Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""FUSION"" wg kryterium: Temat


Tytuł :
Myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm.
Autorzy :
Golani G; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel.
Leikina E; Section on Membrane Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
Melikov K; Section on Membrane Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
Whitlock JM; Section on Membrane Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
Gamage DG; Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Luoma-Overstreet G; Section on Membrane Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA.
Millay DP; Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati, Cincinnati, OH, 45229, USA.
Kozlov MM; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel. .
Chernomordik LV; Section on Membrane Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Jan 21; Vol. 12 (1), pp. 495. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Membrane Fusion*
Cell Membrane/*metabolism
Membrane Proteins/*metabolism
Myoblasts/*metabolism
Algorithms ; Animals ; Cell Fusion ; Cell Line ; Lipid Bilayers/metabolism ; Membrane Lipids/metabolism ; Membrane Proteins/genetics ; Mice ; Mice, Knockout ; Models, Theoretical ; Myoblasts/cytology ; NIH 3T3 Cells
Czasopismo naukowe
Tytuł :
Novel Roles of the N1 Loop and N4 Alpha-Helical Region of the Nipah Virus Fusion Glycoprotein in Modulating Early and Late Steps of the Membrane Fusion Cascade.
Autorzy :
Zamora JLR; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Ortega V; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Johnston GP; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Li J; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Aguilar HC; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA .
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2021 Apr 12; Vol. 95 (9). Date of Electronic Publication: 2021 Apr 12 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Membrane Fusion*
Virus Internalization*
Henipavirus Infections/*virology
Nipah Virus/*physiology
Viral Fusion Proteins/*chemistry
Animals ; Chlorocebus aethiops ; HEK293 Cells ; Humans ; Protein Conformation ; Protein Conformation, alpha-Helical ; Vero Cells
Czasopismo naukowe
Tytuł :
Myxoid mesenchymal intraventricular brain tumour with EWSR1-CREB1 gene fusion in an adult woman.
Autorzy :
Valente Aguiar P; Neurosurgery Department, Centro Hospitalar Universitário São João, Porto, Portugal. .; Faculty of Medicine, University of Porto, Porto, Portugal. .
Pinheiro J; IPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.; Department of Pathology, Centro Hospitalar Universitário São João, Porto, Portugal.
Lima J; Faculty of Medicine, University of Porto, Porto, Portugal.; Department of Pathology, Centro Hospitalar Universitário São João, Porto, Portugal.; i3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.
Vaz R; Neurosurgery Department, Centro Hospitalar Universitário São João, Porto, Portugal.; Faculty of Medicine, University of Porto, Porto, Portugal.; Neurosciences Centre, Hospital CUF, Porto, Portugal.
Linhares P; Neurosurgery Department, Centro Hospitalar Universitário São João, Porto, Portugal.; Faculty of Medicine, University of Porto, Porto, Portugal.; Neurosciences Centre, Hospital CUF, Porto, Portugal.
Pokaż więcej
Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 May; Vol. 478 (5), pp. 1019-1024. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :
Case Reports
MeSH Terms :
Gene Fusion*
Biomarkers, Tumor/*genetics
Cerebral Ventricle Neoplasms/*genetics
Histiocytoma, Malignant Fibrous/*genetics
Oncogene Proteins, Fusion/*genetics
Cerebral Ventricle Neoplasms/diagnostic imaging ; Cerebral Ventricle Neoplasms/pathology ; Cerebral Ventricle Neoplasms/surgery ; Female ; Histiocytoma, Malignant Fibrous/diagnostic imaging ; Histiocytoma, Malignant Fibrous/pathology ; Histiocytoma, Malignant Fibrous/surgery ; Humans ; Middle Aged ; Treatment Outcome
SCR Disease Name :
Histiocytoma, Angiomatoid Fibrous
Raport
Tytuł :
Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML).
Autorzy :
Lu T; Anhui Province Key Laboratory of Medical Physics and Technology; CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, Anhui, 230012, PR China.
