Temat: "Extracellular Signal-Regulated MAP Kinases" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: mGluR1/IP3/ERK signaling pathway regulates vestibular compensation in ON UBCs of the cerebellar flocculus.
Autorzy:: Liu D; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Institute of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wang J; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Institute of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tian E; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Institute of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chen J; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Institute of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Kong W; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Institute of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lu Y; Department of Physiology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China.; Institute of Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China.
Zhang S; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Institute of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Pokaż więcej
Źródło:: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Feb; Vol. 30 (2), pp. e14419. Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Extracellular Signal-Regulated MAP Kinases*
Signal Transduction*
Benzoates*
Receptors, Metabotropic Glutamate*
Glycine/*analogs & derivatives
Methoxyhydroxyphenylglycol/*analogs & derivatives
Rats ; Animals

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Skocz do pozycji: 2.

Tytuł:: MAPK-ERK Pathway.
Autorzy:: Park JI; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 02; Vol. 24 (11). Date of Electronic Publication: 2023 Jun 02.
Typ publikacji:: Editorial
MeSH Terms:: Extracellular Signal-Regulated MAP Kinases*/metabolism
Signal Transduction*/physiology
Animals ; MAP Kinase Signaling System/physiology ; Phosphorylation ; Mammals/metabolism

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Skocz do pozycji: 3.

Tytuł:: Insights into the leveraging of GABAergic signaling in cancer therapy.
Autorzy:: Li TJ; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Jiang J; Department of Head and Neck Surgery, Sichuan Cancer Center, School of Medicine, Sichuan Cancer Hospital & Institute, University of Electronic Science and Technology of China, Chengdu, China.
Tang YL; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Liang XH; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Pokaż więcej
Źródło:: Cancer medicine [Cancer Med] 2023 Jul; Vol. 12 (13), pp. 14498-14510. Date of Electronic Publication: 2023 May 18.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:: Signal Transduction*
gamma-Aminobutyric Acid*/metabolism
gamma-Aminobutyric Acid*/pharmacology
Animals ; Humans ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Carcinogenesis/metabolism ; Cell Line, Tumor ; Mammals/metabolism ; Tumor Microenvironment

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Skocz do pozycji: 4.

Tytuł:: The MAPK/ERK channel capacity exceeds 6 bit/hour.
Autorzy:: Nałęcz-Jawecki P; Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland.
Gagliardi PA; Institute of Cell Biology, University of Bern, Bern, Switzerland.
Kochańczyk M; Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland.
Dessauges C; Institute of Cell Biology, University of Bern, Bern, Switzerland.
Pertz O; Institute of Cell Biology, University of Bern, Bern, Switzerland.
Lipniacki T; Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2023 May 22; Vol. 19 (5), pp. e1011155. Date of Electronic Publication: 2023 May 22 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: MAP Kinase Signaling System*/physiology
Signal Transduction*
Cell Line ; Epithelial Cells/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism

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Skocz do pozycji: 5.

Tytuł:: Regulation of Cortico-Thalamic JNK1/2 and ERK1/2 MAPKs and Apoptosis-Related Signaling Pathways in PDYN Gene-Deficient Mice Following Acute and Chronic Mild Stress.
Autorzy:: Yáñez-Gómez F; Laboratorio de Neurofarmacología, IUNICS, Universitat de les Illes Balears, Crta. Valldemossa km 7.5, 07122 Palma de Mallorca, Spain.; Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.
Ramos-Miguel A; Department of Pharmacology, University of the Basque Country (UPV/EHU), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barrio Sarriena S/N, 48940 Leioa, Spain.; BioCruces Bizkaia Health Research Institute, Plaza de Cruces 12, 48903 Barakaldo, Spain.
García-Sevilla JA; Laboratorio de Neurofarmacología, IUNICS, Universitat de les Illes Balears, Crta. Valldemossa km 7.5, 07122 Palma de Mallorca, Spain.
Manzanares J; Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC, Avda. de Ramón y Cajal s/n, San Juan de Alicante, 03550 Alicante, Spain.; Redes de Investigación Cooperativa Orientada a Resultados en Salud (RICORS), Red de Investigación en Atención Primaria de Adicciones (RIAPAd), Instituto de Salud Carlos III, MICINN and FEDER, 28029 Madrid, Spain.; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), 03010 Alicante, Spain.
Femenía T; Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC, Avda. de Ramón y Cajal s/n, San Juan de Alicante, 03550 Alicante, Spain.; Redes de Investigación Cooperativa Orientada a Resultados en Salud (RICORS), Red de Investigación en Atención Primaria de Adicciones (RIAPAd), Instituto de Salud Carlos III, MICINN and FEDER, 28029 Madrid, Spain.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Jan 24; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 24.
Typ publikacji:: Journal Article
MeSH Terms:: Proto-Oncogene Proteins c-akt*/metabolism
Signal Transduction*/physiology
Mice ; Animals ; Apoptosis/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Mitogen-Activated Protein Kinase Kinases/metabolism ; TOR Serine-Threonine Kinases/metabolism ; JNK Mitogen-Activated Protein Kinases/metabolism ; Phosphorylation ; p38 Mitogen-Activated Protein Kinases/metabolism

