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Tytuł :
The "Dextran-Magnetic Layered Double Hydroxide-Fluorouracil" Drug Delivery System Exerts Its Anti-tumor Effect by Inducing Lysosomal Membrane Permeability in the Process of Cell Death.
Autorzy :
Shu C; Department of Pharmaceutics, College of Pharmacy, Ningxia Medical University.
Wang R; Department of Pharmacology, Key Laboratory of Ministry of Education in Fertility Preservation and Maintenance, Ningxia Medical University.
Zhang X; Department of Stomatology, People's Hospital of Longde.
Wen H; Department of Pharmaceutics, College of Pharmacy, Ningxia Medical University.
Tian Z; Department of Pharmaceutics, College of Pharmacy, Ningxia Medical University.
Wu X; Department of Pharmaceutics, College of Pharmacy, Ningxia Medical University.
Yang J; Department of Pharmaceutics, College of Pharmacy, Ningxia Medical University.
Gou G; Department of Pharmaceutics, College of Pharmacy, Ningxia Medical University.; Medical Chemistry Department, School of Basic Medical, Ningxia Medical University.
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Źródło :
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2021 Oct 01; Vol. 44 (10), pp. 1473-1483. Date of Electronic Publication: 2021 Jul 20.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Antineoplastic Agents/*administration & dosage
Cell Death/*drug effects
Fluorouracil/*administration & dosage
Lysosomes/*metabolism
Adenocarcinoma/drug therapy ; Antineoplastic Agents/therapeutic use ; Azure Stains ; Blotting, Western ; Cell Line, Tumor ; Dextrans ; Fluorescent Antibody Technique ; Fluorouracil/therapeutic use ; Humans ; Lymphatic Metastasis/drug therapy ; Magnetic Iron Oxide Nanoparticles ; Microscopy, Electron, Transmission ; Permeability ; Stomach Neoplasms/drug therapy
Czasopismo naukowe
Tytuł :
Theoretical Encapsulation of Fluorouracil (5-FU) Anti-Cancer Chemotherapy Drug into Carbon Nanotubes (CNT) and Boron Nitride Nanotubes (BNNT).
Autorzy :
Zarghami Dehaghani M; Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran 11155-4563, Iran.
Yousefi F; Department of Physics, University of Zanjan, Zanjan 45195-313, Iran.
Sajadi SM; Department of Nutrition, Cihan University-Erbil, Kurdistan Region, Erbil P.O. Box 625, Iraq.; Department of Phytochemistry, SRC, Soran University, Soran P.O. Box 624, Iraq.
Tajammal Munir M; College of Engineering and Technology, American University of the Middle East, Egaila 54200, Kuwait.
Abida O; College of Engineering and Technology, American University of the Middle East, Egaila 54200, Kuwait.
Habibzadeh S; Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran 1591639675, Iran.
Mashhadzadeh AH; Mechanical and Aerospace Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Nur-Sultan 010000, Kazakhstan.
Rabiee N; Department of Physics, Sharif University of Technology, Tehran P.O. Box 11155-9161, Iran.
Mostafavi E; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Saeb MR; Department of Polymer Technology, Faculty of Chemistry, Gdańsk University of Technology, G. Narutowicza 11/12, 80-233 Gdańsk, Poland.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 13; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 13.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Compounding*
Antineoplastic Agents/*pharmacology
Boron Compounds/*chemistry
Fluorouracil/*pharmacology
Nanotubes, Carbon/*chemistry
Drug Stability ; Fluorouracil/chemistry ; Molecular Conformation ; Molecular Dynamics Simulation ; Thermodynamics
Czasopismo naukowe
Tytuł :
Therapeutic Effects of GGsTop Gel in a Mouse Model of 5-Fluorouracil-induced Oral Mucositis With Reduced White Blood Cells.
Autorzy :
Takeuchi I; Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan; .; Center for Drug Delivery Research, Tokyo University of Science, Chiba, Japan.
