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Wyświetlanie 1-20 z 11209
Tytuł:
Activated PyK2 and Its Associated Molecules Transduce Cellular Signaling from the Cancerous Milieu for Cancer Metastasis.
Autorzy:
Lee D; Department of Health Sciences and Technology, Lee Gil Ya Cancer and Diabetes Institute, Gachon Advanced Institute for Health Sciences & Technology, Gachon University, 155 Getbeolro, Yeonsu-gu, Incheon 21999, Republic of Korea.
Hong JH; Department of Health Sciences and Technology, Lee Gil Ya Cancer and Diabetes Institute, Gachon Advanced Institute for Health Sciences & Technology, Gachon University, 155 Getbeolro, Yeonsu-gu, Incheon 21999, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 07; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 07.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Focal Adhesion Kinase 2*/metabolism
Neoplasms*
src-Family Kinases/metabolism ; Phosphorylation ; Focal Adhesion Kinase 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
FAK mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation by modulating mitochondrial transcription termination factor 1/cyclin D1.
Autorzy:
Lin C; Department of Respiratory and Critical Care Medicine, Yueyang People's Hospital of Hunan Normal University, Yueyang, China.
Yang H; Department of Respiratory and Critical Care Medicine, Yueyang People's Hospital of Hunan Normal University, Yueyang, China.
Luo Q; Department of Respiratory and Critical Care Medicine, Yueyang People's Hospital of Hunan Normal University, Yueyang, China.
Liu Q; Department of Respiratory and Critical Care Medicine, Yueyang People's Hospital of Hunan Normal University, Yueyang, China.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2024 Mar; Vol. 17 (3), pp. e13767.
Typ publikacji:
Journal Article
MeSH Terms:
Cyclin D1*/genetics
Cyclin D1*/metabolism
Pulmonary Artery*/metabolism
Basic-Leucine Zipper Transcription Factors*/metabolism
Focal Adhesion Kinase 1*/metabolism
Humans ; Cell Proliferation ; Cells, Cultured ; Hypoxia ; Myocytes, Smooth Muscle/metabolism ; RNA, Small Interfering
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeting of focal adhesion kinase enhances the immunogenic cell death of PEGylated liposome doxorubicin to optimize therapeutic responses of immune checkpoint blockade.
Autorzy:
Zhang, Baoyuan (AUTHOR)
Li, Ning (AUTHOR)
Gao, Jiaming (AUTHOR)
Zhao, Yuxi (AUTHOR)
Jiang, Jun (AUTHOR)
Xie, Shuang (AUTHOR)
Zhang, Cuiping (AUTHOR)
Zhang, Qingyu (AUTHOR)
Liu, Leo (AUTHOR)
Wang, Zaiqi (AUTHOR)
Ji, Dongmei (AUTHOR)
Wu, Lingying (AUTHOR)
Ren, Ruibao (AUTHOR)
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Źródło:
Journal of Experimental & Clinical Cancer Research (17569966). 2/19/2024, Vol. 43 Issue 1, p1-21. 21p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tubulointerstitial nephritis antigen-like 1 from cancer-associated fibroblasts contribute to the progression of diffuse-type gastric cancers through the interaction with integrin β1.
Autorzy:
Lee, Dagyeong (AUTHOR)
Ham, In-Hye (AUTHOR)
Oh, Hye Jeong (AUTHOR)
Lee, Dong Min (AUTHOR)
Yoon, Jung Hwan (AUTHOR)
Son, Sang-Yong (AUTHOR)
Kim, Tae-Min (AUTHOR)
Kim, Jae-Young (AUTHOR)
Han, Sang-Uk (AUTHOR)
Hur, Hoon (AUTHOR)
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Źródło:
Journal of Translational Medicine. 2/15/2024, Vol. 22 Issue 1, p1-18. 18p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Filamin C Deficiency Impairs Sarcomere Stability and Activates Focal Adhesion Kinase through PDGFRA Signaling in Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Autorzy:
Gao, Shanshan (AUTHOR)
He, Lingaonan (AUTHOR)
Lam, Chi Keung (AUTHOR)
Taylor, Matthew R. G. (AUTHOR)
Mestroni, Luisa (AUTHOR)
Lombardi, Raffaella (AUTHOR)
Chen, Suet Nee (AUTHOR)
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Źródło:
Cells (2073-4409). Feb2024, Vol. 13 Issue 3, p278. 16p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases.
