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Wyszukujesz frazę ""Fab"" wg kryterium: Temat


Tytuł:
Strategies for the production of isotopically labelled Fab fragments of therapeutic antibodies in Komagataella phaffii (Pichia pastoris) and Escherichia coli for NMR studies.
Autorzy:
Gagné D; Regulatory Research Division, Center for Oncology, Radiopharmaceuticals and Research, Health Canada, Ottawa, ON, Canada.
Sarker M; Regulatory Research Division, Center for Oncology, Radiopharmaceuticals and Research, Health Canada, Ottawa, ON, Canada.
Gingras G; Regulatory Research Division, Center for Oncology, Radiopharmaceuticals and Research, Health Canada, Ottawa, ON, Canada.
Hodgson DJ; Regulatory Research Division, Center for Oncology, Radiopharmaceuticals and Research, Health Canada, Ottawa, ON, Canada.
Frahm G; Regulatory Research Division, Center for Oncology, Radiopharmaceuticals and Research, Health Canada, Ottawa, ON, Canada.
Creskey M; Regulatory Research Division, Center for Oncology, Radiopharmaceuticals and Research, Health Canada, Ottawa, ON, Canada.
Lorbetskie B; Regulatory Research Division, Center for Oncology, Radiopharmaceuticals and Research, Health Canada, Ottawa, ON, Canada.
Bigelow S; Regulatory Research Division, Center for Oncology, Radiopharmaceuticals and Research, Health Canada, Ottawa, ON, Canada.
Wang J; Regulatory Research Division, Center for Oncology, Radiopharmaceuticals and Research, Health Canada, Ottawa, ON, Canada.
Zhang X; Regulatory Research Division, Center for Oncology, Radiopharmaceuticals and Research, Health Canada, Ottawa, ON, Canada.
Johnston MJW; Regulatory Research Division, Center for Oncology, Radiopharmaceuticals and Research, Health Canada, Ottawa, ON, Canada.; Department of Chemistry, Carleton University, Ottawa, ON, Canada.
Lu H; Regulatory Research Division, Center for Oncology, Radiopharmaceuticals and Research, Health Canada, Ottawa, ON, Canada.
Aubin Y; Regulatory Research Division, Center for Oncology, Radiopharmaceuticals and Research, Health Canada, Ottawa, ON, Canada.; Department of Chemistry, Carleton University, Ottawa, ON, Canada.
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Źródło:
PloS one [PLoS One] 2023 Nov 29; Vol. 18 (11), pp. e0294406. Date of Electronic Publication: 2023 Nov 29 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Immunoglobulin Fab Fragments*/genetics
Immunoglobulin Fab Fragments*/chemistry
Escherichia coli*/genetics
Pichia ; Adalimumab/therapeutic use ; Carbon Isotopes ; Antibodies, Monoclonal ; Trastuzumab
SCR Organism:
Komagataella phaffii; Komagataella pastoris
Czasopismo naukowe
Tytuł:
Crystal structures and molecular dynamics simulations of a humanised antibody fragment at acidic to basic pH.
Autorzy:
Tang J; UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK.
Zhang C; Department of Biochemical Engineering, UCL, Bernard Katz Building, Gower Street, London, WC1E 6BT, UK.
Castillo NC; Department of Biochemical Engineering, UCL, Bernard Katz Building, Gower Street, London, WC1E 6BT, UK.
Lalaurie CJ; Department of Biochemical Engineering, UCL, Bernard Katz Building, Gower Street, London, WC1E 6BT, UK.
Gao X; Division of Biosciences, Department of Structural and Molecular Biology, UCL, London, WC1E 6BT, UK.
Dalby PA; Department of Biochemical Engineering, UCL, Bernard Katz Building, Gower Street, London, WC1E 6BT, UK. .
Kozielski F; UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK. .
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 28; Vol. 13 (1), pp. 16281. Date of Electronic Publication: 2023 Sep 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Molecular Dynamics Simulation*
Immunoglobulin Fab Fragments*/chemistry
Humans ; X-Ray Diffraction ; Protein Conformation ; Scattering, Small Angle
Czasopismo naukowe
Tytuł:
Genotyped functional screening of soluble Fab clones enables in-depth analysis of mutation effects.
