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Wyszukujesz frazę ""Excitatory Amino Acid Antagonists"" wg kryterium: Temat


Tytuł :
Efficacy of ketamine for major depressive episodes at 2, 4, and 6-weeks post-treatment: A meta-analysis.
Autorzy :
Conley AA; Department of Psychology, Shippensburg University of Pennsylvania, Shippensburg, PA, 17257, USA. .
Norwood AEQ; Department of Psychology, Shippensburg University of Pennsylvania, Shippensburg, PA, 17257, USA.
Hatvany TC; Department of Psychology, Shippensburg University of Pennsylvania, Shippensburg, PA, 17257, USA.
Griffith JD; Department of Psychology, Shippensburg University of Pennsylvania, Shippensburg, PA, 17257, USA.
Barber KE; Department of Psychology, Shippensburg University of Pennsylvania, Shippensburg, PA, 17257, USA.
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2021 Jul; Vol. 238 (7), pp. 1737-1752. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji :
Journal Article; Meta-Analysis; Review
MeSH Terms :
Clinical Trials as Topic/*methods
Depressive Disorder, Major/*drug therapy
Depressive Disorder, Major/*psychology
Excitatory Amino Acid Antagonists/*therapeutic use
Ketamine/*therapeutic use
Affect/drug effects ; Affect/physiology ; Depressive Disorder, Major/diagnosis ; Excitatory Amino Acid Antagonists/pharmacology ; Humans ; Ketamine/pharmacology ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Recent Developments in New Therapeutic Agents against Alzheimer and Parkinson Diseases: In-Silico Approaches.
Autorzy :
Cruz-Vicente P; CICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6201-001 Covilhã, Portugal.; UCIBIO-Applied Molecular Biosciences Unit, Department of Chemistry, Faculty of Sciences and Technology, NOVA University Lisbon, 2829-516 Caparica, Portugal.
Passarinha LA; CICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6201-001 Covilhã, Portugal.; UCIBIO-Applied Molecular Biosciences Unit, Department of Chemistry, Faculty of Sciences and Technology, NOVA University Lisbon, 2829-516 Caparica, Portugal.; Laboratory of Pharmaco-Toxicology-UBIMedical, University of Beira Interior, 6200-001 Covilhã, Portugal.
Silvestre S; CICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6201-001 Covilhã, Portugal.; Laboratory of Pharmaco-Toxicology-UBIMedical, University of Beira Interior, 6200-001 Covilhã, Portugal.; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
Gallardo E; CICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6201-001 Covilhã, Portugal.; Laboratory of Pharmaco-Toxicology-UBIMedical, University of Beira Interior, 6200-001 Covilhã, Portugal.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 11; Vol. 26 (8). Date of Electronic Publication: 2021 Apr 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease/*drug therapy
Antiparkinson Agents/*therapeutic use
Cholinesterase Inhibitors/*therapeutic use
Dopamine Agents/*therapeutic use
Excitatory Amino Acid Antagonists/*therapeutic use
Neuroprotective Agents/*therapeutic use
Parkinson Disease/*drug therapy
Acetylcholinesterase/genetics ; Acetylcholinesterase/metabolism ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/metabolism ; Antiparkinson Agents/chemical synthesis ; Aspartic Acid Endopeptidases/antagonists & inhibitors ; Aspartic Acid Endopeptidases/genetics ; Aspartic Acid Endopeptidases/metabolism ; Catechol O-Methyltransferase/genetics ; Catechol O-Methyltransferase/metabolism ; Cholinesterase Inhibitors/chemical synthesis ; Clinical Trials as Topic ; Computer Simulation ; Dopamine Agents/chemical synthesis ; Drug Design ; Excitatory Amino Acid Antagonists/chemical synthesis ; GPI-Linked Proteins/antagonists & inhibitors ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; Gene Expression Regulation ; Humans ; Neuroprotective Agents/chemical synthesis ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism ; Sirtuins/antagonists & inhibitors ; Sirtuins/genetics ; Sirtuins/metabolism
Czasopismo naukowe
Tytuł :
Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2.
