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Tytuł :
Ganoderma lucidum triterpenoids and polysaccharides attenuate atherosclerotic plaque in high-fat diet rabbits.
Autorzy :
Li Y; Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Medical Laboratory Animal Science, CAMS & PUMC, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, 100021, China.
Tang J; Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Medical Laboratory Animal Science, CAMS & PUMC, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, 100021, China.
Gao H; Department of Pathology, Qinghai Provincial People's Hospital, Qinghai, 810007, China.
Xu Y; Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Medical Laboratory Animal Science, CAMS & PUMC, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, 100021, China.
Han Y; Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Medical Laboratory Animal Science, CAMS & PUMC, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, 100021, China.
Shang H; Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Medical Laboratory Animal Science, CAMS & PUMC, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, 100021, China.
Lu Y; Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Medical Laboratory Animal Science, CAMS & PUMC, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, 100021, China.
Qin C; Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Medical Laboratory Animal Science, CAMS & PUMC, Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing, 100021, China. Electronic address: .
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Źródło :
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2021 Jun 07; Vol. 31 (6), pp. 1929-1938. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Plaque, Atherosclerotic*
Anti-Inflammatory Agents/*pharmacology
Antioxidants/*pharmacology
Aorta/*drug effects
Aortic Diseases/*prevention & control
Atherosclerosis/*prevention & control
Foam Cells/*drug effects
Polysaccharides/*pharmacology
Triterpenes/*pharmacology
Animals ; Anti-Inflammatory Agents/isolation & purification ; Antioxidants/isolation & purification ; Aorta/metabolism ; Aorta/pathology ; Aortic Diseases/metabolism ; Aortic Diseases/pathology ; Apoptosis/drug effects ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Cell Proliferation/drug effects ; Cytokines/metabolism ; Diet, High-Fat ; Disease Models, Animal ; Female ; Foam Cells/metabolism ; Foam Cells/pathology ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells/pathology ; Humans ; Inflammation Mediators/metabolism ; Male ; Oxidative Stress/drug effects ; Polysaccharides/isolation & purification ; Rabbits ; Reactive Oxygen Species/metabolism ; Reishi/chemistry ; THP-1 Cells ; Triterpenes/isolation & purification
Czasopismo naukowe
Tytuł :
Effect of oxytocin on lipid accumulation under inflammatory conditions in human macrophages.
Autorzy :
Karten A; NYU Langone Hospital - Long Island Biomedical Research Institute and NYU Long Island School of Medicine, Mineola, New York, United States of America.
Vernice NA; NYU Langone Hospital - Long Island Biomedical Research Institute and NYU Long Island School of Medicine, Mineola, New York, United States of America.
Renna HA; NYU Langone Hospital - Long Island Biomedical Research Institute and NYU Long Island School of Medicine, Mineola, New York, United States of America.
Carsons SE; NYU Langone Hospital - Long Island Biomedical Research Institute and NYU Long Island School of Medicine, Mineola, New York, United States of America.
DeLeon J; NYU Langone Hospital - Long Island Biomedical Research Institute and NYU Long Island School of Medicine, Mineola, New York, United States of America.
Pinkhasov A; NYU Langone Hospital - Long Island Biomedical Research Institute and NYU Long Island School of Medicine, Mineola, New York, United States of America.
Gomolin IH; NYU Langone Hospital - Long Island Biomedical Research Institute and NYU Long Island School of Medicine, Mineola, New York, United States of America.
Glass DS; NYU Langone Hospital - Long Island Biomedical Research Institute and NYU Long Island School of Medicine, Mineola, New York, United States of America.
Reiss AB; NYU Langone Hospital - Long Island Biomedical Research Institute and NYU Long Island School of Medicine, Mineola, New York, United States of America.
Kasselman LJ; NYU Langone Hospital - Long Island Biomedical Research Institute and NYU Long Island School of Medicine, Mineola, New York, United States of America. Electronic address: .