Autorzy:
Oksanen S; Department of Life Sciences, University of Turku, 20520, Turku, Finland. .
Saarinen R; Department of Life Sciences, University of Turku, 20520, Turku, Finland.
Korkiakoski A; Department of Life Sciences, University of Turku, 20520, Turku, Finland.
Lamminmäki U; Department of Life Sciences, University of Turku, 20520, Turku, Finland.
Huovinen T; Department of Life Sciences, University of Turku, 20520, Turku, Finland. .
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Źródło:
Scientific reports [Sci Rep] 2023 Aug 11; Vol. 13 (1), pp. 13107. Date of Electronic Publication: 2023 Aug 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Monoclonal*
Immunoglobulin Fab Fragments*/chemistry
Mutation ; Cell Surface Display Techniques ; Peptide Library
Czasopismo naukowe
Tytuł:
Structural mechanism of Fab domain dissociation as a measure of interface stability.
Autorzy:
Pomarici ND; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.
Waibl F; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.
Quoika PK; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.; Center for Protein Assemblies (CPA), Physics Department, Chair of Theoretical Biophysics, Technical University of Munich, Ernst-Otto-Fischer-Str. 8, 85748, Garching, Germany.
Bujotzek A; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Nonnenwald 2, 82377, Penzberg, Germany.
Georges G; Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Nonnenwald 2, 82377, Penzberg, Germany.
Fernández-Quintero ML; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria. .
Liedl KR; Institute of General, Inorganic and Theoretical Chemistry, and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria. .
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Źródło:
Journal of computer-aided molecular design [J Comput Aided Mol Des] 2023 Apr; Vol. 37 (4), pp. 201-215. Date of Electronic Publication: 2023 Mar 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Immunoglobulin Fab Fragments*/chemistry
Immunoglobulin Fab Fragments*/metabolism
Antibodies*
Czasopismo naukowe
Tytuł:
Successful management of massive digoxin overdose using DIGIFab and therapeutic plasma exchange: a case report.
Autorzy:
Alhussein RM; Department of Emergency Medicine, King Saud University, Medical City, Riyadh, Saudi Arabia. .
Alamri NA; Department of Emergency Medicine, King Saud University, Medical City, Riyadh, Saudi Arabia.
Alhashem HM; Department of Emergency Medicine, King Saud University, Medical City, Riyadh, Saudi Arabia.
Alarifi MI; Department of Critical Care Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Alyahya B; Department of Emergency Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
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Źródło:
Journal of medical case reports [J Med Case Rep] 2024 Mar 05; Vol. 18 (1), pp. 135. Date of Electronic Publication: 2024 Mar 05.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Plasma Exchange*
Plasmapheresis*
Male ; Humans ; Adolescent ; Immunoglobulin Fab Fragments ; Digoxin
Czasopismo naukowe
Tytuł:
IgG1 and IgG4 antibodies sample initial structure dependent local conformational states and exhibit non-identical Fab dynamics.
Autorzy:
Natesan R; Process Development, Amgen Inc., 360 Binney St, Cambridge, MA, 02141, USA.
Agrawal NJ; Process Development, Amgen Inc., 360 Binney St, Cambridge, MA, 02141, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 23; Vol. 13 (1), pp. 4791. Date of Electronic Publication: 2023 Mar 23.
Typ publikacji:
Journal Article
MeSH Terms:
Immunoglobulin G*
Immunoglobulin Fab Fragments*/chemistry
Molecular Conformation ; Immunoglobulin Fc Fragments/metabolism
Czasopismo naukowe
Tytuł:
Effect of an intermolecular disulfide bond introduced into the first loop of CH1 domain of Adalimumab Fab on thermal stability and antigen-binding activity.
Autorzy:
Yoshikawa M; Department of Biochemistry, Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
Nakamura H; Department of Biochemistry, Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
Oda-Ueda N; Department of Biochemistry, Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
Ueda T; Department of Protein Structure, Function and Design, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Ohkuri T; Department of Biochemistry, Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
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Źródło:
Journal of biochemistry [J Biochem] 2022 Jun 28; Vol. 172 (1), pp. 49-56.