Autorzy :
Krintel C; Research Cluster on Molecular Neuroprotection, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Dorosz J; Research Cluster on Molecular Neuroprotection, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Larsen AH; Structural Biophysics, X-ray and Neutron Science, The Niels Bohr Institute, University of Copenhagen, Denmark.
Thorsen TS; Research Cluster on Molecular Neuroprotection, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Venskutonytė R; Research Cluster on Molecular Neuroprotection, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Department of Experimental Medical Science, Lund University, Lund, 221 00, Sweden.
Mirza O; Research Cluster on Molecular Neuroprotection, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Gajhede M; Research Cluster on Molecular Neuroprotection, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Boesen T; Department of Molecular Biology and Genetics, Aarhus University, Denmark.
Kastrup JS; Research Cluster on Molecular Neuroprotection, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
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Źródło :
The FEBS journal [FEBS J] 2021 Feb; Vol. 288 (3), pp. 995-1007. Date of Electronic Publication: 2020 Jul 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzodiazepines/*metabolism
Excitatory Amino Acid Antagonists/*metabolism
Organophosphonates/*metabolism
Quinoxalines/*metabolism
Receptors, AMPA/*metabolism
Recombinant Proteins/*metabolism
Allosteric Regulation ; Animals ; Benzodiazepines/chemistry ; Benzodiazepines/pharmacology ; Crystallography, X-Ray ; Excitatory Amino Acid Antagonists/chemistry ; Excitatory Amino Acid Antagonists/pharmacology ; HEK293 Cells ; Humans ; Models, Molecular ; Molecular Structure ; Organophosphonates/chemistry ; Organophosphonates/pharmacology ; Protein Binding ; Protein Domains ; Quinoxalines/chemistry ; Quinoxalines/pharmacology ; Rats ; Receptors, AMPA/antagonists & inhibitors ; Receptors, AMPA/genetics ; Recombinant Proteins/chemistry ; Sf9 Cells ; Spodoptera
Czasopismo naukowe
Tytuł :
A Conantokin Peptide Con-T[M8Q] Inhibits Morphine Dependence with High Potency and Low Side Effects.
Autorzy :
Liu Z; Beijing Institute of Biotechnology, Beijing 100071, China.
Yu Z; Beijing Institute of Biotechnology, Beijing 100071, China.
Yu S; Beijing Institute of Biotechnology, Beijing 100071, China.
Zhu C; Beijing Institute of Biotechnology, Beijing 100071, China.
Dong M; Beijing Institute of Biotechnology, Beijing 100071, China.
Mao W; Beijing Institute of Biotechnology, Beijing 100071, China.
Hu J; Beijing Institute of Biotechnology, Beijing 100071, China.
Prorok M; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Su R; Beijing Institute of Toxicology and Pharmacology, Beijing 100850, China.
Dai Q; Beijing Institute of Biotechnology, Beijing 100071, China.
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Źródło :
Marine drugs [Mar Drugs] 2021 Jan 19; Vol. 19 (1). Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Conotoxins/*pharmacology
Excitatory Amino Acid Antagonists/*pharmacology
Morphine Dependence/*drug therapy
Receptors, N-Methyl-D-Aspartate/*drug effects
Animals ; Conotoxins/administration & dosage ; Conotoxins/toxicity ; Disease Models, Animal ; Excitatory Amino Acid Antagonists/administration & dosage ; Excitatory Amino Acid Antagonists/toxicity ; Hippocampus/drug effects ; Hippocampus/metabolism ; Locomotion/drug effects ; Male ; Mice ; Morphine Dependence/physiopathology ; Naloxone/pharmacology ; Piperidines/pharmacology ; Spatial Memory/drug effects
Czasopismo naukowe
Tytuł :
Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104.
Autorzy :
Lajkó N; Department of Cell Biology and Molecular Medicine, University of Szeged, 6720 Szeged, Hungary.
Kata D; Department of Laboratory Medicine, University of Szeged, 6720 Szeged, Hungary.
