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Wyszukujesz frazę ""Estrogen receptor"" wg kryterium: Temat


Tytuł :
[Mechanism of traditional Chinese medicine balancing Yin-Yang by targeting ERα/ERβ and its application in treatment of menopausal syndrome].
Autorzy :
Zhao PW; School of Life Science, Beijing University of Chinese Medicine Beijing 100029, China.
Wang YX; Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing 100700, China.
Niu JZ; School of Chinese Medicine, Beijing University of Chinese Medicine Beijing 100029, China.
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Źródło :
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2020 Aug; Vol. 45 (16), pp. 3770-3775.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Estrogen Receptor beta*
Yin-Yang*
Estrogen Receptor alpha ; Estrogens ; Female ; Humans ; Medicine, Chinese Traditional
Czasopismo naukowe
Tytuł :
Efficacy of a novel orally active SERD AZD9496 against hormone dependent post-menopausal breast cancer depends on inhibition of cellular aromatase activity.
Autorzy :
Kazi A; Department of Pharmacology, United States; Biology Department, Loyola University, Baltimore, MD, 21210, United States.
Goloubeva O; Division of Biostatistics, University of Maryland School of Medicine and University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, 21201, United States.
Schech A; Department of Pharmacology, United States.
Yu S; Department of Pharmacology, United States.
Sabnis GJ; Department of Pharmaceutical Sciences, West Coast University, Los Angeles, CA, 90004, United States; Department of Pharmacology, United States. Electronic address: .
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2020 Sep; Vol. 202, pp. 105697. Date of Electronic Publication: 2020 May 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aromatase Inhibitors/*therapeutic use
Breast Neoplasms/*drug therapy
Cinnamates/*therapeutic use
Indoles/*therapeutic use
Mammary Neoplasms, Experimental/*drug therapy
Selective Estrogen Receptor Modulators/*therapeutic use
Anastrozole/pharmacology ; Anastrozole/therapeutic use ; Animals ; Antineoplastic Agents, Hormonal/pharmacology ; Antineoplastic Agents, Hormonal/therapeutic use ; Aromatase/metabolism ; Aromatase Inhibitors/pharmacology ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Cinnamates/pharmacology ; Estrogen Receptor Antagonists/pharmacology ; Estrogen Receptor Antagonists/therapeutic use ; Estrogen Receptor alpha ; Female ; Fulvestrant/pharmacology ; Fulvestrant/therapeutic use ; Humans ; Indoles/pharmacology ; Mammary Neoplasms, Experimental/metabolism ; Mice, Nude ; Postmenopause ; Selective Estrogen Receptor Modulators/pharmacology
Czasopismo naukowe
Tytuł :
An H3K4me3 reader, BAP18 as an adaptor of COMPASS-like core subunits co-activates ERα action and associates with the sensitivity of antiestrogen in breast cancer.
Autorzy :
Sun G; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City 110122, Liaoning Province, China.
Wang C; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City 110122, Liaoning Province, China.
Wang S; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City 110122, Liaoning Province, China.
Sun H; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City 110122, Liaoning Province, China.
Zeng K; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City 110122, Liaoning Province, China.
Zou R; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City 110122, Liaoning Province, China.
Lin L; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City 110122, Liaoning Province, China.
Liu W; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City 110122, Liaoning Province, China.
Sun N; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City 110122, Liaoning Province, China.
Song H; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City 110122, Liaoning Province, China.
Liu W; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City 110122, Liaoning Province, China.
Zhou T; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City 110122, Liaoning Province, China.
Jin F; Department of Breast Surgery, the First Affiliated Hospital of China Medical University, Shenyang City 110001, Liaoning Province, China.
Shan Z; Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, ShenyangCity110001, Liaoning Province, China.
Zhao Y; Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Sciences, China Medical University, Shenyang City 110122, Liaoning Province, China.; Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, ShenyangCity110001, Liaoning Province, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Nov 04; Vol. 48 (19), pp. 10768-10784.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
Histone Code*
Biomarkers, Tumor/*genetics
Breast Neoplasms/*genetics
DNA-Binding Proteins/*genetics
Estrogen Receptor alpha/*genetics
Animals ; Antineoplastic Agents, Hormonal/pharmacology ; Antineoplastic Agents, Hormonal/therapeutic use ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; DNA-Binding Proteins/metabolism ; Estrogen Receptor Modulators/pharmacology ; Estrogen Receptor Modulators/therapeutic use ; Estrogen Receptor alpha/antagonists & inhibitors ; Estrogen Receptor alpha/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Humans ; MCF-7 Cells ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/genetics ; Mammary Neoplasms, Experimental/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Response Elements
Czasopismo naukowe
Tytuł :
Impaired estrogen signaling underlies regulatory T cell loss-of-function in the chronically inflamed intestine.