Tanaka K; Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Makino K; Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.; Center for Drug Delivery Research, Tokyo University of Science, Chiba, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Sep; Vol. 41 (9), pp. 4313-4319.
Typ publikacji :
Journal Article
MeSH Terms :
Aminobutyrates/*administration & dosage
Antimetabolites, Antineoplastic/*adverse effects
Fluorouracil/*adverse effects
Leukocytes/*drug effects
Organophosphonates/*administration & dosage
Stomatitis/*drug therapy
Aminobutyrates/pharmacology ; Animals ; Antimetabolites, Antineoplastic/administration & dosage ; Body Weight/drug effects ; Collagen/metabolism ; Disease Models, Animal ; Drug Dosage Calculations ; Fluorouracil/administration & dosage ; Gels ; Glutathione/metabolism ; Male ; Mice ; Organophosphonates/pharmacology ; Stomatitis/chemically induced ; Stomatitis/metabolism
Czasopismo naukowe
Tytuł :
Capecitabine Treatment: A Safe and Effective Therapy in the Field of Oncology.
Autorzy :
Beenet L; Department of Pathology & Laboratory Medicine, Technology Center for Genomics & Bioinformatics, University of California, Los Angeles, Los Angeles, CA. Electronic address: .
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Źródło :
Clinical colorectal cancer [Clin Colorectal Cancer] 2021 Sep; Vol. 20 (3), pp. e194. Date of Electronic Publication: 2021 Apr 10.
Typ publikacji :
Letter; Comment
MeSH Terms :
Deoxycytidine*/adverse effects
Fluorouracil*/adverse effects
Capecitabine/adverse effects ; Humans ; Medical Oncology
Opinia redakcyjna
Tytuł :
Hospitalizations among early-stage colon cancer patients receiving adjuvant chemotherapy: a real-world study.
Autorzy :
Abdel-Rahman O; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada. .
Tang PA; Department of Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada.
Koski S; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.
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Źródło :
International journal of colorectal disease [Int J Colorectal Dis] 2021 Sep; Vol. 36 (9), pp. 1905-1913. Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article
MeSH Terms :
Colonic Neoplasms*/drug therapy
Colonic Neoplasms*/pathology
Fluorouracil*/therapeutic use
Aged ; Antineoplastic Combined Chemotherapy Protocols ; Chemotherapy, Adjuvant ; Female ; Hospitalization ; Humans ; Male ; Neoplasm Staging
Czasopismo naukowe
Tytuł :
Effect of the duration of the capecitabine regimen following colon cancer surgery in an elderly population: a retrospective cohort study.
Autorzy :
Chen W; Department of Clinical Medicine, Guizhou Medical University, Guiyang, China.; Department of Abdominal Oncology, Guizhou Province Cancer Hospital, Guiyang, China.
Dong H; Department of Abdominal Oncology, Guizhou Province Cancer Hospital, Guiyang, China.; Department of Oncology, Affiliated Hospital of Guizhou Medical University, No. 1 Beijing West Road, Guiyang, Guizhou, 550001, China.
Wang G; Department of Abdominal Oncology, Guizhou Province Cancer Hospital, Guiyang, China.; Department of Oncology, Affiliated Hospital of Guizhou Medical University, No. 1 Beijing West Road, Guiyang, Guizhou, 550001, China.
Chen J; Department of Clinical Medicine, Guizhou Medical University, Guiyang, China.; Department of Abdominal Oncology, Guizhou Province Cancer Hospital, Guiyang, China.
Wang W; Department of Abdominal Oncology, Guizhou Province Cancer Hospital, Guiyang, China. .; Department of Oncology, Affiliated Hospital of Guizhou Medical University, No. 1 Beijing West Road, Guiyang, Guizhou, 550001, China. .