Szabó M; Department of Cell Biology and Molecular Medicine, University of Szeged, 6720 Szeged, Hungary.
Mátyás A; Department of Anatomy, University of Szeged, 6720 Szeged, Hungary.
Dulka K; Department of Cell Biology and Molecular Medicine, University of Szeged, 6720 Szeged, Hungary.
Földesi I; Department of Laboratory Medicine, University of Szeged, 6720 Szeged, Hungary.
Fülöp F; Institute of Pharmaceutical Chemistry and Research Group for Stereochemistry, Hungarian Academy of Sciences, University of Szeged, 6720 Szeged, Hungary.
Gulya K; Department of Cell Biology and Molecular Medicine, University of Szeged, 6720 Szeged, Hungary.
Vécsei L; Department of Neurology, University of Szeged, 6720 Szeged, Hungary.; Department of Neurology, Interdisciplinary Excellence Centre, University of Szeged, 6720 Szeged, Hungary.
Mihály A; Department of Anatomy, University of Szeged, 6720 Szeged, Hungary.; Department of Anatomy, Faculty of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 07; Vol. 21 (23). Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article
MeSH Terms :
Epilepsy/*metabolism
Excitatory Amino Acid Antagonists/*pharmacology
Kynurenic Acid/*analogs & derivatives
Microglia/*metabolism
Phagocytosis/*drug effects
Animals ; Calcium-Binding Proteins/metabolism ; Cells, Cultured ; Epilepsy/etiology ; Excitatory Amino Acid Antagonists/chemistry ; Lipopolysaccharides/toxicity ; Male ; Mice ; Microfilament Proteins/metabolism ; Microglia/drug effects ; Pilocarpine/toxicity
Czasopismo naukowe
Tytuł :
Sex-related differences in intravenous ketamine effects on dissociative stereotypy and antinociception in male and female rats.
Autorzy :
Radford KD; Daniel K. Inouye Graduate School of Nursing, Uniformed Services University, Bethesda, MD 20814, USA.
Berman RY; Department of Psychiatry, Uniformed Services University, Bethesda, MD 20814, USA.
Zhang M; Department of Psychiatry, Uniformed Services University, Bethesda, MD 20814, USA; Center for the Study of Traumatic Stress, Uniformed Services University, Bethesda, MD 20814, USA.
Wu TJ; Department of Obstetrics and Gynecology, Uniformed Services University, Bethesda, MD 20814, USA; Program in Neuroscience, Uniformed Services University, Bethesda, MD 20814, USA.
Choi KH; Daniel K. Inouye Graduate School of Nursing, Uniformed Services University, Bethesda, MD 20814, USA; Department of Psychiatry, Uniformed Services University, Bethesda, MD 20814, USA; Center for the Study of Traumatic Stress, Uniformed Services University, Bethesda, MD 20814, USA; Program in Neuroscience, Uniformed Services University, Bethesda, MD 20814, USA. Electronic address: .
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Źródło :
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2020 Dec; Vol. 199, pp. 173042. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Analgesia*
Sex Factors*
Excitatory Amino Acid Antagonists/*administration & dosage
Ketamine/*administration & dosage
Stereotyped Behavior/*drug effects
Animals ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Antagonists/pharmacology ; Female ; Injections, Intravenous ; Ketamine/pharmacology ; Male ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Sarcophine and (7S, 8R)-dihydroxydeepoxysarcophine from the Red Sea soft coral Sarcophyton glaucum as in vitro and in vivo modulators of glycine receptors.
Autorzy :
Saleh HA; Department of Pharmaceutical Chemistry, German University in Cairo, New Cairo, Egypt.
Raafat KM; Department of Biochemistry, German University in Cairo, New Cairo, Egypt.
Temraz TA; Department of Marine Sciences, Suez Canal University, Ismailia, Egypt.
Noureldin N; Department of Pharmaceutical Chemistry, German University in Cairo, New Cairo, Egypt. Electronic address: .