Cao J; Anhui Province Key Laboratory of Medical Physics and Technology; CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; University of Science and Technology of China, Hefei, Anhui, 230026, PR China.
Zou F; Anhui Province Key Laboratory of Medical Physics and Technology; CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Li X; Anhui Province Key Laboratory of Medical Physics and Technology; CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Wang A; Anhui Province Key Laboratory of Medical Physics and Technology; CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Wang W; Anhui Province Key Laboratory of Medical Physics and Technology; CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Liang H; Anhui Province Key Laboratory of Medical Physics and Technology; CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Liu Q; Anhui Province Key Laboratory of Medical Physics and Technology; CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Hu C; Anhui Province Key Laboratory of Medical Physics and Technology; CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Chen C; Anhui Province Key Laboratory of Medical Physics and Technology; CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Hu Z; Anhui Province Key Laboratory of Medical Physics and Technology; CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Wang W; Anhui Province Key Laboratory of Medical Physics and Technology; CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Li L; Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, PR China.
Ge J; Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, PR China.
Shen Y; The First Hospital of Jiaxing, 1882 Zhonghuan South Rd, Jiaxing, Zhejiang, 314000, PR China.
Ren T; Anhui Province Key Laboratory of Medical Physics and Technology; CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China.
Liu J; Anhui Province Key Laboratory of Medical Physics and Technology; CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; University of Science and Technology of China, Hefei, Anhui, 230026, PR China.
Xia R; Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, PR China. Electronic address: .
Liu Q; Anhui Province Key Laboratory of Medical Physics and Technology; CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; University of Science and Technology of China, Hefei, Anhui, 230026, PR China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, 230031, PR China; Precision Medicine Research Laboratory of Anhui Province, Hefei, Anhui, 230088, PR China; Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230601, PR China. Electronic address: .
Pokaż więcej
Źródło :
European journal of pharmacology [Eur J Pharmacol] 2021 Apr 15; Vol. 897, pp. 173944. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Drug Resistance, Neoplasm/*drug effects
Fusion Proteins, bcr-abl/*antagonists & inhibitors
Imatinib Mesylate/*pharmacology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Animals ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Female ; Fusion Proteins, bcr-abl/genetics ; Fusion Proteins, bcr-abl/metabolism ; Gene Fusion ; Humans ; K562 Cells ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/enzymology ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Mice ; Mice, Nude ; Mutation ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
annoFuse: an R Package to annotate, prioritize, and interactively explore putative oncogenic RNA fusions.
Autorzy :
Gaonkar KS; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Marini F; Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.; Center for Thrombosis and Hemostasis, Mainz, Germany.
Rathi KS; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jain P; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Zhu Y; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Chimicles NA; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Brown MA; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Naqvi AS; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Zhang B; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Storm PB; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Maris JM; Division of Oncology, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Raman P; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Resnick AC; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Strauch K; Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Taroni JN; Alex's Lemonade Stand Foundation Childhood Cancer Data Lab, Philadelphia, PA, USA.
Rokita JL; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA. .; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. .; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA. .
Pokaż więcej
Źródło :
BMC bioinformatics [BMC Bioinformatics] 2020 Dec 14; Vol. 21 (1), pp. 577. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Fusion*
Software*
Neoplasms/*genetics
RNA/*metabolism
Algorithms ; Humans ; Neoplasms/pathology ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; RNA/genetics
Czasopismo naukowe
Tytuł :
Evolutionarily related small viral fusogens hijack distinct but modular actin nucleation pathways to drive cell-cell fusion.
Autorzy :
Chan KMC; University of California Berkeley/University of California San Francisco Graduate Group in Bioengineering, Berkeley, CA 94720.; Department of Bioengineering & Biophysics Group, University of California, Berkeley, CA 94720.; Physiology Course, Marine Biological Laboratory, Woods Hole, MA 02543.
Arthur AL; Physiology Course, Marine Biological Laboratory, Woods Hole, MA 02543.; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455.
Morstein J; Physiology Course, Marine Biological Laboratory, Woods Hole, MA 02543.; Department of Chemistry, New York University, New York, NY 10003.