Typ publikacji:
Journal Article
MeSH Terms:
Disulfides*/chemistry
Immunoglobulin Fab Fragments*/genetics
Adalimumab/genetics
Czasopismo naukowe
Tytuł:
Non-covalent Fc-Fab interactions significantly alter internal dynamics of an IgG1 antibody.
Autorzy:
Natesan R; Amgen Inc., Process Development, 360 Binney St, Cambridge, MA, 02141, USA.
Agrawal NJ; Amgen Inc., Process Development, 360 Binney St, Cambridge, MA, 02141, USA. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jun 04; Vol. 12 (1), pp. 9321. Date of Electronic Publication: 2022 Jun 04.
Typ publikacji:
Journal Article
MeSH Terms:
Immunoglobulin Fab Fragments*/chemistry
Immunoglobulin G*
Humans ; Immunoglobulin Fc Fragments/chemistry
Czasopismo naukowe
Tytuł:
Mechanistic modeling of a human IgG 4 monoclonal antibody (tralokinumab) Fab-arm exchange with endogenous IgG 4 in healthy volunteers.
Autorzy:
Wang B; Amador Bioscience, Pleasanton, California, USA.
Goodman J; Clinical Pharmacology and Safety Sciences, AstraZeneca, BioPharmaceuticals, R&D, Cambridge, UK.
Roskos LK; Clinical Pharmacology and Safety Sciences, AstraZeneca, BioPharmaceuticals, R&D, Gaithersburg, Maryland, USA.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2022 Apr; Vol. 11 (4), pp. 438-446. Date of Electronic Publication: 2022 Jan 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Monoclonal*/pharmacology
Immunoglobulin Fab Fragments*
Healthy Volunteers ; Humans ; Immunoglobulin G ; Infant, Newborn
Czasopismo naukowe
Tytuł:
NANOBODY Molecule, a Giga Medical Tool in Nanodimensions.
Autorzy:
Kunz S; Université Côte d'Azur, CNRS UMR7284, INSERM U1081, IRCAN, 06107 Nice, France.; Department of Oncology, Sanofi Research Center, 94400 Vitry-sur-Seine, France.
Durandy M; Université Côte d'Azur, CNRS UMR7284, INSERM U1081, IRCAN, 06107 Nice, France.
Seguin L; Université Côte d'Azur, CNRS UMR7284, INSERM U1081, IRCAN, 06107 Nice, France.
Feral CC; Université Côte d'Azur, CNRS UMR7284, INSERM U1081, IRCAN, 06107 Nice, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 25; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Antibodies, Monoclonal*/therapeutic use
Biomedical Research*
Excipients ; Fluorescent Dyes ; Immunoglobulin Fab Fragments ; Immunoglobulin Heavy Chains
Czasopismo naukowe
Tytuł:
The Deleterious Effects of Shiga Toxin Type 2 Are Neutralized In Vitro by FabF8:Stx2 Recombinant Monoclonal Antibody.
Autorzy:
Luz D; Laboratório de Bacteriologia, Instituto Butantan, Sao Paulo 05503-900, Brazil.
Gómez FD; Laboratorio de Fisiopatogenia, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay-CONICET), Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires 1121, Argentina.
Ferreira RL; Laboratório de Bacteriologia, Instituto Butantan, Sao Paulo 05503-900, Brazil.
Melo BS; Laboratório de Bacteriologia, Instituto Butantan, Sao Paulo 05503-900, Brazil.
Guth BEC; Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sāo Paulo, Sao Paulo 04023-062, Brazil.
Quintilio W; Laboratório de Biofármacos, Instituto Butantan, Sao Paulo 05503-900, Brazil.
Moro AM; Laboratório de Biofármacos, Instituto Butantan, Sao Paulo 05503-900, Brazil.
Presta A; Laboratorio de Fisiopatogenia, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay-CONICET), Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires 1121, Argentina.
Sacerdoti F; Laboratorio de Fisiopatogenia, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay-CONICET), Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires 1121, Argentina.
Ibarra C; Laboratorio de Fisiopatogenia, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay-CONICET), Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires 1121, Argentina.
Chen G; Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, OT M5S 3E1, Canada.
Sidhu SS; Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, OT M5S 3E1, Canada.
Amaral MM; Laboratorio de Fisiopatogenia, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay-CONICET), Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires 1121, Argentina.