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Źródło :
World journal of surgical oncology [World J Surg Oncol] 2021 Aug 11; Vol. 19 (1), pp. 238. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji :
Journal Article
MeSH Terms :
Colonic Neoplasms*/drug therapy
Colonic Neoplasms*/pathology
Colonic Neoplasms*/surgery
Fluorouracil*/therapeutic use
Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Capecitabine ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Humans ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Prognosis ; Retrospective Studies
Czasopismo naukowe
Tytuł :
[New recommendation on pharmacogenetic screening prior to 5-fluorouracil based cancer treatment - Swedish experience indicates less adverse effects and healthcare cost savings].
Autorzy :
Schultz A; läkarstudent termin 10, Uppsala universitet.
Kohnke H; biomedicinsk analytiker, klinisk kemi och farmakologi, Akademiska sjukhuset.
Wadelius M; professor, överläkare, institutionen för medi-cinska vetenskaper, Uppsala universitet; klinisk kemi och farmakologi, Akademiska sjukhuset.
Nygren P; professor, överläkare, institutionen för immunologi, genetik och patologi, Uppsala universitet; sektionen för onkologi, Akademiska sjukhuset; samtliga Uppsala.
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Transliterated Title :
Fördelaktigt med genetisk analys före behandling med 5-fluorouracil.
Źródło :
Lakartidningen [Lakartidningen] 2021 Aug 10; Vol. 118. Date of Electronic Publication: 2021 Aug 10.
Typ publikacji :
Journal Article
MeSH Terms :
Fluorouracil*/adverse effects
Neoplasms*/drug therapy
Neoplasms*/genetics
Antimetabolites, Antineoplastic/adverse effects ; Cost Savings ; Delivery of Health Care ; Dihydrouracil Dehydrogenase (NADP)/genetics ; Early Detection of Cancer ; Health Care Costs ; Humans ; Pharmacogenomic Testing ; Sweden
Czasopismo naukowe
Tytuł :
Relation between body composition and severe diarrhea in patients treated with preoperative chemoradiation with capecitabine for rectal cancer: a single-centre cohort study.
Autorzy :
van Rees JM; Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. .
Hartman W; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Nuyttens JJME; Department of Radiation Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Oomen-de Hoop E; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
van Vugt JLA; Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Rothbarth J; Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Verhoef C; Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
van Meerten E; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
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Źródło :
BMC gastroenterology [BMC Gastroenterol] 2021 Aug 04; Vol. 21 (1), pp. 313. Date of Electronic Publication: 2021 Aug 04.
Typ publikacji :
Journal Article
MeSH Terms :
Fluorouracil*/adverse effects
Rectal Neoplasms*/pathology
Rectal Neoplasms*/therapy
Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Body Composition ; Capecitabine/adverse effects ; Cohort Studies ; Deoxycytidine/adverse effects ; Diarrhea/chemically induced ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Age as a modifier of the effects of chemoradiotherapy with infusional 5-fluorouracil after D2 dissection in gastric cancer.
Autorzy :
Wu HC; Division of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan.
Lin WL; Division of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.
Lin CL; Division of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.
Lin CY; Division of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.; Department of Environmental and Occupational Health, National Cheng Kung University, Tainan, Taiwan.; Department of Senior Welfare and Services, Southern Taiwan University of Science and Technology, Tainan, Taiwan.
Chen SW; Division of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.
Chen YX; Division of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.
Chen CH; Division of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.
Lee SW; Department of Radiation Oncology, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.
Chen SH; National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.; Department of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Tsao CJ; Division of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.
Huang WT; Division of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.
Guo HR; Department of Environmental and Occupational Health, National Cheng Kung University, Tainan, Taiwan.; Department of Occupational and Environmental Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
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Źródło :
Aging [Aging (Albany NY)] 2021 Jul 05; Vol. 13 (13), pp. 17337-17348. Date of Electronic Publication: 2021 Jul 05.
