Preclinical metabolism and disposition of an orally bioavailable macrocyclic FXIa inhibitor.
Autorzy:
Chacko SA; Department of Nonclinical Research and Development, Bristol Myers Squibb Pharmaceutical Research and Development, Princeton, NJ, USA. Yang W; Discovery Chemistry, Bristol Myers Squibb Pharmaceutical Research and Development, Princeton, NJ, USA. Wang Y; Discovery Chemistry, Bristol Myers Squibb Pharmaceutical Research and Development, Princeton, NJ, USA. Tian Y; Discovery Chemistry, Bristol Myers Squibb Pharmaceutical Research and Development, Princeton, NJ, USA. Hong Y; Discovery Chemistry, Bristol Myers Squibb Pharmaceutical Research and Development, Princeton, NJ, USA. Wallace M; Discovery Chemistry, Bristol Myers Squibb Pharmaceutical Research and Development, Princeton, NJ, USA. Wang B; Department of Nonclinical Research and Development, Bristol Myers Squibb Pharmaceutical Research and Development, Princeton, NJ, USA. EwingWR; Discovery Chemistry, Bristol Myers Squibb Pharmaceutical Research and Development, Princeton, NJ, USA. Luettgen JM; Discovery Biology, Bristol Myers Squibb Pharmaceutical Research and Development, Princeton, NJ, USA. Shu YZ; Department of Nonclinical Research and Development, Bristol Myers Squibb Pharmaceutical Research and Development, Princeton, NJ, USA. Christopher LJ; Department of Nonclinical Research and Development, Bristol Myers Squibb Pharmaceutical Research and Development, Princeton, NJ, USA.
A tautomeric ligand enables directed C‒H hydroxylation with molecular oxygen.
Autorzy:
Li Z; The Scripps Research Institute, La Jolla, CA 92037, USA. Wang Z; The Scripps Research Institute, La Jolla, CA 92037, USA. Chekshin N; The Scripps Research Institute, La Jolla, CA 92037, USA. Qian S; The Scripps Research Institute, La Jolla, CA 92037, USA. Qiao JX; Discovery Chemistry, Bristol-Myers Squibb, Princeton, NJ 08543, USA. Cheng PT; Discovery Chemistry, Bristol-Myers Squibb, Princeton, NJ 08543, USA. Yeung KS; Bristol-Myers Squibb Research and Development, Cambridge, MA 02142, USA. EwingWR; Discovery Chemistry, Bristol-Myers Squibb, Princeton, NJ 08543, USA. Yu JQ; The Scripps Research Institute, La Jolla, CA 92037, USA.
Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies
