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Wyszukujesz frazę ""Evans, Richard J."" wg kryterium: Autor


Tytuł :
Identification of a distinct desensitisation gate in the ATP-gated P2X2 receptor.
Autorzy :
Stavrou A; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, United Kingdom. Electronic address: .
Evans RJ; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, United Kingdom. Electronic address: .
Schmid R; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, United Kingdom; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 7RH, United Kingdom. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Feb 26; Vol. 523 (1), pp. 190-195. Date of Electronic Publication: 2019 Dec 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine Triphosphate/*metabolism
Receptors, Purinergic P2X2/*chemistry
Receptors, Purinergic P2X2/*metabolism
Humans ; Models, Molecular ; Mutation ; Receptors, Purinergic P2X2/genetics
Czasopismo naukowe
Tytuł :
P2X1 ion channel deficiency causes massive bleeding in inflamed intestine and increases thrombosis.
Autorzy :
Wéra O; GIGA Cardiovascular Sciences, Laboratory of Thrombosis and Hemostasis and Valvular Heart Diseases, University of Liège, Liège, Belgium.; Department of Cardiology, University Hospital of Liège, Liège, Belgium.
Lecut C; Department of Laboratory of Hematology, University Hospital of Liège, Liège, Belgium.
Servais L; GIGA Cardiovascular Sciences, Laboratory of Thrombosis and Hemostasis and Valvular Heart Diseases, University of Liège, Liège, Belgium.; Department of Cardiology, University Hospital of Liège, Liège, Belgium.
Hego A; GIGA Cardiovascular Sciences, Laboratory of Thrombosis and Hemostasis and Valvular Heart Diseases, University of Liège, Liège, Belgium.; Department of Cardiology, University Hospital of Liège, Liège, Belgium.
Delierneux C; GIGA Cardiovascular Sciences, Laboratory of Thrombosis and Hemostasis and Valvular Heart Diseases, University of Liège, Liège, Belgium.; Department of Cardiology, University Hospital of Liège, Liège, Belgium.
Jiang Z; GIGA Cardiovascular Sciences, Laboratory of Thrombosis and Hemostasis and Valvular Heart Diseases, University of Liège, Liège, Belgium.; Department of Cardiology, University Hospital of Liège, Liège, Belgium.
Keutgens A; Department of Laboratory of Hematology, University Hospital of Liège, Liège, Belgium.
Evans RJ; Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, UK.
Delvenne P; Department of Pathology, University Hospital of Liège, Liège, Belgium.
Lancellotti P; GIGA Cardiovascular Sciences, Laboratory of Thrombosis and Hemostasis and Valvular Heart Diseases, University of Liège, Liège, Belgium.; Gruppo Villa Maria Care and Research, Anthea Hospital, Bari, Italy.
Oury C; GIGA Cardiovascular Sciences, Laboratory of Thrombosis and Hemostasis and Valvular Heart Diseases, University of Liège, Liège, Belgium.; Department of Cardiology, University Hospital of Liège, Liège, Belgium.
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Źródło :
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2020 Jan; Vol. 18 (1), pp. 44-56. Date of Electronic Publication: 2019 Sep 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hemorrhage*/chemically induced
Receptors, Purinergic P2X1*
Thrombosis*
Intestines/*physiopathology
Animals ; Blood Platelets ; Mice
Czasopismo naukowe
Tytuł :
Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket.
Autorzy :
Bin Dayel A; Department of Molecular and Cell Biology (A.B.D., R.J.E., R.S.) and Leicester Institute of Structural and Chemical Biology (R.S.), University of Leicester, Leicester, United Kingdom.
Evans RJ; Department of Molecular and Cell Biology (A.B.D., R.J.E., R.S.) and Leicester Institute of Structural and Chemical Biology (R.S.), University of Leicester, Leicester, United Kingdom.