Breitinger HG; Department of Biochemistry, German University in Cairo, New Cairo, Egypt. Electronic address: .
Breitinger U; Department of Biochemistry, German University in Cairo, New Cairo, Egypt.
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Źródło :
Neurotoxicology [Neurotoxicology] 2020 Sep; Vol. 80, pp. 105-111. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
4-Butyrolactone/*analogs & derivatives
Anthozoa/*metabolism
Brain/*drug effects
Excitatory Amino Acid Antagonists/*pharmacology
Receptors, Glycine/*antagonists & inhibitors
Seizures/*prevention & control
4-Butyrolactone/chemical synthesis ; 4-Butyrolactone/isolation & purification ; 4-Butyrolactone/pharmacology ; 4-Butyrolactone/toxicity ; Animals ; Binding Sites ; Binding, Competitive ; Brain/metabolism ; Brain/physiopathology ; Disease Models, Animal ; Excitatory Amino Acid Antagonists/chemical synthesis ; Excitatory Amino Acid Antagonists/isolation & purification ; Excitatory Amino Acid Antagonists/toxicity ; HEK293 Cells ; Humans ; Male ; Mice ; Protein Binding ; Receptors, Glycine/genetics ; Receptors, Glycine/metabolism ; Seizures/chemically induced ; Seizures/metabolism ; Seizures/physiopathology ; Strychnine
Czasopismo naukowe
Tytuł :
Happiness During Low-Dose Ketamine Infusion Predicts Treatment Response: Reexploring the Adjunctive Ketamine Study of Taiwanese Patients With Treatment-Resistant Depression.
Autorzy :
Chen MH; Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
Lin WC; Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
Wu HJ; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Bai YM; Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Li CT; Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
Tsai SJ; Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
Hong CJ; Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
Tu PC; Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Cheng CM; Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
Su TP; Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Sec 2, Shih-Pai Rd, Beitou District, Taipei, 112, Taiwan. .; Division of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.; Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan.
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Źródło :
The Journal of clinical psychiatry [J Clin Psychiatry] 2020 Nov 10; Vol. 81 (6). Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Happiness*
Outcome Assessment, Health Care*
Depressive Disorder, Treatment-Resistant/*drug therapy
Excitatory Amino Acid Antagonists/*pharmacology
Ketamine/*pharmacology
Adult ; Depressive Disorder, Treatment-Resistant/physiopathology ; Excitatory Amino Acid Antagonists/administration & dosage ; Female ; Follow-Up Studies ; Humans ; Infusions, Intravenous ; Ketamine/administration & dosage ; Male ; Middle Aged ; Severity of Illness Index ; Taiwan
Czasopismo naukowe
Tytuł :
A Proof-of-Concept Study of Subanesthetic Intravenous Ketamine Combined With Prolonged Exposure Therapy Among Veterans With Posttraumatic Stress Disorder.
Autorzy :
Shiroma PR; One Veterans Dr 116-A, Minneapolis, MN 55417. .; Mental Health Service Line, Minneapolis VA Health Care System, Minneapolis, Minnesota, USA.; Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA.
Thuras P; Mental Health Service Line, Minneapolis VA Health Care System, Minneapolis, Minnesota, USA.; Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA.
Wels J; Mental Health Service Line, Minneapolis VA Health Care System, Minneapolis, Minnesota, USA.; University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Erbes C; Mental Health Service Line, Minneapolis VA Health Care System, Minneapolis, Minnesota, USA.; Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA.
Kehle-Forbes S; Center for Chronic Disease Outcomes Research, Minneapolis, Minnesota, USA.; Women's Health Sciences Division of the National Center for PTSD, Boston, Massachusetts, USA.; Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Polusny M; Mental Health Service Line, Minneapolis VA Health Care System, Minneapolis, Minnesota, USA.; Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA.