Jin M; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Bhat A; Physiology Course, Marine Biological Laboratory, Woods Hole, MA 02543.; National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, 560065, India.
Schlesinger D; Physiology Course, Marine Biological Laboratory, Woods Hole, MA 02543.; Science for Life Laboratory, Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Division of Genome Biology, Stockholm 17165, Sweden.
Son S; Department of Bioengineering & Biophysics Group, University of California, Berkeley, CA 94720.; Physiology Course, Marine Biological Laboratory, Woods Hole, MA 02543.
Stevens DA; Physiology Course, Marine Biological Laboratory, Woods Hole, MA 02543.; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093.
Drubin DG; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Fletcher DA; University of California Berkeley/University of California San Francisco Graduate Group in Bioengineering, Berkeley, CA 94720; .; Department of Bioengineering & Biophysics Group, University of California, Berkeley, CA 94720.; Physiology Course, Marine Biological Laboratory, Woods Hole, MA 02543.; Division of Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.; Chan Zuckerberg Biohub, San Francisco, CA 94158.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 05; Vol. 118 (1).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Actins/*metabolism
Membrane Fusion/*physiology
Membrane Fusion Proteins/*metabolism
Actin Cytoskeleton/metabolism ; Amino Acid Sequence/genetics ; Animals ; Biological Evolution ; Cell Fusion/methods ; Cell Line ; Cell Membrane/metabolism ; Cytoskeleton/metabolism ; Evolution, Molecular ; Humans ; Orthoreovirus/genetics ; Protein Binding/genetics ; Reoviridae/genetics ; Viral Fusion Proteins/chemistry ; Viral Fusion Proteins/metabolism ; Viral Nonstructural Proteins/metabolism ; Virus Internalization
Czasopismo naukowe
Tytuł :
Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell-cell fusion.
Autorzy :
Thakur N; The Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.
Conceicao C; The Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.
Isaacs A; University of Queensland, Brisbane, Queensland 4071, Australia.
Human S; The Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.
Modhiran N; University of Queensland, Brisbane, Queensland 4071, Australia.
McLean RK; The Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.
Pedrera M; The Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.
Tan TK; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Rijal P; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Townsend A; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Taylor G; The Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.
Young PR; University of Queensland, Brisbane, Queensland 4071, Australia.
Watterson D; University of Queensland, Brisbane, Queensland 4071, Australia.
Chappell KJ; University of Queensland, Brisbane, Queensland 4071, Australia.
Graham SP; The Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.
Bailey D; The Pirbright Institute, Ash Road, Pirbright, Woking, GU24 0NF, UK.
Pokaż więcej
Źródło :
The Journal of general virology [J Gen Virol] 2021 Jan; Vol. 102 (1). Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
High-Throughput Screening Assays*
Antibodies, Neutralizing/*pharmacology
Antibodies, Viral/*pharmacology
COVID-19/*diagnosis
Henipavirus Infections/*diagnosis
Respiratory Syncytial Virus Infections/*diagnosis
Viral Fusion Proteins/*antagonists & inhibitors
Animals ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Neutralizing/metabolism ; Antibodies, Viral/isolation & purification ; Antibodies, Viral/metabolism ; COVID-19/immunology ; COVID-19/virology ; Cell Fusion ; Convalescence ; Genes, Reporter ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; HEK293 Cells ; Henipavirus Infections/immunology ; Henipavirus Infections/virology ; Humans ; Immune Sera/chemistry ; Luciferases/genetics ; Luciferases/metabolism ; Models, Molecular ; Nipah Virus/immunology ; Nipah Virus/pathogenicity ; Protein Conformation ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus Infections/virology ; Respiratory Syncytial Virus, Human/immunology ; Respiratory Syncytial Virus, Human/pathogenicity ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Swine ; Viral Fusion Protein Inhibitors/chemistry ; Viral Fusion Protein Inhibitors/metabolism ; Viral Fusion Protein Inhibitors/pharmacology ; Viral Fusion Proteins/genetics ; Viral Fusion Proteins/immunology
Czasopismo naukowe
Tytuł :
Roles of Cholesterol in Early and Late Steps of the Nipah Virus Membrane Fusion Cascade.