Schmid R; Department of Molecular and Cell Biology (A.B.D., R.J.E., R.S.) and Leicester Institute of Structural and Chemical Biology (R.S.), University of Leicester, Leicester, United Kingdom .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2019 Sep; Vol. 96 (3), pp. 355-363. Date of Electronic Publication: 2019 Jul 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Point Mutation*
Purinergic P2X Receptor Antagonists/*pharmacology
Receptors, Purinergic P2X7/*chemistry
Receptors, Purinergic P2X7/*metabolism
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives ; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/chemistry ; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology ; Adenosine Triphosphate/metabolism ; Allosteric Site ; Amides/chemistry ; Amides/pharmacology ; Binding Sites ; Humans ; Imidazoles/chemistry ; Imidazoles/pharmacology ; Indoles/chemistry ; Indoles/pharmacology ; Models, Molecular ; Molecular Docking Simulation ; Purinergic P2X Receptor Antagonists/chemistry ; Receptors, Purinergic P2X7/genetics ; Rosaniline Dyes/chemistry ; Rosaniline Dyes/pharmacology ; Thiazoles/chemistry ; Thiazoles/pharmacology
Czasopismo naukowe
Tytuł :
Development of a P2X1-eYFP receptor knock-in mouse to track receptors in real time.
Autorzy :
Mahaut Smith MP; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK.
Evans RJ; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK.
Vial C; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK. .
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Źródło :
Purinergic signalling [Purinergic Signal] 2019 Sep; Vol. 15 (3), pp. 397-402. Date of Electronic Publication: 2019 Jul 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Knock-In Techniques/*methods
Receptors, Purinergic P2X1/*analysis
Receptors, Purinergic P2X1/*metabolism
Animals ; Bacterial Proteins ; Luminescent Proteins ; Mice ; Models, Animal
Czasopismo naukowe
Tytuł :
ATP-Gated P2X Receptor Channels: Molecular Insights into Functional Roles.
Autorzy :
Schmid R; Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, United Kingdom; email: .; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester LE1 7RH, United Kingdom.
Evans RJ; Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, United Kingdom; email: .
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Źródło :
Annual review of physiology [Annu Rev Physiol] 2019 Feb 10; Vol. 81, pp. 43-62. Date of Electronic Publication: 2018 Oct 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Adenosine Triphosphate/*metabolism
Ion Channels/*metabolism
Receptors, Purinergic P2X/*metabolism
Animals ; Humans
Czasopismo naukowe
Tytuł :
Organization of ATP-gated P2X1 receptor intracellular termini in apo and desensitized states.
Autorzy :
Fryatt AG; Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.
Dayl S; Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.; Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq.
Stavrou A; Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.
Schmid R; Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, UK.
Evans RJ; Department of Molecular and Cell Biology, University of Leicester, Leicester, UK .
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Źródło :
The Journal of general physiology [J Gen Physiol] 2019 Feb 04; Vol. 151 (2), pp. 146-155. Date of Electronic Publication: 2019 Jan 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, Purinergic P2X1/*chemistry
Amino Acid Substitution ; Cross-Linking Reagents/pharmacology ; Cysteine/chemistry ; Cysteine/genetics ; HEK293 Cells ; Humans ; Molecular Dynamics Simulation ; Protein Conformation/drug effects ; Protein Multimerization ; Purinergic P2X Receptor Agonists/pharmacology ; Receptors, Purinergic P2X1/genetics ; Receptors, Purinergic P2X1/metabolism
Czasopismo naukowe
Tytuł :
Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region.
Autorzy :
Huo H; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.
Fryatt AG; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.
Farmer LK; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.
Schmid R; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, United Kingdom.
Evans RJ; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2018 Aug 17; Vol. 293 (33), pp. 12820-12831. Date of Electronic Publication: 2018 Jul 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Molecular*
Purinergic P2X Receptor Antagonists/*chemistry
Pyridoxal Phosphate/*analogs & derivatives
Receptors, Purinergic P2X1/*chemistry
Animals ; Binding Sites ; Humans ; Pyridoxal Phosphate/chemistry ; Rats ; Receptors, Purinergic P2X1/genetics ; Receptors, Purinergic P2X4/chemistry ; Receptors, Purinergic P2X4/genetics ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Mapping the Allosteric Action of Antagonists A740003 and A438079 Reveals a Role for the Left Flipper in Ligand Sensitivity at P2X7 Receptors.
Autorzy :
Allsopp RC; Department of Molecular and Cell Biology (R.C.A., S.D., A.B.D., R.S., R.J.E.) and Leicester Institute of Structural and Chemical Biology (R.S.), University of Leicester, Leicester, United Kingdom; and Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq (S.D.).
Dayl S; Department of Molecular and Cell Biology (R.C.A., S.D., A.B.D., R.S., R.J.E.) and Leicester Institute of Structural and Chemical Biology (R.S.), University of Leicester, Leicester, United Kingdom; and Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq (S.D.).
