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Tytuł:
Metabolic benefits of 17α-estradiol in liver are partially mediated by ERβ in male mice.
Autorzy:
Mondal SA; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Chapman S212, Oklahoma City, OK, 73104, USA.
Mann SN; Department of Neuroscience, University of Arizona, Tucson, AZ, USA.
van der Linden C; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Chapman S212, Oklahoma City, OK, 73104, USA.
Sathiaseelan R; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Chapman S212, Oklahoma City, OK, 73104, USA.; Department of Nutritional Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Kamal M; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Das S; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Bubak MP; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Chapman S212, Oklahoma City, OK, 73104, USA.
Logan S; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Miller BF; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Chapman S212, Oklahoma City, OK, 73104, USA.; Oklahoma City Veterans Affairs Medical Center, Oklahoma City, OK, USA.
Stout MB; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Chapman S212, Oklahoma City, OK, 73104, USA. .; Oklahoma City Veterans Affairs Medical Center, Oklahoma City, OK, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jun 17; Vol. 13 (1), pp. 9841. Date of Electronic Publication: 2023 Jun 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
MeSH Terms:
Estradiol*/pharmacology
Estradiol*/metabolism
Estrogen Receptor beta*/genetics
Estrogen Receptor beta*/metabolism
Mice ; Female ; Animals ; Hepatocytes/metabolism ; Liver Cirrhosis/pathology ; Hepatic Stellate Cells/metabolism ; Fibrosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Membrane estrogen receptor α signaling modulates the sensitivity to estradiol treatment in a dose- and tissue- dependent manner.
Autorzy:
Jiang Y; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Vita Stråket 11, S-413 45, Göteborg, Sweden.
Horkeby K; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Vita Stråket 11, S-413 45, Göteborg, Sweden. .
Henning P; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Vita Stråket 11, S-413 45, Göteborg, Sweden.
Wu J; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Vita Stråket 11, S-413 45, Göteborg, Sweden.
Lawenius L; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Vita Stråket 11, S-413 45, Göteborg, Sweden.
Engdahl C; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Vita Stråket 11, S-413 45, Göteborg, Sweden.; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Gupta P; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Vita Stråket 11, S-413 45, Göteborg, Sweden.; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Movérare-Skrtic S; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Vita Stråket 11, S-413 45, Göteborg, Sweden.
Nilsson KH; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Vita Stråket 11, S-413 45, Göteborg, Sweden.
Levin E; Division of Endocrinology, Department of Medicine, University of California, Irvine, Irvine, CA, 92697, USA.; Department of Veterans Affairs Medical Center, Long Beach, Long Beach, CA, 90822, USA.
Ohlsson C; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Vita Stråket 11, S-413 45, Göteborg, Sweden.; Department of Drug Treatment, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden.
Lagerquist MK; Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Vita Stråket 11, S-413 45, Göteborg, Sweden.
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Źródło:
Scientific reports [Sci Rep] 2023 Jun 03; Vol. 13 (1), pp. 9046. Date of Electronic Publication: 2023 Jun 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Estrogen Receptor alpha*/genetics
Estradiol*/pharmacology
Female ; Mice ; Animals ; Humans ; Bone and Bones ; Signal Transduction ; Bone Density ; Uterus ; Ovariectomy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Patterns of sex hormone receptor expression in stimulated endometrium from oocyte donors.
Autorzy:
Manvelyan E; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, USA.; Department of Obstetrics & Gynecology, Donald and Barbara Zucker School of Medicine at Hofstra, South Shore University Hospital, Northwell Health, NY, USA.
Houshdaran S; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, USA.
Irwin JC; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, USA.
Giudice LC; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, USA.
Aghajanova L; Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, USA.; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA.
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Źródło:
Human fertility (Cambridge, England) [Hum Fertil (Camb)] 2022 Oct; Vol. 25 (4), pp. 662-669. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Estrogen Receptor alpha*/metabolism
Estradiol*
Female ; Humans ; Endometrium/metabolism ; Receptors, Progesterone/metabolism ; Progesterone ; Oocytes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Puberty enables oestradiol-induced progesterone synthesis in female mouse hypothalamic astrocytes.
Autorzy:
Mohr MA; Department of Neurobiology, UCLA DGSOM, Los Angeles, California, USA.; Laboratory of Neuroendocrinology, Brain Research Institute, University of California Los Angeles, Los Angeles, California, USA.