Piazza RMF; Laboratório de Bacteriologia, Instituto Butantan, Sao Paulo 05503-900, Brazil.
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Źródło:
Toxins [Toxins (Basel)] 2021 Nov 22; Vol. 13 (11). Date of Electronic Publication: 2021 Nov 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Monoclonal/*pharmacology
Hemolytic-Uremic Syndrome/*prevention & control
Immunoglobulin Fab Fragments/*immunology
Shiga Toxin 2/*immunology
Animals ; Antibodies, Monoclonal/administration & dosage ; Apoptosis/drug effects ; Chlorocebus aethiops ; Dose-Response Relationship, Drug ; Epithelial Cells/drug effects ; Epithelial Cells/pathology ; Humans ; Immunoglobulin Fab Fragments/administration & dosage ; Kidney Glomerulus/cytology ; Kidney Glomerulus/drug effects ; Kidney Glomerulus/pathology ; Recombinant Proteins ; Shiga Toxin 1/immunology ; Shiga Toxin 1/toxicity ; Shiga Toxin 2/toxicity ; Shiga-Toxigenic Escherichia coli/immunology ; Vero Cells
Czasopismo naukowe
Tytuł:
Dramatic activation of an antibody by a single amino acid change in framework.
Autorzy:
Liang WC; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Yin J; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Lupardus P; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Zhang J; Department of Biochemical and Cellular Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA.
Loyet KM; Department of Biochemical and Cellular Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA.
Sudhamsu J; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. .; Department of Discovery Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. .
Wu Y; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Nov 16; Vol. 11 (1), pp. 22365. Date of Electronic Publication: 2021 Nov 16.
Typ publikacji:
Journal Article
MeSH Terms:
Amino Acid Substitution*
Antibodies, Monoclonal, Humanized/*chemistry
Immunoglobulin Fab Fragments/*chemistry
Immunoglobulin Variable Region/*chemistry
Transforming Growth Factor beta2/*chemistry
Transforming Growth Factor beta3/*chemistry
Animals ; Antibodies, Monoclonal, Humanized/genetics ; Crystallography, X-Ray ; Humans ; Immunoglobulin Fab Fragments/genetics ; Immunoglobulin Variable Region/genetics ; Protein Structure, Quaternary ; Rabbits ; Transforming Growth Factor beta2/genetics ; Transforming Growth Factor beta3/genetics
Czasopismo naukowe
Tytuł:
Computational redesign of Fab CC12.3 with substantially better predicted binding affinity to SARS-CoV-2 than human ACE2 receptor.
Autorzy:
Treewattanawong W; Structural and Computational Biology Research Unit, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand.
Sitthiyotha T; Structural and Computational Biology Research Unit, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand.
Chunsrivirot S; Structural and Computational Biology Research Unit, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand. .; Department of Biochemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand. .
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Źródło:
Scientific reports [Sci Rep] 2021 Nov 12; Vol. 11 (1), pp. 22202. Date of Electronic Publication: 2021 Nov 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Angiotensin-Converting Enzyme 2/*metabolism
Antibodies, Neutralizing/*metabolism
COVID-19/*metabolism
Immunoglobulin Fab Fragments/*metabolism
SARS-CoV-2/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Angiotensin-Converting Enzyme 2/chemistry ; Antibodies, Neutralizing/chemistry ; Binding Sites ; Humans ; Immunoglobulin Fab Fragments/chemistry ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Binding ; Protein Domains ; SARS-CoV-2/chemistry ; Spike Glycoprotein, Coronavirus/chemistry
Czasopismo naukowe
Tytuł:
Moderate-to-severe Vipera berus envenoming requiring ViperaTAb antivenom therapy in the UK.
Autorzy:
Lamb T; National Poisons Information Service - Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.; Myanmar Oxford Clinical Research Unit, University of Oxford, Oxford, UK.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Stewart D; National Poisons Information Service - Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.
Warrell DA; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Lalloo DG; Liverpool School of Tropical Medicine, Liverpool, UK.
Jagpal P; National Poisons Information Service - Birmingham, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
Jones D; National Poisons Information Service - Newcastle, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK.
Thanacoody R; National Poisons Information Service - Newcastle, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK.