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Źródło :
Experimental and molecular pathology [Exp Mol Pathol] 2021 Feb; Vol. 118, pp. 104604. Date of Electronic Publication: 2021 Jan 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Atherosclerosis/*drug therapy
Cholesterol/*metabolism
Foam Cells/*drug effects
Inflammation/*drug therapy
Macrophages/*drug effects
Oxytocin/*pharmacology
Plaque, Atherosclerotic/*drug therapy
ATP Binding Cassette Transporter, Subfamily G, Member 1/metabolism ; Atherosclerosis/chemically induced ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Cells, Cultured ; Foam Cells/metabolism ; Foam Cells/pathology ; Humans ; Inflammation/chemically induced ; Inflammation/metabolism ; Inflammation/pathology ; Lipopolysaccharides/toxicity ; Macrophages/metabolism ; Macrophages/pathology ; Oxytocics/pharmacology ; Plaque, Atherosclerotic/chemically induced ; Plaque, Atherosclerotic/metabolism ; Plaque, Atherosclerotic/pathology ; Receptors, Oxytocin/metabolism
Czasopismo naukowe
Tytuł :
Mitochondrial protein CMPK2 regulates IFN alpha-enhanced foam cell formation, potentially contributing to premature atherosclerosis in SLE.
Autorzy :
Lai JH; Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Lin-Kou, Tao-Yuan, Taiwan, Republic of China.; Graduate Institute of Clinical Research, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Hung LF; Institute of Cellular and System Medicine, National Health Research Institute, Zhunan, Taiwan, Republic of China.
Huang CY; Institute of Cellular and System Medicine, National Health Research Institute, Zhunan, Taiwan, Republic of China.
Wu DW; Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Lin-Kou, Tao-Yuan, Taiwan, Republic of China.
Wu CH; Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Lin-Kou, Tao-Yuan, Taiwan, Republic of China.
Ho LJ; Institute of Cellular and System Medicine, National Health Research Institute, Zhunan, Taiwan, Republic of China. .
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Źródło :
Arthritis research & therapy [Arthritis Res Ther] 2021 Apr 19; Vol. 23 (1), pp. 120. Date of Electronic Publication: 2021 Apr 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Atherosclerosis*/complications
Foam Cells*
Interferon-alpha*
Lupus Erythematosus, Systemic*/complications
Nucleoside-Phosphate Kinase/*metabolism
Humans ; Lipoproteins, LDL ; Mitochondrial Proteins
Czasopismo naukowe
Tytuł :
Plasminogen-induced foam cell formation by macrophages occurs through a histone 2B (H2B)-PAR1 pathway and requires integrity of clathrin-coated pits.
Autorzy :
Izem L; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, Ohio, USA.
Bialkowska K; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, Ohio, USA.
Pluskota E; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, Ohio, USA.
Das M; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, Ohio, USA.
Das R; Roberts J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Nieman MT; Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA.
Plow EF; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute Cleveland Clinic, Cleveland, Ohio, USA.
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Źródło :
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2021 Apr; Vol. 19 (4), pp. 941-953. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Foam Cells*/metabolism
Plasminogen*/metabolism
Animals ; Clathrin/metabolism ; Fibrinolysin/metabolism ; Histones ; Macrophages/metabolism ; Mice ; Receptor, PAR-1
Czasopismo naukowe
Tytuł :
The vitamin E long-chain metabolite α-13'-COOH affects macrophage foam cell formation via modulation of the lipoprotein lipase system.
Autorzy :
Kluge S; Institute of Nutritional Sciences, Friedrich Schiller University, Jena, Germany.
Schubert M; Institute of Nutritional Sciences, Friedrich Schiller University, Jena, Germany.
Börmel L; Institute of Nutritional Sciences, Friedrich Schiller University, Jena, Germany.
Lorkowski S; Institute of Nutritional Sciences, Friedrich Schiller University, Jena, Germany; Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Germany. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2021 Apr; Vol. 1866 (4), pp. 158875. Date of Electronic Publication: 2021 Jan 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzopyrans/*metabolism
Fatty Acids/*metabolism
Foam Cells/*metabolism
Lipoprotein Lipase/*metabolism
Macrophages/*metabolism
Vitamin E/*metabolism
Cell Line ; Down-Regulation ; Foam Cells/cytology ; Humans ; Lipoprotein Lipase/genetics ; Macrophages/cytology ; RNA, Messenger/genetics
Czasopismo naukowe
Tytuł :
An advanced method for quantitative measurements of cholesterol crystallization.
Autorzy :
Halkias C; School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia.
Orth A; ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), School of Science, RMIT University, Melbourne, Victoria 3001, Australia; National Research Council of Canada, Ottawa, Canada.
Feltis BN; School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia.
Macrides TA; School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia.
Gibson BC; ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), School of Science, RMIT University, Melbourne, Victoria 3001, Australia.
