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Wyszukujesz frazę ""Eye Proteins"" wg kryterium: Temat


Tytuł :
SWATH Based Quantitative Proteomics Reveals Significant Lipid Metabolism in Early Myopic Guinea Pig Retina.
Autorzy :
Bian J; Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
Sze YH; Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
Tse DY; Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.; Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong, China.
To CH; Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.; Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong, China.
McFadden SA; School of Psychology, College of Engineering, Science and the Environment, University of Newcastle, Callaghan, NSW 2308, Australia.
Lam CS; Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.; Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong, China.
Li KK; Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
Lam TC; Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.; Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong, China.; Shenzhen Research Institute, The Hong Kong Polytechnic University, Shenzhen 518052, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 29; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 29.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Eye Proteins/*biosynthesis
Myopia/*metabolism
Proteomics/*methods
Retina/*metabolism
Tandem Mass Spectrometry/*methods
Animals ; Computational Biology ; Datasets as Topic ; Disease Models, Animal ; Eye Proteins/genetics ; Gene Expression Regulation ; Gene Ontology ; Gene Regulatory Networks ; Guinea Pigs ; Lipid Metabolism ; Metabolic Networks and Pathways/genetics ; Software
Czasopismo naukowe
Tytuł :
Pigment Epithelium-Derived Factor Enhances the Suppressive Phenotype of Regulatory T Cells in a Murine Model of Dry Eye Disease.
Autorzy :
Singh RB; Laboratory of Corneal Immunology, Transplantation and Regeneration, Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Blanco T; Laboratory of Corneal Immunology, Transplantation and Regeneration, Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Mittal SK; Laboratory of Corneal Immunology, Transplantation and Regeneration, Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Alemi H; Laboratory of Corneal Immunology, Transplantation and Regeneration, Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Chauhan SK; Laboratory of Corneal Immunology, Transplantation and Regeneration, Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Chen Y; Laboratory of Corneal Immunology, Transplantation and Regeneration, Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Dana R; Laboratory of Corneal Immunology, Transplantation and Regeneration, Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts. Electronic address: .
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Źródło :
The American journal of pathology [Am J Pathol] 2021 Apr; Vol. 191 (4), pp. 720-729. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Dry Eye Syndromes/*drug therapy
Eye Proteins/*pharmacology
Nerve Growth Factors/*pharmacology
Serpins/*pharmacology
T-Lymphocytes, Regulatory/*drug effects
Th17 Cells/*drug effects
Animals ; Antigen-Presenting Cells/drug effects ; Cytokines/genetics ; Disease Models, Animal ; Eye Proteins/metabolism ; Female ; Mice, Inbred C57BL ; Nerve Growth Factors/metabolism ; Phenotype ; Serpins/metabolism
Czasopismo naukowe
Tytuł :
pH-dependence of signaling-state formation in Drosophila cryptochrome.
Autorzy :
Einholz C; Institut für Physikalische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstraße 21, 79104, Freiburg, Germany.
Nohr D; Institut für Physikalische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstraße 21, 79104, Freiburg, Germany.
Rodriguez R; Institut für Physikalische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstraße 21, 79104, Freiburg, Germany.
Topitsch A; Institut für Physikalische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstraße 21, 79104, Freiburg, Germany.
Kern M; Institut für Physikalische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstraße 21, 79104, Freiburg, Germany.
Goldmann J; Institut für Physikalische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstraße 21, 79104, Freiburg, Germany.
Chileshe E; Institut für Physikalische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstraße 21, 79104, Freiburg, Germany.
Okasha M; Institut für Physikalische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstraße 21, 79104, Freiburg, Germany.
Weber S; Institut für Physikalische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstraße 21, 79104, Freiburg, Germany.
Schleicher E; Institut für Physikalische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstraße 21, 79104, Freiburg, Germany. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Mar 30; Vol. 700, pp. 108787. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Substitution*
Mutation, Missense*
Cryptochromes/*chemistry
Drosophila Proteins/*chemistry
Eye Proteins/*chemistry
Animals ; Cryptochromes/genetics ; Cryptochromes/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Eye Proteins/genetics ; Eye Proteins/metabolism ; Hydrogen-Ion Concentration ; Oxidation-Reduction ; Protein Stability
Czasopismo naukowe
Tytuł :
Knockdown of FAM225B inhibits the progression of the hypertrophic scar following glaucoma surgery by inhibiting autophagy.
