Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders.
Autorzy:
Bräuer S; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany. Rossi M; IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy. Sajapin J; Department of Food Chemistry, TU Dresden, Dresden, Germany. Henle T; Department of Food Chemistry, TU Dresden, Dresden, Germany. Gasser T; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. Parchi P; IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy.; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. Brockmann K; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. FalkenburgerBH; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. .; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany. .
Development and Validation of a Fall Questionnaire for Patients with Parkinson's Disease.
Autorzy:
Frank A; Department of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus Dresden Germany.; German Center for Neurodegenerative Diseases Dresden Germany. Bendig J; Department of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus Dresden Germany. Finkbeiner S; Department of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus Dresden Germany. Hähnel T; Department of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus Dresden Germany. Schnalke N; Department of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus Dresden Germany. Feige T; Department of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus Dresden Germany. Reichmann H; Department of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus Dresden Germany. FalkenburgerBH; Department of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus Dresden Germany.; German Center for Neurodegenerative Diseases Dresden Germany.
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Źródło:
Movement disorders clinical practice [Mov Disord Clin Pract] 2022 Jul 23; Vol. 9 (7), pp. 900-908. Date of Electronic Publication: 2022 Jul 23 (Print Publication: 2022).
Alpha-Synuclein-Specific Naturally Occurring Antibodies Inhibit Aggregation In Vitro and In Vivo.
Autorzy:
Braczynski AK; Department of Neurology, RWTH University Hospital, 52074 Aachen, Germany.; Institut für Physikalische Biologie, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany. Sevenich M; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, 52428 Jülich, Germany.; Priavoid GmbH, 40225 Düsseldorf, Germany. Gering I; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, 52428 Jülich, Germany. Kupreichyk T; Institut für Physikalische Biologie, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, 52428 Jülich, Germany. Agerschou ED; Institut für Physikalische Biologie, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany. Kronimus Y; Department of Geriatric Medicine, University Hospital Essen, University Duisburg-Essen, 47057 Duisburg, Germany. Habib P; Department of Neurology, RWTH University Hospital, 52074 Aachen, Germany.; Institute of Biochemistry and Molecular Immunology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany. Stoldt M; Institut für Physikalische Biologie, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, 52428 Jülich, Germany. Willbold D; Institut für Physikalische Biologie, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, 52428 Jülich, Germany. Schulz JB; Department of Neurology, RWTH University Hospital, 52074 Aachen, Germany.; JARA-Institute Molecular Neuroscience and Neuroimaging, Jülich Aachen Research Alliance, FZ Jülich and RWTH University, 52428 Jülich, Germany. Bach JP; Department of Neurology, RWTH University Hospital, 52074 Aachen, Germany. FalkenburgerBH; Department of Neurology, RWTH University Hospital, 52074 Aachen, Germany.; Department of Neurology, University Hospital Carl Gustav Carus, 01307 Dresden, Germany. Hoyer W; Institut für Physikalische Biologie, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, 52428 Jülich, Germany.
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Źródło:
Biomolecules [Biomolecules] 2022 Mar 18; Vol. 12 (3). Date of Electronic Publication: 2022 Mar 18.
Feasibility of a Multimodal Telemedical Intervention for Patients with Parkinson's Disease-A Pilot Study.
Autorzy:
Bendig J; Department of Neurology, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany. Wolf AS; Department of Neurology, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany. Mark T; Department of Neurology, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany. Frank A; Department of Neurology, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), 01307 Dresden, Germany. Mathiebe J; Center for Evidence-Based Healthcare, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany. Scheibe M; Center for Evidence-Based Healthcare, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany. Müller G; Center for Evidence-Based Healthcare, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany. Stahr M; Department of Neurology, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany.; Department of Psychiatry, Sächsisches Krankenhaus Arnsdorf, 01477 Arnsdorf, Germany. Schmitt J; Center for Evidence-Based Healthcare, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany. Reichmann H; Department of Neurology, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany. Loewenbrück KF; Department of Neurology, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany. FalkenburgerBH; Department of Neurology, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), 01307 Dresden, Germany.
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Źródło:
Journal of clinical medicine [J Clin Med] 2022 Feb 18; Vol. 11 (4). Date of Electronic Publication: 2022 Feb 18.
Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not.