Typ publikacji :
Journal Article
MeSH Terms :
Aging*
Antimetabolites, Antineoplastic/*administration & dosage
Antimetabolites, Antineoplastic/*therapeutic use
Chemoradiotherapy, Adjuvant/*methods
Fluorouracil/*administration & dosage
Fluorouracil/*therapeutic use
Stomach Neoplasms/*therapy
Adult ; Aged ; Aged, 80 and over ; Antimetabolites, Antineoplastic/adverse effects ; Chemoradiotherapy, Adjuvant/adverse effects ; Disease-Free Survival ; Female ; Fluorouracil/adverse effects ; Humans ; Infusions, Intravenous ; Lymph Node Excision/methods ; Male ; Middle Aged ; Prognosis ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/surgery ; Survival Analysis ; Taiwan ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Retrospective study evaluating the safety of administering pegfilgrastim on the final day of 5-fluorouracil continuous intravenous infusion.
Autorzy :
Draper AS; Emory Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Lafollette J; Georgia Cancer Center for Excellence at Grady Healthcare, Atlanta, GA, USA.
Kim C; Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Wu CS; Emory Winship Cancer Institute, Emory University, Atlanta, GA, USA.
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Źródło :
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners [J Oncol Pharm Pract] 2021 Jul; Vol. 27 (5), pp. 1159-1164. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
Filgrastim/*adverse effects
Fluorouracil/*administration & dosage
Gastrointestinal Neoplasms/*drug therapy
Neutropenia/*prevention & control
Polyethylene Glycols/*adverse effects
Adult ; Aged ; Aged, 80 and over ; Female ; Fluorouracil/adverse effects ; Humans ; Infusions, Intravenous ; Male ; Middle Aged ; Neutropenia/etiology ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Use of Half-Generation PAMAM Dendrimers (G0.5-G3.5) with Carboxylate End-Groups to Improve the DACHPtCl 2 and 5-FU Efficacy as Anticancer Drugs.
Autorzy :
Camacho C; CQM-Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal.
Tomás H; CQM-Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal.
Rodrigues J; CQM-Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal.; School of Materials Science and Engineering, Center for Nano Energy Materials, Northwestern Polytechnical University, Xi'an 710072, China.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 May 14; Vol. 26 (10). Date of Electronic Publication: 2021 May 14.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Dendrimers/*chemistry
Fluorouracil/*pharmacology
Organoplatinum Compounds/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carbon-13 Magnetic Resonance Spectroscopy ; Cell Line, Tumor ; DNA/metabolism ; Dendrimers/chemical synthesis ; Drug Liberation ; Fluorouracil/chemical synthesis ; Fluorouracil/chemistry ; Humans ; Inhibitory Concentration 50 ; Organoplatinum Compounds/chemical synthesis ; Organoplatinum Compounds/chemistry ; Proton Magnetic Resonance Spectroscopy ; Spectrophotometry, Ultraviolet ; Static Electricity ; Thermodynamics
Czasopismo naukowe
Tytuł :
Physicochemical characterization, drug release, and biocompatibility evaluation of carboxymethyl cellulose-based hydrogels reinforced with sepiolite nanoclay.
Autorzy :
Palem RR; Department of Medical Biotechnology, Biomedical Campus 32, Gyeonggi 10326, Republic of Korea.
Rao KM; School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Republic of Korea.
Shimoga G; Advanced Technology Research Center, Future Convergence Engineering, Korea University of Technology and Education, Cheonan-si, Chungcheongnam-do 330-708, Republic of Korea.
Saratale RG; Research Institute of Biotechnology and Medical Converged Science, Dongguk University-Seoul, Ilsandong-gu, Goyang-si, Gyeonggi-do, Seoul 10326, Republic of Korea.
Shinde SK; Department of Biological and Environmental Science, Dongguk University-Seoul, Ilsandong-gu, Goyang-si, Gyonggido, Seoul 10326, Republic of Korea.
Ghodake GS; Department of Biological and Environmental Science, Dongguk University-Seoul, Ilsandong-gu, Goyang-si, Gyonggido, Seoul 10326, Republic of Korea.