Keshishian T; Department of Neurobiology, UCLA DGSOM, Los Angeles, California, USA.; Laboratory of Neuroendocrinology, Brain Research Institute, University of California Los Angeles, Los Angeles, California, USA.
Falcy BA; Department of Neuroscience and Behavior, University of Massachusetts, Amherst, Massachusetts, USA.
Laham BJ; Department of Psychology, Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA.
Wong AM; Department of Neurobiology, UCLA DGSOM, Los Angeles, California, USA.; Laboratory of Neuroendocrinology, Brain Research Institute, University of California Los Angeles, Los Angeles, California, USA.
Micevych PE; Department of Neurobiology, UCLA DGSOM, Los Angeles, California, USA.; Laboratory of Neuroendocrinology, Brain Research Institute, University of California Los Angeles, Los Angeles, California, USA.
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Źródło:
Journal of neuroendocrinology [J Neuroendocrinol] 2022 Jun; Vol. 34 (6), pp. e13082. Date of Electronic Publication: 2022 Jan 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Estradiol*/physiology
Estrogen Receptor alpha*/metabolism
Animals ; Astrocytes/metabolism ; Estrogens/metabolism ; Female ; Hypothalamus/metabolism ; Mice ; Progesterone/metabolism ; Rats ; Sexual Maturation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Nicotine sensitization (part 1): estradiol or tamoxifen is required during the induction phase and not the expression phase to enable locomotor sensitization to nicotine in female rats.
Autorzy:
Baumbach JL; Department of Psychology, Centre for Neuroscience, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Ontario, L2S 3A1, Canada.
McCormick CM; Department of Psychology, Centre for Neuroscience, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Ontario, L2S 3A1, Canada. .
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2021 Feb; Vol. 238 (2), pp. 355-370. Date of Electronic Publication: 2020 Nov 01.
Typ publikacji:
Journal Article
MeSH Terms:
Estradiol/*pharmacology
Locomotion/*drug effects
Nicotine/*pharmacology
Receptors, Estrogen/*metabolism
Selective Estrogen Receptor Modulators/*pharmacology
Tamoxifen/*pharmacology
Animals ; Behavior, Animal/drug effects ; Estrogen Receptor alpha/agonists ; Estrogen Receptor beta/agonists ; Female ; Humans ; Ovariectomy ; Rats ; Rats, Long-Evans ; Receptors, G-Protein-Coupled/agonists ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Challenging Approach to the Development of Novel Estrogen Receptor Modulators Based on the Chemical Properties of Guaiazulene.
Autorzy:
Ohta K; School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
Kaise A; Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
Ogawa T; Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
Endo Y; Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 20; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 20.
Typ publikacji:
Journal Article
MeSH Terms:
Azulenes/*chemical synthesis
Breast Neoplasms/*metabolism
Estradiol/*pharmacology
Estrogen Receptor Modulators/*chemical synthesis
Receptors, Estrogen/*metabolism
Sesquiterpenes, Guaiane/*chemistry
Azulenes/chemistry ; Azulenes/pharmacology ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Development ; Drug Synergism ; Estrogen Receptor Modulators/chemistry ; Estrogen Receptor Modulators/pharmacology ; Female ; Humans ; MCF-7 Cells ; Models, Molecular ; Molecular Structure ; Protein Binding ; Protein Conformation ; Receptors, Estrogen/chemistry ; Tamoxifen/analogs & derivatives ; Tamoxifen/chemistry ; Tamoxifen/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Elucidation of Agonist and Antagonist Dynamic Binding Patterns in ER-α by Integration of Molecular Docking, Molecular Dynamics Simulations and Quantum Mechanical Calculations.
Autorzy:
Sakkiah S; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
Selvaraj C; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
Guo W; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
Liu J; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
Ge W; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
Patterson TA; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
Hong H; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 29; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 29.
Typ publikacji:
Journal Article
MeSH Terms:
Estradiol/*metabolism
Estrogen Receptor alpha/*agonists
Estrogen Receptor alpha/*antagonists & inhibitors
Estrogen Receptor alpha/*metabolism
Tamoxifen/*analogs & derivatives
Estradiol/chemistry ; Estrogen Receptor alpha/chemistry ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Quantum Theory ; Tamoxifen/chemistry ; Tamoxifen/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Inhibitory effect of 17β‑estradiol on triglyceride synthesis in skeletal muscle cells is dependent on ESR1 and not ESR2.
