErbB Receptors"" wg kryterium: Temat


Tytuł :
His domain protein tyrosine phosphatase and Rabaptin-5 couple endo-lysosomal sorting of EGFR with endosomal maturation.
Autorzy :
Parkinson G; Faculty of Biology, Medicine and Health, Manchester Academic and Health Science Centre, The University of Manchester, Manchester M13 9PT, UK.
Roboti P; Faculty of Biology, Medicine and Health, Manchester Academic and Health Science Centre, The University of Manchester, Manchester M13 9PT, UK.
Zhang L; Faculty of Biology, Medicine and Health, Manchester Academic and Health Science Centre, The University of Manchester, Manchester M13 9PT, UK.
Taylor S; Faculty of Biology, Medicine and Health, Manchester Academic and Health Science Centre, The University of Manchester, Manchester M13 9PT, UK.
Woodman P; Faculty of Biology, Medicine and Health, Manchester Academic and Health Science Centre, The University of Manchester, Manchester M13 9PT, UK.
Pokaż więcej
Źródło :
Journal of cell science [J Cell Sci] 2021 Nov 01; Vol. 134 (21). Date of Electronic Publication: 2021 Nov 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endosomal Sorting Complexes Required for Transport*/genetics
Endosomal Sorting Complexes Required for Transport*/metabolism
Endosomes*/metabolism
ErbB Receptors*/genetics
ErbB Receptors*/metabolism
Vesicular Transport Proteins*
Lysosomes/metabolism ; Protein Domains ; Protein Transport ; Protein Tyrosine Phosphatases/genetics ; Protein Tyrosine Phosphatases/metabolism
Czasopismo naukowe
Tytuł :
A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer.
Autorzy :
Subramaniyan V; Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jalan SP 2, Bandar Saujana Putra, 42610, Jenjarom, Selangor, Malaysia.
Fuloria S; Faculty of Pharmacy & Centre of Excellence for Biomaterials Engineering, AIMST University, Bedong 08100, Kedah, Malaysia.
Gupta G; Department of Pharmacology, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India; Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical Sciences, Saveetha University, Chennai, India.
Kumar DH; Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selngor, 47500, Malaysia.
Sekar M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, 30450, Malaysia.
Sathasivam KV; Faculty of Applied Science & Centre of Excellence for Biomaterials Engineering, AIMST University, Bedong 08100, Kedah, Malaysia.
Sudhakar K; School of Pharmaceutical Sciences (LIT-Pharmacy), Lovely Professional University, Jalandhar, 144411, India.
Alharbi KS; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al-Jouf, Saudi Arabia.
Al-Malki WH; Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Afzal O; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam BinAbdulaziz University, AlKharj, 11942, Saudi Arabia.
Kazmi I; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Al-Abbasi FA; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Altamimi ASA; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam BinAbdulaziz University, AlKharj, 11942, Saudi Arabia.
Fuloria NK; Faculty of Pharmacy & Centre of Excellence for Biomaterials Engineering, AIMST University, Bedong 08100, Kedah, Malaysia. Electronic address: .
Pokaż więcej
Źródło :
Chemico-biological interactions [Chem Biol Interact] 2022 Jan 05; Vol. 351, pp. 109735. Date of Electronic Publication: 2021 Nov 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Breast Neoplasms/*physiopathology
Carcinoma, Non-Small-Cell Lung/*physiopathology
ErbB Receptors/*metabolism
Lung Neoplasms/*physiopathology
Animals ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/genetics ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; ErbB Receptors/antagonists & inhibitors ; Gene Expression Profiling ; Genes, Mitochondrial ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Protein Kinase Inhibitors/therapeutic use ; Signal Transduction/genetics ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
ADAM17 orchestrates Interleukin-6, TNFα and EGF-R signaling in inflammation and cancer.
Autorzy :
Schumacher N; Biochemical Institute, University of Kiel, Germany.