Wright PFA; School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2021 Mar; Vol. 1866 (3), pp. 158872. Date of Electronic Publication: 2020 Dec 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cholesterol/*metabolism
Foam Cells/*cytology
Monocytes/*cytology
Plaque, Atherosclerotic/*metabolism
Cholesterol/chemistry ; Crystallization ; Foam Cells/metabolism ; Foam Cells/ultrastructure ; Humans ; Microscopy, Polarization ; Monocytes/metabolism ; Monocytes/ultrastructure ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Chondroitin Sulfate N -acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain.
Autorzy :
Adhikara IM; Laboratory of Clinical Pharmaceutical Science (I.M.A., K.Y., D.S.M., Y.S., K.I., G.R.T.R., N.E.), Kobe Pharmaceutical University, Japan.; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan (I.M.A., D.S.M., Y.S., G.R.T.R., K.-i.H., N.E.).
Yagi K; Laboratory of Clinical Pharmaceutical Science (I.M.A., K.Y., D.S.M., Y.S., K.I., G.R.T.R., N.E.), Kobe Pharmaceutical University, Japan.
Mayasari DS; Laboratory of Clinical Pharmaceutical Science (I.M.A., K.Y., D.S.M., Y.S., K.I., G.R.T.R., N.E.), Kobe Pharmaceutical University, Japan.; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan (I.M.A., D.S.M., Y.S., G.R.T.R., K.-i.H., N.E.).
Suzuki Y; Laboratory of Clinical Pharmaceutical Science (I.M.A., K.Y., D.S.M., Y.S., K.I., G.R.T.R., N.E.), Kobe Pharmaceutical University, Japan.; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan (I.M.A., D.S.M., Y.S., G.R.T.R., K.-i.H., N.E.).
Ikeda K; Laboratory of Clinical Pharmaceutical Science (I.M.A., K.Y., D.S.M., Y.S., K.I., G.R.T.R., N.E.), Kobe Pharmaceutical University, Japan.
Ryanto GRT; Laboratory of Clinical Pharmaceutical Science (I.M.A., K.Y., D.S.M., Y.S., K.I., G.R.T.R., N.E.), Kobe Pharmaceutical University, Japan.; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan (I.M.A., D.S.M., Y.S., G.R.T.R., K.-i.H., N.E.).
Sasaki N; Laboratory of Medical Pharmaceutics (N.S., Y.R.), Kobe Pharmaceutical University, Japan.
Rikitake Y; Laboratory of Medical Pharmaceutics (N.S., Y.R.), Kobe Pharmaceutical University, Japan.
Nadanaka S; Laboratory of Biochemistry (S.N., H.K.), Kobe Pharmaceutical University, Japan.
Kitagawa H; Laboratory of Biochemistry (S.N., H.K.), Kobe Pharmaceutical University, Japan.
Miyata O; Laboratory of Medicinal Chemistry (O.M.), Kobe Pharmaceutical University, Japan.
Igarashi M; Department of Neurochemistry and Molecular Cell Biology, School of Medicine and Graduate School of Medical/Dental Sciences, Niigata University, Japan (M.I.).
Hirata KI; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan (I.M.A., D.S.M., Y.S., G.R.T.R., K.-i.H., N.E.).
Emoto N; Laboratory of Clinical Pharmaceutical Science (I.M.A., K.Y., D.S.M., Y.S., K.I., G.R.T.R., N.E.), Kobe Pharmaceutical University, Japan.; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan (I.M.A., D.S.M., Y.S., G.R.T.R., K.-i.H., N.E.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Mar; Vol. 41 (3), pp. 1076-1091. Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Atherosclerosis/*metabolism
Foam Cells/*metabolism
Glycosaminoglycans/*metabolism
N-Acetylgalactosaminyltransferases/*metabolism
Animals ; Atherosclerosis/etiology ; Atherosclerosis/pathology ; Disease Models, Animal ; Female ; Foam Cells/pathology ; Glycosaminoglycans/chemistry ; Lipoproteins, LDL/metabolism ; Macrophages, Peritoneal/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; N-Acetylgalactosaminyltransferases/deficiency ; N-Acetylgalactosaminyltransferases/genetics ; Plaque, Atherosclerotic/etiology ; Plaque, Atherosclerotic/metabolism ; Plaque, Atherosclerotic/pathology ; RAW 264.7 Cells ; Up-Regulation
Czasopismo naukowe
Tytuł :
Pro-inflammatory molecules induce cholesterol accumulation in macrophages: Role of inflammatory response in foam cell formation.