Autorzy :
Goodman WA; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106; .
Bedoyan SM; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Havran HL; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Richardson B; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Cameron MJ; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Pizarro TT; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 21; Vol. 117 (29), pp. 17166-17176. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Estrogen Receptor beta/*metabolism
Estrogens/*metabolism
Inflammation/*immunology
Intestines/*immunology
Signal Transduction/*physiology
T-Lymphocytes, Regulatory/*immunology
Adolescent ; Adult ; Animals ; Crohn Disease/immunology ; Disease Models, Animal ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/genetics ; Female ; Glucocorticoids/metabolism ; Humans ; Ileitis/pathology ; Inflammatory Bowel Diseases/immunology ; Intestines/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Transcription Factors/metabolism ; Transforming Growth Factor beta/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Erythropoietin-producing hepatocellular receptor A7 restrains estrogen negative feedback of luteinizing hormone via ephrin A5 in the hypothalamus of female rats.
Autorzy :
Li S; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai, Jiao Tong University, Shanghai, China.; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.
Zhai J; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai, Jiao Tong University, Shanghai, China.; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.
Xu B; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai, Jiao Tong University, Shanghai, China.; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.
Liu J; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai, Jiao Tong University, Shanghai, China.; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.
Chu W; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai, Jiao Tong University, Shanghai, China.; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.
Wang D; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai, Jiao Tong University, Shanghai, China.; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.
Geng X; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai, Jiao Tong University, Shanghai, China.; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.
Chen ZJ; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai, Jiao Tong University, Shanghai, China.; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.; Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China.; Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, China.
Du Y; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai, Jiao Tong University, Shanghai, China.; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China.
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Źródło :
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2020 Jul 01; Vol. 319 (1), pp. E81-E90. Date of Electronic Publication: 2020 May 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ephrin-A5/*metabolism
Estrogen Receptor alpha/*metabolism
Gonadotropin-Releasing Hormone/*metabolism
Hypothalamus/*metabolism
Luteinizing Hormone/*metabolism
Protein Precursors/*metabolism
Animals ; Arcuate Nucleus of Hypothalamus/drug effects ; Arcuate Nucleus of Hypothalamus/metabolism ; Ephrin-A5/drug effects ; Ephrin-A5/genetics ; Estradiol/pharmacology ; Estrogen Receptor beta/metabolism ; Estrogens/pharmacology ; Feedback, Physiological/drug effects ; Feedback, Physiological/physiology ; Female ; Gonadotropin-Releasing Hormone/drug effects ; Hormone Antagonists/pharmacology ; Hypothalamo-Hypophyseal System/drug effects ; Hypothalamo-Hypophyseal System/metabolism ; Hypothalamus/drug effects ; Luteinizing Hormone/drug effects ; Oligopeptides/pharmacology ; Ovariectomy ; Ovary/drug effects ; Ovary/metabolism ; Protein Precursors/drug effects ; Rats ; Receptor, EphA7/genetics ; Receptor, EphA7/metabolism ; Receptor, EphA7/pharmacology ; Recombinant Proteins
Czasopismo naukowe
Tytuł :
Heregulin controls ERα and HER2 signaling in mammospheres of ERα-positive breast cancer cells and interferes with the efficacy of molecular targeted therapy.
Autorzy :
Fukui F; Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan; Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University, Sendai, Japan. Electronic address: .
Hayashi SI; Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University, Sendai, Japan. Electronic address: .
Yamaguchi Y; Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan. Electronic address: .
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2020 Jul; Vol. 201, pp. 105698. Date of Electronic Publication: 2020 May 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neuregulin-1*
Breast Neoplasms/*genetics
Estrogen Receptor alpha/*genetics
Receptor, ErbB-2/*genetics
Antineoplastic Agents, Hormonal/pharmacology ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Estrogen Receptor Antagonists/pharmacology ; Estrogen Receptor alpha/metabolism ; Everolimus/pharmacology ; Female ; Fulvestrant/pharmacology ; Humans ; Molecular Targeted Therapy ; Neoplastic Stem Cells/drug effects ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Effects of ICI 182,780, an ERα and ERβ antagonist, and G-1, a GPER agonist, on autophagy in breast cancer cells.