Rose-John S; Biochemical Institute, University of Kiel, Germany. Electronic address: .
Pokaż więcej
Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2022 Jan; Vol. 1869 (1), pp. 119141. Date of Electronic Publication: 2021 Oct 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
ADAM17 Protein/*metabolism
ErbB Receptors/*metabolism
Interleukin-17/*metabolism
Neoplasms/*metabolism
Tumor Necrosis Factor-alpha/*metabolism
ADAM17 Protein/antagonists & inhibitors ; ADAM17 Protein/genetics ; Animals ; Anti-Inflammatory Agents/pharmacology ; ErbB Receptors/genetics ; Humans ; Interleukin-17/genetics ; Protease Inhibitors/pharmacology ; Tumor Necrosis Factor-alpha/genetics
Czasopismo naukowe
Tytuł :
Defucosylated Mouse-Dog Chimeric Anti-EGFR Antibody Exerts Antitumor Activities in Mouse Xenograft Models of Canine Tumors.
Autorzy :
Li G; Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Ohishi T; Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, 18-24 Miyamoto, Numazu-shi 410-0301, Japan.
Kaneko MK; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Takei J; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Mizuno T; Laboratory of Molecular Diagnostics and Therapeutics, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.
Kawada M; Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, 18-24 Miyamoto, Numazu-shi 410-0301, Japan.
Saito M; Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Suzuki H; Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Kato Y; Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
Pokaż więcej
Źródło :
Cells [Cells] 2021 Dec 20; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Xenograft Model Antitumor Assays*
Antibodies, Monoclonal/*pharmacology
Antineoplastic Agents/*pharmacology
ErbB Receptors/*antagonists & inhibitors
Fucose/*metabolism
Recombinant Proteins/*pharmacology
Animals ; Antibody-Dependent Cell Cytotoxicity ; Body Weight/drug effects ; CHO Cells ; Complement System Proteins/metabolism ; Cricetulus ; Dogs ; Epidermal Growth Factor/pharmacology ; ErbB Receptors/metabolism ; Mice ; Tumor Burden/drug effects
Czasopismo naukowe
Tytuł :
EGFR-D770>GY and Other Rare EGFR Exon 20 Insertion Mutations with a G770 Equivalence Are Sensitive to Dacomitinib or Afatinib and Responsive to EGFR Exon 20 Insertion Mutant-Active Inhibitors in Preclinical Models and Clinical Scenarios.
Autorzy :
Kobayashi IS; Department of Medicine, Division of Medical Oncology, Harvard Medical School, Boston, MA 02215, USA.
Viray H; Department of Medicine, Division of Medical Oncology, Harvard Medical School, Boston, MA 02215, USA.
Rangachari D; Department of Medicine, Division of Medical Oncology, Harvard Medical School, Boston, MA 02215, USA.
Kobayashi SS; Department of Medicine, Division of Medical Oncology, Harvard Medical School, Boston, MA 02215, USA.; Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Division of Translational Genomics, Kashiwa 277-8577, Japan.
Costa DB; Department of Medicine, Division of Medical Oncology, Harvard Medical School, Boston, MA 02215, USA.
Pokaż więcej
Źródło :
Cells [Cells] 2021 Dec 17; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Afatinib/*pharmacology
ErbB Receptors/*genetics
Exons/*genetics
Mutagenesis, Insertional/*genetics
Mutation/*genetics
Protein Kinase Inhibitors/*pharmacology
Quinazolinones/*pharmacology
Amino Acid Sequence ; Animals ; Cell Line ; Disease Models, Animal ; ErbB Receptors/chemistry ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Mice ; Neoplasm Staging
Czasopismo naukowe
Tytuł :
Intraperitoneal microbial contamination drives post-surgical peritoneal adhesions by mesothelial EGFR-signaling.
Autorzy :
Zindel J; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. .; Department of Pharmacology and Physiology and Snyder Institute for Chronic Diseases and Department of Microbiology, Immunology & Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. .
