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Wyszukujesz frazę ""Estrogen receptor"" wg kryterium: Temat


Tytuł :
Human Estrogen Receptor α Antagonists. Part 1: 3-D QSAR-Driven Rational Design of Innovative Coumarin-Related Antiestrogens as Breast Cancer Suppressants through Structure-Based and Ligand-Based Studies.
Autorzy :
Mihović N; Kragujevac Center for Computational Biochemistry, Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, P.O. Box 60, 34000 Kragujevac, Serbia.
Tomašević N; Kragujevac Center for Computational Biochemistry, Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, P.O. Box 60, 34000 Kragujevac, Serbia.
Matić S; Institute for Informational Technologies, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia.
Mitrović MM; Department of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 69, 34000 Kragujevac, Serbia.
Kostić DA; Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia.
Sabatino M; Rome Center for Molecular Design, Department of Drug Chemistry and Technology, Faculty of Pharmacy and Medicine, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
Antonini L; Rome Center for Molecular Design, Department of Drug Chemistry and Technology, Faculty of Pharmacy and Medicine, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
Ragno R; Rome Center for Molecular Design, Department of Drug Chemistry and Technology, Faculty of Pharmacy and Medicine, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
Mladenović M; Kragujevac Center for Computational Biochemistry, Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, P.O. Box 60, 34000 Kragujevac, Serbia.
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Źródło :
Journal of chemical information and modeling [J Chem Inf Model] 2021 Oct 25; Vol. 61 (10), pp. 5028-5053. Date of Electronic Publication: 2021 Oct 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms*/drug therapy
Estrogen Receptor alpha*
Coumarins ; Estradiol ; Estrogen Receptor Modulators ; Female ; Humans ; Ligands ; Quantitative Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The selective estrogen receptor modulator tamoxifen protects against subtle cognitive decline and early markers of injury 24 h after hippocampal silent infarct in male Sprague-Dawley rats.
Autorzy :
Finney CA; School of Medical Sciences, UNSW Sydney, Australia.
Shvetcov A; School of Psychology, UNSW Sydney, Australia.
Westbrook RF; School of Psychology, UNSW Sydney, Australia.
Morris MJ; School of Medical Sciences, UNSW Sydney, Australia.
Jones NM; School of Medical Sciences, UNSW Sydney, Australia. Electronic address: .
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Źródło :
Hormones and behavior [Horm Behav] 2021 Aug; Vol. 134, pp. 105016. Date of Electronic Publication: 2021 Jul 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cognitive Dysfunction*/drug therapy
Cognitive Dysfunction*/prevention & control
Selective Estrogen Receptor Modulators*/pharmacology
Animals ; Estradiol ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/metabolism ; Hippocampus/metabolism ; Infarction ; Male ; Rats ; Rats, Sprague-Dawley ; Tamoxifen/pharmacology
Czasopismo naukowe
Tytuł :
Revealing Adverse Outcome Pathways from Public High-Throughput Screening Data to Evaluate New Toxicants by a Knowledge-Based Deep Neural Network Approach.
Autorzy :
Ciallella HL; Center for Computational and Integrative Biology, Rutgers University Camden, Camden, New Jersey 08103, United States.
Russo DP; Center for Computational and Integrative Biology, Rutgers University Camden, Camden, New Jersey 08103, United States.; Department of Chemistry, Rutgers University Camden, Camden, New Jersey 08102, United States.
Aleksunes LM; Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey 08854, United States.
Grimm FA; ExxonMobil Biomedical Sciences, Inc., Annandale, New Jersey 08801, United States.
Zhu H; Center for Computational and Integrative Biology, Rutgers University Camden, Camden, New Jersey 08103, United States.; Department of Chemistry, Rutgers University Camden, Camden, New Jersey 08102, United States.
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Źródło :
Environmental science & technology [Environ Sci Technol] 2021 Aug 03; Vol. 55 (15), pp. 10875-10887. Date of Electronic Publication: 2021 Jul 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adverse Outcome Pathways*
Estrogen Receptor beta*
Estrogen Receptor alpha ; Estrogens ; High-Throughput Screening Assays ; Neural Networks, Computer
Czasopismo naukowe
Tytuł :
Physiologically Relevant Estrogen Receptor Alpha Pathway Reporters for Single-Cell Imaging-Based Carcinogenic Hazard Assessment of Estrogenic Compounds.
Autorzy :
Duijndam B; Division of Drug Discovery & Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden 2333CC, The Netherlands.; Section on Pharmacology, Toxicology and Kinetics, Medicines Evaluation Board, Utrecht 3531AH, The Netherlands.