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Źródło :
The Journal of clinical psychiatry [J Clin Psychiatry] 2020 Nov 10; Vol. 81 (6). Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Implosive Therapy*/methods
Veterans*
Excitatory Amino Acid Antagonists/*pharmacology
Ketamine/*pharmacology
Stress Disorders, Post-Traumatic/*therapy
Administration, Intravenous ; Adolescent ; Adult ; Aged ; Combined Modality Therapy ; Excitatory Amino Acid Antagonists/administration & dosage ; Feasibility Studies ; Humans ; Ketamine/administration & dosage ; Male ; Middle Aged ; Outcome Assessment, Health Care ; Pilot Projects ; Stress Disorders, Post-Traumatic/drug therapy ; Young Adult
Czasopismo naukowe
Tytuł :
Nasal respiration is necessary for ketamine-dependent high frequency network oscillations and behavioral hyperactivity in rats.
Autorzy :
Wróbel J; Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093, Warsaw, Poland.
Średniawa W; Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093, Warsaw, Poland.; Faculty of Biology, University of Warsaw, 02-096, Warsaw, Poland.
Jurkiewicz G; Faculty of Physics, University of Warsaw, 02-096, Warsaw, Poland.
Żygierewicz J; Faculty of Physics, University of Warsaw, 02-096, Warsaw, Poland.
Wójcik DK; Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093, Warsaw, Poland.; Faculty of Management and Social Communication, Jagiellonian University, 30-348, Cracow, Poland.
Whittington MA; University of York, Heslington, York, YO10 5DD, UK.
Hunt MJ; Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093, Warsaw, Poland. .
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 04; Vol. 10 (1), pp. 18981. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Excitatory Amino Acid Antagonists/*administration & dosage
Ketamine/*administration & dosage
Motor Activity/*drug effects
Nose/*physiology
Respiration/*drug effects
Animals ; Behavior, Animal/drug effects ; Excitatory Amino Acid Antagonists/pharmacology ; Haloperidol/adverse effects ; Ketamine/pharmacology ; Male ; Nose/drug effects ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/physiology ; Rats ; Rats, Wistar ; Theta Rhythm/drug effects ; Ventral Striatum/drug effects ; Ventral Striatum/physiology
Czasopismo naukowe
Tytuł :
Randomized Controlled Trial of Riluzole Augmentation for Posttraumatic Stress Disorder: Efficacy of a Glutamatergic Modulator for Antidepressant-Resistant Symptoms.
Autorzy :
Spangler PT; Patricia Spangler, PhD, Department of Psychiatry, Uniformed Services University, 4301 Jones Bridge Rd, Bethesda, MD 20816. .; Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University, Bethesda, Maryland, USA.; Henry M. Jackson Foundation, Bethesda, Maryland, USA.
West JC; Department of Psychiatry, Uniformed Services University, Bethesda, Maryland, USA.
Dempsey CL; Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University, Bethesda, Maryland, USA.; Henry M. Jackson Foundation, Bethesda, Maryland, USA.
Possemato K; Veterans Administration Center for Integrated Healthcare, Syracuse, New York, USA.
Bartolanzo D; Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University, Bethesda, Maryland, USA.; Henry M. Jackson Foundation, Bethesda, Maryland, USA.
Aliaga P; Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University, Bethesda, Maryland, USA.; Henry M. Jackson Foundation, Bethesda, Maryland, USA.
Zarate C; Experimental Therapeutics & Pathophysiology Branch, National Institute of Mental Health, Bethesda, Maryland, USA.
Vythilingam M; Senior Mental Health Advisor, Office of the Assistant Secretary for Health, Washington, DC, USA.
Benedek DM; Department of Psychiatry, Uniformed Services University, Bethesda, Maryland, USA.
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Źródło :
The Journal of clinical psychiatry [J Clin Psychiatry] 2020 Oct 27; Vol. 81 (6). Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Excitatory Amino Acid Antagonists/*pharmacology
Riluzole/*pharmacology
Serotonin Uptake Inhibitors/*pharmacology
Serotonin and Noradrenaline Reuptake Inhibitors/*pharmacology
Stress Disorders, Post-Traumatic/*drug therapy
Stress Disorders, Post-Traumatic/*physiopathology
Adult ; Anxiety/drug therapy ; Depression/drug therapy ; Double-Blind Method ; Drug Synergism ; Drug Therapy, Combination ; Excitatory Amino Acid Antagonists/administration & dosage ; Female ; Humans ; Male ; Middle Aged ; Military Personnel ; Riluzole/administration & dosage ; Veterans
Czasopismo naukowe
Tytuł :
Repeated ketamine administration induces recognition memory impairment together with morphological changes in neurons from ventromedial prefrontal cortex, dorsal striatum, and hippocampus.