Autorzy:
Liu Q; Department of Clinical Pharmacy, Class 2014, School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Li R; Department of Clinical Pharmacy, Class 2014, School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Chen G; Center of Scientific Research, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Wang J; Dalian Maple International School, Dalian, Liaoning 116100, P.R. China.
Hu B; Department of Clinical Pharmacy, Class 2014, School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Li C; The Comprehensive Laboratory, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Zhu X; Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China.
Lu Y; The Comprehensive Laboratory, Anhui Medical University, Hefei, Anhui 230032, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2019 Jun; Vol. 19 (6), pp. 5087-5096. Date of Electronic Publication: 2019 Apr 24.
Typ publikacji:
Journal Article
MeSH Terms:
Estradiol/*pharmacology
Estrogen Receptor alpha/*metabolism
Triglycerides/*biosynthesis
Animals ; Cell Line ; Down-Regulation/drug effects ; Estrogen Receptor alpha/agonists ; Estrogen Receptor alpha/genetics ; Estrogen Receptor beta/genetics ; Estrogen Receptor beta/metabolism ; Fatty Acid Synthases/genetics ; Fatty Acid Synthases/metabolism ; Female ; Insulin Resistance ; Mice ; Muscle, Skeletal/cytology ; Muscle, Skeletal/metabolism ; Ovariectomy ; Palmitic Acid/pharmacology ; Perilipin-2/genetics ; Perilipin-2/metabolism ; Phenols/pharmacology ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Pyrazoles/pharmacology ; Rats ; Rats, Sprague-Dawley ; Up-Regulation/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Estrogen Receptors Alpha and Beta Mediate Synaptic Transmission in the PFC and Hippocampus of Mice.
Autorzy:
Zhang M; Lab for Molecular Neuroscience, Clinic for Mental Health, University Hospital Muenster, 48149 Muenster, Germany.
Weiland H; Lab for Molecular Neuroscience, Clinic for Mental Health, University Hospital Muenster, 48149 Muenster, Germany.
Schöfbänker M; Lab for Molecular Neuroscience, Clinic for Mental Health, University Hospital Muenster, 48149 Muenster, Germany.
Zhang W; Lab for Molecular Neuroscience, Clinic for Mental Health, University Hospital Muenster, 48149 Muenster, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 02; Vol. 22 (3). Date of Electronic Publication: 2021 Feb 02.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Estradiol/*pharmacology
Estrogen Receptor alpha/*physiology
Hippocampus/*metabolism
Prefrontal Cortex/*metabolism
Synaptic Transmission/*physiology
Animals ; Estrogen Receptor alpha/agonists ; Excitatory Amino Acid Agents/pharmacology ; Excitatory Postsynaptic Potentials/drug effects ; Female ; GABA Agents/pharmacology ; Hippocampus/drug effects ; Inhibitory Postsynaptic Potentials/drug effects ; Kinetics ; Male ; Mice ; Mice, Inbred C57BL ; Nitriles/pharmacology ; Patch-Clamp Techniques ; Prefrontal Cortex/drug effects ; Propionates/pharmacology ; Sex Characteristics ; Synaptic Transmission/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Advantages in Wound Healing Process in Female Mice Require Upregulation A 2A -Mediated Angiogenesis under the Stimulation of 17β-Estradiol.
Autorzy:
Troncoso F; Vascular Physiology Laboratory, Department of Basic Sciences, Universidad del Bío-Bío, 3780000 Chillán, Chile.; Programa de Doctorado en Ciencias Veterinarias, Universidad de Concepción, 3780000 Chillán, Chile.
Herlitz K; Vascular Physiology Laboratory, Department of Basic Sciences, Universidad del Bío-Bío, 3780000 Chillán, Chile.
Acurio J; Vascular Physiology Laboratory, Department of Basic Sciences, Universidad del Bío-Bío, 3780000 Chillán, Chile.; Group of Research and Innovation in Vascular Health (GRIVAS Health), 3780000 Chillán, Chile.
Aguayo C; Group of Research and Innovation in Vascular Health (GRIVAS Health), 3780000 Chillán, Chile.; Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, 4030000 Concepción, Chile.
Guevara K; Vascular Physiology Laboratory, Department of Basic Sciences, Universidad del Bío-Bío, 3780000 Chillán, Chile.