Autorzy :
Contreras EM; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Johnston GP; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Buchholz DW; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Ortega V; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Monreal IA; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Zamora JLR; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Cheung T; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Aguilar HC; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA .
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2021 Feb 24; Vol. 95 (6). Date of Electronic Publication: 2021 Feb 24 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cholesterol/*metabolism
Membrane Fusion/*physiology
Nipah Virus/*physiology
Cholesterol/deficiency ; Giant Cells/metabolism ; Membrane Lipids/analysis ; Membrane Lipids/metabolism ; Nipah Virus/metabolism ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/metabolism ; Viral Fusion Proteins/genetics ; Viral Fusion Proteins/metabolism ; Virion/metabolism ; Virus Internalization
Czasopismo naukowe
Tytuł :
Human transcription factor and protein kinase gene fusions in human cancer.
Autorzy :
Salokas K; Systems Pathology/Biology Research Group, Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Weldatsadik RG; Systems Pathology/Biology Research Group, Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Varjosalo M; Systems Pathology/Biology Research Group, Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland. .
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2020 Aug 25; Vol. 10 (1), pp. 14169. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article
MeSH Terms :
Oncogene Fusion*/genetics
Neoplasms/*genetics
Oncogene Proteins, Fusion/*genetics
Protein Kinases/*genetics
Transcription Factors/*genetics
Carcinogenesis/genetics ; Chromosomes, Human/genetics ; Chromosomes, Human/ultrastructure ; Datasets as Topic ; Gene Expression Regulation, Neoplastic/genetics ; Genes, Neoplasm ; Humans ; Metabolic Networks and Pathways/genetics ; Oncogene Proteins, Fusion/metabolism ; Open Reading Frames/genetics ; Protein Domains/genetics ; Protein Kinases/metabolism ; Signal Transduction/genetics ; Structure-Activity Relationship ; Transcription Factors/metabolism ; Translocation, Genetic
Czasopismo naukowe
Tytuł :
Experimental Evolution To Isolate Vaccinia Virus Adaptive G9 Mutants That Overcome Membrane Fusion Inhibition via the Vaccinia Virus A56/K2 Protein Complex.
Autorzy :
Hong GC; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China.; Genome and Systems Biology Degree Program, Academia Sinica and National Taiwan University, Taipei, Taiwan, Republic of China.
Tsai CH; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China.
Chang W; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China .; Genome and Systems Biology Degree Program, Academia Sinica and National Taiwan University, Taipei, Taiwan, Republic of China.
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2020 May 04; Vol. 94 (10). Date of Electronic Publication: 2020 May 04 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Membrane Fusion*
Mutation*
Vaccinia virus/*genetics
Vaccinia virus/*isolation & purification
Viral Proteins/*genetics
Cell Fusion ; Cell Membrane ; Evolution, Molecular ; Gene Expression Regulation, Viral ; Genes, Viral/genetics ; Genome, Viral ; HeLa Cells ; Humans ; Recombinant Proteins ; Vaccinia virus/growth & development ; Viral Fusion Proteins/genetics ; Viral Fusion Proteins/isolation & purification ; Viral Proteins/isolation & purification ; Virus Internalization
Czasopismo naukowe
Tytuł :
Beneficial tyrosine kinase inhibitor therapy in a patient with relapsed BCR-ABL1-like acute lymphoblastic leukemia with CCDC88C-PDGFRB fusion.
Autorzy :
Oya S; Division of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
Morishige S; Division of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
Ozawa H; Division of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
Sasaki K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, 812-8582, Japan.
Semba Y; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, 812-8582, Japan.
Yamasaki Y; Division of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
Nakamura T; Division of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
Aoyama K; Division of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
Seki R; Division of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
Mouri F; Division of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
Osaki K; Division of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
Miyamoto T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, 812-8582, Japan.
Maeda T; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, 812-8582, Japan.
Nagafuji K; Division of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan. .