Gray LA; National Poisons Information Service - Cardiff, University Hospital Llandough, Cardiff, UK.
Eddleston M; National Poisons Information Service - Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.; Department of Pharmacology, Toxicology, Therapeutics, University/BHF Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, UK.
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Źródło:
Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2021 Nov; Vol. 59 (11), pp. 992-1001. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji:
Journal Article
MeSH Terms:
Viperidae*/metabolism
Antivenins/*therapeutic use
Immunoglobulin Fab Fragments/*therapeutic use
Snake Bites/*drug therapy
Viper Venoms/*antagonists & inhibitors
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Antivenins/adverse effects ; Child ; Child, Preschool ; Databases, Factual ; Female ; Humans ; Immunoglobulin Fab Fragments/adverse effects ; Length of Stay ; Male ; Medical Audit ; Middle Aged ; Patient Admission ; Poison Control Centers ; Prospective Studies ; Severity of Illness Index ; Snake Bites/diagnosis ; Snake Bites/metabolism ; Time Factors ; Treatment Outcome ; United Kingdom ; Viper Venoms/metabolism ; Young Adult
Czasopismo naukowe
Tytuł:
Use of Crotalidae equine immune F(ab') 2 antivenom for treatment of an Agkistrodon envenomation.
Autorzy:
Wilson BZ; Department of Emergency Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Arizona Poison and Drug Information Center, University of Arizona, Tucson, AZ, USA.
Larsen J; Arizona Poison and Drug Information Center, University of Arizona, Tucson, AZ, USA.
Smelski G; Arizona Poison and Drug Information Center, University of Arizona, Tucson, AZ, USA.
Dudley S; Arizona Poison and Drug Information Center, University of Arizona, Tucson, AZ, USA.
Shirazi FM; Arizona Poison and Drug Information Center, University of Arizona, Tucson, AZ, USA.
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Źródło:
Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2021 Nov; Vol. 59 (11), pp. 1023-1026. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji:
Case Reports
MeSH Terms:
Agkistrodon*/metabolism
Antivenins/*therapeutic use
Crotalid Venoms/*antagonists & inhibitors
Immunoglobulin Fab Fragments/*therapeutic use
Snake Bites/*drug therapy
Aged ; Animals ; Antivenins/adverse effects ; Crotalid Venoms/metabolism ; Humans ; Immunoglobulin Fab Fragments/adverse effects ; Male ; Snake Bites/diagnosis ; Snake Bites/metabolism ; Treatment Outcome
Raport
Tytuł:
Glycosylation decreases aggregation and immunogenicity of adalimumab Fab secreted from Pichia pastoris.
Autorzy:
Nakamura H; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
Kiyoshi M; Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan.
Anraku M; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
Hashii N; Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan.
Oda-Ueda N; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
Ueda T; Department of Protein Structure, Function and Design, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
Ohkuri T; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
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Źródło:
Journal of biochemistry [J Biochem] 2021 Apr 29; Vol. 169 (4), pp. 435-443.
Typ publikacji:
Journal Article
MeSH Terms:
Adalimumab*/biosynthesis
Adalimumab*/genetics
Adalimumab*/immunology
Immunoglobulin Fab Fragments*/biosynthesis
Immunoglobulin Fab Fragments*/genetics
Immunoglobulin Fab Fragments*/immunology
Protein Aggregates*/genetics
Protein Aggregates*/immunology
Saccharomycetales*/genetics
Saccharomycetales*/immunology
Saccharomycetales*/metabolism
Animals ; Glycosylation ; Male ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology
SCR Organism:
Komagataella pastoris
Czasopismo naukowe
Tytuł:
Noninvasive evaluation of PD-L1 expression in non-small cell lung cancer by immunoPET imaging using an acylating agent-modified antibody fragment.
Autorzy:
Cheng Y; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
Shi D; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
Ye R; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
Fu W; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
Ma P; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
Si Z; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
Xu Z; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
Li L; Department of Hepatic Oncology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China.
Lin Q; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China. .; Institute of Nuclear Medicine, Fudan University, Shanghai, 200032, China. .; Shanghai Institute of Medical Imaging, Shanghai, 200032, China. .