Autorzy :
Suárez-Santiago JE; Escuela Superior de Medicina, Instituto Politécnico Nacional.
Orozco-Suárez S; Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México.
Vega-García A; Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México.; Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México México.
Bautista-Orozco LÁ; Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México.
Picazo O; Escuela Superior de Medicina, Instituto Politécnico Nacional.
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Źródło :
Behavioural pharmacology [Behav Pharmacol] 2020 Oct; Vol. 31 (7), pp. 633-640.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Excitatory Amino Acid Antagonists/*toxicity
Ketamine/*toxicity
Memory Disorders/*chemically induced
Recognition, Psychology/*drug effects
Animals ; Corpus Striatum/drug effects ; Dendritic Spines/drug effects ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Antagonists/administration & dosage ; Hippocampus/drug effects ; Ketamine/administration & dosage ; Male ; Mice ; Mice, Inbred ICR ; Neuronal Plasticity/drug effects ; Neurons/drug effects ; Prefrontal Cortex/drug effects ; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Memantine for Prevention of Brain Irradiation-Induced Cognitive Toxicity: A Tale of an Underappreciated and Underused Intervention.
Autorzy :
Chilukuri S; Department of Radiation Oncology, Apollo Proton Cancer Centre, Chennai, India.
Burela N; Department of Radiation Oncology, Apollo Proton Cancer Centre, Chennai, India.
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Źródło :
JCO global oncology [JCO Glob Oncol] 2020 Sep; Vol. 6, pp. 1384-1388.
Typ publikacji :
Journal Article
MeSH Terms :
Excitatory Amino Acid Antagonists*
Memantine*/therapeutic use
Brain ; Cognition ; Cranial Irradiation
Czasopismo naukowe
Tytuł :
l-α-aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory.
Autorzy :
Pereira MF; Center for Neuroscience and Cell Biology, CNC, Coimbra, Portugal.
Amaral IM; Center for Neuroscience and Cell Biology, CNC, Coimbra, Portugal.
Lopes C; Center for Neuroscience and Cell Biology, CNC, Coimbra, Portugal.
Leitão C; Center for Neuroscience and Cell Biology, CNC, Coimbra, Portugal.
Madeira D; Center for Neuroscience and Cell Biology, CNC, Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, FMUC, Coimbra, Portugal.
Lopes JP; Center for Neuroscience and Cell Biology, CNC, Coimbra, Portugal.
Gonçalves FQ; Center for Neuroscience and Cell Biology, CNC, Coimbra, Portugal.
Canas PM; Center for Neuroscience and Cell Biology, CNC, Coimbra, Portugal.
Cunha RA; Center for Neuroscience and Cell Biology, CNC, Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, FMUC, Coimbra, Portugal.
Agostinho P; Center for Neuroscience and Cell Biology, CNC, Coimbra, Portugal.; Faculty of Medicine, University of Coimbra, FMUC, Coimbra, Portugal.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Aug; Vol. 35 (8), pp. e21726.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
2-Aminoadipic Acid/*toxicity
Astrocytes/*drug effects
Hippocampus/*drug effects
Hippocampus/*physiopathology
2-Aminoadipic Acid/administration & dosage ; 2-Aminoadipic Acid/antagonists & inhibitors ; Adenosine Triphosphate/metabolism ; Animals ; Astrocytes/pathology ; Astrocytes/physiology ; Cells, Cultured ; Excitatory Amino Acid Antagonists/administration & dosage ; Excitatory Amino Acid Antagonists/toxicity ; Glial Fibrillary Acidic Protein/metabolism ; Glutamic Acid/metabolism ; Hippocampus/pathology ; In Vitro Techniques ; Injections, Intraventricular ; Long-Term Potentiation/drug effects ; Long-Term Potentiation/physiology ; Male ; Memory/drug effects ; Memory/physiology ; Mice ; Mice, Inbred C57BL ; Neuronal Plasticity/drug effects ; Neuronal Plasticity/physiology ; Serine/administration & dosage ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology
Czasopismo naukowe
Tytuł :
Dextromethorphan Attenuates Sensorineural Hearing Loss in an Animal Model and Population-Based Cohort Study.