Bin Dayel A; Department of Molecular and Cell Biology (R.C.A., S.D., A.B.D., R.S., R.J.E.) and Leicester Institute of Structural and Chemical Biology (R.S.), University of Leicester, Leicester, United Kingdom; and Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq (S.D.).
Schmid R; Department of Molecular and Cell Biology (R.C.A., S.D., A.B.D., R.S., R.J.E.) and Leicester Institute of Structural and Chemical Biology (R.S.), University of Leicester, Leicester, United Kingdom; and Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq (S.D.).
Evans RJ; Department of Molecular and Cell Biology (R.C.A., S.D., A.B.D., R.S., R.J.E.) and Leicester Institute of Structural and Chemical Biology (R.S.), University of Leicester, Leicester, United Kingdom; and Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq (S.D.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2018 May; Vol. 93 (5), pp. 553-562. Date of Electronic Publication: 2018 Mar 13.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetamides/*pharmacology
Purinergic P2X Receptor Antagonists/*pharmacology
Pyridines/*pharmacology
Quinolines/*pharmacology
Receptors, Purinergic P2X7/*drug effects
Tetrazoles/*pharmacology
Allosteric Regulation ; Allosteric Site ; Amino Acid Sequence ; Binding Sites ; Humans ; Ligands ; Molecular Docking Simulation ; Point Mutation ; Receptors, Purinergic P2X7/chemistry ; Receptors, Purinergic P2X7/genetics ; Sequence Homology, Amino Acid
Czasopismo naukowe
Tytuł :
Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120.
Autorzy :
Allsopp RC; Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.
Dayl S; Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.; Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq.
Schmid R; Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, UK.
Evans RJ; Department of Molecular and Cell Biology, University of Leicester, Leicester, UK. .
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Źródło :
Scientific reports [Sci Rep] 2017 Apr 07; Vol. 7 (1), pp. 725. Date of Electronic Publication: 2017 Apr 07.
Typ publikacji :
Journal Article
MeSH Terms :
Allosteric Site*
Binding Sites*
Ion Channel Gating*
Adamantane/*analogs & derivatives
Adenosine Triphosphate/*metabolism
Aminoquinolines/*chemistry
Purinergic P2X Receptor Antagonists/*chemistry
Receptors, Purinergic P2X7/*chemistry
Receptors, Purinergic P2X7/*metabolism
Adamantane/chemistry ; Adamantane/pharmacology ; Alleles ; Allosteric Regulation ; Amino Acid Sequence ; Amino Acid Substitution ; Aminoquinolines/pharmacology ; Humans ; Lignans ; Models, Molecular ; Molecular Conformation ; Mutation ; Protein Binding ; Protein Interaction Domains and Motifs ; Purinergic P2X Receptor Antagonists/pharmacology ; Receptors, Purinergic P2X7/genetics ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
P2X 1 , P2X 4 , and P2X 7 Receptor Knock Out Mice Expose Differential Outcome of Sepsis Induced by α-Haemolysin Producing Escherichia coli .
Autorzy :
Greve AS; Department of Biomedicine, Aarhus UniversityAarhus, Denmark.
Skals M; Department of Biomedicine, Aarhus UniversityAarhus, Denmark.; Department of Clinical Microbiology, Aarhus University HospitalAarhus, Denmark.
Fagerberg SK; Department of Biomedicine, Aarhus UniversityAarhus, Denmark.
Tonnus W; Division of Nephrology, Medical Clinic III, University Hospital Carl Gustav Carus DresdenDresden, Germany.
Ellermann-Eriksen S; Department of Clinical Microbiology, Aarhus University HospitalAarhus, Denmark.
Evans RJ; Department of Molecular and Cell Biology, University of LeicesterLeicester, UK.
Linkermann A; Division of Nephrology, Medical Clinic III, University Hospital Carl Gustav Carus DresdenDresden, Germany.
Praetorius HA; Department of Biomedicine, Aarhus UniversityAarhus, Denmark.
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Źródło :
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2017 Apr 06; Vol. 7, pp. 113. Date of Electronic Publication: 2017 Apr 06 (Print Publication: 2017).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Susceptibility*
Escherichia coli Infections/*pathology
Receptors, Purinergic P2X1/*deficiency
Receptors, Purinergic P2X4/*deficiency
Receptors, Purinergic P2X7/*deficiency
Sepsis/*pathology
Animals ; Disease Models, Animal ; Escherichia coli Infections/genetics ; Mice ; Mice, Knockout ; Survival Analysis ; Treatment Outcome
Czasopismo naukowe

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