Castro FO; Department of Animal Science, Faculty of Veterinary Sciences, Universidad de Concepcion, 3780000 Chillán, Chile.
Godoy AS; Group of Research and Innovation in Vascular Health (GRIVAS Health), 3780000 Chillán, Chile.; Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Centro de Biología Celular y Biomedicina (CEBICEM), Universidad San Sebastián, 8320000 Santiago, Chile.
San Martin S; Group of Research and Innovation in Vascular Health (GRIVAS Health), 3780000 Chillán, Chile.; Biomedical Research Centre, School of Medicine, Universidad de Valparaíso, 2340000 Valparaíso, Chile.
Escudero C; Vascular Physiology Laboratory, Department of Basic Sciences, Universidad del Bío-Bío, 3780000 Chillán, Chile.; Group of Research and Innovation in Vascular Health (GRIVAS Health), 3780000 Chillán, Chile.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 28; Vol. 21 (19). Date of Electronic Publication: 2020 Sep 28.
Typ publikacji:
Journal Article
MeSH Terms:
Estradiol/*pharmacology
Estrogen Receptor alpha/*genetics
Estrogen Receptor beta/*genetics
Neovascularization, Physiologic/*drug effects
Receptor, Adenosine A2A/*genetics
Wounds, Penetrating/*genetics
Adenosine/analogs & derivatives ; Adenosine/pharmacology ; Animals ; Cell Proliferation/drug effects ; Endothelial Cells/cytology ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Estrogen Receptor alpha/antagonists & inhibitors ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/antagonists & inhibitors ; Estrogen Receptor beta/metabolism ; Female ; Gene Expression Regulation ; Lung/cytology ; Lung/metabolism ; Male ; Mice ; Mice, Knockout ; Neovascularization, Physiologic/genetics ; Phenethylamines/pharmacology ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; Receptor Cross-Talk ; Receptor, Adenosine A2A/metabolism ; Sex Factors ; Signal Transduction ; Wound Healing/drug effects ; Wound Healing/genetics ; Wounds, Penetrating/drug therapy ; Wounds, Penetrating/metabolism ; Wounds, Penetrating/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Estrogen rescues heart failure through estrogen receptor Beta activation.
Autorzy:
Iorga A; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.; Present address: Department of Medicine, Division of Gastroenterology/Liver, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Umar S; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.
Ruffenach G; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.
Aryan L; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.
Li J; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.
Sharma S; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.
Motayagheni N; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.; Present Address: Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston-Salem, NC 27109, USA.
Nadadur RD; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.
Bopassa JC; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA.; Present address: Department of Physiology, University of Texas Health Science Center, San Antonio, TX, 78229, USA.
Eghbali M; Department of Anesthesiology, Division of Molecular Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 90095, USA. .
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Źródło:
Biology of sex differences [Biol Sex Differ] 2018 Oct 30; Vol. 9 (1), pp. 48. Date of Electronic Publication: 2018 Oct 30.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Estradiol/*therapeutic use
Estrogen Receptor beta/*physiology
Estrogens/*therapeutic use
Heart Failure/*drug therapy
Animals ; Cells, Cultured ; Coculture Techniques ; Estradiol/pharmacology ; Estrogen Receptor alpha/agonists ; Estrogen Receptor alpha/physiology ; Estrogen Receptor beta/agonists ; Estrogen Receptor beta/antagonists & inhibitors ; Estrogens/pharmacology ; Heart/drug effects ; Heart/physiology ; Heart Failure/physiopathology ; Male ; Mice ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Oestradiol acts through its beta receptor to increase vasopressin neuronal activation and secretion induced by dehydration.
Autorzy:
Vilhena-Franco T; Department of Physiology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.
Mecawi AS; Department of Biophysics, Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil.
Almeida-Pereira G; Department of Physiology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.
Lucio-Oliveira F; Federal Institute of Education, Science and Technology of Southern Minas Gerais, Muzambinho, Brazil.
Elias LLK; Department of Physiology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.
Antunes-Rodrigues J; Department of Physiology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.
