Autor: "Fadda LM" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Curcumin and Nano-Curcumin Mitigate Copper Neurotoxicity by Modulating Oxidative Stress, Inflammation, and Akt/GSK-3β Signaling.
Autorzy:: Sarawi WS; Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Alhusaini AM; Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Fadda LM; Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Alomar HA; Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Albaker AB; Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Aljrboa AS; Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Alotaibi AM; Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.; Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Hasan IH; Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Mahmoud AM; Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2021 Sep 15; Vol. 26 (18). Date of Electronic Publication: 2021 Sep 15.
Typ publikacji:: Journal Article
MeSH Terms:: Anti-Inflammatory Agents/*therapeutic use
Antioxidants/*therapeutic use
Copper/*toxicity
Curcumin/*therapeutic use
Heavy Metal Poisoning/*drug therapy
Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/administration & dosage ; Antioxidants/pharmacology ; Apoptosis ; Brain/drug effects ; Brain/metabolism ; Curcumin/administration & dosage ; Curcumin/pharmacology ; Glycogen Synthase Kinase 3 beta/metabolism ; Heavy Metal Poisoning/etiology ; Interleukin-6/metabolism ; Male ; NF-kappa B/metabolism ; Nanoparticles/chemistry ; Oxidative Stress ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Wistar ; Signal Transduction ; Tumor Necrosis Factor-alpha/metabolism

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Skocz do pozycji: 2.

Tytuł:: Turmeric and vitamin C mitigate testicular atrophy induced by lead diacetate via regulation of GRP-78/17β-HSD pathways in rat's model.
Autorzy:: Fadda LM; Department of Pharmacology and Toxicology, Pharmacy College, King Saud University, Riyadh, Saudi Arabia.
Alsharidah R; Department of Pharmacology and Toxicology, Pharmacy College, King Saud University, Riyadh, Saudi Arabia.
Hasan IH; Department of Pharmacology and Toxicology, Pharmacy College, King Saud University, Riyadh, Saudi Arabia.; Pokaż więcej
Źródło:: Andrologia [Andrologia] 2021 Sep; Vol. 53 (8), pp. e14120. Date of Electronic Publication: 2021 May 24.
Typ publikacji:: Journal Article
MeSH Terms:: Curcuma*
Testis*/pathology
Animals ; Ascorbic Acid/pharmacology ; Atrophy ; Male ; Organometallic Compounds ; Oxidative Stress ; Rats ; Testosterone/metabolism

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Skocz do pozycji: 3.

Tytuł:: Chitosan nanoparticles as a promising candidate for liver injury induced by 2-nitropropane: Implications of P53, iNOS, VEGF, PCNA, and CD68 pathways.
Autorzy:: Shaheen S; Anatomy Department and Stem Cell Unit, College of Medicine, King Saud University, Riyadh, KSA.
Arafah MM; Pathology Department, College of Medicine, King Saud University, Riyadh, KSA.
Alshanwani AR; Physiology Department, College of Medicine, King Saud University, KSA.
Fadda LM; Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh, KSA.
Alhusaini AM; Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh, KSA.
Ali HM; Genetics and Cytology Department, National Research Centre, Cairo, Egypt.; Common First Year Deanship, King Saud University, Riyadh, KSA.
Hasan IH; Pharmacology and Toxicology Department, Faculty of Pharmacy, King Saud University, Riyadh, KSA.
Hagar H; Physiology Department, College of Medicine, King Saud University, KSA.; Pharmacology and Toxicology Department, College of Pharmacy, Zagazig University, Zagazig, Egypt.
Alharbi FM; Biochemistry Department, College of Science, King Saud University, Riyadh, KSA.
AlHarthii A; Physiology Department, College of Medicine, King Saud University, KSA.; Pokaż więcej
Źródło:: Science progress [Sci Prog] 2021 Apr-Jun; Vol. 104 (2), pp. 368504211011839.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Chitosan*/metabolism
Chitosan*/pharmacology
Chitosan*/therapeutic use
Nanoparticles*/therapeutic use
Nanoparticles*/toxicity
Animals ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; Liver ; Nitroparaffins ; Proliferating Cell Nuclear Antigen/genetics ; Proliferating Cell Nuclear Antigen/metabolism ; Propane/analogs & derivatives ; Rats ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism

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Skocz do pozycji: 4.