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Skocz do pozycji: 6.

Tytuł:: Melochia corchorifolia extract inhibits melanogenesis in B16F10 mouse melanoma cells via activation of the ERK signaling.
Autorzy:: Yuan XH; Department of Dermatology, Yanbian University Hospital, Yanji, China.; Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.; Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.; Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, Korea.
Tian YD; Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.; Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.; Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, Korea.; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.
Oh JH; Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.; Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.; Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, Korea.
Bach TT; Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
Chung JH; Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.; Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.; Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, Korea.; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.
Jin ZH; Department of Dermatology, Yanbian University Hospital, Yanji, China.; Pokaż więcej
Źródło:: Journal of cosmetic dermatology [J Cosmet Dermatol] 2020 Sep; Vol. 19 (9), pp. 2421-2427. Date of Electronic Publication: 2020 Jan 03.
Typ publikacji:: Journal Article
MeSH Terms:: Extracellular Signal-Regulated MAP Kinases*/metabolism
Melanoma, Experimental*/drug therapy
Signal Transduction*
Malvaceae/*chemistry
Plant Extracts/*therapeutic use
Animals ; Melanins ; Mice ; Monophenol Monooxygenase/genetics ; Monophenol Monooxygenase/metabolism

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Skocz do pozycji: 7.

Tytuł:: KRAS Affects Adipogenic Differentiation by Regulating Autophagy and MAPK Activation in 3T3-L1 and C2C12 Cells.
Autorzy:: Yu W; Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, China.
Chen CZ; Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, China.
Peng Y; Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, China.
Li Z; Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, China.
Gao Y; Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, China.
Liang S; Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, China.
Yuan B; Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, China.
Kim NH; Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, China.; Department of Animal Science, Chungbuk National University, Cheongju 361-763, Chungbuk, Korea.
Jiang H; Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, China.
Zhang JB; Department of Laboratory Animals, Jilin Provincial Key Laboratory of Animal Model, Jilin University, Changchun 130062, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Dec 20; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 20.
Typ publikacji:: Journal Article
MeSH Terms:: Adipogenesis*
Autophagy*
Cell Proliferation*
Signal Transduction*
Fibroblasts/*metabolism
Myoblasts/*metabolism
Proto-Oncogene Proteins p21(ras)/*physiology
3T3 Cells ; Animals ; CCAAT-Enhancer-Binding Protein-beta/genetics ; Cells, Cultured ; Diacylglycerol O-Acyltransferase/genetics ; Extracellular Signal-Regulated MAP Kinases/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Fibroblasts/physiology ; Gene Expression Regulation ; JNK Mitogen-Activated Protein Kinases/genetics ; JNK Mitogen-Activated Protein Kinases/metabolism ; Lipid Metabolism ; Mice ; Myoblasts/physiology ; PPAR gamma/genetics ; Proliferating Cell Nuclear Antigen/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Stearoyl-CoA Desaturase/genetics ; TOR Serine-Threonine Kinases/genetics

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Skocz do pozycji: 8.