Pokaż więcej
Źródło :
International journal of hematology [Int J Hematol] 2021 Feb; Vol. 113 (2), pp. 285-289. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Intracellular Signaling Peptides and Proteins/*genetics
Microfilament Proteins/*genetics
Oncogene Proteins, Fusion/*genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
Protein Kinase Inhibitors/*therapeutic use
Receptor, Platelet-Derived Growth Factor beta/*genetics
Biomarkers ; Combined Modality Therapy ; Female ; Fusion Proteins, bcr-abl/genetics ; Genetic Testing ; Humans ; Molecular Targeted Therapy/adverse effects ; Molecular Targeted Therapy/methods ; Neoplasm, Residual/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/adverse effects ; Recurrence ; Retreatment ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
A fusion of CD63-BCAR4 identified in lung adenocarcinoma promotes tumorigenicity and metastasis.
Autorzy :
Bae K; College of Veterinary Medicine, Konkuk University, Seoul, 05029, Republic of Korea.
Kim JH; College of Health Science, Cheongju University, Cheongju, 28503, Republic of Korea.
Jung H; College of Veterinary Medicine, Konkuk University, Seoul, 05029, Republic of Korea.
Kong SY; National Cancer Center Graduate School of Cancer Science and Policy, Goyang, 10408, Gyeonggi, Republic of Korea.; Research Institute, National Cancer Center, Goyang, 10408, Gyeonggi, Republic of Korea.; Hospital, National Cancer Center, Goyang, 10408, Gyeonggi, Republic of Korea.
Kim YH; National Cancer Center Graduate School of Cancer Science and Policy, Goyang, 10408, Gyeonggi, Republic of Korea.; Research Institute, National Cancer Center, Goyang, 10408, Gyeonggi, Republic of Korea.
Kim S; Research Institute, National Cancer Center, Goyang, 10408, Gyeonggi, Republic of Korea.
Lee GK; Research Institute, National Cancer Center, Goyang, 10408, Gyeonggi, Republic of Korea.; Hospital, National Cancer Center, Goyang, 10408, Gyeonggi, Republic of Korea.
Lee JS; National Cancer Center Graduate School of Cancer Science and Policy, Goyang, 10408, Gyeonggi, Republic of Korea.
Lee JJ; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA.
Ju YS; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.
Choi YK; College of Veterinary Medicine, Konkuk University, Seoul, 05029, Republic of Korea.
Yoon KA; College of Veterinary Medicine, Konkuk University, Seoul, 05029, Republic of Korea. .
Pokaż więcej
Źródło :
British journal of cancer [Br J Cancer] 2021 Jan; Vol. 124 (1), pp. 290-298. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma of Lung/*genetics
Lung Neoplasms/*genetics
Oncogene Fusion/*genetics
RNA, Long Noncoding/*genetics
Tetraspanin 30/*genetics
Adenocarcinoma of Lung/pathology ; Animals ; Carcinogenesis/genetics ; Cell Movement ; Heterografts ; Humans ; Lung Neoplasms/pathology ; Mice ; Oncogene Proteins, Fusion/genetics
Czasopismo naukowe
Tytuł :
Acidic pH-Induced Conformational Changes in Chikungunya Virus Fusion Protein E1: a Spring-Twisted Region in the Domain I-III Linker Acts as a Hinge Point for Swiveling Motion of Domains.
Autorzy :
Sahoo B; School of Biological Sciences, National Institute of Science Education and Research (NISER), Homi Bhabha National Institute (HBNI), Bhubaneswar, India.
Gudigamolla NK; School of Biological Sciences, National Institute of Science Education and Research (NISER), Homi Bhabha National Institute (HBNI), Bhubaneswar, India.
Chowdary TK; School of Biological Sciences, National Institute of Science Education and Research (NISER), Homi Bhabha National Institute (HBNI), Bhubaneswar, India .