Autorzy :
Chen HC; Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Wang CH; Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114, Taiwan.
Chien WC; School of Public Health, National Defense Medical Center, Taipei 114, Taiwan.; Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Chung CH; School of Public Health, National Defense Medical Center, Taipei 114, Taiwan.; Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Shih CP; Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Lin YC; Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114, Taiwan.
Li IH; Department of Pharmacy Practice, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.; School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan.
Lin YY; Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114, Taiwan.
Kuo CY; Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
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Źródło :
International journal of environmental research and public health [Int J Environ Res Public Health] 2020 Aug 31; Vol. 17 (17). Date of Electronic Publication: 2020 Aug 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dextromethorphan*/pharmacology
Dextromethorphan*/therapeutic use
Excitatory Amino Acid Antagonists*/pharmacology
Excitatory Amino Acid Antagonists*/therapeutic use
Hearing Loss, Noise-Induced*
Hearing Loss, Sensorineural*/drug therapy
Hearing Loss, Sensorineural*/prevention & control
Adult ; Animals ; Cohort Studies ; Female ; Humans ; Male ; Mice ; Mice, Inbred CBA ; Retrospective Studies ; Taiwan
Czasopismo naukowe
Tytuł :
Is Memantine Effective as an NMDA-Receptor Antagonist in Adjunctive Therapy for Schizophrenia?
Autorzy :
Kikuchi T; New Drug Research Division, Pharmaceutical Business Division, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima 771-0192, Japan.
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Źródło :
Biomolecules [Biomolecules] 2020 Jul 31; Vol. 10 (8). Date of Electronic Publication: 2020 Jul 31.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antipsychotic Agents/*therapeutic use
Excitatory Amino Acid Antagonists/*therapeutic use
Memantine/*therapeutic use
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Schizophrenia/*drug therapy
Animals ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Drug Combinations ; Excitatory Amino Acid Antagonists/administration & dosage ; Excitatory Amino Acid Antagonists/adverse effects ; Humans ; Memantine/administration & dosage ; Memantine/adverse effects
Czasopismo naukowe
Tytuł :
Test-retest reliability of tone- and 40 Hz train-evoked gamma oscillations in female rats and their sensitivity to low-dose NMDA channel blockade.
Autorzy :
Raza MU; Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, VA Building 7, Room 324, Maple Ave, Johnson City, TN, 37604, USA.
Sivarao DV; Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, VA Building 7, Room 324, Maple Ave, Johnson City, TN, 37604, USA. .
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2021 Aug; Vol. 238 (8), pp. 2325-2334. Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
Excitatory Amino Acid Antagonists/*pharmacology
Gamma Rhythm/*drug effects
Gamma Rhythm/*physiology
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate/*physiology
Acoustic Stimulation/methods ; Acoustic Stimulation/standards ; Animals ; Dizocilpine Maleate/pharmacology ; Dose-Response Relationship, Drug ; Evoked Potentials, Auditory/drug effects ; Evoked Potentials, Auditory/physiology ; Excitatory Amino Acid Agonists/pharmacology ; Female ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/agonists ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
UVB Radiation and Selected Tryptophan-Derived AhR Ligands-Potential Biological Interactions in Melanoma Cells.
Autorzy :
Walczak K; Department of Pharmacology, Medical University of Lublin, Chodźki 4a, 20093 Lublin, Poland.