Mittner J; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Bayer J; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
April-Monn SL; Clinical Pathology Division and Translational Research Unit, Institute of Pathology, University of Bern, Bern, Switzerland.
Kohler A; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Nusse Y; Department of Pharmacology and Physiology and Snyder Institute for Chronic Diseases and Department of Microbiology, Immunology & Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Dosch M; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Büchi I; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Sanchez-Taltavull D; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Dawson H; Clinical Pathology Division and Translational Research Unit, Institute of Pathology, University of Bern, Bern, Switzerland.
Gomez de Agüero M; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Asahina K; Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis and Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.; Central Research Laboratory, Shiga University of Medical Science, Otsu, Shiga, Japan.
Kubes P; Department of Pharmacology and Physiology and Snyder Institute for Chronic Diseases and Department of Microbiology, Immunology & Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Macpherson AJ; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Stroka D; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Candinas D; Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Dec 16; Vol. 12 (1), pp. 7316. Date of Electronic Publication: 2021 Dec 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelium/*pathology
ErbB Receptors/*metabolism
Tissue Adhesions/*metabolism
Animals ; Disease Models, Animal ; ErbB Receptors/genetics ; Female ; Humans ; Mice ; Mice, Inbred C57BL ; Myofibroblasts ; Peritoneum ; Peritonitis/pathology ; Tissue Adhesions/genetics ; Tissue Adhesions/pathology
Czasopismo naukowe
Tytuł :
Photoactivatable Reporter to Perform Multiplexed and Temporally Controlled Measurements of Kinase and Protease Activity in Single Cells.
Autorzy :
Anttila MM; Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; Department of Bioengineering, University of Washington, Seattle, Washington 98125, United States.
Vickerman BM; Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Wang Q; Division of Chemical Biology and Medicinal Chemistry UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Lawrence DS; Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; Division of Chemical Biology and Medicinal Chemistry UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; Department of Pharmacology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Allbritton NL; Department of Bioengineering, University of Washington, Seattle, Washington 98125, United States.
Pokaż więcej
Źródło :
Analytical chemistry [Anal Chem] 2021 Dec 14; Vol. 93 (49), pp. 16664-16672. Date of Electronic Publication: 2021 Dec 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
ErbB Receptors*/analysis
Peptides*
Peptide Hydrolases/*analysis
Proto-Oncogene Proteins c-akt/*analysis
Kinetics ; Proteolysis ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Effect of WW Domain-Containing Oxidoreductase Gene Polymorphism on Clinicopathological Characteristics of Patients with EGFR Mutant Lung Adenocarcinoma in Taiwan.
Autorzy :
Li JP; School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.; Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Chang JT; Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Ju PC; School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.; Department of Psychiatry, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Hsieh MH; School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.; Department of Psychiatry, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Chao YH; School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.; Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Tsao TC; School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.; Division of Chest, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Hsieh MJ; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan.; College of Medicine, National Chung Hsing University, Taichung 402, Taiwan.
Yang SF; Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.; Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Pokaż więcej
Źródło :
International journal of environmental research and public health [Int J Environ Res Public Health] 2021 Dec 13; Vol. 18 (24). Date of Electronic Publication: 2021 Dec 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma of Lung*/genetics
Carcinoma, Non-Small-Cell Lung*
ErbB Receptors*/genetics
Lung Neoplasms*/genetics
Tumor Suppressor Proteins*
WW Domain-Containing Oxidoreductase*/genetics
Humans ; Mutation ; Polymorphism, Single Nucleotide ; Taiwan/epidemiology
Czasopismo naukowe
Tytuł :
Clinical outcomes of patients taking first-generation EGFR-TKIs may predict the benefits afforded by osimertinib in EGFR T790M-mutant NSCLC patients.
Autorzy :
Meng H; Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, China.