Goudriaan A; Division of Drug Discovery & Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden 2333CC, The Netherlands.
van den Hoorn T; Section on Pharmacology, Toxicology and Kinetics, Medicines Evaluation Board, Utrecht 3531AH, The Netherlands.
van der Stel W; Division of Drug Discovery & Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden 2333CC, The Netherlands.
Le Dévédec S; Division of Drug Discovery & Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden 2333CC, The Netherlands.
Bouwman P; Division of Drug Discovery & Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden 2333CC, The Netherlands.
van der Laan JW; Section on Pharmacology, Toxicology and Kinetics, Medicines Evaluation Board, Utrecht 3531AH, The Netherlands.
van de Water B; Division of Drug Discovery & Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden 2333CC, The Netherlands.
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Źródło :
Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2021 May 27; Vol. 181 (2), pp. 187-198.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Estrogen Receptor alpha*/genetics
Estrogens*/toxicity
Carcinogens ; Cell Line, Tumor ; Estradiol/toxicity ; Estrogen Receptor beta ; Humans
Czasopismo naukowe
Tytuł :
Long-term oral administration of a novel estrogen receptor beta agonist enhances memory and alleviates drug-induced vasodilation in young ovariectomized mice.
Autorzy :
Fleischer AW; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, United States of America. Electronic address: .
Schalk JC; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, United States of America. Electronic address: .
Wetzel EA; Department of Chemistry, Marquette University, Milwaukee, WI 53201-1881, United States of America. Electronic address: .
Hanson AM; Department Pharmaceutical Sciences, Concordia University Wisconsin, Mequon, WI 53097, United States of America; Center for Structure-Based Drug Design and Development, Concordia University Wisconsin, Mequon, WI 53097, United States of America. Electronic address: .
Sem DS; Department Pharmaceutical Sciences, Concordia University Wisconsin, Mequon, WI 53097, United States of America; Center for Structure-Based Drug Design and Development, Concordia University Wisconsin, Mequon, WI 53097, United States of America. Electronic address: .
Donaldson WA; Department of Chemistry, Marquette University, Milwaukee, WI 53201-1881, United States of America. Electronic address: .
Frick KM; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, United States of America. Electronic address: .
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Źródło :
Hormones and behavior [Horm Behav] 2021 Apr; Vol. 130, pp. 104948. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Estrogen Receptor beta*
Pharmaceutical Preparations*
Administration, Oral ; Animals ; Estradiol/pharmacology ; Estrogen Receptor alpha ; Female ; Humans ; Mice ; Nitriles/pharmacology ; Ovariectomy ; Vasodilation
Czasopismo naukowe
Tytuł :
ER expression associates with poor prognosis in male lung squamous carcinoma after radical resection.
Autorzy :
Yang X; Department of Medical Oncology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China.
Jin X; Department of Thoracic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China.
Xu R; Department of Thoracic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China.
Yu Z; Department of Medical Oncology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China.
An N; Department of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China. .
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Źródło :
BMC cancer [BMC Cancer] 2021 Sep 21; Vol. 21 (1), pp. 1043. Date of Electronic Publication: 2021 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression*
Genes, Neoplasm*
Carcinoma, Squamous Cell/*genetics
Estrogen Receptor alpha/*genetics
Lung Neoplasms/*genetics
Aged ; Algorithms ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/surgery ; Databases, Genetic ; Disease-Free Survival ; Estrogen Receptor beta/genetics ; Genetic Markers ; Humans ; Immunohistochemistry ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Prognosis ; Receptors, Androgen/genetics
Czasopismo naukowe
Tytuł :
The evolving use of SERDs in estrogen receptor-positive, HER2-negative metastatic breast cancer.
Autorzy :
Jeselsohn RM; Breast Oncology Center, Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.
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Źródło :
Clinical advances in hematology & oncology : H&O [Clin Adv Hematol Oncol] 2021 Jul; Vol. 19 (7), pp. 428-431.
Typ publikacji :
Interview
MeSH Terms :
Antineoplastic Agents, Hormonal/*therapeutic use
Breast Neoplasms/*drug therapy
Receptor, ErbB-2/*analysis
Receptors, Estrogen/*analysis
Selective Estrogen Receptor Modulators/*therapeutic use
Breast Neoplasms/pathology ; Estrogen Receptor Antagonists/therapeutic use ; Female ; Fulvestrant/therapeutic use ; Humans ; Indoles/therapeutic use ; Neoplasm Metastasis/drug therapy ; Neoplasm Metastasis/pathology
Tytuł :
Biomimetic and estrogenic fibers promote tissue repair in mice and human skin via estrogen receptor β.