Tytuł:: Whole Genome Sequencing of Familial Non-Medullary Thyroid Cancer Identifies Germline Alterations in MAPK/ERK and PI3K/AKT Signaling Pathways.
Autorzy:: Srivastava A; Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany. .; Hopp Children's Cancer Center (KiTZ), D-69120 Heidelberg, Germany. .; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), D-69120 Heidelberg, Germany. .; Medical Faculty, Heidelberg University, D-69120 Heidelberg, Germany. .
Kumar A; Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany. .; Institute of Bioinformatics, International Technology Park, Bangalore 560066, India. .; Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India. .
Giangiobbe S; Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany. .
Bonora E; S.Orsola-Malphigi Hospital, Unit of Medical Genetics, 40138 Bologna, Italy. .
Hemminki K; Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany. .
Försti A; Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany. .; Hopp Children's Cancer Center (KiTZ), D-69120 Heidelberg, Germany. .; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), D-69120 Heidelberg, Germany. .
Bandapalli OR; Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany. .; Hopp Children's Cancer Center (KiTZ), D-69120 Heidelberg, Germany. .; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), D-69120 Heidelberg, Germany. .; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2019 Oct 13; Vol. 9 (10). Date of Electronic Publication: 2019 Oct 13.
Typ publikacji:: Journal Article
MeSH Terms:: Extracellular Signal-Regulated MAP Kinases/*genetics
Mitogen-Activated Protein Kinase Kinases/*genetics
Phosphatidylinositol 3-Kinases/*genetics
Proto-Oncogene Proteins c-akt/*genetics
Signal Transduction/*genetics
Thyroid Cancer, Papillary/*genetics
Extracellular Signal-Regulated MAP Kinases/metabolism ; Female ; Germ-Line Mutation/genetics ; Humans ; Male ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Pedigree ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Thyroid Cancer, Papillary/blood

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Skocz do pozycji: 9.

Tytuł:: ERK is a Pivotal Player of Chemo-Immune-Resistance in Cancer.
Autorzy:: Salaroglio IC; Department of Oncology, University of Torino, via Santena 5/bis, 10126 Torino, Italy. .
Mungo E; Department of Oncology, University of Torino, via Santena 5/bis, 10126 Torino, Italy. .
Gazzano E; Department of Oncology, University of Torino, via Santena 5/bis, 10126 Torino, Italy. .
Kopecka J; Department of Oncology, University of Torino, via Santena 5/bis, 10126 Torino, Italy. .
Riganti C; Department of Oncology, University of Torino, via Santena 5/bis, 10126 Torino, Italy. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2019 May 21; Vol. 20 (10). Date of Electronic Publication: 2019 May 21.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Signal Transduction*
Extracellular Signal-Regulated MAP Kinases/*metabolism
Neoplasms/*metabolism
Animals ; Apoptosis ; Cell Differentiation ; Cell Proliferation ; Extracellular Signal-Regulated MAP Kinases/physiology ; Humans ; Neoplasms/physiopathology

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Skocz do pozycji: 10.

Tytuł:: K-RAS Acts as a Critical Regulator of CD44 to Promote the Invasiveness and Stemness of GBM in Response to Ionizing Radiation.
Autorzy:: Zhao Y; Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul 04763, Korea.
Kang JH; Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul 04763, Korea.
Yoo KC; Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul 04763, Korea.
Kang SG; Department of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.
Lee HJ; Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea.
Lee SJ; Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul 04763, Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Oct 10; Vol. 22 (20). Date of Electronic Publication: 2021 Oct 10.
Typ publikacji:: Journal Article
MeSH Terms:: Radiation, Ionizing*
Brain Neoplasms/*pathology
Glioblastoma/*pathology
Hyaluronan Receptors/*metabolism
Proto-Oncogene Proteins p21(ras)/*metabolism
Signal Transduction/*radiation effects
Brain Neoplasms/metabolism ; Brain Neoplasms/mortality ; Cell Line, Tumor ; Cell Movement/radiation effects ; Down-Regulation/drug effects ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Glioblastoma/metabolism ; Glioblastoma/mortality ; Humans ; Hyaluronan Receptors/antagonists & inhibitors ; Hyaluronan Receptors/genetics ; Kaplan-Meier Estimate ; MicroRNAs/metabolism ; Proto-Oncogene Proteins p21(ras)/genetics ; RNA Interference ; RNA, Small Interfering/metabolism

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Skocz do pozycji: 11.