Huang L; Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Wang J; Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Zhou Y; Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Wang M; Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Yang Z; Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Hong X; Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Pokaż więcej
Źródło :
International journal of clinical practice [Int J Clin Pract] 2021 Dec; Vol. 75 (12), pp. e14877. Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
ErbB Receptors*/genetics
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Acrylamides ; Aniline Compounds ; Female ; Humans ; Mutation ; Protein Kinase Inhibitors/therapeutic use ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Dual inhibition of EGFR and IL-6-STAT3 signalling by miR-146b: a potential targeted therapy for epithelial ovarian cancer.
Autorzy :
Yan M; Department of Laboratory Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, P. R. China.
Han M; Center of Reproduction and Genetics, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, Suzhou, Jiangsu, P. R. China.
Yang X; Department of Immunology, School of Medicine, Key Laboratory of Medical Science and Laboratory Medicine, Reproductive Sciences Institute, Jiangsu University, Zhenjiang, Jiangsu, P. R. China.
Shen R; Department of Immunology, School of Medicine, Key Laboratory of Medical Science and Laboratory Medicine, Reproductive Sciences Institute, Jiangsu University, Zhenjiang, Jiangsu, P. R. China.
Wang H; Department of Immunology, School of Medicine, Key Laboratory of Medical Science and Laboratory Medicine, Reproductive Sciences Institute, Jiangsu University, Zhenjiang, Jiangsu, P. R. China.
Zhang L; Department of Immunology, School of Medicine, Key Laboratory of Medical Science and Laboratory Medicine, Reproductive Sciences Institute, Jiangsu University, Zhenjiang, Jiangsu, P. R. China.
Xia S; Department of Immunology, School of Medicine, Key Laboratory of Medical Science and Laboratory Medicine, Reproductive Sciences Institute, Jiangsu University, Zhenjiang, Jiangsu, P. R. China.
Yang P; Department of Gynecology & Obstetrics, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, P. R. China.
Zhai G; Department of Laboratory Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, P. R. China.
Shao Q; Department of Immunology, School of Medicine, Key Laboratory of Medical Science and Laboratory Medicine, Reproductive Sciences Institute, Jiangsu University, Zhenjiang, Jiangsu, P. R. China.
Pokaż więcej
Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1905-1915.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Ovarian Epithelial/*metabolism
ErbB Receptors/*metabolism
Interleukin-6/*metabolism
MicroRNAs/*metabolism
Ovarian Neoplasms/*metabolism
STAT3 Transcription Factor/*metabolism
Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; ErbB Receptors/genetics ; Female ; Gene Expression Regulation ; Gene Knockdown Techniques ; Humans ; Phosphorylation ; Signal Transduction
Czasopismo naukowe
Tytuł :
SIMPLE Is an Endosomal Regulator That Protects Against NAFLD by Targeting the Lysosomal Degradation of EGFR.
Autorzy :
Song J; Department of Cardiology, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Liu Y; Department of Cardiology, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wan J; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Zhao GN; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Wang JC; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Dai Z; Department of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China.
Hu S; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Yang L; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Liu Z; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Fu Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
Dong E; The Institute of Cardiovascular Sciences, Peking University, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China.; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
Tang YD; Department of Cardiology, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
Pokaż więcej
Źródło :
Hepatology (Baltimore, Md.) [Hepatology] 2021 Dec; Vol. 74 (6), pp. 3091-3109. Date of Electronic Publication: 2021 Nov 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-Binding Proteins/*metabolism
ErbB Receptors/*metabolism
Non-alcoholic Fatty Liver Disease/*pathology
Nuclear Proteins/*metabolism
Transcription Factors/*metabolism
Animals ; Biopsy ; Cells, Cultured ; DNA-Binding Proteins/antagonists & inhibitors ; DNA-Binding Proteins/genetics ; Diet, High-Fat/adverse effects ; ErbB Receptors/antagonists & inhibitors ; Female ; Gene Knockdown Techniques ; Hepatocytes ; Humans ; Lipid Metabolism/drug effects ; Lipid Metabolism/genetics ; Liver/metabolism ; Liver/pathology ; Lysosomes/metabolism ; Male ; Mice ; Mice, Knockout ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Nuclear Proteins/genetics ; Primary Cell Culture ; Proteolysis ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Blocking core fucosylation of epidermal growth factor (EGF) receptor prevents peritoneal fibrosis progression.