Autorzy :
Ma X; Department of Dermatology, Affiliated Hospital of Beihua University, Jilin, Jilin 132001, P.R. China.
Liu L; Department of Dermatology, Affiliated Hospital of Beihua University, Jilin, Jilin 132001, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Mar; Vol. 23 (3). Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*
Eye Proteins*/genetics
Eye Proteins*/metabolism
Cicatrix, Hypertrophic/*metabolism
Fibroblasts/*metabolism
Glaucoma/*metabolism
Neoplasm Proteins/*deficiency
Cells, Cultured ; Cicatrix, Hypertrophic/genetics ; Cicatrix, Hypertrophic/pathology ; Female ; Fibroblasts/pathology ; Gene Knockout Techniques ; Glaucoma/genetics ; Glaucoma/pathology ; Glaucoma/surgery ; Humans ; Middle Aged ; Neoplasm Proteins/metabolism
Czasopismo naukowe
Tytuł :
Upregulation of microRNA‑140‑3p mediates dachshund family transcription factor 1 expression in immunoglobulin A nephropathy through cell cycle‑dependent mechanisms.
Autorzy :
Zhou X; Department of Clinical Laboratory, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China.
Lu Y; Department of Teaching Research of Medical Technology, Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China.
Guo P; Department of Clinical Laboratory, Shanghai Tenth People's Hospital, Shanghai 200072, P.R. China.
Zhou C; Department of Clinical Laboratory, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 Feb; Vol. 23 (2). Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Cycle/*genetics
Eye Proteins/*biosynthesis
Glomerulonephritis, IGA/*genetics
Glomerulonephritis, IGA/*metabolism
MicroRNAs/*genetics
MicroRNAs/*metabolism
Transcription Factors/*biosynthesis
3' Untranslated Regions ; Adult ; Cell Proliferation/genetics ; Cells, Cultured ; Computational Biology ; Cytokines/metabolism ; Eye Proteins/genetics ; Eye Proteins/physiology ; Female ; Glomerulonephritis, IGA/blood ; Humans ; Immunoglobulin A/isolation & purification ; Immunoglobulin A/pharmacology ; Male ; Mesangial Cells/metabolism ; MicroRNAs/antagonists & inhibitors ; Transcription Factors/genetics ; Transcription Factors/physiology ; Up-Regulation ; Young Adult
Czasopismo naukowe
Tytuł :
Ethacrynic acid, a loop diuretic, suppresses epithelial-mesenchymal transition of A549 lung cancer cells via blocking of NDP-induced WNT signaling.
Autorzy :
Yu L; College of Pharmacy, Dongguk University, Seoul 100-715, Republic of Korea.
Kim HJ; College of Pharmacy, Dongguk University, Seoul 100-715, Republic of Korea.
Park MK; National Cancer Center, Goyang 10408, Republic of Korea.
Byun HJ; College of Pharmacy, Dongguk University, Seoul 100-715, Republic of Korea.
Kim EJ; College of Pharmacy, Dongguk University, Seoul 100-715, Republic of Korea.
Kim B; College of Pharmacy, Dongguk University, Seoul 100-715, Republic of Korea.
Nguyen MT; College of Pharmacy, Dongguk University, Seoul 100-715, Republic of Korea.
Kim JH; College of Pharmacy, Dongguk University, Seoul 100-715, Republic of Korea.
Kang GJ; Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, USA.
Lee H; National Cancer Center, Goyang 10408, Republic of Korea.
Kim SY; National Cancer Center, Goyang 10408, Republic of Korea.
Rho SB; National Cancer Center, Goyang 10408, Republic of Korea. Electronic address: .
Lee CH; College of Pharmacy, Dongguk University, Seoul 100-715, Republic of Korea. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Jan; Vol. 183, pp. 114339. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epithelial-Mesenchymal Transition/*drug effects
Ethacrynic Acid/*pharmacology
Eye Proteins/*pharmacology
Lung Neoplasms/*metabolism
Nerve Tissue Proteins/*pharmacology
Sodium Potassium Chloride Symporter Inhibitors/*pharmacology
Wnt Signaling Pathway/*drug effects
A549 Cells ; Animals ; Cell Movement/drug effects ; Cell Movement/physiology ; Dose-Response Relationship, Drug ; Epithelial-Mesenchymal Transition/physiology ; Ethacrynic Acid/therapeutic use ; Eye Proteins/antagonists & inhibitors ; Eye Proteins/biosynthesis ; Humans ; Lung Neoplasms/drug therapy ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Nerve Tissue Proteins/antagonists & inhibitors ; Nerve Tissue Proteins/biosynthesis ; RNA, Small Interfering/pharmacology ; Sodium Potassium Chloride Symporter Inhibitors/therapeutic use ; Wnt Signaling Pathway/physiology
Czasopismo naukowe
Tytuł :
The Major Ciliary Isoforms of RPGR Build Different Interaction Complexes with INPP5E and RPGRIP1L.