Tytuł:: Cajanin Suppresses Melanin Synthesis through Modulating MITF in Human Melanin-Producing Cells.
Autorzy:: Netcharoensirisuk P; Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Umehara K; Faculty of Pharmaceutical Sciences, Yokohama University of Pharmacy, Kanagawa 2450066, Japan.
De-Eknamkul W; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Chaotham C; Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.; Cell-Based Drug and Health Products Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2021 Oct 05; Vol. 26 (19). Date of Electronic Publication: 2021 Oct 05.
Typ publikacji:: Journal Article
MeSH Terms:: Isoflavones/*pharmacology
Melanoma/*drug therapy
Melanoma/*metabolism
Microphthalmia-Associated Transcription Factor/*drug effects
Microphthalmia-Associated Transcription Factor/*metabolism
Signal Transduction/*drug effects
Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cyclic AMP Response Element-Binding Protein/metabolism ; Dalbergia/chemistry ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Hyperpigmentation/drug therapy ; Interferon Type I/metabolism ; Intramolecular Oxidoreductases/metabolism ; Isoflavones/chemistry ; Melanins/biosynthesis ; Melanocytes/drug effects ; Melanocytes/enzymology ; Melanocytes/metabolism ; Melanoma/enzymology ; Monophenol Monooxygenase/metabolism ; Plant Extracts/pharmacology ; Pregnancy Proteins/metabolism ; Quality of Life

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Skocz do pozycji: 12.

Tytuł:: Identification of a novel conserved signaling motif in CD200 receptor required for its inhibitory function.
Autorzy:: Timmerman LM; Department of Immunology, Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.
de Graaf JF; Department of Immunology, Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Satravelas N; Theoretical Biology & Bioinformatics, Science Faculty, Utrecht University, Utrecht, The Netherlands.
Kesmir Ç; Theoretical Biology & Bioinformatics, Science Faculty, Utrecht University, Utrecht, The Netherlands.
Meyaard L; Department of Immunology, Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.
van der Vlist M; Department of Immunology, Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2021 Mar 29; Vol. 16 (3), pp. e0244770. Date of Electronic Publication: 2021 Mar 29 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Signal Transduction*
Orexin Receptors/*metabolism
Amino Acid Motifs ; Animals ; Cell Line ; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Interleukin-8/metabolism ; Lipopolysaccharides/pharmacology ; Monocytes/cytology ; Monocytes/drug effects ; Monocytes/metabolism ; Mutagenesis, Site-Directed ; Orexin Receptors/chemistry ; Orexin Receptors/classification ; Orexin Receptors/genetics ; Phosphorylation ; Phylogeny ; Protein Domains ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/metabolism ; Tyrosine/metabolism

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Skocz do pozycji: 13.

Tytuł:: CSNK1G2 differently sensitizes tamoxifen-induced decrease in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen receptor existence in breast cancer cells.
Autorzy:: Nguyen Hoang AT; Department of Bioactive Material Sciences, Jeonbuk National University, Jeonju, Jeollabuk-do, Republic of Korea.
Hoe KL; Department of New Drug Discovery and Development, Chungnam National University, Daejeon, Republic of Korea.
Lee SJ; Department of Bioactive Material Sciences, Jeonbuk National University, Jeonju, Jeollabuk-do, Republic of Korea.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2021 Apr 16; Vol. 16 (4), pp. e0246264. Date of Electronic Publication: 2021 Apr 16 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents, Hormonal/*pharmacology
Breast Neoplasms/*drug therapy
Estrogen Receptor alpha/*metabolism
Signal Transduction/*drug effects
Tamoxifen/*pharmacology
Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Female ; Gene Knockdown Techniques ; Humans ; MCF-7 Cells ; Phosphatidylinositol 3-Kinase/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Ribosomal Protein S6 Kinases/metabolism ; TOR Serine-Threonine Kinases/metabolism

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Skocz do pozycji: 14.

Tytuł:: Signalling Pathways Mediating the Effects of CD40-Activated CD40L Reverse Signalling on Inhibitory Medium Spiny Neuron Neurite Growth.
Autorzy:: Carriba P; School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
Davies AM; School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.; Pokaż więcej
Źródło:: Cells [Cells] 2021 Apr 07; Vol. 10 (4). Date of Electronic Publication: 2021 Apr 07.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Signal Transduction*
CD40 Antigens/*metabolism
CD40 Ligand/*metabolism
Neurites/*metabolism
Animals ; CD40 Antigens/deficiency ; Cell Proliferation ; Cells, Cultured ; Extracellular Signal-Regulated MAP Kinases/metabolism ; GABAergic Neurons/metabolism ; JNK Mitogen-Activated Protein Kinases/metabolism ; Mice, Inbred C57BL ; Models, Biological ; Phosphorylation ; Protein Interaction Maps ; Protein Kinase C/metabolism ; Syk Kinase/metabolism ; Mice

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Skocz do pozycji: 15.