Cheng D; Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai, 200032, China. .; Institute of Nuclear Medicine, Fudan University, Shanghai, 200032, China. .; Shanghai Institute of Medical Imaging, Shanghai, 200032, China. .
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Źródło:
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2023 May; Vol. 50 (6), pp. 1585-1596. Date of Electronic Publication: 2023 Feb 10.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*
Lung Neoplasms*/diagnostic imaging
Humans ; Immunoglobulin Fab Fragments/metabolism ; Tissue Distribution ; B7-H1 Antigen/metabolism ; Radiopharmaceuticals
Czasopismo naukowe
Tytuł:
Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants.
Autorzy:
Shitaoka K; Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Higashiura A; Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Kawano Y; Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Yamamoto A; Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Mizoguchi Y; Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Hashiguchi T; Laboratory of Medical Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Nishimichi N; Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.; Integrin-Matrix Biomedical Science, Translational Research Center, Hiroshima University, Hiroshima, Japan.
Huang S; Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Ito A; Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Ohki S; Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Kanda M; Collaborative laboratory of Liquid Biopsy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Taniguchi T; Division of General Internal Medicine and Infectious Diseases, Hiroshima Prefectural Hospital, Hiroshima, Japan.
Yoshizato R; Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Azuma H; Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Kitajima Y; Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Yokosaki Y; Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.; Integrin-Matrix Biomedical Science, Translational Research Center, Hiroshima University, Hiroshima, Japan.
Okada S; Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Sakaguchi T; Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Yasuda T; Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. .
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Źródło:
Communications biology [Commun Biol] 2023 Apr 11; Vol. 6 (1), pp. 395. Date of Electronic Publication: 2023 Apr 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
SARS-CoV-2*
COVID-19*
Humans ; Antibodies ; Immunoglobulin Fab Fragments
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Complex of human Melanotransferrin and SC57.32 Fab fragment reveals novel interdomain arrangement with ferric N-lobe and open C-lobe.
Autorzy:
Hayashi K; Research and Development, AbbVie Inc., South San Francisco, CA, 94080, USA.
Longenecker KL; Research and Development, AbbVie Inc., North Chicago, IL, 60064, USA.
Liu YL; Research and Development, AbbVie Inc., South San Francisco, CA, 94080, USA.
Faust B; Research and Development, AbbVie Inc., South San Francisco, CA, 94080, USA.
Prashar A; Research and Development, AbbVie Inc., South San Francisco, CA, 94080, USA.
Hampl J; Research and Development, AbbVie Inc., South San Francisco, CA, 94080, USA.
Stoll V; Research and Development, AbbVie Inc., North Chicago, IL, 60064, USA.
Vivona S; Research and Development, AbbVie Inc., South San Francisco, CA, 94080, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jan 12; Vol. 11 (1), pp. 566. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Domains*
Immunoglobulin Fab Fragments/*chemistry
Membrane Glycoproteins/*chemistry
Membrane Glycoproteins/*physiology
Acetylglucosamine ; Animals ; Biological Transport ; Blood-Brain Barrier/metabolism ; Drug Delivery Systems ; Drug Design ; Gene Expression ; Humans ; Immunoglobulin Fab Fragments/genetics ; Immunoglobulin Fab Fragments/metabolism ; Immunoglobulin Fab Fragments/physiology ; Iron/metabolism ; Macaca fascicularis ; Melanoma/etiology ; Melanoma/genetics ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Mice ; Protein Binding ; Triple Negative Breast Neoplasms/genetics
Czasopismo naukowe
Tytuł:
A comprehensive analysis of novel disulfide bond introduction site into the constant domain of human Fab.
Autorzy:
Nakamura H; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan.
Yoshikawa M; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan.
Oda-Ueda N; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan.
Ueda T; Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Ohkuri T; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto, 860-0082, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jun 21; Vol. 11 (1), pp. 12937. Date of Electronic Publication: 2021 Jun 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Molecular*
Protein Conformation*
Protein Interaction Domains and Motifs*/genetics
Disulfides/*chemistry
Immunoglobulin Fab Fragments/*chemistry
Antigens/chemistry ; Humans ; Immunoglobulin Fab Fragments/genetics ; Mutation ; Protein Binding ; Protein Stability ; Thermodynamics
Czasopismo naukowe

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