Kazimierczak P; Department of Biochemistry and Biotechnology, Medical University of Lublin, Chodźki 1, 20093 Lublin, Poland.
Szalast K; Department of Pharmacology, Medical University of Lublin, Chodźki 4a, 20093 Lublin, Poland.
Plech T; Department of Pharmacology, Medical University of Lublin, Chodźki 4a, 20093 Lublin, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 13; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 13.
Typ publikacji :
Journal Article
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Kynurenic Acid/*adverse effects
Kynurenine/*adverse effects
Melanoma/*pathology
Receptors, Aryl Hydrocarbon/*metabolism
Ultraviolet Rays/*adverse effects
Excitatory Amino Acid Antagonists/adverse effects ; Humans ; Ligands ; Melanoma/etiology ; Melanoma/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Brivaracetam prevents astroglial l-glutamate release associated with hemichannel through modulation of synaptic vesicle protein.
Autorzy :
Okada M; Department of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu, Mie 514-8507, Japan. Electronic address: .
Fukuyama K; Department of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu, Mie 514-8507, Japan. Electronic address: .
Shiroyama T; Department of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu, Mie 514-8507, Japan. Electronic address: .
Ueda Y; Department of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu, Mie 514-8507, Japan. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jun; Vol. 138, pp. 111462. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article
MeSH Terms :
Astrocytes/*metabolism
Glutamic Acid/*metabolism
Membrane Glycoproteins/*antagonists & inhibitors
Membrane Glycoproteins/*metabolism
Nerve Tissue Proteins/*metabolism
Pyrrolidinones/*pharmacology
Animals ; Animals, Newborn ; Anticonvulsants/pharmacology ; Astrocytes/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Antagonists/pharmacology ; Female ; Male ; Nerve Tissue Proteins/antagonists & inhibitors ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA/antagonists & inhibitors ; Receptors, AMPA/metabolism ; Receptors, Glutamate/metabolism ; Synaptic Vesicles/drug effects ; Synaptic Vesicles/metabolism ; Tumor Necrosis Factor-alpha/pharmacology
Czasopismo naukowe
Tytuł :
Synthetic structural modifications of neurosteroid pregnanolone sulfate: Assessment of neuroprotective effects in vivo.
Autorzy :
Chvojkova M; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Czech Republic; National Institute of Mental Health, Topolova 748, 250 67, Klecany, Czech Republic; 2nd Faculty of Medicine, Charles University, V Uvalu 84, 150 06, Prague 5 - Motol, Czech Republic. Electronic address: .
Rambousek L; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Czech Republic.
Chodounska H; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo namesti 2, 166 10, Prague 6, Czech Republic.
Kudova E; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo namesti 2, 166 10, Prague 6, Czech Republic.
Vales K; Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague 4, Czech Republic; National Institute of Mental Health, Topolova 748, 250 67, Klecany, Czech Republic.
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 Aug 15; Vol. 881, pp. 173187. Date of Electronic Publication: 2020 May 21.
Typ publikacji :
Journal Article
MeSH Terms :
Behavior, Animal/*drug effects
Excitatory Amino Acid Antagonists/*pharmacology
Hippocampus/*drug effects
Neuroprotective Agents/*pharmacology
Pregnanolone/*pharmacology
Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
Sulfates/*pharmacology
Animals ; Dose-Response Relationship, Drug ; Excitatory Amino Acid Agonists/toxicity ; Excitatory Amino Acid Antagonists/chemical synthesis ; Hippocampus/metabolism ; Hippocampus/pathology ; Hippocampus/physiopathology ; Locomotion/drug effects ; Male ; Maze Learning/drug effects ; Mice ; Molecular Structure ; Motor Activity/drug effects ; N-Methylaspartate/toxicity ; Neuroprotective Agents/chemical synthesis ; Pregnanolone/analogs & derivatives ; Pregnanolone/chemical synthesis ; Rats, Long-Evans ; Receptors, N-Methyl-D-Aspartate/metabolism ; Structure-Activity Relationship ; Sulfates/chemical synthesis
Czasopismo naukowe

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