Autorzy :
Orekhov AN; Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, Moscow, 125315, Russian Federation; Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Institute of Human Morphology, 3 Tsyurupa Street, Moscow, 117418, Russian Federation. Electronic address: .
Markin AM; Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Institute of Human Morphology, 3 Tsyurupa Street, Moscow, 117418, Russian Federation.
Sukhorukov VN; Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Institute of Human Morphology, 3 Tsyurupa Street, Moscow, 117418, Russian Federation.
Khotina VA; Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Institute of Human Morphology, 3 Tsyurupa Street, Moscow, 117418, Russian Federation.
Ivanova E; Institute for Atherosclerosis Research, Skolkovo Innovative Center, Osennyaya Street 4-1-7, Moscow, 121609, Russian Federation. Electronic address: .
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Źródło :
Atherosclerosis [Atherosclerosis] 2021 Mar; Vol. 320, pp. 129-130. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Letter; Comment
MeSH Terms :
Atherosclerosis*
Foam Cells*
Cholesterol ; Humans ; Macrophages
Opinia redakcyjna
Tytuł :
Porphyromonas gingivalis facilitated the foam cell formation via lysosomal integral membrane protein 2 (LIMP2).
Autorzy :
Yang Y; Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Periodontics, School of Stomatology, Tongji University, Shanghai, China.
He X; Dental Diseases Prevention & Treatment Center of Jiading District, Shanghai, China.
Xia S; Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Periodontics, School of Stomatology, Tongji University, Shanghai, China.
Liu F; Shanghai Key Laboratory of Sleep Disordered Breathing, Department of Otolaryngology, Therapy Center for Obstructive Sleep Apnea, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Luo L; Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Periodontics, School of Stomatology, Tongji University, Shanghai, China.
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Źródło :
Journal of periodontal research [J Periodontal Res] 2021 Apr; Vol. 56 (2), pp. 265-274. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article
MeSH Terms :
Foam Cells*
Porphyromonas gingivalis*
Lipoproteins, LDL ; Lysosome-Associated Membrane Glycoproteins ; Macrophages
Czasopismo naukowe
Tytuł :
[Amentoflavone inhibits M1 polarization of THP-1-derived foam cells by activating PPAR- α / γ ].
Autorzy :
Qiu F; Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University, Foshan 528244, China.
Zhang L; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Zheng J; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Cao L; Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University, Foshan 528244, China.
Zhang Z; Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University, Foshan 528244, China.
Deng Y; Department of Emergency, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
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Źródło :
Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2021 Mar 25; Vol. 41 (3), pp. 344-351.
Typ publikacji :
Journal Article
MeSH Terms :
Foam Cells*
PPAR gamma*
Biflavonoids ; Humans ; Lipopolysaccharides ; Molecular Docking Simulation ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Aggregated LDL turn human macrophages into foam cells and induce mitochondrial dysfunction without triggering oxidative or endoplasmic reticulum stress.
Autorzy :
Sanda GM; Lipidomics Department, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, Bucharest, Romania.
Stancu CS; Lipidomics Department, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, Bucharest, Romania.
Deleanu M; Lipidomics Department, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, Bucharest, Romania.; Faculty of Biotechnology, University of Agronomical Sciences and Veterinary Medicine, Bucharest, Romania.
Toma L; Lipidomics Department, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, Bucharest, Romania.
Niculescu LS; Lipidomics Department, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, Bucharest, Romania.
Sima AV; Lipidomics Department, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, Bucharest, Romania.
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Źródło :
PloS one [PLoS One] 2021 Jan 25; Vol. 16 (1), pp. e0245797. Date of Electronic Publication: 2021 Jan 25 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Aggregates*
Endoplasmic Reticulum Stress/*drug effects
Foam Cells/*drug effects
Lipoproteins, LDL/*chemistry
Lipoproteins, LDL/*pharmacology
Mitochondria/*drug effects
Oxidative Stress/*drug effects
Apoptosis/drug effects ; Cell Line, Tumor ; Cholesterol/metabolism ; Foam Cells/cytology ; Foam Cells/metabolism ; Humans ; Intracellular Space/drug effects ; Intracellular Space/metabolism ; Mitochondria/metabolism
Czasopismo naukowe
Tytuł :
Microbiota-Mediated Immune Regulation in Atherosclerosis.