Autorzy:
Frank A; Department of Neurology, University Hospital Carl Gustav Carus, Dresden, Germany.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany. Bendig J; Department of Neurology, University Hospital Carl Gustav Carus, Dresden, Germany. Schniewind I; Department of Neurology, University Hospital Carl Gustav Carus, Dresden, Germany. Polanski WH; Department of Neurosurgery, University Hospital Carl Gustav Carus, Dresden, Germany. Sobottka SB; Department of Neurosurgery, University Hospital Carl Gustav Carus, Dresden, Germany. Reichmann H; Department of Neurology, University Hospital Carl Gustav Carus, Dresden, Germany. Akgün K; Department of Neurology, Center of Clinical Neuroscience, Technische Universität Dresden, Dresden, Germany. Ziemssen T; Department of Neurology, Center of Clinical Neuroscience, Technische Universität Dresden, Dresden, Germany. Klingelhoefer L; Department of Neurology, University Hospital Carl Gustav Carus, Dresden, Germany. FalkenburgerBH; Department of Neurology, University Hospital Carl Gustav Carus, Dresden, Germany. bjoern.falkenburger@uniklinikum-dresden.de.; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany. bjoern.falkenburger@uniklinikum-dresden.de.; Department of Neurology, Technische Universität Dresden, University Hospital Carl Gustav Carus, Dresden, Germany. bjoern.falkenburger@uniklinikum-dresden.de.
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Źródło:
Scientific reports [Sci Rep] 2022 Jan 27; Vol. 12 (1), pp. 1446. Date of Electronic Publication: 2022 Jan 27.
Typ publikacji:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
PIP 2 determines length and stability of primary cilia by balancing membrane turnovers.
Autorzy:
Stilling S; Department of Neurology, RWTH Aachen University, Aachen, Germany.; Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University, Baltimore, MD, USA. Kalliakoudas T; Department of Neurology, TU Dresden, Dresden, Germany. Benninghoven-Frey H; Department of Neurology, RWTH Aachen University, Aachen, Germany. Inoue T; Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University, Baltimore, MD, USA. FalkenburgerBH; Department of Neurology, RWTH Aachen University, Aachen, Germany. .; Department of Neurology, TU Dresden, Dresden, Germany. .; JARA-Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Aachen, Germany. .
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Źródło:
Communications biology [Commun Biol] 2022 Jan 25; Vol. 5 (1), pp. 93. Date of Electronic Publication: 2022 Jan 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Improved in vivo PET imaging of the adenosine A 2A receptor in the brain using [ F]FLUDA, a deuterated radiotracer with high metabolic stability.
Autorzy:
Lai TH; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany. .; Department of Research and Development, ROTOP Pharmaka Ltd., Dresden, Germany. . Toussaint M; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany. . Teodoro R; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany. Dukić-Stefanović S; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany. Gündel D; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany. Ludwig FA; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany. Wenzel B; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany. Schröder S; Department of Research and Development, ROTOP Pharmaka Ltd., Dresden, Germany. Sattler B; Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany. Moldovan RP; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany. FalkenburgerBH; Department of Neurology, Dresden University Medical Center, Dresden, Germany. Sabri O; Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany. Deuther-Conrad W; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany. Brust P; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany.
Dinter E; Department of Neurology, Technische Universität Dresden, Dresden, Germany.; Deutsches Zentrum für Neurodegenerative Erkrankungen, Dresden, Germany. Saridaki T; Department of Neurology, RWTH University Aachen, Aachen, Germany. Diederichs L; Department of Neurology, RWTH University Aachen, Aachen, Germany. Reichmann H; Department of Neurology, Technische Universität Dresden, Dresden, Germany. FalkenburgerBH; Department of Neurology, Technische Universität Dresden, Dresden, Germany. .; Deutsches Zentrum für Neurodegenerative Erkrankungen, Dresden, Germany. .; Department of Neurology, RWTH University Aachen, Aachen, Germany. .
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Źródło:
Translational neurodegeneration [Transl Neurodegener] 2020 Dec 01; Vol. 9 (1), pp. 43. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
Changes in Striatal Medium Spiny Neuron Morphology Resulting from Dopamine Depletion Are Reversible.
Autorzy:
Witzig VS; Department of Neurology, RWTH Aachen University, 52074 Aachen, Germany. Komnig D; Department of Neurology, RWTH Aachen University, 52074 Aachen, Germany. FalkenburgerBH; Department of Neurology, RWTH Aachen University, 52074 Aachen, Germany.; JARA-Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, 52074 Aachen, Germany.; Department of Neurology, Technische Universität Dresden, 01307 Dresden, Germany.; Deutsches Zentrum für Neurodegenerative Erkrankungen, 01307 Dresden, Germany.
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Cells [Cells] 2020 Nov 09; Vol. 9 (11). Date of Electronic Publication: 2020 Nov 09.
ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP Model of Parkinson Disease.
Autorzy:
Komnig D; Department of Neurology, RWTH Aachen University, Aachen, Germany. Imgrund S; Institute of Physiology, RWTH Aachen University, Aachen, Germany. Reich A; Department of Neurology, RWTH Aachen University, Aachen, Germany. Gründer S; Institute of Physiology, RWTH Aachen University, Aachen, Germany. FalkenburgerBH; Department of Neurology, RWTH Aachen University, Aachen, Germany.; JARA BRAIN Institute II, Jülich and Aachen, Germany.
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Źródło:
PloS one [PLoS One] 2016 Nov 07; Vol. 11 (11), pp. e0165235. Date of Electronic Publication: 2016 Nov 07 (Print Publication: 2016).
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