Lee SH; Department of Medical Biotechnology, Biomedical Campus 32, Gyeonggi 10326, Republic of Korea. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 May 01; Vol. 178, pp. 464-476. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article
MeSH Terms :
Fluorouracil*/chemistry
Fluorouracil*/pharmacokinetics
Carboxymethylcellulose Sodium/*chemistry
Drug Carriers/*chemistry
Hydrogels/*chemistry
Magnesium Silicates/*chemistry
Nanocomposites/*chemistry
Czasopismo naukowe
Tytuł :
ZIF-8 nano confined protein-titanocene complex core-shell MOFs for efficient therapy of Neuroblastoma: Optimization, molecular dynamics and toxicity studies.
Autorzy :
Kulkarni S; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka State, India.
Pandey A; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka State, India.
Nikam AN; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka State, India.
Nannuri SH; Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, Manipal 576104, Karnataka State, India.
George SD; Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, Manipal 576104, Karnataka State, India.
Fayaz SMA; Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, Karnataka State, India.
Vincent AP; Department of Research and Development, Glanbia Nutritionals, Twin Falls, ID, USA.
Mutalik S; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka State, India. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 May 01; Vol. 178, pp. 444-463. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*/adverse effects
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Fluorouracil*/adverse effects
Fluorouracil*/chemistry
Fluorouracil*/pharmacology
Imidazoles*/adverse effects
Imidazoles*/chemistry
Imidazoles*/pharmacology
Metal-Organic Frameworks*/adverse effects
Metal-Organic Frameworks*/chemistry
Metal-Organic Frameworks*/pharmacology
Molecular Dynamics Simulation*
Nanoparticles*/adverse effects
Nanoparticles*/chemistry
Nanoparticles*/therapeutic use
Neuroblastoma*/drug therapy
Neuroblastoma*/metabolism
Organometallic Compounds*/adverse effects
Organometallic Compounds*/chemistry
Organometallic Compounds*/pharmacology
Animals ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice.
Autorzy :
Sedlmayer F; Department of Biosystems Science and Engineering, ETH Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland.
Woischnig AK; Laboratory of Infection Biology, Department of Biomedicine, University and University Hospital Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland.
Unterreiner V; Novartis Institutes for BioMedical Research (NIBR), Chemical Biology and Therapeutics (CBT), CH-4033, Basel, Switzerland.
Fuchs F; Novartis Institutes for BioMedical Research (NIBR), Chemical Biology and Therapeutics (CBT), CH-4033, Basel, Switzerland.
Baeschlin D; Novartis Institutes for BioMedical Research (NIBR), Chemical Biology and Therapeutics (CBT), CH-4033, Basel, Switzerland.
Khanna N; Laboratory of Infection Biology, Department of Biomedicine, University and University Hospital Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland.; Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
Fussenegger M; Department of Biosystems Science and Engineering, ETH Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland.; Faculty of Science, University of Basel, Mattenstrasse 26, CH-4058 Basel, Switzerland.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jul 21; Vol. 49 (13), pp. e73.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biofilms/*drug effects
Enzyme Inhibitors/*pharmacology
Fluorouracil/*pharmacology
High-Throughput Screening Assays/*methods
Methicillin-Resistant Staphylococcus aureus/*drug effects
Quorum Sensing/*drug effects
Animals ; Bacterial Proteins/antagonists & inhibitors ; Carbon-Sulfur Lyases/antagonists & inhibitors ; Enzyme Inhibitors/therapeutic use ; Female ; Fluorouracil/therapeutic use ; HEK293 Cells ; Homoserine/analogs & derivatives ; Homoserine/biosynthesis ; Humans ; Lactones ; Methicillin-Resistant Staphylococcus aureus/metabolism ; Mice, Inbred C57BL ; N-Glycosyl Hydrolases/antagonists & inhibitors ; Small Molecule Libraries ; Staphylococcal Infections/prevention & control
Czasopismo naukowe
Tytuł :
Enhanced Vasculogenic Capacity Induced by 5-Fluorouracil Chemoresistance in a Gastric Cancer Cell Line.