Autorzy :
Muler ML; Departamento de Farmacologia , Escola Paulista de Medicina , Universidade Federal de São Paulo , São Paulo , SP , Brazil .
Antunes F; Departamento de Farmacologia , Escola Paulista de Medicina , Universidade Federal de São Paulo , São Paulo , SP , Brazil .
Guarache GC; Departamento de Farmacologia , Escola Paulista de Medicina , Universidade Federal de São Paulo , São Paulo , SP , Brazil .
Oliveira RB; Departamento de Ciências Biológicas , Universidade Federal de São Paulo , Diadema , SP , Brazil .
Ureshino RP; Departamento de Ciências Biológicas , Universidade Federal de São Paulo , Diadema , SP , Brazil .
Bincoletto C; Departamento de Farmacologia , Escola Paulista de Medicina , Universidade Federal de São Paulo , São Paulo , SP , Brazil .
Pereira GJDS; Departamento de Farmacologia , Escola Paulista de Medicina , Universidade Federal de São Paulo , São Paulo , SP , Brazil .
Smaili SS; Departamento de Farmacologia , Escola Paulista de Medicina , Universidade Federal de São Paulo , São Paulo , SP , Brazil .
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Źródło :
Einstein (Sao Paulo, Brazil) [Einstein (Sao Paulo)] 2020 Apr 22; Vol. 18, pp. eAO4560. Date of Electronic Publication: 2020 Apr 22 (Print Publication: 2020).
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
Autophagy/*drug effects
Breast Neoplasms/*drug therapy
Breast Neoplasms/*pathology
Estrogen Receptor Antagonists/*pharmacology
Fulvestrant/*pharmacology
Receptors, G-Protein-Coupled/*agonists
Analysis of Variance ; Blotting, Western ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Estrogen Receptor alpha/antagonists & inhibitors ; Estrogen Receptor beta/antagonists & inhibitors ; Female ; Flow Cytometry/methods ; Humans ; MCF-7 Cells ; Receptors, G-Protein-Coupled/analysis ; Reproducibility of Results ; Sirolimus/pharmacology ; Time Factors ; Transfection/methods
Czasopismo naukowe
Tytuł :
A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve.
Autorzy :
Chakravarthi VP; Deprartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Ghosh S; Deprartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas.
Roby KF; Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas.
Wolfe MW; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas.
Rumi MAK; Deprartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas.
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Źródło :
Endocrinology [Endocrinology] 2020 Apr 01; Vol. 161 (4).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Mullerian Hormone/*blood
Estradiol/*blood
Estrogen Receptor beta/*genetics
Ovarian Follicle/*metabolism
Ovarian Reserve/*physiology
Animals ; Estrogen Receptor Modulators/pharmacology ; Estrogen Receptor beta/agonists ; Estrogen Receptor beta/antagonists & inhibitors ; Estrogen Receptor beta/metabolism ; Female ; Mechanistic Target of Rapamycin Complex 1 ; Nitriles/pharmacology ; Ovarian Follicle/drug effects ; Ovarian Reserve/drug effects ; Phosphatidylinositol 3-Kinases/metabolism ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Rats, Transgenic ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Cytoplasmic ERα and NFκB Promote Cell Survival in Mouse Mammary Cancer Cell Lines.
Autorzy :
Smart E; Department of Physiology and Biophysics, College of Medicine, University of Illinois, 835 S. Wolcott, E202 MSB, MC901, Chicago, IL, 60612, USA.
Alejo LH; Department of Physiology and Biophysics, College of Medicine, University of Illinois, 835 S. Wolcott, E202 MSB, MC901, Chicago, IL, 60612, USA.
Frasor J; Department of Physiology and Biophysics, College of Medicine, University of Illinois, 835 S. Wolcott, E202 MSB, MC901, Chicago, IL, 60612, USA. .