Autorzy :
Yu C; Department of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Yang N; Department of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Wang W; Department of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Du X; Department of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Tang Q; Department of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Lin H; Department of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Li L; Department of Nephrology, Liaoning Translational Medicine Center of Nephrology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Pokaż więcej
Źródło :
Renal failure [Ren Fail] 2021 Dec; Vol. 43 (1), pp. 869-877.
Typ publikacji :
Journal Article
MeSH Terms :
ErbB Receptors/*metabolism
Fucosyltransferases/*pharmacology
Glycosylation/*drug effects
Peritoneal Dialysis/*methods
Peritoneal Fibrosis/*prevention & control
Peritoneum/*metabolism
Animals ; Chemokine CCL2/metabolism ; Dialysis Solutions ; Disease Models, Animal ; ErbB Receptors/drug effects ; Fucosyltransferases/genetics ; Male ; Peritoneal Fibrosis/metabolism ; Peritoneal Fibrosis/pathology ; Peritoneum/drug effects ; Peritoneum/pathology ; Phosphorylation ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
A Phase II Study of Osimertinib for Radiotherapy-Naive Central Nervous System Metastasis From NSCLC: Results for the T790M Cohort of the OCEAN Study (LOGIK1603/WJOG9116L).
Autorzy :
Yamaguchi H; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Wakuda K; Division of Thoracic Oncology, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Fukuda M; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Clinical Oncology Center, Nagasaki University Hospital, Nagasaki, Japan. Electronic address: .
Kenmotsu H; Division of Thoracic Oncology, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Mukae H; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Ito K; Department of Respiratory Medicine, Matsusaka Municipal Hospital Respiratory Center, Matsusaka, Japan.
Chibana K; Department of Respiratory Medicine, National Hospital Organization, Okinawa National Hospital, Ginowan, Japan.
Inoue K; Department of Respiratory Medicine, Kitakyushu Municipal Medical Center, Kitakyushu, Japan.
Miura S; Department of Internal Medicine, Niigata Cancer Center Hospital, Niigata, Japan.
Tanaka K; Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ebi N; Department of Respiratory Medicine, Iizuka Hospital, Iizuka, Japan.
Suetsugu T; Department of Respiratory Medicine, Sendai Medical Association Hospital, Satsumasendai, Japan.
Harada T; Department of Respiratory Medicine, Japan Community Health Care Organization (JCHO) Kyushu Hospital, Kitakyushu, Japan.
Kirita K; Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Yokoyama T; Department of Respiratory Medicine, Kurashiki Central Hospital, Kurashiki, Japan.
Nakatani Y; Department of Medical Oncology, Osaka City General Hospital, Osaka, Japan.
Yoshimura K; Future Medical Center, Hiroshima University Hospital, Hiroshima, Japan.
Nakagawa K; Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka, Japan.
Yamamoto N; Internal Medicine III, Wakayama Medical University, Wakayama, Japan.
Sugio K; Department of Thoracic and Breast Surgery, Oita University Faculty of Medicine, Oita, Japan; Lung Oncology Group in Kyushu (LOGiK), Fukuoka, Japan.
Pokaż więcej
Źródło :
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2021 Dec; Vol. 16 (12), pp. 2121-2132. Date of Electronic Publication: 2021 Aug 19.
Typ publikacji :
Clinical Trial, Phase II; Journal Article
MeSH Terms :
ErbB Receptors*/genetics
Lung Neoplasms*/drug therapy
Acrylamides ; Aged ; Aniline Compounds ; Central Nervous System ; Humans ; Male ; Mutation ; Protein Kinase Inhibitors
Czasopismo naukowe
Tytuł :
Safety of Surgery after Neoadjuvant Targeted Therapies in Non-Small Cell Lung Cancer: A Narrative Review.