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Źródło:
Journal of neuroendocrinology [J Neuroendocrinol] 2019 Apr; Vol. 31 (4), pp. e12712. Date of Electronic Publication: 2019 Apr 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Estradiol/*pharmacology
Estrogen Receptor beta/*physiology
Neurons/*physiology
Vasopressins/*physiology
Water Deprivation/*physiology
Animals ; Estrogen Receptor alpha/agonists ; Estrogen Receptor alpha/physiology ; Estrogen Receptor beta/agonists ; Estrogen Receptor beta/antagonists & inhibitors ; Female ; Osmolar Concentration ; Paraventricular Hypothalamic Nucleus/chemistry ; Paraventricular Hypothalamic Nucleus/metabolism ; RNA, Messenger/analysis ; Rats ; Rats, Wistar ; Silicone Elastomers ; Supraoptic Nucleus/chemistry ; Supraoptic Nucleus/metabolism ; TRPV Cation Channels/genetics ; TRPV Cation Channels/physiology ; Vasopressins/analysis ; Vasopressins/blood
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Elucidating Binding Sites and Affinities of ERα Agonists and Antagonists to Human Alpha-Fetoprotein by In Silico Modeling and Point Mutagenesis.
Autorzy:
Moldogazieva NT; Laboratory of Bioinformatics, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Ostroverkhova DS; Laboratory of Bioinformatics, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.; Department of Bioengineering, M.V. Lomonosov Moscow State University, 119991 Moscow, Russia.
Kuzmich NN; Laboratory of Bioinformatics, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.; Department of Drug Safety, I.M. Smorodintsev Research Institute of Influenza, WHO National Influenza Centre of Russia, 197376 Saint Petersburg, Russia.
Kadochnikov VV; Department of Food Biotechnology and Engineering, Saint Petersburg National Research University of Information Technologies, Mechanics and Optics, 197101 Saint-Petersburg, Russia.
Terentiev AA; Deparment of Biochemistry and Molecular Biology, N.I. Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Porozov YB; Laboratory of Bioinformatics, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.; Department of Food Biotechnology and Engineering, Saint Petersburg National Research University of Information Technologies, Mechanics and Optics, 197101 Saint-Petersburg, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 30; Vol. 21 (3). Date of Electronic Publication: 2020 Jan 30.
Typ publikacji:
Journal Article
MeSH Terms:
Estradiol/*metabolism
Estrogen Receptor Modulators/*metabolism
Estrogen Receptor alpha/*metabolism
Estrogens/*metabolism
alpha-Fetoproteins/*metabolism
Amino Acid Sequence ; Amino Acid Substitution ; Binding Sites ; Estrogen Receptor alpha/agonists ; Estrogen Receptor alpha/antagonists & inhibitors ; Female ; Humans ; Ligands ; Models, Molecular ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Mutagenesis ; Sequence Alignment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Unexpected Impact of a Hepatitis C Virus Inhibitor on 17β-Estradiol Signaling in Breast Cancer.
Autorzy:
Bartoloni S; Department of Sciences, Section Biomedical Sciences and Technology, University Roma Tre, Viale Guglielmo Marconi, 446, I-00146 Rome, Italy.
Leone S; Department of Sciences, Section Biomedical Sciences and Technology, University Roma Tre, Viale Guglielmo Marconi, 446, I-00146 Rome, Italy.
Acconcia F; Department of Sciences, Section Biomedical Sciences and Technology, University Roma Tre, Viale Guglielmo Marconi, 446, I-00146 Rome, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 May 12; Vol. 21 (10). Date of Electronic Publication: 2020 May 12.
Typ publikacji:
Journal Article
MeSH Terms:
Estradiol/*pharmacology
Estrogen Receptor alpha/*metabolism
Hepacivirus/*drug effects
Oligopeptides/*pharmacology
Signal Transduction/*drug effects
Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Estrogen Receptor alpha/genetics ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Hepacivirus/metabolism ; Humans ; MCF-7 Cells ; Molecular Structure ; Oligopeptides/chemistry ; Serine Proteases/metabolism ; Signal Transduction/genetics ; Viral Nonstructural Proteins/antagonists & inhibitors ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Estradiol Regulates mRNA Levels of Estrogen Receptor Beta 4 and Beta 5 Isoforms and Modulates Human Granulosa Cell Apoptosis.
Autorzy:
Pierre A; BFA, UMR 8251, CNRS, ERL U1133, Inserm, Université de Paris, F-75013 Paris, France.
Mayeur A; Service de Médecine de la Reproduction et Préservation de la Fertilité, Hôpital Antoine Béclère, 92140 Clamart, France.
Marie C; BFA, UMR 8251, CNRS, ERL U1133, Inserm, Université de Paris, F-75013 Paris, France.