Tytuł:: Cross Talk Between TGF-β and JAK Expressions and Nepherotoxicity Induced by Tetrachloromethane: Role of Phytotherapy.
Autorzy:: Fadda LM; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Alhusaini AM; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Ali HM; Common First Year, King Saud University, Riyadh, Saudi Arabia.; Department of Genetics and Cytology, National Research Centre, Dokki, Egypt.
Hasan IH; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Badr AM; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.; Department of Pharmacology and Toxicology, College of Pharmacy, AIN Shams University, Cairo, Egypt.
Zakaria EA; Pharmaceutics Department, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.; Pokaż więcej
Źródło:: Dose-response : a publication of International Hormesis Society [Dose Response] 2019 Aug 29; Vol. 17 (3), pp. 1559325819871755. Date of Electronic Publication: 2019 Aug 29 (Print Publication: 2019).
Typ publikacji:: Journal Article

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Skocz do pozycji: 5.

Tytuł:: Quercetin and Idebenone Ameliorate Oxidative Stress, Inflammation, DNA damage, and Apoptosis Induced by Titanium Dioxide Nanoparticles in Rat Liver.
Autorzy:: Fadda LM; Faculty of Pharmacy, Pharmacology Department, King Saud University, Saudi Arabia.
Hagar H; Medical College and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
Mohamed AM; Faculty of Science, Applied Biochemistry Department, Jeddah University, Jeddah, Saudi Arabia.; Drug Industry Division, Therapeutic Chemistry Department, National Research Center, Cairo, Egypt.
Ali HM; Common First Year Deanship, King Saud University, Riyadh, Saudi Arabia.; Pokaż więcej
Źródło:: Dose-response : a publication of International Hormesis Society [Dose Response] 2018 Dec 09; Vol. 16 (4), pp. 1559325818812188. Date of Electronic Publication: 2018 Dec 09 (Print Publication: 2018).
Typ publikacji:: Journal Article

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Skocz do pozycji: 6.

Tytuł:: Role of N-Acetylcysteine and Coenzyme Q10 in the Amelioration of Myocardial Energy Expenditure and Oxidative Stress, Induced by Carbon Tetrachloride Intoxication in Rats.
Autorzy:: Elbaky NAA; Department of Pharmacology, King Saud University, Riyadh, Saudi Arabia.; Department of Pharmacology, Al-Azhar University, Cairo, Egypt.
El-Orabi NF; Department of Pharmacology, King Saud University, Riyadh, Saudi Arabia.; Department of Pharmacology and Toxicology, Suez Canal University, Ismailia, Egypt.
Fadda LM; Department of Pharmacology, King Saud University, Riyadh, Saudi Arabia.
Abd-Elkader OH; Department of Zoology, King Saud University, Riyadh, Saudi Arabia.; Electron Microscope and Thin Films Department, National Research Center, Cairo, Egypt.
Ali HM; Department of Genetics and Cytology, National Research Center, Cairo, Egypt.; King Saud University, Riyadh, Saudi Arabia.; Pokaż więcej
Źródło:: Dose-response : a publication of International Hormesis Society [Dose Response] 2018 Aug 09; Vol. 16 (3), pp. 1559325818790158. Date of Electronic Publication: 2018 Aug 09 (Print Publication: 2018).
Typ publikacji:: Journal Article

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Skocz do pozycji: 7.

Tytuł:: Downregulation of flt-1 and HIF-1α Gene Expression by Some Antioxidants in Rats Under Sodium Nitrite-Induced Hypoxic Stress.
Autorzy:: Fadda LM; Pharmacology Department, Faculty of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Attia HA; Pharmacology Department, Faculty of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.; Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Al-Rasheed NM; Pharmacology Department, Faculty of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Ali HM; Common First Year Deanship, King Saud University, Riyadh, Kingdom of Saudi Arabia.; Department of Genetics and Cytology, National Research Centre, Dokki, Egypt.
Al-Rasheed NM; Pharmacology Department, Faculty of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia.; Pokaż więcej
Źródło:: Dose-response : a publication of International Hormesis Society [Dose Response] 2018 May 27; Vol. 16 (2), pp. 1559325818776204. Date of Electronic Publication: 2018 May 27 (Print Publication: 2018).
Typ publikacji:: Journal Article

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Skocz do pozycji: 8.

Tytuł:: Role of Different Natural Antioxidants in the Modulation of mRNA-expression of Apoptotic Molecules in the Livers of Carbon Tetrachloride-Intoxicated Rats.
Autorzy:: Al-Rasheed NM; a Pharmacology Department, Faculty of Pharmacy , King Saud University , Riyadh , Kingdom of Saudi Arabia.
El-Orabi NF; a Pharmacology Department, Faculty of Pharmacy , King Saud University , Riyadh , Kingdom of Saudi Arabia.; b Department of Pharmacology and Toxicology, Faculty of Pharmacy , Suez Canal University , Ismailia , Egypt.
Fadda LM; a Pharmacology Department, Faculty of Pharmacy , King Saud University , Riyadh , Kingdom of Saudi Arabia.
Ali HM; c Department of Genetics and Cytology , National Research Center , Dokki , Egypt.; d Preparatory Year Deanship , King Saud University , Riyadh , Kingdom of Saudi Arabia.
Al-Rasheed NM; a Pharmacology Department, Faculty of Pharmacy , King Saud University , Riyadh , Kingdom of Saudi Arabia.
Bassiouni Y; a Pharmacology Department, Faculty of Pharmacy , King Saud University , Riyadh , Kingdom of Saudi Arabia.
Aldbass AM; e Biochemistry Department, Faculty of Science , King Saud University , Riyadh , Kingdom of Saudi Arabia.; Pokaż więcej
Źródło:: Animal biotechnology [Anim Biotechnol] 2017 Oct 02; Vol. 28 (4), pp. 253-259. Date of Electronic Publication: 2017 Jan 19.
Typ publikacji:: Journal Article
MeSH Terms:: Antioxidants/*pharmacology
Apoptosis/*drug effects
Apoptosis Regulatory Proteins/*metabolism
Carbon Tetrachloride/*toxicity
Gene Expression Regulation/*drug effects
Liver/*drug effects
Alanine Transaminase/blood ; Animals ; Apoptosis Regulatory Proteins/genetics ; Curcumin/pharmacology ; Liver/metabolism ; Male ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Rats ; Real-Time Polymerase Chain Reaction ; Silymarin/pharmacology ; Smad3 Protein/genetics ; Smad3 Protein/metabolism ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism ; Vitamin E/pharmacology

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Skocz do pozycji: 9.

Tytuł:: Alleviation of bone markers in rats induced nano-zinc oxide by qurecetin and α-lipolic acid.
Autorzy:: Abdelkarem HM; a Nutrition Department , National Research Center , Dokki , Cairo , Egypt.
Fadda LM; b Pharmaceutical Department, Faculty of Pharmacy , King Saud University , Riyadh , Saudi Arabia.
Kaml OR; c Biochemistry Department , National Organization for Drug Control and Research (NODCAR) , Giza , Egypt.; Pokaż więcej
Źródło:: Toxicology mechanisms and methods [Toxicol Mech Methods] 2016 Nov; Vol. 26 (9), pp. 692-699. Date of Electronic Publication: 2016 Oct 27.
Typ publikacji:: Journal Article
MeSH Terms:: Antioxidants/*pharmacology
Bone Remodeling/*drug effects
Nanoparticles/*toxicity
Quercetin/*pharmacology
Thioctic Acid/*pharmacology
Zinc Oxide/*toxicity
Animals ; Antioxidants/administration & dosage ; Biomarkers/analysis ; Biomarkers/blood ; Bone and Bones/drug effects ; Bone and Bones/metabolism ; Bone and Bones/pathology ; Cytokines/blood ; DNA Damage ; Immunoglobulin G/blood ; Male ; Nanoparticles/chemistry ; Nitric Oxide/blood ; Quercetin/administration & dosage ; Rats, Wistar ; Thioctic Acid/administration & dosage ; Zinc Oxide/chemistry

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Skocz do pozycji: 10.

Tytuł:: New mechanism in the modulation of carbon tetrachloride hepatotoxicity in rats using different natural antioxidants.
Autorzy:: Al-Rasheed NM; a Department of Pharmacology , Faculty of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia .
Fadda LM; a Department of Pharmacology , Faculty of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia .
Ali HM; b Depatment of Genetics and Cytology , National Research Center , Dokki , Egypt .; c Preparatory Year Deanship, King Saud University , Riyadh , Kingdon of Saudi Arabia .
Abdel Baky NA; a Department of Pharmacology , Faculty of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia .; d Department of Pharmacology , Faculty of Pharmacy (Girls), Al-Azhar University , Cairo , Egypt , and.
El-Orabi NF; a Department of Pharmacology , Faculty of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia .; e Department of Pharmacology and Toxicology Faculty of Pharmacy , Suez Canal University , Ismailia , Egypt.
Al-Rasheed NM; a Department of Pharmacology , Faculty of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia .
Yacoub HI; a Department of Pharmacology , Faculty of Pharmacy, King Saud University , Riyadh , Kingdom of Saudi Arabia .; Pokaż więcej
Źródło:: Toxicology mechanisms and methods [Toxicol Mech Methods] 2016 May; Vol. 26 (4), pp. 243-50. Date of Electronic Publication: 2016 Apr 04.
Typ publikacji:: Journal Article
MeSH Terms:: Antioxidants/*therapeutic use
Chemical and Drug Induced Liver Injury/*drug therapy
Curcumin/*therapeutic use
Liver Cirrhosis, Experimental/*prevention & control
Silymarin/*therapeutic use
Vitamin E/*therapeutic use
Animals ; Antioxidants/administration & dosage ; Carbon Tetrachloride/toxicity ; Chemical and Drug Induced Liver Injury/blood ; Chemical and Drug Induced Liver Injury/complications ; Chemical and Drug Induced Liver Injury/metabolism ; Curcumin/administration & dosage ; Drug Therapy, Combination ; Liver/drug effects ; Liver/enzymology ; Liver/metabolism ; Liver Cirrhosis, Experimental/blood ; Liver Cirrhosis, Experimental/etiology ; Liver Cirrhosis, Experimental/metabolism ; Liver Function Tests ; Male ; Rats, Sprague-Dawley ; Silymarin/administration & dosage ; Vitamin E/administration & dosage

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Skocz do pozycji: 11.

Tytuł:: Effect of aliskiren and carvedilol on expression of Ca(2+)/calmodulin-dependent protein kinase II δ-subunit isoforms in cardiac hypertrophy rat model.
Autorzy:: Bin-Dayel AF; a Department of Pharmacology , Faculty of Pharmacy, King Saud University , Riyadh , Saudi Arabia .
Abdel Baky NA; a Department of Pharmacology , Faculty of Pharmacy, King Saud University , Riyadh , Saudi Arabia .; b Pharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University , Cairo , Egypt .
Fadda LM; a Department of Pharmacology , Faculty of Pharmacy, King Saud University , Riyadh , Saudi Arabia .
Mohammad RA; c Anatomy Department, Faculty of Medicine, King Saud University , Riyadh , Saudi Arabia , and.
Al-Mohanna F; d Department of Cell Biology , King Faisal Specialist Hospital & Research Centre , Riyadh , Saudi Arabia.; Pokaż więcej
Źródło:: Toxicology mechanisms and methods [Toxicol Mech Methods] 2016 Feb; Vol. 26 (2), pp. 122-31. Date of Electronic Publication: 2016 Mar 16.
Typ publikacji:: Journal Article
MeSH Terms:: Amides/*therapeutic use
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*antagonists & inhibitors
Carbazoles/*therapeutic use
Cardiomegaly/*drug therapy
Fumarates/*therapeutic use
Propanolamines/*therapeutic use
Renin-Angiotensin System/*drug effects
Amides/administration & dosage ; Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Carbazoles/administration & dosage ; Cardiomegaly/chemically induced ; Cardiomegaly/enzymology ; Carvedilol ; Creatine Kinase, MB Form/blood ; Disease Models, Animal ; Drug Therapy, Combination ; Fumarates/administration & dosage ; Heart/drug effects ; Isoproterenol/toxicity ; Male ; Myocardium/metabolism ; Organ Size/drug effects ; Propanolamines/administration & dosage ; Protein Isoforms ; Rats, Wistar ; Real-Time Polymerase Chain Reaction ; Renin/blood ; Troponin T/blood

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