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Wyszukujesz frazę ""Factor VIIa"" wg kryterium: Temat


Tytuł:
Conformational Plasticity-Rigidity Axis of the Coagulation Factor VII Zymogen Elucidated by Atomistic Simulations of the N-Terminally Truncated Factor VIIa Protease Domain.
Autorzy:
Madsen JJ; Global and Planetary Health, College of Public Health, University of South Florida, Tampa, FL 33612, USA.
Olsen OH; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology, University of Copenhagen, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark.
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Źródło:
Biomolecules [Biomolecules] 2021 Apr 08; Vol. 11 (4). Date of Electronic Publication: 2021 Apr 08.
Typ publikacji:
Journal Article
MeSH Terms:
Factor VII/*chemistry
Factor VIIa/*chemistry
Protein Precursors/*chemistry
Allosteric Regulation ; Catalytic Domain ; Cluster Analysis ; Factor VII/metabolism ; Factor VIIa/metabolism ; Humans ; Molecular Dynamics Simulation ; Principal Component Analysis ; Protein Precursors/metabolism ; Protein Structure, Tertiary ; Thromboplastin/chemistry ; Thromboplastin/metabolism ; Trypsin/metabolism
Czasopismo naukowe
Tytuł:
Thrombin generation and platelet activation induced by rFVIIa (NovoSeven) and NN1731 in a reconstituted cell-based model mimicking haemophilia conditions.
Autorzy:
Aljamali MN; Haemostasis Pharmacology, Novo Nordisk, Maaloev, Denmark.
Kjalke M
Hedner U
Ezban M
Tranholm M
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Źródło:
Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2009 Nov; Vol. 15 (6), pp. 1318-26. Date of Electronic Publication: 2009 Jul 29.
Typ publikacji:
Evaluation Study; Journal Article
MeSH Terms:
Factor VII/*pharmacology
Factor VIIa/*pharmacology
Hemophilia A/*metabolism
Hemophilia B/*metabolism
Thrombin/*metabolism
Blood Coagulation Factors/pharmacology ; Cells, Cultured ; Dose-Response Relationship, Drug ; Factor VII/administration & dosage ; Factor VIIa/administration & dosage ; Humans ; Platelet Activation/drug effects ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/pharmacology ; Recombinant Proteins/therapeutic use ; Thrombin/drug effects
Czasopismo naukowe
Tytuł:
Activated FVII levels in factor VII Padua (Arg304Gln) coagulation disorder and in true factor VII deficiency: a study in homozygotes and heterozygotes.
Autorzy:
Girolami A; Department of Medical and Surgical Sciences, University of Padua Medical School, Via Ospedale 105, Padua, Italy. />Bertozzi I
de Marinis GB
Bonamigo E
Fabris F
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Źródło:
Hematology (Amsterdam, Netherlands) [Hematology] 2011 Sep; Vol. 16 (5), pp. 308-12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Heterozygote*
Homozygote*
Factor VII/*metabolism
Factor VII Deficiency/*genetics
Factor VII Deficiency/*metabolism
Factor VIIa/*metabolism
Adult ; Blood Coagulation Tests ; Female ; Humans ; Male ; Middle Aged ; Young Adult
Czasopismo naukowe
Tytuł:
Establishment of a cell line expressing recombinant factor VII and its subsequent conversion to active form FVIIa through hepsin by genetic engineering method.
Autorzy:
Halabian R; Research Center, Iranian Blood Transfusion Organization, Tehran, Iran.
Roudkenar MH
Esmaeili NS
Masroori N
Roushandeh AM
Najafabadi AJ
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Źródło:
Vox sanguinis [Vox Sang] 2009 May; Vol. 96 (4), pp. 309-15. Date of Electronic Publication: 2009 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Factor VII/*genetics
Factor VIIa/*metabolism
Genetic Engineering/*methods
Animals ; Blotting, Western ; CHO Cells ; Cell Line, Tumor ; Cloning, Molecular ; Cricetinae ; Cricetulus ; DNA, Complementary/genetics ; Enzyme-Linked Immunosorbent Assay ; Factor VII/biosynthesis ; Factor VII/metabolism ; Humans ; Prothrombin Time ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Serine Endopeptidases/biosynthesis ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Transfection/methods ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
Factor VII deficiency: defining the clinical picture and optimizing therapeutic options.