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Źródło :
Hormones & cancer [Horm Cancer] 2020 Apr; Vol. 11 (2), pp. 76-86. Date of Electronic Publication: 2020 Feb 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Estrogen Receptor alpha/*metabolism
Mammary Neoplasms, Experimental/*metabolism
NF-kappa B/*metabolism
Animals ; Antineoplastic Agents, Hormonal/pharmacology ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/physiology ; Cell Survival/physiology ; Cytoplasm/metabolism ; Dimethyl Fumarate/pharmacology ; Disease Models, Animal ; Estrogen Receptor alpha/antagonists & inhibitors ; Female ; Humans ; MCF-7 Cells ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/pathology ; Mice ; NF-kappa B/antagonists & inhibitors ; Oxidative Stress/physiology ; Selective Estrogen Receptor Modulators/pharmacology ; Tamoxifen/pharmacology
Czasopismo naukowe
Tytuł :
Accurate assessment of estrogen receptor profiles in non-functioning pituitary adenomas using RT-digital PCR and immunohistochemistry.
Autorzy :
Hattori Y; Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan; Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan. Electronic address: .
Ishii H; Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Tahara S; Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Morita A; Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Ozawa H; Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
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Źródło :
Life sciences [Life Sci] 2020 Nov 01; Vol. 260, pp. 118416. Date of Electronic Publication: 2020 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Adenoma/*pathology
Biomarkers, Tumor/*metabolism
Estrogen Receptor alpha/*metabolism
Estrogen Receptor beta/*metabolism
Pituitary Neoplasms/*pathology
Adenoma/genetics ; Adenoma/metabolism ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Estrogen Receptor alpha/genetics ; Estrogen Receptor beta/genetics ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Pituitary Neoplasms/genetics ; Pituitary Neoplasms/metabolism ; Prognosis ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Important roles of estrogen receptor alpha in tumor progression and anti-estrogen therapy of pancreatic ductal adenocarcinoma.
Autorzy :
Xue J; Department of Pharmaceutics, School of Pharmaceutical Science, Peking University Health Science Center, Beijing 100191, China.
Yao Y; Department of Pharmaceutics, School of Pharmaceutical Science, Peking University Health Science Center, Beijing 100191, China.
Yao Q; Department of Pharmaceutics, School of Pharmaceutical Science, Peking University Health Science Center, Beijing 100191, China.
Tian X; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Feng Y; Department of Pharmaceutics, School of Pharmaceutical Science, Peking University Health Science Center, Beijing 100191, China.
Su H; Department of Pharmaceutics, School of Pharmaceutical Science, Peking University Health Science Center, Beijing 100191, China.
Kong D; Department of Pharmaceutics, School of Pharmaceutical Science, Peking University Health Science Center, Beijing 100191, China.
Cui C; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Yan L; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Hao C; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, China. Electronic address: .
Zhou T; Department of Pharmaceutics, School of Pharmaceutical Science, Peking University Health Science Center, Beijing 100191, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Nov 01; Vol. 260, pp. 118302. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*drug therapy
Carcinoma, Pancreatic Ductal/*drug therapy
Estrogen Receptor Modulators/*therapeutic use
Estrogen Receptor alpha/*physiology
Pancreatic Neoplasms/*drug therapy
Adenocarcinoma/pathology ; Adenocarcinoma/physiopathology ; Animals ; Antineoplastic Combined Chemotherapy Protocols ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Pancreatic Ductal/physiopathology ; Cell Line, Tumor ; Deoxycytidine/administration & dosage ; Deoxycytidine/analogs & derivatives ; Estradiol/pharmacology ; Estrogen Receptor alpha/genetics ; Female ; Gene Expression ; Gene Knockout Techniques ; Humans ; Letrozole/administration & dosage ; Leuprolide/administration & dosage ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/physiopathology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Three-dimensional oxabicycloheptene sulfonate targets the homologous recombination and repair programmes through estrogen receptor α antagonism.
Autorzy :
Wu J; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei, 430072, China.
Yan J; Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China.
Fang P; Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China.
Zhou HB; School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, 430071, China.
Liang K; Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China; Research Center for Medicine and Structural Biology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China; Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China. Electronic address: .
Huang J; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei, 430072, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Jan 28; Vol. 469, pp. 78-88. Date of Electronic Publication: 2019 Oct 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Breast Neoplasms/*drug therapy
Bridged Bicyclo Compounds, Heterocyclic/*pharmacology
Estrogen Receptor Antagonists/*pharmacology
Recombinational DNA Repair/*drug effects
Selective Estrogen Receptor Modulators/*pharmacology
Sulfonic Acids/*pharmacology
Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Apoptosis/drug effects ; Apoptosis/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Cell Cycle Checkpoints/drug effects ; Cell Cycle Checkpoints/genetics ; Cell Line, Tumor ; Chlorocebus aethiops ; Chromatin Immunoprecipitation Sequencing ; Estrogen Receptor Antagonists/therapeutic use ; Estrogen Receptor alpha/antagonists & inhibitors ; Estrogen Receptor alpha/metabolism ; Female ; Humans ; Mice ; Molecular Structure ; Phthalazines/pharmacology ; Phthalazines/therapeutic use ; Piperazines/pharmacology ; Piperazines/therapeutic use ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Promoter Regions, Genetic/genetics ; RNA Polymerase II/antagonists & inhibitors ; RNA Polymerase II/metabolism ; RNA-Seq ; Selective Estrogen Receptor Modulators/therapeutic use ; Structure-Activity Relationship ; Sulfonic Acids/therapeutic use ; Synthetic Lethal Mutations/drug effects ; Vero Cells ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Ventral prostate and mammary gland phenotype in mice with complete deletion of the ERβ gene.