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2020 Nov 09; Vol. 94 (23). Date of Electronic Publication: 2020 Nov 09 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Domains*
Chikungunya virus/*metabolism
Viral Fusion Proteins/*chemistry
Viral Fusion Proteins/*metabolism
Chikungunya Fever/virology ; Chikungunya virus/genetics ; Endocytosis ; Hydrogen-Ion Concentration ; Membrane Fusion ; Membrane Glycoproteins/chemistry ; Molecular Dynamics Simulation ; Protein Binding ; Protein Conformation ; Viral Envelope Proteins/chemistry ; Viral Envelope Proteins/metabolism ; Viral Fusion Proteins/genetics ; Virus Internalization
Czasopismo naukowe
Tytuł :
Fusogenicity of the Ghana Virus ( Henipavirus : Ghanaian bat henipavirus ) Fusion Protein is Controlled by the Cytoplasmic Domain of the Attachment Glycoprotein.
Autorzy :
Voigt K; Institute of Virology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Hoffmann M; Infection Biology Unit, German Primate Center-Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
Drexler JF; Institute of Virology, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 10117 Berlin, Germany.
Müller MA; Institute of Virology, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 10117 Berlin, Germany.
Drosten C; Institute of Virology, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 10117 Berlin, Germany.
Herrler G; Institute of Virology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Krüger N; Institute of Virology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany. .; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Germany. .
Pokaż więcej
Źródło :
Viruses [Viruses] 2019 Aug 29; Vol. 11 (9). Date of Electronic Publication: 2019 Aug 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Fusion*
Henipavirus/*metabolism
Viral Envelope Proteins/*chemistry
Viral Envelope Proteins/*metabolism
Viral Fusion Proteins/*metabolism
Animals ; Cell Line ; Chiroptera ; Chlorocebus aethiops ; HEK293 Cells ; Henipavirus/genetics ; Host Specificity ; Humans ; Protein Domains ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Sequence Deletion ; Vero Cells ; Viral Envelope Proteins/genetics ; Viral Fusion Proteins/genetics
Czasopismo naukowe
Tytuł :
Virus-Mediated Cell-Cell Fusion.
Autorzy :
Leroy H; Institut Cochin, Inserm U1016, 75014 Paris, France.; Centre National de la Recherche Scientifique CNRS, UMR8104, 75014 Paris, France.; Faculty of Health, University of Paris, 75014 Paris, France.
Han M; Institut Cochin, Inserm U1016, 75014 Paris, France.; Centre National de la Recherche Scientifique CNRS, UMR8104, 75014 Paris, France.; Faculty of Health, University of Paris, 75014 Paris, France.
Woottum M; Institut Cochin, Inserm U1016, 75014 Paris, France.; Centre National de la Recherche Scientifique CNRS, UMR8104, 75014 Paris, France.; Faculty of Health, University of Paris, 75014 Paris, France.
Bracq L; Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Bouchet J; Laboratory Orofacial Pathologies, Imaging and Biotherapies UR2496, University of Paris, 92120 Montrouge, France.
Xie M; Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
Benichou S; Institut Cochin, Inserm U1016, 75014 Paris, France.; Centre National de la Recherche Scientifique CNRS, UMR8104, 75014 Paris, France.; Faculty of Health, University of Paris, 75014 Paris, France.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 17; Vol. 21 (24). Date of Electronic Publication: 2020 Dec 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Fusion*
Membrane Fusion*
Virus Internalization*
Cell Membrane/*metabolism
Viral Fusion Proteins/*metabolism
Viruses/*metabolism
Animals ; Humans ; Viruses/isolation & purification
Czasopismo naukowe
Tytuł :
The Amino Acid at Position 8 of the Proteolytic Cleavage Site of the Mumps Virus Fusion Protein Affects Viral Proteolysis and Fusogenicity.
Autorzy :
Hüttl S; Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany.; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany.
Hoffmann M; Infection Biology Unit, German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany.; Faculty of Biology and Psychology, Georg August University Göttingen, Göttingen, Germany.
Steinmetzer T; Institute of Pharmaceutical Chemistry, Philipps University Marburg, Marburg, Germany.