Tytuł:: CODEX, a neural network approach to explore signaling dynamics landscapes.
Autorzy:: Jacques MA; Institute of Cell Biology, University of Bern, Bern, Switzerland.
Dobrzyński M; Institute of Cell Biology, University of Bern, Bern, Switzerland.
Gagliardi PA; Institute of Cell Biology, University of Bern, Bern, Switzerland.
Sznitman R; ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland.
Pertz O; Institute of Cell Biology, University of Bern, Bern, Switzerland.; Pokaż więcej
Źródło:: Molecular systems biology [Mol Syst Biol] 2021 Apr; Vol. 17 (4), pp. e10026.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Algorithms*
Neural Networks, Computer*
Signal Transduction*
Animals ; Cell Line ; Databases as Topic ; Dose-Response Relationship, Radiation ; Drosophila/physiology ; Drosophila/radiation effects ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Fluorescent Dyes/metabolism ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; Light ; Machine Learning ; Movement/radiation effects ; Proto-Oncogene Proteins c-akt/metabolism ; Radiation, Ionizing ; Transforming Growth Factor beta/metabolism ; Tumor Suppressor Protein p53/metabolism

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Skocz do pozycji: 16.

Tytuł:: 4-Sulfonyloxy/alkoxy benzoxazolone derivatives with high anti-inflammatory activities: Synthesis, biological evaluation, and mechanims of action via p38/ERK-NF-κB/iNOS pathway.
Autorzy:: Tang L; School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, China.; Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation, Shanxi University of Traditional Chinese Medicine, Taiyuan, China.
Luo JR; School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, China.
Wang XY; School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, China.
Zhao B; School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, China.
Ge R; School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, China.
Liang TG; School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, China.
Ban SR; School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, China.
Li QS; School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, China.; Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation, Shanxi University of Traditional Chinese Medicine, Taiyuan, China.; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2021 Feb; Vol. 97 (2), pp. 200-209. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anti-Inflammatory Agents/*pharmacology
Benzoxazoles/*chemistry
Signal Transduction/*drug effects
Animals ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/therapeutic use ; Benzoxazoles/pharmacology ; Benzoxazoles/therapeutic use ; Binding Sites ; Down-Regulation/drug effects ; Edema/chemically induced ; Edema/drug therapy ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Lipopolysaccharides/pharmacology ; Macrophages/cytology ; Macrophages/drug effects ; Macrophages/metabolism ; Mice ; Molecular Docking Simulation ; NF-kappa B/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/chemistry ; Nitric Oxide Synthase Type II/metabolism ; RAW 264.7 Cells ; Structure-Activity Relationship ; Tumor Necrosis Factor-alpha/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism

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Skocz do pozycji: 17.

Tytuł:: α-Pinene Enhances the Anticancer Activity of Natural Killer Cells via ERK/AKT Pathway.
Autorzy:: Jo H; Department of Applied Biotechnology, Ajou University, Suwon 16499, Korea.
Cha B; Department of Biological Sciences, Ajou University, Suwon 16499, Korea.
Kim H; Department of Biological Sciences, Ajou University, Suwon 16499, Korea.
Brito S; Department of Applied Biotechnology, Ajou University, Suwon 16499, Korea.
Kwak BM; Department of Meridian and Acupoint, College of Korean Medicine, Semyung University, Chungbuk 27136, Korea.; School of Cosmetic Science and Beauty Biotechnology, Semyung University, 65 Semyung-ro, Jecheon-si, Chungcheongbuk-do 27136, Korea.
Kim ST; Department of Pharmaceutical Engineering, Inje University, Gimhae-si, Gyeongsangnam-do 50834, Korea.; Department of Nanoscience and Engineering, Inje University, Gimhae-si, Gyeongsangnam-do 50834, Korea.
Bin BH; Department of Applied Biotechnology, Ajou University, Suwon 16499, Korea.; Department of Biological Sciences, Ajou University, Suwon 16499, Korea.
Lee MG; Bio-Center, Gyeonggido Business and Science Accelerator, Suwon 16229, Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jan 11; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 11.
Typ publikacji:: Journal Article
MeSH Terms:: Bicyclic Monoterpenes/*pharmacology
Extracellular Signal-Regulated MAP Kinases/*metabolism
Killer Cells, Natural/*drug effects
Killer Cells, Natural/*immunology
Killer Cells, Natural/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Signal Transduction/*drug effects
Animals ; Cell Line, Tumor ; Cytotoxicity, Immunologic ; Disease Models, Animal ; Humans ; Lymphocyte Activation/immunology ; Mice ; Mice, Inbred BALB C ; Neoplasms/immunology ; Neoplasms/metabolism ; Xenograft Model Antitumor Assays