Autorzy :
Marjanski T; Thoracic Surgery Department, Medical University of Gdansk, Sklodowskiej-Curie 3A, 80-211 Gdansk, Poland.
Dziedzic R; Thoracic Surgery Department, Medical University of Gdansk, Sklodowskiej-Curie 3A, 80-211 Gdansk, Poland.
Kowalczyk A; Department of Oncology and Radiotherapy, Medical University of Gdansk, Sklodowskiej-Curie 3A, 80-211 Gdansk, Poland.
Rzyman W; Thoracic Surgery Department, Medical University of Gdansk, Sklodowskiej-Curie 3A, 80-211 Gdansk, Poland.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 12; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anaplastic Lymphoma Kinase/*antagonists & inhibitors
Carcinoma, Non-Small-Cell Lung/*drug therapy
ErbB Receptors/*antagonists & inhibitors
Lung Neoplasms/*drug therapy
Molecular Targeted Therapy/*methods
Protein Kinase Inhibitors/*therapeutic use
Anaplastic Lymphoma Kinase/metabolism ; Carcinoma, Non-Small-Cell Lung/enzymology ; Carcinoma, Non-Small-Cell Lung/surgery ; Diarrhea/chemically induced ; ErbB Receptors/metabolism ; Humans ; Lung Neoplasms/enzymology ; Lung Neoplasms/surgery ; Nausea/chemically induced ; Neoadjuvant Therapy/methods ; Protein Kinase Inhibitors/adverse effects
Czasopismo naukowe
Tytuł :
Noncovalent EGFR T790M/L858R inhibitors based on diphenylpyrimidine scaffold: Design, synthesis, and bioactivity evaluation for the treatment of NSCLC.
Autorzy :
Chen L; College of Pharmacy, Dalian Medical University, Dalian, 116044, PR China.
Zhang Y; College of Pharmacy, Dalian Medical University, Dalian, 116044, PR China.
Tian L; School of Pharmaceutical Engineering, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Wang C; College of Pharmacy, Dalian Medical University, Dalian, 116044, PR China.
Deng T; School of Pharmaceutical Engineering, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Zheng X; College of Pharmacy, Dalian Medical University, Dalian, 116044, PR China.
Wang T; School of Pharmaceutical Engineering, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Li Z; College of Pharmacy, Dalian Medical University, Dalian, 116044, PR China.
Tang Z; College of Pharmacy, Dalian Medical University, Dalian, 116044, PR China.
Meng Q; College of Pharmacy, Dalian Medical University, Dalian, 116044, PR China.
Sun H; College of Pharmacy, Dalian Medical University, Dalian, 116044, PR China.
Li L; College of Pharmacy, Dalian Medical University, Dalian, 116044, PR China. Electronic address: .
Ma X; College of Pharmacy, Dalian Medical University, Dalian, 116044, PR China. Electronic address: .
Xu Y; School of Pharmaceutical Engineering, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: .
Pokaż więcej
Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 05; Vol. 223, pp. 113626. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
ErbB Receptors/*antagonists & inhibitors
Lung Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Pyrimidines/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacokinetics ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; ErbB Receptors/metabolism ; Humans ; Male ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacokinetics ; Pyrimidines/chemical synthesis ; Pyrimidines/metabolism ; Pyrimidines/pharmacokinetics ; Rats, Sprague-Dawley ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Linear Ubiquitination Mediates EGFR-Induced NF-κB Pathway and Tumor Development.
Autorzy :
Hua F; Department of Microbiology and Immunology, Tulane University, New Orleans, LA 70112, USA.
Hao W; Department of Microbiology and Immunology, Tulane University, New Orleans, LA 70112, USA.
Wang L; Department of Microbiology and Immunology, Tulane University, New Orleans, LA 70112, USA.