Autorzy:
Dhawka L; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Palfini V; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Hambright E; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Blanco I; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Poon C; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Kahl A; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Resch U; Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Bhawal R; Institute of Biotechnology, Cornell University, Ithaca, NY, USA.
Benakis C; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.; Institute for Stroke and Dementia Research, Ludwig-Maximilians-University Munich, Munich, Germany.
Balachandran V; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Holder A; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Zhang S; Institute of Biotechnology, Cornell University, Ithaca, NY, USA.
Iadecola C; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Hochrainer K; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA. .
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Źródło:
Communications biology [Commun Biol] 2024 Mar 13; Vol. 7 (1), pp. 321. Date of Electronic Publication: 2024 Mar 13.
Typ publikacji:
Journal Article
MeSH Terms:
Stroke*
Ischemic Stroke*
Mice ; Animals ; Disks Large Homolog 4 Protein ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 ; Focal Adhesion Kinase 2 ; Post-Synaptic Density ; Phosphotransferases ; Ubiquitination ; Ischemia ; Ubiquitin
Czasopismo naukowe
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Tytuł:
PTK2-associated gene signature could predict the prognosis of IPF.
Autorzy:
Feng A; Center for Translational Science, and Department of Environmental Health, Florida International University, Port St. Lucie, FL, 36987, USA.
Caro YM; Department of Internal Medicine, University of Arizona, Phoenix, AZ, 85004, USA.
Gardner C; Department of Internal Medicine, University of Arizona, Phoenix, AZ, 85004, USA.
Grischo G; Department of Internal Medicine, University of Arizona, Phoenix, AZ, 85004, USA.
Liang Y; Center for Translational Science, and Department of Environmental Health, Florida International University, Port St. Lucie, FL, 36987, USA.
Wickremasinghe PD; Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, FL, 33199, USA.
Polmann M; Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, FL, 33199, USA.
Kala M; Department of Internal Medicine, University of Arizona, Phoenix, AZ, 85004, USA.
Marlowe T; Department of Internal Medicine, University of Arizona, Phoenix, AZ, 85004, USA.
Black SM; Center for Translational Science, and Department of Environmental Health, Florida International University, Port St. Lucie, FL, 36987, USA.; Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, FL, 33199, USA.
Knox KS; Department of Internal Medicine, University of Arizona, Phoenix, AZ, 85004, USA.
Wang T; Center for Translational Science, and Department of Environmental Health, Florida International University, Port St. Lucie, FL, 36987, USA. .; Department of Internal Medicine, University of Arizona, Phoenix, AZ, 85004, USA. .; Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, FL, 33199, USA. .; Center for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, FL, 34987, USA. .
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Źródło:
Respiratory research [Respir Res] 2023 Dec 06; Vol. 24 (1), pp. 304. Date of Electronic Publication: 2023 Dec 06.
Typ publikacji:
Journal Article
MeSH Terms:
Idiopathic Pulmonary Fibrosis*/diagnosis
Idiopathic Pulmonary Fibrosis*/genetics
Idiopathic Pulmonary Fibrosis*/metabolism
Humans ; Focal Adhesion Kinase 1/genetics ; Focal Adhesion Kinase 1/metabolism ; Lung/metabolism ; Prognosis ; Biomarkers/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mechanical Intercellular Communication via Matrix‐Borne Cell Force Transmission During Vascular Network Formation.
Autorzy:
Davidson, Christopher D. (AUTHOR)
Midekssa, Firaol S. (AUTHOR)
DePalma, Samuel J. (AUTHOR)
Kamen, Jordan L. (AUTHOR)
Wang, William Y. (AUTHOR)
Jayco, Danica Kristen P. (AUTHOR)
Wieger, Megan E. (AUTHOR)
Baker, Brendon M. (AUTHOR)
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Źródło:
Advanced Science. 1/19/2024, Vol. 11 Issue 3, p1-15. 15p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tumor removal limits prostate cancer cell dissemination in bone and osteoblasts induce cancer cell dormancy through focal adhesion kinase.