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Skocz do pozycji: 18.

Tytuł:: Involvement of the ERK/HIF-1α/EMT Pathway in XCL1-Induced Migration of MDA-MB-231 and SK-BR-3 Breast Cancer Cells.
Autorzy:: Do HTT; College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Dongguk-ro 32, Ilsandong-gu, Goyang, Gyeonggi 10326, Korea.
Cho J; College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, Dongguk-ro 32, Ilsandong-gu, Goyang, Gyeonggi 10326, Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Dec 23; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 23.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Movement*
Signal Transduction*
Breast Neoplasms/*metabolism
Chemokines, C/*metabolism
A549 Cells ; Epithelial-Mesenchymal Transition ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Female ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Receptors, G-Protein-Coupled/metabolism

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Skocz do pozycji: 19.

Tytuł:: PHD2 acts as an oncogene through activation of Ras/Raf/MEK/ERK and JAK1/STAT3 pathways in human hepatocellular carcinoma cells.
Autorzy:: Guo J; Department of Trauma Emergency, Huaihe Hospital, Henan University, Kaifeng, China.
Lan Z; Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Pokaż więcej
Źródło:: Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 37-45.
Typ publikacji:: Journal Article; Retracted Publication
MeSH Terms:: Signal Transduction*
Carcinoma, Hepatocellular/*pathology
Hypoxia-Inducible Factor-Proline Dioxygenases/*genetics
Liver Neoplasms/*pathology
Oncogenes/*genetics
Cell Movement ; Cell Proliferation ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Janus Kinase 1/metabolism ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Neoplasm Invasiveness ; STAT3 Transcription Factor/metabolism ; raf Kinases/metabolism ; ras Proteins/metabolism

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Skocz do pozycji: 20.

Tytuł:: Activation of CXCL12-CXCR4 signalling induces conversion of immortalised embryonic kidney cells into cancer stem-like cells.
Autorzy:: Oh SI; School of Biosystems and Biomedical Sciences, College of Health Science, Korea University, Seoul, Republic of Korea.
Jeong H; School of Biosystems and Biomedical Sciences, College of Health Science, Korea University, Seoul, Republic of Korea.; Department of Public Health Science, College of Health Science, Korea University, Seoul, Republic of Korea.
Park HS; School of Biosystems and Biomedical Sciences, College of Health Science, Korea University, Seoul, Republic of Korea.
Choi KA; School of Biosystems and Biomedical Sciences, College of Health Science, Korea University, Seoul, Republic of Korea.
Hwang I; School of Biosystems and Biomedical Sciences, College of Health Science, Korea University, Seoul, Republic of Korea.
Lee J; Department of Pathology, College of Medicine, Korea University, Seoul, Republic of Korea.
Cho J; Department of Nanobiomedical Science, Dankook University, Cheonan, Republic of Korea.
Hong S; School of Biosystems and Biomedical Sciences, College of Health Science, Korea University, Seoul, Republic of Korea.; Department of Public Health Science, College of Health Science, Korea University, Seoul, Republic of Korea.; Pokaż więcej
Źródło:: Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 1303-1313.
Typ publikacji:: Journal Article
MeSH Terms:: Signal Transduction*
Chemokine CXCL12/*metabolism
Neoplastic Stem Cells/*pathology
Receptors, CXCR4/*metabolism
Animals ; Carcinogenesis ; Extracellular Signal-Regulated MAP Kinases/metabolism ; HEK293 Cells ; Humans ; Mice ; ets-Domain Protein Elk-1/metabolism

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