Autorzy :
Peri S; Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, 3-50134 Firenze, Italy.
Biagioni A; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale G.B. Morgagni, 50-50134 Firenze, Italy.
Versienti G; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale G.B. Morgagni, 50-50134 Firenze, Italy.
Andreucci E; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale G.B. Morgagni, 50-50134 Firenze, Italy.
Staderini F; Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, 3-50134 Firenze, Italy.
Barbato G; Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, 3-50134 Firenze, Italy.
Giovannelli L; Department of Neuroscience, Psychology, Drug Research and Children's Health, University of Florence, Viale Pieraccini, 6-50139 Firenze, Italy.
Coratti F; Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, 3-50134 Firenze, Italy.
Schiavone N; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale G.B. Morgagni, 50-50134 Firenze, Italy.
Cianchi F; Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla, 3-50134 Firenze, Italy.
Papucci L; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale G.B. Morgagni, 50-50134 Firenze, Italy.
Magnelli L; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale G.B. Morgagni, 50-50134 Firenze, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 19; Vol. 22 (14). Date of Electronic Publication: 2021 Jul 19.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*/drug effects
Drug Resistance, Neoplasm*/genetics
Fluorouracil/*pharmacology
Neovascularization, Pathologic/*chemically induced
Stomach Neoplasms/*blood supply
Stomach Neoplasms/*drug therapy
Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacokinetics ; Cell Line, Tumor ; Cisplatin/pharmacology ; Endothelial Cells/drug effects ; Endothelial Cells/pathology ; Fluorouracil/metabolism ; Humans ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/pathology ; Paclitaxel/pharmacology ; Stomach Neoplasms/pathology ; Thalidomide/pharmacology ; Thymidine Phosphorylase/genetics ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Introducing longitudinal cumulative dose to describe chemotherapy patterns over time: Case study of a colon cancer trial.
Autorzy :
Webster-Clark M; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Keil AP; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Sanoff HK; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Stürmer T; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Westreich D; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Lund JL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
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Źródło :
International journal of cancer [Int J Cancer] 2021 Jul 15; Vol. 149 (2), pp. 394-402. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Colonic Neoplasms/*drug therapy
Fluorouracil/*administration & dosage
Leucovorin/*administration & dosage
Medication Adherence/*statistics & numerical data
Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Colonic Neoplasms/pathology ; Dose-Response Relationship, Drug ; Female ; Fluorouracil/therapeutic use ; Humans ; Leucovorin/therapeutic use ; Male ; Middle Aged ; Neoplasm Staging ; Organoplatinum Compounds/administration & dosage ; Organoplatinum Compounds/therapeutic use ; Treatment Outcome ; Young Adult
SCR Protocol :
Folfox protocol
Czasopismo naukowe
Tytuł :
New In Vitro-In Silico Approach for the Prediction of In Vivo Performance of Drug Combinations.
Autorzy :
Correia C; OncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Dr. Plácido da Costa, 4200-450 Porto, Portugal.; Faculty of Sciences, University of Porto, Rua do Campo Alegre, s/n, 4169-007 Porto, Portugal.
Ferreira A; OncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Dr. Plácido da Costa, 4200-450 Porto, Portugal.; LAQV/REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
Santos J; OncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Dr. Plácido da Costa, 4200-450 Porto, Portugal.
Lapa R; LAQV/REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
Yliperttula M; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland.
Urtti A; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland.