Autorzy :
Ahn S; Disease Biophysics Group, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
Chantre CO; Disease Biophysics Group, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
Ardoña HAM; Disease Biophysics Group, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
Gonzalez GM; Disease Biophysics Group, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
Campbell PH; Disease Biophysics Group, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
Parker KK; Disease Biophysics Group, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA. Electronic address: .
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Źródło :
Biomaterials [Biomaterials] 2020 Oct; Vol. 255, pp. 120149. Date of Electronic Publication: 2020 May 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Biomimetics*
Estrogen Receptor beta*
Animals ; Estrogen Receptor alpha ; Humans ; Mice ; Phytoestrogens ; Skin ; Wound Healing
Czasopismo naukowe
Tytuł :
Simvastatin mitigates depressive-like behavior in ovariectomized rats: Possible role of NLRP3 inflammasome and estrogen receptors' modulation.
Autorzy :
Menze ET; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Ezzat H; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Shawky S; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Sami M; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Selim EH; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Ahmed S; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Maged N; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Nadeem N; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Eldash S; Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Michel HE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address: .
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2021 Jun; Vol. 95, pp. 107582. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article
MeSH Terms :
Antidepressive Agents/*therapeutic use
Depression/*drug therapy
Estrogen Receptor Modulators/*therapeutic use
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
Simvastatin/*therapeutic use
Animals ; Antidepressive Agents/pharmacology ; Behavior, Animal/drug effects ; Depression/metabolism ; Estradiol/blood ; Estradiol/metabolism ; Estrogen Receptor Modulators/pharmacology ; Estrogen Receptor alpha/genetics ; Estrogen Receptor beta/genetics ; Female ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Inflammasomes/genetics ; Microglia/drug effects ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Ovariectomy ; Rats, Sprague-Dawley ; Simvastatin/pharmacology ; Uterus/drug effects ; Uterus/metabolism
Czasopismo naukowe
Tytuł :
Seasonal expressions of ERα, ERβ, EGF, EGFR, PI3K and Akt in the scent glands of the muskrats (Ondatra zibethicus).
Autorzy :
Xie W; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.
Zhao X; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.
Guo L; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.
Han Y; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.
Yuan Z; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.
Zhang H; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China. Electronic address: .
Weng Q; Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China. Electronic address: .
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2021 Oct; Vol. 213, pp. 105961. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Arvicolinae/*genetics
Epidermal Growth Factor/*genetics
ErbB Receptors/*genetics
Estrogen Receptor alpha/*genetics
Estrogen Receptor beta/*genetics
Phosphatidylinositol 3-Kinase/*genetics
Proto-Oncogene Proteins c-akt/*genetics
Animals ; Arvicolinae/metabolism ; China ; Epidermal Growth Factor/metabolism ; ErbB Receptors/metabolism ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/metabolism ; Gene Expression Regulation ; Male ; Phosphatidylinositol 3-Kinase/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Reproduction/genetics ; Scent Glands/metabolism ; Seasons ; Sex Attractants/biosynthesis ; Signal Transduction
Czasopismo naukowe
Tytuł :
Estrogen receptor α in mature osteoblasts regulates the late stage of bone regeneration.
Autorzy :
Ikedo A; Division of Integrative Pathophysiology, Proteo-Science Center, Ehime University, Ehime, Japan.
Imai Y; Division of Integrative Pathophysiology, Proteo-Science Center, Ehime University, Ehime, Japan; Department of Pathophysiology, Ehime University Graduate School of Medicine, Ehime, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jun 25; Vol. 559, pp. 238-244. Date of Electronic Publication: 2021 May 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Regeneration/*physiology
Estrogen Receptor alpha/*metabolism
Osteoblasts/*metabolism
Animals ; Bone and Bones/pathology ; Estrogen Receptor beta/metabolism ; Estrogens/deficiency ; Estrogens/metabolism ; Fracture Healing ; Mice, Knockout ; Organ Size ; Ovariectomy
Czasopismo naukowe
Tytuł :
Increased expression of thyroid hormone receptor alpha and estrogen receptor alpha in breast cancer associated with thyroid cancer.
Autorzy :
Kim YA; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, South Korea.
Kim YA; Department of Pathology, Seoul National University College of Medicine. Seoul, South Korea; Department of Pathology, Seoul National University Boramae Medical Center, Seoul, South Korea.
Cho SW; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Song YS; Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Min HS; Division of Public Healthcare Policy, National Medical Center, Seoul, South Korea; Department of Pathology, Seoul National University Hospital, Seoul, South Korea.