Cluzet V; BFA, UMR 8251, CNRS, ERL U1133, Inserm, Université de Paris, F-75013 Paris, France.
Chauvin J; Lixoft, 8 rue de la Renaissance, Bâtiment D, 92160 Antony, France.
Frydman N; Service de Médecine de la Reproduction et Préservation de la Fertilité, Hôpital Antoine Béclère, 92140 Clamart, France.
Grynberg M; BFA, UMR 8251, CNRS, ERL U1133, Inserm, Université de Paris, F-75013 Paris, France.; Service de Médecine de la Reproduction et Préservation de la Fertilité, Hôpital Antoine Béclère, 92140 Clamart, France.
Cohen-Tannoudji J; BFA, UMR 8251, CNRS, ERL U1133, Inserm, Université de Paris, F-75013 Paris, France.
Guigon CJ; BFA, UMR 8251, CNRS, ERL U1133, Inserm, Université de Paris, F-75013 Paris, France.
Chauvin S; BFA, UMR 8251, CNRS, ERL U1133, Inserm, Université de Paris, F-75013 Paris, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 May 10; Vol. 22 (9). Date of Electronic Publication: 2021 May 10.
Typ publikacji:
Journal Article
MeSH Terms:
Estradiol/*pharmacology
Estrogen Receptor alpha/*genetics
Estrogen Receptor beta/*genetics
Granulosa Cells/*drug effects
Apoptosis/drug effects ; Female ; Gene Expression Regulation, Developmental/drug effects ; Humans ; Ovary/drug effects ; Protein Isoforms/genetics ; RNA, Messenger/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
RNA-sequencing of AVPV and ARH reveals vastly different temporal and transcriptomic responses to estradiol in the female rat hypothalamus.
Autorzy:
Mohr MA; Dept of Neurobiology, and the Laboratory of Neuroendocrinology of the Brain Research Institute, UCLA DGSOM, Los Angeles, California, United States of America.
Wong AM; Dept of Neurobiology, and the Laboratory of Neuroendocrinology of the Brain Research Institute, UCLA DGSOM, Los Angeles, California, United States of America.
Sukumar G; Dept of Gynecological Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.
Dalgard CL; Dept of Gynecological Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.
Hong W; Dept of Neurobiology, and the Laboratory of Neuroendocrinology of the Brain Research Institute, UCLA DGSOM, Los Angeles, California, United States of America.
Wu TJ; Dept of Gynecological Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.
Wu YE; Dept of Neurobiology, and the Laboratory of Neuroendocrinology of the Brain Research Institute, UCLA DGSOM, Los Angeles, California, United States of America.
Micevych PE; Dept of Neurobiology, and the Laboratory of Neuroendocrinology of the Brain Research Institute, UCLA DGSOM, Los Angeles, California, United States of America.
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Źródło:
PloS one [PLoS One] 2021 Aug 18; Vol. 16 (8), pp. e0256148. Date of Electronic Publication: 2021 Aug 18 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Arcuate Nucleus of Hypothalamus/*metabolism
Estradiol/*pharmacology
Gene Expression Regulation/*drug effects
Gonadotropin-Releasing Hormone/*metabolism
Hypothalamus/*metabolism
Hypothalamus, Anterior/*metabolism
Sequence Analysis, RNA/*methods
Animals ; Arcuate Nucleus of Hypothalamus/drug effects ; Estrogen Receptor alpha/metabolism ; Estrogens/pharmacology ; Female ; Hypothalamus/drug effects ; Hypothalamus, Anterior/drug effects ; Kisspeptins/metabolism ; Models, Animal ; Ovariectomy/methods ; Rats ; Rats, Long-Evans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Estrogen Receptors: Therapeutic Perspectives for the Treatment of Cardiac Dysfunction after Myocardial Infarction.
Autorzy:
da Silva JS; Programa de Pesquisa em Desenvolvimento de Fármacos, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Montagnoli TL; Programa de Pesquisa em Desenvolvimento de Fármacos, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Rocha BS; Programa de Pesquisa em Desenvolvimento de Fármacos, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Tacco MLCA; Programa de Pesquisa em Desenvolvimento de Fármacos, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Marinho SCP; Programa de Pesquisa em Desenvolvimento de Fármacos, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Zapata-Sudo G; Programa de Pesquisa em Desenvolvimento de Fármacos, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.; Instituto de Cardiologia Edson Saad, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 07; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 07.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Estradiol/*therapeutic use
Estrogen Receptor alpha/*genetics
Estrogen Receptor beta/*genetics
Myocardial Infarction/*drug therapy
Animals ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Estrogens/genetics ; Estrogens/metabolism ; Female ; Humans ; Myocardial Infarction/genetics ; Myocardial Infarction/pathology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Receptors, Estrogen/genetics ; Receptors, G-Protein-Coupled/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Estrogen modulates epithelial progenitor cells in rat vagina.
