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    Tytuł:
    Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease.
    Autorzy:
    Bouziat R; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA.
    Hinterleitner R; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA.
    Brown JJ; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.
    Stencel-Baerenwald JE; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.
    Ikizler M; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
    Mayassi T; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA.
    Meisel M; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA.
    Kim SM; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA.
    Discepolo V; Department of Medicine, University of Chicago, Chicago, IL, USA.; Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, and CeInGe-Biotecnologie Avanzate, Naples, Italy.
    Pruijssers AJ; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
    Ernest JD; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA.
    Iskarpatyoti JA; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
    Costes LM; Department of Medicine, University of Chicago, Chicago, IL, USA.; Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center Rotterdam-Sophia Children's Hospital, Rotterdam, Netherlands.
    Lawrence I; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA.
    Palanski BA; Department of Chemistry, Stanford University, Stanford, CA, USA.
    Varma M; Division of Gastroenterology, Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
    Zurenski MA; Department of Medicine, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA.
    Khomandiak S; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
    McAllister N; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.
    Aravamudhan P; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
    Boehme KW; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
    Hu F; Department of Medicine, University of Chicago, Chicago, IL, USA.
    Samsom JN; Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center Rotterdam-Sophia Children's Hospital, Rotterdam, Netherlands.
    Reinecker HC; Division of Gastroenterology, Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
    Kupfer SS; Department of Medicine, University of Chicago, Chicago, IL, USA.; University of Chicago Celiac Disease Center, University of Chicago, Chicago, IL, USA.
    Guandalini S; University of Chicago Celiac Disease Center, University of Chicago, Chicago, IL, USA.; Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Chicago, Chicago, IL, USA.
    Semrad CE; Department of Medicine, University of Chicago, Chicago, IL, USA.; University of Chicago Celiac Disease Center, University of Chicago, Chicago, IL, USA.
    Abadie V; Department of Microbiology, Infectiology, and Immunology, University of Montreal, and the Centre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Montreal, Quebec, Canada.
    Khosla C; Department of Chemistry, Stanford University, Stanford, CA, USA.; Department of Chemical Engineering, Stanford University, Stanford, CA, USA.; Stanford ChEM-H, Stanford University, Stanford, California, USA.
    Barreiro LB; Department of Genetics, CHU Sainte-Justine Research Center, Montreal, Quebec, Canada.
    Xavier RJ; Division of Gastroenterology, Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
    Ng A; Division of Gastroenterology, Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
    Dermody TS; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. .; Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
    Jabri B; Department of Medicine, University of Chicago, Chicago, IL, USA. .; Committee on Immunology, University of Chicago, Chicago, IL, USA.; University of Chicago Celiac Disease Center, University of Chicago, Chicago, IL, USA.; Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Chicago, Chicago, IL, USA.; Department of Pathology, University of Chicago, Chicago, IL, USA.
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    Źródło:
    Science (New York, N.Y.) [Science] 2017 Apr 07; Vol. 356 (6333), pp. 44-50.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antigens/*immunology
    Celiac Disease/*immunology
    Celiac Disease/*virology
    Glutens/*immunology
    Inflammation/*virology
    Reoviridae Infections/*complications
    Reoviridae Infections/*immunology
    Th1 Cells/*immunology
    Animals ; Diet/adverse effects ; Disease Models, Animal ; Genetic Engineering ; Humans ; Immune Tolerance ; Inflammation/immunology ; Interferon Regulatory Factor-1/genetics ; Interferon Regulatory Factor-1/immunology ; Interferon Type I/genetics ; Interferon Type I/immunology ; Intestines/immunology ; Intestines/pathology ; Intestines/virology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptor, Interferon alpha-beta/genetics ; Reoviridae/genetics
    Czasopismo naukowe
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