Autorzy :
Warner M; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204; .
Wu WF; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204.
Montanholi L; Center for Innovative Medicine, Department of Biosciences and Nutrition, Karolinska Institutet, Novum, 14186 Stockholm, Sweden.
Nalvarte I; Center for Innovative Medicine, Department of Biosciences and Nutrition, Karolinska Institutet, Novum, 14186 Stockholm, Sweden.
Antonson P; Center for Innovative Medicine, Department of Biosciences and Nutrition, Karolinska Institutet, Novum, 14186 Stockholm, Sweden.
Gustafsson JA; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204; .; Center for Innovative Medicine, Department of Biosciences and Nutrition, Karolinska Institutet, Novum, 14186 Stockholm, Sweden.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 03; Vol. 117 (9), pp. 4902-4909. Date of Electronic Publication: 2020 Feb 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Phenotype*
Sequence Deletion*
Estrogen Receptor beta/*genetics
Mammary Glands, Human/*metabolism
Prostate/*metabolism
Receptors, Androgen/*metabolism
Androgens/metabolism ; Animals ; CRISPR-Cas Systems ; Chemokines/metabolism ; DNA-Binding Proteins/metabolism ; Epithelium/metabolism ; Estrogen Receptor alpha/metabolism ; Estrogens/metabolism ; Eye Proteins ; Female ; Humans ; Hyperplasia/pathology ; Inflammation ; Ki-67 Antigen/metabolism ; Male ; Mice ; Mice, Knockout ; Nerve Tissue Proteins/metabolism ; Prostate/pathology ; RNA, Messenger/metabolism ; Signal Transduction ; Stromal Cells ; Trans-Activators ; Transcription Factors/metabolism ; Transcriptome ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
Mutation of Arginine 264 on ERα (Estrogen Receptor Alpha) Selectively Abrogates the Rapid Signaling of Estradiol in the Endothelium Without Altering Fertility.
Autorzy :
Adlanmerini M; From the INSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires (M.A., C.F., R.Z., M.B., R.S., T.A., F.B., P.G., H.L., C.F., J.-F.A., F.L.), Université de Toulouse, France.
Fébrissy C; From the INSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires (M.A., C.F., R.Z., M.B., R.S., T.A., F.B., P.G., H.L., C.F., J.-F.A., F.L.), Université de Toulouse, France.
Zahreddine R; From the INSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires (M.A., C.F., R.Z., M.B., R.S., T.A., F.B., P.G., H.L., C.F., J.-F.A., F.L.), Université de Toulouse, France.
Vessières E; Institut National de la Santé et de la Recherche Médicale U1083, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 46 015, Université d'Angers, France (E.V., J.F., A.-L.G., D.H.).
Buscato M; From the INSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires (M.A., C.F., R.Z., M.B., R.S., T.A., F.B., P.G., H.L., C.F., J.-F.A., F.L.), Université de Toulouse, France.
Solinhac R; From the INSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires (M.A., C.F., R.Z., M.B., R.S., T.A., F.B., P.G., H.L., C.F., J.-F.A., F.L.), Université de Toulouse, France.
Favre J; Institut National de la Santé et de la Recherche Médicale U1083, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 46 015, Université d'Angers, France (E.V., J.F., A.-L.G., D.H.).
Anquetil T; From the INSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires (M.A., C.F., R.Z., M.B., R.S., T.A., F.B., P.G., H.L., C.F., J.-F.A., F.L.), Université de Toulouse, France.
Guihot AL; Institut National de la Santé et de la Recherche Médicale U1083, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 46 015, Université d'Angers, France (E.V., J.F., A.-L.G., D.H.).