Sauder C; Food and Drug Administration (FDA), Center for Biologics Evaluation and Research (CBER), Silver Spring, Maryland, USA.
Krüger N; Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany .; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany.; Infection Biology Unit, German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany.
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2020 Oct 27; Vol. 94 (22). Date of Electronic Publication: 2020 Oct 27 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteolysis*
Amino Acids/*chemistry
Mumps virus/*metabolism
Viral Fusion Proteins/*chemistry
Viral Fusion Proteins/*metabolism
Animals ; Cell Fusion ; Chlorocebus aethiops ; Furin/metabolism ; Genotype ; HEK293 Cells ; Humans ; Kinetics ; Mumps/virology ; Mumps virus/genetics ; Sequence Homology, Amino Acid ; Vero Cells ; Viral Fusion Proteins/genetics ; Virus Internalization
Czasopismo naukowe
Tytuł :
A viral fusogen hijacks the actin cytoskeleton to drive cell-cell fusion.
Autorzy :
Chan KMC; UC Berkeley-UC San Francisco Graduate Group in Bioengineering, Berkeley, United States.; Department of Bioengineering & Biophysics Graduate Group, University of California, Berkeley, Berkeley, United States.
Son S; Department of Bioengineering & Biophysics Graduate Group, University of California, Berkeley, Berkeley, United States.
Schmid EM; Department of Bioengineering & Biophysics Graduate Group, University of California, Berkeley, Berkeley, United States.
Fletcher DA; UC Berkeley-UC San Francisco Graduate Group in Bioengineering, Berkeley, United States.; Department of Bioengineering & Biophysics Graduate Group, University of California, Berkeley, Berkeley, United States.; Division of Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, United States.; Chan Zuckerberg Biohub, San Francisco, United States.
Pokaż więcej
Źródło :
ELife [Elife] 2020 May 22; Vol. 9. Date of Electronic Publication: 2020 May 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Fusion*
Actin Cytoskeleton/*metabolism
Viral Proteins/*metabolism
HEK293 Cells ; Humans ; Membrane Fusion Proteins/metabolism ; Orthoreovirus ; Protein Binding ; Protein Domains
Czasopismo naukowe
Tytuł :
Unique molecular features and clinical outcomes in young patients with non-small cell lung cancer harboring ALK fusion genes.
Autorzy :
Tian P; Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, Sichuan, China.; Lung Cancer Treatment Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Liu Y; Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, Sichuan, China.
Zeng H; Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, Sichuan, China.
Tang Y; Department of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Lizaso A; Burning Rock Biotech, Guangzhou, Guangdong, China.
Ye J; Burning Rock Biotech, Guangzhou, Guangdong, China.
Shao L; Burning Rock Biotech, Guangzhou, Guangdong, China.
Li Y; Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, Sichuan, China. .
Pokaż więcej
Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2020 Apr; Vol. 146 (4), pp. 935-944. Date of Electronic Publication: 2020 Jan 01.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Fusion*
Anaplastic Lymphoma Kinase/*genetics
Carcinoma, Non-Small-Cell Lung/*drug therapy
Carcinoma, Non-Small-Cell Lung/*genetics
Crizotinib/*therapeutic use
Lung Neoplasms/*drug therapy
Lung Neoplasms/*genetics
Adult ; Age Factors ; Antineoplastic Agents/therapeutic use ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/surgery ; DNA, Neoplasm/genetics ; Female ; Gene Rearrangement ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Oncogene Proteins, Fusion/genetics ; Progression-Free Survival ; Transcriptome ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells.
Autorzy :
Martinez-Lage M; Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029, Madrid, Spain.
Torres-Ruiz R; Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029, Madrid, Spain. .; Josep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, 08036, Barcelona, Spain. .
Puig-Serra P; Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029, Madrid, Spain.
Moreno-Gaona P; Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029, Madrid, Spain.
Martin MC; Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029, Madrid, Spain.
Moya FJ; Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029, Madrid, Spain.
Quintana-Bustamante O; Differentiation and Cytometry Unit, Hematopoietic Innovative Therapies Division, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER), 28040, Madrid, Spain.; Advanced Therapies Mixed Unit, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD, UAM), 28040, Madrid, Spain.