Autorzy:
Lapecorella M; Centro Emofilia e Trombosi, Unità Operativa Medicina Interna 2-Ematologia, Università de L'Aquila, Ospedale San Salvatore, Coppito, L'Aquila, Italy. />Mariani G
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Corporate Authors:
International Registry on Congenital Factor VII Deficiency
Źródło:
Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2008 Nov; Vol. 14 (6), pp. 1170-5.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Mutation*
Registries*
Factor VII/*physiology
Factor VII Deficiency/*genetics
Hemorrhage/*etiology
Age Factors ; Blood Coagulation/physiology ; Coagulants/therapeutic use ; Factor VII Deficiency/diagnosis ; Factor VII Deficiency/drug therapy ; Factor VIIa/therapeutic use ; Female ; Hemorrhage/drug therapy ; Humans ; Infant ; Infant, Newborn ; Male ; Pregnancy ; Prothrombin Time ; Randomized Controlled Trials as Topic ; Rare Diseases ; Recombinant Proteins/therapeutic use ; Severity of Illness Index
Czasopismo naukowe
Tytuł:
Management of haemophilic patients with inhibitors in major orthopaedic surgery by immunadsorption, substitution of factor VIII and recombinant factor VIIa (NovoSeven): a single centre experience.
Autorzy:
Habermann B; Department of Orthopaedic Surgery, University Hospital Frankfurt/Main, Germany.
Hochmuth K
Hovy L
Scharrer I
Kurth AH
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Źródło:
Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2004 Nov; Vol. 10 (6), pp. 705-12.
Typ publikacji:
Journal Article
MeSH Terms:
Orthopedic Procedures*
Blood Loss, Surgical/*prevention & control
Factor VII/*therapeutic use
Hemophilia A/*drug therapy
Recombinant Proteins/*therapeutic use
Adult ; Cohort Studies ; Factor VIII/analysis ; Factor VIII/antagonists & inhibitors ; Factor VIIa/analysis ; Factor VIIa/antagonists & inhibitors ; Fibrin Fibrinogen Degradation Products/analysis ; Hemostasis, Surgical ; Humans ; Immunosorbents ; Middle Aged ; Physical Therapy Modalities ; Preoperative Care/methods
Czasopismo naukowe
Tytuł:
Seminal factor VII and factor VIIa: supporting evidence for the presence of an active tissue factor-dependent coagulation pathway in human semen.
Autorzy:
Lwaleed BA; Department of Urology, Southampton University Hospitals NHS Trust, Southampton, UK. />Goyal A
Delves G
Gossai S
Greenfield RS
Cooper AJ
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Źródło:
International journal of andrology [Int J Androl] 2007 Dec; Vol. 30 (6), pp. 543-9. Date of Electronic Publication: 2007 Apr 24.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Factor VII/*analysis
Factor VIIa/*analysis
Fertility/*physiology
Semen/*chemistry
Seminal Vesicle Secretory Proteins/*analysis
Spermatozoa/*physiology
Thromboplastin/*analysis
Autoantibodies/analysis ; Humans ; Male ; Sexual Abstinence ; Sperm Agglutination ; Sperm Count ; Sperm Motility ; Spermatozoa/immunology ; Vasectomy
Czasopismo naukowe
Tytuł:
Successful graft patency after factor VIIa use for bleeding in coronary artery surgery: an unusual complication of a coronary artery bypass surgery.
Autorzy:
Wahed S; Department of Cardiothoracic Surgery, St. George's Hospital, London, United Kingdom. />Karagounis AP
Niranjan G
Kanagasabay R
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Źródło:
Journal of cardiac surgery [J Card Surg] 2007 Sep-Oct; Vol. 22 (5), pp. 424-7.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Hemostasis, Surgical*
Treatment Outcome*
Vascular Patency*
Coronary Artery Bypass/*adverse effects
Factor VII/*therapeutic use
Postoperative Complications/*drug therapy
Postoperative Hemorrhage/*drug therapy
Aged ; Factor VIIa ; Humans ; Male ; Postoperative Hemorrhage/etiology ; Recombinant Proteins/therapeutic use
Czasopismo naukowe
Tytuł:
Prophylactic treatment of haemophilia patients with inhibitors: clinical experience with recombinant factor VIIa in European Haemophilia Centres.
Autorzy:
Morfini M; Agency for Hemophilia, Azienda Ospedaliero Universitaria Careggi, Viale G.B. Morgagni No. 85, I-50134 Florence, Italy. />Auerswald G
Kobelt RA
Rivolta GF
Rodriguez-Martorell J
Scaraggi FA
Altisent C
Blatny J
Borel-Derlon A
Rossi V
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Źródło:
Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2007 Sep; Vol. 13 (5), pp. 502-7.