Boudou F; From the INSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires (M.A., C.F., R.Z., M.B., R.S., T.A., F.B., P.G., H.L., C.F., J.-F.A., F.L.), Université de Toulouse, France.
Raymond-Letron I; Institut National Polytechnique, École Nationale Vétérinaire de Toulouse, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Service 006 (I.R.-L.), Université de Toulouse, France.
Chambon P; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Collège de France, Université de Strasbourg, Illkirch, France (P.C.).
Gourdy P; From the INSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires (M.A., C.F., R.Z., M.B., R.S., T.A., F.B., P.G., H.L., C.F., J.-F.A., F.L.), Université de Toulouse, France.
Ohlsson C; Centre for Bone and Arthritis Research Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Sweden (C.O.).
Laurell H; From the INSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires (M.A., C.F., R.Z., M.B., R.S., T.A., F.B., P.G., H.L., C.F., J.-F.A., F.L.), Université de Toulouse, France.
Fontaine C; From the INSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires (M.A., C.F., R.Z., M.B., R.S., T.A., F.B., P.G., H.L., C.F., J.-F.A., F.L.), Université de Toulouse, France.
Metivier R; CNRS, Université de Rennes, IGDR (Institut de Génétique De Rennes) - UMR 6290, France (R.M.).
Le Romancer M; Inserm U1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, France (M.L.R.).
Henrion D; Institut National de la Santé et de la Recherche Médicale U1083, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 46 015, Université d'Angers, France (E.V., J.F., A.-L.G., D.H.).
Arnal JF; From the INSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires (M.A., C.F., R.Z., M.B., R.S., T.A., F.B., P.G., H.L., C.F., J.-F.A., F.L.), Université de Toulouse, France.
Lenfant F; From the INSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires (M.A., C.F., R.Z., M.B., R.S., T.A., F.B., P.G., H.L., C.F., J.-F.A., F.L.), Université de Toulouse, France.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Sep; Vol. 40 (9), pp. 2143-2158. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Estrogen Replacement Therapy*
Point Mutation*
Carotid Artery Injuries/*drug therapy
Endothelium, Vascular/*drug effects
Estradiol/*pharmacology
Estrogen Receptor alpha/*agonists
Estrogens/*pharmacology
Fertility/*drug effects
Mesenteric Arteries/*drug effects
Animals ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Atherosclerosis/prevention & control ; Carotid Artery Injuries/metabolism ; Carotid Artery Injuries/pathology ; Carotid Artery Injuries/physiopathology ; Cell Proliferation/drug effects ; Endothelium, Vascular/injuries ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/physiopathology ; Enzyme Activation ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Estrous Cycle/drug effects ; Female ; Male ; Mesenteric Arteries/metabolism ; Mesenteric Arteries/physiopathology ; Mice, Inbred C57BL ; Nitric Oxide Synthase Type III/metabolism ; Ovariectomy ; Re-Epithelialization/drug effects ; Signal Transduction ; Time Factors ; Uterus/drug effects ; Uterus/metabolism ; Vascular Remodeling/drug effects ; Vasodilation/drug effects
Czasopismo naukowe
Tytuł :
Construction of benzofuranone library via a metal-free, one-pot intermolecular condensation, and their application as efficient estrogen receptor β modulators.
Autorzy :
Peng X; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China. .
Hu Z; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China. .
Zhang J; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China. .
Ning W; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China. .
Zhang S; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China. .
Dong C; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China. .
Shi X; Department of Chemistry, University of South Florida, Tampa, FL 33620-5250, USA. .
Zhou HB; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China. .
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Źródło :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Dec 18; Vol. 55 (97), pp. 14570-14573. Date of Electronic Publication: 2019 Oct 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Benzofurans/*chemistry
Benzofurans/*pharmacology
Estrogen Receptor Modulators/*chemical synthesis
Estrogen Receptor Modulators/*pharmacology
Estrogen Receptor beta/*metabolism
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Benzofurans/chemical synthesis ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Estrogen Receptor Modulators/chemistry ; Estrogen Receptor alpha/antagonists & inhibitors ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/agonists ; Humans ; Models, Molecular ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Pharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen receptor-α degrader activity in antitumor efficacy.
Autorzy :
Wardell SE; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Box 3813, Durham, NC, 27710, USA.
Yllanes AP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Box 3813, Durham, NC, 27710, USA.
Chao CA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Box 3813, Durham, NC, 27710, USA.