Park IA; Department of Pathology, Seoul National University College of Medicine. Seoul, South Korea; Department of Pathology, Seoul National University Hospital, Seoul, South Korea.
Park DJ; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Hwang KT; Department of Surgery, Seoul National University Boramae Medical Center, Seoul, South Korea.
Park YJ; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea. Electronic address: .
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Źródło :
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2021 Jun; Vol. 47 (6), pp. 1316-1323. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*metabolism
Estrogen Receptor alpha/*metabolism
Neoplasm Recurrence, Local/*metabolism
Neoplasms, Multiple Primary/*metabolism
Thyroid Hormone Receptors alpha/*metabolism
Thyroid Neoplasms/*pathology
Adult ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Estrogen Receptor beta/metabolism ; Female ; Humans ; Mammary Glands, Human/metabolism ; Middle Aged ; Neoplasm Staging ; Neoplasms, Multiple Primary/pathology ; Retrospective Studies ; Survival Rate ; Thyroid Hormone Receptors beta/metabolism ; Thyroid Neoplasms/radiotherapy ; Thyrotropin/blood ; Tissue Array Analysis
Czasopismo naukowe
Tytuł :
Estrogen Receptor β-Mediated Inhibition of Actin-Based Cell Migration Suppresses Metastasis of Inflammatory Breast Cancer.
Autorzy :
Thomas C; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. .
Karagounis IV; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Srivastava RK; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Vrettos N; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Nikolos F; Cedars-Sinai Medical Center, Los Angeles, California.
Francois N; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Huang M; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Gong S; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Long Q; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Kumar S; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Koumenis C; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Krishnamurthy S; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Ueno NT; Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Chakrabarti R; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Maity A; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. .
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Źródło :
Cancer research [Cancer Res] 2021 May 01; Vol. 81 (9), pp. 2399-2414. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Actins/*metabolism
Cell Movement/*genetics
Estrogen Receptor beta/*metabolism
Inflammatory Breast Neoplasms/*metabolism
Signal Transduction/*genetics
Actin Cytoskeleton/metabolism ; Animals ; Cohort Studies ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/genetics ; Female ; Gene Knockout Techniques ; HEK293 Cells ; Humans ; Inflammatory Breast Neoplasms/genetics ; Inflammatory Breast Neoplasms/pathology ; MCF-7 Cells ; Mice ; Neoplasm Metastasis/genetics ; Transfection ; Tumor Burden/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Methylation of ERβ 5'-untranslated region attenuates its inhibitory effect on ERα gene transcription and promotes the initiation and progression of papillary thyroid cancer.
Autorzy :
Xu LW; Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Gou X; Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Yang JY; Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Jiang R; Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Jiang X; Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Chen GG; Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
Liu ZM; Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Apr; Vol. 35 (4), pp. e21516.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Estrogen Receptor alpha/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Thyroid Cancer, Papillary/*genetics
Thyroid Neoplasms/*genetics
Cell Line, Tumor ; Down-Regulation ; Estrogen Receptor beta/genetics ; Estrogen Receptor beta/metabolism ; Humans ; Receptors, Estrogen/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Liuwei Dihuang formula protect endothelial cells from apoptosis by up-regulating expression of estrogen receptor-α.
Autorzy :
Chen Q; Collage of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Qi X; Collage of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.; Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Fu Y; Collage of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Ji T; Collage of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Chao Y; Collage of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Li J; Collage of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Meng Q; Collage of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Bian H; Collage of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, collage of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Li Y; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing 210023, China.
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Źródło :
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan [J Tradit Chin Med] 2021 Apr; Vol. 41 (2), pp. 227-235.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Cardiovascular Diseases/*drug therapy
Drugs, Chinese Herbal/*administration & dosage
Estrogen Receptor alpha/*metabolism
Human Umbilical Vein Endothelial Cells/*drug effects
Protective Agents/*administration & dosage
Animals ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/physiopathology ; Estrogen Receptor alpha/genetics ; Estrogen Receptor beta/genetics ; Estrogen Receptor beta/metabolism ; Female ; Human Umbilical Vein Endothelial Cells/cytology ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Hydrogen Peroxide/toxicity ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
[Mechanism of traditional Chinese medicine balancing Yin-Yang by targeting ERα/ERβ and its application in treatment of menopausal syndrome].
Autorzy :
Zhao PW; School of Life Science, Beijing University of Chinese Medicine Beijing 100029, China.
Wang YX; Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing 100700, China.
Niu JZ; School of Chinese Medicine, Beijing University of Chinese Medicine Beijing 100029, China.