Vale N; OncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Dr. Plácido da Costa, 4200-450 Porto, Portugal.; MEDCIDS-Department of Community Medicine, Health Information and Decision, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jul 13; Vol. 26 (14). Date of Electronic Publication: 2021 Jul 13.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Deoxycytidine/*analogs & derivatives
Fluorouracil/*pharmacology
Antineoplastic Agents/pharmacokinetics ; Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Computer Simulation ; Deoxycytidine/pharmacokinetics ; Deoxycytidine/pharmacology ; Drug Combinations ; Fluorouracil/pharmacokinetics ; Humans ; Models, Biological ; Neoplasms/drug therapy
Czasopismo naukowe
Tytuł :
Tumor budding as a predictive marker for 5-fluorouracil response in adjuvant-treated stage III colorectal cancer.
Autorzy :
Akabane S; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Shimizu W; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. .
Takakura Y; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Kochi M; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Taguchi K; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Nakashima I; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Sato K; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Hattori M; Center for Medical Education, School of Medicine, Hiroshima University, Hiroshima, Japan.
Egi H; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Sentani K; Department of Molecular Pathology, Graduate School of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan.
Yasui W; Department of Molecular Pathology, Graduate School of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan.
Ohdan H; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
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Źródło :
International journal of clinical oncology [Int J Clin Oncol] 2021 Jul; Vol. 26 (7), pp. 1285-1292. Date of Electronic Publication: 2021 Apr 21.
Typ publikacji :
Journal Article
MeSH Terms :
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/pathology
Fluorouracil*/therapeutic use
Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Humans ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Prognosis ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Leukoencephalopathy with transient splenial lesions related to 5-fluorouracil or capecitabine.
Autorzy :
Perrain V; AP-HP Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Service de Neurologie 2-Mazarin, Sorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.
Bihan K; Regional Pharmacovigilance Center, Department of Pharmacology, Pitié-Salpêtrière Hospital, Paris, France.; OncoNeuroTox Group, Center for Patients with Neurological Complications of Oncologic Treatments, Hôpitaux Universitaires Pitié-Salpêtrière-Charles Foix et Hôpital Percy, Paris, France.
Bompaire F; OncoNeuroTox Group, Center for Patients with Neurological Complications of Oncologic Treatments, Hôpitaux Universitaires Pitié-Salpêtrière-Charles Foix et Hôpital Percy, Paris, France.; Department of Neurology, Service de Santé des Armées, Hôpital d'Instruction des Armées Percy, Clamart, France.
Houillier C; AP-HP Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Service de Neurologie 2-Mazarin, Sorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.
Jomier F; Service de Neurologie, Hôpital Saint Joseph, Paris, France.
Leclercq D; Service de Neuroradiologie, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Combret S; Department of Pharmacology, Regional Pharmacovigilance Center, Dijon, France.
Mahé J; Department of Pharmacology, Regional Pharmacovigilance Center, Nantes, France.
Ricard D; OncoNeuroTox Group, Center for Patients with Neurological Complications of Oncologic Treatments, Hôpitaux Universitaires Pitié-Salpêtrière-Charles Foix et Hôpital Percy, Paris, France.; Department of Neurology, Service de Santé des Armées, Hôpital d'Instruction des Armées Percy, Clamart, France.
Berzero G; AP-HP Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Service de Neurologie 2-Mazarin, Sorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Psimaras D; AP-HP Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Service de Neurologie 2-Mazarin, Sorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.; OncoNeuroTox Group, Center for Patients with Neurological Complications of Oncologic Treatments, Hôpitaux Universitaires Pitié-Salpêtrière-Charles Foix et Hôpital Percy, Paris, France.
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Źródło :
European journal of neurology [Eur J Neurol] 2021 Jul; Vol. 28 (7), pp. 2396-2402. Date of Electronic Publication: 2021 Apr 19.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Fluorouracil*/adverse effects
Leukoencephalopathies*/chemically induced
Leukoencephalopathies*/diagnostic imaging
Adult ; Antimetabolites, Antineoplastic/adverse effects ; Capecitabine/adverse effects ; Humans ; Retrospective Studies
Czasopismo naukowe

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