Bae Y; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Box 3813, Durham, NC, 27710, USA.
Andreano KJ; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Box 3813, Durham, NC, 27710, USA.
Desautels TK; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Box 3813, Durham, NC, 27710, USA.
Heetderks KA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Box 3813, Durham, NC, 27710, USA.
Blitzer JT; Potrero Hill Therapeutics, San Francisco, CA, 94110, USA.
Norris JD; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Box 3813, Durham, NC, 27710, USA.
McDonnell DP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Box 3813, Durham, NC, 27710, USA. .
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Źródło :
Breast cancer research and treatment [Breast Cancer Res Treat] 2020 Jan; Vol. 179 (1), pp. 67-77. Date of Electronic Publication: 2019 Sep 27.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Hormonal/*pharmacokinetics
Breast Neoplasms/*drug therapy
Estrogen Receptor Antagonists/*pharmacokinetics
Fulvestrant/*pharmacokinetics
Administration, Oral ; Animals ; Antineoplastic Agents, Hormonal/administration & dosage ; Dose-Response Relationship, Drug ; Estrogen Receptor Antagonists/administration & dosage ; Estrogen Receptor alpha/antagonists & inhibitors ; Female ; Fulvestrant/administration & dosage ; Mice ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
[Hot flushes and breast cancer with positive hormone receptors: Mechanisms and management].
Autorzy :
Cavadias I; Institut Curie, département de chirurgie oncologique, Saint-Cloud, France. Electronic address: .
Rouzier R; Institut Curie, département de chirurgie oncologique, Saint-Cloud, France; Institut Curie, Inserm U900, Saint-Cloud, France.
Lerebours F; Institut Curie, département d'oncologie médicale, Saint-Cloud, France.
Héquet D; Institut Curie, département de chirurgie oncologique, Saint-Cloud, France; Institut Curie, Inserm U900, Saint-Cloud, France.
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Transliterated Title :
Bouffées de chaleur et cancer du sein avec récepteurs hormonaux positifs : mécanismes et prise en charge.
Źródło :
Bulletin du cancer [Bull Cancer] 2020 Nov; Vol. 107 (11), pp. 1171-1185. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents, Hormonal/*therapeutic use
Aromatase Inhibitors/*therapeutic use
Breast Neoplasms/*chemistry
Breast Neoplasms/*drug therapy
Hot Flashes/*etiology
Selective Estrogen Receptor Modulators/*therapeutic use
Contraindications, Drug ; Estrogen Replacement Therapy/adverse effects ; Female ; Fulvestrant/therapeutic use ; Humans ; Kisspeptins/physiology ; Ovary/drug effects ; Ovary/surgery ; Receptors, Neurokinin-3/antagonists & inhibitors ; Selective Estrogen Receptor Modulators/administration & dosage ; Tamoxifen/administration & dosage ; Tamoxifen/therapeutic use
Czasopismo naukowe
Tytuł :
Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer.
Autorzy :
Lee KM; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Guerrero-Zotano AL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Servetto A; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Sudhan DR; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Lin CC; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Formisano L; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Jansen VM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
González-Ericsson P; Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Sanders ME; Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Stricker TP; Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Raj G; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Dean KM; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Fiolka R; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Cantley LC; Meyer Cancer Center, Weill Cornell Medicine College, New York, NY, 10065, USA.
Hanker AB; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Arteaga CL; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. .; Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 30; Vol. 11 (1), pp. 5488. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Breast Neoplasms/*drug therapy
Breast Neoplasms/*genetics
Estrogen Receptor Modulators/*pharmacology
Phosphatidylinositol 3-Kinases/*metabolism
Proteins/*genetics
Proteins/*metabolism
Signal Transduction/*drug effects
Animals ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Disease Models, Animal ; Drug Resistance, Neoplasm ; Estrogen Antagonists/pharmacology ; Estrogen Receptor Modulators/therapeutic use ; Estrogens ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Insulin ; Mice, Nude ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Pharmacology and Molecular Mechanisms of Clinically Relevant Estrogen Estetrol and Estrogen Mimic BMI-135 for the Treatment of Endocrine-Resistant Breast Cancer.
Autorzy :
Abderrahman B; Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (B.A., P.Y.M., J.S.H., P.F., V.C.J.); Coriolan Dragulescu Institute of Chemistry, Romanian Academy, Timisoara, Romania (R.F.C.); and Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (R.X., D.A.T., G.R.J.T.).