Autorzy:
Liu, Ruihua (AUTHOR)
Su, Shang (AUTHOR)
Xing, Jing (AUTHOR)
Liu, Ke (AUTHOR)
Zhao, Yawei (AUTHOR)
Stangis, Mary (AUTHOR)
Jacho, Diego P. (AUTHOR)
Yildirim-Ayan, Eda D. (AUTHOR)
Gatto-Weis, Cara M. (AUTHOR)
Chen, Bin (AUTHOR)
Li, Xiaohong (AUTHOR)
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Źródło:
Journal of Experimental & Clinical Cancer Research (17569966). 11/21/2023, Vol. 42 Issue 1, p1-18. 18p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
3D Chiral Self‐Assembling Matrixes for Regulating Polarization of Macrophages and Enhance Repair of Myocardial Infarction.
Autorzy:
Yang, Lei (AUTHOR)
Yang, Li (AUTHOR)
Lu, Kongli (AUTHOR)
Su, Nan (AUTHOR)
Li, Xueqin (AUTHOR)
Guo, Shuoxiang (AUTHOR)
Xue, Song (AUTHOR)
Lian, Feng (AUTHOR)
Feng, Chuanliang (AUTHOR)
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Źródło:
Advanced Science. 11/14/2023, Vol. 10 Issue 32, p1-13. 13p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights.
Autorzy:
Elbadawi MM; Department of Chemistry, Graduate School of Science, Hiroshima University, Hiroshima, Japan.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Abd El-Hafeez AA; Pharmacology and Experimental Oncology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Somaa WR; Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Albohy A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The British University in Egypt (BUE), Cairo, Egypt.
Al-Rashood ST; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Agama KK; Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Elkaeed EB; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia.
Ghosh P; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Medicine, University of California San Diego, La Jolla, CA, USA.; Moores Comprehensive Cancer Center, University of California San Diego, La Jolla, CA, USA.; Veterans Affairs Medical Center, La Jolla, CA, USA.
Pommier Y; Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Abe M; Department of Chemistry, Graduate School of Science, Hiroshima University, Hiroshima, Japan.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 349-372.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Focal Adhesion Kinase 1/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Quinolines/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Focal Adhesion Kinase 1/metabolism ; Humans ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Quinolines/chemical synthesis ; Quinolines/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Role of proline-rich tyrosine kinase 2 (Pyk2) in the pathogenesis of Alzheimer's disease.
Autorzy:
Kumar R; Department of Biotechnology, GITAM Institute of Sciences, GITAM University, Visakhapatnam, India.
Tiwari V; Department of Biochemistry, Central University of Rajasthan, Ajmer, India.
Dey S; Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
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Źródło:
The European journal of neuroscience [Eur J Neurosci] 2022 Nov; Vol. 56 (9), pp. 5442-5452. Date of Electronic Publication: 2022 Jan 17.
Typ publikacji:
Review; Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Focal Adhesion Kinase 2*/metabolism
Aged ; Humans ; Neurofibrillary Tangles/metabolism ; Neurofibrillary Tangles/pathology ; Phosphorylation ; Plaque, Amyloid/metabolism ; tau Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Thrombin-Induced COX-2 Expression and PGE 2 Synthesis in Human Tracheal Smooth Muscle Cells: Role of PKCδ/Pyk2-Dependent AP-1 Pathway Modulation.
Autorzy:
Yang CC; Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital at Taoyuan, Taoyuan 333008, Taiwan.; School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.
Lee IT; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110301, Taiwan.
Lin YJ; Ph.D. Program for Biotech Pharmaceutical Industry, China Medical University, Taichung 406040, Taiwan.
Wu WB; School of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
Hsiao LD; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
Yang CM; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 13; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 13.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Transcription Factor AP-1*/metabolism
Humans ; CSK Tyrosine-Protein Kinase/metabolism ; Cyclooxygenase 2/metabolism ; Dinoprostone/metabolism ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Focal Adhesion Kinase 2/genetics ; Focal Adhesion Kinase 2/metabolism ; Inflammation/metabolism ; Myocytes, Smooth Muscle/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Resveratrol/pharmacology ; Resveratrol/metabolism ; src-Family Kinases/metabolism ; Thrombin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps.
Autorzy:
Maes, Margaret E. (AUTHOR)
Donahue, Ryan J. (AUTHOR)
Schlamp, Cassandra L. (AUTHOR)
Marola, Olivia J. (AUTHOR)
Libby, Richard T. (AUTHOR)
Nickells, Robert W. (AUTHOR)
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Źródło:
Molecular Neurodegeneration. 9/26/2023, Vol. 18 Issue 1, p1-22. 22p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 11209

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