Typ publikacji:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Coagulants/*administration & dosage
Factor VII/*administration & dosage
Hemophilia A/*prevention & control
Hemorrhage/*prevention & control
Adolescent ; Adult ; Child ; Child, Preschool ; Europe ; Factor VIIa ; Female ; Hemarthrosis/prevention & control ; Humans ; Male ; Patient Compliance ; Recombinant Proteins/administration & dosage ; Retrospective Studies ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Utilization of recombinant activated factor VII in southern Ontario in 85 patients with and without haemophilia.
Autorzy:
Webert KE; Division of Hematology, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada. />Arnold DM
Carruthers J
Molnar L
Almonte T
Decker K
Seroski W
Reed J
Chan AK
Pai M
Walker IR
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Źródło:
Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2007 Sep; Vol. 13 (5), pp. 518-26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Blood Component Transfusion/*statistics & numerical data
Factor VII/*therapeutic use
Hemophilia A/*prevention & control
Hemorrhage/*prevention & control
Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Cohort Studies ; Drug Administration Routes ; Factor VIIa ; Female ; Hemophilia A/epidemiology ; Hemorrhage/epidemiology ; Humans ; Infant ; Male ; Middle Aged ; Ontario/epidemiology ; Recombinant Proteins/therapeutic use ; Retrospective Studies ; Treatment Outcome
Czasopismo naukowe
Tytuł:
A cost evaluation of treatment alternatives for mild-to-moderate bleeding episodes in patients with haemophilia and inhibitors in Brazil.
Autorzy:
Ozelo MC; Hemocentro da UNICAMP, Rua Carlos Chagas, CEP 13084-878 Campinas, São Paulo, Brazil. />Villaça PR
De Almeida JO
Bueno TM
De Miranda PA
Hart WM
Karamalis M
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Źródło:
Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2007 Sep; Vol. 13 (5), pp. 462-9.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Factor VII/*therapeutic use
Hemophilia A/*drug therapy
Hemorrhage/*prevention & control
Adolescent ; Adult ; Brazil ; Child ; Cohort Studies ; Cost of Illness ; Factor VII/economics ; Factor VIIa ; Female ; Hemophilia A/economics ; Hemorrhage/economics ; Humans ; Male ; Prospective Studies ; Recombinant Proteins/economics ; Recombinant Proteins/therapeutic use ; Retrospective Studies ; Treatment Outcome
Czasopismo naukowe
Tytuł:
A randomized, double-blind trial demonstrating bioequivalence of the current recombinant activated factor VII formulation and a new robust 25 degrees C stable formulation.
Autorzy:
Bysted BV; Clinical Pharmacology, Biopharm, Novo Nordisk A/S, Krogshøjvej 53A, DK-2880 Bagsvaerd, Denmark. />Scharling B
Møller T
Hansen BL
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Źródło:
Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2007 Sep; Vol. 13 (5), pp. 527-32.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Coagulants/*pharmacokinetics
Factor VII/*pharmacokinetics
Hemophilia A/*prevention & control
Hemophilia B/*prevention & control
Hemorrhage/*prevention & control
Adolescent ; Adult ; Analysis of Variance ; Cross-Over Studies ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drug Administration Schedule ; Factor VIIa ; Female ; Humans ; Male ; Middle Aged ; Recombinant Proteins/pharmacokinetics ; Therapeutic Equivalency
Czasopismo naukowe
Tytuł:
Treatment of acquired haemophilia with recombinant activated FVII: a critical appraisal.
Autorzy:
Sumner MJ; Novo Nordisk Inc., 100 College Road West, Princeton, NJ 08540, USA. />Geldziler BD
Pedersen M
Seremetis S
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Źródło:
Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2007 Sep; Vol. 13 (5), pp. 451-61.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Factor VII/*therapeutic use
Hemophilia A/*drug therapy
Hemorrhage/*prevention & control
Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Dose-Response Relationship, Drug ; Factor VIIa ; Female ; Humans ; Male ; Middle Aged ; Recombinant Proteins/therapeutic use ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Surgical interventions in a cohort of patients with haemophilia A and inhibitors: an experiential retrospective chart review.