Autorzy :
Eshghjoo S; Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University Health Science Center, Bryan, TX 77807, USA.
Jayaraman A; Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77840, USA.
Sun Y; Department of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Alaniz RC; Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University Health Science Center, Bryan, TX 77807, USA.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Jan 01; Vol. 26 (1). Date of Electronic Publication: 2021 Jan 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Atherosclerosis*/immunology
Atherosclerosis*/metabolism
Atherosclerosis*/microbiology
Atherosclerosis*/pathology
Foam Cells*/immunology
Foam Cells*/metabolism
Foam Cells*/pathology
Indican*/immunology
Indican*/metabolism
Methylamines*/immunology
Methylamines*/metabolism
Gastrointestinal Microbiome/*immunology
Animals ; Basic Helix-Loop-Helix Transcription Factors/immunology ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/microbiology ; Inflammation/pathology ; Receptors, Aryl Hydrocarbon/immunology ; Receptors, Aryl Hydrocarbon/metabolism
Czasopismo naukowe
Tytuł :
Gypenoside inhibits ox-LDL uptake and foam cell formation through enhancing Sirt1-FOXO1 mediated autophagy flux restoration.
Autorzy :
Hui B; Department of Cardiology, Qingdao Municipal Hospital of Qingdao University, Qingdao, 266071, China.
Hou X; School of Medicine, the University of Missouri, Columbia, MO 65201, USA.
Liu R; Department of Cardiovascular Diseases, Tongji Hospital of Tongji University, Shanghai 200065, China.
Liu XH; Cardiovascular Department of Internal Medicine, Central Hospital of Karamay, Karamay 834000, Xinjiang Uyghur Autonomous Region, China. Electronic address: .
Hu Z; Department of Cardiovascular Diseases, Tongji Hospital of Tongji University, Shanghai 200065, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118721. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*/drug effects
Foam Cells/*metabolism
Forkhead Box Protein O1/*metabolism
Lipoproteins, LDL/*metabolism
Sirtuin 1/*metabolism
Foam Cells/drug effects ; Forkhead Box Protein O1/genetics ; Gynostemma ; Humans ; Lysosomes/drug effects ; Lysosomes/metabolism ; Plant Extracts/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Sirtuin 1/genetics ; THP-1 Cells ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Epac1 (Exchange Protein Directly Activated by cAMP 1) Upregulates LOX-1 (Oxidized Low-Density Lipoprotein Receptor 1) to Promote Foam Cell Formation and Atherosclerosis Development.
Autorzy :
Robichaux WG 3rd; Department of Integrative Biology and Pharmacology (W.G.R., F.C.M., W.Y., H.W., X.C.), McGovern Medical School, The University of Texas Health Science Center, Houston.; Texas Therapeutics Institute (W.G.R., F.C.M., W.Y., H.W., X.C.), McGovern Medical School, The University of Texas Health Science Center, Houston.; Brown Foundation Institute of Molecular Medicine (W.G.R., F.C.M., W.Y., H.W., H.S., B.-B.T.), McGovern Medical School, The University of Texas Health Science Center, Houston.
Mei FC; Department of Integrative Biology and Pharmacology (W.G.R., F.C.M., W.Y., H.W., X.C.), McGovern Medical School, The University of Texas Health Science Center, Houston.; Texas Therapeutics Institute (W.G.R., F.C.M., W.Y., H.W., X.C.), McGovern Medical School, The University of Texas Health Science Center, Houston.; Brown Foundation Institute of Molecular Medicine (W.G.R., F.C.M., W.Y., H.W., H.S., B.-B.T.), McGovern Medical School, The University of Texas Health Science Center, Houston.
Yang W; Department of Integrative Biology and Pharmacology (W.G.R., F.C.M., W.Y., H.W., X.C.), McGovern Medical School, The University of Texas Health Science Center, Houston.; Texas Therapeutics Institute (W.G.R., F.C.M., W.Y., H.W., X.C.), McGovern Medical School, The University of Texas Health Science Center, Houston.; Brown Foundation Institute of Molecular Medicine (W.G.R., F.C.M., W.Y., H.W., H.S., B.-B.T.), McGovern Medical School, The University of Texas Health Science Center, Houston.