Garcia-Silva S; Microenvironment and Metastasis Group, Molecular Oncology Program, Spanish National Cancer Research Centre, 28029, Madrid, Spain.
Carcaboso AM; Institut de Recerca Sant Joan de Deu, Barcelona, Spain.; Department of Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, 08950, Barcelona, Spain.
Petazzi P; Josep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, 08036, Barcelona, Spain.
Bueno C; Josep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, 08036, Barcelona, Spain.
Mora J; Institut de Recerca Sant Joan de Deu, Barcelona, Spain.; Department of Pediatric Hematology and Oncology, Hospital Sant Joan de Deu, 08950, Barcelona, Spain.
Peinado H; Microenvironment and Metastasis Group, Molecular Oncology Program, Spanish National Cancer Research Centre, 28029, Madrid, Spain.
Segovia JC; Differentiation and Cytometry Unit, Hematopoietic Innovative Therapies Division, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER), 28040, Madrid, Spain.; Advanced Therapies Mixed Unit, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD, UAM), 28040, Madrid, Spain.
Menendez P; Josep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, 08036, Barcelona, Spain.; Instituciò Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluis Companys, 08010, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBER-ONC), ISCIII, Barcelona, Spain.
Rodriguez-Perales S; Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029, Madrid, Spain. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2020 Oct 08; Vol. 11 (1), pp. 5060. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CRISPR-Cas Systems/*genetics
Neoplasms/*genetics
Oncogene Fusion/*genetics
Animals ; Base Sequence ; Cell Line, Tumor ; Cell Proliferation/genetics ; Doxorubicin/therapeutic use ; Fusion Proteins, bcr-abl/genetics ; Gene Deletion ; Genetic Loci ; Genomic Instability ; HEK293 Cells ; Humans ; Introns/genetics ; Mice, Nude ; Neoplasms/drug therapy ; Neoplasms/pathology ; Oncogene Proteins, Fusion/genetics ; RNA, Guide/metabolism ; Reproducibility of Results ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV-2 spike (S) glycoprotein warranting further evaluation as an antiviral against COVID-19 infections.
Autorzy :
Musarrat F; Division of Biotechnology and Molecular Medicine, Louisiana State University, Baton Rouge, Louisiana.; Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana.
Chouljenko V; Division of Biotechnology and Molecular Medicine, Louisiana State University, Baton Rouge, Louisiana.; Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana.
Dahal A; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, Louisiana.
Nabi R; Division of Biotechnology and Molecular Medicine, Louisiana State University, Baton Rouge, Louisiana.; Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana.
Chouljenko T; Louisiana State University Agricultural Center, Agricultural Biotechnology Laboratory, Baton Rouge, Louisiana.
Jois SD; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, Louisiana.
Kousoulas KG; Division of Biotechnology and Molecular Medicine, Louisiana State University, Baton Rouge, Louisiana.; Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana.
Pokaż więcej
Źródło :
Journal of medical virology [J Med Virol] 2020 Oct; Vol. 92 (10), pp. 2087-2095. Date of Electronic Publication: 2020 May 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents/*pharmacology
Membrane Fusion/*drug effects
Nelfinavir/*pharmacology
SARS Virus/*drug effects
SARS-CoV-2/*drug effects
Spike Glycoprotein, Coronavirus/*antagonists & inhibitors
Animals ; Anti-HIV Agents/chemistry ; Binding Sites ; COVID-19/drug therapy ; Cell Fusion ; Chlorocebus aethiops ; Giant Cells/drug effects ; Giant Cells/pathology ; Giant Cells/virology ; Humans ; Molecular Docking Simulation ; Nelfinavir/chemistry ; Plasmids/chemistry ; Plasmids/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; SARS Virus/pathogenicity ; SARS Virus/physiology ; SARS-CoV-2/pathogenicity ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Vero Cells ; Virion/drug effects ; Virion/pathogenicity ; Virion/physiology
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies