Autor: "Facchini FA" - OpacWWW

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Tytuł:: Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties.
Autorzy:: Cochet F; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza, 2, 20126, Milano, Italy.
Facchini FA; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza, 2, 20126, Milano, Italy.
Zaffaroni L; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza, 2, 20126, Milano, Italy.
Billod JM; Department of Structural and Chemical Biology, Centro de Investigaciones Biologicas, CIB-CSIC, Ramiro de Maeztu, 9, 28040, Madrid, Spain.
Coelho H; Molecular Recognition & Host-Pathogen Interactions Programme, CIC bioGUNE, Bizkaia Technology Park, Building 801 A, 48170, Derio, Spain.; UCIBIO, REQUIMTE, Departamento de Quimica, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829-516, Caparica, Portugal.; Department of Organic Chemistry II, Faculty of Science & Technology, University of the Basque Country, 48940, Leioa, Bizkaia, Spain.
Holgado A; Unit for Molecular Signal Transduction in Inflammation VIB-UGent Center for Inflammation Research, VIB Technologiepark 927, 9052, Zwijnaarde, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University Technologiepark 927, 9052, Zwijnaarde, Ghent, Belgium.
Braun H; Unit for Molecular Signal Transduction in Inflammation VIB-UGent Center for Inflammation Research, VIB Technologiepark 927, 9052, Zwijnaarde, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University Technologiepark 927, 9052, Zwijnaarde, Ghent, Belgium.
Beyaert R; Unit for Molecular Signal Transduction in Inflammation VIB-UGent Center for Inflammation Research, VIB Technologiepark 927, 9052, Zwijnaarde, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University Technologiepark 927, 9052, Zwijnaarde, Ghent, Belgium.
Jerala R; Department of Biotechnology, National Institute of Chemistry, Hajdrihova 19, 1000, Ljubljana, Slovenia.
Jimenez-Barbero J; Molecular Recognition & Host-Pathogen Interactions Programme, CIC bioGUNE, Bizkaia Technology Park, Building 801 A, 48170, Derio, Spain.; Department of Organic Chemistry II, Faculty of Science & Technology, University of the Basque Country, 48940, Leioa, Bizkaia, Spain.; Ikerbasque, Basque Foundation for Science, Maria Diaz de Haro 13, 48009, Bilbao, Spain.
Martin-Santamaria S; Department of Structural and Chemical Biology, Centro de Investigaciones Biologicas, CIB-CSIC, Ramiro de Maeztu, 9, 28040, Madrid, Spain.
Peri F; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza, 2, 20126, Milano, Italy. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Jan 29; Vol. 9 (1), pp. 919. Date of Electronic Publication: 2019 Jan 29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Glycolipids/*chemistry
Lymphocyte Antigen 96/*chemistry
Toll-Like Receptor 4/*chemistry
Animals ; Binding Sites ; Glycolipids/metabolism ; Glycolipids/pharmacology ; Humans ; Lymphocyte Antigen 96/metabolism ; Macrophages/drug effects ; Macrophages/metabolism ; Mice ; Molecular Conformation ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Structure ; Protein Binding ; Signal Transduction/drug effects ; Structure-Activity Relationship ; Toll-Like Receptor 4/antagonists & inhibitors

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