Wang H; Department of Integrative Biology and Pharmacology (W.G.R., F.C.M., W.Y., H.W., X.C.), McGovern Medical School, The University of Texas Health Science Center, Houston.; Texas Therapeutics Institute (W.G.R., F.C.M., W.Y., H.W., X.C.), McGovern Medical School, The University of Texas Health Science Center, Houston.; Brown Foundation Institute of Molecular Medicine (W.G.R., F.C.M., W.Y., H.W., H.S., B.-B.T.), McGovern Medical School, The University of Texas Health Science Center, Houston.
Sun H; Brown Foundation Institute of Molecular Medicine (W.G.R., F.C.M., W.Y., H.W., H.S., B.-B.T.), McGovern Medical School, The University of Texas Health Science Center, Houston.
Zhou Z; Division of Medical Genetics, Department of Internal Medicine (Z.Z., D.M.M.), McGovern Medical School, The University of Texas Health Science Center, Houston.
Milewicz DM; Division of Medical Genetics, Department of Internal Medicine (Z.Z., D.M.M.), McGovern Medical School, The University of Texas Health Science Center, Houston.
Teng BB; Brown Foundation Institute of Molecular Medicine (W.G.R., F.C.M., W.Y., H.W., H.S., B.-B.T.), McGovern Medical School, The University of Texas Health Science Center, Houston.
Cheng X; Department of Integrative Biology and Pharmacology (W.G.R., F.C.M., W.Y., H.W., X.C.), McGovern Medical School, The University of Texas Health Science Center, Houston.; Texas Therapeutics Institute (W.G.R., F.C.M., W.Y., H.W., X.C.), McGovern Medical School, The University of Texas Health Science Center, Houston.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Dec; Vol. 40 (12), pp. e322-e335. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Plaque, Atherosclerotic*
Aorta, Thoracic/*metabolism
Aortic Diseases/*metabolism
Atherosclerosis/*metabolism
Foam Cells/*metabolism
Guanine Nucleotide Exchange Factors/*metabolism
Scavenger Receptors, Class E/*metabolism
APOBEC-1 Deaminase/deficiency ; APOBEC-1 Deaminase/genetics ; Animals ; Aorta, Thoracic/pathology ; Aortic Diseases/genetics ; Aortic Diseases/pathology ; Atherosclerosis/genetics ; Atherosclerosis/pathology ; Cyclic AMP/metabolism ; Disease Models, Animal ; Disease Progression ; Female ; Foam Cells/pathology ; Guanine Nucleotide Exchange Factors/deficiency ; Guanine Nucleotide Exchange Factors/genetics ; Humans ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, LDL/deficiency ; Receptors, LDL/genetics ; Second Messenger Systems ; THP-1 Cells ; Vascular Remodeling
Czasopismo naukowe
Tytuł :
Acidic extracellular pH promotes accumulation of free cholesterol in human monocyte-derived macrophages via inhibition of ACAT1 activity.
Autorzy :
Lee-Rueckert M; Wihuri Research Institute, Helsinki, Finland.
Lappalainen J; Wihuri Research Institute, Helsinki, Finland.
Leinonen H; Wihuri Research Institute, Helsinki, Finland.
Plihtari R; Wihuri Research Institute, Helsinki, Finland.
Nordström T; University of Helsinki, Biomedicum, Medicum/Physiology, Helsinki, FIN-00014, Finland.
Åkerman K; University of Helsinki, Biomedicum, Medicum/Physiology, Helsinki, FIN-00014, Finland.
Öörni K; Wihuri Research Institute, Helsinki, Finland.
Kovanen PT; Wihuri Research Institute, Helsinki, Finland. Electronic address: .
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Źródło :
Atherosclerosis [Atherosclerosis] 2020 Nov; Vol. 312, pp. 1-7. Date of Electronic Publication: 2020 Sep 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cholesterol*
Foam Cells*
Acetyl-CoA C-Acetyltransferase ; Cholesterol Esters ; Humans ; Hydrogen-Ion Concentration ; Macrophages
Czasopismo naukowe
Tytuł :
MicroRNA-761 modulates foam cell formation and inflammation through autophagy in the progression of atherosclerosis.
Autorzy :
Wang C; Department of Laboratory Diagnostics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, NanGang, Harbin, 150001, Heilongjiang, People's Republic of China.
Yang W; Department of Laboratory Diagnostics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, NanGang, Harbin, 150001, Heilongjiang, People's Republic of China.
Liang X; Department of Laboratory Diagnostics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, NanGang, Harbin, 150001, Heilongjiang, People's Republic of China.