Autorzy:
Kraut EH; Division of Hematology and Oncology, The Ohio State University, 320 West 10th Avenue, Columbus, OH 43210, USA. />Aledort LM
Arkin S
Stine KC
Wong WY
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Źródło:
Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2007 Sep; Vol. 13 (5), pp. 508-17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Blood Coagulation Factor Inhibitors/*metabolism
Blood Coagulation Factors/*administration & dosage
Blood Loss, Surgical/*prevention & control
Factor VII/*administration & dosage
Hemophilia A/*complications
Adult ; Blood Coagulation Factors/adverse effects ; Child, Preschool ; Drug Therapy, Combination ; Factor VII/adverse effects ; Factor VIIa ; Female ; Hemophilia A/immunology ; Humans ; Infant ; Male ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/adverse effects ; Retrospective Studies ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Successful treatment of severe gastrointestinal bleeding secondary to Crohn disease with recombinant factor VIIa.
Autorzy:
Girona E; Gastroenterology Section, Critical Care Unit, Hospital General Universitario de Elche, Spain.
Borrás-Blasco J
Conesa-García V
Navarro-Ruiz A
Solís J
García-Sepulcre MF
Oliver-García I
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Źródło:
Southern medical journal [South Med J] 2007 Jun; Vol. 100 (6), pp. 601-4.
Typ publikacji:
Case Reports; Journal Article; Review
MeSH Terms:
Crohn Disease/*complications
Factor VII/*therapeutic use
Gastrointestinal Hemorrhage/*drug therapy
Factor VIIa ; Gastrointestinal Hemorrhage/etiology ; Humans ; Male ; Middle Aged ; Recombinant Proteins/therapeutic use
Czasopismo naukowe
Tytuł:
Vitamin K deficiency bleeding after missed prophylaxis: rapid synergistic effect of vitamin K therapy on hemostasis.
Autorzy:
Clarke P
Shearer MJ
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Źródło:
Southern medical journal [South Med J] 2007 Jun; Vol. 100 (6), pp. 612-3.
Typ publikacji:
Letter; Comment
MeSH Terms:
Antifibrinolytic Agents/*pharmacology
Factor VII/*pharmacology
Vitamin K 1/*pharmacology
Vitamin K Deficiency Bleeding/*drug therapy
Antifibrinolytic Agents/therapeutic use ; Drug Synergism ; Factor VII/therapeutic use ; Factor VIIa ; Humans ; Infant, Newborn ; Recombinant Proteins/pharmacology ; Recombinant Proteins/therapeutic use ; Vitamin K 1/therapeutic use
Opinia redakcyjna
Tytuł:
Recombinant factor VIIa for severe gastrointestinal hemorrhage associated with Crohn disease.
Autorzy:
Filik L
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Źródło:
Southern medical journal [South Med J] 2007 Jun; Vol. 100 (6), pp. 559.
Typ publikacji:
Editorial; Comment
MeSH Terms:
Crohn Disease/*complications
Factor VII/*therapeutic use
Gastrointestinal Hemorrhage/*drug therapy
Factor VIIa ; Gastrointestinal Hemorrhage/etiology ; Humans ; Recombinant Proteins/therapeutic use
Opinia redakcyjna
Tytuł:
The potential role of recombinant activated FVII in the management of critical hemato-oncological bleeding: a systematic review.
Autorzy:
Franchini M; 1Servizio di Immunoematologia e Trasfusione - Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy. />Veneri D
Lippi G
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Źródło:
Bone marrow transplantation [Bone Marrow Transplant] 2007 Jun; Vol. 39 (12), pp. 729-35. Date of Electronic Publication: 2007 Apr 09.
Typ publikacji:
Journal Article; Review; Systematic Review
MeSH Terms:
Factor VII/*therapeutic use
Hemorrhage/*drug therapy
Leukemia/*complications
Blood Coagulation/drug effects ; Bone Marrow Transplantation ; Factor VIIa ; Hemorrhage/blood ; Hemorrhage/etiology ; Humans ; Leukemia/blood ; Leukemia/therapy ; Recombinant Proteins/therapeutic use
Czasopismo naukowe
Tytuł:
Sequential therapy with activated prothrombin complex concentrates and recombinant FVIIa in patients with severe haemophilia and inhibitors: update of our previous experience.
Autorzy:
Schneiderman J; Department of Pediatric Hematology, Children's Hospital of Orange County, Orange, CA, USA.
Rubin E
Nugent DJ
Young G
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Źródło:
Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2007 May; Vol. 13 (3), pp. 244-8.
Typ publikacji:
Journal Article
MeSH Terms:
Factor IX/*antagonists & inhibitors
Factor V/*therapeutic use
Factor VII/*therapeutic use
Factor Xa/*therapeutic use
Hemophilia A/*drug therapy
Recombinant Proteins/*therapeutic use
Drug Therapy, Combination ; Factor VIIa ; Humans
Czasopismo naukowe

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