Autorzy :
Vössing C; Human Genetics, Faculty VI-School of Medicine and Health Sciences, University of Oldenburg, 26129 Oldenburg, Germany.
Atigbire P; Human Genetics, Faculty VI-School of Medicine and Health Sciences, University of Oldenburg, 26129 Oldenburg, Germany.
Eilers J; Human Genetics, Faculty VI-School of Medicine and Health Sciences, University of Oldenburg, 26129 Oldenburg, Germany.
Markus F; Junior Research Group, Genetics of Childhood Brain Malformations, Faculty VI-School of Medicine and Health Sciences, University of Oldenburg, 26129 Oldenburg, Germany.
Stieger K; Department of Ophthalmology, Justus-Liebig-University Giessen, 35390 Giessen, Germany.
Song F; Human Genetics, Faculty VI-School of Medicine and Health Sciences, University of Oldenburg, 26129 Oldenburg, Germany.
Neidhardt J; Human Genetics, Faculty VI-School of Medicine and Health Sciences, University of Oldenburg, 26129 Oldenburg, Germany.; Research Center Neurosensory Science, University of Oldenburg, 26129 Oldenburg, Germany.; Joint Research Training Group of the Faculty of Medicine and Health Sciences, University of Oldenburg, Germany and the University Medical Center Groningen, 9700 Groningen, The Netherlands.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 30; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 30.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Eye Proteins/*genetics
Phosphoric Monoester Hydrolases/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Alternative Splicing/genetics ; Binding Sites ; Cilia/genetics ; Cilia/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 6/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 6/metabolism ; Exons/genetics ; Eye Proteins/metabolism ; HEK293 Cells ; Humans ; Mutation/genetics ; Phosphoric Monoester Hydrolases/genetics ; Protein Isoforms/genetics ; RNA Splicing/genetics ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/metabolism
Czasopismo naukowe
Tytuł :
Identification of a novel GPR143 mutation in a large Chinese family with isolated foveal hypoplasia.
Autorzy :
Mao X; Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Chen M; Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Yu Y; Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Liu Q; Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Yuan S; Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Fan W; Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. .
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Źródło :
BMC ophthalmology [BMC Ophthalmol] 2021 Mar 30; Vol. 21 (1), pp. 156. Date of Electronic Publication: 2021 Mar 30.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Eye Proteins*/genetics
Membrane Glycoproteins*/genetics
China ; Humans ; Mutation ; Pedigree
Czasopismo naukowe
Tytuł :
Extending the phenotypic spectrum of PRPF8, PRPH2, RP1 and RPGR, and the genotypic spectrum of early-onset severe retinal dystrophy.
Autorzy :
Georgiou M; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.; Moorfields Eye Hospital, London, UK.
Ali N; Moorfields Eye Hospital, London, UK.
Yang E; Moorfields Eye Hospital, London, UK.
Grewal PS; Moorfields Eye Hospital, London, UK.
Rotsos T; First Division of Ophthalmology, General Hospital of Athens, National and Kapodistrian University of Athens, Athens, Greece.
Pontikos N; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.; Moorfields Eye Hospital, London, UK.
Robson AG; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.; Moorfields Eye Hospital, London, UK.
Michaelides M; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK. .; Moorfields Eye Hospital, London, UK. .
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Źródło :
Orphanet journal of rare diseases [Orphanet J Rare Dis] 2021 Mar 12; Vol. 16 (1), pp. 128. Date of Electronic Publication: 2021 Mar 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Eye Proteins*/genetics
Retinal Dystrophies*/genetics
Humans ; Infant ; Microtubule-Associated Proteins ; Mutation/genetics ; Pedigree ; Phenotype ; RNA-Binding Proteins ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Effect of Mindfulness Meditation on Intraocular Pressure and Trabecular Meshwork Gene Expression: A Randomized Controlled Trial.
Autorzy :
Dada T; Dr. Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. Electronic address: .