Song W; Department of Laboratory Diagnostics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, NanGang, Harbin, 150001, Heilongjiang, People's Republic of China.
Lin J; Department of Laboratory Diagnostics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, NanGang, Harbin, 150001, Heilongjiang, People's Republic of China.
Sun Y; Department of Laboratory Diagnostics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, NanGang, Harbin, 150001, Heilongjiang, People's Republic of China.
Guan X; Department of Laboratory Diagnostics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, NanGang, Harbin, 150001, Heilongjiang, People's Republic of China. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2020 Nov; Vol. 474 (1-2), pp. 135-146. Date of Electronic Publication: 2020 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*
Atherosclerosis/*pathology
Foam Cells/*pathology
Inflammation/*pathology
Macrophages/*pathology
MicroRNAs/*genetics
Atherosclerosis/metabolism ; Disease Progression ; Foam Cells/metabolism ; Humans ; Inflammation/metabolism ; Macrophages/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Myeloid Ezh2 Deficiency Limits Atherosclerosis Development.
Autorzy :
Neele AE; Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Chen HJ; Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Gijbels MJJ; Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Pathology and Department of Molecular Genetics, CARIM, Maastricht University, Maastricht, Netherlands.
van der Velden S; Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Hoeksema MA; Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, CA, United States.
Boshuizen MCS; Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Van den Bossche J; Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Molecular Cell Biology and Immunology, Amsterdam Cardiovascular Sciences, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Tool AT; Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Matlung HL; Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
van den Berg TK; Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Lutgens E; Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Institue for Cardivascular Prevention (IPEK), Ludwig Maximilias University (LMU), Munich, Germany.
de Winther MPJ; Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Jan 26; Vol. 11, pp. 594603. Date of Electronic Publication: 2021 Jan 26 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Atherosclerosis/*immunology
Enhancer of Zeste Homolog 2 Protein/*deficiency
Foam Cells/*immunology
Animals ; Atherosclerosis/genetics ; Atherosclerosis/pathology ; Enhancer of Zeste Homolog 2 Protein/immunology ; Foam Cells/pathology ; Interleukin-12/genetics ; Interleukin-12/immunology ; Interleukin-6/genetics ; Interleukin-6/immunology ; Mice ; Mice, Knockout ; Organ Specificity
Czasopismo naukowe
Tytuł :
Triacylglycerol synthesis directed by glycerol-3-phosphate acyltransferases -3 and -4 is required for lipid droplet formation and the modulation of the inflammatory response during macrophage to foam cell transition.
Autorzy :
Quiroga IY; Instituto de Investigaciones Bioquímicas de La Plata, Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, 1900, Argentina.
Pellon-Maison M; Instituto de Investigaciones Bioquímicas de La Plata, Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, 1900, Argentina.
Gonzalez MC; Instituto de Investigaciones Bioquímicas de La Plata, Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, 1900, Argentina.
Coleman RA; Department of Nutrition, University of North Carolina, Chapel Hill, NC, 27599, USA.
Gonzalez-Baro MR; Instituto de Investigaciones Bioquímicas de La Plata, Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, 1900, Argentina. Electronic address: .
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Źródło :
Atherosclerosis [Atherosclerosis] 2021 Jan; Vol. 316, pp. 1-7. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Foam Cells*
Lipid Droplets*
1-Acylglycerol-3-Phosphate O-Acyltransferase/genetics ; Animals ; Glycerol ; Glycerol-3-Phosphate O-Acyltransferase/genetics ; Lipoproteins, LDL ; Macrophages ; Mice ; Phosphates ; Triglycerides
Czasopismo naukowe
Tytuł :
Monocyte Recruitment, Specification, and Function in Atherosclerosis.
Autorzy :
Kim KW; Department of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Ivanov S; INSERM U1065, Centre Méditerranéen de Médecine Moléculaire C3M, Université Côte Azur, 06204 Nice, France.
Williams JW; Center for Immunology, Department of Integrative Biology & Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
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Źródło :
Cells [Cells] 2020 Dec 24; Vol. 10 (1). Date of Electronic Publication: 2020 Dec 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Atherosclerosis/*metabolism
Foam Cells/*metabolism
Monocytes/*metabolism
Plaque, Atherosclerotic/*metabolism
Animals ; Cell Differentiation ; Cell Movement ; Cytokines/metabolism ; Foam Cells/cytology ; Humans ; Mice ; Monocytes/pathology
Czasopismo naukowe

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