Maximov PY; Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (B.A., P.Y.M., J.S.H., P.F., V.C.J.); Coriolan Dragulescu Institute of Chemistry, Romanian Academy, Timisoara, Romania (R.F.C.); and Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (R.X., D.A.T., G.R.J.T.).
Curpan RF; Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (B.A., P.Y.M., J.S.H., P.F., V.C.J.); Coriolan Dragulescu Institute of Chemistry, Romanian Academy, Timisoara, Romania (R.F.C.); and Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (R.X., D.A.T., G.R.J.T.).
Hanspal JS; Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (B.A., P.Y.M., J.S.H., P.F., V.C.J.); Coriolan Dragulescu Institute of Chemistry, Romanian Academy, Timisoara, Romania (R.F.C.); and Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (R.X., D.A.T., G.R.J.T.).
Fan P; Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (B.A., P.Y.M., J.S.H., P.F., V.C.J.); Coriolan Dragulescu Institute of Chemistry, Romanian Academy, Timisoara, Romania (R.F.C.); and Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (R.X., D.A.T., G.R.J.T.).
Xiong R; Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (B.A., P.Y.M., J.S.H., P.F., V.C.J.); Coriolan Dragulescu Institute of Chemistry, Romanian Academy, Timisoara, Romania (R.F.C.); and Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (R.X., D.A.T., G.R.J.T.).
Tonetti DA; Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (B.A., P.Y.M., J.S.H., P.F., V.C.J.); Coriolan Dragulescu Institute of Chemistry, Romanian Academy, Timisoara, Romania (R.F.C.); and Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (R.X., D.A.T., G.R.J.T.).
Thatcher GRJ; Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (B.A., P.Y.M., J.S.H., P.F., V.C.J.); Coriolan Dragulescu Institute of Chemistry, Romanian Academy, Timisoara, Romania (R.F.C.); and Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (R.X., D.A.T., G.R.J.T.).
Jordan VC; Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (B.A., P.Y.M., J.S.H., P.F., V.C.J.); Coriolan Dragulescu Institute of Chemistry, Romanian Academy, Timisoara, Romania (R.F.C.); and Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (R.X., D.A.T., G.R.J.T.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2020 Oct; Vol. 98 (4), pp. 364-381. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Breast Neoplasms/*genetics
Drug Resistance, Neoplasm/*drug effects
Estetrol/*pharmacology
Estrogen Receptor alpha/*metabolism
Estrogens/*pharmacology
Unfolded Protein Response/*drug effects
Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Estrogen Receptor alpha/chemistry ; Estrogens/chemical synthesis ; Estrogens/chemistry ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Regulatory Networks/drug effects ; Humans ; MCF-7 Cells ; Molecular Mimicry ; Molecular Structure
Czasopismo naukowe
Tytuł :
Calcium and Phosphorus Levels in Saliva are Influenced by Genetic Polymorphisms in Estrogen Receptor Alpha and Microrna17.
Autorzy :
Küchler EC; Department of Pediatric Dentistry, Ribeirão Preto Dental School, USP - Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Gerlach RF; Department of Morphology, Physiology and Basic Pathology, Ribeirão Preto Dental School, USP - Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Cunha AS; Department of Pediatric Dentistry, Ribeirão Preto Dental School, USP - Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Ramazzotto LA; Department of Pediatric Dentistry, Ribeirão Preto Dental School, USP - Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Spada PP; School of Health Sciences, UP - Universidade Positivo, Curitiba, Brazil.
Nelson-Filho P; Department of Pediatric Dentistry, Ribeirão Preto Dental School, USP - Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Ramos J; Department of Morphology, Physiology and Basic Pathology, Ribeirão Preto Dental School, USP - Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Pecharki GD; Department of Community Health, UFPR - Universidade Federal do Paraná, Curitiba, Brazil.
Barbosa F Jr; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirao Preto, USP - Universidade de São Paulo, Ribeirão Preto, Brazil.
Vieira AR; Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA,USA.; Center for Health and Biological Sciences, PUCPR - Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Trevilatto PC; Center for Health and Biological Sciences, PUCPR - Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Brancher JA; School of Health Sciences, UP - Universidade Positivo, Curitiba, Brazil.
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Źródło :
Brazilian dental journal [Braz Dent J] 2020 Sep-Oct; Vol. 31 (5), pp. 466-470.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium*
Estrogen Receptor alpha*/genetics
MicroRNAs*/genetics
Child ; Genetic Predisposition to Disease ; Humans ; Phosphorus ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Saliva
Czasopismo naukowe

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