Bhai N; Dr. Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Midha N; Dr. Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Shakrawal J; Dr. Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Kumar M; Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.
Chaurasia P; Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.
Gupta S; Dr. Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Angmo D; Dr. Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Yadav R; Integrated Health Clinic, Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.
Dada R; Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.
Sihota R; Dr. Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
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Źródło :
American journal of ophthalmology [Am J Ophthalmol] 2021 Mar; Vol. 223, pp. 308-321. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression*
Eye Proteins/*genetics
Glaucoma, Open-Angle/*therapy
Intraocular Pressure/*physiology
Meditation/*methods
Mindfulness/*methods
Trabecular Meshwork/*metabolism
Eye Proteins/biosynthesis ; Female ; Follow-Up Studies ; Glaucoma, Open-Angle/genetics ; Glaucoma, Open-Angle/metabolism ; Humans ; Male ; Middle Aged ; Quality of Life ; Retrospective Studies ; Single-Blind Method
Czasopismo naukowe
Tytuł :
Tissue- and isoform-specific protein complex analysis with natively processed bait proteins.
Autorzy :
Beyer T; Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Elfriede-Aulhorn-Strasse 7, D-72076 Tuebingen, Germany.
Klose F; Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Elfriede-Aulhorn-Strasse 7, D-72076 Tuebingen, Germany.
Kuret A; Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tuebingen, Auf der Morgenstelle 8, D-72076 Tuebingen, Germany.
Hoffmann F; Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Elfriede-Aulhorn-Strasse 7, D-72076 Tuebingen, Germany.
Lukowski R; Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tuebingen, Auf der Morgenstelle 8, D-72076 Tuebingen, Germany.
Ueffing M; Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Elfriede-Aulhorn-Strasse 7, D-72076 Tuebingen, Germany. Electronic address: .
Boldt K; Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Elfriede-Aulhorn-Strasse 7, D-72076 Tuebingen, Germany. Electronic address: .
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Źródło :
Journal of proteomics [J Proteomics] 2021 Jan 16; Vol. 231, pp. 103947. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Eye Proteins*
Microtubule-Associated Proteins*
Animals ; HEK293 Cells ; Humans ; Immunoprecipitation ; Membrane Proteins ; Mice ; Protein Isoforms ; Swine
Czasopismo naukowe
Tytuł :
Biochemical and biomechanical characteristics of dystrophin-deficient mdx mouse lens.
Autorzy :
Karnam S; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.
Skiba NP; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.
Rao PV; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2021 Jan 01; Vol. 1867 (1), pp. 165998. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression Regulation*
Dystrophin/*deficiency
Eye Proteins/*biosynthesis
Lens, Crystalline/*metabolism
Animals ; Dystrophin/metabolism ; Eye Proteins/genetics ; Mice ; Mice, Inbred mdx
Czasopismo naukowe
Tytuł :
GUCY2D mutations in retinal guanylyl cyclase 1 provide biochemical reasons for dominant cone-rod dystrophy but not for stationary night blindness.
Autorzy :
Peshenko IV; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania, USA.
Olshevskaya EV; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania, USA.
Dizhoor AM; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Dec 25; Vol. 295 (52), pp. 18301-18315. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Calcium/*metabolism
Cone-Rod Dystrophies/*genetics
Eye Proteins/*metabolism
Guanylate Cyclase/*metabolism
Night Blindness/*genetics
Receptors, Cell Surface/*metabolism
Amino Acid Substitution ; Eye Proteins/chemistry ; Eye Proteins/genetics ; Guanylate Cyclase/chemistry ; Guanylate Cyclase/genetics ; HEK293 Cells ; Humans ; Protein Conformation ; Protein Multimerization ; Receptors, Cell Surface/chemistry ; Receptors, Cell Surface/genetics
Czasopismo naukowe
Tytuł :
CCDC66 frameshift variant associated with a new form of early-onset progressive retinal atrophy in Portuguese Water Dogs.
Autorzy :
Murgiano L; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Becker D; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute of Genome Biology, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany.
Spector C; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Carlin K; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Santana E; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Niggel JK; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jagannathan V; Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Leeb T; Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Pearce-Kelling S; Optigen, LLC, Ithaca, NY, USA.
Aguirre GD; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Miyadera K; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Dec 03; Vol. 10 (1), pp. 21162. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Eye Proteins/*genetics
Frameshift Mutation/*genetics
Retinal Degeneration/*genetics
Amino Acid Sequence ; Animals ; Atrophy ; Base Sequence ; Cell Nucleus/metabolism ; Chromosome Mapping ; Dogs ; Eye Proteins/chemistry ; Eye Proteins/metabolism ; Female ; Fundus Oculi ; Male ; Molecular Sequence Annotation ; Mutant Proteins ; Pedigree ; Phenotype ; Portugal ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Retina/metabolism ; Retina/pathology
Czasopismo naukowe
Tytuł :
Trehalose Inhibits the Heat-Induced Formation of the Amyloid-Like Structure of Soluble Proteins Isolated from Human Cataract Lens.
Autorzy :
Ram L; Department of Biotechnology, Central University of Rajasthan, NH-8 Bandersindri, Kishangarh, Ajmer, Rajasthan, 305817, India.
Mittal C; Department of Biotechnology, Central University of Rajasthan, NH-8 Bandersindri, Kishangarh, Ajmer, Rajasthan, 305817, India.
Harsolia RS; Department of Ophthalmology, Jawaharlal Nehru Medical College, Ajmer, Rajasthan, India.
Yadav JK; Department of Biotechnology, Central University of Rajasthan, NH-8 Bandersindri, Kishangarh, Ajmer, Rajasthan, 305817, India. .
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Źródło :
The protein journal [Protein J] 2020 Oct; Vol. 39 (5), pp. 509-518. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid*/chemistry
Amyloid*/isolation & purification
Cataract*
Eye Proteins*/chemistry
Eye Proteins*/isolation & purification
Hot Temperature*
Protein Aggregates*
Lens, Crystalline/*chemistry
Humans ; Solubility
Czasopismo naukowe
Tytuł :
Circular RNA CCDC66 facilitates abdominal aortic aneurysm through the overexpression of CCDC66.
Autorzy :
Yang R; Department of Vascular Surgery, The Fifth Hospital of Wuhan, Wuhan, People's Republic of China.
Wang Z; Department of Vascular Surgery, The Fifth Hospital of Wuhan, Wuhan, People's Republic of China.
Meng G; Department of Vascular Surgery, The Fifth Hospital of Wuhan, Wuhan, People's Republic of China.
Hua L; Medical Examination Center, The Fifth Hospital of Wuhan, Wuhan, People's Republic of China.
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Źródło :
Cell biochemistry and function [Cell Biochem Funct] 2020 Oct; Vol. 38 (7), pp. 830-838. Date of Electronic Publication: 2020 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Eye Proteins/*metabolism
RNA, Circular/*metabolism
Aortic Aneurysm, Abdominal/genetics ; Aortic Aneurysm, Abdominal/pathology ; Apoptosis ; Base Sequence ; Cell Line ; Cell Proliferation ; Eye Proteins/antagonists & inhibitors ; Eye Proteins/genetics ; Humans ; MicroRNAs/chemistry ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/metabolism ; RNA Interference ; RNA, Circular/antagonists & inhibitors ; RNA, Circular/genetics ; RNA, Small Interfering/metabolism ; Sequence Alignment ; Up-Regulation
Czasopismo naukowe
Tytuł :
Pigment Epithelium-Derived Factor (PEDF) Receptors Are Involved in Survival of Retinal Neurons.
Autorzy :
Bürger S; Department of Ophthalmology and Eye Hospital, Leipzig University, Liebigstrasse 10-14, D-04103 Leipzig, Germany.
Meng J; Department of Ophthalmology and Eye Hospital, Leipzig University, Liebigstrasse 10-14, D-04103 Leipzig, Germany.
Zwanzig A; Department of Ophthalmology and Eye Hospital, Leipzig University, Liebigstrasse 10-14, D-04103 Leipzig, Germany.
Beck M; Department of Ophthalmology and Eye Hospital, Leipzig University, Liebigstrasse 10-14, D-04103 Leipzig, Germany.
Pankonin M; Department of Ophthalmology and Eye Hospital, Leipzig University, Liebigstrasse 10-14, D-04103 Leipzig, Germany.
Wiedemann P; Department of Ophthalmology and Eye Hospital, Leipzig University, Liebigstrasse 10-14, D-04103 Leipzig, Germany.
Eichler W; Department of Ophthalmology and Eye Hospital, Leipzig University, Liebigstrasse 10-14, D-04103 Leipzig, Germany.