Li S; Department of Microbiology and Immunology, Tulane University, New Orleans, LA 70112, USA.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 02; Vol. 22 (21). Date of Electronic Publication: 2021 Nov 02.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Processing, Post-Translational*
Ubiquitination*
Breast Neoplasms/*pathology
ErbB Receptors/*metabolism
NF-kappa B/*metabolism
Plakophilins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Animals ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; ErbB Receptors/genetics ; Female ; Humans ; Hydrocarbons, Aromatic/pharmacology ; Mice ; Mice, Nude ; NF-kappa B/genetics ; Phosphorylation ; Plakophilins/genetics ; Signal Transduction ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Tytuł :
Successful Treatment of Afatinib Reversing Epidermal Growth Factor Receptor Exon19Deletion/G724S Mutation Resistance Guided by Protein-Drug Docking.
Autorzy :
Yu N; Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Xu Y; Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Wang X; Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Sun C; Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Qiu S; Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Guo Y; Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Bai M; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, People's Republic of China.
Huang Y; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, People's Republic of China.
Ma K; Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Pokaż więcej
Źródło :
The oncologist [Oncologist] 2021 Nov; Vol. 26 (11), pp. e1903-e1908. Date of Electronic Publication: 2021 Sep 12.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Afatinib*/therapeutic use
ErbB Receptors*/genetics
Adenocarcinoma/*drug therapy
Humans ; Male ; Mutation
Czasopismo naukowe
Tytuł :
Acquired Resistance to Third-Generation EGFR Tyrosine Kinase Inhibitors in Patients With De Novo EGFR -Mutant NSCLC.
Autorzy :
Park HR; Seoul National University Cancer Research Institute, Seoul, Republic of Korea.
Kim TM; Seoul National University Cancer Research Institute, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address: .
Lee Y; Seoul National University Cancer Research Institute, Seoul, Republic of Korea.
Kim S; Seoul National University Cancer Research Institute, Seoul, Republic of Korea; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Park S; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Ju YS; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Kim M; Seoul National University Cancer Research Institute, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Keam B; Seoul National University Cancer Research Institute, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Jeon YK; Seoul National University Cancer Research Institute, Seoul, Republic of Korea; Department of Pathology, Seoul National University Hospital, Seoul, Republic of Korea.
Kim DW; Seoul National University Cancer Research Institute, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Heo DS; Seoul National University Cancer Research Institute, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Pokaż więcej
Źródło :
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2021 Nov; Vol. 16 (11), pp. 1859-1871. Date of Electronic Publication: 2021 Jul 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
ErbB Receptors*/genetics
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Aniline Compounds ; Drug Resistance, Neoplasm/genetics ; Humans ; In Situ Hybridization, Fluorescence ; Mutation ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use
Czasopismo naukowe
Tytuł :
Ensemble Strategies for EGFR Mutation Status Prediction in Lung Cancer.
Autorzy :
Malafaia M
Pereira T
Silva F
Morgado J
Cunha A
Oliveira HP
Pokaż więcej
Źródło :
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2021 Nov; Vol. 2021, pp. 3285-3288.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
ErbB Receptors*/genetics
Lung Neoplasms*/genetics
Humans ; Lung ; Mutation ; Tomography, X-Ray Computed
Czasopismo naukowe
Tytuł :
Split-enzyme immunoassay to monitor EGFR-HER2 heterodimerization on cell surfaces.
Autorzy :
Kim SJ; Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, United States.
Dixon AS; Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, United States.
Owen SC; Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, United States; Department of Biomedical Engineering, Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, United States. Electronic address: .
Pokaż więcej
Źródło :
Acta biomaterialia [Acta Biomater] 2021 Nov; Vol. 135, pp. 225-233. Date of Electronic Publication: 2021 Sep 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antibodies*
ErbB Receptors*/metabolism
Dimerization ; Immunoenzyme Techniques ; Luciferases
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies