- Tytuł:
-
l-carnitine protects human hepatocytes from oxidative stress-induced toxicity through Akt-mediated activation of
Nrf2 signaling pathway. - Autorzy:
- Źródło:
- Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2016 May; Vol. 94 (5), pp. 517-25. Date of Electronic Publication: 2016 Feb 18.
- Typ publikacji:
- Journal Article
- MeSH Terms:
-
Oxidative Stress*/drug effects
Signal Transduction*/drug effects
Antioxidants/*metabolism
Carnitine/*metabolism
Hepatocytes/*metabolism
NF-E2-Related Factor 2/*agonists
Proto-Oncogene Proteins c-akt/*agonists
Active Transport, Cell Nucleus/drug effects ; Antioxidants/adverse effects ; Benzimidazoles/pharmacology ; Benzothiazoles/pharmacology ; Carnitine/adverse effects ; Cell Line ; Cell Survival/drug effects ; Dietary Supplements/adverse effects ; Electrophoretic Mobility Shift Assay ; Enzyme Activation/drug effects ; Heme Oxygenase-1/chemistry ; Heme Oxygenase-1/metabolism ; Hepatocytes/drug effects ; Humans ; Hydrogen Peroxide/antagonists & inhibitors ; Hydrogen Peroxide/toxicity ; NF-E2-Related Factor 2/antagonists & inhibitors ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Oxidants/antagonists & inhibitors ; Oxidants/toxicity ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/pharmacology ; Protein Processing, Post-Translational/drug effects ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/metabolism ; RNA Interference
Czasopismo naukowe