Unterlauft JD; Department of Ophthalmology and Eye Hospital, Leipzig University, Liebigstrasse 10-14, D-04103 Leipzig, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 31; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Journal Article
MeSH Terms :
Neuroprotection*
Eye Proteins/*metabolism
Nerve Growth Factors/*metabolism
Receptors, Laminin/*metabolism
Receptors, Neuropeptide/*metabolism
Retinal Ganglion Cells/*cytology
Retinal Neurons/*cytology
Serpins/*metabolism
Animals ; Cells, Cultured ; Eye Proteins/genetics ; Mice ; Nerve Growth Factors/genetics ; Receptors, Laminin/genetics ; Receptors, Neuropeptide/genetics ; Retinal Ganglion Cells/metabolism ; Retinal Neurons/metabolism ; Serpins/genetics
Czasopismo naukowe
Tytuł :
Elucidating the framework for specification and determination of the embryonic retina.
Autorzy :
Louie SH; Department of Biology, University of Virginia, Charlottesville, VA, 22904, USA.
Fisher M; Department of Biology, University of Virginia, Charlottesville, VA, 22904, USA.
Grainger RM; Department of Biology, University of Virginia, Charlottesville, VA, 22904, USA. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2020 Dec 15; Vol. 397 (2), pp. 112316. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Gene Expression Regulation, Developmental*
Embryo, Nonmammalian/*cytology
Eye Proteins/*metabolism
Retina/*embryology
Stem Cells/*cytology
Xenopus laevis/*embryology
Animals ; Cell Differentiation ; Embryo, Nonmammalian/metabolism ; Eye Proteins/genetics ; Xenopus laevis/metabolism
Czasopismo naukowe
Tytuł :
Dihydromyricetin promotes longevity and activates the transcription factors FOXO and AOP in Drosophila .
Autorzy :
Fan X; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, China.
Zeng Y; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Fan Z; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Cui L; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Song W; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Wu Q; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Gao Y; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Yang D; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, China.
Mao X; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, China.
Zeng B; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, China.
Zhang M; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, China.
Ni Q; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, China.
Li Y; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, China.
Wang T; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, China.
Li D; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, China.
Yang M; Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.; Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, China.
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Źródło :
Aging [Aging (Albany NY)] 2020 Dec 03; Vol. 13 (1), pp. 460-476. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging/*drug effects
Drosophila Proteins/*drug effects
Eye Proteins/*drug effects
Flavonols/*pharmacology
Forkhead Transcription Factors/*drug effects
Longevity/*drug effects
Repressor Proteins/*drug effects
Aging/metabolism ; Animals ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Eye Proteins/metabolism ; Forkhead Transcription Factors/metabolism ; Repressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
TRIM27 acts as an oncogene and regulates cell proliferation and metastasis in non-small cell lung cancer through SIX3-β-catenin signaling.
Autorzy :
Liu S; Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Tian Y; Xi'an Jiaotong University Press, Xi'an 710049, China.
Zheng Y; Xi'an Jiaotong University School of Medicine, Xi'an 710061, China.
Cheng Y; Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Zhang D; Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Jiang J; Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Li S; Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
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Źródło :
Aging [Aging (Albany NY)] 2020 Dec 02; Vol. 12 (24), pp. 25564-25580. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*genetics
Cell Proliferation/*genetics
DNA-Binding Proteins/*genetics
Eye Proteins/*genetics
Homeodomain Proteins/*genetics
Lung Neoplasms/*genetics
Nerve Tissue Proteins/*genetics
Nuclear Proteins/*genetics
A549 Cells ; Calcium-Binding Proteins/drug effects ; Calcium-Binding Proteins/metabolism ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Movement/drug effects ; Cell Movement/genetics ; Cell Proliferation/drug effects ; DNA-Binding Proteins/metabolism ; Eye Proteins/metabolism ; Female ; Heterocyclic Compounds, 3-Ring/pharmacology ; Homeodomain Proteins/metabolism ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Matrix Metalloproteinase 9/drug effects ; Matrix Metalloproteinase 9/metabolism ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Proteins/drug effects ; Neoplasm Proteins/metabolism ; Nerve Tissue Proteins/metabolism ; Nuclear Proteins/metabolism ; Oncogenes ; Signal Transduction ; Transforming Growth Factor beta3/drug effects ; Transforming Growth Factor beta3/metabolism ; Ubiquitination/drug effects ; Ubiquitination/genetics ; beta Catenin/drug effects ; beta Catenin/metabolism
Czasopismo naukowe

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