Autorzy:
Chung HS; Department of Urology, Chonnam National University Medical School, Gwangju, Korea.
Lee HS; Department of Urology, Chonnam National University Medical School, Gwangju, Korea.
Park K; Department of Urology, Chonnam National University Medical School, Gwangju, Korea. .
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Źródło:
Investigative and clinical urology [Investig Clin Urol] 2021 May; Vol. 62 (3), pp. 349-353. Date of Electronic Publication: 2021 Apr 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial Cells/*drug effects
Estradiol/*pharmacology
Estrogens/*pharmacology
Stem Cells/*drug effects
Vagina/*drug effects
Vagina/*pathology
Animals ; Epithelial Cells/metabolism ; Estrogen Receptor alpha/metabolism ; Female ; Hyaluronan Receptors/metabolism ; Models, Animal ; Mucous Membrane/drug effects ; Mucous Membrane/metabolism ; Mucous Membrane/pathology ; Ovariectomy ; Rats ; Rats, Sprague-Dawley ; Receptors, Progesterone/metabolism ; Stem Cells/metabolism ; Vagina/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
17β-Estradiol and/or estrogen receptor alpha signaling blocks protein phosphatase 1 mediated ISO induced cardiac hypertrophy.
Autorzy:
Fang HY; Department of Thoracic Surgery, China Medical University Hospital, Taichung, Taiwan.
Hung MY; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
Lin YM; Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan.; Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan.
Pandey S; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
Chang CC; Department of Dermatology, Taipei City Hospital, Renai Branch, Taipei, Taiwan.
Lin KH; Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan.
Shen CY; Department of Nursing, Meiho University, Pingtung, Taiwan.
Viswanadha VP; Department of Biotechnology, Bharathiar University, Coimbatore, India.
Kuo WW; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.
Huang CY; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.; Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan.; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
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Źródło:
PloS one [PLoS One] 2018 May 03; Vol. 13 (5), pp. e0196569. Date of Electronic Publication: 2018 May 03 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cardiomegaly/*chemically induced
Cardiomegaly/*metabolism
Estradiol/*metabolism
Estrogen Receptor alpha/*metabolism
Isoproterenol/*toxicity
Protein Phosphatase 1/*metabolism
Animals ; Calcium/metabolism ; Cardiomegaly/prevention & control ; Cell Enlargement/drug effects ; Cell Line ; Estradiol/pharmacology ; Estrogen Receptor alpha/antagonists & inhibitors ; Models, Cardiovascular ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Rats ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Methyl palmitate reversed estradiol benzoate-induced endometrial hyperplasia in female rats.
Autorzy:
Olowofolahan AO; Laboratory for Membrane Biochemistry Research and Biotechnology, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Oyebode OT; Laboratory for Membrane Biochemistry Research and Biotechnology, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Olorunsogo OO; Laboratory for Membrane Biochemistry Research and Biotechnology, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
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Źródło:
Toxicology mechanisms and methods [Toxicol Mech Methods] 2021 Jan; Vol. 31 (1), pp. 43-52. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Inflammatory Agents/*pharmacology
Antioxidants/*pharmacology
Cell Proliferation/*drug effects
Endometrial Hyperplasia/*prevention & control
Endometrium/*drug effects
Estradiol/*analogs & derivatives
Mitochondria/*drug effects
Palmitates/*pharmacology
Animals ; Cytochromes c/metabolism ; Endometrial Hyperplasia/chemically induced ; Endometrial Hyperplasia/metabolism ; Endometrial Hyperplasia/pathology ; Endometrium/metabolism ; Endometrium/pathology ; Estradiol/toxicity ; Estrogen Receptor alpha/metabolism ; Female ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Interleukin-1beta/metabolism ; Lipid Peroxidation/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Proton-Translocating ATPases/metabolism ; Oxidative Stress/drug effects ; Rats, Wistar ; Signal Transduction ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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