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Źródło :
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2020 Aug; Vol. 45 (16), pp. 3770-3775.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Estrogen Receptor beta*
Yin-Yang*
Estrogen Receptor alpha ; Estrogens ; Female ; Humans ; Medicine, Chinese Traditional
Czasopismo naukowe
Tytuł :
Design and synthesis of novel benzothiophene analogs as selective estrogen receptor covalent antagonists against breast cancer.
Autorzy :
Bai C; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Ren S; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Wu S; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Zhu M; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Luo G; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China.
Xiang H; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 05; Vol. 221, pp. 113543. Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Antineoplastic Agents/*pharmacology
Breast Neoplasms/*drug therapy
Estrogen Receptor Antagonists/*pharmacology
Receptors, Estrogen/*antagonists & inhibitors
Thiophenes/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Estrogen Receptor Antagonists/chemical synthesis ; Estrogen Receptor Antagonists/chemistry ; Female ; Humans ; MCF-7 Cells ; Molecular Structure ; Receptors, Estrogen/metabolism ; Structure-Activity Relationship ; Thiophenes/chemical synthesis ; Thiophenes/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
In silico identification of novel inhibitors targeting the DNA-binding domain of the human estrogen receptor alpha.
Autorzy :
Cao H; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan, 430056, China.
Sun Y; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan, 430056, China.
Wang L; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan, 430056, China.
Pan Y; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan, 430056, China.
Li Z; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan, 430056, China.
Liang Y; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan, 430056, China. Electronic address: .
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Źródło :
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2021 Oct; Vol. 213, pp. 105966. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Response Elements*
Antineoplastic Agents/*pharmacology
DNA/*chemistry
Estrogen Antagonists/*pharmacology
Estrogen Receptor alpha/*chemistry
Neoplasm Proteins/*chemistry
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Binding Sites ; Cell Proliferation/drug effects ; DNA/metabolism ; Dose-Response Relationship, Drug ; Estrogen Antagonists/chemical synthesis ; Estrogen Antagonists/metabolism ; Estrogen Receptor alpha/antagonists & inhibitors ; Estrogen Receptor alpha/genetics ; Estrogen Receptor alpha/metabolism ; Female ; Humans ; Ligands ; MCF-7 Cells ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Nucleic Acid Conformation ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Structure-Activity Relationship ; Thermodynamics ; User-Computer Interface
Czasopismo naukowe
Tytuł :
Reduced menin expression leads to decreased ERα expression and is correlated with the occurrence of human luminal B-like and ER-negative breast cancer subtypes.
Autorzy :
Teinturier R; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.
Abou Ziki R; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.
Kassem L; Clinical Oncology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Luo Y; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.
Malbeteau L; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.
Gherardi S; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.
Corbo L; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.
Bertolino P; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.
Bachelot T; Department of Medical Oncology, Centre Léon Bérard, Lyon, France.
Treilleux I; Département de Biopathologie, Centre Léon Bérard, 69008, Lyon, France. .
Zhang CX; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France. .
Le Romancer M; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, 69008, Lyon, France.
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Źródło :
Breast cancer research and treatment [Breast Cancer Res Treat] 2021 Dec; Vol. 190 (3), pp. 389-401. Date of Electronic Publication: 2021 Sep 24.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*/genetics
Estrogen Receptor alpha*/genetics
Estrogen Receptor alpha*/metabolism
Animals ; Female ; Gene Expression Regulation, Neoplastic ; Hepatocyte Nuclear Factor 3-alpha ; Humans ; MCF-7 Cells ; Mice ; Promoter Regions, Genetic ; Proto-Oncogene Proteins/genetics
Czasopismo naukowe
Tytuł :
Triphenyl phosphate delayed pubertal timing and induced decline of ovarian reserve in mice as an estrogen receptor antagonist.
Autorzy :
Ma H; MOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China.
Ishida K; Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, Gifu, 501-1196, Japan.
Xu C; MOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China.
Takahashi K; Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, Gifu, 501-1196, Japan.
Li Y; MOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China.
Zhang C; MOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China.
Kang Q; MOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China.
Jia Y; MOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China.
Hu W; MOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China.
Matsumaru D; Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, Gifu, 501-1196, Japan.
Nakanishi T; Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, Gifu, 501-1196, Japan.
Hu J; MOE Laboratory for Earth Surface Process, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China. Electronic address: .
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Źródło :
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2021 Dec 01; Vol. 290, pp. 118096. Date of Electronic Publication: 2021 Sep 02.
Typ publikacji :
Journal Article
MeSH Terms :
Estrogen Receptor Antagonists*
Ovarian Reserve*
Animals ; Female ; Mice ; Mice, Inbred C57BL ; Organophosphates
Czasopismo naukowe

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